LOCUS       NZ_CP036455            21071 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Streptomonospora litoralis strain M2 chromosome, complete genome.
ACCESSION   NZ_CP036455
VERSION     NZ_CP036455.1
KEYWORDS    RefSeq.
SOURCE      Streptomonospora litoralis
  ORGANISM  Streptomonospora litoralis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 5724192)
  AUTHORS   Khodamoradi,S., Hahnke,R.L., Kaempfer,P., Schumann,P., Rohde,M.,
            Steinert,M., Luzhetskyy,A., Wink,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2019) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.3x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004323735.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,076
            CDSs (total)                      :: 5,002
            Genes (coding)                    :: 4,957
            CDSs (with protein)               :: 4,957
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 6 of 46
            Pseudo Genes (incomplete)         :: 39 of 46
            Pseudo Genes (internal stop)      :: 2 of 46
            Pseudo Genes (multiple problems)  :: 2 of 46
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:19:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2283697
            Orig. end                         :: 2304768
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21071
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene-precursor"
                     /region_number="6"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..21071
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21071
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11071](-)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11071)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     misc_feature    complement(70..83)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    1285..1298
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.45"
                     /tool="antismash"
     gene            complement(1620..2360)
                     /locus_tag="EKD16_RS09885"
                     /old_locus_tag="EKD16_10150"
     CDS             complement(1620..2360)
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017573836.1"
                     /locus_tag="EKD16_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10150"
                     /product="thiazole synthase"
                     /protein_id="WP_207391547.1"
                     /transl_table=11
                     /translation="MAGHRFSSRLITGTGGAPSLRILEDALTASGTELTTVALRRVSPD
                     AEGSVWDVLRRNGIRPLPNTSGCFTAGDALRTARLAREALETDWIKLEVIADERTLLPD
                     PVELLDAAERLVDEGFTVLPYTNDDPVLARRLEQVGCAAVMPLGAPIGSGLGIRNPHNI
                     ELIVEQAGVPVVVDAGIGTASEAALAMELGCDAVMLATAITRAEDPVLMAGAMRDAVAA
                     GRGARRAGRIPVRRYAQASSPAVD"
     gene            complement(2468..2668)
                     /gene="thiS"
                     /locus_tag="EKD16_RS09890"
                     /old_locus_tag="EKD16_10155"
     CDS             complement(2468..2668)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565075.1"
                     /locus_tag="EKD16_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10155"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_131098115.1"
                     /transl_table=11
                     /translation="MDVIINGERREVSPRTTVEEVVRSLTQAPGGVAVALNDEVVPKAG
                     WATTRLGDDDRVDVLTAVQGG"
     gene            complement(2659..3882)
                     /gene="thiO"
                     /locus_tag="EKD16_RS09895"
                     /old_locus_tag="EKD16_10160"
     CDS             complement(2659..3882)
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591122.1"
                     /locus_tag="EKD16_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10160"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_131098116.1"
                     /sec_met_domain="DAO (E-value: 2.1e-61, bitscore: 206.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCAATYSSAQRSTDVVVVGAGLIGLVTAWRAARAGLGVTVVAEQL
                     HGSASVVAAGMLTPATEASFGEEALMRFGILSRDRYPGFVAELEEDSGASAGYRAQGTL
                     QVAFDTDDLTRLGHLGDLRARLGLSTERLTGRECRRLEPMLAPSVRGGYFAAEDHSVDP
                     RSLLWALRAAAERRGAVGVRDRVRRVVVDDDGRARGIELDSGGGITAGQVVLAAGVGTP
                     ALEGLPDGVVPPLRPVKGQLLRLRMPPGEGPIVTRTVRGLVKGSPVYLVPRDSGEIVLG
                     ATQEEQGFDTRLTAGGLWEVLRDAHELVPGVSELEIAETCVGLRPGSPDNEPLLGPTAV
                     PGLQLAAGHFRHGVLFTPATGDAMAEALTTGALPDYARRFAATRITGGTPAGADGGPSE
                     GGDQHQWT"
     misc_feature    3873..3889
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.84"
                     /tool="antismash"
     regulatory      complement(3879..3992)
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    3910..3923
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            4146..4505
                     /locus_tag="EKD16_RS09900"
                     /old_locus_tag="EKD16_10165"
     CDS             4146..4505
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591123.1"
                     /locus_tag="EKD16_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10165"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_131098117.1"
                     /transl_table=11
                     /translation="MNENDRDTDTLVGEWMTLKDAAKALNVSPNRIKQFIADHKLLGVR
                     RSGELCIPAAFISGGDVVKGLPGTLTVLSDSGFSTDEALQWMFTPDDTLPGAPIDALVE
                     NRGTEVRRRAQAMAL"
     gene            4722..5372
                     /gene="thiE"
                     /locus_tag="EKD16_RS09905"
                     /old_locus_tag="EKD16_10170"
     CDS             4722..5372
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291493.1"
                     /locus_tag="EKD16_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10170"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_131098118.1"
                     /transl_table=11
                     /translation="MNASLRERLDGARLYLCTDARTERGDLAEFLDSALAGGVDIVQLR
                     DKSLEARRELAVLETVRAACARHGALMSVNDRADIALAAGADVLHLGQGDLPVPHARAV
                     VGDGPLIGRSNSDAEMAAASAEEEAVDYFCVGPTWSTPTKPGRAAAGLELLERTAALKP
                     ARPWFAIGGIDLDNLDRVMAAGAERVVVVRAITEAADPRAAAAEFRRRLAAAD"
     gene            5394..6146
                     /locus_tag="EKD16_RS09910"
                     /old_locus_tag="EKD16_10175"
     CDS             5394..6146
                     /NRPS_PKS="Domain: AMP-binding (1-144). E-value: 5.1e-33.
                     Score: 106.1. Matches aSDomain:
                     nrpspksdomains_EKD16_RS09910_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.5"
                     /locus_tag="EKD16_RS09910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10175"
                     /product="AMP-binding protein"
                     /protein_id="WP_278248942.1"
                     /sec_met_domain="AMP-binding (E-value: 9.2e-44, bitscore:
                     147.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSLHSVVVGGSACPPALMERFEARYGVPVLHAWGMTETSPLGSF
                     ARPPAESAGEERWAYRLSQGRLPATVQGRLIGPDGAPVPCDGTSVGELEVRGPWVTGSY
                     YNDEDPEKFHDGWLRTGDVGTLAPDGFLRLTDRAKDVIKSGGERISSVELENAVMAHPA
                     VAEAAVVAVPDPKWDERPLAAVVLKEGATAGAAELRAFLADRVARWQLPDFWSFVEEVP
                     KTSVGKFDKKSLRGSHASGDLKVVDTRS"
     aSDomain        5397..5825
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKD16_RS09910_AMP-binding.1"
                     /evalue="5.10E-33"
                     /label="EKD16_RS09910_AMP-binding.1"
                     /locus_tag="EKD16_RS09910"
                     /protein_end="144"
                     /protein_start="1"
                     /score="106.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SSLHSVVVGGSACPPALMERFEARYGVPVLHAWGMTETSPLGSFA
                     RPPAESAGEERWAYRLSQGRLPATVQGRLIGPDGAPVPCDGTSVGELEVRGPWVTGSYY
                     NDEDPEKFHDGWLRTGDVGTLAPDGFLRLTDRAKDVIKS"
     gene            complement(6168..7037)
                     /locus_tag="EKD16_RS09915"
                     /old_locus_tag="EKD16_10180"
     CDS             complement(6168..7037)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017581723.1"
                     /locus_tag="EKD16_RS09915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10180"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_131098119.1"
                     /transl_table=11
                     /translation="MGDDRETLHLFGITGATGALGRRIAERLARRGEAQRLIVRDLNRA
                     PELPRAGAAMAAYEDTAAFERAVKGVDTLLLVPAPESDLRVELHLGAIDAALAAGVTRI
                     VYVSFLSAGPAAVYTAARDHFYSEAHIRAAGVAHTVLRPGLYLDLLPSWVDAEGLLRGP
                     AGRGRLAWVSRDDVADAAVAVLTGGDAHEGRTYDLTGPEAVTLGETARRLSALTARRIV
                     YVAETWQESAAWAPSARTGADPAACAAIAAGELDAVSPAVPELTGRPAQSIEGFLRTRP
                     SALHHVRR"
     gene            complement(7129..8448)
                     /locus_tag="EKD16_RS09920"
                     /old_locus_tag="EKD16_10185"
     CDS             complement(7129..8448)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019610777.1"
                     /locus_tag="EKD16_RS09920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10185"
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_242677321.1"
                     /transl_table=11
                     /translation="MDAIRDPARGPVRPDERAPAPDLARGFMLLLIALANTPWYLYAAQ
                     QAGTVAHPADGSAVDRVVQFAMLTAVDGRILPMFALLFGYGLIRLYDRQREAGTRIKAA
                     AAVVQRRNLWLLVLGFAHAALLFTGDILAAYGLTGLVLGWLLLRRSERAMRVTAAVLVG
                     LSLALLLILGLSAAAATLIPAGGGEQAAGSPGFFYDSFSEPGYFASIGPRILGWLFLLP
                     LTVLMPVIPAMIALGMAIGRLRVLERTEHYRGLLAWTAAIGIGGAWLCGLPEALVHVGL
                     VDASETVALSLGGVRQMSGVLGGPGYVALFGLVGDALARRARRGAGVVAVAAVGKRSLS
                     CYLAQSVICAPLLAAWGLGLGAQLGSATMALFAVGVWLVTLVGAYGLERAGRRGPAEAL
                     MRRLVYRSPASTEPAAGVSTAPGADRAGRPSGPGGPPATR"
     misc_feature    8937..8953
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.59"
                     /tool="antismash"
     misc_feature    9393..9406
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.54"
                     /tool="antismash"
     gene            complement(10001..11071)
                     /locus_tag="EKD16_RS09925"
                     /old_locus_tag="EKD16_10195"
     CDS             complement(10001..11071)
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291498.1"
                     /locus_tag="EKD16_RS09925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10195"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_131098121.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1e-43, bitscore:
                     147.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFSASSPVSFVRAAVDGEIARFLDRRRAQLLEVGSELVPVADAL
                     EAMLAGGKRLRPAFCYWGWRGAGGADVAGIHAAAASLEFLQACALIHDDVIDNSDTRRG
                     LPATHKRLESLHAASGWTGSAEAFGRGAAILIGDLCLAWSEDLYQASGLGPEALQTGRV
                     PFDAMRTEVMAGQYLDMLEQVREDGGVEATLRVMHYKAAKYTVQRPLHLGAALAGRYDD
                     LAPVYTDYGLPLGVAFQLRDDILGVFGDPEQTGKPAGDDLREGKRTLIVAETLERTGSA
                     DRAEFLRHLGDPLLSAETVEWMRGAAEDCGALAACERRIDDYVAQATAALETGRIDATA
                     RSALADLVVAATARKH"
     gene            11144..12097
                     /gene="metF"
                     /locus_tag="EKD16_RS09930"
                     /old_locus_tag="EKD16_10200"
     CDS             11144..12097
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591131.1"
                     /locus_tag="EKD16_RS09930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10200"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_131098122.1"
                     /transl_table=11
                     /translation="MPGSPTRNGSAPAAATRPRDIRELLKAGEPTFSFEFFPPKTDEGL
                     RKLWQVIRQIEALAPSFVSVTYGAGGGTRDLTVEITEQLQTDTTLLPVAHFCAVNHSVS
                     ELRHLIGRFASVGVNNILALRGDPPGDPLGEWVKHPEGLEYADELVRLIKELGDFSVGV
                     AAFPYKHPRSPDIESDTKYLVQKCRAGADYAITQMFFDPEDYLRLRDRVAAAGCDTPII
                     PEIMPVVKYSTIGMSEQLSGAPFPRHLAAEFDKVADDPESVRKLGIEQAQRMCERLLDE
                     GAPGIHFITFNQSTATREIYEQVAYDRLPATAGARP"
     gene            complement(12015..12626)
                     /locus_tag="EKD16_RS09935"
                     /old_locus_tag="EKD16_10205"
     CDS             complement(12015..12626)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017591132.1"
                     /locus_tag="EKD16_RS09935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10205"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_131098123.1"
                     /transl_table=11
                     /translation="MRTDIELWELAAPAFLHALPALMEIYAAAMEPPREQLAGRRSIMR
                     EHARNARFRSVIALPRGNADAAGFGYGFHGHPGQWWHDIVSGEVCERDPEAERRWFGDS
                     FEVAELHVLPGHQGRGIGRGLLEALTAARKERTAALSTPAGPTVARSLYLSCGFVDVLP
                     EFHFPGSPHRPFTIMAAPLPLRASGRRRPARRSPAWQWTG"
     misc_feature    12704..12719
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    complement(12705..12718)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            complement(13193..13687)
                     /locus_tag="EKD16_RS09940"
                     /old_locus_tag="EKD16_10210"
     CDS             complement(13193..13687)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017622275.1"
                     /locus_tag="EKD16_RS09940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10210"
                     /product="transcriptional regulator"
                     /protein_id="WP_017591133.1"
                     /transl_table=11
                     /translation="MPSEYAKSLGARLRAIRTQQGLSLHGVEEKSHGRWKAVVVGSYER
                     GDRAVTVQKLAELADFYGVPMSELLPGGAAPTPLGPTPKLVIDLERMQQLPQEKAGPLA
                     RYVATIQSQRGDYNGRVLSIRQEDLRSLAVIYDRSPGDLTEELINWGVLDPEARRAVDA
                     F"
     misc_feature    complement(14049..14065)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.71"
                     /tool="antismash"
     misc_feature    14057..14070
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.17"
                     /tool="antismash"
     misc_feature    14076..14091
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.14"
                     /tool="antismash"
     misc_feature    complement(14078..14091)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.34"
                     /tool="antismash"
     misc_feature    14081..14095
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.83"
                     /tool="antismash"
     gene            14208..14846
                     /gene="pyrR"
                     /locus_tag="EKD16_RS09945"
                     /old_locus_tag="EKD16_10215"
     CDS             14208..14846
                     /EC_number="2.4.2.9"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pyrR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017565064.1"
                     /locus_tag="EKD16_RS09945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10215"
                     /product="bifunctional pyr operon transcriptional
                     regulator/uracil phosphoribosyltransferase PyrR"
                     /protein_id="WP_165498543.1"
                     /transl_table=11
                     /translation="MCAQSRAESDAGASPPDSAESAERVPVPARTVLDGPEIQRALTRI
                     AHEILERTKGGSDITLLGIPSRGVPLARRLAERLERVEGGAVPCGSLDITMYRDDLRLA
                     PARALGRTEIPPEGVDGRLVVLVDDVLFSGRTVRAALDALNDIGRPRAVQLAILVDRGH
                     RELPVRADYVGKNLPTSLRETVTVQLAESDGADAVLLGPAKPRPGEEEG"
     gene            14846..15754
                     /locus_tag="EKD16_RS09950"
                     /old_locus_tag="EKD16_10220"
     CDS             14846..15754
                     /EC_number="2.1.3.2"
                     /GO_function="GO:0004070 - aspartate carbamoyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016597 - amino acid binding [Evidence
                     IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006520 - amino acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1114: ornithine carbamoyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014913461.1"
                     /locus_tag="EKD16_RS09950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10220"
                     /product="aspartate carbamoyltransferase catalytic subunit"
                     /protein_id="WP_131098125.1"
                     /transl_table=11
                     /translation="MRHLLSTGDLSRDEALLVLDTAAELAQVSGRSVKKLPTLRGRTVV
                     NLFYEDSTRTRTSFELAAKRLSADVVNFSAKGSSVSKGESLKDTALTLQAMGADGVVVR
                     HSASGAAHRLAEWVDGAVLNAGDGTHEHPTQALLDVFTMRERLGRLDGLRVAIVGDVLH
                     SRVARSNVLLLHTLGAEVTLVAPPTLVPVSVHTWPCAVSYDLDAVLPKSDVVMLLRVQA
                     ERMHDAFFPTAREYSRRYGLDRERFARMQDDAIVMHPGPMVRGMEISAEVADSARTTVN
                     EQVANGVSVRMAVLYLLLGGS"
     gene            15858..17156
                     /locus_tag="EKD16_RS09955"
                     /old_locus_tag="EKD16_10225"
     CDS             15858..17156
                     /EC_number="3.5.2.3"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011291502.1"
                     /locus_tag="EKD16_RS09955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10225"
                     /product="dihydroorotase"
                     /protein_id="WP_131102305.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.6e-11, bitscore:
                     42.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSSAAYLIRGARIAGGEPADILIRDGAVAEVGPRISAADAAVV
                     DAAGLVALPGLVDLHTHLREPGREDAETVAGGARAAAAGGYTAVHAMANTDPVADTAGV
                     VEQVWRLGRESGHCDVQPVGAVTRGLGGVQLAELGAMADSAAGVRVFSDDGRCVSDALL
                     MRRALEYVKAFDGVVAQHAQEPRLTENAQMNEGVVSDRLGLAGWPAVAEEAVIARDCLL
                     TEHVGSRLHVCHVSTKGSVQILRWAKSRGCDVTAEVTPHHLLLTDDLAESYDPAYKVNP
                     PLRTAEDVHALREGLADGTVDIVATDHAPHPAEAKETEWATAAMGMLGLETALSVVQHT
                     MVDTGLLDWAQLAHRMSALPARIGRLAGHGRPIAPGEPANVTLYDADTASEIDPAALVS
                     KSANTPYRGMRLPGRIQATFLRGIPTVLDGKIK"
     gene            17189..18334
                     /gene="carA"
                     /locus_tag="EKD16_RS09960"
                     /old_locus_tag="EKD16_10230"
     CDS             17189..18334
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="carA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017557794.1"
                     /locus_tag="EKD16_RS09960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_10230"
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="WP_207391548.1"
                     /transl_table=11
                     /translation="MLVLEDGRAFRGRSFGAQGETLGEIVFNTGMTGYQETLTDPSYHR
                     QIVVMTAPHIGNTGVNDDDPESGRIWVSGYVVREPARVASNWRARRTLDEELQRQDVVG
                     IALDGTRALTRHLRDRGAMRAAISTVETDPERLRERVLASPQMAGADLAGEVTTTEPYT
                     VRPPEGVPARFRVAAVDLGIKAMTPQRLAERGCEVTVLPADTTAEAILALEPDGVFFSN
                     GPGDPATAEKPVALMRAVLESRTPLFGICFGNQILGRALDLGTFKLPFGHRGVNQPVQD
                     VHTKRVHITSHNHGFAVDAPADGPFETPYGRAEVSHVDLNDNVVEGLRLLDRPAFSVQY
                     HPEAAAGPHDAAAHFDAFCDLMAASSDPSSSSGRPAEPVQS"
     misc_feature    complement(18693..18706)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     misc_feature    complement(19684..19698)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    complement(20539..20553)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
ORIGIN
        1 gagcccggct cgggatcggt gccgatgacc gtccccgccg gctggtcctc ggagtcggcc
       61 tcctcctcct ggatccgggt gaagccgtcg tcctccagcg ccgcccgggc gtcctgggcg
      121 ttctggccca ccaggtcggg catctcgacc gtctgcggcc ccttggacag gtacaccgtc
      181 accgtgtcct gcgggaggat gcgctcgccc acggcgggct cgacctcggc gatcctgccg
      241 ggatcctcct cggagtagac gcgcttgtcg cccacctcca tgcgcacggg cacgctgccc
      301 agcacggcgg cggcgtcctg ttccggcatg ccgacgatgt cgggtaccgg ctcgtagcgt
      361 ccgaccagga accaccagcc gccggccagc atcaccaccg cgagcacgcc ggcgaccagc
      421 atcatcgggt agctgcggta gtccagggcg agccggcggc gcccgcggcg gccgcgcccg
      481 cccggttcgg ccggagccgc ctcggccaga ccgccggtct cgaccacgag ggtgtcgttg
      541 ccgccggagc cgggagggga cgcgtcggcg ctgtactccc cgctcgcgtc cgacttggtg
      601 ttcagcacca gcgcgaggta ctgcccggcg tcgccgggcc ggtagcgggg gtcgcgctcg
      661 gtggcgcggg tgaccagcgt gtcgatctgc ggaggcaggc ccgcgaccac ccgggagggc
      721 cgcgggacgt cctcgttgac gtgctggtag gcgatggaga tgggggtgtc gccggtgtgc
      781 ggctgcgtcc cggtcagcag ctcgtagagc atgatcccgg ccgcgtagac gtcggtgcgc
      841 gcatcggcgg cgccgcgctc gatctgctct ggtgccagat aggcggcggt acccatgacc
      901 gcgccggtct tggtggtgcc ctgctgggcg gactccaccg cccgggccag accgaagtcg
      961 gcgaccttga cgcggccgtc ctcggtgagc agcacgttct ccggcttgac atcgcgatgg
     1021 accagcccgg cctggtgcgc ggcgcccagc gccgcaagca ccggggagat gatgtcgagc
     1081 gcgtcggcgg gtgccaggcg cccccgctcg ttcagcatct cgcgcagtgt ctgcccgggc
     1141 acgtactcca tggccaggta cacgtgcccc tggtcggtgc cctggtcgta gacctgcacc
     1201 acgttggggt gggagagctt ggcgaccgag tgcgcctcgt tgatgaagcg gcgcacgaaa
     1261 gcggggtcct gggccagcga ggcgtgcatc accttgcagg ccaggcggcg gtccagccgc
     1321 aggtcgcggg cgacgtagac cgtggccata ccgccgctgg ccacccgcgc ctcgacgtgg
     1381 tagcggtgat cgagtgtcgt gcccaccaga gggtcggcag tcgtcatgtc cacacagggg
     1441 agtgtaaggc gtccgcgaag ggaggtcgtc gcgaaccgtg ccacgaggcc ggtaccgcgc
     1501 gcttcggatt ccccgggtcg cggtgccgcg gggttcgtgg tgacgtttcc tgcgccgcgc
     1561 ccggtcccgc gtgtgtcggc gggcgcggcg gcgcggtgcg ccgggcgcac cggcggcggt
     1621 cagtccaccg cgggggagga cgcctgcgcg tagcgccgca ccgggatgcg tccggcgcgg
     1681 cgggcgccgc gaccggcggc caccgcgtcg cgcatggcgc ccgccatcag aacggggtcc
     1741 tcggcccggg tgatggcggt cgccagcatg accgcgtcgc agcccagctc catggccagc
     1801 gccgcctcgc tggcggtgcc gatcccggcg tcgacgacca cggggacgcc cgcctgctcc
     1861 acgatcagct cgatgttgtg cgggttgcgg atgcccagac ccgagccgat gggggcgccc
     1921 agcggcatca cggcggcgca gcccacctgc tccaggcgcc gcgccagtac ggggtcgtcg
     1981 ttggtgtagg gcagcacggt gaacccctcg tcgaccagcc gctcggcggc gtcgagcagt
     2041 tcgaccgggt cgggcagcag agtgcgctcg tcggcgatga cctccagctt gatccagtcg
     2101 gtctccagcg cctcgcgggc caggcgcgcg gtgcgcagcg cgtcgccggc ggtgaagcag
     2161 cccgaggtgt tgggcagcgg ccggattccg ttgcggcgca gcacgtccca caccgagccc
     2221 tcggcgtcgg gggagacgcg gcgcagggcc acggtggtca gttcggtgcc cgaggcggtc
     2281 agcgcgtcct ccaggatgcg cagcgacggc gcgcccccgg tgccggtgat cagccgggag
     2341 gagaaccggt ggccggcgat gacgaggggg tcggcgccga cttcggcgcc gggtccgccg
     2401 gtcgggtcgg tgaagggcgt gtcggcggtc gcccgcgggg ccgccggggt gtgcgtgtcg
     2461 gtcaacttca gcctccttgg accgcggtga gcacgtcgac gcggtcgtcg tcgccgaggc
     2521 gggtggtggc ccatccggcc ttgggcacga cctcgtcgtt gagcgcgacg gccacgccgc
     2581 cgggcgcctg cgtgagcgag cgcaccacct cctccaccgt cgtcctggga gagacctcgc
     2641 ggcgctcgcc gttgatgatc acgtccactg gtgctgatcg cctccctcgc tggggccgcc
     2701 gtccgcaccg gcgggggttc cgccggtgat gcgggtggcg gcgaaccggc gcgcgtagtc
     2761 ggggagcgcg ccggtggtca gtgcctcggc catggcgtcg ccggtggccg gtgtgaacag
     2821 cacgccgtgc cggaagtggc cggcggccag ttgcaggccg gggaccgcgg tcggtcccag
     2881 cagcggctcg ttgtcggggg atccggggcg caggccgacg caggtctccg cgatctccag
     2941 ttcgctcact ccgggtacca gttcgtgggc gtcgcgcagc acctcccaga gtcctccggc
     3001 ggtcagccga gtgtcgaagc cctgctcctc ctgggtggcg ccgagcacga tctcgccgga
     3061 gtcgcgcggc accaggtaga ccggcgagcc tttgaccagc ccgcgcacgg tgcgggtgac
     3121 gatgggccct tcgccggggg gcatgcgcag gcgcagcagt tggcctttga cgggccgcag
     3181 cggcggcacc acgccgtcgg ggaggccttc gagggccggg gtgccgaccc ccgcggccag
     3241 caccacctgg ccggcggtga tcccgccgcc ggagtcgagt tcgatacccc gggcgcggcc
     3301 gtcgtcgtcg acgacgaccc ggcggacgcg gtcgcgcacg ccgacggcgc cgcggcgctc
     3361 ggccgcggcg cgcagtgccc acagcaggga gcgcgggtcg acggagtggt cctccgcggc
     3421 gaagtagccg ccgcgcaccg agggcgccag catcggctcc agcctgcggc actcgcggcc
     3481 ggtgagccgc tcggtggaca gcccgagccg ggcgcgcagg tcgccgaggt ggccgagccg
     3541 ggtgaggtcg tcggtgtcga aggcgacctg cagggtgcct tgggcgcgat agccggccga
     3601 ggcgccgctg tcctcctcca gttcggcgac gaacccggga tagcggtcgc gggagaggat
     3661 gccgaaccgc atcagcgcct cctcgccgaa ggaggcctcg gtggcggggg tcagcatgcc
     3721 ggcggcgacc acggaggccg agccgtggag ctgttcggcg accacggtga cgcccagccc
     3781 ggcgcgggcg gcgcgccacg ccgtgacgag gccgatgagc ccggcgccga cgacgaccac
     3841 gtcggtgctc cgctgagcgg aggagtaagt cgctgcgcac acgttgctac tgccacttcc
     3901 ttcgccggta tgacccggat caggttcatg cggtcggagg ctgacagcct ccctctcagc
     3961 cgggtcccga cccggctccc gcgggtgtat ctcgtccggc gcccattcta tgacctcgcc
     4021 cgccggagtg cccgggccgg gcggcgggga tttcgggcgg gcgggcccga ccgcgtcgct
     4081 tcgcctacag cgatacgcgt gcgcgggggc gtttgacgcg gggtcggctg tggcacattg
     4141 gacccgtgaa cgagaacgac cgcgacaccg acacccttgt cggtgaatgg atgacgctga
     4201 aggacgccgc caaggcgctg aacgtcagcc cgaaccggat caagcagttc atcgccgacc
     4261 acaagctgct cggggtgcgg cgcagcggcg agctgtgcat cccggccgct ttcatctccg
     4321 gcggcgacgt cgtcaagggc ctgcccggca ccctcaccgt gctgtccgat tccgggttca
     4381 gcaccgatga ggccctgcag tggatgttca ccccagacga cacgctgccg ggggcgccca
     4441 tcgacgcgct ggtggagaac cgcggcaccg aggtccgccg ccgcgctcag gcgatggcgt
     4501 tgtagagcgg gcgcggcgcc tgtgtcgggg caccgggcgc ccgcgtgtcc gctatgccgg
     4561 gtgtcgcggg cgccttcgtg cgcgcatcgc gaaagaacgg cctcggattc gggaatccgc
     4621 gcacggcggc tgaggagccg aggcgccgcc gggctgcacc gagccgaccg gcgggccgac
     4681 cgacccgatc agacacctgc cccgtcgtct aggctggccg cgtgaacgcg agtctgcgag
     4741 agcgcctgga cggggcgcgc ctgtacctgt gcaccgacgc ccgcaccgaa cggggcgatc
     4801 tggccgagtt cctcgactcc gcgctggcgg gcggcgtcga catcgtccag ttgcgcgaca
     4861 agtccctgga ggcccgccgg gagctcgcgg tcctggagac cgtgcgggcc gcgtgcgcgc
     4921 gccacggcgc gctgatgtcg gtcaacgacc gcgccgacat cgcgctggcc gcgggcgcgg
     4981 acgtgctgca cctggggcag ggggatctgc cggtgcccca cgcgcgcgcc gtcgtcggcg
     5041 acggcccgct gatcggccgg tcgaacagcg acgcggagat ggcggcggcc tccgccgagg
     5101 aggaggccgt ggactacttc tgcgtcgggc cgacgtggag cacgcccacc aagccgggcc
     5161 gtgcggcggc cgggctggag ctgctggagc gcaccgccgc cctgaagccg gcgcgcccct
     5221 ggttcgcgat cggcggcatc gacctggaca acctcgaccg ggtgatggcg gccggcgccg
     5281 agcgcgtggt ggtcgtgcgc gccatcaccg aggccgcgga cccgcgcgcc gccgcggcgg
     5341 agttccgccg caggctcgcc gccgccgact gagcccgcgc cgcgccgcgc gacatctcct
     5401 cgctgcacag cgtcgtggtc ggcggatcgg cctgcccgcc cgcgctgatg gagcgcttcg
     5461 aggcgcgcta cggggtgccg gtgctgcacg cctggggcat gaccgagacg tcgccgctgg
     5521 gcagcttcgc gcgcccgccc gccgaatccg ccggggagga gcgctgggcc taccggctca
     5581 gccagggccg cctgcctgcc acggtgcagg gcaggctcat cggccccgac ggcgcgccgg
     5641 tgccctgcga cggcacctcc gtcggcgagc tggaggtgcg cggcccctgg gtcaccggct
     5701 cctactacaa cgacgaggac ccggagaagt tccacgacgg ctggctgcgc accggcgacg
     5761 tgggcacgct cgcccccgac ggcttcctgc ggctcaccga ccgcgccaaa gacgtgatca
     5821 agtccggcgg cgagcggatc tcctcggtcg agctggagaa cgccgtcatg gcccacccgg
     5881 cggtcgccga ggccgccgtc gtggcggtac ccgacccgaa gtgggacgag cgccccctgg
     5941 ccgcggtcgt tttgaaggag ggcgcgaccg ccggcgccgc ggagctgcgg gccttcctcg
     6001 ccgaccgcgt cgcgcgctgg cagctgcccg acttctggag cttcgtcgag gaggtcccca
     6061 agaccagcgt cggcaagttc gacaagaagt cgctgcgcgg cagccacgcc tcgggcgatc
     6121 tcaaggtcgt cgacacccgt tcctgagcgt cacgggccgc gcccggctca ccggcgcaca
     6181 tggtgcagcg cgctgggccg ggtgcgcagg aaaccctcga tggactgggc cgggcgcccg
     6241 gtcagctccg gcacggcagg cgagaccgcg tccagctcgc cggcggcgat ggcggcgcag
     6301 gccgcggggt cggcccccgt ccgcgcgctc ggcgcccagg cggccgactc ctgccaggtc
     6361 tcggcgacgt agacgatcct gcgcgcggtc agcgccgaga ggcggcgcgc ggtctcgccc
     6421 agggtgaccg cctcggggcc ggtcaggtcg taggtgcggc cttcgtgcgc atcgccgccg
     6481 gtgagcacgg ccaccgccgc gtcggccacg tcgtcgcgcg agacccacgc cagccgcccc
     6541 cgcccggccg ggccgcggag gagcccttcg gcgtcgaccc acgaaggcag cagatccagg
     6601 tacaggccgg gccgcaggac ggtgtgggcc actcccgcgg cgcggatgtg cgcctcgctg
     6661 tagaagtggt cgcgcgcggc ggtgtagacc gccgccggcc cggccgagag gaacgacacg
     6721 tagacgatgc gggtcacacc cgccgccagg gccgcgtcga tggcgccgag gtgcagttcg
     6781 acacgcagat cggactccgg cgccggtacc agcagcaggg tgtcgacgcc cttgaccgcg
     6841 cgctcgaagg cggcggtgtc ctcgtaggcg gccatcgcgg cgccggcgcg gggcagttcg
     6901 ggggcgcggt tgaggtcgcg gacgatgagc cgctgggcct ccccgcgccg cgccagccgc
     6961 tcggcgatcc gccgcccgag ggcccccgtg gcgcccgtga tgccgaagag gtgcagtgtc
     7021 tcccgatcgt cgcccatggt ccgcattgtc cggcaacatc ccggccgcgt catcgaccgc
     7081 gggacaacac ccccggcaac cgccgtcccg cggcggtttc cgcggtcctc agcgcgtcgc
     7141 gggcggtccg cccgggccgg agggtcttcc cgccctgtct gcgccgggcg cggtcgacac
     7201 cccggccgcc ggctccgtgc tcgccgggga gcggtagacc agccgccgca tcagcgcctc
     7261 ggccggcccg cggcggccgg cgcgctccag gccgtaggct ccgaccagcg tgaccagcca
     7321 cacgcccacg gcgaacagtg ccatcgtcgc gctgcccagt tgcgcgccca gccccagccc
     7381 ccaggcggcc agcagcggag cgcagatcac cgactgggcc aggtagcacg acagcgagcg
     7441 cttgccgacg gcggcgacgg cgaccacgcc cgcaccgcgc cgcgcccggc gggccagcgc
     7501 atcgccgacc aggccgaaca gggcgacgta gccgggcccg ccgaggacgc cgctcatctg
     7561 ccgcaccccg cccagcgaga gtgcgacggt ttcggatgcg tcgacgagcc cgacgtggac
     7621 cagcgcttcg ggcagcccgc atagccacgc gccgccgatc ccgatcgcgg ccgtccaggc
     7681 cagtaggccg cggtagtgct cggtccgctc caatacgcgg agtcggccga tcgccatgcc
     7741 cagcgcgatc atggccggta tgaccggcat gagtaccgtc agtggcagca agaagagcca
     7801 gccgaggatt cgggggccga tggaggcgaa gtagccgggt tcgctgaagc tgtcgtagaa
     7861 gaagccgggc gatcccgcgg cctgttcccc gccccctgcc gggatcagcg tggccgcggc
     7921 cgccgacagg ccgaggatca gcagcagcgc cagtgagagt ccgaccagca cggcggcggt
     7981 gacgcgcatc gcccgctcgc tgcggcgcag tagtagccag cccaggacca ggccggtcag
     8041 gccgtaggcg gccaggatgt ccccggtgaa cagcagggcc gcgtgcgcga aaccgagcac
     8101 cagaagccac aggttgcggc gttgcacgac cgcggcggcc gccttgatcc gggtgccggc
     8161 ctcgcgctgg cggtcgtaga ggcggatcag cccgtagccg aacagaaggg cgaacatcgg
     8221 caggatgcgc ccgtccaccg ccgtgagcat ggcgaactgc acgacgcggt cgaccgccga
     8281 tccgtcggcg ggatgggcga ccgtgcccgc ctgctgggcg gcgtacagat accagggtgt
     8341 gttggccagc gcgatgagca gcagcatgaa cccgcgcgcg aggtcgggcg ccggcgcccg
     8401 ctcgtcgggg cgcacgggac cgcgggcggg gtctcggatg gcgtccacgg cagtgcctcc
     8461 agcaggggat gaaggtcccc cgaagggggc ttttccctca gaatgcacca atcgccgttg
     8521 cgacggcatc ctccgcaagt cggtaggccc cccgacttcc ggctcgggcc ggtccctgag
     8581 aggcggtagg ggtaggcgtc cgggcctgtg gtggtcgggt tgggtgttcg ccggtggcgc
     8641 gcccggcggg ggcggctcag gcccgctgag cggccttgcc gacctgccgg gaaacgggcg
     8701 gacttaacgg aaaagcggcg gcgacgacgg cggggccggg cctgcgtggt cggggcggcg
     8761 gtcaccggcc ccggccgcgg tggtcgagcc ccggggggcc gccgcccggt tgtcggcgcg
     8821 ggcctgcggg gcggtgggcg gcggccatac agccggatcg ggccacgaga tgcacctacg
     8881 tgcggcggca tcggcctcgg cgtcgccccg acgtgccgtc ctggcgctgc cattccgcga
     8941 tacgaaacaa cacggggtgc tttgtccgcc aatgcccgat tcctcggtgg gtccgcggcc
     9001 gcgctgcggc ggcggtggcc cacgaagcgc gccgaatggc gcgaaaacag tcccggagtc
     9061 aacttttcgt gcgcctcgtg gccgcggcgc ccgccgagac cgcccgcaaa acggacatag
     9121 acccccaaaa gcccacccca tcagaggggt ggagcccccg ggggccgcgc ccgggcgcca
     9181 cgagcgacgt gtcgtcgccc cccggccccc gatccggcgc actcccgggg cgtgcgagca
     9241 cccgcgaccg cgccccgcag cgcggccacc cccacgcgcg ggcccggccc caacgcggcg
     9301 gcacccagcc ggccaaccgg cgccggtatg tccggtatgc cggttcatcc ggcgatgatc
     9361 gcgaacttat ggccgcggaa tacgccttcc tgcgaccata agttcgcgat agacgggaga
     9421 agccgggacc ggtgccgccc aacgcagggt tttaaccaga cagcggccgc gggttcaggg
     9481 ggtgagtgca acaccggctc cgcacggagg tgttgtgatg aatacccacc cccggggggc
     9541 ggcccccgct gcccgccgaa cacgagcacc gggtgcgtcg gccgccggcc ggacccggcg
     9601 ccgtcctcgg cgccgctttt ccgtgaggcc acccgtttcc cggcagacca acaaggccgc
     9661 acagccaacc gctgccgccc cgccgcaacc gccaccggcg gcacccgacc cggtgaccgc
     9721 gggcccggcc atccggcgcc ctcgccgccc ctcgccggcc gccgccaccg gcggcacccg
     9781 acccggtgac cgcggagccc ggccccgctg ccaccgttgc cgccgcctcc ccgaagacac
     9841 ccgcacgccg gcagaccaac aagaccgcac agcagacccg acccgcccta cgtcggtcgc
     9901 cctgcccgcc ttagcggtca gcgaccgcct tccggcccac cgccttccgg cccaccgcct
     9961 tccggccgac cgccccgtcc gccggagtcc gcgatccccc tcagtgcttg cgggcggtgg
    10021 cggcgacgac gaggtcggcg agggccgagc gggcggtggc gtcgatccgc ccggtctcca
    10081 acgccgcggt ggcctgggcg acgtagtcgt cgatgcggcg ctcgcaggcc gcgagggcgc
    10141 cgcagtcctc ggccgcaccg cgcatccact cgaccgtctc ggcgctcagc aaggggtcgc
    10201 ccagatggcg caggaactcc gcgcggtcgg cggatccggt ccgctccagc gtctcggcga
    10261 cgatgagggt gcgcttgccc tcccgcaggt cgtcccccgc tggcttgccg gtctgctcgg
    10321 ggtcgccgaa gacgccgagg atgtcgtcgc gcagttggaa ggccaccccc agcggcagcc
    10381 cgtagtcggt gtagacgggc gcgaggtcgt cgtagcgccc ggccagcgcg gcgcccaggt
    10441 gcagcggccg ctgcacggtg tacttggccg ccttgtagtg catgacccgc agcgtcgcct
    10501 cgacgccgcc gtcctcgcgc acctgttcca gcatgtccag gtactgcccg gccatcacct
    10561 cggtgcgcat cgcgtcgaag gggacgcgcc cggtttgcag cgcctccggg cccagcccgc
    10621 tggcctggta gaggtcctcg ctccaggcca ggcacagatc gccgatcagg atcgcggcgc
    10681 cgcggccgaa cgcttcggcc gagcccgtcc agcccgaggc cgcgtggagg ctctccaggc
    10741 gcttgtgggt ggcgggcagg ccgcggcggg tgtcgctgtt gtcgatcacg tcgtcgtgga
    10801 tcagcgcgca ggcctgcagg aattccagcg aggccgcggc ggcgtggatc ccggcgacgt
    10861 cggcgccgcc ggctccgcgc cacccccagt agcagaacgc cgggcgcagc cgcttgcccc
    10921 ccgcgagcat ggcctccaac gcgtcggcga ccggcaccag ctcggagccg acctccagca
    10981 gctgggcgcg ccgccggtcg aggaagcggg cgatctcccc gtcgacggcg gcgcggacga
    11041 aggagaccgg ggaggaggcg gagaaggaca tagcctgcag gttatcgggt agccggtacc
    11101 cacctgctcc ccctcccgaa gggcttcgcc taaggtagag gacatgcctg ggtcaccgac
    11161 acgcaacggg agcgcgcccg ccgcagcgac gcggccgcgc gacatccgcg aactgctcaa
    11221 agccggcgaa ccgacattct ctttcgagtt cttcccaccg aagaccgacg aggggctgcg
    11281 caaactctgg caggtcatcc gccagatcga ggcgctggcg ccctcattcg tctcggtcac
    11341 ttacggagcc gggggcggga cgcgcgatct caccgtggag atcaccgagc agctgcaaac
    11401 cgacacgacg ctgctccccg tcgcccactt ctgcgccgtc aaccactccg tgagcgagct
    11461 gcgccacctc atcgggcgct tcgccagcgt gggtgtgaac aacatcctcg ctctgcgcgg
    11521 cgacccgccc ggcgacccgc tgggcgaatg ggtcaagcac cccgagggcc tggagtacgc
    11581 cgacgagctg gtgcggctca tcaaggagct cggcgacttc agcgtcggcg tcgcggcctt
    11641 cccctacaag cacccgcgct cgcccgacat cgagtccgac acgaagtacc tcgtgcagaa
    11701 gtgccgtgcg ggggccgact acgccatcac ccagatgttc ttcgacccgg aggactacct
    11761 gcggctgcgc gaccgcgtgg cggcagcggg ctgcgacacc cccatcatcc cggagatcat
    11821 gccggtggtg aagtactcca cgatcgggat gtccgagcag ctctccggcg cgcccttccc
    11881 gcgccacctg gccgcggagt tcgacaaggt cgccgacgat ccggagtcgg tgcgcaagct
    11941 cggcatcgag caggcgcagc ggatgtgcga gcggctgctg gacgagggcg ctcccggcat
    12001 ccacttcatc acgttcaacc agtccactgc cacgcgggag atctacgagc aggtcgccta
    12061 cgaccgcttg cccgcaacgg caggggcgcg gccatgatcg tgaagggccg gtgaggactg
    12121 ccggggaagt ggaactccgg tagcacgtcg acgaaaccac acgagaggta caggctccgg
    12181 gcgaccgtgg gtccggccgg ggtcgacagg gcggcggtgc gctccttgcg cgccgccgtc
    12241 agtgcttcca gcaggccgcg cccgatgccg cggccctggt ggccgggcag cacgtgcagt
    12301 tcggccacct cgaaggagtc gccgaaccag cgccgctcgg cctcgggatc gcgctcgcac
    12361 acctcgcccg agacgatgtc gtgccaccac tgccccgggt ggccgtggaa gccgtagccg
    12421 aacccggcgg cgtccgcatt gccccgggga agcgcgatca ccgagcggaa ccgcgcgttg
    12481 cgggcgtgct cgcgcatgat ggagcgccgc ccggccagct gctcgcgcgg gggctccatc
    12541 gcggcggcgt agatctccat cagggcggga agggcgtgca ggaacgccgg ggcggccagc
    12601 tcccacagct cgatgtcggt gcgcacaccg ccacggtaga cgaagcgggc ccgccggggg
    12661 cgttgttgac gccggcgacg ggggtgcgct taactgtcct tgttcgtact tctgttcgaa
    12721 gtagcgggag tgcggacggt ccgtgttcgc cgccgcgtag gcgacgcgcg aacgcgggaa
    12781 gcggccgggc ggggggaggg gaagcctctt gcccggccgc ggccatcccc gggcggaaag
    12841 ggcgcgcccg tccggggggc gggtgccgcc cctccttgcg gccccgcaga cgacgagcgg
    12901 ccgtgtcccc gtgggaaacc gtgcggggac acggccgctc gtcgtctgcc gccgcgtcgt
    12961 gcgcggcgcg tgcctgtgcg cgcggtcgca ccgcgccgcg gggagagggg acggaccgtc
    13021 cgggtcggcc cgggtgctgc ggccgcctcc ttgcgcggcc gcaggcggtg aggggcgctc
    13081 cccggcccgg gtcagggggc gccggcgcag ggcgccggga ggacgcgcgc ggctgcgagg
    13141 ggcgcgcgtc tccggggccg ctggagctcg gctggaaggc gttccggctc gactagaacg
    13201 cgtcgacggc gcggcgcgct tcggggtcga ggacgcccca gttgatcagc tcctcggtca
    13261 ggtcgccggg cgagcggtcg tagatgaccg ccagcgagcg caggtcctcc tggcgaatgg
    13321 acagcacccg gccgttgtag tcgccgcgct ggctctggat ggtggccacg tagcgggcga
    13381 gcgggccggc cttctcctgc ggcagctgct gcatccgctc caggtcgatc accagcttgg
    13441 gcgtgggccc cagcggggtc ggtgcggcgc cgccgggcag cagctccgac atgggcacgc
    13501 cgtagaagtc ggcgagctcg gcgagcttct gcacggtcac ggcgcggtcg ccgcgctcgt
    13561 aggatcccac cacgacggcc ttccagcggc cgtgggactt ctcctccact ccgtgcaggg
    13621 agagcccctg ctgggtgcgg atggcgcgca gccgcgcacc gagggacttg gcgtattccg
    13681 atggcatctt cttcgtcgct ccccggccgt gaaggtggct ggtgcgggcg gtgggccccg
    13741 agtgcgcccg tggtgaccgc gcccggccga gggcgcccgg tgggtgccat ccgcagggcc
    13801 cggacgaaag cggtcccgcc cgagattggt tacggacagt gacggtaagg ctgttcggtt
    13861 gccaggtcaa gccgttgggt ggaaacgcga cgattcagtg gccaaaccgt gtgtaagtga
    13921 ggggactctc atttcgggac cgatgcggac atcccgtgca gcttcggtgt acggaaaggc
    13981 cgctgacacg gggattccga ctgatcgccc gacatgcgca ccgcccgtgg cgtccgtttc
    14041 accgaacgat gggatgatat gtcaagaata ccgcatgtga tgagagtcat attttctacc
    14101 ggtttcgggg ggctgtcgat cagcgccgcg gcgccgcgct gataacgtga agtcgttcga
    14161 catcctttaa ccgcctgtcc agtgaggcag ggaagggggt cactactgtg tgtgcgcaat
    14221 ctcgcgctga gagtgatgcg ggcgcatcgc cgcccgattc cgccgaatcc gcggaacgcg
    14281 tccccgtgcc ggcgcggacc gtcctggacg gtcccgagat ccagcgggcg ctgacccgca
    14341 tcgcccacga gatcctggaa cgcaccaagg gcggaagcga catcaccctg ctgggcatcc
    14401 cctcgcgggg cgtcccgctg gcccgccgcc tggccgagcg cctggagcgc gtcgagggtg
    14461 gggccgtccc ctgcggctcg ctcgacatca cgatgtaccg cgacgatctg cggctggcgc
    14521 ccgcccgcgc gctcgggcgt accgagatcc cgcccgaagg ggtcgacggg cgcctcgtcg
    14581 tcctcgtcga cgacgtgctg ttctccggcc gcacggtgcg cgccgcgctc gacgccctca
    14641 acgacatcgg ccgcccccgc gcggtgcagc tcgccatcct cgtcgaccgc ggccaccgcg
    14701 agctgcccgt ccgggcggac tacgtgggca agaacctgcc cacctcgctg cgcgagaccg
    14761 tgaccgtgca gctggccgag tccgacggcg ccgacgccgt cctgctgggc ccggccaaac
    14821 cgcgccccgg cgaagaggag ggctgatgcg ccacctgctg tccaccggcg acctctcccg
    14881 cgacgaggcg ctgctggtgc tcgacaccgc cgccgagctt gcccaggtca gcggccgctc
    14941 ggtgaagaag ctgcccacgc tgcgcggccg caccgtggtc aacctcttct acgaggactc
    15001 cacccgcacc cgcacctcct tcgagctcgc cgccaagcgg ctctcggccg acgtggtcaa
    15061 cttctccgcc aagggctcca gcgtctccaa aggcgagagc ctcaaggaca ccgcgctgac
    15121 actgcaggcc atgggcgccg acggcgtggt cgtgcggcac agcgcctccg gcgcggccca
    15181 ccgcctcgcc gagtgggtcg acggcgccgt gctcaacgcg ggcgacggca cccacgagca
    15241 ccccacccag gcgctgctgg acgtcttcac catgcgcgag cgcctgggac ggctcgacgg
    15301 actgcgcgtg gccatcgtcg gcgacgtcct gcacagccgc gtggccagat ccaacgtgct
    15361 gctgctgcac accctgggcg ccgaggtcac cctggtcgcc ccgcccaccc tggtcccggt
    15421 gtcggtgcac acctggccct gcgcggtctc ctacgacctc gacgccgtgc tgcccaagag
    15481 cgacgtggtc atgctgctgc gggtgcaggc cgagcgcatg cacgacgcgt tcttccccac
    15541 cgcgcgcgag tacagccgcc gctacgggct cgaccgcgag cgcttcgccc gcatgcagga
    15601 cgacgccatc gtcatgcacc cgggccccat ggtccgcggg atggagatct ccgccgaggt
    15661 cgccgactcc gcgcgcacca ccgtcaacga gcaggtcgcc aacggcgtca gcgtccgcat
    15721 ggccgtgctc tacctgctcc tgggcgggtc ctaagccctg ccgccgccgc gcgccccgtg
    15781 ccccgcgtcc cacgccgcgg gggccgcggc ccgcgcccgc ccgcaccgca accactgaca
    15841 aagaagcgat ggaagagatg acccagagca gcgccgccta cctgatccgc ggcgcccgca
    15901 tcgccggggg cgagccggcc gacatcctga tccgcgacgg cgccgtggcc gaggtcggcc
    15961 cccgaatcag cgcggccgat gccgccgtcg tcgacgccgc cgggctcgtc gccctgcccg
    16021 gactggtcga cctgcacacc cacctgcgcg agcccggccg cgaggacgcc gagaccgtgg
    16081 ccggcggcgc ccgcgccgcc gccgcgggcg gctacaccgc cgtgcacgcc atggccaaca
    16141 ccgaccccgt cgccgacacc gccggcgtgg tcgagcaggt ctggcgcctg ggccgcgaat
    16201 ccggccactg cgacgtgcag cccgtgggcg cggtcacccg cgggctcggc ggcgtccagc
    16261 tggccgaact gggcgccatg gccgactccg cggccggggt gcgcgtcttc tccgacgacg
    16321 gcaggtgcgt ctccgacgcg ctgctgatgc gccgcgccct ggagtacgtc aaggcgttcg
    16381 acggagtggt cgcccagcac gcccaggagc cccggctcac cgagaacgcc cagatgaacg
    16441 agggcgtggt ctccgaccgg ctgggccttg cgggctggcc ggccgtggcc gaggaggccg
    16501 tcatcgcccg cgactgcctg ctcaccgagc acgtcggctc gcggctgcac gtctgccacg
    16561 tctccaccaa gggctcggtg cagatcctgc gctgggccaa gagccgcggc tgcgacgtca
    16621 ccgccgaggt cactccgcac cacctgctgc tgaccgacga cctcgccgag agctacgacc
    16681 ccgcctacaa ggtcaacccg ccgctgcgca ccgccgagga cgtgcacgcg ctgcgcgagg
    16741 gcctggccga cggcaccgtc gacatcgtcg ccaccgacca cgcgccgcac ccggccgagg
    16801 ccaaggagac cgagtgggcc accgcggcga tgggcatgct cgggctggag accgcgctct
    16861 cggtcgtcca gcacaccatg gtcgacaccg gcctgctcga ctgggcccag ctggcccacc
    16921 ggatgtcggc ccttccggct cgcatcggac gtctcgcagg tcacgggcgt cccatcgccc
    16981 ccggcgagcc cgccaacgtt acgctgtatg acgcggacac cgcttcggaa atcgacccgg
    17041 cggccctggt ctccaagagc gcgaacaccc cctaccgggg catgcgcctg cccggccgca
    17101 tccaggcgac gttcctgcgc ggcatcccca cggttctcga tgggaagatc aagtgactcc
    17161 accagcagcc tccggccacg ccgacgccat cctggttctg gaggacgggc gcgccttccg
    17221 cggccggtcc ttcggcgcgc agggggagac cctcggcgag atcgtcttca acaccggcat
    17281 gacgggctac caggagacgc tcaccgaccc gtcctaccac cggcagatcg tcgtcatgac
    17341 ggccccgcac atcggcaaca ccggcgtcaa cgacgacgac cccgagtccg ggcgcatctg
    17401 ggtctcgggc tacgtcgtcc gcgagcccgc ccgcgtcgcc tccaactggc gcgcccggcg
    17461 cacgctggac gaggagctgc agcgccagga cgtcgtgggc atcgcgctgg acggcacccg
    17521 cgccctaacc cgccacctgc gcgaccgcgg cgccatgcgg gccgccatca gcaccgtcga
    17581 gaccgacccc gagcggctgc gcgagcgcgt cctggccagc ccgcagatgg ccggcgcgga
    17641 cctggccggc gaggtcacca cgaccgagcc ctacaccgtc cgcccgcccg agggcgtgcc
    17701 cgcccgcttc cgcgtcgccg ccgtcgatct cggcatcaag gcgatgacgc cccagcgcct
    17761 ggccgagcgc ggctgcgaag tcaccgtgct gcccgccgac accaccgccg aggcgatcct
    17821 cgccctggag cccgacggcg tgttcttcag caacggcccc ggcgaccccg cgaccgccga
    17881 gaaaccggtg gccctgatgc gcgccgtgct ggagtcgcgc accccgctgt tcggtatctg
    17941 cttcggcaac cagatcctgg gccgcgcact ggatctgggc accttcaagc tgcccttcgg
    18001 ccaccgcggc gtcaaccagc cggtgcagga cgtgcacacc aagcgggtgc acatcaccag
    18061 ccacaaccac ggcttcgccg tcgacgcacc cgccgacggg cccttcgaga ccccctacgg
    18121 tcgcgccgag gtcagccacg tcgacctcaa cgacaacgtc gtcgaaggcc tgcggctgct
    18181 cgaccggccc gccttcagcg tccagtacca ccccgaggcc gccgccggac cgcacgacgc
    18241 cgccgcgcac ttcgacgcgt tctgcgacct catggccgcc tcatccgacc cgtccagcag
    18301 ctccggccgg ccggccgagc ccgtccagtc gtaagccggg ggatccacac atgccgcgcc
    18361 gtagtgacct gaagtccgtc ctcgtgatcg gatccgggcc gatcgtgatc ggccaggccg
    18421 cggagttcga ctactccgga acgcaggcgt gccgcgtgct caaggccgag ggcctgcgcg
    18481 tcatcctggt caactccaat ccggccacga tcatgaccga ccccgagatc gccgacgcca
    18541 cctacgtcga gccgatcacc ccggggatgg tcgagaagat catcgccaag gagcgccccg
    18601 acgcgctgct gcccaccctg ggcgggcaga ccgcgctcaa caccgccgtc gcgctgcacg
    18661 actcgggcgt gctggccaag tacagcgtcg agctgatcgg cgccaacgtc gaggccatcc
    18721 agtccggcga ggaccgcgag accttcaagg gcatcgtcga gcggatcggc ggcgagtccg
    18781 cgcgctcgcg catctgccac acgctcgatc agtgcctgga ggcggccgag gagctgagct
    18841 acccggtcgt ggtccggccc tccttcacca tgggcggctc cggctccggc ttcgcccacg
    18901 acgagaagca gctgcgccgc atcgccggcc aggggctcgc gctctcgccg gtcaccgagg
    18961 tcctgctgga ggagtccatc ctcggctgga aggagtacga gctggagctg atgcgcgacg
    19021 gcaacgacaa cgtggtcgtc gtctgctcca tcgagaactt cgaccccatg ggcgtgcaca
    19081 ccggcgactc cgtcacggtg gcgccggcca tgacgctgac cgaccgcgag taccagcaca
    19141 tgcgcgacgt gggtatcgcg gtcatccgcg aggtcggcgt cgacaccggc ggctgcaaca
    19201 tccagttcgc cgtgcacccc gagaccgggc ggatgatcgt catcgagatg aacccgcgcg
    19261 tctcccgctc ctcggcactg gcctccaagg ccaccgggtt ccccatcgcc aagatcgctg
    19321 ccaagctcgc cgtcggctac accctcgacg agatccccaa cgacatcacc gccgagaccc
    19381 cggccagctt cgagccgagc ctcgactacg tcgtggtcaa ggtgccgcgg ttcgccttcg
    19441 agaagttccc cggtgccgac ccggcgctga ccaccacgat gaagtcggtc ggcgaggcca
    19501 tggccatcgg ccgctccttc cccgaggcgc tgcagaaggc catgcgctcg gtggagaaga
    19561 acggcgtcgg cctcacctgg gccggcgagc ccggcgacaa ggacgagctg gtgcgggcgt
    19621 cggccacccc tggcgagctg cggctgcgcc gcatgcagca ggcgctgcgc gccggcgcca
    19681 ccgtggccga gctgaacgcc tccaccggaa tcgacccctg gttcctcgac cagctgctgc
    19741 tgctggagga gaccgcccgc gagctggccg gcggccggct cgacgccggg cggctgcgcg
    19801 cggccaagcg catcggcttc tccgacctgc agatcggcga gatcaccggc aagagcgaag
    19861 aggtggtgcg cgagctgcgc tacgcgctgg gcgtccaccc ggtctatctg accgtcgaca
    19921 cctgcgccgc cgagttcgcc gcccagacgc cctacctgta ctccagctac gacgaggaga
    19981 ccgaggtccc caagggcacc cgccccaagg tcgtcatcct ggggtcgggc cccaaccgca
    20041 tcggccaggg cgtcgagttc gactacagct gcgtgcacgc ctccttcgcg ctgtcggagg
    20101 cgggctacga gaccgtcatg gtcaactgca accccgagac cgtctccacc gactacgaca
    20161 ccagcgaccg cctctacttc gagccgctga ccctggagga cgtgctggag gtcgtccgcg
    20221 ccgagcgcgc caccggcgag gtggccggcg tcgtcgtcca gctcggcggc cagacgccgc
    20281 tggggctggc gcgcggcctc aaggcggccg gggtgcccat cgtcggcacc agccccgagg
    20341 ccatcgacct cgcggaggac cgcggcgagt tcggcaaggt gctggccggc gcggggctgc
    20401 ccgcacccaa gcacggcacc gcccactcct tcgccggagc ccgcgaggtc gccgccgaga
    20461 tcggctaccc cgtgatggtg cgcccctcct acgtgctggg cgggcgcggc atggagatcg
    20521 tctacgacga ggcgatgctg gccgactaca tcgagcgcaa cgccgaagtg agcccggact
    20581 atccggtgct catcgaccgg ttcctcgacg acgccatcga gatcgacgtc gacgccgtct
    20641 acgacggcac cgacctctac ctcggcggga tcatggagca catcgaggag gccggcatcc
    20701 actccggcga ctccgcctgc gccctgccgg cggtgacgct gggccgcgag gacttcgagc
    20761 gcatccgcta ctccaccgag gccatcgccc gcggcaccgg ggtgcgcggg ctgctgaacg
    20821 tgcagtacgc gctcgcctcg ggcgtcctct acgtcctgga ggccaacccc cgcgcctcgc
    20881 gcaccgtgcc gttcgtctcc aaggcgaccg ccgttccgct ggccaaggcc gccgcgcggg
    20941 tgatgctggg cgcgaccgtg cccgagctgc gggccgaggg cctgctgccg gccgagggcg
    21001 acggcggcac gctgcccatg gacgcccccg tctcggtcaa ggaggcggtg ctgcccttca
    21061 accgcttcat c
//
