LOCUS       NZ_CP028720            20729 bp    DNA     circular CON 21-NOV-2024
DEFINITION  Enterococcus faecalis strain CVM N48037F chromosome, complete
            genome.
ACCESSION   NZ_CP028720
VERSION     NZ_CP028720.1
KEYWORDS    RefSeq.
SOURCE      Enterococcus faecalis
  ORGANISM  Enterococcus faecalis
            Bacteria; Bacillati; Bacillota; Bacilli; Lactobacillales;
            Enterococcaceae; Enterococcus.
REFERENCE   1  (bases 1 to 2997828)
  AUTHORS   Tyson,G.H., Sabo,J.L., Hoffmann,M., Hsu,C.H., Mukherjee,S.,
            Hernandez,J., Tillman,G., Wasilenko,J.L., Haro,J., Simmons,M.,
            Wilson Egbe,W., White,P.L., Dessai,U. and Mcdermott,P.F.
  TITLE     Novel linezolid resistance plasmids in Enterococcus from food
            animals in the USA
  JOURNAL   J Antimicrob Chemother 73 (12), 3254-3258 (2018)
   PUBMED   30272180
REFERENCE   2  (bases 1 to 2997828)
  AUTHORS   Tyson,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2018) CVM/OR, FDA, 8401 Muirkirk Rd, MOD2, Laurel,
            MD 20708, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 603x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004332015.1-RS_2024_11_19
            Annotation Date                   :: 11/19/2024 19:35:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,059
            CDSs (total)                      :: 2,981
            Genes (coding)                    :: 2,931
            CDSs (with protein)               :: 2,931
            Genes (RNA)                       :: 78
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 50
            CDSs (without protein)            :: 50
            Pseudo Genes (ambiguous residues) :: 0 of 50
            Pseudo Genes (frameshifted)       :: 30 of 50
            Pseudo Genes (incomplete)         :: 21 of 50
            Pseudo Genes (internal stop)      :: 15 of 50
            Pseudo Genes (multiple problems)  :: 12 of 50
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:04:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2316516
            Orig. end                         :: 2337245
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP028720.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20729
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="4"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..20729
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20729
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10729](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10729
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    3..17
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.5"
                     /tool="antismash"
     gene            164..559
                     /locus_tag="C7I32_RS11895"
     CDS             164..559
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002407764.1"
                     /locus_tag="C7I32_RS11895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_002361986.1"
                     /transl_table=11
                     /translation="MDGMFANLTLRERRLLKQAQVGATISFILLFVPILTISLLHTSDL
                     LAKWLGIVGVIMVLPLLYFAWQILKIAYKDQKDNPTPPLWVPKVYGIGLSINPYHRFGK
                     LIFILLAVLIVGIIISLLFTPASQINH"
     gene            1063..6747
                     /locus_tag="C7I32_RS11900"
     CDS             1063..6747
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002414300.1"
                     /locus_tag="C7I32_RS11900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIM-barrel domain-containing protein"
                     /protein_id="WP_238641504.1"
                     /transl_table=11
                     /translation="MGSNFKEEKMNKEYQGKKIYGKKHWLTFLLVSSSVLAFHSFVTMD
                     SQVVDAQEQTAKEDVADSATSVGAIVSIEKAEKNFVITYASGKKAQISILNDHLFRYHL
                     DPTGKFEEYPTPNDPKHVAKITAKTMADYGTQAFEQTNVTDSGNQSILENNGLKIIFEK
                     ESALMKVLDKKKNQVILEETAPLSFKNDKATQTLKQSSQENYFGGGTQNGRFTHKGTAI
                     QIVNTNNWVDGGVASPNPFYWSTAGYGVVRNTWKPGNYDFGSHDPQTTTTTHEGTDFDA
                     FYFFNDSSAGILKDYYELTGKPALMPEYGFYEAHLNAYNRDYWVKVAEGTAGAVKFEDG
                     NFYKEYQPGDLGNLNGTLESLNGEKENYQFSARAVIDRYKKNDMPLGWFLPNDGYGAGY
                     GQTDSLDGDVQNLKEFTEYAQANGVEVGLWTQSNLHPADPKNPKKGERDIAKEVSVAGV
                     KALKTDVAWVGYGYSFGLNGVEDAANVFVKETDGAVRPMIVSLDGWAGTQRHAGIWTGD
                     QTGGQWEYIRFHIPTYIGTSLSGQPNVGSDMDGIFGGKNKEVNIRDFQWKTFTPVQLNM
                     DGWGSNPKTPFAFDQEATDLNRAYLKLKSMMMPYNYSIAKESVDGLPMVRAMALEFPNE
                     GTAYTKDSQYQYMWGPNLLVAPIYNGNQDEAGNSIRDGIYLPDEKQVWVDLFTGEKYQG
                     GRVLNGVKTPLWKVPVFVKDGSIIPMTNPNNNPKEIQRDQRSFLIYPNGTTSFNMYEDD
                     GISTSYEAGQSATTKINSQGPKSNEKGDLTVTIEPTKGSYSGFVDERSTTLDLLASEAP
                     ESVTAMVGGTEVTLKQAANKEEFLAGTNLYYFDKEFQVNQYLSEASGEKLNQSALSVKL
                     AKQSVTAKDVQITVKGFINKGTVDGGNTTVDDQLTIPANVAINEEKTTPSSLTLQWDQV
                     TEATSYEVERDGTVFGNIQTNTATFDGFSFLSEHTFRVRAVGKNGVSEWSEPIKGKTQD
                     DPYKETINQVKATSNLPEQPGAELKKLTDKDLSTGWHTNWSTGIANPSDGNFLSLKFDL
                     GAEYQMDKIEYLPRDNAGNGNILQLQYRTSKDGANWTEFSEPINWKQDALTKTIETKEQ
                     AYRFVEMKVLKSVGNFGSGREMLFYKQPGTEGILHGDITNDGTIDENDAMSYRNYTGLE
                     SVDSDFNGYVEKGDLNKNGVIDAYDISYVLRQLDGGIEIPDVEEIAGGLSLAVVNENGK
                     DTYLPGDTLTFTLKGQDLKNINALSTKMSFDSSKFELVGQPATTNNTKQMENYSKYRKH
                     SNDVENLYLVLSNQGNKQLLNGSMDLVTFKVKVKETTRVKRATTVEQPLQFDMSQGLLV
                     GQGFQQATLSDFSVTVKPTELVDKELLQALITLNQARVEKEYTPETWAIFKPVLDEAVA
                     VLANEQATQTDVSAAVENLEKAASQLEKMPDVANKADLEKAIQEGLAKKPSDGQEFTEE
                     TKKVLEDSLAAAQKVFAQEKVTQEEIDQATKTLREAIAQLKEQPVAVDKETLKEKIAQA
                     RGRKPEEGYQFTKETEKQLQEAIQAAEAIVAKETATKEEVSEALNALETAMAQLKEVPL
                     VNKDQLQEVVKRAQQVTPSEGHQFTASSLQDLQKALLAAKNTLENPAANQKMIDEAVAE
                     LTSAIDGLQEEALVTDKKALEAMIAKAKAIKPSAGKEFTSESKARLTEAIDQAEGILAD
                     KNARQEQIDTAEKNVKTALDSLEEQVLQADKTKLRELLQKAETLKPKAGKQFTKASQEA
                     LAEAIKQAKALVEDPSATQEAVDKCLSILAQAIEAMAEEPISSNSTGNNRNHGTVSGTG
                     SVTSPGKGTAAGGTTTKTTTSGTLPKANEVVSPIWSISGFLLIVSIGLGKLFFKNKKDK
                     ISVSLTYKAHLYKNSVQMRK"
     gene            6771..8762
                     /locus_tag="C7I32_RS11905"
     CDS             6771..8762
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002401391.1"
                     /locus_tag="C7I32_RS11905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidase domain-containing protein"
                     /protein_id="WP_033626455.1"
                     /transl_table=11
                     /translation="MKRKKIKNQLLVLTSILVLLSLEVAPVVTLAAELPSSSLQTALSS
                     ETTITSEEKVIETTETTETTETTVATSTTSTSSSSSESNSSTDTTTESTSHSTTETTTT
                     NTSSETKKEPTEPTVSSEITQPIEQSQPPQVQPPQVPVTKQEPEEPIQVPEATNNVVEE
                     NQAVSLNPSLKVDEIASSNLKGYELPLLSSFGEKKRAVVVAEALRHIGKTKKEFNLTEQ
                     ALTSSFLAQKIYQQLFKIDIGSTPQEQMTFGKVRSIEEAEPGDLIFWQTAEGKTLQNGV
                     YLGQGKYLIAAAEADSKEKPEVIAQLENIYTAKQQPDSKEEKRLVVTNPFKEFILTEYG
                     KEVLATYGASFEMQKSEQATAFIKKIGETARELGEKYDVFASVMIAQAILESGSGESQL
                     AKEPYYNLFGVKGSFQGNSVSFSTKEADQRGQLYTISAGFRDYGGYNDSLQDYVQLLRQ
                     GIDGNQDFYKPAWRSEAKNYLQATRFLTGKYATDKQYDNKLNSLIAVYNLTQFDLPKTA
                     DGLIIQSKNELSEAEQQQMHFPVYDGINYNRSGSYPVGQCTWYVYNRFKQLGTSVDEFM
                     GNGSDWGRKGRALGYQVSSLPKAGRAISFQPGVAGADNQYGHVAFVEAVTSDGIIISES
                     NVINDQTISYRVLPNAIAYSSGVTYIGA"
     misc_feature    complement(9054..9069)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     gene            9181..9912
                     /gene="fsrA"
                     /locus_tag="C7I32_RS11910"
     CDS             9181..9912
                     /codon_start=1
                     /gene="fsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011109506.1"
                     /locus_tag="C7I32_RS11910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator FsrA"
                     /protein_id="WP_078126945.1"
                     /transl_table=11
                     /translation="MAIYILEDQIIQAKALEALLTNILHSRNIYNETIHLFSRSDELLQ
                     VAHQDAQLNIFFLDIQMNNHIQAGFEVAKEIRKTDSESLIVFISTHTELVLTSYKYMVS
                     ALQFIQKNVDFLDFQKEVETCVDAYIQQKENIKTKSEYIIINLKASSIKMDINDIYFFQ
                     TEYDHRVSMVGKNFKREFYGTLSKIEQLHPDLIRVHQSIIINKKYASKLNYKTHLLTMR
                     DGTEVPVSRRYYTQVKALFLT"
     gene            10001..10729
                     /locus_tag="C7I32_RS11915"
     CDS             10001..10729
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016634271.1"
                     /locus_tag="C7I32_RS11915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_016626960.1"
                     /sec_met_domain="AgrB (E-value: 1.4e-31, bitscore: 106.6,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIDWILKNIMDMDQEDQSGKTQWTKYYLTVYFSGLFNFLMILIL
                     SVLFGTLSETFIVYVVLIFLRPVAGGWHAKTKWLCRLESIVIYVAIPFVLKNSSVSLPF
                     IYKILLMCLLVVLFYWYAPQGTAIEPVQPSDLNVLKKQSLIRVCLLILCSLFVKEKIAS
                     VILYGLVIQGLMILPVTKNLIEGSVFMKFGKKIIKNVIEKRVAKVSDGVGTKPRLNQNS
                     PNIFGQWMGQTEKPKKNIEK"
     gene            10726..12069
                     /gene="fsrC"
                     /locus_tag="C7I32_RS11920"
     CDS             10726..12069
                     /codon_start=1
                     /gene="fsrC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002402207.1"
                     /locus_tag="C7I32_RS11920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase FsrC"
                     /protein_id="WP_002392317.1"
                     /transl_table=11
                     /translation="MILSLLATNVLLVSSFIVFVFLRVTLIKIECKIPLLSLLIVINLC
                     SFAALMLGYSWLIYALTVVIFTGFLLIHKKRFSIFKAIFLSVFTLLMVSFINYTEQTIL
                     SVFFQQIYQNKLLWIASNVLLLLINIWIALKIPNSVFLRLNRVLENSRIFFGCLLLLLI
                     LLLLFVFLISPEISPDFMRGFVTVNSSKLELLISVGLFLILIGLVIEAYLEEQRINTQL
                     LNNLTIYTEKIESINEELAMFRHDYKNLLYSLQIAISYEDILEIKRIYEETIAPTKKII
                     DNEEFELMKLNRLKNMELKALISMKINTAKQAKLKVIVDVPEVFILDTSIDLVVVIRLL
                     AILLDNAIENSAKSELKMFAISIFNKNETQEFVITNSVQAEFDFRVMKKTKFSSKSNPE
                     EHGWGLLYVKEIVDFSDQFDLQTSFNEGSVTQHLIIEKNHNSKKVVNE"
     gene            12304..13836
                     /gene="gelE"
                     /locus_tag="C7I32_RS11925"
     CDS             12304..13836
                     /EC_number="3.4.24.30"
                     /codon_start=1
                     /gene="gelE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002369251.1"
                     /locus_tag="C7I32_RS11925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M4 family metallopeptidase coccolysin"
                     /protein_id="WP_002357227.1"
                     /transl_table=11
                     /translation="MMKGNKILYILGTGIFVGSSCLFSSLFVAAEEQVYSESEVSTVLS
                     KLEKEAISEAAAEQYTVVDRKEDAWGMKHLKLEKQTEGVTVDSDNVIIHLDKNGAVTSV
                     TGNPVDQVVKIQSVDAIGEEGVKKIIASDNPENKDLVFLAIDKRVNNEGQLFYKVRVTS
                     SPTGDPVSLVYKVNATDGTIMEKQDLTEHVGSEVTLKNSFQVTFNVPVEKSNTGIALHG
                     TDNTGVYHAVVDGKNNYSIIQAPSLATLNQNAVDAYTHGKFVKTYYEDHFQRHSIDDRG
                     MPILSVVDEQHPDAYDNAFWDGKAMRYGETSTPTGKTYASSLDVVGHEMTHGVTEHTAG
                     LEYLGQSGALNESYSDLMGYIISGASNPEIGADTQSVDRKTGIRNLQTPSKHGQPETMA
                     QYDDRARYKGTPYYDQGGVHYNSGIINRIGYTIIQNLGIEKAQTIFYSSLVNYLTPKAQ
                     FSDARDAMLAAAKVQYGDEAASVVSAAFNSAGIGAKEDIQVNQPSESVLVNE"
     gene            13885..14739
                     /gene="sprE"
                     /locus_tag="C7I32_RS11930"
     CDS             13885..14739
                     /codon_start=1
                     /gene="sprE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002364098.1"
                     /locus_tag="C7I32_RS11930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine proteinase SprE"
                     /protein_id="WP_131501901.1"
                     /transl_table=11
                     /translation="MKKFSIRKISAGFLFLILVTLIAGFSLSANAEEYIVPAESHSRQK
                     RSLLDPEDRRQEVADTTEAPFASIGRIISPASKPGYISLGTGFVVGTNTIVTNNHVAES
                     FKNAKVLNSNAKDDAWFYPGRDGSATPFGKFKVIDVAFSPNADIAVVTVSKQNDRPDGP
                     ELGEILTPFVLKKFESSDTHVTISGYPGEKNHTQWSHENDLFTSNFTDLENPLLFYDID
                     TTGGQSGSPIYNAQFEVVGVHSNGGIKQTGNHGQRLNEVNYNFIVNRVNEEENKRLSAV
                     PAA"
     gene            complement(14887..15717)
                     /locus_tag="C7I32_RS11935"
     CDS             complement(14887..15717)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002397393.1"
                     /locus_tag="C7I32_RS11935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_002357232.1"
                     /transl_table=11
                     /translation="MKINYLGTGAAERIPGIFCNCKLCKYAREKKGREIRTQTQLIIDD
                     VLLIDFPGDSYLHLLQYDLCFADFDSLLISHWHSDHFYGEDLAYRMSGYALDIPNRLTV
                     YGNEAVKTFYQRAFDLEGRQDDTRLHYQVIQPYKCFTIANYTIYPLPAQHGNFSEDCFI
                     FVIDDGKDAFLSTHDTGYFTSEMFEYLEKSHLLLSIVSLDCTSQTNETGNSHMNWEENL
                     KLITELKERKLVTDKTIYVANHFSHNGGLSYAEMAALSQKHEIITSYDGLEILT"
     gene            16109..16963
                     /locus_tag="C7I32_RS11940"
     CDS             16109..16963
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010821679.1"
                     /locus_tag="C7I32_RS11940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_002357233.1"
                     /transl_table=11
                     /translation="MTIEKLEYFYTIAKYNSISKAASELHVSKSTLSASLKDLESELGH
                     LLFDRNGNSLTLNSYGDKIVQSVYIILNEAKKMKLNLHEMIENPVMRLGFGNTSLMYKV
                     TENEDQLNRFWECYHGSSFELLNKLENHELDFVITSADVNSPVLKKEQLIELKMYLCVS
                     REIKQEIEEEGFTCLTNYPFLFLPHHLDHLEATKSVLEMLQLTSPLVCCYDTLMLTRLI
                     EKSKGVYAVISLRKEQLQEIDSKLFFLPIERKQKFYLYRNVSSSVFVQPGQIKATLQKL
                     LET"
     gene            17384..18733
                     /locus_tag="C7I32_RS11945"
                     /pseudo=""
     CDS             17384..18733
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002393341.1"
                     /locus_tag="C7I32_RS11945"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSLFVVTMDVTVVNVALPSIQSDFHTNLSTLQWVTDGYTLMVASL
                     LLLSGSTADRIGRKRVLQLGLACFGLASFLCGISQTPGQLIAFRMLQGIGGSMLNPVAM
                     SIITQVFTEKLERAKAIGLWGSVTGISLGMGPIIGGLIVSYFSWRYVFFVNVPIIAAAI
                     ILTQ"
     misc_feature    complement(20138..20152)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(20415..20428)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.02"
                     /tool="antismash"
     misc_feature    complement(20608..20623)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: strong, score: 28.99"
                     /tool="antismash"
ORIGIN
        1 aaggaaaagt tgttcctgtt tgtcaaacac gtcaaccaga agaaattaat gctatttttg
       61 aagaaatgga acaaggaaaa attcgcgggc gcatggtcat tgattttcgc agttaattta
      121 gttttttagt gattcgttga tttaatctga ataccatgaa aggatggatg gaatgtttgc
      181 gaatcttact ctccgtgaga gacgactgct taaacaagca caagtgggag ccacaattag
      241 ctttattctt ttgtttgtac caattctgac aatcagtctt ttgcatacta gtgacttatt
      301 agcaaaatgg ctaggtatag ttggggtaat tatggtttta ccattgttgt attttgcgtg
      361 gcagatttta aagatagcct ataaagatca aaaagataat ccaacgcctc ctttgtgggt
      421 tccgaaagtt tatgggattg ggctttcgat caatccctat caccggtttg gaaagttaat
      481 ttttatattg ctagcggtac tgatagttgg catcatcatt agtttgcttt tcacaccagc
      541 aagtcaaatc aatcactaaa aaacgagtaa tcaacaccct cttgccgagc aggagggtgt
      601 tgattatttt taaatagact aaatttgagt aacaggtatt agatttttaa aaaagtcttt
      661 ctttttctga tgtagatatt ttcgcaataa aatcatcatt ataagtgaat taacaggttt
      721 atcaagggtt aatacttgtt aatggtggct gctataatta accgttgaca aacacaaaaa
      781 aaccatcata cgataattat gttattaaaa aagtgaaaaa ttggtagtca acaaatgaaa
      841 acgcattcat cgggaaattg tgattctgta ctaaaatttt tatataagat gaaaatagat
      901 tgttttcatt taataattta ttgaaaggat gtgtttatgg aggggttact gaaactgact
      961 ttctaacagt ctcagtaaac taagaaaatc gttatgactt ttcatctgga taaaactttg
     1021 ttgggttttg gattttgtga gtaattgtgt cggaactatt ctatggggag caattttaag
     1081 gaggaaaaaa tgaacaaaga gtatcagggt aaaaaaattt acggtaaaaa gcactggttg
     1141 acatttttat tagtgagttc gtctgtattg gcgttccatt cgtttgttac gatggattct
     1201 caagtggttg atgcgcaaga gcaaacagca aaagaagacg tagctgattc agcaacgtca
     1261 gtcggagcaa ttgtgtcgat tgaaaaagcg gagaaaaact ttgtcattac gtatgcttct
     1321 ggaaaaaaag cacaaattag tattttaaac gaccatcttt ttcgctatca tctagatcca
     1381 actggtaaat ttgaagaata tccaacgcca aatgatccaa agcatgttgc gaaaattacg
     1441 gctaaaacaa tggccgacta tggcacacaa gcctttgagc aaacgaacgt cacagattca
     1501 ggaaaccaat ctattctaga aaataatggt ttaaaaatta tattcgaaaa agaaagcgct
     1561 ttaatgaagg ttctagacaa gaaaaagaat caagttattt tagaagaaac cgctccgcta
     1621 tcctttaaaa atgataaagc tacacaaacg ttaaaacaaa gtagtcaaga aaattatttt
     1681 ggcggaggaa ctcaaaatgg tcgatttacg cataaaggaa cagctatcca gattgtcaat
     1741 acgaacaatt gggtagatgg cggagtagca tcgcctaacc cattttattg gtcaactgca
     1801 gggtatggcg ttgttcgaaa tacatggaaa cctggcaact atgattttgg aagtcatgat
     1861 ccacaaacaa ccacaacaac gcacgaagga acagattttg atgcttttta tttctttaat
     1921 gattcctcag caggtatttt aaaagattac tatgaattaa ccgggaaacc agctttgatg
     1981 ccagaatacg ggttctatga agcacattta aacgcgtata atcgggacta ttgggtgaaa
     2041 gtagcagaag gaaccgcggg agcagttaag tttgaagatg gtaattttta caaagaatac
     2101 caaccaggcg atctaggaaa cttaaatggc acgctagaat ctttaaatgg agaaaaagag
     2161 aattatcaat tttctgcacg cgcagttatt gatcgatata agaaaaacga tatgccgtta
     2221 gggtggttct tgccaaatga cggctacggt gctggctatg gccaaacaga ttcattggac
     2281 ggcgatgtac aaaacttaaa agaatttaca gagtatgctc aagccaatgg tgttgaagtg
     2341 gggctgtgga ctcaatctaa tctccatcca gcggatccta aaaatcctaa aaaaggagaa
     2401 cgggatattg cgaaagaagt tagtgtcgct ggtgttaaag ctctcaaaac tgacgtggcg
     2461 tgggtcgggt atgggtattc ctttggctta aatggtgtag aagatgccgc gaatgttttt
     2521 gtaaaagaaa cagacggcgc agttcgtccg atgattgttt cattagatgg ttgggccgga
     2581 acccaacggc acgctggtat ttggacaggc gatcaaacgg gtggtcaatg ggaatatatt
     2641 cgcttccata tcccaacata tatcgggact tcgttgtctg gacaaccaaa tgtcggttca
     2701 gatatggatg gaatttttgg tggaaaaaat aaagaggtca acatacgtga tttccaatgg
     2761 aaaactttta caccagtgca gctaaatatg gacggctggg gctccaatcc aaaaacgcca
     2821 tttgcttttg atcaagaagc cacagatttg aaccgagcgt atctaaaatt aaaatcaatg
     2881 atgatgcctt ataactacag tattgccaag gaatcagttg atggactacc aatggtacgg
     2941 gccatggctt tagaatttcc taatgaagga acagcatata caaaagattc tcaataccaa
     3001 tatatgtggg gacccaattt actcgttgcc ccaatttata atggcaatca agatgaggca
     3061 ggaaattcaa tccgtgatgg aatctactta ccagatgaaa aacaagtctg ggttgactta
     3121 tttacaggcg aaaaatatca aggtggccgt gtcttaaatg gagtaaaaac accgctgtgg
     3181 aaggtgcccg ttttcgtcaa agatggcagt attatcccaa tgacgaatcc aaacaacaat
     3241 ccaaaggaaa tccaacgaga tcaacgatct ttcttgattt atccaaatgg caccacttct
     3301 tttaatatgt atgaagatga cggaatttca actagttatg aagctgggca atcagctacg
     3361 actaaaataa atagtcaagg ccctaaatca aacgaaaaag gggatctgac cgttactatc
     3421 gaaccgacaa aaggaagtta tagtggcttt gttgatgaac gaagcaccac gcttgatttg
     3481 ctagcttcag aagcgcccga aagcgtaaca gcaatggtgg ggggaacaga agtaaccttg
     3541 aaacaagcag ctaataaaga agaattttta gctggtacaa atctatatta ttttgataaa
     3601 gaattccaag tgaatcagta tctttctgaa gcttcaggag aaaaactgaa ccaatcagcg
     3661 ttatcagtaa aactagcgaa acaatctgtg accgccaaag atgttcaaat aactgtcaaa
     3721 ggtttcatta ataaaggaac ggttgacgga ggaaatacaa cggtcgatga ccagttaact
     3781 attccggcaa atgtcgcaat caatgaagaa aaaacaacgc catcttcttt gactcttcaa
     3841 tgggatcaag taactgaggc aacaagctat gaagtagagc gtgacggaac tgttttcgga
     3901 aatattcaaa cgaatacagc aacatttgat ggattttcct tcctaagcga acatactttt
     3961 cgagttcgag ctgttggaaa aaacggggtc tctgaatgga gtgaaccgat taaaggaaaa
     4021 acacaagatg atccctataa agaaacaatt aatcaagtca aagcaacaag taatttacca
     4081 gaacaaccag gcgcagaatt gaagaaatta acagataaag atttgagtac aggttggcat
     4141 acgaactggt caaccggcat cgctaatcca agtgatggaa atttcttgtc tttaaaattt
     4201 gatcttggtg cggagtatca aatggataaa attgaatact tgccaagaga caatgccggc
     4261 aacggaaata ttttgcaact ccagtatcgg acgtcgaaag atggagctaa ttggacagag
     4321 ttttcagaac ctattaactg gaagcaagat gctttgacaa aaaccattga aacgaaggag
     4381 caagcgtatc gttttgttga aatgaaggta ttaaaatcgg tgggtaattt tggctctggt
     4441 cgtgagatgc tcttttacaa acaaccagga acagaaggaa tcttacatgg agacattact
     4501 aatgatggaa cgattgatga aaatgatgca atgagttatc gaaactatac aggcttagaa
     4561 tctgtggaca gtgactttaa tggctatgtt gaaaaaggcg atttaaataa aaatggggta
     4621 attgatgctt atgatatcag ttatgtttta cgacaattag atggtgggat tgagatacct
     4681 gatgtcgaag aaattgcggg cggtttatcc cttgctgtgg ttaatgaaaa tggcaaggat
     4741 acctatcttc ctggcgatac attaaccttt acacttaaag gtcaagactt aaaaaacatt
     4801 aatgcgttaa gcacaaaaat gtcctttgat tctagcaaat ttgaacttgt cggtcagcct
     4861 gcaaccacga ataatacaaa acaaatggaa aattattcta aatatcggaa acattcaaat
     4921 gatgtggaga atctgtattt agttcttagt aatcaaggaa ataaacaatt gttaaatggt
     4981 tcaatggact tagttacctt taaagttaaa gtaaaagaaa caactcgcgt aaaacgtgcg
     5041 acaactgttg agcagccatt acaatttgat atgagtcaag gcttattagt aggccaagga
     5101 ttccaacaag ccacactttc agatttttct gtaacagtga agcccacaga gctagtagat
     5161 aaagagttat tacaagcgct aattacgcta aatcaagcac gtgtcgaaaa agaatatacg
     5221 cctgaaactt gggcaatttt taaaccagtc ttagatgagg cagtagctgt tctagccaat
     5281 gaacaagcca cacagacaga cgtttctgct gctgtggaaa acctagaaaa ggctgcaagt
     5341 cagttggaaa aaatgcctga tgtagcgaat aaagctgatt tagaaaaagc aattcaagag
     5401 gggctggcga agaaaccaag tgatgggcaa gaattcaccg aagaaactaa aaaagttctc
     5461 gaagactcat tagcagcagc tcaaaaagta tttgctcaag aaaaagttac ccaagaagaa
     5521 atagaccaag cgactaaaac attgcgtgaa gcaattgcac aattaaaaga acaacccgtc
     5581 gccgttgata aggaaacctt aaaagagaaa atcgctcaag ctcgaggaag aaagccggaa
     5641 gaaggatacc aatttacaaa agaaacagaa aaacaattgc aagaagcaat tcaagcggct
     5701 gaagcaatcg tagcgaaaga aacggcgaca aaagaagaag tctctgaggc tctaaacgca
     5761 ttggaaactg caatggctca attaaaagaa gtaccccttg taaataaaga ccaattacaa
     5821 gaagtagtca aacgagcgca gcaagtcact ccaagtgaag ggcaccaatt tactgcctcc
     5881 tcgttacaag atttacaaaa agcgctttta gcagctaaaa acacattgga aaacccagca
     5941 gctaatcaaa aaatgattga tgaagcggtt gctgaattaa ctagtgccat cgatgggtta
     6001 caagaagaag cgttagttac agataaaaaa gccttagagg caatgatagc caaagcaaaa
     6061 gcaatcaaac catctgccgg aaaagaattt accagcgagt ctaaagcgcg cttaactgaa
     6121 gcaattgacc aagcggaagg gattttagct gataaaaatg ctcggcaaga acaaattgat
     6181 actgctgaaa aaaatgtaaa aactgctttg gatagtttag aggaacaagt ccttcaagcg
     6241 gataaaacaa agttgagaga actgcttcaa aaagcagaaa ccttgaaacc taaagcagga
     6301 aaacaattta caaaagcatc gcaagaagct ttagctgaag caattaaaca agcaaaagca
     6361 cttgttgagg acccaagtgc gacgcaagaa gctgtggaca aatgtttaag tattttagca
     6421 caagccattg aagcaatggc agaagagcca atcagtagca actctacagg caacaataga
     6481 aatcatggca cggttagcgg gactggtagc gtaaccagtc caggaaaggg cacagcagca
     6541 ggtggaacga caacaaaaac caccacttct ggtactttgc caaaagcaaa tgaagttgtt
     6601 tcgccaatct ggtcaatcag tggttttcta ttgatagtaa gtattggttt aggaaaatta
     6661 ttcttcaaaa ataaaaaaga caaaattagc gtatcattaa cttacaaggc gcatttgtac
     6721 aaaaacagtg tgcaaatgcg caagtaagta ataggagagg atttttacga atgaaaagaa
     6781 agaaaatcaa gaatcaacta cttgttttaa caagtattct cgttcttctg agtttggaag
     6841 tcgctccagt tgttacgttg gctgcagaat taccaagtag ctcgctacaa acagctctgt
     6901 cctcggaaac gacaattact tcggaagaaa aagtaattga aacaaccgaa acaaccgaaa
     6961 caactgaaac aactgttgct acatcgacaa cgtccactag tagttcgtca tctgaatcaa
     7021 atagttctac cgatacgact accgaatcaa cgagtcattc aacgacagaa acgacaacca
     7081 caaatactag ttctgaaaca aaaaaagaac ctacagagcc aacggtatca tcagaaatca
     7141 cgcagcctat tgaacaatcg caaccaccac aagttcaacc accacaagtt cctgtgacca
     7201 agcaagaacc tgaagaacct attcaagttc ctgaagccac caataacgtt gttgaagaaa
     7261 atcaggctgt atcgttaaat ccgtccctca aagtagatga aatagcttct tcaaatttaa
     7321 aaggctacga actgccactg ttgtcgtctt ttggcgaaaa gaaacgggca gtcgtggtgg
     7381 ctgaagcatt aagacacatt gggaaaacaa aaaaagaatt taatttgacg gagcaagcat
     7441 tgaccagtag tttccttgcc caaaaaattt accaacaatt atttaaaata gacattggca
     7501 gtacaccgca agaacaaatg acatttggta aagttcgttc tatagaggag gcagaacctg
     7561 gtgatctgat tttttggcaa acagctgaag gaaaaacgct tcaaaatggt gtttatcttg
     7621 gccaaggaaa atatttaatt gccgcagcgg aagcggattc taaagagaaa ccagaagtaa
     7681 tcgctcagtt agagaatatc tatactgcca aacaacaacc agactcaaaa gaggaaaaac
     7741 gcttggtagt gactaatcct tttaaggagt tcatattaac ggagtatggc aaagaagttt
     7801 tagcaacata tggtgcgtca tttgaaatgc agaagtcaga acaagccaca gcgtttatta
     7861 aaaaaattgg tgagacagcc agagaacttg gcgaaaaata cgatgttttt gcatcagtga
     7921 tgatagctca ggctatttta gaaagtggct ctggcgaaag tcaactagcc aaagaacctt
     7981 attataatct ctttggcgtg aaaggttcgt tccaaggaaa tagtgttagc ttttcaacaa
     8041 aagaggctga tcagaggggc caactttata caatttccgc tgggtttcgc gattacggtg
     8101 gttataatga ctcattgcaa gattatgttc aattactccg acaagggatt gacggaaatc
     8161 aagattttta taaaccagcg tggcgttcgg aagccaaaaa ctaccttcaa gcaacgcgtt
     8221 ttttaacagg taaatatgca acagacaagc aatacgataa taaattaaat tcgttaattg
     8281 cggtttataa cttaacgcaa tttgatttac caaaaacagc agacggtttg attatccaat
     8341 ctaaaaatga gctgtcggaa gcggaacagc aacaaatgca ttttccagtc tatgatggga
     8401 tcaattataa tcgaagtggt agctatcccg tgggccagtg tacgtggtat gtctataatc
     8461 gtttcaaaca gttgggcact tctgtggatg aatttatggg aaatggcagt gactggggaa
     8521 gaaaaggacg tgcattaggc tatcaagtta gttcattgcc taaagctggt cgtgcgatta
     8581 gtttccaacc aggagttgct ggcgcagata atcaatatgg acatgttgct tttgttgaag
     8641 cggtcacttc tgatggaatc attatttctg aaagcaatgt catcaatgat caaacgattt
     8701 cgtatcgtgt cttacctaat gcaattgctt atagtagtgg cgtgacctac attggcgctt
     8761 gatcgactca ttcaacagga agaagtgtgg atgtttaagt aaaaaattag cacaatgatc
     8821 catgtgtgaa ctaacaaatt aaattaacca gaatcgacca atgaattgat tttgtcatgt
     8881 ataaaatgac aagaacagtt tggcggttga ttctttgttt ttcatcaacg aagagacaat
     8941 agtcctcatg attcgttaga aaaagatgaa tagtccaaag tactctttct tgatcctttg
     9001 ttattttatg tttttgtttg caggaaacta ctgaaatcgc tatactaaat ttatgtgaat
     9061 atactaacag acaatcaatt ttttatctct tttattggtg tataaattga ttgaacatta
     9121 taatcatttg tcttttgttg tgtaatttta tatcttcttg agaaagggat gagtgaacaa
     9181 atggctattt atatattaga agaccaaatt attcaagcaa aagcgttaga agcattgtta
     9241 acaaatatcc tacattcaag aaatatttat aatgaaacaa tccatttatt ttcacgttca
     9301 gatgaattat tacaagtggc acaccaggac gcccaactaa atatcttttt cctagatatt
     9361 caaatgaaca atcatatcca ggcaggattt gaggttgcta aagaaatcag aaaaacagac
     9421 agtgaaagtc tgattgtatt tatttctact cacacagaat tagttttaac ttcctacaaa
     9481 tatatggttt cagctcttca atttattcaa aagaacgtgg attttctaga tttccaaaaa
     9541 gaggtcgaaa catgtgtcga tgcatatatt caacaaaaag aaaatataaa gacaaaaagt
     9601 gaatatatta tcattaactt aaaagcgtct tctataaaaa tggatattaa tgatatttat
     9661 ttctttcaaa cggaatacga tcatcgtgtg tcaatggttg gtaaaaattt taaaagagaa
     9721 ttttatggaa cgttatcaaa aattgaacaa ctgcatccag atttaattag agtccatcaa
     9781 tcaatcatca tcaataaaaa atatgcgtca aaattaaatt ataaaacgca tcttttaact
     9841 atgagagacg gaacggaagt accagtctca agaagatatt atactcaggt caaggcacta
     9901 tttcttactt agggagggat aatgactaat taaggaatta tctatctatt agtcgctata
     9961 ttcgttataa tttagtgcaa tacttgaaga ggagggcgat atgctaatcg attggattct
    10021 aaaaaatatt atggatatgg atcaggaaga tcaatcagga aaaacacaat ggacaaagta
    10081 ttatctaacc gtttattttt ctggcttatt taattttctg atgattctga ttttatcagt
    10141 tttatttggg acgttaagcg aaacctttat tgtatacgtc gtactgattt ttttacggcc
    10201 tgtcgcaggt ggctggcatg caaaaactaa atggctctgt cgtctagaaa gcattgttat
    10261 ctatgtcgcc ataccatttg tattgaaaaa ttcttctgtg agcttaccgt ttatttataa
    10321 aattctattg atgtgcctct tagtcgtatt attttattgg tatgcgccac aaggaacagc
    10381 aatcgaacct gttcagccat ctgatttaaa cgtgctcaaa aagcaaagcc ttataagggt
    10441 gtgtttactt attttatgta gtctgtttgt caaagaaaag attgcttcag taatactcta
    10501 cggtctcgtc atccaaggtc tgatgatact ccctgtaaca aaaaatttaa ttgaaggaag
    10561 tgtttttatg aaatttggta aaaaaataat taaaaatgtt attgaaaaaa gagttgcaaa
    10621 agtcagtgat ggtgtgggaa ctaagcctag attaaatcaa aattcgccca atatatttgg
    10681 acaatggatg ggacaaactg aaaaacctaa aaagaatatt gaaaaatgat tttgtcgtta
    10741 ttagctacta acgttttgct tgtatctagc tttatcgttt ttgtcttttt acgagtaaca
    10801 ttgatcaaga ttgaatgtaa aataccgtta ctttcattgc ttattgtcat taatctttgt
    10861 tcgtttgcgg cattaatgtt gggctactct tggttgattt atgcgctgac agtcgttatt
    10921 tttacaggat ttttactcat tcacaaaaag aggttctcaa tttttaaagc gatattttta
    10981 tccgttttta cattgcttat ggtttcgttt atcaattaca cggagcaaac gattttaagt
    11041 gttttttttc aacagattta tcaaaataaa ttattatgga ttgcctcaaa tgttcttctg
    11101 ttgcttataa atatctggat tgctttaaaa attcccaata gtgttttttt aagattaaat
    11161 cgtgtgttag aaaatagtcg aatttttttt ggttgtttac ttttattgtt gattctgttg
    11221 ttactttttg tgtttttgat ttcgccagag atttcacctg actttatgcg aggatttgtc
    11281 acggtaaata gttctaaatt ggagttatta ataagtgtag gtttattttt aattctgatt
    11341 ggcttagtca ttgaagctta tttggaagaa caacgtatca acactcaatt attgaataat
    11401 ttaacgattt atactgaaaa aatagaatcc attaacgaag agctagcgat gtttcgtcat
    11461 gattataaaa atttattgta tagtttacaa attgctattt catacgaaga tattctggaa
    11521 atcaaaagaa tttatgaaga aacgattgca ccaaccaaaa aaattattga taatgaagaa
    11581 tttgaactta tgaagttaaa tcgtttgaaa aatatggaac ttaaggcact cataagtatg
    11641 aaaattaata ccgcaaagca agcaaaacta aaagtgattg ttgatgtgcc agaagtattt
    11701 attctcgata catcaatcga cttagtggtt gtgattcgtt tgttggctat tctattagat
    11761 aacgcgattg aaaacagtgc aaaatcagaa ttgaaaatgt tcgctatctc aattttcaat
    11821 aaaaatgaaa cacaagagtt tgtgataaca aatagtgtcc aagccgaatt tgattttagg
    11881 gttatgaaga aaaccaaatt tagttctaaa agtaacccag aagagcacgg ttggggattg
    11941 ttatatgtaa aagaaattgt tgatttttca gatcaatttg acttgcaaac gtccttcaat
    12001 gaaggatcgg ttactcaaca tttaattatt gaaaaaaatc ataacagtaa aaaagttgtt
    12061 aacgaatgaa tttgttaaca acttttttgc tatggtattg agttatgagg ggcaatacag
    12121 ggaaaaatgt cggctgatta aggaatttag atagtgccgg ttaggtagtt gtctataatg
    12181 aaaatagcaa caaatattta cgcagggaaa ggggcggtcg tttaacggga aaaattaggg
    12241 aggataaagc aatacttttg ttgggaaaag aaataaaagg aaactgggga aggagttaat
    12301 tgtttgatga agggaaataa aattttatac attttaggta caggcatctt tgttggaagt
    12361 tcatgtctat tttcttcact ttttgtagcc gcagaagaac aagtttattc agaaagtgaa
    12421 gtttcaacag ttttatcgaa gttggaaaag gaggcaattt ctgaggcagc tgctgaacaa
    12481 tatacggttg tagatcgaaa agaagacgcg tgggggatga agcatcttaa gttagaaaag
    12541 caaacggaag gcgttactgt tgattcagat aatgtgatta ttcatttaga taaaaacggt
    12601 gcagtaacaa gtgttacagg aaatccagtt gatcaagttg tgaaaattca atcggttgat
    12661 gcaatcggtg aagaaggagt taaaaaaatt attgcttctg ataatccgga aaataaagat
    12721 cttgtctttt tagctattga caaacgtgta aataatgaag ggcaattatt ttataaagtc
    12781 agagtaactt cttcaccaac tggtgacccc gtatcattgg tttataaagt gaacgctaca
    12841 gatggaacaa ttatggaaaa acaagattta acggaacatg tcggtagtga agtaacgtta
    12901 aaaaactctt ttcaagtaac gtttaatgta ccagttgaaa aaagcaatac gggaattgct
    12961 ttacacggaa cggataacac aggggtttac catgcagtag ttgatggcaa aaataattat
    13021 tctattattc aagcgccatc actagcgaca ttaaatcaga atgctgttga cgcctatacg
    13081 catggaaaat ttgtgaaaac atattatgaa gatcatttcc aacgacacag tattgatgat
    13141 cgagggatgc ccatcttgtc agttgttgat gaacaacatc cagatgctta tgacaatgct
    13201 ttttgggatg gaaaagcaat gcgttatggt gaaacaagta caccaacagg aaaaacgtat
    13261 gcttcctctt tagatgtagt tggtcatgaa atgacacatg gtgtgacgga acatactgcc
    13321 ggtttagaat atttaggaca atcaggtgcc ttgaatgaat cttattctga tttgatgggt
    13381 tatattattt cgggtgcatc taatccagaa attggtgcgg atactcagag tgttgaccga
    13441 aaaacaggta ttcgaaattt acaaacgcca agtaaacacg gacaaccaga aaccatggct
    13501 caatacgacg atcgagcacg gtataaagga acgccttatt atgatcaagg cggtgttcat
    13561 tataatagtg gaattattaa tcggattggt tacaccatta tccagaactt aggcattgaa
    13621 aaagcacaga ctattttcta cagctcgtta gtaaattact taacacctaa agcacaattc
    13681 agtgatgctc gtgatgcgat gcttgctgct gcaaaagttc aatatggcga tgaagcagct
    13741 tcagtggtgt cagcagcctt taactctgct ggaatcggag ctaaagagga tattcaagta
    13801 aaccaaccaa gtgaatctgt tctggtcaat gaatgaaaaa aattccccaa ttaaataaaa
    13861 atggataagg agtggcataa tcttatgaaa aagttctcca tacgaaaaat tagtgctggt
    13921 tttttgtttc tgattttagt aactttgatc gccggtttta gcttgtctgc aaatgcagaa
    13981 gagtatatcg ttcctgccga aagtcattca cgacaaaaaa gatcgttact ggaccctgaa
    14041 gacagaagac aagaagtggc agatacaacc gaagcgcctt ttgcgtcaat cggaagaatc
    14101 atttcccctg ccagtaaacc aggctatatt tctttaggaa caggctttgt tgttggaact
    14161 aatacaattg tcaccaataa tcatgtggct gaaagtttta agaatgccaa agtattaaat
    14221 tcgaatgcca aagatgatgc ttggttttat ccaggtcgag atggcagtgc gacaccattt
    14281 ggtaaattca aagtgattga tgtagctttt tccccgaatg cggatattgc ggtagtgact
    14341 gtcagcaaac aaaacgatcg tccagatggc ccagagttgg gagaaatttt aacgccattt
    14401 gttttgaaaa agtttgaatc ttcagatacc catgtcacaa tatcaggcta tccaggtgag
    14461 aaaaaccaca cacaatggtc tcatgaaaat gatttgttta catctaactt tacagactta
    14521 gaaaatccat tactatttta tgatatcgat acaacaggtg gtcaatctgg ttccccaatc
    14581 tataatgctc agtttgaagt agttggtgtt cattccaatg gcggcattaa gcaaacagga
    14641 aaccatggtc aaagactaaa tgaagtgaat tataacttta ttgtcaatcg agtgaatgaa
    14701 gaagaaaata aacgtttatc cgctgtgcca gcagcgtaaa gaaccataaa aatactcgga
    14761 atttccagaa tcacgggaaa tctcgagtat ttttgttttt taagatagtg taagttacga
    14821 taaaagtacc ttgtaattat cggttaaaag catataatag tgctgaaaag aaggcaaata
    14881 atccgattaa gttagtattt ctaaaccatc ataactcgta atgatttcat gcttttgaga
    14941 taaagccgcc atctccgcat atgacaagcc gccattgtga gaaaaatggt tggcaacgta
    15001 aatcgtttta tctgtgacga gttttctttc ttttaattct gtaattaatt ttaaattttc
    15061 ttcccaattc atatgactat tgccagtttc gtttgtttga ctagtacaat ctaaagaaac
    15121 aatactaaga agtaagtggc tcttttcaag atattcaaac atttctgacg taaagtaacc
    15181 tgtatcatgg gtggataaaa aagcatcttt accatcgtct ataacgaaaa taaaacaatc
    15241 ttcactgaaa tttccatgtt gtgcaggaag gggataaatc gtatagttcg caatagtaaa
    15301 acatttgtag ggctgaataa cctgataatg taatcgggta tcatcttgcc gaccttctaa
    15361 atcaaaggcg cgctgataaa acgtcttaac tgcttcattt ccgtaaacag ttaaacgatt
    15421 gggaatatct aatgcataac cagacattcg ataagccaaa tcctcgccgt aaaaatgatc
    15481 ggaatgccaa tgagagatta gtaaagagtc aaagtctgca aaacacaagt cgtactgcaa
    15541 caggtgtaaa taagaatccc ctggaaaatc aatcagcagg acatcatcaa taattaattg
    15601 agtttgtgta cgaatttctc gtcctttttt ctctcgagcg tacttacata atttacaatt
    15661 acaaaaaatt cctggaatcc gttctgctgc acccgtacct aaatagttga ttttcattgg
    15721 gagtacctaa cctttctttg acattcttca tacttagtag ataacgctga accttaaagt
    15781 aaatgggcat ggaaactgaa acatttgttg tgtccatctt acctttttta gaaaagaatt
    15841 gaaatggaat ttcttaagta aatttgcgta aaatagaaaa agctagacgc cttttttaat
    15901 aagctgaatt tgttgtgaat gttcatgcta tttccgagaa aaagttttac caaaggcact
    15961 ttcatattca tctgctatta gttatagaaa aataacaaga tggacatagc ttattagagc
    16021 aaaaataact acgctattga taaagagtga ggcgtgtttt gaacaggttg cgtgggcaat
    16081 tgaatttgaa taaaagggat gacaaaagat gactattgaa aaattagaat atttttatac
    16141 cattgcaaaa tataatagta tttccaaagc agcctctgaa cttcatgtta gtaaatcaac
    16201 cttaagtgcg tcattaaaag atttggaaag tgaattgggc catttacttt ttgaccgtaa
    16261 cgggaattct ttgacgttaa attcctatgg tgataaaatc gtccaatctg tatatatcat
    16321 tttaaacgag gccaagaaaa tgaaacttaa tttgcatgaa atgattgaga atccagtgat
    16381 gcgtttaggt tttggaaata cgtccttgat gtataaagtg acagaaaatg aggatcaact
    16441 gaatcgtttt tgggaatgtt accatggttc atcgtttgag ttattgaata aattggagaa
    16501 tcatgagttg gattttgtga ttacttctgc agatgtgaat agtccagttt taaagaaaga
    16561 acaattaatt gaactaaaaa tgtatctttg tgtttcaaga gaaattaaac aagaaattga
    16621 ggaagaaggc ttcacctgtt tgaccaacta tccatttcta tttttgccac atcacttaga
    16681 tcatttagaa gctaccaaga gtgtgctaga aatgttgcaa ttaacaagtc cgcttgtttg
    16741 ttgctacgat acgttgatgc ttactcgtct cattgaaaaa agtaaaggag tttatgcggt
    16801 gatctctctt cggaaagaac aactgcagga aattgattct aaactcttct ttttaccgat
    16861 tgaacgaaaa caaaaatttt atttataccg aaatgtttcc agttcggttt ttgtccaacc
    16921 tggtcaaatc aaggcaactt tacaaaagtt gctagagact tagccattaa aattactttg
    16981 gaatagttac ccaaaatagc tttattcgct tagatttact tctgctgcgg ataaggctat
    17041 ttttgttgtt cattgtttaa aagagatgct caattatggg actgttcgat atttctgaac
    17101 ggaatgttca attatttaat aacttaagaa tcgataaatc gtatctatta cggttcaatt
    17161 taaaggggtt ctggtgtata gtttggctat ctaaagattt acttttttaa gtataaaata
    17221 actaaatggc aaggaatata aagaactgtt gatacgtgag tacttgcgat aactgtgtcg
    17281 ttagaagttt aagtgtcatt gttgcttttc ctgttttatg tagttgctag aaaggactgt
    17341 ttttatgatc gatagaaaaa aagttatttt gtatacttgt tgcatgagtt tgtttgtagt
    17401 gaccatggat gttacggttg tcaatgtggc gttaccatcc attcaaagtg attttcacac
    17461 gaatctgtct acattacagt gggtaacaga tgggtacact ttaatggtag catccttatt
    17521 attgttgtct gggtctacag cagatcgaat tggccgtaaa cgagtccttc aattgggctt
    17581 agcctgtttt ggtttagcgt ctttcctatg tgggatttcg caaaccccag ggcaattgat
    17641 cgcgtttcgc atgttgcaag ggattggtgg ttctatgtta aatccggtag caatgtctat
    17701 tattacacag gtatttaccg aaaagttaga acgtgcgaaa gcaattggct tgtggggctc
    17761 tgttacaggg atttccttag gcatgggccc gattattggc ggactaattg tttcttattt
    17821 tagctggcgg tatgtctttt ttgtaaatgt accgatcatt gctgcggcaa ttatccttac
    17881 acaataattt gtacctgagt caaaagtaga gaagacggcg aaaaatgatt ttgttggtca
    17941 agcattgatg attctttttc tatttagttc tatctattcc attatcggac tacctagaaa
    18001 agggcttttc gggccagata ttttaagtac tgggataatc ggctgtttag ccattgtcat
    18061 tttctttatt tatgaatata acattgacaa tccgttaatc aacccgcgtt tctttttatc
    18121 tattccattt acatcggctt cttttttagc tatttttggc tttatcatat ataacggcta
    18181 tttattttta aacacgctat atttgcaaga gatgagaggc ttcagcccgt tggaagctgg
    18241 cttatcaacc attcctttgg cttttgttag ttttcttgtt gccccgagag ccggcgaaat
    18301 ggtagggaga atagggacga aacgtcctat tatgctttgt ggtatttcaa tgttggctgt
    18361 tagcttttta caattatttg taactaaaac aacgcctatg attattttat ttgttattta
    18421 tatcttttta ggcattgggt ttgggatgtt aaattcgccg attaccatta cagcgattga
    18481 aggaatgcca ctttctcagt caggaacggc agcagccatt gcggtgacat gtaagcaaat
    18541 tggcaattct ttaggggttg cgctaccaag tcttttaatt acaaagccta ttactagttc
    18601 gcttactcga acacctttta caaacgtatg gcttttattt ggatgttgcg ccattgcgat
    18661 tatcttttta agttatttat ccaattctcc gctagcgaaa aagtcattgc gcagagttag
    18721 gttttatttt taacaaatca agattttttt gaagggaaag gaagacaaac ttagatgaaa
    18781 aaaataaata accgattagg actcttttta ttttttgttt tactcttttg ggcaaaaacg
    18841 attctggcgt attacctaga tttctcattg ggcgttaagg gcagtctcca gcgagaaatt
    18901 ttatggttca atccagttgc tactacgctg ttattatttg gttttagttt gtattttaaa
    18961 aagcataaaa catttatgct tagcttaact cttttaaatg ttttaaatac attaatttta
    19021 tatttgaata ttatttttta tcgtgaattc actgacttta ttaccatcca atctgttttt
    19081 ggcttttcaa aagtttcaga agggatttct ggtgatttac ttgctttaat aagagtccac
    19141 gatgtctttt attggctaga tactttagtg ctgctcgttt tggtatttta ctcttttaaa
    19201 cagcgacgga atcatcaagt ctttgtgacc aaacctatca acagaagatt ggcgatctca
    19261 attagttgtt taagtgtctt gctcttttcg gttaacttat ttttaagcga aaccgatcgt
    19321 cctcaattgc ttcaaagaat ttttgatcgt aattatattg taaaatatct tggcttggat
    19381 gcattcacag ccatcgatgg tgtcaaaaca gccatgtcaa atgaggtaag agcagaagct
    19441 agttcaaacg aattacctga aatcatgaaa tttaccaagc aaaacaattt accgcttaat
    19501 ccgcagtatg ccgggattgc caaaggaaaa aatgtatttg tgattcattt agaaagtttt
    19561 caacaatttt tgattaatat gaaagtccaa ggccaagagg ttacaccgtt tttaaatcag
    19621 ctctatcaaa acaaagcgac aatcagtttt gataatttct ttcatgaagt agggcaagga
    19681 aaaacgagtg atgcggagaa catgttagaa acaggaacat tcgggctccc gcaaggctct
    19741 ctttttacac aattaggatc agacaatact ttcgaagcgg ctcccgctgt tttaggacaa
    19801 aaaggctata caaccgctgt tttccatggg aatgtgggga gtttttggaa tcgggaccat
    19861 gtgtataaaa acttaggtta tcaatacttt tttgatcggt catatttttc aaaagatgac
    19921 aaaatgctag gttacggtat tttagataaa caattgttgc gtgaatcagc tagtgagctt
    19981 gagcatttac agcagccatt ctatgcgaag tttttaactg tgaccaatca taccccttat
    20041 tacacggatg accaaaactt cccgtttcct aaattgaaca caggcaattc gattgtggat
    20101 gattatgttc gaacagcgca ctatttggat caatcgctag aacaattttt ccattacttg
    20161 caaacaacaa gtttatacaa tcattctatt tttgttattt atggtgacca cttcggtatt
    20221 tcagatgcaa acaacaagga cttatgtaaa gctttcaacc gcgatccaaa aacgtggaca
    20281 aactatgaca atgcgcaatt gcaaagagta cctttgatgt tttacatgcc aggctatacg
    20341 caagggaaaa tcatgcacga atatggtggg gaaattgacg ttttaccgac actgtaccat
    20401 cttttaggtg tcgatgataa aaattatatc cattttggca cggacctttt atctcctcaa
    20461 tataaacaag tggttccttt tagaaatggc gattttgtaa cgcctcaatt ttcttatcta
    20521 ggtggggaaa tctacaataa tcaaggaaaa aaattagacc aagttccagc agatttaaaa
    20581 gcagaagtca cgaaagataa cgattgggtg aaaaaatcgt taagtttatc tgacaaatta
    20641 aatcaggaaa accttttacg tttttataaa ccacaaggat tccaagaagt gcaaccaaag
    20701 gactacaact atgatgtggc ttttgaaaa
//
