LOCUS       NZ_CP036455            25163 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Streptomonospora litoralis strain M2 chromosome, complete genome.
ACCESSION   NZ_CP036455
VERSION     NZ_CP036455.1
KEYWORDS    RefSeq.
SOURCE      Streptomonospora litoralis
  ORGANISM  Streptomonospora litoralis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 5724192)
  AUTHORS   Khodamoradi,S., Hahnke,R.L., Kaempfer,P., Schumann,P., Rohde,M.,
            Steinert,M., Luzhetskyy,A., Wink,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2019) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.3x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004323735.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,076
            CDSs (total)                      :: 5,002
            Genes (coding)                    :: 4,957
            CDSs (with protein)               :: 4,957
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 6 of 46
            Pseudo Genes (incomplete)         :: 39 of 46
            Pseudo Genes (internal stop)      :: 2 of 46
            Pseudo Genes (multiple problems)  :: 2 of 46
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:19:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5041450
            Orig. end                         :: 5066613
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="13"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25163
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15163](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15163
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(157..879)
                     /locus_tag="EKD16_RS21330"
                     /old_locus_tag="EKD16_21820"
     CDS             complement(157..879)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.5"
                     /locus_tag="EKD16_RS21330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21820"
                     /product="HAD family hydrolase"
                     /protein_id="WP_207391365.1"
                     /sec_met_domain="HAD_2 (E-value: 2.4e-14, bitscore: 52.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPRCLVLWDVDHTLIETRGVGSTVFREAFEKATGATMSAGMATA
                     HGHTEPVLLEKTLELNGIKDREEGLFERFAAAQADGYRARSDELRERGRVLPGVEEALG
                     ALATEPGVMQSALTGNTRRAAQVKLSAFGLDRHLDLAVGAYGDDDSYRPRLVEVALARA
                     AERGGMPVPRERAVLIGDTPKDIAAAREAGVGVIAVASGTSSVDELTEVGADLVLGTLE
                     SVDIRDLVGRVLTVRAGE"
     gene            963..2171
                     /locus_tag="EKD16_RS21335"
                     /old_locus_tag="EKD16_21825"
     CDS             963..2171
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="EKD16_RS21335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21825"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_165498627.1"
                     /transl_table=11
                     /translation="MSLGQIFAQRVRWHRTRQGKSQAVVAGLAGLNAEYLGQIERGYRI
                     PSLDVVEAIAGALGVSVPELVAESSERPSPAPDVLLASELHRALLLQQEASSGRSTDEL
                     QEAVEHAWRLWQGAADRYSRLAAVVPDLIGDVATINAPGATDPLLEHRVATDAYALLRT
                     VARRIGRPDLALVAADRERRAAEQTEDDVRLARANWNLAHALLGQQEPQTAEEIALAAI
                     ADIKGHGTREAAAISGALWLAAAVAAARSQRRFAAIERIRDHARPLAEKTGETNVGRTA
                     FGPTNVALHMVSVELEDGHTADALAIADEIDPAPLQSRERRTTLALDLARSHAMRSEPG
                     AALLHLLEAEQSSAEELRYNPTAHDTVRRVFQRARPSLRKQLTAFAQRVGIEDELAAGH
                     TLS"
     misc_feature    1617..1619
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2481..3068
                     /locus_tag="EKD16_RS21340"
                     /old_locus_tag="EKD16_21830"
     CDS             2481..3068
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKD16_RS21340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKD16_21830"
                     /product="hypothetical protein"
                     /protein_id="WP_131100783.1"
                     /transl_table=11
                     /translation="MSRADDNAAGALARLRWHYPHWDIRYYAATSLPERGVFVASIAPA
                     PEFLRGVLTAAAASEEGLLRQLEIHDPVASRIAEAAGTGTRDLPAGEEAVARLQGQHPR
                     WRIRYETGPGGGRFVATRPRTAEQAALGLLETVTAANALELAHRLAYQDALTAGAEAIA
                     QDIDIDPEDLIEGAADLVAGCEELLRRAAGSF"
     gene            3146..4483
                     /locus_tag="EKD16_RS21345"
                     /old_locus_tag="EKD16_21835"
     CDS             3146..4483
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKD16_RS21345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKD16_21835"
                     /product="cytochrome P450"
                     /protein_id="WP_131100785.1"
                     /transl_table=11
                     /translation="MPPVPEPPPPLLRLDDPVLDLPTALDRLDEEHFQRGLVPVELEKG
                     VPAWLMISLPVLHRVLKDEHYFARDPRAWRDLWNGTIPDTSPLQALYPPRRNALSVDGG
                     EHQRLRTALTGALQEVSLALLPARIREIADVVIDGFCTRGRADVVSEYASVLPLLVLCR
                     LFGMDQPAGLRVGMAMQRLWDGEADAGHAHHQLQDLLLEHAAYRRAHPGRDITSGMVAR
                     GLDDEEIRDQLALIMAAAHDPIAHALANTLADLLQTSRMHMVGSTWLISETLNHGVWRH
                     PPLETLVGRFPTADGLEVGGYRLARGDCLVMGFGAAQRHQLRTAPPEPSNRAYPVFGMG
                     PHGCPQLGRDIALAIAQTGVERLQQRLPDLRLSETDTPRRASTVIAGRRALPVTFTPAR
                     PITPAAPHQEEKWNPTRPAPASVSNSRTPPPTRSVFARLARWLRSS"
     gene            4465..5586
                     /locus_tag="EKD16_RS21350"
                     /old_locus_tag="EKD16_21840"
     CDS             4465..5586
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.5"
                     /locus_tag="EKD16_RS21350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21840"
                     /product="cytochrome P450"
                     /protein_id="WP_131100787.1"
                     /sec_met_domain="p450 (E-value: 2.8e-16, bitscore: 57.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVELAGLHLWAACGDEALRTVQGDISGTFLRGAENWPALQRGE
                     IDRTHPLVALVGDLRSLLALNGTEHEQIRRLLRPAFTPAAVKHRRPQIEAITDRLLDEM
                     EAAGPRADLLDFAWQLTVEVFLDLFGLGPEHAEKLTDITTRAFALSDPGVHAEARAYIA
                     DLLDHTPPDTAGGELLSLLATSQRDGDVSRADAIDTCYLLIVAGFDTTLGALLNAAHAL
                     AAHSDQRDLVQSGEVSWSEAVEECLRRYSSVATLPIVFTTREVELCGTELPAGAGVLLG
                     ISAAGLDPHRWHDPEVFDVTRNPKGHLAFGHGIHYCLGAHLARLELETALSRLFTRFPH
                     LDVAGPVPPLPSFMIRRPAGLPVNLNPGTARAA"
     gene            5721..6551
                     /locus_tag="EKD16_RS21355"
                     /old_locus_tag="EKD16_21845"
     CDS             5721..6551
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888772.1"
                     /locus_tag="EKD16_RS21355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21845"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_131100789.1"
                     /transl_table=11
                     /translation="MSDHTPAPPTGVDPYTPSAARLYDFYLGGKDNYAADRDAGTELLE
                     RIPELHSTAHANRYFLRRVVRHLAAEAGIRQFLDIGSGLPTQDNVHQVAQRHAPGARVV
                     YVDNDPIVLAHAHALLAEDPATTAVAEADLRDPAGILAHPRIRGMIDFTRPVAVLMIAV
                     LHFLTDDDRPYEVVAALRDRLCPGSYIAVSHLENETSPQRAAFMEQVYARSSATLKGRS
                     HAEIRRFFTGLELVEPGVVPISQWRRDPDEPYWPPEQAWGDGGLGRLTQRPPAG"
     gene            6817..8739
                     /locus_tag="EKD16_RS21360"
                     /old_locus_tag="EKD16_21850"
     CDS             6817..8739
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017620956.1"
                     /locus_tag="EKD16_RS21360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21850"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_242677103.1"
                     /transl_table=11
                     /translation="MNRRRPAPATPAGLPELATSRFHPWFGDLQRLSLWRMLTRLPALI
                     ATALRWSWKASPRDTLLTVGLNIAAGALSAIVLTAVVGILQGLFAQGPTPERLQAALPS
                     LLLAGAAMVTRAALRSAAIWAQGRLTPMVERAVEVELVSLTTATRLEAFDDSDWCDQIH
                     RARTLGVYEAGRITGYAADIATELISLLAVATVVTVLHPVLLPLLALTVAPVGWAAIRS
                     ARMRYARMRALSTSNRLLYMYTHAMTEREAAAELRAYAMRPMLLAEFARISDHVRDALL
                     AVVGRQTTTRAVGDVLGGIATLATYAALVALLLAGLMPLAVAGAAYLALGQGKAALDRL
                     MNAVNSCYESGLYLSDLLEAFDQARRRTPPAAGTTSPGPLEELRVQGVDFAYPAAEANA
                     LTGVSITVERGRIVALVGENGSGKSTLATLISGLYVPDAGTITWNGTDIADLDPDELHA
                     RIGLIRQQYHQWPFSAERNITMAAPGTADPDRLGRALRLSGADQVVADLAHGLDTPLDT
                     RFKDGADLSGGQRQRIAAARGLYPQADLVIADEPTAALDARAEERLFSTFQAAADGAAV
                     LLITHRLASTRSADWIYVLDHGHVVEQGTHTDLITHGGLYAELYGIQAAAYNGATPHRH
                     TEEFL"
     gene            8932..9351
                     /locus_tag="EKD16_RS21365"
                     /old_locus_tag="EKD16_21855"
     CDS             8932..9351
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKD16_RS21365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKD16_21855"
                     /product="hypothetical protein"
                     /protein_id="WP_131100791.1"
                     /transl_table=11
                     /translation="MEANHRLRGAREACTSPAAPDRPMSRAELAEAVNDYLWRTEGKAY
                     ALDGHTIARYERGRVRWPNANYRAGLRAILRVADDAGLGFHPTPRGSSAPPAPDRERSE
                     AMGTEEFSPSRSSYPRSGFGGSAKTAPAAPIPAAH"
     gene            9692..9877
                     /locus_tag="EKD16_RS21370"
                     /old_locus_tag="EKD16_21860"
     CDS             9692..9877
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573280.1"
                     /locus_tag="EKD16_RS21370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21860"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_131100792.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 6.8e-16, bitscore:
                     56.1, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTIDQPAELQQITDPGNETDPFGLDITFIENTPATETELLCS
                     TGDNCGSSCPSACTTS"
     CDS_motif       9692..9808
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MSTSTIDQPAELQQITDPGNETDPFGLDITFIENTPATE"
                     /locus_tag="EKD16_RS21370_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9809..9877
                     /prepeptide="core"
                     /locus_tag="EKD16_RS21370_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-6.20"
                     /molecular_weight="1991.1"
                     /monoisotopic_mass="1989.8"
                     /core_sequence="TELLCSTGDNCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSTSTIDQPAELQQITDPGNETDPFGLDITFIENTPATE"
                     /leader_location="[9691:9808](+)"
                     /alternative_weights="2009.1"
                     /alternative_weights="2027.2"
                     /alternative_weights="2045.2"
                     /alternative_weights="2063.2"
                     /alternative_weights="2081.2"
     gene            10001..11992
                     /locus_tag="EKD16_RS21375"
                     /old_locus_tag="EKD16_21865"
     CDS             10001..11992
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629316.1"
                     /locus_tag="EKD16_RS21375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21865"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_242677104.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.2e-18,
                     bitscore: 65.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.3e-104,
                     bitscore: 347.1, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLRAAANLTGPDMPPWPEPTAAVERWRSWLAAVWVDDAFRHAVST
                     ASPDLARRVQSVLDGRSPKPRRVRRAALATARYAIRYTQRSTPFGLFAGVAPVTFDDAA
                     EAHVGRQHLAAGRPDPVALEKMISAWETDAARMAEVDVCVNNLARRRGDRIYIPGEGPS
                     EVSLALTPAVELVLEAARSPIRFSALADKLAAEFTDKAEAHWAGMLTQLLRVRLLRSAL
                     RAPATVVDPADHLPSALREEAEDSPAAPDLRLDATVQLPTAVVTEAETAATVLTRLAAY
                     PTGTPAWQRYAENFADRYGEGAEVPLELVTDPEEGLGLPEGFGEISQAPRPMTLRDRLL
                     LELATTAAVEGRREVVLSEPVIERLEAAAGTRALTPPHLELCAQVQADSMRAVDRGNFR
                     LRVSTVSRAVGSMTGRFWHLFSHTGSGCASLPAVEPGAESAQLSFHSARTSGDLLTRAP
                     QVLPRLVSVGEFRYPTPGVLFPSDLAVGLREGRLYLAQAATGTRLELLAPTAINFQWNN
                     YTPALVRFVAEISRAGVPQVTWFDWGAAWTLPFTPALHYRRSVLVPARWKLHARDLPGR
                     GATPRQWADGLHEWMRRFRVPDRVVLVEDDQHLPLDLRHDLHRDLLRNHLGASRTGVAV
                     VQEAPPPDADGWLGGRANSVVIPLEARP"
     aSDomain        10424..10675
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EKD16_RS21375_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="7.00E-21"
                     /identifier="RREFam001.1"
                     /label="EKD16_RS21375"
                     /locus_tag="EKD16_RS21375"
                     /protein_end="225"
                     /protein_start="141"
                     /score="65.7"
                     /tool="antismash"
                     /translation="VCVNNLARRRGDRIYIPGEGPSEVSLALTPAVELVLEAARSPIRF
                     SALADKLAAEFTDKAEAHWAGMLTQLLRVRLLRSALRAP"
     misc_feature    11093..11095
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11989..13059
                     /locus_tag="EKD16_RS21380"
                     /old_locus_tag="EKD16_21870"
     CDS             11989..13059
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629315.1"
                     /locus_tag="EKD16_RS21380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21870"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_131100794.1"
                     /sec_met_domain="LANC_like (E-value: 7.3e-32, bitscore:
                     108.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPTLPRTQDLSDGALGTALLHVERGDTASARSTLAQAVADGIS
                     TGGNASLFHGAPALEFVLLRAGITRRDVCAAVDRVVAARLTAARRRQESGVLPHVAEFD
                     LIRGLTGLGALLLARSEAAPLLKDVLVYLVSLSRPVRTEEREMPGWWSDVGPSGEELDG
                     GHGNNGVAHGIAGPLALLSLAARHGVQVPDQREAIAVFDHWLDTHGCNYWTSDDQLRAP
                     GPPTPVPTRPSWCYGRAGTARAQHLAAIALGDPSRRRAAENQVIQTLTDAVWLDRITDA
                     TLCHGWAGLLTVVRAVAEDSPAAARFTPLIADLHRRLAADRERLPERGLMEGRVGAQLP
                     VEATDATGWARLLLIT"
     gene            13112..15163
                     /gene="fxlM"
                     /locus_tag="EKD16_RS21385"
                     /old_locus_tag="EKD16_21875"
     CDS             13112..15163
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629314.1"
                     /locus_tag="EKD16_RS21385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21875"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_131100796.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.7e-18, bitscore:
                     65.4, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 7.9e-43, bitscore: 144.8,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDEDERLPGAAEEGWWSASVWFAGEAGVSSHAAQALCSTLADQR
                     FHFVRKDGGLRLRTQHCAAHHLDALVADQVATRWVGTVYEPETEAFGGSAGMAIAHALF
                     CADSPSALMETGAPGARERCVLLLSVLLRHAGLDPFEVGDVWTKLGALRPPLTPPAGSA
                     RDSAVAAMRRLMNADAQHRPNAEADWAERVTAFTDAGRRLRSLADQGRLTRGLRAVLAH
                     HAVFAFNRAGVPIDQQAATAWLGSHVAFADRQDADVSTHLSAHSTTDATRMETMTSATD
                     PADLRDELVNRLVGSGHLRTPEAIAAFREVQRDRFLPGVDQHAAYAEDAVSIKHDDTGD
                     MISCISAPSIVATQLEQLGARPGHRVLEAGAATGYNAALLGRLVAPGGHVWTVDVDQDL
                     VEGARKNLAEAGASNVTAVLGDGAAGWPDHAPYDRIQFTVGAGDVPARILDQLAPHGRL
                     VLPMRIRGSISRSFAFERDGDAWKTVSCEMATFIPLRKGVCDDVYTRVPMAGEGNVLLE
                     TFSEQDVDREAIRTVLDQQQAKVYSGVKFRQGDPWEWLYLYLAAVLPNGLSRMPGARPG
                     FTPHFGWGSMAALDGGSLAYLTVREGEDAQGRFWEIGVIGHGPCADELAEQVAGEIVAW
                     DEGWGNTAPSPTFRMALGEARDRLKTNDPRFVIDKPHSRLVIDWPRRS"
     gene            15168..16268
                     /locus_tag="EKD16_RS21390"
                     /old_locus_tag="EKD16_21880"
     CDS             15168..16268
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019629313.1"
                     /locus_tag="EKD16_RS21390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21880"
                     /product="hypothetical protein"
                     /protein_id="WP_131100798.1"
                     /transl_table=11
                     /translation="MIPPIATRIPLVRRPKAPALPLEQRIAHVTGLADESAGASHHDLV
                     ARASGVLNYAALIASDAALPDLAADLCWKQHRAFADAGRLTGEIAVMALMPLINLSRLL
                     TREGDGEGAYDVLKQLYRTAHARSSTHIRGHDVDLSALTATESDHHDVCKALWVALLVD
                     GARALARIGCWTQAAEAMTAHRGVGHRLLDGRQIMIMSLMERGLYQQARDAIEATAPTE
                     EWENAIAALLQVACRPATAPASAQERDEALLGAGAVLTSPDPATALFQTRVGLAALELT
                     HHHTGPHTAGLHDPIVDAARLDAYAARDTLTHPLVGAHLDEEQRSHLESIVAESGLGAG
                     RLSPTHMETLTAASERAEAALRRLLA"
     misc_feature    15231..15233
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16041..16043
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16779..17855
                     /locus_tag="EKD16_RS21395"
                     /old_locus_tag="EKD16_21885"
     CDS             16779..17855
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="EKD16_RS21395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21885"
                     /product="phosphotransferase enzyme family protein"
                     /protein_id="WP_131100800.1"
                     /sec_met_domain="APH (E-value: 2.9e-23, bitscore: 81.2,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNSAGLSATVARVLDERYGLAPAQLSPVRGGQHTVNLRADSGKR
                     AMFVKTYEDSADLATERRAIALSEFAGENGVPVSPVIDNREGDPIDTSSPVAMSVWEWM
                     PGSAAQELNPSIAEQAGRALGHLHRATADLTESRRPAGPVQDAWRGIDTDGISATIDHL
                     LGIIEERVHAGQAGPFDTLAARTLTERRAMLPALPSLAAELPGDLTVQVLHGDYAPRNL
                     LFDDEGRLTAVLDFSPPTPGLLAYDIGRAALFATTLARGDWLDCANALLTAYLDVNPTV
                     TASDLQACYHVPVIQLLRSLYGIKQHYLSPGIDQADLDDFWHMRHRAAQTLLEHRGSIE
                     DMLTKLAHHLPPTRPSRC"
     gene            18705..18950
                     /locus_tag="EKD16_RS21405"
     CDS             18705..18950
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040183.4"
                     /locus_tag="EKD16_RS21405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Scr1 family TA system antitoxin-like
                     transcriptional regulator"
                     /protein_id="WP_242677479.1"
                     /transl_table=11
                     /translation="MRKQGEYLLRVGQLPHIDLQVLPFSVGAHAALGSAFTVLDFLGAV
                     DPTIIFTDSIGGGLFEESPEEVDQYVAIFGDVQGSA"
     misc_feature    18828..18830
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            19012..19206
                     /locus_tag="EKD16_RS21410"
                     /old_locus_tag="EKD16_21895"
     CDS             19012..19206
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541303.1"
                     /locus_tag="EKD16_RS21410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21895"
                     /product="DUF397 domain-containing protein"
                     /protein_id="WP_131100804.1"
                     /transl_table=11
                     /translation="MSHPTPEFRKSSYSTRNSQNCVEVADLDGGAGAVRDSQHPDHGRL
                     EFTSAEWRAFLAHVKSDQV"
     misc_feature    19215..19229
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            19556..20197
                     /locus_tag="EKD16_RS21415"
                     /old_locus_tag="EKD16_21900"
     CDS             19556..20197
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009086176.1"
                     /locus_tag="EKD16_RS21415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21900"
                     /product="HAD family hydrolase"
                     /protein_id="WP_131100806.1"
                     /sec_met_domain="HAD_2 (E-value: 4.2e-11, bitscore: 41.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRSVVFDVGETLLDDTREWARWADWIQVPRHTFSAVLGAVTAQG
                     RDNSETFTYFKPDFDLARERQAREEADQGEHIEETDLYSDVRPTLQALRDQGAWLGIAG
                     NQTRRAAELLRQLDLPVDLIATSGEWGVAKPAHGFFEHVKYMASGTAREIVYVGDHRDN
                     DVLPAAAAGLNSALIRRGPWGYLWASDSRVTTHATWVIDSLAELPDLLRP"
     gene            complement(20353..21243)
                     /locus_tag="EKD16_RS21420"
                     /old_locus_tag="EKD16_21905"
     CDS             complement(20353..21243)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013775.5"
                     /locus_tag="EKD16_RS21420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21905"
                     /product="phosphotransferase family protein"
                     /protein_id="WP_131100807.1"
                     /sec_met_domain="APH (E-value: 6.5e-17, bitscore: 60.4,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSHVLDTSAVLTAAARAAGIKADGAELIRDGANVLYRLPDRVVA
                     RVGRPGTCAVAEREVDVSRWLEGCAVPVVHALTGVPQPTVIDGSPVTWWRLLPPHRPAT
                     PGELGAVLGTIHRLPIPEELRLPRFDPFAGIDPDHISTAQALDPEDRAWLTRRLADLRE
                     QHLKLGAVGGCGVVHGDAWQGNVAVPEEGPPIVLDLEKVALGPRDADLVSLAVDHTDFA
                     RISDEDYNAFVTAYGGYDVTTAPGFGTLAEIQELRWVCFTLSKAATRPGAAEEARHRIR
                     CLRGDIPRPWTWRAF"
     gene            complement(21294..21563)
                     /locus_tag="EKD16_RS21425"
                     /old_locus_tag="EKD16_21910"
     CDS             complement(21294..21563)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKD16_RS21425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKD16_21910"
                     /product="hypothetical protein"
                     /protein_id="WP_207391367.1"
                     /transl_table=11
                     /translation="MESPEWMELFVSCSLPSGLIRMLFPQTAKGTVLTEDPYPSSTAAV
                     DKGAVTYLARRLLNEKTAEDEKLWEFGVIGHGPGSAPCWRTSPT"
     gene            22106..22873
                     /locus_tag="EKD16_RS21435"
                     /old_locus_tag="EKD16_21915"
     CDS             22106..22873
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010399294.1"
                     /locus_tag="EKD16_RS21435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21915"
                     /product="NYN domain-containing protein"
                     /protein_id="WP_131100809.1"
                     /transl_table=11
                     /translation="MDNESTARLAVLIDADNAQPSIAVNLLAEVAQYGTAHVKRAYGDW
                     TGTSLKGWKEQLLTQSIQPMQQFAYSTGKNATDAALVIDAMDLLYTDRFDGFCIVSSDS
                     DFTRLAARIRESGLTVYGFGERKTPKPFVSACDKFIYTENLVSTQKTPAETEQPLQQGQ
                     ANGASVLPASDAGLASLLREVVAAASNDDGWAHLAAVGSIARKRQPDFDPRSYGHAKLM
                     SLIEATGLFNLAKRDPGGGNPPVVYVRDRSRAS"
     gene            complement(22984..23847)
                     /locus_tag="EKD16_RS21440"
                     /old_locus_tag="EKD16_21920"
     CDS             complement(22984..23847)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.5"
                     /locus_tag="EKD16_RS21440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21920"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_131100811.1"
                     /transl_table=11
                     /translation="MCDRMFENLASEEARSAAVLAAHVLLFDRGRVLLTRRSANAAYAP
                     LYWHASVAGKVEPHESVVDAAVREAREELGIVLAPGDLEPAHVMHSAENGSRLHVFFAA
                     RTWEGVPVNAEPDKHAQIAWNPAHRLPDATVGYCAQAIEAYLTGAPFSLHRFPHNGETA
                     AASGPAAEADLGDAGVPGSLELMFNRIAAERRRQERMYGIQNLSSGNGPQHRPQAERAQ
                     SNVDDAGHPPTFYDLAFEELSEARAADDRELLEELVQSAAVLVQWGQAVLASQEAGDPT
                     TPSSRS"
     misc_feature    complement(23828..23843)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.61"
                     /tool="antismash"
     misc_feature    23829..23842
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 21.32"
                     /tool="antismash"
     gene            24338..25141
                     /locus_tag="EKD16_RS21445"
                     /old_locus_tag="EKD16_21925"
     CDS             24338..25141
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.5"
                     /locus_tag="EKD16_RS21445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_21925"
                     /product="trans-aconitate 2-methyltransferase"
                     /protein_id="WP_131100813.1"
                     /transl_table=11
                     /translation="MSHFTGTATYYRRYRPGIPDDVTSVLDHAAPTRSKGRRRLLDVGT
                     GTGLVAEALLDRFDDIIGVDSDADMLAAAESALRPKLPEHSRLSLVQSTAEDFTPPTGW
                     QAELVTICRAFHWLDQGTVLSLLDEQVAPDGVVAIFSDSSFWTASSPWKEAVRDVVKSC
                     LGEERRAGAGTFQHHNRPYSDLLAESPFDAVEEVRVPVECTWTAESILGYLYSTSFAAP
                     HLFGDRVKEFEAAVKHRLAEFSGDDTFPEENEFLIRLGRRSRNGG"
     misc_feature    24599..24601
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 taccagccgg aggcgggcgt tctggagttc tcggttcggg agtggacagc gttcctcgcc
       61 tcggctcggc gcgaggatct gtagggctgc tcggcctgct cccccaggtg tgtggcgcct
      121 tcagccatgc ctgctcactc caccgctatg agggactcac tctccagcac gaacagtgag
      181 aacacggcca acaaggtcac ggatatcgac cgactccaac gtgcccagga ccaggtccgc
      241 tcccacttcc gtcagctcat cgacggagct ggttccagag gcgactgcga tgacgcccac
      301 tccggcctct cgcgccgctg cgatgtcctt gggggtgtct ccgataagga cggccctctc
      361 cctcggcacc ggcatgcccc ctcgttccgc agctcgggcg agagcgacct cgaccagccg
      421 cggccggtag gagtcgtcgt caccgtaggc tcctactgcc aggtccaaat ggcgatccaa
      481 gccgaacgcg ctcagcttga cctgcgccgc tcgtcttgtg ttgcccgtca gcgcactctg
      541 catcacgccg ggttccgtcg ccagggcacc aagggcctcc tcgacgccgg gcaggacgcg
      601 cccccgctcc cggagttcat ccgaacgggc gcggtacccg tccgcctgtg cggcggcgaa
      661 acgctcgaac agcccttcct cgcggtcctt gatcccattg agctccaggg tcttctccaa
      721 tagcaccggt tccgtgtgcc cgtgggccgt ggccatgccg gcgctcatcg tggctccggt
      781 ggccttctcg aacgcttccc ggaacacagt gctgcccaca ccgcgggtct cgatcaacgt
      841 gtggtcgacg tcccagagga cgaggcagcg gggcagcatc ggcggctcca acaaggggaa
      901 tcgggcgcgg gccatttacc atgtaccccc acggacgctg ttccagccag gagggcggga
      961 tcatgtcgct gggtcagatc ttcgcgcaac gtgtgcggtg gcatcgcact cggcagggta
     1021 aatcccaggc agtggtagca ggactcgcgg gccttaacgc cgagtacctc ggacagatcg
     1081 agcgtggata ccggatcccg tcattggatg tcgtcgaggc tatcgccgga gctctcgggg
     1141 tttccgtgcc cgaactggta gccgagagca gtgagcgccc ctcacccgct cccgacgttc
     1201 tattggcgtc tgaactgcac cgcgctcttc tcctccagca ggaagcctcc tctggccgca
     1261 gtaccgacga gctacaggaa gcggtcgaac acgcctggcg cctctggcaa ggggccgcgg
     1321 accgctacag ccgtctggcc gctgtggtcc ccgacctgat cggtgacgtc gctacaatca
     1381 acgcccccgg agcaaccgat cccctccttg agcaccgagt ggcaaccgac gcctatgctc
     1441 tcttgcggac tgtggctcgg cgcatcgggc gccccgacct ggcgttggtc gcggccgatc
     1501 gtgagcgtcg ggccgccgaa cagacagagg acgatgtccg cctggcacgg gcgaattgga
     1561 acctcgcaca cgcgttgctg gggcagcagg agccccaaac agccgaggaa atcgccttag
     1621 cggccatcgc cgatatcaaa gggcatggaa cccgcgaagc cgcagcgatc agcggcgcgc
     1681 tgtggctggc cgccgctgtg gccgccgcgc gtagtcaacg aagattcgcg gccatcgagc
     1741 gcatcaggga ccatgctcgc cccctcgcgg aaaaaaccgg ggaaaccaat gtggggcgaa
     1801 ccgccttcgg accgaccaac gtcgccctac acatggtcag tgtcgaactc gaggacggcc
     1861 acaccgccga cgccctggct atcgccgacg aaatcgatcc ggctccgctc caatcacgtg
     1921 agcgccgcac aactctcgcg ctcgacctcg cccgcagtca cgcaatgcgg tccgagccag
     1981 gggctgcgct gctgcatctg ctagaagccg agcagagcag cgctgaggaa cttcgctaca
     2041 acccgacggc gcacgacacc gtgcgccggg tattccagcg cgcccgtccg tcgcttcgca
     2101 agcagctcac cgctttcgcc cagcgtgtcg gcatcgaaga cgaactcgcc gccggtcaca
     2161 cgctttccta gctctgcgct aggacgtcgc aacgctagta ggcctggtta cacccttccg
     2221 taggttcgtc ctcgctgcat gatccaccac gctgcgagga gacaaggaat ggccgactgc
     2281 cgaacgcctt tggcgacatg cgcgtccgca gtggcgcggg cgcaccgatg ccaccggcca
     2341 gtgtccgtcg atggacacag catattcggg caaggaccgg acttcgctat ccgcaagacc
     2401 ttcgggacaa caccggccgt tcgccaatac gtcgtgtggt cgggcagcga atgcgcaccg
     2461 gccaatgagg caggtgcgtc gtgagcagag ctgacgacaa tgccgctggc gccctggccc
     2521 gtctgcgctg gcattatccc cactgggaca tccggtatta cgccgccacc tcgctgcccg
     2581 aacgcggcgt gttcgtggcc agcatcgcac cggctcccga gttccttaga ggagttctaa
     2641 ccgcagcggc tgccagcgag gaagggctcc ttcggcagtt ggagatccat gaccccgtgg
     2701 cgagccgcat cgcagaggcc gccggcacgg gcacgcggga tctccctgca ggcgaagaag
     2761 ctgtagctcg gcttcagggg cagcatcccc ggtggcggat ccgctacgag accggccccg
     2821 gcggcggccg gttcgtggcc acacggccac gaacggctga gcaggccgcg ctcgggctgc
     2881 tggagaccgt gaccgccgcc aacgccctgg agctggcgca ccgcctggcc taccaggacg
     2941 ccctgaccgc cggcgcggaa gcgatcgccc aggacatcga tatcgatccc gaagacctga
     3001 tcgagggcgc cgccgacctg gtcgccggct gcgaggaact tctgcgccgt gccgccggaa
     3061 gcttctgacg caacgccacc ggtgcactcg gaccggaccg ggttcccgct cgaccgcccc
     3121 tccctcgtgt gaaagcgaca ccgccatgcc accggtcccc gaacccccac cgccgctgct
     3181 gcggctggat gatcccgtcc tggacctgcc caccgccctc gaccgcctcg acgaggagca
     3241 cttccagcgc gggctggtgc ccgtcgagct ggagaagggc gtgcccgcct ggctcatgat
     3301 cagcctgccc gtgctgcacc gggtcctcaa agacgagcac tacttcgcgc gagatccccg
     3361 cgcttggcgc gacctgtgga acggcaccat ccccgacacc agcccgctgc aggcgctgta
     3421 tccgcctcgc aggaacgcct tgtcggtcga cggcggcgag caccagcggc tgcgtacggc
     3481 gctgaccgga gccttgcagg aggtgtccct ggcgctgctg cccgcccgca tccgcgagat
     3541 cgccgacgtg gtcatcgacg ggttctgcac ccggggccgg gccgacgtgg tctccgaata
     3601 cgcctccgtg ctgccgctgc tggtgctgtg ccgcttgttc ggcatggacc agcccgcggg
     3661 gctgcgggtg ggtatggcca tgcagcgcct ctgggacggc gaggccgacg ccggccacgc
     3721 ccaccaccag ctccaagacc tgctgctgga gcacgccgcc taccgccgcg cccacccggg
     3781 ccgcgacatc accagcggga tggtcgcccg cgggctggac gatgaggaga tccgcgacca
     3841 gctcgcgctg atcatggccg ccgcacacga ccccatcgcc cacgcactcg ccaacacgct
     3901 ggccgacctg ttgcagacgt cgcggatgca catggtcggc tccacctggc tgatcagcga
     3961 gaccctcaac cacggggtgt ggcgccaccc gcccttggag accctggtgg gccgcttccc
     4021 caccgccgac gggctcgagg tgggcggcta ccggctggcg cgcggcgact gcctggtcat
     4081 gggcttcggc gccgcccagc ggcaccagct gcgcaccgcc ccgcccgaac cctccaaccg
     4141 ggcctatccg gtgttcggca tgggcccgca cgggtgcccg cagctgggcc gcgacatcgc
     4201 cctggccatc gcccagaccg gggtggagcg cctccagcag cgcctgcccg acctgcgcct
     4261 gagcgagacc gatactccgc ggcgcgcctc gacggtcatc gccggacgcc gcgctcttcc
     4321 cgtcacgttc acccccgccc gcccgatcac acccgccgca ccacaccagg aggagaagtg
     4381 gaatcccact cgccccgcac ccgcatccgt ctcgaactcg aggaccccgc caccaacacg
     4441 cagcgtcttc gcgaggctgg cccggtggct gcggtcgagc tagccggcct gcacctgtgg
     4501 gccgcctgcg gcgacgaggc cctgcgcacc gtccaaggcg atatctccgg cacgttcctg
     4561 cgcggcgccg agaactggcc cgccctgcaa cgcggggaga tcgaccggac ccatccgctg
     4621 gtggcgctgg tgggcgacct gcgcagcctg ctcgccctca acggcaccga acacgaacag
     4681 atccggcggc tgctgcggcc cgccttcacc ccggccgccg tgaaacaccg ccgcccccag
     4741 atcgaggcca tcaccgaccg cctcctggac gaaatggaag ccgccgggcc gcgggcggac
     4801 ctgctggact tcgcctggca gctgaccgtg gaggtgtttc tcgacctgtt cgggctgggc
     4861 cccgagcacg ccgagaagct caccgacatc accacccgcg ccttcgccct ctccgacccc
     4921 ggcgtgcacg cggaggcccg cgcctacatc gccgacctgc tcgaccacac cccacccgac
     4981 accgccggcg gcgaactgct ctccttgctg gccacatccc agcgcgacgg tgacgtgtcg
     5041 cgcgccgacg cgatcgacac ctgctacctg ctgatcgtcg cgggtttcga caccaccctc
     5101 ggggccctgc tgaacgccgc ccacgccctg gccgcccact ccgaccagcg cgacctcgtc
     5161 cagtcgggag aggtgagctg gtcggaggcg gtcgaggagt gcctgcgccg ctacagctcc
     5221 gtggccaccc tcccgatcgt cttcaccacc cgcgaggtcg agctgtgcgg caccgaactg
     5281 cccgccgggg ccggggtgct gctgggtatt tccgccgccg ggctcgaccc ccaccggtgg
     5341 cacgaccccg aggtcttcga cgtcacacgc aaccccaagg ggcatctggc cttcgggcac
     5401 ggcatccact actgcctggg cgcccacctc gcccgcctgg aactggaaac ggctctctcg
     5461 cgcttgttca cccgcttccc ccacctggac gtggcgggtc cggtgccgcc gctgcccagc
     5521 ttcatgatcc gccgccccgc cggcctgccg gtgaacctga accccggcac tgcccgcgcc
     5581 gcctgatcgg cgacttctct cggtggccgc atcctccggc gaccagcacg agcgcaggca
     5641 agacgccaac accgccttcg gccccaccgg cgtgctctcc gaagctgcaa accacctctg
     5701 tgtatgacag gtgcatcacc atgtccgacc acacacccgc tcccccgacc ggcgtcgacc
     5761 cttacacccc cagcgccgcc cgactctatg atttttattt gggcggcaag gacaactacg
     5821 ccgccgaccg cgacgccggc accgagctcc tggaacgcat ccccgagctg cacagcaccg
     5881 cccacgccaa ccggtacttc ctgcgccgcg tcgtgcgcca cctggccgcc gaagccggga
     5941 ttcgccagtt cctggacatc ggctccgggc tgcccaccca ggacaacgtc caccaggtcg
     6001 cccagcgcca cgcccccgga gcccgcgtcg tctacgtcga caacgacccc atcgtgctcg
     6061 cccacgccca cgcgctcctg gccgaggacc ccgccaccac cgcggtcgcc gaagccgacc
     6121 tacgtgaccc cgccggaatc ctcgcccacc cccggatccg ggggatgatc gacttcaccc
     6181 ggccggtcgc cgtgctgatg atcgccgtcc tgcacttcct caccgacgac gaccgcccct
     6241 acgaggtggt ggccgcgctg cgcgaccgac tgtgcccggg ctcctacatc gccgtctccc
     6301 acctggaaaa cgagaccagc ccccagcggg cggcattcat ggaacaggtc tacgcccgca
     6361 gctccgccac cttgaaaggg cgcagccacg ccgagatccg ccggttcttc accggtctgg
     6421 aactcgtgga gcccggtgtg gtgcccatct cccagtggcg ccgcgacccg gacgagccct
     6481 attggccgcc cgagcaggcc tggggcgacg gcggcctcgg ccgccttacc caacggccgc
     6541 ccgcgggctg agggggacac ggctctgtct cgcaccggcc gaggggtggc ccgcttcccg
     6601 cgcgggctta ccgaggcgtc gggctccctg gccgagccga cacacaacac caaccactac
     6661 gggcccacca cccggggcag ggactgggtg gaccaggcgc caccccgccc accctgcacc
     6721 ggcgcacccc gcgccggcgc accggcccgc cccggagccc ggccctcggt cctccttgtg
     6781 tccgccgctt cccgcaccga cgtgtaacgg agttgtatga accggcgccg ccccgccccg
     6841 gccacccccg caggactgcc cgaactggcc accagccgat tccacccctg gttcggcgac
     6901 ctgcagcgcc tatcgctgtg gcgcatgctc acccgcctgc ccgccctcat cgccaccgcc
     6961 ctgcgctgga gctggaaagc cagcccccgc gacaccctgc tcaccgtcgg cctcaacatc
     7021 gccgccggcg ccctctccgc gatcgtgctc accgccgtgg tcggcatcct gcaaggcctg
     7081 ttcgcccagg gccccacccc cgagcggctg caggccgccc tgccctcgct cctgctggcg
     7141 ggcgcggcca tggtgacccg ggccgcactg cgctccgcag cgatctgggc ccaaggccga
     7201 ctcaccccca tggtcgaacg ggccgtggag gtcgaactcg tctcactcac caccgccacc
     7261 cgcctggagg ccttcgacga ctccgactgg tgcgaccaga tccaccgcgc ccgcaccctg
     7321 ggcgtctacg aagccggacg catcaccggc tacgccgccg acatcgccac cgaactcatc
     7381 agcctgctgg ccgtggccac cgtcgtcacc gtcctgcacc ccgtgctgct gccgctgctg
     7441 gcgctgaccg tggccccggt cggctgggcc gcgatccgct cggcccggat gcgctacgcc
     7501 cgcatgcggg cgctgagcac ctccaaccgg ctgctgtaca tgtacaccca cgccatgacc
     7561 gagcgcgagg ccgccgccga gctgcgcgcc tacgcgatgc gccccatgct gctggccgaa
     7621 ttcgcccgca tctccgacca tgtgcgcgac gccctcctgg ccgtggttgg ccgtcagacc
     7681 accacccgcg ctgtgggcga cgtgctgggc ggcatcgcca ccctggcgac ctacgccgcc
     7741 ctggtcgcgc tgctgctggc cgggctgatg ccgctggcgg tggccggggc cgcctacctc
     7801 gccctgggcc agggcaaagc cgccctggat cggctcatga acgccgtcaa ctcctgctac
     7861 gaatccggcc tctacctgtc ggacctgctg gaggccttcg accaggcccg ccgccgcacc
     7921 ccgcccgccg ccggcaccac ctcccccgga ccactcgaag agctgcgggt gcagggtgtg
     7981 gacttcgcct accccgccgc cgaggccaac gcgctcaccg gagtcagcat caccgtcgaa
     8041 cgcggccgga tcgtggccct ggtcggcgag aacgggtccg gcaaatccac cctggccacc
     8101 ctcatctccg ggctgtatgt gcccgatgcc ggcaccatca cctggaacgg caccgacatc
     8161 gccgacctgg accccgacga gctgcacgcc cggatcgggc tgatccgcca gcagtaccac
     8221 cagtggccct tctccgccga acgcaacatc accatggccg cccccgggac cgccgacccc
     8281 gaccggctgg gccgggcgct gcggctcagc ggcgccgacc aggtggtcgc cgacctcgcc
     8341 cacgggctgg acacgccgct ggatacccgg ttcaaagacg gcgcggacct ctccggcggg
     8401 cagcgccagc gcatcgccgc cgcccgcggc ctctaccccc aggccgatct ggtcatcgcc
     8461 gacgagccca ccgccgccct ggacgcccgc gccgaggagc ggctgttctc cacattccag
     8521 gccgccgccg acggggccgc ggtgctgctg atcacccacc ggctggccag cacccgcagc
     8581 gccgactgga tctacgtcct cgaccacggc cacgtcgtcg aacagggcac ccacaccgac
     8641 ctgatcaccc acggcgggct ctacgccgag ctctacggca tccaagccgc cgcctacaac
     8701 ggagccaccc cgcaccggca caccgaagaa tttctatgac cagcaccgtc gcggacgtgg
     8761 ccgacccgtc tgctccgtgt tctggaagag gaatccacca atgcgatatc cacccggcag
     8821 tcacacgctc cccgggcacg cctcccctgc cgccgaccct gcaggcggtc ggcgggacgg
     8881 ttccctggcc ccgcagatgg cgatccggac cgtcggatgc agggagtgag tgtggaagcc
     8941 aaccaccggc ttcgtggagc gcgagaggcg tgtacatcgc cggcggctcc ggaccggccg
     9001 atgagccggg ccgaactggc cgaagcggtc aacgactacc tatggcgcac cgagggcaaa
     9061 gcctacgcgc tggatggcca caccatcgcc cgctacgaac gcggcagagt gcgctggccc
     9121 aacgcgaact atcgggccgg actccgcgcg atcttgcgcg tagccgacga cgcggggctg
     9181 ggtttccacc ccacaccgcg tggcagcagc gcgccgcccg cgccagatcg cgaacgctcc
     9241 gaggcgatgg gaaccgagga gttttcgcct tcgaggagca gctacccgcg ttccggtttc
     9301 ggcggctccg ccaagacggc gccagcggct ccgatcccgg cagcacactg acggcatcag
     9361 ggccatccgc ctgatggtcg aagcatccag tcgcccaggt caacgccggg gaacgcgtct
     9421 ggccgtcagc ggtctaccgc ggtcggtcgg agccgtggcg gtggcctcgg ccgtggggcg
     9481 ccgtggccgc tccagattgc ccttcggtgc accgcagaat gccctgccgt accccgcacg
     9541 ctcctggaaa agtgaccgtg tggcacccac ggagcgcact gtcacgagca ccgttcgtgc
     9601 cagtgcgcgt ggagccatac agcagagaaa caaccccgcg ggtcaccacc ttcgtcccgt
     9661 ggttccgcaa cagatgttgg gagtgcagtt gatgagcacg tcgaccattg atcagcccgc
     9721 cgagctgcag cagatcaccg atcccggcaa cgagacggat ccgttcggcc tcgacatcac
     9781 cttcatcgag aacacgccgg cgaccgagac ggaactgctg tgcagcaccg gcgacaactg
     9841 cgggagctcg tgcccgagcg cctgcaccac gtcgtaggac caggcagacg gtgcgggtca
     9901 cgtcggagcc gtccgactga cccgtcctgt tcgcacggag aacggagcga gggtgatgac
     9961 gcgctcacgg cgcagcctgt accggggggc cggtgaggga atgctgcgcg ccgcagcgaa
    10021 cctcaccgga cccgacatgc ctccatggcc agaacccacg gcggccgtgg aacgctggcg
    10081 ttcgtggttg gcagccgtgt gggtcgatga cgcctttcgt cacgccgtgt ccactgccag
    10141 cccggacttg gcacgccggg tccagtccgt cctcgacgga cgctcgccga agccgcgtcg
    10201 ggtacggcgg gcggcactgg ctacagcccg ctacgccatc aggtacacgc agcgatccac
    10261 gcccttcggc ttgttcgcag gcgtcgcacc ggtcactttc gacgacgcgg ccgaggcaca
    10321 cgtcgggcgt cagcacctgg ctgcgggcag gccggacccc gtcgcgctgg agaagatgat
    10381 cagcgcctgg gagaccgacg ccgcgcgcat ggccgaggtc gacgtatgcg tcaacaacct
    10441 ggcacgccgg cgaggcgacc gcatctacat tcccggcgaa gggccgtcgg aggtctcact
    10501 cgcgctgacg cctgcggtcg aactggtgct ggaggcggcg cggtcaccga tccggttttc
    10561 ggccctggcg gacaaacttg ccgccgagtt caccgacaaa gccgaggccc actgggccgg
    10621 catgctcacg cagctgttgc gggtacggct gcttcggtcg gccctgcggg cgcccgccac
    10681 cgtcgtcgat ccggctgacc acttgccctc ggctctgcgg gaggaggcgg aagacagccc
    10741 ggcggcgccg gacctgcggc tggacgcgac ggtgcagctt ccgacggcgg tcgtgacgga
    10801 ggcagagacc gccgcgaccg tcctcacccg cctcgctgcg tatccgacgg gtaccccggc
    10861 atggcagcgc tacgccgaaa atttcgccga tcgctacggt gagggcgccg aggtgccgct
    10921 ggagctcgtg acagacccag aggaagggct gggcttgccc gaggggttcg gcgagatctc
    10981 gcaggcgcct cggccgatga ccttgcgaga tcggctgctt ctggagctgg ccaccactgc
    11041 ggctgtggag ggccgccgag aggtggtcct gtccgagccg gtgatcgaac ggttagaggc
    11101 tgccgccggc acgcgggcgc tcactccgcc ccatcttgaa ctgtgcgccc aggtccaggc
    11161 cgactcgatg cgtgccgtgg accgaggcaa ctttcgcctg cgggtttcca ccgtctcccg
    11221 cgcggtcggc tcgatgacgg gccggttctg gcacctgttc tcccacaccg gttcgggatg
    11281 tgcgagcctg cccgcggtcg agcccggcgc ggaatcggct cagctgtcct tccattccgc
    11341 acgcacctca ggggacctgc tcacgcgggc cccgcaggtg ctgccccggt tggtcagcgt
    11401 cggagagttc cggtacccca cacccggagt actgtttccg tccgacctgg ccgtggggct
    11461 gcgcgagggc cgcctgtacc tcgcccaagc cgccaccggc acgcggctgg agctgctcgc
    11521 tcctacggcg atcaacttcc agtggaacaa ctacaccccc gctctggtcc ggttcgttgc
    11581 cgagatcagc cgggccgggg taccacaggt gacgtggttc gactggggag ccgcatggac
    11641 gctgcccttc acgcccgcgc tgcactaccg gcgatccgtc ctggtccccg cgcgatggaa
    11701 gctgcacgct cgcgatctgc ccggccgcgg cgcgacaccg cggcaatggg ccgacgggct
    11761 ccatgagtgg atgcgccggt tccgcgttcc cgaccgcgtg gtcctggtag aagacgatca
    11821 acaccttcct ctcgacctgc ggcacgacct gcaccgggat ctgttgcgca accatctcgg
    11881 cgcgagccgg accggcgtcg ccgtcgtgca ggaggcgccg ccgcccgatg ccgacggatg
    11941 gctgggcgga cgcgccaaca gcgtcgtcat ccccttggag gcgcgtccat gaccgcgccg
    12001 acgctaccca gaacccagga tctgtccgac ggcgcgctgg gcaccgcact cctgcacgtc
    12061 gaacgcgggg ataccgcatc ggcccgcagc acccttgcgc aggcggttgc ggacgggatc
    12121 agcaccggag gcaacgcgtc gctgttccac ggggccccgg cgctggaatt cgtcctgctc
    12181 cgggccggaa tcacgcgacg ggatgtgtgc gccgcggtcg accgcgttgt ggccgctcgc
    12241 ctcaccgcag cgcgtcggcg acaggaatcg ggggtgctgc cgcatgtggc ggaattcgac
    12301 ctcattcggg ggctgaccgg tcttggtgcg ctgctgttgg cccgaagtga ggccgcgccg
    12361 ttgttgaagg acgtcctggt ctacctggtc tcgctgtcgc gaccggtccg caccgaggaa
    12421 cgtgagatgc ccggctggtg gtcggatgtg ggcccttccg gtgaggagct cgacggcggc
    12481 cacggcaaca acggtgtcgc ccacggcatt gccgggcccc tggctctgct gtcactggcc
    12541 gcccggcacg gcgtccaggt accagaccag cgcgaggcca tcgcggtatt cgaccactgg
    12601 ctcgacaccc acggctgcaa ctactggacg agtgacgatc aattgcgggc gcccggtccg
    12661 cccacgccgg tgccgacgcg tccgtcctgg tgctacggac gcgccggcac cgcccgcgcc
    12721 cagcacctgg ccgcgatcgc cttgggcgat ccgtcccgcc gacgcgcggc cgagaaccag
    12781 gtcatacaga ccctgacgga tgcggtctgg ctcgaccgca tcaccgacgc cactctgtgc
    12841 cacggctggg ccgggctact gaccgtcgtc cgcgccgtcg ccgaagacag cccagccgcg
    12901 gcgcggttca ccccgctgat cgcggacctg caccggcgtc tcgccgccga ccgggaacgg
    12961 ctgcccgaac gcggactcat ggaaggccgg gtgggggcgc agctgcccgt ggaggccacc
    13021 gacgccaccg gctgggcgcg tctcctgctg atcacctgaa ccggacgggc atccgcatgc
    13081 cgccgcacca actaaggagc ttgccacgac catgaaagac gaggacgaac gtcttcccgg
    13141 agccgctgag gaaggctggt ggagcgctag cgtgtggttc gcgggtgagg ctggagtgag
    13201 ctcgcacgcc gctcaggctc tgtgctcgac gctggccgac cagcgcttcc actttgtgcg
    13261 caaggacggc gggctgagac tgcgcacgca gcactgcgca gcccatcacc tggatgccct
    13321 tgtcgccgac caggtggcca cgaggtgggt gggcaccgtc tacgagccgg agaccgaagc
    13381 cttcggcggt agcgcgggca tggccatcgc gcatgccctg ttctgcgccg acagtccctc
    13441 cgccttgatg gagaccggcg ccccgggcgc cagggagcgc tgcgtcctgt tgctgtcggt
    13501 cctgctccga cacgccggcc tggatccgtt cgaggtcggc gacgtctgga cgaagctcgg
    13561 cgcgttgcgg ccaccgctca ccccgcccgc cggctctgcg cgtgacagtg cggtggcggc
    13621 catgcggcgc ctgatgaacg ccgacgccca gcatcggccg aacgccgagg ccgactgggc
    13681 cgagcgcgtc accgcgttca ccgacgccgg ccgccggctg aggtccctgg ccgaccaagg
    13741 gcggctcacg cggggcctgc gggcggtgct ggcccaccat gccgtcttcg ccttcaaccg
    13801 cgccggagtt cccatcgacc agcaggccgc aacggcctgg ctgggcagcc acgtcgcctt
    13861 cgccgatcga caggatgctg acgtgtccac ccatctgtcc gctcattcga caaccgatgc
    13921 aacccgaatg gagaccatga cttccgccac cgaccccgcc gacctgcgcg acgaactcgt
    13981 gaaccgcctc gtcggcagcg gccacctccg cacccccgag gccatcgccg ccttccggga
    14041 ggtccagcgc gaccggttcc tgcccggcgt cgaccagcac gccgcctacg ccgaggacgc
    14101 cgtatccatc aagcacgatg acaccggcga catgatctcc tgcatctccg ccccctccat
    14161 cgtcgccacc caactggagc agctgggcgc ccggcccgga cacagggtgc tggaagccgg
    14221 agccgcaact ggttacaacg ccgccctcct cggccgcctc gtggcgcccg ggggccatgt
    14281 gtggacggtc gacgtcgacc aggacctcgt cgagggcgcc cgcaagaacc tcgccgaagc
    14341 cggcgcctcc aatgtcaccg ccgtcctggg cgacggcgcg gccggttggc cggaccacgc
    14401 cccctacgac cgcatccagt tcaccgtcgg cgccggtgac gtgccggccc ggatcctcga
    14461 ccagctcgcc ccgcacggac gcctggtcct gcccatgcgc atccgcggca gcatctcccg
    14521 cagcttcgcc ttcgaacgtg acggcgacgc ctggaaaacc gtctcgtgcg agatggcgac
    14581 gttcatcccc ctgcgcaagg gcgtgtgcga cgacgtctac acgcgggttc ccatggccgg
    14641 tgagggcaac gtgctcctgg agaccttcag cgagcaggac gtggaccgcg aagcgatccg
    14701 caccgtcctc gaccagcagc aggccaaggt ctactccggc gtgaagttcc gccagggcga
    14761 cccctgggag tggctctacc tgtacctggc ggctgtgctg cccaacggcc tgtcccgcat
    14821 gccgggtgcc cgccccggct tcaccccgca cttcggctgg ggctcgatgg ccgccctcga
    14881 cggcggcagc ctggcctacc tgacggtgcg cgagggcgag gacgcgcagg gccggttctg
    14941 ggagatcggc gtcatcggcc atggcccgtg cgccgacgag ctcgccgagc aggtcgcggg
    15001 cgagatcgtc gcgtgggatg agggctgggg caacaccgcg cccagcccca ccttccgcat
    15061 ggccctcggc gaggcgcgcg accggctgaa gaccaacgat ccgcgcttcg tcatcgacaa
    15121 gcctcacagc cgcctggtca tcgactggcc gcgccgcagc tgagcccatg atccccccga
    15181 tcgccacccg cattccgctg gtgcgtcgcc ccaaggctcc cgcgctgccg ttagagcaac
    15241 gcatcgccca cgtcacgggg ctggccgatg agtccgctgg cgcgagccac cacgacctcg
    15301 tggcccgcgc cagcggagtc ctcaactacg ccgcgctgat cgcctccgac gccgcgctac
    15361 ccgacctggc cgccgacctc tgctggaaac agcaccgcgc cttcgccgac gccggccgtc
    15421 tcaccggaga gatcgcggtc atggcactca tgccgttgat caacctctcc cggctgctga
    15481 cgcgcgaagg cgacggagaa ggcgcctacg acgtactcaa gcagctctac cgcaccgccc
    15541 acgcgcgcag ctcgacccac atccgcggcc acgacgtcga cctatcggcc ctcaccgcca
    15601 cggaatcgga ccaccacgat gtctgcaagg cactgtgggt cgcactcctc gtcgacggcg
    15661 cccgggccct ggcgcgcatc ggatgctgga cccaggccgc cgaagccatg accgcccatc
    15721 gcggcgtcgg gcaccgcctt ctcgacggcc gccagatcat gatcatgtcg ctgatggaac
    15781 ggggccttta ccagcaagcg cgcgatgcga tcgaggccac cgcgcccacc gaagaatggg
    15841 agaacgccat cgcggccctg ctgcaagtgg cctgccgtcc tgcaaccgcg ccggcctccg
    15901 cgcaagaacg ggacgaggca ctgctcgggg cgggagcggt gctcacctcc cctgaccctg
    15961 cgactgcgct gttccagacc cgcgtcggcc tggccgctct tgaactaacc caccaccaca
    16021 ccggccccca caccgccgga ttacacgacc ccatcgtcga cgcggcccgt ctcgacgcct
    16081 acgccgcccg cgacaccctc acccaccccc tcgtcggcgc ccacttggat gaggagcaga
    16141 gaagccacct cgaatccata gtcgccgaat ccgggctcgg cgccggcagg ctttcaccaa
    16201 ctcacatgga gaccctgacc gccgcgtccg aacgcgccga agccgctctc cgcagactcc
    16261 tggcgtgagg ggagttcgtg ctcccgacgg cacctcagag gaggacggcg ccccagcgcc
    16321 atcagccttt gaccaccggg gcctgcgccc ccggtatcga cgcgctgctc accgactctg
    16381 gagaaaggtt cggcggccac gacgatcccg gccacgggca gcagacattg ctgtgaccgc
    16441 acgacgctga gaacggggca aggtgtgacc acgagtctcc cgtccgaggc gaacgggact
    16501 catgaaccgt ggctacggcc acacccgggg aggccgcatc acagacgccg gcgccgtttc
    16561 cagcaaccaa tccactgttg cgccccggct ctggcgcagg ctgtattgcc tgtcgccgac
    16621 ccggacgggc tcggtgtgct gatcgtagcc tgctgcagca acagaggagg cacagtggaa
    16681 cgccatcggc gcggcctaca gacgactttc cgctgtacag cgggagaaca gctagaggca
    16741 gcgtccccga gcgaaccgat cacaaccaag gaacccgcat gcccaactcc gccggccttt
    16801 ccgctaccgt ggcccgcgtt ctggacgaac gctacgggct ggcccctgcg cagctgtctc
    16861 cggtgcgcgg cggccaacac accgtcaacc tgcgcgccga tagtggcaag cgcgcgatgt
    16921 tcgtcaaaac gtacgaggat tccgccgacc tggccaccga acgccgcgcg atcgcgctct
    16981 cggagttcgc cggcgaaaac ggcgtccccg tctcccccgt tatcgacaac cgagaaggcg
    17041 atcccataga caccagctca ccggtggcga tgtcggtatg ggagtggatg cccggcagcg
    17101 cggcccagga actgaaccct tctatcgccg agcaggcggg tcgtgcgcta ggtcatctgc
    17161 accgcgccac cgctgacctg accgaaagcc gtcggcccgc cggccccgtg caggacgcat
    17221 ggcgcggtat tgacaccgac ggcatctccg ccaccatcga ccatctgctc ggcatcatcg
    17281 aggaacgggt acacgcgggg caggccggcc ctttcgacac cctcgctgcc cgcaccctga
    17341 cggagcggcg ggcgatgctc cccgcccttc cctccctcgc cgcggaactt cccggggatc
    17401 tcaccgtcca ggtcttgcac ggcgactacg ccccccgcaa cctgctcttc gacgacgaag
    17461 gacgactcac agccgtcctc gacttctcac cgccaacccc tggactcctc gcttatgaca
    17521 tcggccgcgc cgcgcttttc gccacgactc tcgcgcgcgg cgactggctc gactgcgcca
    17581 acgccctcct caccgcctat ctcgacgtca acccgaccgt cacagcttcg gacctgcaag
    17641 cttgttacca cgtccccgtc attcaacttc tacgcagtct ctacggcatc aaacagcact
    17701 acctcagccc cggcatcgac caggccgacc tcgacgactt ctggcacatg cgccaccgcg
    17761 ccgcccagac tctgctggag catcgcggat caatcgagga catgctcacc aagctggccc
    17821 accacctccc accgacgagg ccgtcgcgat gctgaccggt caggagggcc gatctcgact
    17881 actccaccga cacgccgtcc ctaatcaagg agagccatgt cctgacccac tcgctgggcg
    17941 aacgtcgtcg ctacaccctt cgataccggc attgccacga ggtcggggag gtcgaccatc
    18001 cccatgtcca cgccgcgcac gggcgctctg taaggctgtg aactggacga ggagcggcgg
    18061 caccgggtca gccaagtgcg tgagcggctg gcagctcacg cccacttcga cgacgatgag
    18121 cctcgccacg ccgggagctc accgtgaacg aatcagcagt cgcgacccga tgcgcccctg
    18181 gtcgccctga acctggaagg caccggagcc caggaccgcg acgacgaggc catcctcgaa
    18241 atcggtcttt ccggacgtgg acctcctacc gggtgcatcc aattgccacc ggctccgcgt
    18301 ccgtgccttc tccggcgaag ctgcctgaga accgcctcgt ctatgccgcg ggtgctcact
    18361 ccgccatgca caccgtccgc gaagccgaga tccggctgcg gacctggggg ttggacttgt
    18421 ccccgccgag gcagcacgtc ctcagccaga tcgacaatca ccaccactgc ggtggccggt
    18481 ccgagcgcgg aacccaccgc gatggcggtc gtggcggctc cggcggcagg actcaccccc
    18541 tcatgaaacg ccgggcgatc gacatgtccg aggacggacc acccgtgcga cgcgcccctc
    18601 gcactccgtg cctaccgccc gcgaggggag cagttcagcg atacggcggg gcgcggatca
    18661 tcgacgaagc cgcgctacgg cgtccgctgg gcgacgcgga ggtgatgcgc aagcaaggcg
    18721 aatacctgct gcgcgtgggg caactccccc acatcgacct ccaggtgctg ccgttcagcg
    18781 tcggtgcgca tgcggcgctg ggctcagcgt tcaccgtcct cgacttctta ggggcggtgg
    18841 atccaacgat catcttcacc gacagcatcg gcggcggatt gttcgaggaa tcgcccgagg
    18901 aggtcgacca gtacgtggcg atcttcggcg acgtccaggg cagcgcttga gtaccgtcgc
    18961 cagcgcccag ttcatcgagg atgcccggtc caccccgaag aagtgagcac catgtcccac
    19021 cccacacctg agttccgcaa gagcagctac tccacccgga actcgcagaa ctgcgtcgag
    19081 gtcgccgacc tggacggcgg tgccggcgcc gtccgcgaca gccagcaccc cgaccacggg
    19141 cgcctggagt tcacctccgc cgaatggcgg gccttcctcg cccacgtcaa gtcggaccag
    19201 gtgtagctcc accgccacaa cacgtcggcc cctccaccgt gctggtgagg ggccggcgcg
    19261 cacctgagtg ctccgcagag catcgcggca agcctaacca tggctggcca cggcttcgga
    19321 ggaacgtcgg gacagcacgt ctacgagcgt ccaccctccg ggctttcccg ggagcgtccg
    19381 tccggtcggc gaggattccg cgaccggaga ctcgaatgcc aagtcgtaga gtggtcggtg
    19441 gtggtcggca tcgtcgcccc tgctacgcac gcgccgcgtt tccacacatg gcgtcggcgg
    19501 gcgaggaacc agggctcgcc acctcccagc atcacaatgt ctggttggga agcgcatgat
    19561 tcggtctgtt gtctttgatg tcggcgagac gctgctagac gatactcgtg agtgggcccg
    19621 gtgggctgac tggattcagg tgccgcggca caccttctct gcggtgctgg gtgcggttac
    19681 cgcgcaggga cgcgataact ccgagacctt cacctacttc aaacccgatt tcgacctcgc
    19741 gcgtgagcgg caggcccgcg aggaggcaga ccagggcgaa cacatcgaag agactgatct
    19801 ctactccgac gtacgaccta cgctccaagc gctacgagat cagggagcgt ggctcggtat
    19861 tgccggaaac cagacacggc gcgctgcaga actattgcgc cagctggatc ttcctgtcga
    19921 tctcatcgcc acctcgggtg aatggggtgt cgccaaaccc gcacatggat tttttgaaca
    19981 tgtcaaatat atggcgtcgg ggactgcccg tgagatcgtc tatgttgggg accaccgaga
    20041 caacgacgtc cttcccgccg cggctgcagg tctgaacagt gcactgatcc gccgcggccc
    20101 ctgggggtac ctgtgggcgt cagactctcg ggtgaccaca cacgccacct gggtaatcga
    20161 ctcgcttgct gaacttcccg atttgctcag gccgtagcct gcatctgcct tgccgattga
    20221 ctatcagggg ggcggtaccc cctgaaccgc gtccccgtcg tgtgggcagc gctgaatcct
    20281 cccaccaggg caaatgtccc tgcccgggac tgacggaggt ggaagggaat gtacccccag
    20341 ttcccggcag gttcagaaag ccctccaggt ccatggacgg gggatgtcac cgcgcagaca
    20401 ccggatgcgg tgccgggcct cctctgcggc accggggcgg gttgcggcct tgctgagggt
    20461 gaaacacacc cagcgcaact cttgaatctc cgccagggtg ccgaagccgg gtgcggtggt
    20521 cacgtcatag ccgccgtagg cggtgacgaa ggcgttgtag tcctcgtcgg agatccgggc
    20581 gaagtcggta tggtccacgg ccagggagac cagatcggcg tcccgcgggc cgagggcgac
    20641 cttctcaagg tccaacacga tgggcggacc ttcctcgggg acggccacgt tgccttgcca
    20701 ggcatcaccg tgaaccactc cgcagcctcc cacagcgcca agcttcaggt gctgctcacg
    20761 aaggtcggca aggcgccgag tcagccatgc tcgatcttcg ggatccaacg cctgggcggt
    20821 actgatgtgg tcgggatcga tgccggcgaa cggatcgaac cgaggcagcc gcagttcttc
    20881 gggtatcggc agcctgtgaa tggtgcctag gacagcaccg agctcgcccg gtgtggcggg
    20941 ccggtggggt ggcagcaaac gccaccaggt gaccgggcta ccgtcgatga cggtcggctg
    21001 gggaacgccg gtaagggcgt ggacgaccgg caccgcgcag ccttccaacc agcgggaaac
    21061 gtccacttcg cgctcggcga ccgcgcaggt ccccggccgc ccgacgcggg cgacgacgcg
    21121 atcgggcagc cggtagagga cgttggcacc atcgcggatc agttcagcgc cgtcggcctt
    21181 gatgcccgca gcgcgtgccg cagcggtaag gacggcactg gtgtcgagga cgtgggagct
    21241 cacgcagaga tcttctcagg tgttttcggt cgccacggca acggcgtcgc ggatcaggtc
    21301 ggcgacgtcc tccaacaggg cgcgcttccg gggccatggc cgatgacgcc gaactcccag
    21361 agcttttcgt cctcagctgt cttctcgttc agcagccgcc gggcgaggta ggtgaccgct
    21421 cccttgtcca cggccgccgt ggaggacggg tacgggtcct cggtaagcac cgtgcccttg
    21481 gcggtctgcg ggaacagcat ccggatcagg ccggagggca gggagcagga gacgaacagc
    21541 tccatccact ccgggctctc catggctcgg accttcatgc cggcggcgag gtacatccgg
    21601 cggccgtcgc atgccaccgc gaggtcagcc ggggtgagta cggcggcgga ggcgacccgg
    21661 tgttcttgca ggctttatga ccagtggcag aacggaaggg ggccgggtca cgtggtcggt
    21721 gtcgggcagc agtgggggga aggagagctg ggcgggaacg gtatcggcgt cggcagcagg
    21781 cagatcggcc ctacatgggc tgagttcccg gccgccgctc cagcgcacac ggcacgcgcg
    21841 gagcggcgcc ccggcgcccg cacgtcggcc accacccacg ttctctggag gaggccgtgt
    21901 tccacgttcg tcgggcgtgt cttctgtcag cccgccgccc ccgacctcgc cctcacccgc
    21961 cagcgcctga gtgaccttga cgctcgctga tggggcctat aggacagcga ggacagtctc
    22021 actaccgcgt gcgccgtccc gtaggtcgct ctggggctag ggtcgctgga gcggctctgg
    22081 ttgcggcgag tagaagtgga cgggcatgga caacgaaagc accgcgcggc tggctgtact
    22141 catcgacgcc gacaacgctc agccctccat cgccgtcaac ctgctggccg aggtcgccca
    22201 gtacggaacc gcccacgtca agcgcgccta cggcgactgg accggcacgt ccctcaaggg
    22261 gtggaaggag cagctgctca cccaatcgat ccagcccatg cagcagttcg cgtacagcac
    22321 cggcaagaac gccaccgacg cggccctggt gatcgacgcg atggacctgc tgtatacgga
    22381 ccgcttcgac gggttctgca tcgtctccag cgacagcgac ttcacccgcc ttgccgcgcg
    22441 tatccgtgaa tccggactga ccgtctacgg gttcggggaa cgcaaaacgc ccaagccgtt
    22501 cgtttcggcc tgcgacaagt tcatctacac cgagaacctc gtctccaccc agaaaacgcc
    22561 ggcggagacc gaacagccac tgcagcaggg gcaggccaat ggtgcttccg tcctcccggc
    22621 ctcggacgct ggactggcga gcctattgcg cgaggtggtc gccgcggctt ccaacgacga
    22681 cggctgggcg cacctggcag ccgtcgggag catcgcccgc aagcgccaac ccgacttcga
    22741 cccccgcagc tacggccacg ccaaactgat gagcctgatc gaggcgaccg gactgttcaa
    22801 tctggccaaa cgcgatcccg gcggcgggaa tcctcccgtc gtctacgtcc gcgaccgcag
    22861 ccgcgcaagc tgatgcccac cgcggggcca tggcgggacg cggcagatca gactgccgcg
    22921 ctggagacac tgtcgaccgg ccaccgcacc ggtaccggga cgtcggcggc gttccccacc
    22981 cgatcaagaa cgagatgacg gcgtcgtagg atctccggcc tcctgcgagg cgagcacggc
    23041 ttggccccac tggaccagca ccgccgcact ctgcaccagt tcctcgagca actcccgatc
    23101 gtcggcggca cgcgcttcgc tcaactcttc gaacgccagg tcgtagaacg taggcggatg
    23161 cccggcgtcg tcgacgttgc tctgtgcgcg ctcggcttga ggccggtgct gggggccgtt
    23221 gccggaggac aggttctgga tgccatacat ccgctcctgc cgccggcgct ccgcggcgat
    23281 ccggttgaac atgagctcta gcgagccggg cacgcccgcg tctccgaggt ccgcctcggc
    23341 ggcgggacct gacgcggccg cggtttcccc gttgtgcggg aacctatgga gggagaacgg
    23401 ggcaccggtc aggtaggcct cgatcgcttg ggcgcagtag ccgacggtcg catccggcag
    23461 ccggtgggcg gggttccagg cgatctgcgc gtgcttgtcg ggttcggcgt tgaccggcac
    23521 tccttcccac gttcgggcgg cgaagaagac gtgcaggcgg ctcccgttct ccgcgctgtg
    23581 catgacgtgg gccggttcca ggtcaccggg cgccagcacg atccccagct cctcgcgggc
    23641 ctctcgaacc gccgcgtcga cgaccgactc gtgtggctcg accttgcccg ccacgctcgc
    23701 atgccagtac agcggggcgt aggcagcgtt cgcgctgcgc cgggtaagca gcacccggcc
    23761 gcggtcgaaa agcagcacgt gcgctgcgag gacggcggcg gatcgggctt cctcgctcgc
    23821 caggttctcg aacatacgat cgcacatagt gccagcatgg cctgaagtgt gtccgcgccg
    23881 cagctaaaca acgaatgacg tcaagacggg ccgctatagc tctccatttg gcacgccggt
    23941 gcactcgacg ccgtcctggt ccgcagcctc cgtcgccctt ccactgtctg gagattgctg
    24001 gccggacggc tccaccgttc cgagaacgtc gtcaactggc ggtccgcctc tcgggccctg
    24061 cccccagcga cggctcgccg ccacccacaa catgggccgg tgaccaccga acatttccgg
    24121 cagtgtggtg cgcgaggtcc gagcgacgac acccaatatt gggccgactg ctggcgaccg
    24181 ctcaaacgca cactccgtcc cggaatttgc ggcggccacg accgggcctg cgacatcgtg
    24241 gggaccgtgc agtccgccat ctagcccatc tatttgtcgc tatcgacctg gctgcggccg
    24301 ccgagcaaat cgaacacctc accacaggga gcgacgcatg agtcacttca ccggaaccgc
    24361 tacatactac cgccggtacc gtcccggcat tcccgacgat gtgacgtcgg ttctcgacca
    24421 cgccgccccc acccgttcca aaggtcggcg gcgcctcctg gacgtcggca ccgggaccgg
    24481 gctggtggcc gaggccctgc tggatcgctt cgacgacatc atcggcgtcg acagcgacgc
    24541 cgacatgctg gccgcggccg agtcggcgct gcgtcccaag ctccccgagc actcccgctt
    24601 atccctcgtc cagagcacgg ctgaggactt caccccgccc accggctggc aggccgaact
    24661 cgtcaccatc tgccgcgcgt ttcactggct cgaccaaggc acggtcctgt ccctgctgga
    24721 cgagcaggtc gctcccgacg gcgtggtcgc catcttcagc gacagcagct tctggaccgc
    24781 cagcagcccg tggaaggaag cagtccgcga cgtcgtgaag agctgcctcg gcgaggaacg
    24841 gcgcgcgggt gccggtacgt ttcagcacca caaccgcccc tatagcgacc tcctggcgga
    24901 atcacccttc gacgcagtcg aggaagtccg cgtacccgtc gagtgcacct ggaccgcgga
    24961 aagcatcctc ggctacctct actccacatc cttcgccgca ccccacctct tcggggaccg
    25021 ggtcaaggaa ttcgaggccg ccgtgaagca ccggctggcc gagttcagcg gcgacgacac
    25081 gttccccgag gagaacgagt tcctcatccg tctgggacgg cgcagccgca atggcggctg
    25141 agagccaggt gcggttacgg gca
//
