LOCUS       NZ_CP036455            10417 bp    DNA     circular CON 23-OCT-2024
DEFINITION  Streptomonospora litoralis strain M2 chromosome, complete genome.
ACCESSION   NZ_CP036455
VERSION     NZ_CP036455.1
KEYWORDS    RefSeq.
SOURCE      Streptomonospora litoralis
  ORGANISM  Streptomonospora litoralis
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Nocardiopsidaceae; Streptomonospora.
REFERENCE   1  (bases 1 to 5724192)
  AUTHORS   Khodamoradi,S., Hahnke,R.L., Kaempfer,P., Schumann,P., Rohde,M.,
            Steinert,M., Luzhetskyy,A., Wink,J. and Ruckert,C.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-FEB-2019) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8; canu v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 186.3x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004323735.1-RS_2024_10_23
            Annotation Date                   :: 10/23/2024 04:24:23
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,076
            CDSs (total)                      :: 5,002
            Genes (coding)                    :: 4,957
            CDSs (with protein)               :: 4,957
            Genes (RNA)                       :: 74
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 46
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 46
            Pseudo Genes (frameshifted)       :: 6 of 46
            Pseudo Genes (incomplete)         :: 39 of 46
            Pseudo Genes (internal stop)      :: 2 of 46
            Pseudo Genes (multiple problems)  :: 2 of 46
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 14:19:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 564647
            Orig. end                         :: 575064
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036455.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10417
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="2"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10417
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10417
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5417](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5417
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    488..504
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.53"
                     /tool="antismash"
     gene            complement(796..1485)
                     /locus_tag="EKD16_RS02535"
                     /old_locus_tag="EKD16_02590"
     CDS             complement(796..1485)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017538763.1"
                     /locus_tag="EKD16_RS02535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02590"
                     /product="copper resistance CopC family protein"
                     /protein_id="WP_131096902.1"
                     /transl_table=11
                     /translation="MKHDTSATAPVPTTSAPAARHAPPLRRAAAVAAGLLGSLLLATAT
                     APVALAHDTLLSSSPQDGAELDTAPGEVVLTFSGDIGDGGNAIVVTGPGGEQHQDGEVA
                     IDGPEATVPLQELPTAGEYTVAYRMVSSDGHALEDELAFSITEEAVPEPSPSPSPEEAS
                     PVGGAGDAGEASAEESPAAETPADPMSSLGPIGGVIGAIAVIALIAILIIRMRNRPGGG
                     NGEGGGD"
     gene            complement(1924..2190)
                     /locus_tag="EKD16_RS02540"
                     /old_locus_tag="EKD16_02595"
     CDS             complement(1924..2190)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017538765.1"
                     /locus_tag="EKD16_RS02540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02595"
                     /product="WhiB family transcriptional regulator"
                     /protein_id="WP_131096903.1"
                     /transl_table=11
                     /translation="MNRLYHDSEDWVAQGACRQYDPELFFPVSTTGPGQSDAELAKAIC
                     RTCAVRAECLNWALRAGEPHGVWGGTTPEDRRYMRRQPLPMAS"
     misc_feature    complement(2609..2626)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.99"
                     /tool="antismash"
     misc_feature    complement(2876..2894)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.17"
                     /tool="antismash"
     misc_feature    complement(2900..2914)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            2906..3538
                     /gene="ectA"
                     /locus_tag="EKD16_RS02545"
                     /old_locus_tag="EKD16_02600"
     CDS             2906..3538
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017542311.1"
                     /locus_tag="EKD16_RS02545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02600"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_242677203.1"
                     /transl_table=11
                     /translation="MPDQQTDDDTSAALGSGDHPAVVGDPAASDGISMREPALADGPEL
                     WRLARDSGLDINSPYAYTLWSRDFAATSVIARDADGRPRGFVTGFVRPSAPDTYFLWQV
                     GVDPGFRGRRLARRMLDHIGDRIAERGLTYLEATVTPDNTASRALFSSFARDRDCEAVW
                     SPLFEREHFPADESEGHEPEDLVRIGPLGRPDSDRSTAADTTPDTRS"
     gene            3606..4871
                     /gene="ectB"
                     /locus_tag="EKD16_RS02550"
                     /old_locus_tag="EKD16_02605"
     CDS             3606..4871
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_function="GO:0047307 - diaminobutyrate-pyruvate
                     transaminase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (22-355). E-value: 1e-73.
                     Score: 240.2. Matches aSDomain:
                     nrpspksdomains_EKD16_RS02550_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017558126.1"
                     /locus_tag="EKD16_RS02550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02605"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_131096904.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.4e-72, bitscore:
                     241.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIFERLESEVRSYCRSWPVVFNEARGSYIYDESGRPYLDFFAGA
                     GSLNYGHNHPELKSKLIDYLMSDAIVHSLDAYSSAKRDFLATFGETILGPRGLDYKVQF
                     PGPAGNNAVEAALKLARKYTGRETVISFTNGFHGMTLGALAVTGNSMKRGGAGVPLSHS
                     ATMPFDKYMDGQTPDFLWLRSLLEDSGSGLDAPAAVIVETVQGEGGINVASAEWLRGLQ
                     EVCHEYDMLLIVDDIQMGCGRTGPFFSFEQAGITPDVVTMSKSISGYGIPMALTLIKRE
                     LDVWDPGEHNGTFRGPNPAFVTGAEAMRLFWSDDSLQKATEAKGQLIDRHLRAIAEELG
                     SEEASVRGRGMARGLVLEREGAAKVLSREAFERGLLLETSGPEDEVAKLLPALTTTEQE
                     LEQGLEILADAARAAMKAPQHA"
     aSDomain        3672..4670
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKD16_RS02550_Aminotran_3.1"
                     /evalue="1.00E-73"
                     /label="EKD16_RS02550_Aminotran_3.1"
                     /locus_tag="EKD16_RS02550"
                     /protein_end="355"
                     /protein_start="22"
                     /score="240.2"
                     /tool="antismash"
                     /translation="NEARGSYIYDESGRPYLDFFAGAGSLNYGHNHPELKSKLIDYLMS
                     DAIVHSLDAYSSAKRDFLATFGETILGPRGLDYKVQFPGPAGNNAVEAALKLARKYTGR
                     ETVISFTNGFHGMTLGALAVTGNSMKRGGAGVPLSHSATMPFDKYMDGQTPDFLWLRSL
                     LEDSGSGLDAPAAVIVETVQGEGGINVASAEWLRGLQEVCHEYDMLLIVDDIQMGCGRT
                     GPFFSFEQAGITPDVVTMSKSISGYGIPMALTLIKRELDVWDPGEHNGTFRGPNPAFVT
                     GAEAMRLFWSDDSLQKATEAKGQLIDRHLRAIAEELGSEEASVRGRGMARGL"
     misc_feature    4995..5011
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 21.78"
                     /tool="antismash"
     gene            5001..5417
                     /locus_tag="EKD16_RS02555"
                     /old_locus_tag="EKD16_02610"
     CDS             5001..5417
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011290749.1"
                     /locus_tag="EKD16_RS02555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02610"
                     /product="ectoine synthase"
                     /protein_id="WP_131096905.1"
                     /sec_met_domain="ectoine_synt (E-value: 1.1e-53, bitscore:
                     178.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSLTDVDGTDADIRTETWRSRRVVLAKDKVGFSFHETVLYAG
                     TETRMWYANHIELVHCIEGEAEVTDEETGETHLITPGTLYLLDGHEHHTVRPKTDFRVL
                     CVFNPPVTGREVHDEHGVYPLLSETGERLDTPGQ"
     misc_feature    complement(5615..5630)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     gene            5635..6543
                     /gene="thpD"
                     /locus_tag="EKD16_RS02560"
                     /old_locus_tag="EKD16_02615"
     CDS             5635..6543
                     /EC_number="1.14.11.55"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621331.1"
                     /locus_tag="EKD16_RS02560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02615"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_131096906.1"
                     /sec_met_domain="PhyH (E-value: 1e-31, bitscore: 109.0,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALTTHIEQPTMDDYPTRKDHTPALLYRKDPTFWGDRGSGPLDA
                     ATAESYEANGYLQIESLITADELESCRGELDRLSGDEELKNDERVVVERSCDEVRSIFE
                     VHEISGVFGELVRDPRIVDRARQILGSDVYIHQSRVNSKPGFSGTDFFWHSDFETWHAE
                     DGMPRMRAVSISIALSDNYEHNGSLMIMPGSHKTFVSCVGETPDDHYRESLKKQQIGTP
                     DQSSLSILADQNGIDVMTGPAGGAIMFDSNCMHGSNGNITPFPRANVFVVYNSVENTCE
                     TPFAAPQRRPYFLGARDFTPV"
     misc_feature    complement(6629..6646)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.82"
                     /tool="antismash"
     gene            6880..7794
                     /gene="ehuB"
                     /locus_tag="EKD16_RS02565"
                     /old_locus_tag="EKD16_02620"
     CDS             6880..7794
                     /GO_component="GO:0030288 - outer membrane-bounded
                     periplasmic space [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033294 - ectoine binding [Evidence IEA]"
                     /GO_function="GO:0033295 - hydroxyectoine binding [Evidence
                     IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017558128.1"
                     /locus_tag="EKD16_RS02565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02620"
                     /product="ectoine/hydroxyectoine ABC transporter
                     substrate-binding protein EhuB"
                     /protein_id="WP_131096907.1"
                     /transl_table=11
                     /translation="MSNSSPLGHLGRRDVLRAGGITAAALAAGPGLAACSRTEPAQGQT
                     LLESLREKGSIKAAINNEPPFGYIDDNGKVTGEAPELLRAIVKEMGIDKIEAETVSWDG
                     LIPGLKAGRYDVVAAGMYITPERCQEVAFAEPDYKVLEAFMVKKGNPKNLETYHSVAEQ
                     PDVQIAVLNASVEQNYAEGAGVKKDQMTLGDNAVQMLDLLENGRVDAVGLSTFSLNYQM
                     EQRGMQGGYEVTEGFTPVVDGEEVKPAGGFAFRKENQDFLDRFNEVLADFKQSGRLTEI
                     GKEFGFDEAAHPGDLTTEELCSQ"
     gene            7817..8542
                     /gene="ehuC"
                     /locus_tag="EKD16_RS02570"
                     /old_locus_tag="EKD16_02625"
     CDS             7817..8542
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuC"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013156203.1"
                     /locus_tag="EKD16_RS02570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02625"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuC"
                     /protein_id="WP_131096908.1"
                     /transl_table=11
                     /translation="MDFFLNRFPAYLDGALTTLMLTLLGSLLAFILAMVIGILGTLRNP
                     LARGIATVYTEAFRGVAALILLFWFAYAVPQITPYQLSPIFAGVLALGLNVGAYGAEVV
                     RAAINAVPRAQTEATIALNMSWARRMWLVLLPQAWAQMLPTFGNLIIELMKASAIVSLI
                     NVADLTDVAGTLRQSTGETIPAFVSALIMYFVIAQVLILGMRMLERQANRRLGRAPTGG
                     GLLSLLRPPTPGTRVGAAK"
     gene            8539..9177
                     /gene="ehuD"
                     /locus_tag="EKD16_RS02575"
                     /old_locus_tag="EKD16_02630"
     CDS             8539..9177
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuD"
                     /gene_functions="transport (smcogs) SMCOG1096: polar amino
                     acid ABC transporter, inner membrane"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017538772.1"
                     /locus_tag="EKD16_RS02575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02630"
                     /product="ectoine/hydroxyectoine ABC transporter permease
                     subunit EhuD"
                     /protein_id="WP_131096909.1"
                     /transl_table=11
                     /translation="MTWDTEFAISIIPQLLQGLVVTVQAVVIGYAVALVLGLFVAVLRM
                     VRGVGPVVFAVFEFIRTTPILVQLLFVFALAPPSITPLTIGVSVLGVHYAAYTAEVYRS
                     GIEGVAKGQWEACRALSLPPVRTWGAVVLPQAIRKVVPALGNYLISMFKDTPYLFAITV
                     PEMMFVAKAIGTESFRSMEAYTLAGLFFLAVSVPSAVIIRRLERRYAAV"
     gene            9164..10000
                     /gene="ehuA"
                     /locus_tag="EKD16_RS02580"
                     /old_locus_tag="EKD16_02635"
     CDS             9164..10000
                     /GO_component="GO:0009898 - cytoplasmic side of plasma
                     membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0033286 - ATPase-coupled ectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_function="GO:0033288 - ATPase-coupled hydroxyectoine
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0033308 - hydroxyectoine transmembrane
                     transport [Evidence IEA]"
                     /GO_process="GO:0051470 - ectoine transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ehuA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017590341.1"
                     /locus_tag="EKD16_RS02580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKD16_02635"
                     /product="ectoine/hydroxyectoine ABC transporter
                     ATP-binding protein EhuA"
                     /protein_id="WP_131096910.1"
                     /transl_table=11
                     /translation="MQQSDSTRSTETAGVQSAQEAPGGEIINFDKVVKRYGSNVVLDEL
                     DFSVAPGERVTLIGPSGSGKTTILRLLMTLEPIDGGVIWVNGEPLSHMRRGGRLVKANE
                     AHLRRARKSIGMVFQQFNLFPNMSVRKNVTEGPVHSLGVAKDEANRRAEELLDMVGLSD
                     KIDAHPTQLSGGQQQRVAIARALAMQPQILLLDEVTSALDPELVAGVLDVLREIAQSTD
                     ITMLCVTHEMSFARDVSHRVLMFDEGQVAEEGSPERIFGDPQEERTKTFLKAVLES"
     misc_feature    complement(10198..10213)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.82"
                     /tool="antismash"
     misc_feature    complement(10199..10208)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: medium, score: 16.86"
                     /tool="antismash"
ORIGIN
        1 ggcagcgacg aaggcgcggt gcacgggctg tggcaggccg ccatggaggg ctcgggccgc
       61 gacaacatca gcatcctgct ggcccgccgc gtctgagatg agtgagtccg atgtcttcgg
      121 tcgccggagg cggctcgggt ctgcagggcg gccttgcggg tctgccgggc ggcgggcggt
      181 ctgcaggaga agcggcggcg acggcggcag tggggcgggc ccgcgcccac cgggccgggt
      241 gcccgccggt tgggcgcccg gcgccgcgcc gagcctggct ctagggacgt ctcggcgccg
      301 aaagtgtccc tgaagtaagg ctcggtgagg atcgggtgcc cgcgtgtccg ttgtgccggg
      361 gttcgcgggg gccgagccgg accagagcgc tgcggtgcgg gatcgggcac ggccgggcgc
      421 gcgtatccat cgagtgcgcg gaaatcacca cacacaggcc cggatgtggt gatttccgcg
      481 cgctcgatgc agcggaaacc ggcatagccg acattgcgac atctgttccg tcgtcgggcg
      541 caccaccggc gcccaccggc accggtgggc gcgggcccgg ccgtccgccg ccgtcgccgc
      601 ttttcggttc aggcggcccg acacccgccc ggtgccaagg ccgtacagca gacccggggc
      661 gctcccaggc gctaccgagc cgaccgtctg ggcaacctgc tcagacatcg gactcactca
      721 tctgaggcgt ccgacgcggc gcacaccgtc ggaacccgga caaccccgtc ggccggagac
      781 cgggccggag ccgcgtcagt ctccgccgcc ctcgccgttt ccgccgccgg ggcggttgcg
      841 catccggatg atcaggatgg cgatcagcgc gatgacggcg atcgcgccga tcacgccgcc
      901 gatcggaccc agcgaggaca tcgggtcggc cggcgtctcg gccgcggggg actcctcggc
      961 cgacgcctcc ccggcgtccc cggcgccgcc gacgggcgag gcctcctcgg ggctgggcga
     1021 gggactcggc tcgggcacgg cctcctcggt gatggagaag gccagttcgt cctccagcgc
     1081 gtggccgtcg gaggagacca tccgataggc gacggtgtac tcgccggcgg tcggcagctc
     1141 ctgcagcggg acggtcgcct cgggcccgtc gatcgcgacc tcgccgtcct ggtgctgctc
     1201 gccgccgggc ccggtgacca cgatcgcgtt gccgccgtcg ccgatgtcgc cgctgaaggt
     1261 cagcaccacc tcaccgggcg cggtgtcgag ctcggcaccg tcctgcggcg aggaggagag
     1321 gagggtgtca tgggccagcg caacgggtgc cgtcgcggtc gcgaggagca gtgatcccag
     1381 gagtccggcg gcgaccgccg ccgcgcgccg cagcggcggg gcgtgccgtg cggcaggcgc
     1441 cgacgtggtg gggacgggcg cggtggcgga tgtgtcgtgc ttcatcggcg ggatcccttc
     1501 gcgggtgggg gatgatcggc gtgcgggagc ggcggttgcg gcctgcggcc cggtcggcgg
     1561 acgtcgccgc aacggcggga cgccggcgcc gggcgtccgg ggcggatccg catgctcgca
     1621 ggggtcgcac ggcttccgaa tctagccgaa tgcggccggg ggcgtccctt cgacagaagc
     1681 gcctcgttgc ggcgatgagg cccggtcagc atccattgcg cggaaatcac cacgtccaag
     1741 gccgttcctt ggcgatttcc gcacaatgga cgccgcgaag cccgacgccc gggcgctcga
     1801 ccatcacttg atgtcaatcg gtggttgcca cgaggtgctc gtcgagggcc tcagcgggcc
     1861 cgagccgcct tgtccgggac gcccccgcct accgccacca gcgacgcacg tgacgaagta
     1921 ctgctaggac gccatcggca gcggctggcg gcgcatgtag cggcggtctt ccggggtggt
     1981 cccgccccag acgccgtggg gttcgccggc gcgcagcgcc cagttcaggc attccgcacg
     2041 caccgcacat gtgcggcaga tggccttggc cagctccgcg tcgctctggc cggggcccgt
     2101 cgtgctgacg gggaagaaga gttcggggtc gtactggcgg catgcgccct gcgcgaccca
     2161 gtcttcgctg tcgtggtaaa gccggttcac caggagcctc cgttccctgg ccggatcccc
     2221 gcgcggggcg gacgcccggg tgccgcgcgg cggacgtgtc tggtcgcgag acggaggact
     2281 ccggtcgccg ctccatcgcg atgcgaccca tcgtagtact acgtgcggtc gtactacgaa
     2341 aagtctgcca aaattctgcg cggcgcttca agccccgctg cggggaggcg ccatccgccc
     2401 ctgcggtcga ctcgtgccac accggccgcc gcgcgtacca ccggccgcta ccccggatcc
     2461 gtgccgcatc ccgcaatcgc ggtcgcgatc accgccatgc ggtgtgtcct ccccggtgcg
     2521 gcctcgcgcg cccccggcgg gcgggcaagc gggcggcccg tggcggccga cgtggtctgt
     2581 cgcgaggatt catccgaatt cgtgtgactt aacgcacgct taaaattcgg tgcgactccc
     2641 cctatgtttg cctggtaaca ggcacaatcg cgtcgggcgc atcccgccgg acgctctccg
     2701 cgcggctccc gggtgccact ccgaacctcc tggtgagctt ggcgtgcacg gcagtctccc
     2761 ggaggccccg cgactcccct cgatgacgac ggaaagtgac gatcggggca aaatagacgt
     2821 gtcatacccg gcgaaacgcg gctgaaacat acggcgttcg gagccgggaa acgctgctca
     2881 ggaacgttcg ctatgttcca tcgacgtgcc tgaccaacag accgacgacg acaccagcgc
     2941 cgcgctcggc tccggcgatc accccgctgt agtcggcgac ccggccgcat ccgacggcat
     3001 cagcatgcgg gagccggctc tcgccgacgg accggaactg tggcggctag cccgcgactc
     3061 cgggctcgac atcaactcgc cctacgccta cacgctgtgg agcagggact tcgccgccac
     3121 cagcgtgatc gctcgcgacg cagacgggcg cccgcgcggt ttcgtcaccg gtttcgtccg
     3181 cccctcggca ccggacacct acttcctgtg gcaggtgggg gtggacccgg gattccgcgg
     3241 acggcggctg gcgcgccgca tgctcgacca catcggcgac cggatcgccg agcgcgggct
     3301 gacctacctg gaggcgacgg tgacgccgga caacacggcc tcccgtgccc tgttctcgtc
     3361 ctttgcccgg gaccgggatt gcgaggcggt gtggagtccg ttgttcgagc gtgagcactt
     3421 ccccgcggac gaaagcgagg ggcacgaacc cgaagacctc gtccggatcg gtccgctggg
     3481 ccggccggac tccgaccgaa gtaccgccgc cgacaccaca cccgacaccc gatcctgacc
     3541 gacccgcccc ccacgcgtca cagccgtgac cccgaaacac ggggaaagga ctcaaggaac
     3601 tcacgatgga gatcttcgaa cgcctcgaat ccgaagtccg cagctactgc cgtagctggc
     3661 cggtcgtctt caacgaggcg cggggcagct acatctacga cgagtcgggg cgaccgtacc
     3721 tcgacttctt cgccggtgcc ggttcgctca actacgggca caatcacccg gagctgaaat
     3781 ccaaactcat cgactacctg atgagcgacg cgatcgtgca cagcctcgac gcgtactcca
     3841 gcgccaaacg cgacttcctg gcgaccttcg gcgaaacgat cctggggccg cgcggactcg
     3901 actacaaggt ccagttcccc ggccccgcgg gcaacaacgc cgtcgaggcg gcgctcaagc
     3961 tcgcccgcaa gtacaccggt cgcgagaccg tcatcagctt caccaacggc ttccacggca
     4021 tgacgctggg ggcgctcgcg gtcaccggca actccatgaa gcgcggcggg gcgggcgttc
     4081 cgctgagcca ctcggccacc atgcccttcg acaagtacat ggacggccag acgcccgact
     4141 tcctctggct ccgcagcctg cttgaggaca gcggcagcgg actggacgca cccgcggcgg
     4201 tgatcgtgga gaccgtgcag ggcgagggcg gcatcaacgt cgccagcgcc gaatggctgc
     4261 gcggcctcca agaggtgtgc cacgagtacg acatgctgct catcgtggac gacatccaga
     4321 tgggttgcgg ccgtaccggc ccgttcttca gcttcgagca ggccgggatc acgcccgacg
     4381 tcgtcaccat gtccaagtcc atcagcggct acgggatccc gatggcgctg acgctgatca
     4441 aacgcgagct cgacgtctgg gacccgggcg agcacaacgg gaccttccgc ggccccaacc
     4501 cggcgttcgt gaccggcgcc gaggcgatgc gcctcttctg gagcgacgac tccctgcaga
     4561 aggccaccga ggccaagggg cagctcatcg accgccacct gcgggcgatc gccgaggagc
     4621 tcgggtccga ggaggccagt gtgcgcggcc gcggcatggc ccggggcctg gtcctggagc
     4681 gcgagggcgc ggcgaaggtc ctcagccgcg aggccttcga gcgcggcctg ctgctggaga
     4741 cctccggtcc cgaggacgag gtggcgaagc tgctgccggc gctgaccacc accgagcagg
     4801 agctggagca ggggctggag atcctggcgg acgccgcccg ggccgcgatg aaggccccgc
     4861 agcacgcctg acttccatca gcaccgggac acgggggatt tccgggcccc acaattggct
     4921 gtgaaggcgc gcggggtccc gggcggcccg cccgggaccc cgccttcggc caaagcgagt
     4981 aagcaagagg agtatgcacc ttgatcgtgc gcagcctgac tgacgtcgac ggcaccgacg
     5041 ccgacatcag gaccgagacg tggcgcagcc gccgcgtcgt tctggccaag gacaaggtcg
     5101 ggttctcgtt ccacgagacc gtcctctacg cgggcaccga gaccaggatg tggtacgcga
     5161 accacatcga actcgtgcac tgcatcgagg gcgaggccga ggtcaccgac gaggagaccg
     5221 gcgagaccca tctcatcacc ccgggcacgc tgtacctcct cgacggccac gagcaccaca
     5281 cggtgcggcc gaagacggac ttccgggtgc tgtgcgtgtt caacccgccc gtcaccggcc
     5341 gcgaggtcca cgacgagcac ggtgtatacc ccctcctgtc cgaaaccggg gaaaggctgg
     5401 acaccccggg tcagtaaggc acgggcgggg tgcggccgcg accgcgcccc gcctgccggg
     5461 gaccggcgtc cgcagcgccg gccccggacc gcggaccgcg gcgcgtgcgc ccgcggcgac
     5521 agggcgctac ggcgccgcgg aaccgggaag tcgcaatcag caaggagacg aaggcgcggc
     5581 ctaccgcacg ccgcgcgaac acgaaaaagg agcgaatccc tcaggggtat ggccatgact
     5641 gcgttgacga cccatatcga gcagccgacc atggacgact acccgacccg caaggaccac
     5701 acgccggccc tgctgtaccg caaggacccc acgttctggg gggaccgcgg gagcgggccg
     5761 ctggacgccg cgacggccga gtcctacgag gcgaacggct atctgcagat cgagtccctg
     5821 atcaccgcgg acgagctgga gtcctgccgc ggcgagctcg accggctcag cggcgacgag
     5881 gagctgaaga acgacgagcg cgtcgtcgtg gagcgttcct gcgacgaggt gcgctccatc
     5941 ttcgaggtgc acgagatcag cggcgtcttc ggcgagctgg tgcgcgatcc gcgcatcgtc
     6001 gaccgggccc gccagatcct gggctccgac gtctacatcc accagagccg agtcaactcc
     6061 aagcccggat tctccggcac cgacttcttc tggcactccg acttcgagac ctggcacgcc
     6121 gaggacggga tgccgcggat gcgcgcggtg agcatctcca tcgcgctcag cgacaactac
     6181 gagcacaacg gctcgctgat gatcatgccg ggctcgcaca agacgttcgt ctcctgcgtg
     6241 ggcgagaccc ccgacgacca ctaccgcgag tcgctcaaga agcagcagat cggcacgccc
     6301 gaccagtcga gcctgtccat cctggccgac cagaacggca tcgacgtgat gaccgggccg
     6361 gccggcgggg ccatcatgtt cgactccaac tgcatgcacg gctccaacgg caacatcacg
     6421 ccgttccccc gcgcgaacgt gttcgtcgtc tacaacagcg tcgagaacac ctgcgagacc
     6481 ccgttcgcgg cgccgcagcg gcggccgtac ttcctgggcg cccgcgactt cacaccggtg
     6541 tgatcgccgg atgacaagct gacaacgagg cgaagctagg acattcgtga ctcgatcggt
     6601 acggggccgg agtcggccat gtacccgggt aaccagtgca taacgtgcta ttccgccccc
     6661 gttagccctg agcgatcatg ggcacggagt tgtgcacagg cgccggttgg tgccgggcga
     6721 cccgcgtgac cgggggtact gagacgaccc gatccctgct ttcgaccggg gcttgtctca
     6781 gggccacgca tgtccgtacc accgcacggc gcttcctccc cgcgagggag ggagcgccgc
     6841 gctgttcccc ccttagtttc gcgacgagga gatagagcaa tgagcaacag cagtcccctg
     6901 ggtcacctcg gccgccgcga tgttctgcgc gcgggcggca tcaccgccgc cgcgctggcc
     6961 gcgggtccag ggctggccgc gtgctcccgc accgagcccg cacaagggca gacgctgctg
     7021 gagagcctgc gcgagaaggg ctcgatcaag gcggcgatca acaacgagcc ccccttcggc
     7081 tacatcgacg acaacggcaa ggtcacgggc gaggcgcccg agctgctgcg ggcgatcgtc
     7141 aaggagatgg gcatcgacaa gatcgaggcc gagacggtca gctgggacgg cctgatcccc
     7201 ggcctgaagg cgggccgcta cgacgtcgtc gcggccggca tgtacatcac accggagcgc
     7261 tgccaggagg tggccttcgc cgagccggac tacaaggtgc tcgaagcgtt catggtgaag
     7321 aagggcaacc cgaagaacct ggagacctac cactccgtcg cggagcagcc cgacgtgcag
     7381 atcgccgtgc tcaacgcctc ggtcgagcag aactacgccg agggcgcggg cgtcaagaag
     7441 gaccagatga cgctcggcga caacgccgtg cagatgctcg acctgctgga gaacggccgt
     7501 gtcgacgcgg tcggcctgag caccttctcg ctgaactacc agatggagca gcgcggcatg
     7561 cagggcggct acgaggtgac cgagggcttc actcccgtgg tcgacggcga ggaggtcaag
     7621 cccgccggcg gcttcgcctt ccgcaaggag aaccaggact tcctggacag gttcaacgag
     7681 gtcctggccg acttcaagca gagcggtcga ctgaccgaga tcggcaagga gttcggcttc
     7741 gacgaggcgg cccacccggg cgacctgacc accgaagaac tctgctcgca gtagcggcta
     7801 ggtcgagggt tcttccgtgg atttcttcct caacaggttc ccggcctatc tggacggggc
     7861 cctgacaaca ctgatgctga ccctgctggg ctcgctgctg gcgttcatcc tggcgatggt
     7921 gatcggcatc ctcggcacgc tgcgcaaccc gctggcccgc gggatcgcca cggtatacac
     7981 cgaggcgttc cgcggtgtcg cggcgctgat cctgctgttc tggttcgcct acgcggtccc
     8041 gcagatcacg ccgtatcagc tctcaccgat cttcgcgggc gtgctcgcgc tcgggctgaa
     8101 cgtcggtgcc tacggcgccg aggtggtgcg tgcggcgatc aacgcggtgc ccagggcgca
     8161 gaccgaggcc acgatcgcgc tgaacatgtc gtgggcgcgg cggatgtggc tggtgctgct
     8221 gccgcaggcg tgggcgcaga tgctgccgac cttcggcaac ctgatcatcg agttgatgaa
     8281 ggcgtcggcg atcgtatcgc tgatcaacgt cgccgatctc accgacgtcg ccggcactct
     8341 gcggcagagc accggggaga cgatcccagc cttcgtcagc gccctgatca tgtacttcgt
     8401 catcgcccag gtgctgatcc tcgggatgcg catgctggag cgccaggcca accggcggct
     8461 gggcagggcg ccgaccggcg gtggcctgct gtccctgctg cgtccgccga cacccggaac
     8521 gagagtgggg gcggccaagt gacctgggac accgagttcg cgatcagcat catcccgcaa
     8581 ctgctgcaag ggttggtcgt caccgtccaa gcggtggtga tcggctatgc ggtggccctc
     8641 gtcctgggcc tgttcgtggc ggtcctgcgc atggtccggg gcgtcggtcc ggtggtgttc
     8701 gccgtcttcg agttcatccg gaccaccccg atcctggtgc agctgctgtt cgtgttcgcc
     8761 ctggcaccgc cgagcatcac gccgctgacg atcggcgtct cggtcctggg cgtgcactac
     8821 gcggcctaca ccgccgaggt ctaccgctcg gggatcgaag gtgtggccaa gggccagtgg
     8881 gaggcctgcc gcgcgctgag cctgccaccg gtgcggacat ggggcgccgt cgtgctgcct
     8941 caggccatcc gcaaggtcgt gcccgccctg ggcaactacc tcatctccat gttcaaggac
     9001 acgccgtacc tgttcgccat caccgtgccc gagatgatgt tcgtggccaa ggcgatcggc
     9061 accgagtcct tccgcagtat ggaggcctac accctcgcag ggttgttctt cctggccgtg
     9121 agcgtgccct ccgcggtcat catccgacgt ctggagcgcc gatatgcagc agtctgacag
     9181 tacgcggagt acggagaccg ccggcgtgca gtccgctcag gaggcacccg gcggcgagat
     9241 catcaacttc gacaaggtcg tcaagcgcta cggcagcaac gtggtgctcg acgagctgga
     9301 cttctcggtc gcccccggtg agcgggtaac gctcatcggg cccagcgggt cgggcaagac
     9361 gacgatcctg cgcctgctga tgaccctgga gcccatcgac ggcggcgtca tctgggtcaa
     9421 cggcgagccg ctgtcgcaca tgcgccgcgg agggcgcctg gtcaaggcca acgaggccca
     9481 cctgcgccgc gcgcgcaaga gcatcggcat ggtcttccag cagttcaacc tcttcccgaa
     9541 catgagcgtg cgcaagaacg tcaccgaggg tcccgtgcac agcctgggcg tggccaagga
     9601 cgaggccaac cggcgcgccg aggagctgct ggacatggtc gggctgagcg acaagatcga
     9661 cgcccacccc acccaactgt ccggcgggca gcagcagcgc gtggcgatcg cgcgggcgct
     9721 ggccatgcag ccgcagatcc tgctgctgga cgaggtcacc tcggcgctcg accccgaact
     9781 ggtcgccggg gtgctggacg tgctgcggga gatcgcgcag agcaccgaca tcaccatgct
     9841 gtgcgtgacc cacgagatga gcttcgcccg ggacgtgtcg caccgggtgc tgatgttcga
     9901 cgaaggccag gtcgccgagg agggttctcc cgagcggatc ttcggcgacc cgcaggagga
     9961 gcgcaccaag acgttcctca aggcggtgct cgaaagctga cgccggctgc cggtgcggtc
    10021 ccccttttcg ccggggtcgg cgccggtccg attcacagtg cgggagggtg ctccgacggg
    10081 gcgccctccc gtcgctttgc ccgcggcccg cggcccgtgc ccggcgggtg acggcttccg
    10141 tgacgccccg acgggcgcgc ggcgccgcat cgccaactcg actttcctct gcggaaagta
    10201 aaaaaacgga gagtaacgac ataccgtttc cattgcgtca cctttccctg cgtacaggag
    10261 agactgaggc cctgagctgg ggggaggccg gtgacgagaa catccggacg gttactgaag
    10321 tggggcgccg ccgcggcggt gacggccttg gccgtggtgc tggtgctgca ccccgtggtg
    10381 ccgacgagtg cgctcggggg gcgggcgccg agccacg
//
