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Overview
1.1
1.2
1.3
1.4
2.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP028720.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 142,809 | 163,690 |
Region 1.2 | darobactin | 894,027 | 915,034 |
Region 1.3 | RiPP-like | 1,445,448 | 1,456,491 |
Region 1.4 | cyclic-lactone-autoinducer | 2,316,517 | 2,337,245 |

NZ_CP028721.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | lanthipeptide-class-ii | 28,909 | 51,890 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 142,809 | 163,690 |
Region 1.2 | darobactin | 894,027 | 915,034 |
Region 1.3 | RiPP-like | 1,445,448 | 1,456,491 |
Region 1.4 | cyclic-lactone-autoinducer | 2,316,517 | 2,337,245 |
Region 2.1 | lanthipeptide-class-ii | 28,909 | 51,890 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_CP028722.1 (Enterococcus faecalis)
  NZ_CP028723.1 (Enterococcus faecalis)

Compact view
NZ_CP028720.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 142,809 - 163,690 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
C7I32_RS00915: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
C7I32_RS00880: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
C7I32_RS00880: PT_FPPS_like
Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
Additional weak hits (1):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.64 out of 29.38
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP028720.1 - Region 2 - darobactin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 894,027 - 915,034 nt. (total: 21,008 nt) Show pHMM detection rules used
darobactin: ((cds(PF04055 and (TIGR04085 or SPASM)) and darobactin_precursor) or darobactin_rSAM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase
C7I32_RS04835: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | darobactin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.5 |  | 0.36 | other (other) | arginomycin | Streptomyces arginensis
BGC0000875.4 |  | 0.30 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0000207.5 |  | 0.30 | PKS | chartreusin | Streptomyces chartreusis
BGC0000872.5 |  | 0.30 | other (other) | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405
BGC0001076.5 |  | 0.30 | other (nucleoside) | liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N | Streptomyces sp. SN-1061M
BGC0002359.3 |  | 0.29 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0001835.2 |  | 0.25 | PKS | gynuellalide | Gynuella sunshinyii YC6258
BGC0001812.3 |  | 0.25 | PKS | tylactone | Micromonospora chalcea subsp. izumensis
BGC0000804.5 |  | 0.24 | saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000907.5 |  | 0.24 | other (other) | lincomycin | Streptomyces lincolnensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000883.5 |  | 0.36 | other (other) | arginomycin | Streptomyces arginensis
BGC0000875.4 |  | 0.30 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0000207.5 |  | 0.30 | PKS | chartreusin | Streptomyces chartreusis
BGC0000872.5 |  | 0.30 | other (other) | A-90289 A, A-90289 B | Streptomyces sp. SANK 60405
BGC0001076.5 |  | 0.30 | other (nucleoside) | liposidomycin B, liposidomycin A, liposidomycin C, liposidomycin Z, liposidomycin H, liposidomycin G, liposidomycin L, liposidomycin M, liposidomycin K, liposidomycin N | Streptomyces sp. SN-1061M
BGC0002359.3 |  | 0.29 | NRPS | dudomycin A | Streptomyces albus subsp. chlorinus
BGC0001835.2 |  | 0.25 | PKS | gynuellalide | Gynuella sunshinyii YC6258
BGC0001812.3 |  | 0.25 | PKS | tylactone | Micromonospora chalcea subsp. izumensis
BGC0000804.5 |  | 0.24 | saccharide | acarviostatin I03, acarviostatin II03, acarviostatin III03, acarviostatin IV03 | Streptomyces coelicoflavus ZG0656
BGC0000907.5 |  | 0.24 | other (other) | lincomycin | Streptomyces lincolnensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38
Confidence: medium
Additional weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.86 out of 29.38
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.09 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator

NZ_CP028720.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,445,448 - 1,456,491 nt. (total: 11,044 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase
C7I32_RS07485: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001510.5 |  | 0.31 | other (other) | anisomycin | Streptomyces hygrospinosus
BGC0000770.4 |  | 0.31 | saccharide | lipo-oligosaccharide | Campylobacter jejuni
BGC0000762.3 |  | 0.27 | saccharide | exopolysaccharide | Rhizobium leguminosarum bv. viciae
BGC0000298.5 |  | 0.25 | NRPS | aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C | Microcystis aeruginosa NIES-98
BGC0000795.3 |  | 0.24 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000806.5 |  | 0.24 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001412.3 |  | 0.24 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0001894.2 |  | 0.21 | saccharide | heteropolysaccharide (HePS) | Lactobacillus plantarum
BGC0002550.2 |  | 0.19 | PKS | lobophorin CR4 | Streptomyces olivaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001510.5 |  | 0.31 | other (other) | anisomycin | Streptomyces hygrospinosus
BGC0000770.4 |  | 0.31 | saccharide | lipo-oligosaccharide | Campylobacter jejuni
BGC0000762.3 |  | 0.27 | saccharide | exopolysaccharide | Rhizobium leguminosarum bv. viciae
BGC0000298.5 |  | 0.25 | NRPS | aeruginosin 98-A, aeruginosin 98-B, aeruginosin 98-C | Microcystis aeruginosa NIES-98
BGC0000795.3 |  | 0.24 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000806.5 |  | 0.24 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001412.3 |  | 0.24 | saccharide | polysaccharide C | Bacteroides fragilis
BGC0001894.2 |  | 0.21 | saccharide | heteropolysaccharide (HePS) | Lactobacillus plantarum
BGC0002550.2 |  | 0.19 | PKS | lobophorin CR4 | Streptomyces olivaceus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (2):
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.43 out of 32.93
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production

NZ_CP028720.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,316,517 - 2,337,245 nt. (total: 20,729 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0001246.3 |  | 0.30 | PKS | trans-resorcylide | Sarocladium zeae
BGC0000045.3 |  | 0.29 | PKS | dehydrocurvularin | Aspergillus terreus
BGC0000676.5 |  | 0.29 | terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0001246.3 |  | 0.30 | PKS | trans-resorcylide | Sarocladium zeae
BGC0000045.3 |  | 0.29 | PKS | dehydrocurvularin | Aspergillus terreus
BGC0000676.5 |  | 0.29 | terpene | aphidicolin, aphidicolan-16β-ol, 3-deoxyaphidicolin, 17-deoxyaphidicolin | Phoma betae
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
Additional weak hits (1):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.02 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_CP028721.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 28,909 - 51,890 nt. (total: 22,982 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
C7I32_RS15460: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
C7I32_RS15470: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 1.00 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.50 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 1.00 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.50 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for C7I32_RS15470

C7I32_RS16360
Leader:
MLLSMNITVTEIFM
Core:
K T Y D Y R G S V I K E G N K T T S I A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K R T Y M L G K E I Y R
Core with dehydrations:
K Dhb Y D Y R G Dha V I K E G N K Dhb Dhb Dha I A Y V Q Cys A Cys G Cys L A Dha R M Dha Dha D Dha D K Y K Cys Dha W Cys K R Dhb Y M L G K E I Y R

#### antiSMASH-DB 4.0 matches for C7I32_RS16360

100.0%
NZ_CP028721.1 and 1 other:
NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12570_lanthipeptide
Lanthipeptides: C7I32_RS16360_lanthipeptide
1
K T Y D Y R G S V I K E G N K T T S I A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K R T Y M L G K E I Y R
57
K T Y D Y R G S V I K E G N K T T S I A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K R T Y M L G K E I Y R
1
K T Y D Y R G S V I K E G N K T T S I A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K R T Y M L G K E I Y R
57
15.8%
NZ_AP019008.1 and 1 other:
NZ_BDDX01000012.1 Lanthipeptides: FF306_RS05510_lanthipeptide
Lanthipeptides: FF306_RS00060_lanthipeptide
20
A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K
46
+Y V C G C+ R+ ++K K C
3
S Y V L C T P G C I T G R L M G C N N K T K T C H C H
29
15.8%
NZ_JXCW01000008.1:
Lanthipeptides: RZ55_RS07215_lanthipeptide
20
A Y V Q C A C G C L A S R M S S D S D K Y K C S W C K R T Y
49
+Y V C G C+ R+ ++K K C ++
3
S Y V L C T P G C I T G R L M G C N N K T K T C H C H S S H
32
with 3 more sequence matches
14.0%
NZ_KV815277.1:
Lanthipeptides: allorf_240001_240225_lanthipeptide
28
C L A S R M S S D S D K Y K C S W C K R T Y M
50
C L+ S + +C S C R+Y
2
C L S G A A S P S T P T R E C S E C S R S Y T
24
14.0%
NZ_KZ859514.1:
Lanthipeptides: DPQ64_RS19145_lanthipeptide
15
K T T S I A Y V Q C A C G C L A S R M S S D
36
K T I + C+C C+ S+ D
22
K I T G I W S L D C S C T C M C S Q W C G D
43
10.5%
NZ_CM002330.1 and 4 others:
NZ_CP085885.1 Lanthipeptides: allorf_5880464_5880601_lanthipeptide NZ_CP099610.1 Lanthipeptides: allorf_5773509_5773646_lanthipeptide NZ_RHRT01000002.1 Lanthipeptides: allorf_000661_000798_lanthipeptide NZ_RHRW01000002.1 Lanthipeptides: allorf_440068_440205_lanthipeptide
Lanthipeptides: allorf_5814187_5814324_lanthipeptide
15
K T T S I A Y V Q C A C G C
28
K+T I+++ C A C
4
K S T G I S F L H C A H H C
17
C7I32_RS15475
Leader:
MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS
Core:
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
Core with dehydrations:
G D V Q A E Dhb Dhb P A Cys F Dhb I G L G V G A L F Dha A K F Cys

#### antiSMASH-DB 4.0 matches for C7I32_RS15475

100.0%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
85.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T I G L G V G A L S A C
1
G D V Q A E T T P V C F T I G L G V G A L V S A A G C
27
77.8%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide
Lanthipeptides: IKS_RS03655_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G V G+L S A C
1
G D V Q A E T T P V C F T V G L G V G S L V S A S V C
27
with 108 more sequence matches
Only the first 10 are displayed here.
74.1%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide
Lanthipeptides: IKS_RS03660_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G+G+L S A C
1
G D V Q A E T T P V C F T V G L G I G S L V S A S V C
27
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10230_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P I C G F T I G I G I G A L A S V K W C
28
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10250_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P L C G F T I G I G I G A L V S V K W C
28
70.0%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide
Lanthipeptides: COK11_RS25885_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T I G L G+G A L S A C
1
G D V K P E T T P A C L A G F T I G L G I G A L A S A A G C
30
66.7%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T+G L G+G A L S A C
1
G D V K P E T T P A C L A G F T V G L G I G A L A S A A G C
30
63.0%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08035_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q E T+P A C T I G+G+G S F C
1
G D V Q P E T S P A C V T I G I G I G I G I S K L F C
27
59.3%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide
Lanthipeptides: OF830_RS26725_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V Q E T T P A C T L G +F S K+C
1
S D V Q P E T T P A C V T-A L T T G I I F S I K W C
26
58.6%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide
Lanthipeptides: OF830_RS26730_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
D V Q E T T P A C F T I G V +F S + C
1
S D V Q P E T T P A C A V A F T I G A T V--I F S V R N C
28
57.1%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11325_lanthipeptide
2
D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
D V Q E T T P C F +G+G+G A+ S A C
2
D V Q P E T T P V C G F F V G V G I G A I I S A T A C
28
55.6%
NZ_JACSPU010000002.1:
Lanthipeptides: H9630_RS06775_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V E T T P A C G L F S K F C
1
S D V A P E T T P A C-V A A F A T G L L F S I K F C
26

#### MIBiG 4.0 matches for C7I32_RS15475

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T T P A C F T I G L G V G A L-------F S A K F C
27
T P A + L G+ A+ S A F C
1
T D P A V T G L I L G I V A I Q A G V A V G V S A A F C
28
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
8
T P A C F T
13
T P C T
8
T P G C K T
13
7.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
9
P A C F T I G
15
P A C T+
38
P A C H T L S
44
C7I32_RS15480
Leader:
MENLSVVPSFEELSVEEMEAIQGS
Core:
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
Core with dehydrations:
G D V Q A E Dhb Dhb P V Cys A V A A Dhb A A A Dha Dha A A Cys G W V G G G I F Dhb G V Dhb V V V Dha L K H Cys

#### antiSMASH-DB 4.0 matches for C7I32_RS15480

100.0%
NZ_AP026721.1 and 34 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide
Lanthipeptides: PO855_RS02210_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
93.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide
Lanthipeptides: BEH_RS02105_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V S L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V S L K S C
44
90.9%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide
Lanthipeptides: BEH_RS02110_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V+L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V T L K S C
44
with 107 more sequence matches
Only the first 10 are displayed here.
86.4%
NZ_JH791802.1 and 5 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptide NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide
Lanthipeptides: IKS_RS30065_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A S S A A C G W V G G G I T G V T V V++L K C
1
G D V Q A E T T P V C A I A A T T A A S S A A C G W V G G G I A T G V T V V I T L K S C
44
84.1%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26130_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S C G G G I T G V T V V V S L K H C
1
G D V Q A E T T P V C A I A A T A A A S S G I C A A T G G G I A T G V T V V V S L K H C
44
81.8%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide
Lanthipeptides: COK11_RS25880_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S C G G I T G V T V V V S L K C
1
G D V Q A E T T P V C A V A A T A A A S S G V C A A T G A G I A T G V T V V V S L K S C
44
77.3%
NZ_MIFM01000001.1 and 1 other:
NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide
Lanthipeptides: BHL22_RS00425_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V+ S S A A C G W V G G I T G V T V V V+L K C
1
G D V Q A E T T P V C A V S V A T M T S S A A C G W V A G G I A T G V T V V V T L K S C
44
72.7%
NZ_CP062165.1 and 5 others:
NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide
Lanthipeptides: JNUCC31_RS17165_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A V A A T A A S S A C V G G G I G V T+V+++K C
1
G D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
72.7%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11330_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P V C A V A A T A A S S A C V G G G+ G V T V V++L K C
1
A D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G V A V G V T V V L T L K T C
44
70.5%
NZ_KB946334.1 and 1 other:
NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide
Lanthipeptides: UC7_RS10245_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q A E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10240_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q V E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_LN831278.1:
Lanthipeptides: BN1360_RS08835_lanthipeptide
2
D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P+C A V A A T A A S S A C V G G G I G V T+V+++K C
2
D V Q P E T T P I C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
65.9%
NC_014098.1:
Lanthipeptides: BTUS_RS14190_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P+C A A T A S S A A C V G G I G V T+V+++K C
1
G D V Q A E T T P I C Y T A A T V T A S S A A C A G V G A G I V A G V T I V L T I K R C
44
allorf_32905_33036
Leader:
MVGLNEERETKLKRRRPVEQSETNYS
Core:
S F R V W P C S W Y K K L F V F K
Core with dehydrations:
Dha F R V W P Cys Dha W Y K K L F V F K

#### antiSMASH-DB 4.0 matches for allorf_32905_33036

100.0%
NZ_CP028721.1:
Lanthipeptides: allorf_32905_33036_lanthipeptide
1
S F R V W P C S W Y K K L F V F K
17
S F R V W P C S W Y K K L F V F K
1
S F R V W P C S W Y K K L F V F K
17
94.1%
NZ_JAQKZU010000014.1:
Lanthipeptides: allorf_35422_35553_lanthipeptide
1
S F R V W P C S W Y K K L F V F K
17
S F R V P C S W Y K K L F V F K
1
S F R V C P C S W Y K K L F V F K
17
31.6%
NZ_CP086142.1:
Lanthipeptides: allorf_039242_039433_lanthipeptide
2
F R V W P C S W Y K K L F V
15
F W C S+ ++F V
3
F T S W N C S Y K L Q I F V
16
with 3 more sequence matches
17.2%
NC_014098.1:
Lanthipeptides: allorf_2904154_2904300_lanthipeptide
6
P C S W Y K K L F V F
16
P C S + +F V
9
P C S G F S A V F V L
19
15.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
1
S F R V W P C S W
9
S +V W C S W
4
S I Q V W Q C S W
12
8.6%
NZ_CP101913.1:
Lanthipeptides: allorf_1841460_1841675_lanthipeptide
1
S F R V W P C S
8
+F R++P C S
50
T F R L F P C S
57

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.49 out of 32.93
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78
Confidence: strong
Additional weak hits (5):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.86 out of 30.22
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.02 out of 29.65
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.13 out of 27.18
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.18 out of 19.52
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

C7I32_RS16360 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 6346.1 Da
  Molecular weight: 6350.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6368.3 Da N = 1
    6386.3 Da N = 2
    6404.3 Da N = 3
    6422.3 Da N = 4
    6440.4 Da N = 5
    6458.4 Da N = 6
C7I32_RS15475 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 2630.3 Da
  Molecular weight: 2632.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2650.0 Da N = 1
    2668.0 Da N = 2
C7I32_RS15480 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 4017.0 Da
  Molecular weight: 4019.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4037.6 Da N = 1
    4055.6 Da N = 2
    4073.6 Da N = 3
    4091.6 Da N = 4
    4109.6 Da N = 5
allorf_32905_33036 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 2184.2 Da
  Molecular weight: 2185.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2203.6 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
LexA variant 3 | Repressor of DNA damage response