LOCUS       NZ_CP036455            21041 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Streptomonospora litoralis strain M2 chromosome, complete genome.
ACCESSION   NZ_CP036455
VERSION     NZ_CP036455.1
KEYWORDS    RefSeq.
SOURCE      Streptomonospora litoralis
  ORGANISM  Streptomonospora litoralis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 5724192)
  AUTHORS   Khodamoradi,S., Hahnke,R.L., Kaempfer,P., Schumann,P., Rohde,M.,
            Steinert,M., Luzhetskyy,A., Wink,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2019) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.3x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004323735.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,076
            CDSs (total)                      :: 5,002
            Genes (coding)                    :: 4,957
            CDSs (with protein)               :: 4,957
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 6 of 46
            Pseudo Genes (incomplete)         :: 39 of 46
            Pseudo Genes (internal stop)      :: 2 of 46
            Pseudo Genes (multiple problems)  :: 2 of 46
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:19:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3429253
            Orig. end                         :: 3450294
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21041
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="8"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21041
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21041
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11041](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11041)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(501..514)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.97"
                     /tool="antismash"
     misc_feature    complement(514..530)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.52"
                     /tool="antismash"
     gene            complement(1275..2318)
                     /gene="pdxA"
                     /locus_tag="EKD16_RS14600"
                     /old_locus_tag="EKD16_14985"
     CDS             complement(1275..2318)
                     /EC_number="1.1.1.262"
                     /GO_function="GO:0050570 - 4-hydroxythreonine-4-phosphate
                     dehydrogenase activity [Evidence IEA]"
                     /GO_process="GO:0008615 - pyridoxine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdxA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153480.1"
                     /locus_tag="EKD16_RS14600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_14985"
                     /product="4-hydroxythreonine-4-phosphate dehydrogenase
                     PdxA"
                     /protein_id="WP_131098891.1"
                     /transl_table=11
                     /translation="MPETAEPATGRPALAVTVGDPVGIGPEITVRTLAEIGTTASARGV
                     VVADPAVLRRAADVCGLDVRIRELHSWDLPEERDGVIDCFDLGELGEAELAWGTVDKRA
                     GAAAVRAIEVATGAAMERRVSGVVTGPINKEAIWAAGSEHLGHTEMLGALTGVTRQNTM
                     FVVRGKKIFFATRHVSLRTALDQCGTDHQVGAIEEALTALRVFGHDEPRLAVAAINPHG
                     GENGAFGTEEIDHLAPAVERVRARGSDVAGPVPADSVFHQLLQDRYDGVLSQYHDQGHI
                     AAKTFDFDGTISVTVGLPILRTSVDHGTAFDIAGTGAADPATMRSAFLHGCEFSHFADR
                     IRAEYGS"
     gene            complement(2417..3853)
                     /locus_tag="EKD16_RS14605"
                     /old_locus_tag="EKD16_14990"
     CDS             complement(2417..3853)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017599782.1"
                     /locus_tag="EKD16_RS14605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_14990"
                     /product="four-carbon acid sugar kinase family protein"
                     /protein_id="WP_131098892.1"
                     /transl_table=11
                     /translation="MAQVLVVADDLTGANATGARFARAGMRVATVTPEQAPRAARDYDA
                     VVINLDSRHVPAEQAGDLVADAVEAVWPVGLVVKRTDTTLRGNVGAELEAAWRAVRERV
                     AESVPVRALFVPAFPDSGRVTVDGVQLLDGVPLERTELALDPLNPMRTSVVGDILAAQT
                     GLAVRHVPLRRIAQGPLAAQLAAGEEPVVLCDALTEQHLADIAQAAAVVHRDDGTVWLA
                     VDPGPAGALLADALELRGRAAAAGPLLGVVGSATELTRRQLDAVARGGPVRFVDVDAAR
                     LARDGGEYRTALARELTDHLRAAAFPEPVVLRTAQSARDVVELPGAAKLALPGLLAALV
                     GDAVRRAEGPARPSGLYTSGGEVTSAVLDALEARAFEVDGEVVPLAVHGRLSGGALDQI
                     PVVTKGGLVGDDSALVECLAELRRAVRGRLRTVPAEVPEHHAPHSPHPPQTPPYSGAAE
                     PAVPAESSETAGCPRTPPRA"
     gene            complement(3864..5327)
                     /locus_tag="EKD16_RS14610"
                     /old_locus_tag="EKD16_14995"
     CDS             complement(3864..5327)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013153482.1"
                     /locus_tag="EKD16_RS14610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_14995"
                     /product="GntP family permease"
                     /protein_id="WP_131098893.1"
                     /transl_table=11
                     /translation="MDVQLLAALVLGVAAVVAIIVWSRLDAFVGLLAGALVTGVVAGVP
                     VTELIDHITTGFGNTLAGIGIVIALGVMIGKVLEESGGADALARMFVRAFGKGREDVAM
                     TATGAVVSVPVFCDSGFVILHPLARTLARRYGKPLVGVCLALAGGLAVTHHLVPPTPGP
                     LAAVGLLGADLGTVILAGVAMAAILVPVVVAYARIMGPRLERELDPDLVPELAAAGGTA
                     GAAAGGRGSGAAGTAGTATIGSAGAGAGVSKEDGESDAGEESGGKPRINPALAALPLLL
                     PLLLIVGNTVTGATAEGSRIAELFAFIGEPAIALLIGLVIAVYLLPRLHTGRKTVVGWL
                     TSAAASAGMIVFITGAGGAFGEVLRQSGVGDALAETVSQWPVPMFLMPFLIATFVRIAQ
                     GSGTVAIITAATLSAPLVQSAGVDPTLAVLSACSGSFVFSYVSDSFFWVVTRFTGLSGG
                     AAMKMWTGATTTLWLASLPLLGIAALILG"
     gene            complement(5347..6132)
                     /locus_tag="EKD16_RS14615"
                     /old_locus_tag="EKD16_15000"
     CDS             complement(5347..6132)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017540630.1"
                     /locus_tag="EKD16_RS14615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15000"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_131098894.1"
                     /transl_table=11
                     /translation="MRHQELLDAVIDGIQRVEDLARILGISPSTVRRGLAELEQAGKVV
                     RTHGGAVPSPTGGELSWTQKSRRHAAAKRRIAAYAADLVADDHVVLLDAGSTTTFIAER
                     LASRFGPTVATNGLGPMTALHDAEGVELIVLGGRVRRRRGSIVGDYARGVLDRLTADIA
                     FIGADGVVPGRGINCPSPELAAIKELQMRSAREVVVVADSSKANAAEHHYWAVAPGPHV
                     LVTDDGIGDEDARTFDADPSCRLRVVATAGDPITPAATD"
     misc_feature    6154..6167
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(6188..6202)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.32"
                     /tool="antismash"
     misc_feature    6411..6424
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.03"
                     /tool="antismash"
     gene            complement(6677..8398)
                     /locus_tag="EKD16_RS14620"
                     /old_locus_tag="EKD16_15005"
     CDS             complement(6677..8398)
                     /EC_number="2.2.1.7"
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017556344.1"
                     /locus_tag="EKD16_RS14620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15005"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase"
                     /protein_id="WP_131102570.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 2.3e-77,
                     bitscore: 258.0, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-05, bitscore:
                     23.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAADLPPLAARIRRFLIEKVSRTGGHLGPNLGAVELTIAAHRVF
                     DTTRDTLLFDTGHQTYVHKILTGRGADFDTLRKEGGLSGYPSRAESGHDLIENSHASTA
                     LSYADGLAKAVRLSGTTERRVAAVVGDGALTGGMAWEALNNIGAAPQRPVVVVLNDNGR
                     SYSPTVGGIARHLAGLRGAVGERSAGTVFEGLGLAYIGPVDGHDIAEVEDALRSAVSLH
                     RPVVVHCVTRKGKGYAPAEADESDHMHTVGVIDPATGRPAKSGATWTSVFAEEITAIGA
                     ERSDVVCVTGAMRLPAGLGPFAERFPDRVHDVGIAEQHAVTSAAGLAFGGMHPVVAVYA
                     AFLGRAFDQVLADVALHRLPVTFILDRAGVTGPDGASHHGMWDGSLLPVVPGLRLAAPR
                     DCARLRELLREAVATADGPTALRYPKSAVGSDIPAVRRIGDCDLLREAAGARVLLVSAG
                     PLAAACLEAAAELDGRGIAASVVDPRWTAPVSSALVSLAAGYDLVVAVEDTVTTGSLGM
                     RLAAELSAAGATTRVATRALPDRFLPHGSRSRILASVGLDPESIAAAVRNLLDHPG"
     misc_feature    8664..8679
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(8665..9972)
                     /locus_tag="EKD16_RS14625"
                     /old_locus_tag="EKD16_15010"
     CDS             complement(8665..9972)
                     /EC_number="1.17.7.4"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051745 - 4-hydroxy-3-methylbut-2-enyl
                     diphosphate reductase activity [Evidence IEA]"
                     /GO_process="GO:0019288 - isopentenyl diphosphate
                     biosynthetic process, methylerythritol 4-phosphate pathway
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017541260.1"
                     /locus_tag="EKD16_RS14625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15010"
                     /product="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /protein_id="WP_131098895.1"
                     /transl_table=11
                     /translation="MSDTAAPPTDPGAAHPLRPGSVLVADRLVRAHDPEIACPAAALVA
                     GDLRRRGAQPVRGTLPLAAGEGPPSAAPEGGDRHAPGFTALIPGTDPPVGLGAACAADP
                     ADAAAERAAREAVDAWLAVAGTARTVLLAAPRSFCAGVERAIEVVEQALAQRGSPVYVR
                     KQIVHNTHVVADLESRGAVFVDELDAVPEGATVVFSAHGVSPRVHQEAAERSLRVIDAT
                     CPLVTKVHTEARRYASRGDTVVLIGHAGHEEVEGTLGEAPERTVLVETPEDVAALEVAD
                     PERVSYLTQTTLATDETAAVVDALRARFPALRGPASDDICYATTNRQDALKSIAEESDL
                     VLVVGSDNSSNSVRLVELAERCGTPARLIDDTGDIRPEWLAGARTVGLTAGASAPPGLV
                     EAVITALGGLGPVTVHEREITRETIHFTLPSVVRPS"
     gene            complement(10001..11041)
                     /locus_tag="EKD16_RS14630"
                     /old_locus_tag="EKD16_15015"
     CDS             complement(10001..11041)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017607099.1"
                     /locus_tag="EKD16_RS14630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15015"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     polyprenyl transferase"
                     /protein_id="WP_131098896.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 2.7e-60, bitscore:
                     202.1, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAIEETTGGRSAAEVLAGVRDIVDPVLRATVQTLPPSPRAIAEY
                     HFGWRDERGNPVGGAGGKMFRPALALLAAETVGGRAEDAVPAAVAVELVHNFSLLHDDV
                     MDGDTTRRHRATAWSVFGVGGAILTGDALLSLAFDALAAGSGHTPPEAAHRLNEAVQRL
                     IDGQSADMDFERRTDVGPAECRSMAEAKTGALLGGACGLGAAFGGTTPQGAEDMRRFGE
                     LLGLAFQIADDLLGIWGDPAVTGKPVHSDLRNRKKTLPVVAALAAGAAESGELAALFAR
                     ERSLEGPDLVRAAELVERAGGRDWGERETEALLERSLEHLRAAAAAASPAAELAALARL
                     ATRRDH"
     gene            complement(11073..12467)
                     /locus_tag="EKD16_RS14635"
                     /old_locus_tag="EKD16_15020"
     CDS             complement(11073..12467)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017619263.1"
                     /locus_tag="EKD16_RS14635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15020"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_131098897.1"
                     /transl_table=11
                     /translation="MTESSVENPQSEQLSLGTAAARNLATTTKTPPQMQGITSRWLLRV
                     LPWVQVDGGTYRVNRRLTYTVGDGRVSFITTGSDVRVVPPELAELPALRGFADEAALAA
                     LAERFEQREHGPGDVIAAAGAPVDHVYLMAHGKAGVHRAGEYGDDTVVGLLVDGDHFGD
                     SAMDADPGTWEDTVKARTACTVLALPRSAFQQAADASPALRAHLEGARARSEYPVNRYG
                     EADIAVASGHAGEPDLPGTFVDYELSPREYELSVAQTVLRVHTRVADLYNQPMSQLEEQ
                     VRLTVEALRERQEHELVNNSDFGLLHNADLKQRIPTRTGPPTPDDLDELVSRRRRTRFI
                     LAHPRAIAAFGRECSRRGVYPDSLAHEGHSVTGWRGIPMLPCDKIPVTARGTSSIIAMR
                     TGEDDQGVVGLHHIGLPDEYQPGLSVRFMGIDDKAIMSYLVSTYYSAAVLVPDALGVLE
                     NVEIGR"
     gene            complement(12729..14129)
                     /locus_tag="EKD16_RS14640"
                     /old_locus_tag="EKD16_15025"
     CDS             complement(12729..14129)
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017595267.1"
                     /locus_tag="EKD16_RS14640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15025"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_131098898.1"
                     /transl_table=11
                     /translation="MTESGVENGQQPLSLGTAAARNLATTTKTPPQMQGITSRWLLRLL
                     PWIEATGGSYRVNRRLTYTVGDGRVSFITAGTDVRVIPRELCELSLLRDFGDEAALEAL
                     AERFTQEEYAPGDVIVERGAPADRVYLIAHGKVNRLGSGEYGDETVLGTMIDGDHFGSA
                     ALVQQEGSWDATAKAVTPCTVLWLPRSEFQQVADRSDALRAHVAEVHARPAREEDPGGE
                     AAIAVASGHAGEPDLPGTFVDYEAAPREYELSVAQTVLRVHTRVADLYNQPMSQLEEQV
                     RLTVEALRERQEHELVNNSDFGLLHNADLKQRIPTRTGPPTPDDLDELLGTVWKDPSFL
                     IAHPRAIAAFGRECSRRGVYPQNVDVEGHRVPAWRGVPIFPCNKIPVTSTRSTAIMVMR
                     AGQEKQGVVGLHQTGLPDEYQPGLSVRFMGIDDKAIMSYLVSTYYSAAVLVPDALGILE
                     NVEIGREG"
     misc_feature    complement(14175..14190)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.37"
                     /tool="antismash"
     misc_feature    14285..14300
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.7"
                     /tool="antismash"
     misc_feature    14553..14567
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.93"
                     /tool="antismash"
     misc_feature    complement(14728..14741)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.86"
                     /tool="antismash"
     misc_feature    complement(14728..14742)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.76"
                     /tool="antismash"
     misc_feature    complement(14730..14743)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 12.77"
                     /tool="antismash"
     misc_feature    complement(14733..14742)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.0"
                     /tool="antismash"
     misc_feature    complement(14757..14766)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 15.86"
                     /tool="antismash"
     gene            complement(14896..16776)
                     /locus_tag="EKD16_RS14645"
                     /old_locus_tag="EKD16_15030"
     CDS             complement(14896..16776)
                     /EC_number="2.2.1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004559.0"
                     /locus_tag="EKD16_RS14645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15030"
                     /product="transketolase"
                     /protein_id="WP_131098899.1"
                     /transl_table=11
                     /translation="MRRKDTMTDRQRLKELGQQLRVDAVRAADAAGSGHPTSSMSAADL
                     MAVLASGHLRYDFDAPEHAGNDHLIFSKGHASPLLYSLYKACGVISDAELLRYRRLGSP
                     LEGHPTPRLPWVDVATGSLGQGLPIGAGVALAGTSLDRLPYRVWVLCGDSELAEGSVWE
                     SFEYAGQARLANLTAILDINRLGQRGPTRHGWDLDAYRRRVEAFGWHTVEIDGHDVEQI
                     DAAYREAAETTDRPTAIIARTVKGAGVSAVADQEGAHGKPVPDAEEAISELGGTRDMRI
                     EVAAPTSGGVRQRPGGAAVDLPTFDVGEEAATRDAFGQAVTAAGTARDDVVVLDGEVAD
                     STRAKFFAAEHPERFFEFYIAEQQMIAAAVGLQVRGWTPYAATFAAFLTRAYDFIRMAA
                     VSRADINLVGSHAGVSIGEDGPSQMGLEDMAALRAVHNSVVLHPCDANSSARLTAGMAE
                     HDGVSYLRTMRGKTPVLYGPDEGFEIGGSKVLRSSGADEVTVVGAGATVHEALAAADKL
                     AGEGVAVRVIDAYSVKPVDAPTLRAAAEETGRIVTVEDHWPEGGLGDAVLDVFADTRSR
                     PRTMKLAVSHMPASAAPDEQRREAGIDAGAIEAAVRGILRQEETPAAAGA"
     gene            complement(16812..18008)
                     /locus_tag="EKD16_RS14650"
                     /old_locus_tag="EKD16_15035"
     CDS             complement(16812..18008)
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019608791.1"
                     /locus_tag="EKD16_RS14650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15035"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_131098900.1"
                     /transl_table=11
                     /translation="MPTAQTGTRPAAGVPTMGVEEEFFLVGADGRLAPRSVEVLDAAPP
                     GPGELLGEFTRSQVEAAGPVCAGAGELLAGLRESRRRLAEAAARLDTRVIAGAVPVMAE
                     LGPQQLNPGTRYHRIAERFGAVAEAAGTNCGCHVHVEVPDRDSGVQAGNRLRAWLPTLL
                     ALSANSPVCGGTDTGYGSWRQPRWSRWPTAGPPPPMESAEHYEHCVAALLESGAALDRR
                     MLYWDIRLSDRHPTVEIRVCDVPATPEESALIAVLVRALVAAALDDAAQGRPAPRRDPA
                     VLRGDLWRAARDGLEGSCPDPLNGGRLRPVHGVLAGAVEHLRPYLERSGDLGFAQAVLT
                     ALRAHGGGAARQRVSFNRRSLAADVVDDLAYATAHGLEASVTPPGRGAASAHARPFGG"
     gene            18318..18956
                     /locus_tag="EKD16_RS14655"
                     /old_locus_tag="EKD16_15040"
     CDS             18318..18956
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017615690.1"
                     /locus_tag="EKD16_RS14655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15040"
                     /product="phosphoribosyltransferase"
                     /protein_id="WP_207391304.1"
                     /transl_table=11
                     /translation="MQVFRDRDDAGEQLAERVRELGLADPVILALPRGGVPVGYVVAEQ
                     LGAPLDVTVVRKIATPDFPETAVGAVTAEGAPILNEGLSRMVRADDDELARSAEDERAE
                     ARRRVKIYRGDRPAPRVAGRDVVVVDDGLATGMSARAALSALGEEGAASLTLAVPVCSP
                     DAARALEDVCDRVVCVHSPPEFHAVSLWYERFPQTEDTEVQELLRRAGV"
     misc_feature    complement(18358..18372)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            complement(19107..19382)
                     /locus_tag="EKD16_RS14660"
                     /old_locus_tag="EKD16_15045"
     CDS             complement(19107..19382)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039758.4"
                     /locus_tag="EKD16_RS14660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_15045"
                     /product="DUF6411 family protein"
                     /protein_id="WP_242676977.1"
                     /transl_table=11
                     /translation="MHLGAPEMGPSMWIAVVIVAAAVLLVLAFLLPRLSRGPERGGKRL
                     LGIPKIGTRKLPGRIGHYASKPFSQSQRVLGKSGRAGRKGRGKSPM"
     misc_feature    complement(19533..19544)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.34"
                     /tool="antismash"
     misc_feature    complement(19552..19567)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.22"
                     /tool="antismash"
     misc_feature    complement(19896..19911)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.02"
                     /tool="antismash"
     misc_feature    complement(20203..20217)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.26"
                     /tool="antismash"
     misc_feature    20718..20731
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
ORIGIN
        1 tgcagtacta ggacggcaga gggccggacc tgcggtgaac gagtcgggtg ctcgccggtg
       61 gcggtgatcg gcggagggcg gcaggggtct gctgtgcggc cttgtgaact gccgggcgac
      121 gggtggactt caccggaaag cagcagcaag ggcggcgaat ggtggaggcg gcggccatcg
      181 cacccggtgc ccgccggtcg ggcgccagac gcgagcggca cgggtccgct tggcggcctt
      241 gctggcctgc cgggcgacgg gcggtcttca ctcaaaagcg gcggcggtgg cagccgagcc
      301 gggcccgcgc ccaccgcacc gcatgcccgc cggtggccca cccggcgggg gcggcggggc
      361 cgagcccgcg gtagtcggcg gcgtccatgc agccgggtcg gggccacgag acgcacgtac
      421 gtgcggcggc acccgcctcg gcgccgcccc gaggcgccac ccacgcaccg tgattccgcg
      481 atacgaaaca acgcggggcg ttttgtccag caatgcccga tttcccagcg ggcccgcagc
      541 cgcgctgcgg cggcggtggc gcacgaggcg caccgaatgg cgcgaaaacg cccctgacgt
      601 cgacttttcg tgcacctcgt cgccaccgcg cccgccgagg ccgcccgcaa aacgggcata
      661 ggaccccaaa agcccacccc atcgggtcgt ggagctcccg gcggccgccc ccgggcgcca
      721 cgagcgacgt gtcgtcgccc ccgggccccg atccggcgcg gccaccgggc cgtgcgggca
      781 cccgcgaccg cgccccgccg cgcggctgcc tgcccgcgcg ggcccggccg gaacacggcg
      841 gcgacgcctc cccgcccccg cgcccgctac gtccgacgtt ccggagtcgg ccgcggagcc
      901 cgcggcgatc gcggccgaat tcccacaaaa cgccgctgga tctcgtcata cgggcacaat
      961 cgccgcgccg ccctgcgaca tagcgggcac gcgagcgcct cccggctccc ccgcgccctc
     1021 gccgaccccg tcgcgtgggt caccggcggg tacctggccc attgggcgcg ggctgggccc
     1081 tccgccaccg tcgccgccgc ttttcccgaa gaccacccgc accccggcag accaacaagg
     1141 ccgcacagca gacccgagcc gcccgccgcc gaccgccgcc accggcaagc acccgacccg
     1201 gcgccggcta gcgaggcggc gccgcggcgg tcacagcgtc gcgggagcca cggcggggcg
     1261 gcgcggcatc gccgtcagga accgtactcg gcgcggatgc ggtcggcgaa gtgggagaac
     1321 tcgcagccgt gcaggaacgc cgagcgcatc gtggcggggt cggcggcgcc ggtgccggcg
     1381 atgtcgaagg cggtgccgtg gtcgaccgag gtgcgcagga tcggcagtcc caccgtgacc
     1441 gagatggtgc cgtcgaagtc gaaggtcttc gcggcgatgt ggccctggtc gtggtactgg
     1501 gagaggaccc cgtcgtagcg gtcctgcagc agttggtgga agaccgagtc ggcgggcacc
     1561 ggtccggcga cgtcggatcc ccgggcgcgc acccgctcca cggcaggggc gaggtggtcg
     1621 atctcctcgg tgccgaaggc gccgttctcg ccgccgtggg ggttgatggc ggcaacggcc
     1681 aggcggggct cgtcgtggcc gaagacccgc agcgcggtca gcgcctcctc gatcgcgccg
     1741 acctggtggt cggttccgca ctggtccagc gccgtgcgca gcgagacgtg gcgggtggcg
     1801 aagaagatct tcttgccgcg caccacgaac atggtgttct gccgggtgac gccggtgagc
     1861 gcgcccagca tctcggtgtg gccgaggtgc tcgcttccgg ccgcccagat cgcctcctta
     1921 ttgatggggc cggtgacgac cccggagacg cggcgctcca tggccgcgcc ggtggcgacc
     1981 tcgatcgcgc gcacggcggc ggcgccggcc cgcttgtcca cggtccccca ggcgagctcg
     2041 gcctcgccca gctcgcccag gtcgaagcag tcgatcacac cgtctcgctc ttccggcaga
     2101 tcccaggagt gcagttcgcg gatgcgcacg tccaggccgc acacgtcggc ggcgcggcgc
     2161 agcaccgccg ggtcggccac caccacgccg cgggcggagg cggtcgtgcc gatctcggcc
     2221 agagtgcgga cggtgatctc ggggccgatg cccaccgggt ctccgacggt gacggcgagg
     2281 gccgggcgtc cggtggcggg ttcggcggtc tcgggcatct cttttccctc ccaggaagcg
     2341 ggtccggccg cggcgagggc ggtcggacgg gtgtcgctgc tcgtcgcgcg gcgccggtcg
     2401 gcggccgctg acggggtcag gcccgcggcg gtgtgcgcgg gcatccggcg gtttcggagg
     2461 actcggcggg cacggcgggc tcggcggctc cggaataagg cggggtctgc ggcggatggg
     2521 gcgagtgcgg ggcgtggtgc tcgggcacct cggccggaac cgtgcgcagg cgcccccgca
     2581 cggcgcggcg cagctcggcc aggcactcca ccagtgcgga gtcgtcgccg accaggccgc
     2641 ccttggtgac gacggggatc tggtcgaggg cgccgccgct gaggcggccg tgcacggcga
     2701 gcgggacgac ctcgccgtcc acctcgaacg cgcgcgcctc cagggcgtcc aggacggccg
     2761 aggtcacctc gccgccgctg gtgtagaggc cgctgggccg ggccgggccc tcggctcggc
     2821 gcaccgcatc gccgaccagg gcggccagca ggccgggcag ggcgagcttg gccgccccgg
     2881 gcagctcgac gacgtcgcgg gcggactgtg cggtgcgcag tacgaccggt tcggggaagg
     2941 cggccgcccg gaggtggtcg gtgagttccc gggccagcgc ggtgcggtac tcgccaccgt
     3001 cccgggccag gcgggcggcg tcgacgtcga cgaaacgcac cggcccgccg cgggcgaccg
     3061 cgtcgagctg gcggcgggtc agctcggtcg cgctgcccac gacccccagc agcggtccgg
     3121 ctgctgcggc gcgcccgcgc agctccagtg cgtcggccag cagcgccccg gcggggccgg
     3181 ggtcgacggc gagccacacc gtcccgtcgt cgcggtggac gactgcggcg gcctgggcga
     3241 tgtcggccag gtgctgctcg gtgagcgcgt cgcagagcac gacgggctcc tcaccggcgg
     3301 ccaactgggc ggcgagcgga ccctgggcga tgcggcgcag cgggacgtgc cgcaccgcca
     3361 gcccggtttg ggcggcgaga atgtcgccca cgacgctggt gcgcatcggg ttgagcgggt
     3421 ccagggccag ctccgtgcgc tccagcggga ctccgtcgag cagttgcacg ccgtcgacgg
     3481 tgacacgtcc ggagtcgggg aaggccggta cgaacagggc gcgcaccggc acggactccg
     3541 ccacgcgctc gcgcacggcc cgccacgccg cctccagttc cgcgccgacg ttgccccgca
     3601 gggtggtgtc ggtgcgcttg accaccaggc caaccggcca gaccgcctcc accgcgtcgg
     3661 cgaccaggtc gccggcctgc tcggcgggga cgtggcggct gtcgaggttg atcaccacgg
     3721 cgtcgtagtc gcgggccgcg cgcggcgcct gctcgggagt gaccgtggcc acacgcatcc
     3781 ccgcgcgggc gaaccgggcg ccggtcgcgt tggcgccggt gaggtcgtcg gcgacgacga
     3841 gtacctgggc cacggtcgtc ctcctatccc agaatcagcg cggcgatgcc cagcagcggg
     3901 aggctggcaa gccacagggt ggtggtggcg ccggtccaca tcttcatcgc cgcccctccg
     3961 gagagaccgg tgaagcgggt cacgacccag aagaacgagt cgctgacgta ggagaagacg
     4021 aaggagccgg agcaggccga gagcaccgcg agcgtcgggt cgaccccggc cgactgcacc
     4081 agcggtgcgc tcagtgtggc ggcggtgatg atggcgacgg tgcccgaccc ctgggcgatg
     4141 cgcacgaacg tggcgatgag gaacggcatc aggaacatcg ggaccggcca ctgcgacacc
     4201 gtctcggcga gggcgtcgcc gacacccgac tggcgcagca cttcgccgaa cgcgccgccg
     4261 gcaccggtga tgaacacgat catgccggcg gaggcggccg ccgaggtgag ccagccgacc
     4321 accgtcttgc ggccggtgtg cagccgcggc agcaggtaca cggcgatgac caggccgatg
     4381 agcagtgcga tggcgggctc gccgatgaac gcgaacagct cggcgatgcg gctgccctcg
     4441 gcggtggcac cggtgacggt gttgcccacg atgagcagca gcggcaggag cagcggaagc
     4501 gcggccaggg ccggattgat ccgcggtttg ccgccggact cctcccccgc gtccgactcc
     4561 ccgtcttcct tggagacgcc tgcgccggcg ccggccgagc cgatggtggc cgtgccggcg
     4621 gttcccgccg cgcccgagcc gcggccgccg gcggccgccc ccgcggtgcc gccggcggcg
     4681 gcgagctcgg gcacgaggtc ggggtccaac tcgcgctcca ggcgcggccc catgatgcgg
     4741 gcgtaggcga ccacgaccgg caccaggatg gcggccatgg ccactccggc caggatcacg
     4801 gttcccaggt ccgcgccgag cagccccacg gcggccagcg ggccgggcgt cggggggacg
     4861 aggtggtggg tgacggccag gccgccggcc agcgccaggc aaaccccgac gagcggcttg
     4921 ccgtagcggc gcgccagggt acgcgccaac gggtggagga tgacgaagcc ggagtcgcag
     4981 aagaccggaa cggacacgac ggccccggtc gccgtcatgg cgacgtcctc gcggcccttg
     5041 ccgaaagcgc ggacgaacat ccgggcgagc gcgtcggcgc cgccgctctc ctccagcacc
     5101 ttgccgatca tgacgccgag tgcgatgacg atgccgatcc cggcgagggt gttgccgaag
     5161 ccggtggtga tgtggtcgat cagctcggtt accgggaccc cggcgaccac gccggtgacc
     5221 agcgcgccgg ccagcaggcc gacgaaggcg tccagccgcg accatacgat gatcgcgacc
     5281 acggccgcga cgccgaggac cagcgccgcg agcagctgca catccatgtc cgcccctttc
     5341 gtggggtcaa tcggtcgccg caggcgtgat ggggtcgcct gcggtcgcga cgacgcggag
     5401 tcggcaggag gggtccgcgt cgaaggtgcg ggcgtcctcg tcaccgattc cgtcgtcggt
     5461 gaccaggaca tgggggccgg gcgcaacggc ccagtagtgg tgttcggccg cgttggcctt
     5521 gctggagtcg gcgaccacca cgacctcgcg ggcgctgcgc atctgcagct ccttgatcgc
     5581 cgcaagttcg gggctggggc agttgatccc gcgaccgggg accaccccgt cggcgccgat
     5641 gaaggcgatg tcggcggtga gccggtcgag cacgccgcgg gcgtagtcgc ccacgatgga
     5701 tccccggcgc cgccgcacac ggccgccgag cacgatcagc tcgacgcctt cggcgtcgtg
     5761 cagggcggtc atcggaccga gcccgttcgt ggcgaccgtg ggcccgaagc gggaggccag
     5821 gcgctcggcg atgaaggtgg tcgtgctgcc cgcatcgagc aggaccacgt ggtcgtcggc
     5881 gaccaggtcg gcggcatagg ccgcgatacg ccgcttggcg gccgcgtggc gccggctctt
     5941 ctgcgtccag gacagctccc cgccggtggg cgagggcacc gcgccgccgt gggtgcgcac
     6001 gactttgccg gcctgttcca gctcggccag tccccgccgc accgtggagg ggctgatgcc
     6061 caggatccga gccaggtctt cgacccgctg gatgccgtcg atgacggcgt ccagcagctc
     6121 ctgatggcgc actgcacact cccggctgct catttcacgc agatgaacag cccaagaatg
     6181 actcagatgc tcatattaag caacctgtaa gcccgatcgt gactgaaaca cgcaaagcac
     6241 tgaaagctgc acgctctggg ggcgggcgcg cggtcgtcgg gcggggtgcc cggcggtggc
     6301 ccagccggct gaggggcggc tcgggtctgc tgttcggcct tgtcggtgga gcgcccggcc
     6361 tcggtgtcgc tgtgctcgtc caacgcccgg aaatcaccaa atccgagtcg ttctttggcg
     6421 aaaacctcgc gctcggcggc cggatgaacc ggcggaccgg acatatcggc gccggccacc
     6481 ctcgcacgag ccaccgcccg cggccagcac ccggacttcc cttcgccgac ggccgccacc
     6541 ggcgggcacc cggcccgaca accgcaggcg caacccaccg ccgccctcgc cgccgctctc
     6601 cagtaaagac cacccgccac ccggcagacc accaaggccg cccagcaaac ccgagccgcc
     6661 cccgcaccgc accctttcag cccgggtggt ccagcaggtt ccggacggcg gctgcgatgc
     6721 tttccgggtc gaggccgacc gacgcgagga ttcggctgcg ggatccgtgc ggcaggaacc
     6781 ggtccggcag ggctcgggtg gcgacgcggg tggttgcgcc cgccgcggag agctccgcgg
     6841 ccaggcgcat gcccagcgag cccgtggtca ccgtgtcctc gaccgcgacg acgaggtcgt
     6901 atccggcggc gagggagacc agcgcggagg agaccggggc cgtccaccgc gggtcgacca
     6961 cgctcgcggc gatcccccgc ccgtccaact cggcggccgc ctccaggcag gcggcggcca
     7021 acgggcccgc cgacaccagc aggacccggg cacccgccgc ctcgcgcagc aggtcgcagt
     7081 cgccgatgcg gcgcacggcc gggatgtcgg aacccaccgc ggacttggga tagcgcagcg
     7141 ccgtggggcc gtccgccgtc gccaccgcct cccggagcag ttcccgcagg cgggcgcagt
     7201 cgcggggagc ggccaggcgc aacccgggca ccaccgggag cagcgaaccg tcccacatgc
     7261 cgtggtggct ggccccgtcg gggccggtca ccccggcgcg gtccaggatg aacgtgaccg
     7321 gcaggcggtg cagcgcgacg tcggccagca cctggtcgaa ggcgcgcccc agaaacgccg
     7381 cgtagacggc gaccactggg tgcataccgc cgaaggcgag tccggccgcc gatgtgacgg
     7441 cgtgctgctc ggcgataccg acgtcgtgga cacggtcggg gaatcgctcc gcgaacgggc
     7501 cgagcccggc gggcagccgc atcgcgcccg tcacgcagac cacgtccgag cgctcggcgc
     7561 cgatcgcggt gatctcctcg gcgaagaccg aggtccaggt ggcaccactc ttggccggcc
     7621 gccccgtcgc cgggtcgatg acgccgacgg tgtgcatgtg gtcgctctcg tcggcctcgg
     7681 cgggcgcgta ccctttgccc ttgcgggtca cgcagtggac cacgaccggc cggtgcagcg
     7741 agaccgccga gcgcagcgcg tcctcgacct cggcgatgtc gtgaccgtcg accggaccga
     7801 tgtaggccag ccccaggccc tcgaagaccg tgccggcgga ccgctccccc accgcgccac
     7861 gcagcccggc caggtggcgg gcgataccgc cgacggtggg cgagtaggag cggccgttgt
     7921 cgttgagcac gacgacgacg ggccgctgcg gcgcggcgcc gatgttgttc agcgcctccc
     7981 aggccatgcc gcccgtcagc gcgccgtcgc cgacgaccgc ggccacgcgc cgctcggtgg
     8041 tgccgctgag ccgaacggcc ttggcgaggc cgtcggcgta ggacagcgcg gtggaggcgt
     8101 gggagttctc gatcaggtcg tggccggact cggcgcgcga ggggtagccg gacagtcctc
     8161 cttccttgcg gagcgtgtcg aagtccgcgc cgcgtccggt gaggatcttg tgcacgtagg
     8221 tctggtggcc ggtgtcgaaa agcagggtgt cgcgcgtggt gtcgaagacg cggtgcgcgg
     8281 cgatggtgag ctccacggcg cccaggttcg ggccgaggtg cccaccggtg cgcgagacct
     8341 tctcgatgag gaaacgccgg atccgcgccg ccaggggcgg gaggtccgcg gccgccatgg
     8401 cgcgcaggtc ggccggcgac ctgatggtgt ccagcgggtc cgccccgccc tcggcgccgt
     8461 cggccccgcc cgcgtcgggg acgccggagg cgtcggcggc gggcttcgcg ctgcgaagac
     8521 cacggtcgcg accgccgctc gggctgaagc cgccctcacg gacgcctccg ctaccgcggg
     8581 cgggtgcgcc gccgccgggg tcggactgcg gctccgctgc gggcgccgcc gctgcggtgt
     8641 ttgccggatc cgtggaagcc ctggtcacga cggcctcacc accgaaggca gggtgaagtg
     8701 gatggtctcg cgggtgatct cgcgttcgtg cacggtcacc gggcccaggc cgccgagcgc
     8761 ggtgatcacg gcctcgacca gccccggcgg cgccgaagcc ccggcggtga ggccgacggt
     8821 acgggccccg gccagccact ccggccggat gtcgccggtg tcgtcgatga gccgggccgg
     8881 agtgccgcag cgctcggcga gttcgaccag ccgcaccgaa ttggaggagt tgtccgagcc
     8941 gaccaccagg accaggtcgg actcctcggc aatggatttc agggcgtcct ggcggttggt
     9001 tgtggcatag cagatgtcgt cggatgcggg cccgcgcagg gcggggaacc gcgcacgcag
     9061 ggcgtcgacg accgcggcgg tctcgtcggt ggccagcgtg gtctgggtga ggtaggagac
     9121 gcgttcgggg tcggcgacct ccagcgcggc gacgtcctcg ggggtctcga ccaggacggt
     9181 gcgttccggc gcctcgccga gggtgccctc gacctcctcg tgtccggcgt ggccgatcag
     9241 caccaccgtg tcgccgcggg aggcgtagcg gcgggcctcg gtgtgcacct tggtcaccag
     9301 cgggcaggtg gcgtcgatga cccgcagact ccgctcggcc gcctcctggt gcacccgggg
     9361 cgatacgccg tgagcggaga acaccaccgt ggcgccttcg ggcaccgcgt ccagctcgtc
     9421 gacgaaaacc gcgccccgcg actccaggtc ggcgacgaca tgggtgttgt gcacgatctg
     9481 cttgcggacg tagacggggc tgccgcgctg cgccagcgcc tgctcgacga cctcgatggc
     9541 gcgctcgacc ccggcgcaga acgacctcgg cgcggcgagc aggacggtgc gcgcggtgcc
     9601 ggcgaccgcc agccaggcgt cgacggcctc gcgcgccgcg cgttcggcgg ctgcatccgc
     9661 cgggtccgcg gcgcaggcgg cgcccagacc gacgggcggg tcggttcccg gtatcagagc
     9721 ggtgaaccca ggagcgtgcc ggtcgccgcc ttcgggggcg gccgatggtg ggccctcgcc
     9781 cgcggccagc ggcagggtgc cgcgcacggg ctgcgcaccg cggcggcgga ggtcgccggc
     9841 gacgagggcg gccgccgggc atgcgatctc gggatcgtgc gcgcggacga ggcggtcggc
     9901 gaccaggacg gagcccggcc gcagcgggtg cgcggcgccg gggtccgtgg gcggtgctgc
     9961 ggtgtcggac attgctctgc ctcctcggat cggccgtcgg tcagtggtcg cgtcgggtgg
    10021 ccaggcgggc gagtgcggcc agttcggccg cgggggacgc ggcggcggcc gcggcgcgca
    10081 ggtgctccag cgaccgctcc agcagagcct cggtctcccg ctcgccccag tcgcgtccgc
    10141 ccgcccgttc caccagttcg gcggcgcgga cgaggtcggg gccctccagc gaccgttcgc
    10201 gggcgaacag ggccgccagt tcgccggact cggcggcgcc ggcggccagc gcggccacga
    10261 ccggcagcgt cttcttgcgg ttgcgcagat cggagtggac gggtttgccg gtgactgcgg
    10321 ggtcgcccca gatgcccagc aggtcgtcgg cgatctggaa ggcgaggccg agcagttcgc
    10381 cgaatcggcg catgtcctcg gccccctgcg gtgtagtgcc gccgaacgcg gcccccaggc
    10441 cgcaggctcc gcccagcagc gcgccggtct tggcctcggc catggaccgg cactcggccg
    10501 gtccgacgtc ggtgcggcgc tcgaagtcca tgtctgcgct ctggccgtcg atgaggcgct
    10561 ggaccgcctc gttgagccgg tgcgccgcct ccggcggggt gtggccgctg ccggcggcca
    10621 gcgcgtcgaa ggccagggag agcagcgcgt cgccggtgag gatggcgccg ccgacaccga
    10681 agacgctcca ggctgtggcg cggtgtctgc gggtggtgtc gccgtccatg acgtcgtcgt
    10741 gcagcagcga gaaattgtgc accagttcga cggccacggc ggccggcacc gcgtcttcgg
    10801 cacggccgcc gacggtttcg gccgccagca gggcgagcgc gggccggaac atcttcccgc
    10861 ccgcgccgcc caccgggttc ccgcgctcgt cgcgccaacc gaagtggtat tcggcgatcg
    10921 ccctcggcga agggggaagc gtctgaaccg tcgcgcgcaa gacggggtcg acgatgtcgc
    10981 ggacaccggc gagcacctcg gccgccgagc ggcctcccgt cgtctcctcg attgccacca
    11041 tgagccggaa tcccttctgt gcgttccgtc ggtcagcggc cgatctcgac gttctccagg
    11101 actccgaggg cgtcggggac cagcacggcg gcggagtagt aggtgctgac caggtaggac
    11161 atgatcgcct tatcgtcgat gcccatgaac cgcaccgaca gccccggctg gtactcgtcg
    11221 ggcagcccga tgtggtgcag gccgaccacc ccctggtcgt cttcgccggt gcgcatggcg
    11281 atgatggagc tggtgccgcg ggcggtgacc gggatcttgt cgcagggcag catggggatg
    11341 ccgcgccagc cggtgacgct gtgcccctcg tgggccaggc tgtcggggta gacgccgcgg
    11401 cggctgcact cgcggccgaa ggcggcgatc gcgcgcggat gcgccaggat gaaccgtgtc
    11461 ctgcgccgcc gggagacgag ttcgtcgagg tcgtcggggg tgggcgggcc ggtacgggtg
    11521 gggatgcgct gcttgaggtc ggcgttgtgc agcaacccga agtcgctgtt gttgaccagc
    11581 tcgtgctcct ggcgctcccg cagcgcctcg accgtcagcc ggacctgctc ctccagctgg
    11641 ctcatcggct ggttgtacag atcggccacc cgcgtatgca cccgcagcac cgtctgcgcc
    11701 acactcagct cgtactcccg cggtgagagc tcgtagtcga cgaacgtgcc cggcaggtcc
    11761 ggctcgccgg catggccgga cgcgacggcg atgtcggcct cgccgtacct gttgacgggg
    11821 tactccgacc gggcgcgggc gccttcgaga tgggcgcgca gggcgggtga ggcgtcggcg
    11881 gcctgctgga acgccgagcg cggcagggcc aggacggtgc aggccgtgcg ggccttgacg
    11941 gtgtcctccc acgtgccggg atcggcgtcc atcgcggagt cgccgaagtg gtcgccgtcg
    12001 acgagcaggc cgaccacggt gtcgtcgccg tactcaccgg cccggtgcac gcccgccttg
    12061 ccgtgggcca tgaggtagac gtggtcgacg ggggcgcccg cggcggcgat gacgtcgccg
    12121 ggaccgtgtt cacgctgctc gaagcgctcg gccagggccg cgagcgcggc ctcgtcggcg
    12181 aagccgcgca gcgccgggag ttcggccagt tccggcggga cgacgcgcac gtcgctcccg
    12241 gtggtgatga agctgacccg gccgtcgccg acggtgtagg tcagccgccg gttcacccgg
    12301 taggtgccgc cgtcgacctg cacccacggc aggacacgga gcagccaacg ggaggtgatc
    12361 ccctgcatct gcggcggagt cttggtcgtc gtcgccagat ttcgcgccgc cgcggtaccg
    12421 aggctcagct gctcggattg cggattctcg acgctggatt cggtcatctg tcgcaccacc
    12481 tgacttgtgg tcgtatcgga ggcgcccccg ctggtcgcgg gagcgctggg tcgcgccggc
    12541 gcccggatgc gcggtacgcc cgcggcgggc gcggccgggg ccggcaaggg gctgcggtcg
    12601 ggcgggcgcc cgcggcgtgg agggtccgat gcgcgggcgg ccgcggcgga aggggggagg
    12661 gcccgtgcgg cctgcgtcgg gggcgcgggg gcgccgcacg ggcggtttgg ggccgcggag
    12721 gcggcggatc agccttcgcg gccgatctcg acgttctcca ggattccgag ggcgtcgggg
    12781 accagcacgg cggcggagta gtaggtgctg accaggtagg acatgatcgc cttatcgtcg
    12841 atgcccatga accgcaccga cagccccggc tggtactcgt cgggcaaccc ggtctggtgc
    12901 aggccgacga cgccctgctt ctcctggccg gcgcgcatga ccatgatcgc ggtgctgcgg
    12961 gtggaggtga ccgggatctt gttgcagggg aagatgggca ctccgcgcca ggcgggtacc
    13021 cggtggccct cgacgtcgac gttctgcggg tagacgccgc ggcggctgca ttcgcggccg
    13081 aaggcggcga tcgcgcgcgg gtgggcgatc agaaagctcg ggtccttcca caccgtgccc
    13141 aggagttcgt cgaggtcgtc gggggtgggc gggccggtac gggtggggat gcgctgcttg
    13201 aggtcggcgt tgtgcagcaa cccgaagtcg ctgttgttga ccagctcgtg ctcctggcgc
    13261 tcccgcagcg cctcgaccgt cagccggacc tgctcctcca gctggctcat cggctggttg
    13321 tacagatcgg ccacccgcgt atgcacccgc agcaccgtct gcgccacact cagctcgtac
    13381 tcccgcggtg cggcctcgta gtcgacgaac gtgcccggca ggtccggctc gccggcatgg
    13441 ccggaggcca ccgcgatcgc cgcctcgcca ccggggtcct cctcgcgggc ggggcgcgcg
    13501 tggacctcgg ccacgtgtgc ccgaagcgcg tcggaacggt cggcgacctg ctggaactcc
    13561 gagcgcggca gccagagcac ggtgcagggg gtgaccgcct tggcggtggc gtcccaggag
    13621 ccctcctgct ggaccagggc ggccgagccg aagtggtcgc cgtcgatcat ggtgccgagc
    13681 acggtctcgt ctccgtactc gccggagccc agccggttca ccttcccgtg ggcgatgagg
    13741 tagacgcggt cggcgggggc gccgcgttcg acgatgacgt cgccgggcgc gtactcctcc
    13801 tgggtgaagc gctcggcgag cgcctccagc gcggcctcgt cgccgaagtc gcgcaggagc
    13861 gagagttcgc agagctcccg cgggatcacc cggacgtcgg tgccggcggt gatgaagctg
    13921 acgcggccgt cgccgacggt gtaggtcagc cgccggttca cccggtagga gccgcccgtg
    13981 gcctcgatcc aggggagcag ccgcagcagc caccgtgagg tgatcccctg catctgcggc
    14041 ggagtcttgg tcgtcgtcgc cagatttcgc gcggccgcgg ttcccaggct cagcggttgc
    14101 tgcccgttct ccacaccgga ctcggtcatg gtgcttccac ccgttccttt gctgaccgtt
    14161 gatgctgtgc cgattgttct cgaccggcgt ggcccgcccg cgggaacgat ccccgaatcg
    14221 gccccgcctt gctgcgcgga tgcgtgcaga tgccgcgacc gcgcgttatc cgttggagca
    14281 tgcgaatacg aatccgtttc ctcaggttgc ctgcggaccg ttcatcgtca ccggaccccc
    14341 gaatgcgcgc cgggttcctc cgcctgcctc ccgccttggc ggggccggca ccttcaccgg
    14401 ccgtccatcg cggcgagcca gtctcacgcc tggtcggcac cgcacgtacc cggcgaactc
    14461 ctccgcatgc gacgccatcg gcaactttca tcgcgcatgg gcatcccgca ctcataggcc
    14521 ccgaattcgg cgggtccgga acggccggag cgattatcca gggaatccgc caacctgcat
    14581 aggcgccacc tcagtcggcg ttagggacaa cttgaatctc ctcgccggaa acacaggaaa
    14641 gacgccacca acgtgagcca gtcgcgccat ccggacatcc accaacgggg atatcagcgc
    14701 aactggaatt ccaccccaac gcctttccct tatcataaaa tagccggtta aaccggtcaa
    14761 aaaagaagag cagcccggat gttccgaact gctcagaaga cctcaatttt cgcgtgtggc
    14821 cgcggcggtc cgccgaggcg gccgtccggt cggcgagcgg agaagcctcc cccgccgccc
    14881 ggacggctga gccgctcagg cccccgctgc ggcgggcgtc tcctcctggc gcagaatccc
    14941 gcggacggcc gcctcgatgg cgcccgcgtc gatcccggcc tcgcggcgct gctcatccgg
    15001 cgcggccgaa gccggcatgt gcgaaaccgc cagcttcatc gtccgcggac gggaacgcgt
    15061 gtcggcgaac acgtccagca ccgcgtcgcc gagaccgccc tcgggccagt ggtcctcgac
    15121 cgtgacgatg cgcccggtct cctccgcggc cgcgcgcagc gtcggggcgt ccaccggctt
    15181 gaccgagtag gcgtcgatca cgcgtacggc gaccccctcg ccggccagct tgtcggcggc
    15241 ggccagcgcc tcgtgcaccg tagccccggc tcccacgacc gtcacctcgt cggcgcccga
    15301 ggagcgcagc accttgctac cgccgatctc gaagccctcg tcgggaccgt agagcaccgg
    15361 cgtcttgccg cgcatcgtgc gcaggtagct caccccgtcg tgctcggcca tccccgcggt
    15421 cagccgcgcg gaggagttgg cgtcgcaggg gtgcaggacg acgctgttgt gtaccgcacg
    15481 cagggcggcc atgtcctcca gacccatctg cgagggaccg tcctcgccga tcgacacacc
    15541 cgcgtgggag ccgaccaggt tgatgtcggc ccggctgacg gccgccatgc ggatgaagtc
    15601 gtaggcacgc gtcaggaacg cggcgaacgt ggccgcgtac ggggtccagc cgcggacctg
    15661 cagccccacg gcggcggcga tcatctgctg ctcggcgatg tagaactcga agaaccgctc
    15721 cggatgctcg gcggcgaaga acttcgcccg ggtggagtcg gcgacctcgc cgtccagcac
    15781 gaccacgtcg tcgcgcgcgg tgcccgcggc ggtgaccgcc tggccgaagg cgtcgcgggt
    15841 ggccgcctcc tcgcccacgt cgaaagtggg caggtccacc gccgccccgc cgggccgctg
    15901 acgcaccccg ccgctggtgg gcgcggcgac ctcgatgcgc atgtcgcgcg tgccgcccag
    15961 ctcggagatc gcctcctcgg catcgggcac cggcttgccg tgggcgccct cctggtcggc
    16021 gaccgcgctg accccggcgc ccttgaccgt gcgggcgatg atcgcggtgg ggcggtcggt
    16081 ggtctccgcg gcctcgcggt aggcggcgtc gatctgctcg acgtcgtggc cgtcgatctc
    16141 gaccgtgtgc cagccgaacg cctccacgcg gcgcctgtag gcgtccaggt cccagccgtg
    16201 gcgggtgggt ccgcgctgac ctagccggtt gatgtccagg atcgcggtca ggttggccag
    16261 tcgggcctgt ccggcgtact cgaaggactc ccagaccgag ccttcggcca gctcgctgtc
    16321 gccgcacagc acccagaccc ggtagggcag ccggtccagg ctcgtgcccg ccagggcgac
    16381 gcccgctccg atcggcaggc cctgccccag cgaaccggtg gccacgtcga cccacggcag
    16441 gcggggtgtg gggtggccct ccagcggact gcccagccgc cggtagcgca gcagctcggc
    16501 atcggagatc acgccgcagg ccttgtacag cgagtacagc agcggtgaag cgtggccctt
    16561 ggagaagatc aggtggtcgt tgcccgcgtg ctcgggggcg tcgaagtcgt agcgcaggtg
    16621 cccggacgcg agcaccgcca tcagatccgc cgccgacatc gacgaggtgg ggtgccccga
    16681 tcccgcggcg tcggcagcgc ggaccgcgtc gacgcgcagt tgctgtccca gttccttgag
    16741 ccgttgccgg tcggtcatcg tgtccttcct cctcatgtgg cattgcgccg tcggacggcg
    16801 accgggaccc gctacccgcc gaaggggcgg gcatgcgccg aagcggcgcc tcgcccgggc
    16861 ggtgtgaccg acgcctccag gccgtgtgcg gtggcataag ccagatcgtc gacgacgtcg
    16921 gcggccaggg agcggcggtt gaaggagacg cgctggcgcg cggctccgcc gccgtgggct
    16981 cgcagcgccg tcagcacggc ctgcgcgaag ccgaggtcgc cggagcgctc caggtacggc
    17041 cgcaggtgct ccaccgcccc cgccagcacc ccgtggaccg ggcgcagccg gccgccgttc
    17101 agcggatcgg ggcagctgcc ctccagcccg tcgcgcgcgg cgcgccacag gtcgccgcgc
    17161 agcaccgccg ggtcgcggcg gggtgcgggg cgcccctgcg cggcgtcgtc cagggcggcg
    17221 gcgaccagcg cgcgcacgag caccgcgatc agcgccgact cctcgggcgt ggccggtacg
    17281 tcgcataccc ggatctcgac ggtggggtgg cggtcggaga gcctgatatc ccagtagagc
    17341 atgcgccggt ccagcgcggc gcccgactcc agcagcgcgg cgacgcagtg ctcgtagtgc
    17401 tcggccgact ccatcggcgg cggcgggccc gcggtgggcc agcgcgacca gcggggctgg
    17461 cgccagctgc cgtatccggt gtcggtcccg ccgcagaccg gcgagttggc gctgagcgcc
    17521 agcagcgtcg gcagccaggc gcgcaggcgg ttgccggcct gcaccccgct gtcgcggtcg
    17581 ggcacctcga cgtggacgtg gcagccgcag ttggtgcccg ccgcctcggc cacggcgccg
    17641 aagcgctcgg cgatgcggtg atagcgcgtg ccggggttga gctgctgcgg cccgagctcg
    17701 gccatgacgg gcaccgcacc ggcgatgacg cgcgtgtcca gtcgggcggc ggcctcggcg
    17761 aggcggcggc gcgactcccg cagtcccgcc agcagttcgc cggcgccggc gcagaccggc
    17821 ccggcggcct cgacctggct gcgggtgaac tcgccgagca gctcgccggg accgggaggg
    17881 gccgcgtcga ggacctcgac actgcgaggc gccagtcggc cgtccgcgcc gaccaggaag
    17941 aactcctcct cgacgcccat ggtcggcacg cccgcggcgg gacgcgtgcc tgtctgcgca
    18001 gtgggcatgg atcaccgccg tctccactcg tggtccggct gccggcgggc gcggcggtac
    18061 cgaaagggcc ggcgggtcga cccgcgcccg gtgatccgcc gccgagggct ggtccagatg
    18121 gcggggcggc ggcgcgcgcc gaccggctgg ctggcggacc cggatcgctc gcggtccgga
    18181 cgtatggctg tcgccggacg gctacccccg gcgaccggcg ggtaaccgca tcgccgctgc
    18241 gctcacggcg gttttccggg caggggtgcg ggtagccggt gggaaaagac cggcgaaggt
    18301 gcgaaggagg cgaggacgtg caggtcttcc gcgaccgcga cgacgccgga gagcaactgg
    18361 ccgagcgcgt ccgcgaactc gggctggcgg accccgtcat cctggcgctg ccccgcggag
    18421 gcgtgccggt gggctatgtc gtggccgagc agctgggcgc tccgctggac gtgaccgtcg
    18481 tgcgcaagat cgccaccccc gactttccgg agaccgcggt gggcgccgtg acggccgaag
    18541 gcgcgccgat tctcaacgag ggactgagcc ggatggtccg ggccgacgac gacgagctcg
    18601 cgcgaagcgc cgaagacgaa cgcgccgagg cccggcggcg cgtcaagatc taccgcggcg
    18661 accggcccgc accgcgggtc gccgggcgcg acgtggtggt cgtcgatgac ggtctcgcca
    18721 ccgggatgag cgcccgggcc gcgctgtcgg cgctgggcga ggagggcgcc gcgtcgctga
    18781 cgctggccgt accggtgtgc tcacccgacg ccgcacgcgc gctggaggac gtctgcgacc
    18841 gggtggtatg cgtgcacagt ccgcccgagt tccatgcggt cagcctgtgg tacgagcggt
    18901 ttccccagac ggaggacacc gaggtacagg aactgctgcg ccgggccggc gtctgactgc
    18961 tctccaagaa gcccggggtc ggcccggttc ccggagccgc cgaaggcggc accgatccgg
    19021 ccggctccga gcgcggacgt gcccggtcac ccggatgacg cccgccccgc cgtggcagta
    19081 gggaatctct gcgcggggaa tacgggctac atgggggact tgccgcgccc cttgcgtccg
    19141 gcgcggccgc ttttgcccag gacccgctgg gactgggaga acggcttgga cgcgtagtgg
    19201 ccgatgcggc ccggcaattt gcgcgtgccg atcttcggta tgcccagcag gcgcttgccg
    19261 ccccgctcag gcccgcggga gaggcgtggg agcaggaacg ccagcacgag cagcacggct
    19321 gccgcgacga tgacgacggc gatccacatc gagggcccca tctccggtgc accgaggtgc
    19381 acctggtcga ctgtttgcct cggcttgacc cgctacccgg gatgtccccg acgaacccga
    19441 attcgcgggg cgagcacttc gttgaatcga ttttactcat ccccttcccg cgcttggcga
    19501 ggcgtgttac atttcttctt ccagatccct gggtaagcgc tttcaattac cgacaatctt
    19561 tccgatttcc cagcagagca gggacctccg gggcgtgcgg gcacgcgcgc tcgcactctc
    19621 ggtctcggcg ccgaagaccg cgtccaacgc caacgatcgt tttatcccgt cccccatcca
    19681 tcccccaaac cccgaatacg ggccgcgggc gttgcgtgcc gcggcaccgc ggcgcggcgc
    19741 gggggtgcga ggagcacgaa tgacagacgg catcccccga acaccggcaa ccggcagact
    19801 cgccgcacgc ggcggcgcgg ccgctgcggc gctcgcgctc ggctcggcgg tgctatcagc
    19861 ggccccgccg gcgatcgccg ccaccggctg cgacgtcgac tacaccgtca accagtggaa
    19921 ctccggcttc accgcgaacg tggagatcac caacctcggc gaccccgtcg acggctggac
    19981 gctggagtgg gagttccccg acgaacagcg catcaccggc tcctggaacg gcgagtacag
    20041 ccagtcgggg acgagcgtgc gcgtcgacga cgccggttac aactccgcga tccccgccgg
    20101 cggcaccgtg accttcggct tccaggccac ccataccggc accaacagcg cacccggctc
    20161 cttcacgctc aacggcaccg agtgcgacgg ctccgccgac gatggaaacg acggcgatga
    20221 cggagacgac gggaacggcg acgacggcga cgaccagacc ggcggccgcc aggtcgagga
    20281 cttaaaccgc ggagtggtca gcgtccgctc cggcggcggc aacctggtga gttggcggct
    20341 gctcgcgacc gacccccgcg acgtggcgtt caacctctac cgcggctcga ccaaggtgaa
    20401 ctccgacccc ctcacggacg ccacctccta cctggacgag caggccccgg ccggagccga
    20461 gtactccgtg cgtcccgtcg ccgacggcgg ggagcgcgcg gcgtcgcgca ccgcactgcg
    20521 gttcggcggc ggttacctgg acgtccccct ccaggtgccc tcggggggca gcactcccga
    20581 cggctcctac acctacaccg cgaacgacgc cagtgtgggc gacctggacg gcgacggcgc
    20641 ctacgagatc gtactgaagt ggcagccgag caacgccaag gacaactccc agtccggcta
    20701 taccggcaac accatcgtcg acgcctatga actggacggc acccggctct ggcgcatcga
    20761 cctgggccgc aacatccggg cgggtgccca ctacacgcag ttccaggtct acgacctcga
    20821 cggcgacggc gccgccgagg tcgcgatgaa gaccggcgac ggcaccgtcg acgggcaggg
    20881 cggcgtgatc ggggacgccg gcgccgacca ccgcaactcc agcgggttcg tactacgcgg
    20941 accggagtac ctcaccgtct tcgacggcag caccggggcc gcgctggaga ccgtcgacta
    21001 ccggccgccc cgcggcgatc tcgaagactg gggcgacgac t
//
