LOCUS       NZ_CP036455            10375 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Streptomonospora litoralis strain M2 chromosome, complete genome.
ACCESSION   NZ_CP036455
VERSION     NZ_CP036455.1
KEYWORDS    RefSeq.
SOURCE      Streptomonospora litoralis
  ORGANISM  Streptomonospora litoralis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 5724192)
  AUTHORS   Khodamoradi,S., Hahnke,R.L., Kaempfer,P., Schumann,P., Rohde,M.,
            Steinert,M., Luzhetskyy,A., Wink,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2019) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.3x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004323735.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,076
            CDSs (total)                      :: 5,002
            Genes (coding)                    :: 4,957
            CDSs (with protein)               :: 4,957
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 6 of 46
            Pseudo Genes (incomplete)         :: 39 of 46
            Pseudo Genes (internal stop)      :: 2 of 46
            Pseudo Genes (multiple problems)  :: 2 of 46
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:19:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3655289
            Orig. end                         :: 3665664
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10375
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="11"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10375
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10375
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5375](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5375
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            440..1324
                     /locus_tag="EKD16_RS26160"
                     /old_locus_tag="EKD16_15755"
     CDS             440..1324
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013722.5"
                     /locus_tag="EKD16_RS26160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15755"
                     /product="MaoC/PaaZ C-terminal domain-containing protein"
                     /protein_id="WP_131099019.1"
                     /transl_table=11
                     /translation="MTAPRPATDDTAPPPEPAPASHVMADGSRMALHRAALRADLGPAS
                     TPEPSPIYPFVLAHPVADATVRGMADDGAESPSVVHLGQEIRIRRLPRPAEEIGAAPEV
                     LAVRAQPGGCNVAVRITLTDAAGEPVAVLLSTVLLSGASPAPFGTAHRMSAPARSGSGE
                     AVGVTHRLSEEWIADYAEASGDRNPIHLDPAAARAAGFDTVIAHGMGVLGLACEEVVDR
                     FAAGSPARVRSIGARFSAPVGAGEPLTMALEPDADPAGGPVAFSCRTGRGLAVKGGWVE
                     LHPARGAAEPDDG"
     gene            1317..2843
                     /locus_tag="EKD16_RS15365"
                     /old_locus_tag="EKD16_15760"
     CDS             1317..2843
                     /NRPS_PKS="Domain: AMP-binding (12-394). E-value: 5.4e-71.
                     Score: 231.2. Matches aSDomain:
                     nrpspksdomains_EKD16_RS15365_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017604167.1"
                     /locus_tag="EKD16_RS15365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15760"
                     /product="AMP-binding protein"
                     /protein_id="WP_131099020.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-64, bitscore:
                     216.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAELADPLAGILHQVRHRPQAPALHWRGTRVTYGGLYERARRECD
                     RIARLDSHPGEPVAVLADKSPEAVALILACLLLRRPFLLPSTALADTQLADLAAQAGCR
                     QVLTPEGAPGRPLPPGREQRRTPPPGTTFMLTTSGSTGLPKVVPLEAAAVHRFAAWAAP
                     AFGIGPGTPVLNYAPLNFDLCLLDVWASLARGAQVVLVDPERGLDGRYLLDLVLGYGVQ
                     VVQAVPMAHGLLADAAAARGADAPSVRHALFTGDVMPERTLSALPGLFPRARLYNVYGC
                     TETNDSFVHEVPRAEARAAQGPPPIGTPLPGVRALVLDERGQQIDGAGAGELYVRTPFQ
                     SPGYLDAAKRAERFAGHPLGQDDGRWYRTGDLVERDAAGCLRLTGRADFQVKIRGTAVN
                     TAEVERVLLKHPDVLEAGVAAVADPETGRRLVSAVHRAPGSGLNSLTLRGHLSRNLPRA
                     AVPPVLRISDEPLAKTPTGKVDRGVLDHPAGGSDRRREAGNEPTAKGSPL"
     aSDomain        1353..2498
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKD16_RS15365_AMP-binding.1"
                     /evalue="5.40E-71"
                     /label="EKD16_RS15365_AMP-binding.1"
                     /locus_tag="EKD16_RS15365"
                     /protein_end="394"
                     /protein_start="12"
                     /score="231.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HQVRHRPQAPALHWRGTRVTYGGLYERARRECDRIARLDSHPGEP
                     VAVLADKSPEAVALILACLLLRRPFLLPSTALADTQLADLAAQAGCRQVLTPEGAPGRP
                     LPPGREQRRTPPPGTTFMLTTSGSTGLPKVVPLEAAAVHRFAAWAAPAFGIGPGTPVLN
                     YAPLNFDLCLLDVWASLARGAQVVLVDPERGLDGRYLLDLVLGYGVQVVQAVPMAHGLL
                     ADAAAARGADAPSVRHALFTGDVMPERTLSALPGLFPRARLYNVYGCTETNDSFVHEVP
                     RAEARAAQGPPPIGTPLPGVRALVLDERGQQIDGAGAGELYVRTPFQSPGYLDAAKRAE
                     RFAGHPLGQDDGRWYRTGDLVERDAAGCLRLTGRADFQVKIR"
     CDS_motif       1713..1766
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKD16_RS15365_0001"
                     /evalue="6.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="EKD16_RS15365"
                     /protein_end="150"
                     /protein_start="132"
                     /score="12.7"
                     /tool="antismash"
                     /translation="FMLTTSGSTGLPKVVPLE"
     CDS_motif       2466..2528
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKD16_RS15365_0002"
                     /evalue="8.50E-07"
                     /label="NRPS-A_a8"
                     /locus_tag="EKD16_RS15365"
                     /protein_end="404"
                     /protein_start="383"
                     /score="21.5"
                     /tool="antismash"
                     /translation="TGRADFQVKIRGTAVNTAEVE"
     gene            2840..3103
                     /locus_tag="EKD16_RS15370"
                     /old_locus_tag="EKD16_15765"
     CDS             2840..3103
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615300.1"
                     /locus_tag="EKD16_RS15370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15765"
                     /product="acyl carrier protein"
                     /protein_id="WP_131099021.1"
                     /sec_met_domain="PP-binding (E-value: 0.00016, bitscore:
                     20.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.0013, bitscore:
                     17.1, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSHTDAIRQFVITEFLPDLDPGDLADDHDLITDSVIDSVGTLKLI
                     AWVENTFDLRVGDTELDPDNFRTVTAIDSFIARMREAEAAEN"
     gene            3106..4164
                     /locus_tag="EKD16_RS15375"
                     /old_locus_tag="EKD16_15770"
     CDS             3106..4164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579242.1"
                     /locus_tag="EKD16_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15770"
                     /product="anthranilate phosphoribosyltransferase"
                     /protein_id="WP_131099022.1"
                     /transl_table=11
                     /translation="MHEVITALLNRRPVTRAEDWRSLWDRLGSGGLDRAEAAALLGSLA
                     THPPEAPTLRALLDSLSRRPAASADRCWPATVNTVGTGGGPSTFNVSTAAAFVAAAMGV
                     RVVKTGSRAYSSRLGSVDLLERLGVRLTGSLEETADAVDRDGIAFAGPFVYPPELTALA
                     RAMAPVALRPFGRFLNAVGPFLADLPVAAQVTGVSAAMPLAELRQVAQGVDDRLIWLCT
                     NDLGADELLGFCDNTVYSNAAGGGTPVLRLRRGELLPERGGIEDLRPFEPDDAVRRFRE
                     VLAGPPGAATDTVCLNAAAAAVAAGAADDWPQALDAAREAVAEGAALALLDRLRERSQT
                     PGTLQASGGRHG"
     gene            4157..4990
                     /gene="trpA"
                     /locus_tag="EKD16_RS15380"
                     /old_locus_tag="EKD16_15775"
     CDS             4157..4990
                     /EC_number="4.2.1.20"
                     /GO_function="GO:0004834 - tryptophan synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000162 - tryptophan biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trpA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579241.1"
                     /locus_tag="EKD16_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15775"
                     /product="tryptophan synthase subunit alpha"
                     /protein_id="WP_131099023.1"
                     /transl_table=11
                     /translation="MADFFSHRPAGRVGLAVFLNAGDPPLDVLADVVHMLDEAGVECLE
                     LAVPFPDSVTDGPVVQRSARRALDRGTDLDAVLAFVSRIRPRLARMRIALLADWSHSLS
                     PRGLGEALGDVAESGADALLTHALPPRMRDEYYRAARESGVAVVTTCYPQSRPEVAAEA
                     AANATGYLYLVARYGRSGTGPVGGHAALAGTVRRLRESTAAPIALGFGVRTRADVAAVA
                     ASGADAAVIGSAGVTRVEEAQEQGADPAARLREFVLECRPPLPDQTAQESANSTA"
     misc_feature    complement(4998..5011)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.33"
                     /tool="antismash"
     gene            5001..5375
                     /locus_tag="EKD16_RS15385"
                     /old_locus_tag="EKD16_15780"
     CDS             5001..5375
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615297.1"
                     /locus_tag="EKD16_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15780"
                     /product="ectoine synthase"
                     /protein_id="WP_131099024.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.1e-31, bitscore:
                     107.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIRDIENVKTVDWGNGLSRRFLLQEDGVGYSITDTIVSAGTRSR
                     LEYRNHLESCYCIEGSGAVIELDGTVHPLRPGRMYSLDKHDAHFLVADPDTDLRLVCVF
                     TPALQGDEAHRLDESLASAY"
     gene            5384..6529
                     /locus_tag="EKD16_RS15390"
                     /old_locus_tag="EKD16_15785"
     CDS             5384..6529
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615296.1"
                     /locus_tag="EKD16_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15785"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_131099025.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.1e-16, bitscore:
                     59.6, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.2e-23, bitscore:
                     81.3, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8e-28, bitscore:
                     95.7, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEATTEAAELRKGLADWAKDLSEGHIEADEAGEFPWHKWRMIQR
                     SGLLGLPFAQPWGGLERSLPEVLHVLEGLGEYCRDSGLSFCATTTMASTGVPVERFGTA
                     EQQKRYLPGICSGELIGAHAITESESGSDALRMATRAEPDGDGFVLHGSKLFVTNAPIA
                     DVFVVYARTHPDGGPLGTTAFLVDRDTPGLTCGAPARKMGLRTAPMSELSLDGVRVARD
                     RVVGRVGGGFLVMDHVMKREILFTAAVHAGEMEHRLQRCLDYAKSRHAFGRPIGSYQSV
                     TNRIAEMRIRLDTARKWIFDTGERLAAGHDVTVDLAATKLVTSEANVAGSLAAVAIFGG
                     HGYMVEQGMEKEVRNAVGGTVYSGTSDIHYNRIAAALGLDP"
     gene            6595..7260
                     /locus_tag="EKD16_RS15395"
                     /old_locus_tag="EKD16_15790"
     CDS             6595..7260
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017579237.1"
                     /locus_tag="EKD16_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15790"
                     /product="N-(5'-phosphoribosyl)anthranilate isomerase"
                     /protein_id="WP_242676987.1"
                     /transl_table=11
                     /translation="MSAREVAAAAAGGADCVGLWHGIPGGRAELAEHTARGLAAEARSH
                     GVEPVLVTFGDDPAALAAAADRTGVRWVQLHAYQLPRVVGGLRERAPGAVPVKVLHVDG
                     GGRCLELRLADAYARAGTEMFLLDTATADGRVGSTGQALDAVGVLRIADRLPRPFLLAG
                     GVTAARRADYDRVVEHPMFAGVDVDTGARGGDGELSETAVTELSRAWRTGRGRRKERS"
     gene            7260..8018
                     /locus_tag="EKD16_RS15400"
                     /old_locus_tag="EKD16_15795"
     CDS             7260..8018
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615294.1"
                     /locus_tag="EKD16_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15795"
                     /product="indole-3-glycerol-phosphate synthase"
                     /protein_id="WP_131099027.1"
                     /transl_table=11
                     /translation="MAHDFIDALLGAERPVIAEIKRRDSHGRDLFAGRGPADIVSAYEQ
                     AGAPCLSVVTGSWFGGSEALLAETAELTRLPLLQKDFVTRRDQITRAADLGAAAVLITA
                     ELLPRPALQSLVASCLDTGLTPFVEVTEQPQAAAVPHAEQCVIAVNNKNIRTRERDAGD
                     TGRSLTLLPALLEAGTRCPVSASAVPDPHVGARLLDAGFAGLLVGTALLRDGDPRGWLD
                     TVARRRQVPPAQPPAGTEVADAPAPLGGRP"
     gene            8015..8896
                     /locus_tag="EKD16_RS15405"
                     /old_locus_tag="EKD16_15800"
     CDS             8015..8896
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (44-152). E-value: 4e-11.
                     Score: 34.9. Matches aSDomain:
                     nrpspksdomains_EKD16_RS15405_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615293.1"
                     /locus_tag="EKD16_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15800"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_207391312.1"
                     /sec_met_domain="PF00561 (E-value: 2e-08, bitscore: 32.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 8.3e-12, bitscore:
                     44.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAPPRAAPAGADIRRIRLDAGGITLSGLLARPTGPPRPGGANRP
                     VVLAVHGRSMRADYFHARTHPDLSLLDVAVARGHTVVALDRPGYGASAERLPEGQTVDE
                     QSATVHAALRSFSADHAARAGFVVLAHSHGGKLALRLAADDSAGRIRGLDISGCGVEYS
                     AAARGLPSSLGAGASRLNWGPLRLYPPGTFQQARSLLAPTPPREDGEWLRWPHQYRDLA
                     PRVRVPVRFTFADHEAWWRLGDSDLAELAGALTAAPRVGVHRHPDAGHNISLGWSARAY
                     HLRALEFLEACR"
     aSDomain        8147..8470
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKD16_RS15405_Abhydrolase_1.1"
                     /evalue="4.00E-11"
                     /label="EKD16_RS15405_Abhydrolase_1.1"
                     /locus_tag="EKD16_RS15405"
                     /protein_end="152"
                     /protein_start="44"
                     /score="34.9"
                     /tool="antismash"
                     /translation="PVVLAVHGRSMRADYFHARTHPDLSLLDVAVARGHTVVALDRPGY
                     GASAERLPEGQTVDEQSATVHAALRSFSADHAARAGFVVLAHSHGGKLALRLAADDSAG
                     RIRG"
     gene            complement(8916..9668)
                     /locus_tag="EKD16_RS15410"
                     /old_locus_tag="EKD16_15805"
     CDS             complement(8916..9668)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017624204.1"
                     /locus_tag="EKD16_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15805"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_131099028.1"
                     /transl_table=11
                     /translation="MRARCLIVDDEAPARADLRYLMSRFDHVQVVGEASNAEEALLLLD
                     SLDYDLVLMDIRMPGGTGLDVARKLREAAHPPRIIFTTAFPDYAVEAFDLDAADYLVKP
                     FDAERLERALDRALAARPEEGEPQPEPPRRSDGADSPHRIPVHKGDRTVLLNESSIIYA
                     GAARGYSYLQLADERVLVNFSLNELERRLRGAHFFRAHRSYLVNLDYVRELAPDFRGTL
                     MLLMDDPRKSRVEVSRRQARELRRVLGL"
     misc_feature    complement(9664..9677)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.67"
                     /tool="antismash"
     misc_feature    complement(9685..9699)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.73"
                     /tool="antismash"
     misc_feature    complement(9721..9739)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.22"
                     /tool="antismash"
     misc_feature    10300..10314
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
ORIGIN
        1 cctccgacgc ctaccacctg tccatgcccc gccccgacgg cagcggcgcc gccgacgcca
       61 tggcccaggc catctccgac gcggggctgg cgccctccga catcgtgcac gtcaacgccc
      121 acggcaccgc cactccgcac aacgaccggg ccgaggccgc agcgctgcac cgggtgttcg
      181 gcgcccacca gccgccggtc accgcgccca agggcgtcct cgggcatttg atcggcgcgg
      241 ccggcgccgt cgagctcgta gcgacggtgc aggccatggc gcgctgcgag gtcccgccca
      301 cggccaacca cgagcgggcc gaacccggcc tggagatcga cgtcgtgcac ggtgaaccgc
      361 gcgcggtgca ctcgggcccg gcactgacca actccttcgg attcggcggc cacaacgccg
      421 ccctggtggt gacacccgga tgaccgctcc ccgacccgcg accgacgaca ccgctccgcc
      481 gcccgagccc gccccggcat cccacgtcat ggccgacggg agccggatgg cccttcaccg
      541 cgccgccctg cgcgccgacc tggggcccgc gtcgacgccg gagccctccc cgatctaccc
      601 gttcgtgctc gcccaccccg tggccgacgc caccgtgcgc ggcatggccg acgacggcgc
      661 cgaatcgccg agcgtcgtcc acctcggcca ggagatccgc atccggcggc tcccccgccc
      721 cgcggaggag atcggcgccg ccccggaggt cctggccgtg cgcgcgcaac cgggcggctg
      781 caacgtcgcc gtacgcatca ccctgacgga cgcggcgggc gaaccggtgg ccgtgctgct
      841 cagcaccgtg ctgctgtctg gggcgtcccc ggccccgttc ggcacggcgc accgcatgag
      901 cgcgccggcc cgaagcggat ccggtgaggc cgtcggcgtg acccaccgcc tgagcgagga
      961 gtggatcgcg gactacgccg aggcgagcgg cgaccgcaac cccatccacc tggaccccgc
     1021 ggcggcgcgc gcggcgggct tcgacacggt gatcgcccac ggcatggggg tgctggggct
     1081 ggcctgcgag gaggtcgtcg accgcttcgc ggccggctcc cccgcacgcg tccgctcgat
     1141 cggcgcgcgc ttctccgcac cggtgggggc cggtgagccc ctcaccatgg ccctggagcc
     1201 cgacgccgat cccgccggcg gccccgtcgc gttctcctgc aggaccggac gcggtctggc
     1261 cgtcaagggc ggctgggtgg agcttcaccc cgcccgcgga gctgcggagc cggacgatgg
     1321 ctgagctcgc cgaccccctc gccgggattc tgcaccaggt gcggcaccgg ccccaggcgc
     1381 ccgcgctcca ctggcgcggc acccgggtga cctacggcgg cctctacgag cgggcgcgcc
     1441 gcgaatgcga ccggatcgcc cgcctggact cgcatccggg ggaaccggtc gcggtgctgg
     1501 ccgacaagtc gccggaggcg gtggcgctga tcctggcctg cctgctgctg cggcgcccct
     1561 tcctgctccc ctcgacggcg ctggccgaca cccaactggc cgacctggcc gcccaggcgg
     1621 gctgccggca ggtgcttacc cccgaggggg cgcccgggcg gccgctgccc ccggggcggg
     1681 agcagcggcg cacgccgccg ccggggacga cgttcatgct caccacctcc ggctccaccg
     1741 gactgcccaa ggtcgtgccg ctggaggcgg ccgccgtgca ccggttcgcc gcctgggcgg
     1801 ccccggcgtt cgggatcggc cccggcacgc cggtgctcaa ctacgccccg ctgaacttcg
     1861 acctgtgcct gctggacgtc tgggcgtcgc tggcccgcgg cgcgcaggtc gtgctggtcg
     1921 accccgagcg cgggctcgac ggccggtatc ttctcgacct ggtgctgggc tacggcgtgc
     1981 aggtcgtgca ggcggtgccg atggcccacg ggctgctcgc cgacgcggcc gcggcacggg
     2041 gcgccgatgc accctcggtg cggcacgcgc tgttcaccgg cgacgtcatg cccgaacgca
     2101 cgctctccgc gctgccggga ctgttccccc gcgcccggct gtacaacgtc tacggctgca
     2161 ccgagaccaa cgacagcttc gtccacgagg tcccccgcgc cgaggcgcgc gcggcgcagg
     2221 ggccgccgcc catcgggact ccgctgcccg gggtgcgggc gctcgtcctg gacgagcggg
     2281 ggcaacagat cgacggggcc ggggcgggcg agctgtacgt gcgcacgccg ttccagtcgc
     2341 cgggctacct cgacgccgcc aagcgcgccg agaggttcgc cggccacccg ctgggacagg
     2401 acgacggccg ctggtaccgc accggcgatc tggtggagcg cgacgccgcc ggctgcctgc
     2461 ggctcaccgg gcgtgccgac ttccaggtca agatccgggg aaccgccgtc aacacggccg
     2521 aggtggagcg ggtgctgctg aagcaccccg atgtgctgga ggcgggggtc gccgccgtcg
     2581 ccgaccccga gaccggccgc cgcctcgtct ccgcggtgca ccgcgccccc gggtccggcc
     2641 tcaacagcct cactctgcgc gggcacctgt cccgcaacct gccgcgagcg gccgtaccgc
     2701 ccgtcctgcg gatcagcgac gagccgctgg ccaagacgcc gaccggaaag gtcgaccgcg
     2761 gcgtcctcga tcacccggcg ggcggctccg accgccgccg ggaagccgga aacgaaccga
     2821 ctgcgaaggg aagcccgcta tgagccacac ggacgccatc aggcagttcg tcatcaccga
     2881 gttcctgccc gacctcgacc ccggcgacct cgccgacgac cacgacctca tcaccgacag
     2941 cgtcatcgac agcgtcggca cgctcaagct gatcgcctgg gtggagaaca ccttcgacct
     3001 cagggtcggc gacaccgaac tggacccgga caacttccgc accgtcaccg cgatcgactc
     3061 cttcatcgcg cggatgcgcg aggccgaagc ggcggagaac tgaccgtgca cgaggtgatc
     3121 accgccctgc tgaaccggcg cccggtgaca cgggccgagg actggcggtc gctgtgggac
     3181 cggctcggct ccggtgggct ggaccgggcc gaggcggccg cgctgctggg ctccctggcc
     3241 acccacccgc ccgaagcgcc caccctgcgc gccctgctcg actcgctctc ccggcgcccg
     3301 gcggcatcgg ccgaccggtg ctggcccgcg accgtcaaca ccgtcggcac cggcggcggg
     3361 ccctcgacgt tcaacgtctc caccgcggcc gcgttcgtgg cggcggcgat gggcgtgcgg
     3421 gtcgtcaaga cgggctcgcg cgcctacagc agccgactcg gctcggtcga tctgctggag
     3481 cggctggggg tgcgcctgac cggctcgctg gaggagacgg ccgacgccgt ggaccgcgac
     3541 ggcatcgcct tcgccggccc gttcgtgtat ccgccggagc tgaccgcact ggcgcgggcc
     3601 atggcgccgg tggcgctgcg gcccttcgga cgcttcctca acgccgtcgg ccccttcctc
     3661 gccgatttgc cggtcgccgc ccaggtcacg ggcgtctcgg cggccatgcc gctggccgag
     3721 ctccgccagg tggcacaagg cgtcgacgac cgcctgatct ggctgtgcac caacgacctc
     3781 ggcgccgacg aactgctcgg tttctgcgac aacaccgtct actccaacgc cgcaggaggc
     3841 ggcacccccg tgctgcggct gcgccgcggc gaactgctgc ccgagcgcgg cggtatcgag
     3901 gacctgcggc cgttcgagcc ggacgacgcc gtacgccgct tccgcgaggt gctggccggt
     3961 cccccgggtg cggccaccga caccgtctgc ctcaacgccg ccgccgccgc ggtggcggcg
     4021 ggcgcggccg acgactggcc gcaggcgctg gacgccgccc gggaggcggt cgccgagggg
     4081 gccgccctcg ccctcctcga ccggctgcgc gagcggtccc agacgccggg aacgctgcag
     4141 gcgagcgggg gccgccatgg ctgacttctt ctcccaccga ccggccggcc gtgtgggact
     4201 ggccgtgttc ctcaacgcgg gcgacccgcc cctcgacgtc ctggccgacg tcgtgcacat
     4261 gctggacgag gcgggcgtcg agtgcctcga actcgcggtg ccgttcccgg actcggtgac
     4321 cgacgggccg gtggtgcagc gctcggcgcg gcgcgcgctc gaccgcggta ccgacctcga
     4381 cgccgtactc gccttcgtct cgcggatacg gccccgcctg gcccggatgc gcatcgcgct
     4441 gctggccgac tggagccact cgctgagtcc gcgcggtctc ggcgaagcgc tcggcgacgt
     4501 cgccgagtcg ggggccgacg cgctgctcac ccacgccctg ccgccgcgga tgcgcgacga
     4561 gtactaccgg gcggcgcgcg agagcggtgt cgccgtagtc accacctgct acccgcagtc
     4621 gcgcccggag gtcgcggccg aggccgccgc caacgccacc ggatacctct acctcgtggc
     4681 ccgctacggg cgcagcggca ccggcccggt cggcgggcac gcggcgctgg cgggcaccgt
     4741 ccggcgcctg cgggagagta cagccgcccc gatcgcgctg ggattcggag tccgcacacg
     4801 cgcggacgtg gcggccgtgg ccgcctcggg ggccgacgcc gccgtcatcg gatcggcggg
     4861 ggtgacccgc gtcgaggagg cccaggagca gggcgcggac ccggcggccc ggctgcggga
     4921 gttcgtcctg gaatgccgtc cgcccttgcc cgaccagacc gcccaggaat ccgccaacag
     4981 cacggcatga ggagcagcgc atgatcatcc gggacatcga gaacgtgaag accgtcgact
     5041 ggggcaacgg gctgagccgg cgcttcctgc tgcaggagga cggtgtcggc tacagcatca
     5101 ccgacaccat cgtcagcgcc gggacccgct cccgcctgga gtaccgcaac cacctggagt
     5161 cctgctactg catcgagggg tcgggggccg tcatcgagct ggacggcacc gtccacccgc
     5221 tccgccccgg gcggatgtac tccctcgaca agcacgacgc gcatttcctg gtggccgacc
     5281 ccgacaccga cctgcggctg gtgtgcgtct tcaccccggc tctgcagggc gacgaggccc
     5341 accgcctcga cgagtccctc gcctcggcgt actgaggacc ggcgtgttcg aggcgaccac
     5401 cgaggccgcg gagctgcgca agggcctggc cgactgggcg aaggacctca gcgagggcca
     5461 catcgaggcc gacgaggcag gggagttccc ctggcacaag tggcggatga tccagcggag
     5521 cggtctgctc gggctgccgt tcgcgcagcc gtggggcggc ctggagcgct cgctgcccga
     5581 agtcctccac gtgctggagg ggctgggcga gtactgccgc gactccgggc tgagcttctg
     5641 cgccacgacg acgatggcca gcaccggcgt ccccgtggag cggttcggca cggcggagca
     5701 gcaaaaacgg tatctgcccg gaatctgctc gggcgagctg atcggggcgc acgccatcac
     5761 cgaatccgag agcggctccg acgcgctgcg gatggccacg cgggccgaac ccgacggcga
     5821 cggcttcgtg ctgcacggca gcaagctctt cgtcaccaac gcaccgatcg ccgacgtgtt
     5881 cgtcgtctac gcgcgcaccc accccgacgg cggtccgctg ggtacgacgg cgttcctggt
     5941 ggaccgcgac acaccgggcc tgacgtgcgg tgccccggcc aggaagatgg ggctgcgcac
     6001 cgctccgatg tcggagctgt cgctggacgg cgtccgcgtc gcccgggacc gggtggtggg
     6061 ccgggtcggc ggcggattcc tggtgatgga ccacgtgatg aagcgggaga tcctcttcac
     6121 cgccgccgtg cacgcgggcg agatggaaca ccggctccag cggtgcctgg actacgcgaa
     6181 gagccggcac gccttcggtc ggccgatcgg ttcgtaccag tcggtcacca accgcatcgc
     6241 cgagatgcgg atccgcctcg atacggcccg caagtggatc ttcgacaccg gggagcgcct
     6301 cgcggcgggc cacgacgtca cagtcgatct cgccgcgacc aagctcgtga ccagcgaggc
     6361 gaacgtggcc ggcagtctgg ccgccgtcgc catcttcggc ggccacggct acatggtcga
     6421 gcaggggatg gagaaggagg tccgcaacgc cgtgggcggg accgtctatt cgggaacgag
     6481 cgacatccac tacaaccgca tcgccgcggc gctggggctg gatccgtgag tgcgcgacac
     6541 cccggcccgc cggcggcggg cgggccgggg accctcctca aggcctgcgg ggcagtgtcg
     6601 gcgcgggagg tcgcggccgc ggccgccggc ggcgccgact gcgtggggct ctggcacggg
     6661 attcccggcg gccgcgcgga actcgccgag cacacggcga gggggttggc ggccgaggcc
     6721 cgctcgcacg gcgtggaacc ggtcctggtc accttcggcg acgacccggc ggcgctggcg
     6781 gccgccgccg accgcaccgg ggtgcggtgg gtgcagctgc acgcctacca gctcccgcgg
     6841 gtggtgggcg gtctgcgcga gagggcaccc ggcgccgtcc cggtcaaggt gctgcacgtg
     6901 gacggcggcg ggcggtgcct ggagctgcgg ctggccgacg cctatgcccg ggccgggacc
     6961 gagatgttcc tcctcgacac cgcgaccgcc gacggacggg tcggcagtac gggccaggcg
     7021 ctggacgcgg tcggcgtgct gcgcatcgcc gaccggctgc ccaggccctt cctgctggcc
     7081 ggaggcgtca ccgcggcccg ccgggcggac tacgaccgcg tcgtcgagca ccccatgttc
     7141 gccggggtgg acgtcgacac cggcgcccgg ggcggggacg gggaactgtc cgaaaccgcg
     7201 gtaaccgaac tctcccgcgc ctggcggacg gggcgcgggc gacgaaagga gcgcagctga
     7261 tggcgcacga cttcatcgac gccctgctcg gtgccgagcg gccggtgatc gccgagatca
     7321 agcgcaggga ctcccacggc cgggacctct tcgcggggcg cggaccggcc gacatcgtct
     7381 ccgcctacga acaggccggg gcaccgtgcc tctcggtggt caccggatcc tggttcggcg
     7441 gcagtgaggc actgctggcc gagaccgcag agctgacacg gctgcccctg ctgcagaagg
     7501 acttcgtcac caggcgcgac cagatcaccc gggcggccga cctcggcgcc gccgcggtgc
     7561 tgatcacggc cgaactgctg ccccgcccgg cacttcagtc gctggtcgcc tcctgcctgg
     7621 acacggggct gaccccgttc gtcgaggtga ccgagcagcc ccaagcggcc gctgttccgc
     7681 acgccgagca gtgcgtgatc gcggtcaaca acaagaacat ccgcacccgg gagcgcgacg
     7741 cgggcgacac cggccgcagc ctcacgctgc tgcccgcgct gctggaggcg ggcacgcgct
     7801 gcccggtcag cgccagcgcg gtacccgacc cgcacgtcgg cgcccggctg ctggacgccg
     7861 ggttcgccgg actgctggtg ggcacggcgc tgctgcgcga cggcgatccg cggggctggc
     7921 tcgacaccgt ggcgcggcgg cggcaggtgc cgccggccca gccgcccgca ggcaccgaag
     7981 tcgcggatgc gccggccccg ctcggcgggc gaccgtgagc gcgccgccgc gcgcggcgcc
     8041 cgccggcgcc gacatccggc gcattcgcct ggacgccggt ggaatcaccc tttcggggct
     8101 gctggcgcgt cccacgggcc cgccgcggcc gggtggcgcg aaccgtccgg tcgtactggc
     8161 cgtccacggc cggtccatgc gggccgacta cttccacgcc cgcacccacc ccgacctctc
     8221 cctgctggat gtagccgtcg cccgcggaca caccgttgtg gccctggacc ggccgggcta
     8281 cggtgcatcg gccgagcggc tgcccgaggg ccagacggtc gacgagcagt cggcgaccgt
     8341 gcacgcggcc ctgcgctcgt tctccgccga ccatgcggcc cgggccggct tcgtcgtgct
     8401 cgcccactcc cacggcggca agctggccct gcggctcgcc gccgacgact ccgcgggccg
     8461 catccgcggg ctggacatat cggggtgcgg agtcgagtac tccgcggcgg cgcgcggtct
     8521 gccgtcctcc ctgggcgccg gcgcgtcgcg gctgaactgg gggccgctgc ggctctaccc
     8581 gccgggcacc ttccagcagg cgcgcagcct gctggcgccc actccgccca gggaggacgg
     8641 cgagtggctg cgctggccgc accagtaccg cgacctcgcc ccgcgggtgc gggtcccggt
     8701 gcgcttcacc ttcgccgacc acgaggcgtg gtggcggctg ggggactccg atctggccga
     8761 gctggccggg gcgctcaccg cggcgccgcg ggtgggcgtc caccgccacc ccgacgccgg
     8821 gcacaacatc agcctgggct ggagtgcgcg cgcctaccat ctgcgcgccc tcgaattcct
     8881 cgaagcgtgc cgctgaggcc gggcgccggg cgccgctaaa gtcccagtac ccggcgcagc
     8941 tcccgggcct ggcggcggga gacctcgacc cggctcttgc gggggtcgtc catcagcagc
     9001 atcagcgtgc cccggaagtc gggggccagt tcacgcacgt agtcgaggtt caccaggtag
     9061 gagcggtgcg cgcggaagaa gtgcgcaccg cgcaggcggc gctccagctc gttcagggag
     9121 aagttgacca gcacccgctc gtcggcgagc tgcaggtagg agtatccgcg cgccgctccg
     9181 gcgtagatga tcgaggactc gttgagcagc acggtccggt cgcccttgtg caccgggatg
     9241 cggtgcggcg aatccgcgcc gtcggaccgc cgcggcggct ccggctgcgg ttcgccctcc
     9301 tcggggcggg cggccagggc gcggtccagc gcccgctcca gccgctcggc gtcgaagggt
     9361 ttgaccaggt agtcggcggc gtccagatcg aacgcctcga ccgcgtagtc gggaaacgcc
     9421 gtggtgaaga tgatcctcgg cgggtgcgcc gcctcgcgca gcttgcgggc gacgtccagc
     9481 ccggtgccgc cgggcatccg gatgtccatc agcacgaggt cgtagtccag ggagtccagc
     9541 agcagcagcg cttcctcggc gttggacgcc tcgccgacca cctgaacgtg gtcgaaccgg
     9601 gacatcaggt aacggagatc cgcccgcgcc ggagcctcgt cgtcgacgat gaggcatcgc
     9661 gcgcgcatag tcatccaaag gggattcgca gatcgatgac ggtcccgccg ccctcggtgg
     9721 actggatgtc cagacgatag cgctccccgt agagcgatgc caagcgtcca gcgatattgc
     9781 tcagcccttg gccgtcgcct tcgccgcgct caccgtcgga gatgcgcttc agcaggtcgg
     9841 cggggattcc gactccgtcg tcggcgaccc ggatggaggt ggtgcgggtc agcggatcca
     9901 cccgcgcctt caacgtcacc gtgccgccct cgaccttgct cgccaacccg tgcttgatcg
     9961 cgttctccac cagcggctgg atgatgagga ccgggacgtg ggcggtgagc acctggggat
    10021 cgatgtcgta gcgcacctgc acgcgttcgc cgtagcgggc ctgttccagc gacacgtagg
    10081 tgcgcacgaa gaagtactcc tggccgaact cggcgaagtg cccctcctgg cgcaccacgt
    10141 agcggaagaa gtcggacagg cgcaccagca gctgccgtgt ctcctcggtg tcggtgtgca
    10201 ccttggatgc gatggtgttg agggtgttga acaggaagtg cgggttgatc tgggcgcgca
    10261 gcgcgtcgag cttggcgtcg accgcgagcc gctggcggcg gttgagctcg gccagctcca
    10321 ggtgcagcga gaggataccc gccaagccct ccaccacccc ctgcggcgac agcgc
//
