LOCUS       NZ_CP036402            24337 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Egibacter rhizosphaerae strain EGI 80759 chromosome, complete
            genome.
ACCESSION   NZ_CP036402
VERSION     NZ_CP036402.1
KEYWORDS    RefSeq.
SOURCE      Egibacter rhizosphaerae
  ORGANISM  Egibacter rhizosphaerae
            Bacteria; Actinomycetota; Nitriliruptoria; Egibacterales;
            Egibacteraceae; Egibacter.
REFERENCE   1  (bases 1 to 4637169)
  AUTHORS   Chen,D.-D., Tian,Y., Jiao,J.-Y., Zhang,X.-T., Zhang,Y.-G., Zhang,Y.,
            Xiao,M., Shu,W.-S. and Li,W.-J.
  TITLE     Egibacter rhizosphaerae EGI 80759T
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4637169)
  AUTHORS   Chen,D.-D., Tian,Y., Jiao,J.-Y., Zhang,X.-T., Zhang,Y.-G., Zhang,Y.,
            Xiao,M., Shu,W.-S. and Li,W.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-JAN-2019) School of Life Sciences, Sun Yat-Sen
            University, 135 Xingang West Road, Guangzhou 510275, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 99.52x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004322855.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 04:33:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,252
            CDSs (total)                      :: 4,199
            Genes (coding)                    :: 4,154
            CDSs (with protein)               :: 4,154
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 45
            CDSs (without protein)            :: 45
            Pseudo Genes (ambiguous residues) :: 0 of 45
            Pseudo Genes (frameshifted)       :: 11 of 45
            Pseudo Genes (incomplete)         :: 36 of 45
            Pseudo Genes (internal stop)      :: 3 of 45
            Pseudo Genes (multiple problems)  :: 5 of 45
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:53:36
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2800104
            Orig. end                         :: 2824441
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP036402.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24337
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="8"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     cand_cluster    1..24337
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24337
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:14337]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14337
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     gene            669..1724
                     /locus_tag="ER308_RS13060"
                     /old_locus_tag="ER308_13060"
     CDS             669..1724
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014381.4"
                     /locus_tag="ER308_RS13060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13060"
                     /product="NAD/NADP octopine/nopaline dehydrogenase family
                     protein"
                     /protein_id="WP_240732100.1"
                     /transl_table=11
                     /translation="MVAVLGGGNGAHAAVVDLQLKGYRVAWWRRDAGAFPPDGCLRYTG
                     ILGEGEITVERCTDVLAEAVEDADLVVAPLPADAQPPLLDRLAPALRDGQAVAFTPGTF
                     GSWLGAQRRPGVTFLETGTLPYLARVTAPGEVSIPVVATRLPTGSIPGEGPAADAAHEA
                     FAAAYPSAVRVSDGWDAALCNWGPVLHPPLIVQNLGAIESLGDAFDIHAAGTSEGVVRT
                     ILAVDEERIALRRTLNLPGEHWPIRTHYDESPQGMYGSDAKRRLVESGLWRERLHPRHR
                     YVTEDLLCGLVLTASWGRAAGQPMPVSEALLTLAAPSLGVDPWTEGRSAASIGAEDLEV
                     LRAAARHGGGR"
     gene            1721..2317
                     /locus_tag="ER308_RS13065"
                     /old_locus_tag="ER308_13065"
     CDS             1721..2317
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0031317 - tripartite ATP-independent
                     periplasmic transporter complex [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015740 - C4-dicarboxylate transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016200.4"
                     /locus_tag="ER308_RS13065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13065"
                     /product="TRAP transporter small permease"
                     /protein_id="WP_131155400.1"
                     /transl_table=11
                     /translation="MSSEAAARGGLDERVDRVSRRANGALATLAAIAVLSIMLLTVVNM
                     VLRFAGAPIAGSFELVGWLAALTNGLAVGYTQTRRGHVDIDVLTRLMPLRIQAVLRAVM
                     TGVATGFFVIVTWQLVEHGLHLRDVGSLSDVLRVPFYPFTFAVAVGFAGFVLALFADLL
                     RHGREAMVPRREGDRTGWTGTATDMADDDGSEGRE"
     gene            2314..3603
                     /locus_tag="ER308_RS13070"
                     /old_locus_tag="ER308_13070"
     CDS             2314..3603
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0031317 - tripartite ATP-independent
                     periplasmic transporter complex [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018513.4"
                     /locus_tag="ER308_RS13070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13070"
                     /product="TRAP transporter large permease"
                     /protein_id="WP_131155401.1"
                     /transl_table=11
                     /translation="MSDLAIAGIGVVAMLALMLLRMPVAFAMMIVGFVGAMVVLTPDAA
                     LQLISADVWNQLSAFSLSVIPMFVLMGQVAYRSGITQRLYETAYNWLGHLPGGVAATTI
                     LASMGFAMVSGSNTATTATMGTVALPEMRRYGYARSLASSSVAMGGTLGVVIPPSVVLI
                     VIAIQAELSIGRLFVAAIAPGIMLTIMLLLTVVVLCRLRPELGPPSEKASWGQRLGSLG
                     GVIETLVLFALVIGGLYLGWFTPTESGAIGAFGAFVIGFARRNLNWEQIKLATLETLRI
                     SAMVILLLAGAVVISRFLTVTRLPFELAEWAADVAVDPLWMLLMVLLIYLIGGLIMDAL
                     GFLVATIPIFFPLALALDFNPIWFTLLITLVTSLGAVTPPVGVNVYIVSSLDPDLGVVE
                     VFRGVLPFMLSYVLVIALLIAFPGIALFAL"
     gene            3637..4707
                     /locus_tag="ER308_RS13075"
                     /old_locus_tag="ER308_13075"
     CDS             3637..4707
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012993.4"
                     /locus_tag="ER308_RS13075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13075"
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_131155402.1"
                     /transl_table=11
                     /translation="MIQPYSAVGLIPTVRGIRTRDDIQRNLDHLAELVTAASWLSSMDL
                     PVRLVIVPEGALQGFNDEVLDLHHETFARECAIDLPGKETEFLGDLARKWGVYLMAQAK
                     VRHPEFPGRFFNAGFVLDPQGELILIHYKVVPLLPVEHSVTPHNVWDRWVELYGETLDA
                     FYPVVDTDIGRLGVMMANEGSYPENARGLAMNGAEVVYRASYPHPHTGNELFEVQNRAR
                     ALDNNFYVLAPNMGTYYLHAEDELPIDTFGGRSMMCDYKGRVVGQQDYGAGSTYIAGQI
                     DVEALRDFRTRAQMNNWMKDLTTEQYRLIYDQPVYPKNLYLDREPYDHADYKAQVTDRQ
                     IEYLVERDIYRWPEGR"
     gene            4766..5233
                     /locus_tag="ER308_RS13080"
                     /old_locus_tag="ER308_13080"
     CDS             4766..5233
                     /GO_function="GO:0032559 - adenyl ribonucleotide binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012791.4"
                     /locus_tag="ER308_RS13080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13080"
                     /product="universal stress protein"
                     /protein_id="WP_131155403.1"
                     /transl_table=11
                     /translation="MDIVLGYVDTPHGQRALDEATAQARAHGARLHVVVCDTTSVGEHA
                     SQARDREEGVAAAAERLDELVARLVDDGLDARGEVVRDDRDSAGAALVDYATRAEADLI
                     VVGVRKRSRVGKLLLGSNLQDVILAAPCSVLAAKPADPASGGTVGGEEPSA"
     gene            5289..6280
                     /locus_tag="ER308_RS22470"
                     /old_locus_tag="ER308_13090"
                     /pseudo=""
     CDS             5289..6280
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="ER308_RS22470"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13090"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRFGLQLHGTLELEQFPALASRAEALGLEDVTFHDTLMRRPVWPV
                     LCDIARATEHVRVGPNVTHPFVQHPAVIATNCAHLDEVSGVVRRSALDAGRSTP"
     gene            complement(6299..6679)
                     /locus_tag="ER308_RS13095"
                     /old_locus_tag="ER308_13095"
     CDS             complement(6299..6679)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ER308_RS13095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ER308_13095"
                     /product="hypothetical protein"
                     /protein_id="WP_131155406.1"
                     /transl_table=11
                     /translation="MSDDQQSYRDKGPALRVLFCIGVQQPLFEEPAAKIPELIPQIADA
                     FADLGGRFGITVLGTMDDDELMVGSSPTWPWTAYILADAPSLEAVTGVCNIVRDGEIDE
                     YRLWRYLKIEARVGRQLFFGNE"
     gene            complement(6682..7503)
                     /locus_tag="ER308_RS13100"
                     /old_locus_tag="ER308_13100"
     CDS             complement(6682..7503)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014080.4"
                     /locus_tag="ER308_RS13100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13100"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_131155407.1"
                     /transl_table=11
                     /translation="MDDTITERLVELGLTRNEARAYLSLLRHGRRSAAEVAEAAGIPRP
                     KVYEALNALERRGFVRSGGQRVRAFEAVHSEVALPEWVSRRDQERKLEAEREQRLADEL
                     SATLPSPPEPTPAPAHTELIDVTEGREETAGLYEDLVARTNRTVDVSYAGFGVRPRERW
                     ADAERGALDRGVRVRVLFAPELLDDPARWRPVEEAGGAVRISATFPLKLAIRDGEEALV
                     VLLSEARDGGEGVRTVAIRHPDLVAPLQLLFQQEWRRARAVDTSPDTAQEE"
     misc_feature    7627..7645
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.51"
                     /tool="antismash"
     gene            7773..9020
                     /locus_tag="ER308_RS13105"
                     /old_locus_tag="ER308_13105"
     CDS             7773..9020
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) azdH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191: acyl-CoA dehydrogenase type 2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="ER308_RS13105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13105"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_131155408.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.1e-12, bitscore:
                     45.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="azdH (E-value: 1e-14, bitscore: 52.0,
                     seeds: 3, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 9.4e-15, bitscore:
                     52.6, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.7e-12, bitscore:
                     45.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHCLTDRQREIVELAGRLADTFAERADGPDRENRFPVENYEDMR
                     ETGYLRLTVPEELGGYGADFHELLLAQERLAMGDGATALAVNMHVSPVGQWAAIWRETG
                     NPKLEEFLRAVARDEIVWASITSERGVGNDLTDSTVTAERADGGYRVNGRKIFGTNSAV
                     ATHFSFTARTEDHEHGPRVLLMRTAMGEEAVEIKQTWDTLGMRGTQSNDLVFTDLFVPD
                     EDVVHSMPVGHFDATVLKTAFARGIATFGAVYIGIAGGGIEWARQMVLQRGRETDPVVQ
                     HIFGEVELLQESARAMLYRHAQEVMSGDLFDKYSVQEGLARTSLSKAVCANNGLQIMQR
                     LVDVVGGPAYMKRFPFERMLRDSLAGPIMPYNNVDTQRMLGATSLGVQLKPEIPPDESG
                     HGSRPHTDELVGSGEA"
     misc_feature    9101..9110
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            9169..9930
                     /locus_tag="ER308_RS13110"
                     /old_locus_tag="ER308_13110"
     CDS             9169..9930
                     /NRPS_PKS="Domain: PKS_KR (11-165). E-value: 2.3e-08.
                     Score: 26.1. Matches aSDomain:
                     nrpspksdomains_ER308_RS13110_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="ER308_RS13110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13110"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_131155409.1"
                     /sec_met_domain="adh_short (E-value: 1.7e-29, bitscore:
                     101.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQSQTPDEPRVAVVTGAGQGLGKAIAASLQDSGHRVALVDLDAD
                     AAKAAAHELDPSEQATMAVSADVGDREAFAHALDEVGARWRRVDVLVNNAAASVMRSFW
                     AIEPEEWDHVLGVNLRSVFLGCQLAGPLMREGGWGRIINLSSIAGQQGGAVMGAHYAAS
                     KAGILVLTKIVAQELAGSGVTVNALAPAAIDSPLLQGLGDDAIESLADKIPVGRVGRPE
                     EVGALAAFLASEDAGYITGATLDINGGLHMR"
     aSDomain        9202..9663
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ER308_RS13110_PKS_KR.1"
                     /evalue="2.30E-08"
                     /label="ER308_RS13110_PKS_KR.1"
                     /locus_tag="ER308_RS13110"
                     /protein_end="165"
                     /protein_start="11"
                     /score="26.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGAGQGLGKAIAASLQDSGHRVALVDLDADAAKAAAHELDP
                     SEQATMAVSADVGDREAFAHALDEVGARWRRVDVLVNNAAASVMRSFWAIEPEEWDHVL
                     GVNLRSVFLGCQLAGPLMREGGWGRIINLSSIAGQQGGAVMGAHYAASKA"
     gene            complement(10001..11221)
                     /locus_tag="ER308_RS13115"
                     /old_locus_tag="ER308_13115"
     CDS             complement(10001..11221)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271: 2-isopropylmalate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012885.4"
                     /locus_tag="ER308_RS13115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13115"
                     /product="hypothetical protein"
                     /protein_id="WP_131155410.1"
                     /sec_met_domain="HMGL-like (E-value: 3.2e-55, bitscore:
                     185.5, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITALQPGATNPMVDRAQFYTSPLNAQVLGDAVGRRIGIYDTTLR
                     DGEQSVGVVFDPEDKVRIAHALDRLGVPRIEASFPRVSPRDEEAIRLLVQEDLDAQLWG
                     FGRAVPADIELLAGLGLPATIIEAPVSHTKLAAYGVEPEKMLERIRTAVQAGVESGMRV
                     CFFGVDGSRAHMDHLRASYEAALEGGAEEIAVVDTIGVLAPEAVRHLVGSVRGWVGPDI
                     PIHWHGHNDFGLATAGAVAAVDGGANWIQATINGIGERAGNANIAEIALAFEGLYEHQT
                     GLRLDRLRETSQLVAELAGHGYEPWKSVVGDNLFIRESGAVAMQFHEPEAVEPYAADLV
                     GAERKIVLGKKSGAVSLDIKAEELGLDLDGLDQMALLQEVKRLSEDHRRTITDAEFVEL
                     VKRAQNG"
     misc_feature    complement(11220..11236)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.59"
                     /tool="antismash"
     misc_feature    11222..11238
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.42"
                     /tool="antismash"
     gene            complement(11368..12537)
                     /locus_tag="ER308_RS13120"
                     /old_locus_tag="ER308_13120"
     CDS             complement(11368..12537)
                     /NRPS_PKS="Domain: Aminotran_5 (31-347). E-value: 8.5e-43.
                     Score: 138.6. Matches aSDomain:
                     nrpspksdomains_ER308_RS13120_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012488.4"
                     /locus_tag="ER308_RS13120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13120"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_131155411.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-37, bitscore:
                     127.7, seeds: 34, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.9e-06,
                     bitscore: 24.7, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEFPFERERSSFPILSERSQLTSCSQSALARPVEAAVQRYLTHW
                     REDGMAWVAWMDGVEASRRAFATLIGAEPDEVAVVSSVSHAVAALGTTLDYPSDRPDVV
                     TTEMDFPTVGHSWLPQEQGGARIRFVPWDGGPLRVEALEPHVSRSTRVLSIPHQSYYNG
                     ARADLVEVAALAQEHGTLLLVDAYQSLGTCRVDVRALGIDALVAGAQKYLLGMPGIAFL
                     YLRRELAERLSPRVTGWFGQGNPFAFDIHGGDPAPGARRFDAGTPPMVNGAAAAAGLDL
                     LLTVGIDRIETYLRELTGFGLQQARERGLELATPDQPDRVGPNVAVRVGDANAVAERLA
                     GQDIIVSPRRDVVRIAPHFYTRPTELTDALDAVADIVAAGPPQERAPAP"
     aSDomain        complement(11497..12444)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ER308_RS13120_Aminotran_5.1"
                     /evalue="8.50E-43"
                     /label="ER308_RS13120_Aminotran_5.1"
                     /locus_tag="ER308_RS13120"
                     /protein_end="347"
                     /protein_start="31"
                     /score="138.6"
                     /tool="antismash"
                     /translation="RPVEAAVQRYLTHWREDGMAWVAWMDGVEASRRAFATLIGAEPDE
                     VAVVSSVSHAVAALGTTLDYPSDRPDVVTTEMDFPTVGHSWLPQEQGGARIRFVPWDGG
                     PLRVEALEPHVSRSTRVLSIPHQSYYNGARADLVEVAALAQEHGTLLLVDAYQSLGTCR
                     VDVRALGIDALVAGAQKYLLGMPGIAFLYLRRELAERLSPRVTGWFGQGNPFAFDIHGG
                     DPAPGARRFDAGTPPMVNGAAAAAGLDLLLTVGIDRIETYLRELTGFGLQQARERGLEL
                     ATPDQPDRVGPNVAVRVGDANAVAERLAGQDIIVS"
     misc_feature    complement(12518..12533)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 22.52"
                     /tool="antismash"
     gene            12730..14337
                     /locus_tag="ER308_RS13125"
                     /old_locus_tag="ER308_13125"
     CDS             12730..14337
                     /NRPS_PKS="Domain: AMP-binding (30-424). E-value: 2.4e-77.
                     Score: 252.2. Matches aSDomain:
                     nrpspksdomains_ER308_RS13125_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="ER308_RS13125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13125"
                     /product="AMP-binding protein"
                     /protein_id="WP_131155412.1"
                     /sec_met_domain="AMP-binding (E-value: 2.3e-84, bitscore:
                     281.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPTIAAPGAHPLRALSPRDRTVQELVVRQFRDRADDPLLRGPA
                     DRTYGETHRQVAGVVAWLEARAVGEGERVVVVSENRVELLDLFLGCAFAGAIYVPVNPF
                     LRGEQLRHQLEDAAPTLVLCEQGTHDQVREVLTGFSDPPELLVLGEGTWELDGATPPRP
                     STRELSAGHPPSHPTGVLYTSGTTGPSKGVVCPAGQFFWWGVLTAEYLRLRPSDHLYTT
                     LPLYHINALGAYLQAIGVGASYTFRRGFSASRFIAEAREAEATVTYLLGAMLTILWKQE
                     PSERDREHDLRVALAPATPPDIFERFRERFGFDLVDGFGMTELNLVVSSLPEATRPGRM
                     GWVLDDFEARVVDDEDIEVSDGEPGELVVRPREPHSMCQGYWRRPEATAEAWANLWFHT
                     QDRVVRDDDGALRYLDRMKDAIRRRGENISSFEVEAVVANHPAVAEAACIGVPSELGEE
                     EVMVHVVPQPGEQPSGEDIVRWCADRLAHFAVPRYIAVVGDLPRTPNGKVRKAALREQG
                     AATGTFDREAAGVEIRRG"
     aSDomain        12820..14001
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ER308_RS13125_AMP-binding.1"
                     /evalue="2.40E-77"
                     /label="ER308_RS13125_AMP-binding.1"
                     /locus_tag="ER308_RS13125"
                     /protein_end="424"
                     /protein_start="30"
                     /score="252.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QFRDRADDPLLRGPADRTYGETHRQVAGVVAWLEARAVGEGERVV
                     VVSENRVELLDLFLGCAFAGAIYVPVNPFLRGEQLRHQLEDAAPTLVLCEQGTHDQVRE
                     VLTGFSDPPELLVLGEGTWELDGATPPRPSTRELSAGHPPSHPTGVLYTSGTTGPSKGV
                     VCPAGQFFWWGVLTAEYLRLRPSDHLYTTLPLYHINALGAYLQAIGVGASYTFRRGFSA
                     SRFIAEAREAEATVTYLLGAMLTILWKQEPSERDREHDLRVALAPATPPDIFERFRERF
                     GFDLVDGFGMTELNLVVSSLPEATRPGRMGWVLDDFEARVVDDEDIEVSDGEPGELVVR
                     PREPHSMCQGYWRRPEATAEAWANLWFHTQDRVVRDDDGALRYLDRMKDAIRRR"
     CDS_motif       12994..13032
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ER308_RS13125_0001"
                     /evalue="6.30E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ER308_RS13125"
                     /protein_end="101"
                     /protein_start="88"
                     /score="10.2"
                     /tool="antismash"
                     /translation="LGCAFAGAIYVPV"
     CDS_motif       13267..13314
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ER308_RS13125_0002"
                     /evalue="1.70E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="ER308_RS13125"
                     /protein_end="195"
                     /protein_start="179"
                     /score="17.5"
                     /tool="antismash"
                     /translation="VLYTSGTTGPSKGVVC"
     CDS_motif       13813..13902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ER308_RS13125_0003"
                     /evalue="8.40E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="ER308_RS13125"
                     /protein_end="391"
                     /protein_start="361"
                     /score="15.0"
                     /tool="antismash"
                     /translation="GEPGELVVRPREPHSMCQGYWRRPEATAEA"
     gene            14357..15523
                     /locus_tag="ER308_RS13130"
                     /old_locus_tag="ER308_13130"
     CDS             14357..15523
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="ER308_RS13130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="ER308_13130"
                     /product="thiolase family protein"
                     /protein_id="WP_131155413.1"
                     /transl_table=11
                     /translation="MRVRRFDRAGITGLAELPVRVRGETRQTIELLGEAARGAVGRAGV
                     AWEDVDGLALGGFTLGPDGAVHVATRLGLQPRWLAPQDPGGASGVAAVLAAARAVEAGD
                     ADVVLCVAGDALDGPALVDLGKRFSADTRDWLTPIGAEPANVTFALLADHYLRAHGLTR
                     ADMGVVSVLQRRHGAMNPNAVFGDPIALFDYLGAPPVATPLHLLDCVRPGSGASAVVVQ
                     KVSRRRSSRPRGVRVLAGAEAHGAAPEWPPRELGWRGFVDDLFDAAGMIHDDLDVLELY
                     DDYPFMVLWQLEELGFCAPGGASAWLRNHDLGVAAPPALNTGGGMLACGQAGAAGGYVP
                     VVEAARQLLGTAGTRQVPGARRGLVSGLGMVRYGAPLSVSAMMLETIP"
     gene            15537..15932
                     /locus_tag="ER308_RS13135"
                     /old_locus_tag="ER308_13135"
     CDS             15537..15932
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013920.4"
                     /locus_tag="ER308_RS13135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13135"
                     /product="OB-fold domain-containing protein"
                     /protein_id="WP_131155414.1"
                     /transl_table=11
                     /translation="MSRRSEEIASLDTLRERWLTAAREGPPRFPACAGCQAWSWPPTVV
                     CPVCGEGRWRLVSVPGTGLVRAATTVHRGVAPEFADEAPYRVGAVALDDGPLFLTRLDV
                     GVHQGSRVRLRWRDRPGDGWLWASAGA"
     misc_feature    15570..15583
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.58"
                     /tool="antismash"
     misc_feature    complement(16041..16056)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.15"
                     /tool="antismash"
     misc_feature    complement(16045..16054)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.81"
                     /tool="antismash"
     misc_feature    16146..16161
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.6"
                     /tool="antismash"
     gene            16190..17380
                     /gene="dctP"
                     /locus_tag="ER308_RS13140"
                     /old_locus_tag="ER308_13140"
     CDS             16190..17380
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="dctP"
                     /inference="COORDINATES: protein motif:HMM:NF015445.4"
                     /locus_tag="ER308_RS13140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13140"
                     /product="TRAP transporter substrate-binding protein DctP"
                     /protein_id="WP_131155415.1"
                     /transl_table=11
                     /translation="MHTTRTPAHPRIPRRPRAALLVVGLLALALALAACAEDEPDDAVD
                     EPDDDVEEPEDEPDDDDDDAADDPADGDADEPDEDADDPEDEADEDGDEPEEVTLEFVT
                     AWEDDSDEVQGFWQFAERLEEEAPWIELEYRGGPETFPNDQQGEAVRDGAVDMSVVAAT
                     YYTQNMPFAHAMKLTPFLPEEEREHGIYDLYREQHREHLNAHYLGKTKANTPFFLYSNE
                     PIESADLSGLRVRVSPVYEPLVQELDGSAVSMAPDEVYTALERGAVDAFGWPATGVTDR
                     GWEEVTEYELRPGFYELDVGVIVNIDVWEGLDERTREAMTDAMEETEREIPDFYEESLE
                     EEVAEREAAGMEIIELPDDEAEAFLEAADRAGWEDAIEQAPEAEEFRELIEEIEGE"
     gene            17422..17964
                     /locus_tag="ER308_RS13145"
                     /old_locus_tag="ER308_13145"
     CDS             17422..17964
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0031317 - tripartite ATP-independent
                     periplasmic transporter complex [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0015740 - C4-dicarboxylate transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016200.4"
                     /locus_tag="ER308_RS13145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13145"
                     /product="TRAP transporter small permease"
                     /protein_id="WP_131155416.1"
                     /transl_table=11
                     /translation="MGLRSPWGPLETVERALTAVGAIILAWLAVSITVAVLSRHFAGEP
                     IGWTFEIAEYSLVVITFAAIALVGREDGHVRMELLGEVLPQRVQRVLTLIAETISLLVL
                     AAAFVAAVAITAENLADGTRVSGILRIPRWLVLAIMPVGLGLLAIEHGKRLARAVRPGS
                     TGWAGSTGSAADPDTQG"
     gene            17967..19358
                     /locus_tag="ER308_RS13150"
                     /old_locus_tag="ER308_13150"
     CDS             17967..19358
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018513.4"
                     /locus_tag="ER308_RS13150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13150"
                     /product="TRAP transporter large permease subunit"
                     /protein_id="WP_165492069.1"
                     /transl_table=11
                     /translation="MEWPLLLAAFLGALIILLLLRVPVAIALLGVNLVGVVWLFGWDAG
                     TRQLVLSVQGGLSTFVLSPVPLFILMGEVLMASGLASRALSAVERSMGRLPGRLGLVTT
                     AGGTLFGILSGSTLANTALLGKAFLPQMLREGYGVRYGMGSILASGGLAMIIPPSALAV
                     VWGATAGVAIGPLLIGGLLPGLLMAVNYAIVLIGWSWLAGRRSRRSAPVVATEGATEGA
                     TVEGRVERSGDQEATRDHETPDAPPSLLVDVAPLALLIALVLGLIFFGVATPTESAAAG
                     AVGSVVLAAAYRRLGRATMWSALVGSAKVSAVIFFILAGSDVYSRIMSFSGATSGVIGA
                     LLDVDAGPIVTLILMQVAVVLLGLFLEQISIMLVTLPFFMPVVEAMGWHPVWFGIIMLI
                     NLQIALTTPPFGMSLFVMKGVAPRGVKLTDVYLAAVPFVLADVVAIALLILVPGIALWL
                     PELML"
     gene            19407..20174
                     /locus_tag="ER308_RS13155"
                     /old_locus_tag="ER308_13155"
     CDS             19407..20174
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016115.4"
                     /locus_tag="ER308_RS13155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13155"
                     /product="cyclase family protein"
                     /protein_id="WP_205745604.1"
                     /transl_table=11
                     /translation="MSTEAIDLPGLGALTVVDLAQPLTETTPTIQLPEPFANTPPFRLH
                     EISRYDERGPVSYWNWFECGEHVGTHLDAPNHWVSGQGGRPVDEIPLRQLVAPAVVIDR
                     TDEAAADPDYLLGLEDVRAFEAEHGPLPEGGWLLYRTGWSRYAQDQEQFLNADESGAHT
                     PGIQAECARWLAEESGIIGIGVETVGTDAGQAFELDPVFPVHHYMHGAGKLGLTQLANL
                     DRLPATGTTLAAAPLKIEGGSGSPTRVYGLLPR"
     gene            complement(20244..21497)
                     /locus_tag="ER308_RS13160"
                     /old_locus_tag="ER308_13160"
     CDS             complement(20244..21497)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="ER308_RS13160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13160"
                     /product="cytochrome P450"
                     /protein_id="WP_131155419.1"
                     /sec_met_domain="p450 (E-value: 1.2e-26, bitscore: 91.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARRSALGEPHPLRFDPLSPEQLENPYGIYEQLRDEAPVFYAEPF
                     DLWVISRYEDVLAAARDHETFSSRHAVRSSMATPPPEVEAVLAEGYPQLGTLTDSDEPY
                     HRRLRGLVNQAFTPKRVAMLEPRLDQLAEELIAGFASDGEAELIDRFAWPYPLAGIADM
                     LGLNRADLEDLHLWSYHWLKLIQATDPVEDQVAYAESFVALQRLVMRELEARQEQPTED
                     LMSALLEARLEGERPLSLEEALWVPLNLIIAGHVTVTRAIGNSLLLLFQNPRLRETLEA
                     DLEQRMPAAVEEFLRLESPAQGLFRTTTRQVEVDGVTLPAGARVMLHYGSANRDPRRYE
                     DPDEADLERAGVRKHLAFGTGIHVCIGAPLARLELRIALTKLLRRLPGPRLAGEPERDT
                     IFFARGLSRLPVAWEPDG"
     gene            complement(21562..22371)
                     /locus_tag="ER308_RS13165"
                     /old_locus_tag="ER308_13165"
     CDS             complement(21562..22371)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1044: ABC
                     transporter, permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.4"
                     /locus_tag="ER308_RS13165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13165"
                     /product="ABC transporter permease"
                     /protein_id="WP_205745605.1"
                     /transl_table=11
                     /translation="MSERTPVLTTGAAGGRARERLGAGMAPVALLVGLILLWELLVRVL
                     GVREFTLPAPTSIAATLLEDAESLTGHFLTTLGQTLLGYAAAIVLGVPLAFLIAYSRIA
                     ERTLYPLLVTAQSVPKVAIAPILVMWLGFGILPKVILIILICIFPIVVSCAAGLKSTDE
                     EFIELSRSLKASEWQIFRKVRFPSALPQTFVGLKVAMTLAVIGAVVGEFSGADAGLGFV
                     VIIAGGTANTSLAFASILLLSAMSVALFYGLVALERLLVPWASTTGD"
     gene            complement(22364..23170)
                     /locus_tag="ER308_RS13170"
                     /old_locus_tag="ER308_13170"
     CDS             complement(22364..23170)
                     /EC_number="7.6.2.14"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="ER308_RS13170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13170"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_205745606.1"
                     /transl_table=11
                     /translation="MEHSTALLRLQGVSKTFGPGTAGAVDALHGIDLDVGRHEFVSLVG
                     RSGCGKSTLLRLIAGLIPPTAGTVSVADEVVTGPREDVGLMFQRPALFPWRTVLENVLF
                     PVEILGGTSDAHLDRARALLDMVGLGGFEHRRPKALSGGMQQRAALCRALVHDPDILLM
                     DEPFAALDALTREELSQELQRIWLETTKTIVLVTHSITEAVTLSDRVVTLTPRPGRIGS
                     VQPIDASRPRSENSPELADHAERVRRELIGDPVPPDEQSTSRPDRE"
     gene            complement(23225..24217)
                     /locus_tag="ER308_RS13175"
                     /old_locus_tag="ER308_13175"
     CDS             complement(23225..24217)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020650.4"
                     /locus_tag="ER308_RS13175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="ER308_13175"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_165492070.1"
                     /transl_table=11
                     /translation="MSGVVVALGVGACATEGAEDTPADDAEADTVTEISYATSFGTFGR
                     DAYVYVADAHGHFEDAGLEVDIVPGGGSVDNAQLIAQGQLEFAPIDFASTAIVRANEEV
                     PVKIVSFVHQDALTAILAPEGAGIEEPGELEGRTLAGAPAGADTLLFGPYADAAGFDGD
                     AVDFRPTEPPQLPQILAGGEADAVQQFVVGIPLFEQATDDDIVAFPYADHIPDLPGLGI
                     AASDDLIEEDPELITRFVTALNHGLQEALDDPEEAATVMEERVDEVDVDIAARELEIMR
                     DYVVTDYTEEHGLGHIDESRLESLLDTAEEAFELEQPVSLDEVYEPLAP"
ORIGIN
        1 gcatcccggt cctggaggcg ttcggcgcga gcgggaccgg catgccgatg ccggaggtcc
       61 cggaggcggt cgagaccggg gtcatcgagg gggtgctcac ctcccgcgag accctggagg
      121 acttcgcgct cgccgagaac ctcggctaca cggtcgatca cccgacggtg gtgaactcct
      181 tcgctgcggt catggacctc gaccagtacg agggcctgcc cgccgacgtc caggaggcca
      241 tcgacgggct cggccccgag atggcggagt ggaccggcaa ctaccacgac accgacaacg
      301 tcgagggcgc gctcgagtgg gccgatcagg agcacggcca cgagatcgtc gagctcgacg
      361 aggacgaggc cgagcgctgg gacgagctca tggagccgat caccgaagcg tggctcgacg
      421 aggccgagga cgcggggctc ccgggcgacg agttccacga gcgcatgctc gagctccgcg
      481 acgagcacgc cgaggagcac ggatagcccg ggcgggttgc gggctgatcc gcccgcagcc
      541 cgcccgccac cgtgggacga tcgacggcca cgacgtcagg aggggcgagt ggggacacca
      601 ccgcggacgc cccctcgctc cggtgctgag cgagcggaac cggcgggatc cggacgcgac
      661 cgttgagcgt ggtcgcggtg ctcggcggcg gcaacggggc gcatgccgcc gtggtcgacc
      721 tgcaactcaa gggctatcgc gtcgcgtggt ggcgtcgcga cgcgggggcc ttcccccccg
      781 acgggtgcct ccgctacacg gggatcctcg gcgagggcga gatcaccgtc gaacggtgca
      841 ccgacgtcct cgccgaggcc gtcgaggacg ccgatctcgt cgtcgcgccg ctgccggccg
      901 acgcgcaacc gccgctgctc gaccggctcg cgcccgccct ccgggacggg caggcggtcg
      961 ccttcacgcc gggcacgttc ggctcctggt tgggagcgca gcggcggccc ggggtcacgt
     1021 tcctcgagac cgggacgctg ccgtacctcg cgcgcgtgac cgcccccggc gaggtgtcga
     1081 tcccggtcgt cgcgacccgg ctgccgaccg gttcgatccc cggggagggg ccggccgcgg
     1141 acgcggccca cgaggcgttc gcggccgcct acccgtcggc cgttcgcgtc agcgacgggt
     1201 gggacgcggc gctgtgcaac tgggggccgg tgctgcaccc gccgctgatc gtgcagaatc
     1261 tcggcgcgat cgagtcgctc ggggacgcgt tcgacatcca tgcggccggg acgtccgagg
     1321 gcgtggtccg cacgatcctc gcggtcgacg aggagcgcat cgcgctgcgg cgcaccctga
     1381 acctccccgg tgagcactgg cccatccgca cgcactacga cgaatcgccc caggggatgt
     1441 acggcagcga cgcgaagcgg cgtctcgtcg agagcggcct gtggcgggaa cggctgcacc
     1501 cacgtcaccg ctacgtgacc gaggacctgc tctgcgggct cgtcctgacc gcctcgtggg
     1561 ggcgcgccgc gggccagccg atgcctgtca gcgaggccct gctgacgctc gcggccccgt
     1621 ccctcggggt cgatccctgg acggaagggc ggagcgccgc ctcgatcggc gccgaggacc
     1681 tcgaggtgct ccgtgccgcg gcacgccatg gaggggggcg atgagcagcg aggcggcggc
     1741 acggggagga ctcgacgagc gggtcgaccg ggtgagccgc cgcgcgaacg gtgcgctggc
     1801 gacgctggcg gccatcgcgg tgctgtcgat catgctgctc acggtcgtga acatggtcct
     1861 gcggttcgcg ggcgcgccga tcgcgggctc gttcgagctc gtggggtggc tggccgccct
     1921 cacgaacggt ctcgcggtcg gctacacgca gacccggcgc ggccacgtcg acatcgacgt
     1981 gctgacccgg ttgatgcccc tccgcatcca ggccgtcctg cgcgccgtga tgaccggggt
     2041 ggccacgggg ttcttcgtca tcgtcacctg gcagctcgtc gagcacggcc tgcacctgcg
     2101 cgacgtgggg agcctctcgg acgtgctgcg cgtccccttc tatccgttca cgttcgccgt
     2161 ggctgtcggg ttcgccgggt tcgtcctcgc gctgttcgct gatctccttc ggcacgggcg
     2221 ggaggcgatg gttccgcgtc gtgagggcga tcggacgggg tggacgggga cggccacgga
     2281 catggccgac gacgacgggt cggaaggacg ggaatgagcg atctcgcgat cgcgggcatc
     2341 ggcgtcgtcg cgatgctcgc gttgatgctg ctgcgcatgc ccgtcgcgtt cgcgatgatg
     2401 atcgtcgggt tcgtgggcgc catggtcgtg ctcacaccgg atgcggcgct ccagttgatc
     2461 agcgccgacg tgtggaacca gctctcggcg ttcagcctca gcgtcatccc gatgttcgta
     2521 ctcatggggc aggtcgccta ccgctcgggc atcacccagc ggctgtacga gaccgcctac
     2581 aactggctcg gccacctgcc cggcggggtc gccgccacga cgatcctcgc gagcatgggc
     2641 ttcgcgatgg tctccggctc gaacaccgcc accacggcga cgatgggcac ggtggcgctg
     2701 ccggagatgc gtcgctacgg ctacgcgcgc tccctcgcga gcagcagcgt cgcgatgggc
     2761 gggaccctcg gcgtggtcat ccccccgagc gtggtcctga tcgtgatcgc catccaggcc
     2821 gagctgtcca tcggacggct gttcgtcgcc gcgatcgccc ccgggatcat gctcacgatc
     2881 atgctgctcc tgaccgtcgt cgtcctgtgc cgcctgcgcc ccgagctggg accgccgagc
     2941 gagaaggcct cctggggaca gcggctcggc tcgctcggtg gtgtcatcga gacgctcgtg
     3001 ctgttcgcgc tcgtgatcgg gggcttgtac ctgggctggt ttacccccac cgagtcgggc
     3061 gccatcggcg ccttcggggc gttcgtgatc gggttcgcgc gccggaacct gaactgggag
     3121 cagatcaagc tggccacgct cgagacgctg cggatctcgg cgatggtgat cctcctgctc
     3181 gccggcgcgg tcgtgatcag ccgcttcctg accgtgacgc gcctgccgtt cgagttggcc
     3241 gagtgggcgg cggacgtcgc cgtcgatccc ctgtggatgc tgctgatggt gttgctgatc
     3301 tacctgatcg gcggcctgat catggatgcg ctgggcttcc tcgtcgcgac gatcccgatc
     3361 ttcttcccgc tcgcgctcgc gctcgacttc aacccgatct ggttcaccct gctcatcacg
     3421 ctcgtgacga gcctgggggc ggtcaccccg ccggtcgggg tcaacgtgta catcgtgagc
     3481 tccctggacc ccgacctggg cgtggtggag gtcttccggg gcgtcctgcc gttcatgctc
     3541 tcctacgtgc tcgtgatcgc gttgctgatc gccttcccgg gcatcgcgct cttcgcgctc
     3601 tagcacccat cccccgacgt cgaggaggag acagcgatga tccagcccta ctccgcggtc
     3661 ggcctgatcc ccacggtgcg ggggatcagg acccgcgacg acatccagcg caacctcgat
     3721 cacctcgccg agctcgtcac cgcggcctcg tggctgtcga gcatggacct gccggtccgc
     3781 ctcgtcatcg tgccggaggg cgccctgcag ggcttcaacg acgaggtcct cgatctgcac
     3841 cacgagacct tcgcccggga gtgcgcgatc gacctgccgg gcaaggagac cgagttcctc
     3901 ggcgacctcg cgcgcaagtg gggcgtgtac ctcatggccc aggcgaaggt ccgccacccg
     3961 gagttccccg gccgcttctt caacgccggg ttcgtcctcg acccgcaggg cgagttgatc
     4021 ctcatccact acaaggtggt accgctgctg ccggtggagc actcggtgac cccgcacaac
     4081 gtgtgggacc ggtgggtcga gctctacggc gagacgctcg acgccttcta cccggttgtc
     4141 gacaccgaca tcggccgcct cggcgtcatg atggccaacg agggctccta ccccgagaac
     4201 gcgcgcggcc tcgcgatgaa cggggccgag gtggtctacc gcgcgtcgta cccgcacccg
     4261 cacaccggca acgagctgtt cgaggtccag aaccgggcgc gggcgctcga caacaacttc
     4321 tacgtcctcg cgccgaacat ggggacctac tacctgcacg ccgaggacga gctgccgatc
     4381 gacacgttcg gcgggcggtc gatgatgtgc gactacaagg gccgggtcgt gggccagcag
     4441 gactacggcg cgggttcgac ctacatcgcc ggacagatcg acgtcgaggc gctccgggac
     4501 ttccgcacgc gggcccagat gaacaactgg atgaaggatc tcaccaccga gcagtaccgg
     4561 ctgatctacg accagcccgt gtatccgaag aacctctacc tcgatcgtga gccgtacgac
     4621 cacgcggatt acaaggcaca ggtgaccgac cggcagatcg agtacctcgt cgagcgcgac
     4681 atctaccgct ggcccgaggg tcggtgagcg tggcgcgggc gtcggcgggt ccgtggtgga
     4741 tccgcacggt gcgatcggag atcccatgga catcgtgctc ggctacgtcg acaccccaca
     4801 cggtcagcgg gcgctcgacg aggcgacggc gcaggcccgc gcgcacggcg cccggctgca
     4861 cgtggtcgtg tgcgacacga cgagcgtcgg cgagcacgcc tcgcaggccc gggatcggga
     4921 ggagggggtc gcggcggcgg ccgagcggct cgacgagctc gtcgcaaggc tcgtcgacga
     4981 cggtctcgac gctcgcggcg aggtggtgcg cgacgaccgc gacagcgccg gtgcagcgct
     5041 cgtggactac gcgacgcgcg ccgaggccga tctgatcgtg gtcggggtgc gcaagcgctc
     5101 ccgggtcggc aagctgctgc tcggcagcaa cctgcaggac gtcatcctcg cggcgccctg
     5161 ctcggtgctg gcggccaagc ccgccgaccc cgcgtcgggc ggcaccgtag gtggtgagga
     5221 gccgtcggcg tgacccggtt cactccgcac caccgcacgg ttcgcggccg tctgcacggg
     5281 cgggcctgat gcggttcggg ctgcagctgc acggcaccct cgagctcgag cagttcccgg
     5341 cgctagcgag ccgagcggag gcgctcgggc tcgaggacgt caccttccac gacaccttga
     5401 tgcgccgacc cgtgtggccc gtgctctgcg acatcgcgcg ggccaccgag cacgtgcgcg
     5461 tcgggccgaa cgtcacgcac ccgttcgtgc agcacccggc cgtgatcgcg acgaactgcg
     5521 cgcacctcga cgaggtgtcg ggggtcgtgc gacgctcggc cttggacgcg ggtcgctcta
     5581 ctccctgatc ggcgagcgtc accgcggctc gctgcagggg ctcaccgagg ccgtgcacgt
     5641 gtgccggatg ctgctcgagg gcgacgacac cccgtggcag ggggaggtgt tcgcgctcgg
     5701 accgggtcac gggttgaagt tcgggacgcg ccggcgcgtg ccgatctcac tcggggtctt
     5761 cggaccgaag ggctgccgcc gcgccggcgc gatcgccgac ggcgtgcgag ccgcggcgca
     5821 gtgggacccc gcgtacatgt cccgggcgcg cgagtggatc gccgaggggg cgcgggaggc
     5881 cggtcgtgac ccctcggcgg tggaggtcgt gctcgagaac tggacgtgcc tcgacgccga
     5941 ccgtgagcgc gcgcgagccc gggcgcggga ggtgctcgcc acgttcctgc cggagttggg
     6001 tccgctgctg tcgttctacg agatccccga cgtcgaggtg caggccgccc gcgacgccac
     6061 ggttcacggg gaccgcgacg cgctcgcgac gatcagcgag cagaccatcg atcggttcat
     6121 ggccgcgggc gacgccgacg acctgcgtcg cgggctcggt cggctcgagg cggccggctt
     6181 cgacgcggtg tcgttctccg ggatcctcgg cccgcgaccc gaagacgcct tggagatcct
     6241 cggtgccgag atcgcacgtc gggcggaagc gacccgctga ggctcgagcg gggccctctc
     6301 actcgttgcc gaagaacagc tgacgcccga cgcgggcctc gatcttcagg tagcgccaca
     6361 ggcggtactc gtcgatctcc ccgtcgcgga cgatgttgca gacgccggtg acggcctcca
     6421 gcgacggggc gtcggccagg atgtacgccg tccagggcca cgtgggcgac gagccgacca
     6481 tgagctcgtc gtcgtccatc gtgccgagga ccgtgatccc gaagcgccca ccgaggtcgg
     6541 cgaaggcgtc ggcgatctgg gggatcagct cggggatctt ggcggccggc tcctcgaaca
     6601 gcggctgctg cacgccgatg cagaagagca cccgcagcgc tgggcccttg tcgcggtagc
     6661 tctgctggtc gtcggacatc gttactcctc ctgtgccgtg tcgggggacg tgtcgacggc
     6721 gcgggcgcgc cgccactcct gctggaacaa caactgcaac ggggccacga gatccgggtg
     6781 gcggatcgcg accgtgcgaa cgccctcacc accgtcccgc gcctcgctga gcagcacgac
     6841 gagtgcctcc tcgccgtcgc ggatcgcgag cttcaggggg aacgtcgccg agatccgcac
     6901 cgcgcctccc gcctcctcga cgggtctcca gcgcgcggga tcgtcgagga gctcaggggc
     6961 gaagaggaca cgcacgcgca cgccgcggtc gagggcgccg cgctcggcgt cggcccaccg
     7021 ctcccggggg cgtacgccga agcccgcgta cgagacgtcg acggtacggt tcgtgcgcgc
     7081 cacgaggtcc tcgtacaggc cggcggtctc ctcccggccc tccgtgacat cgatgagttc
     7141 ggtgtgcgcg ggcgccgggg tgggctcggg tgggctcggc agggtcgcgg agagctcgtc
     7201 ggccaggcgc tgctctcgct cggcttcgag cttgcgctcc tggtcgcgtc ggctcaccca
     7261 ctcgggcagg gccacctcgc tgtgcacggc ctcgaacgcc cggacccgct gacccccgga
     7321 ccgcacgaac ccgcgccgct cgagcgcgtt cagcgcctcg tacaccttcg ggcgggggat
     7381 tccggccgcc tcggcgacct cggcggcgga tcggcggccg tggcgcagca gcgagaggta
     7441 ggcccgggcc tcgttgcgtg tgaggccgag ttcgacgagc cgctccgtga tcgtgtcgtc
     7501 catggccgcc tcgtgtcgcc ggcgccgctc gggcggtgga ccggtgccgt actcgggacg
     7561 ggtggcgcgg ccccgctcgc cccttgacag cgcgggtgcg aggtcggcta tggtgtcact
     7621 aaccctaggt agtatcaagt atcaaccctc gtgcacccga actcgtgcac ccgagtcgtc
     7681 gttcgtgatc cgcccaacgc tccggctcgg tgtcccgggg gtcggcgcgc tcggtggtga
     7741 ccgtgcccac gacggcgagg aaggtggtag caatgcagca ctgcctcacg gatcggcaac
     7801 gggagatcgt cgagctggcg ggccggctcg ccgacacgtt cgcggagcgt gccgacggtc
     7861 ccgaccggga gaaccgcttc ccggtggaga actacgagga catgcgcgag accgggtacc
     7921 tgcgcctcac ggtgcccgag gagctcggtg ggtacggcgc cgacttccac gagctcctgc
     7981 tcgcgcaaga gcgtctcgcg atgggcgacg gcgccacggc gctcgcggtg aacatgcacg
     8041 tgtccccggt ggggcagtgg gccgcgattt ggcgcgagac gggcaacccc aaactcgagg
     8101 agttcctgcg ggcggtggcc cgcgatgaga tcgtctgggc gtcgatcacc tccgagcggg
     8161 gcgtcggcaa cgacctcacg gactcgaccg tcaccgccga gcgcgcggac gggggctacc
     8221 gcgtgaacgg ccggaagatc ttcgggacca actcggcggt cgcgacgcac ttctcgttca
     8281 cggcgcgcac cgaggaccac gagcacgggc cgcgggtgct gctgatgcgc acggcgatgg
     8341 gcgaggaggc cgtcgagatc aagcagacct gggacaccct cggcatgcgc gggacccaga
     8401 gcaacgacct cgtgttcacg gatctgttcg tgccggacga ggacgtcgtg cactcgatgc
     8461 ccgtcgggca cttcgacgcg acggtcctga agacggcgtt cgcccgcggg atcgcgacgt
     8521 tcggggccgt ctacatcggc atcgccggcg gcgggatcga gtgggcccgg cagatggtcc
     8581 tccagcgcgg ccgagagacc gacccggtcg tccagcacat cttcggggag gtggagctgt
     8641 tgcaggagtc ggcgcgggcg atgctctacc ggcacgcgca ggaggtgatg tccggggacc
     8701 tgttcgacaa gtactccgtg caggagggcc tcgcccgcac ctcgctgtcg aaggccgtgt
     8761 gcgcgaacaa cgggctgcag atcatgcagc gtctcgtcga cgtcgtcggg ggcccggcct
     8821 acatgaagcg gttcccgttc gagcgcatgc tccgcgacag cctggccggc ccgatcatgc
     8881 cgtacaacaa cgtcgacacc cagcgcatgc tcggcgcgac gagcctcggc gtgcaattga
     8941 agccggagat cccgcccgac gagtccggcc acggcagccg gccgcacacc gacgagctgg
     9001 tgggcagcgg cgaggcctag accccgggcg agacgagacc cccgggggcg agacccccgg
     9061 aaggcagaga cccccggggg ttcgttcgcg ccgggtcgcc gaaggcggcc ttccgcgtct
     9121 gctcgccaac cgtcatgatc tggggggagc acgagccaag gaggggtcat gacccagagc
     9181 cagacacccg acgagccccg cgtcgccgtc gtgaccggcg ccgggcaggg cctcggcaag
     9241 gcgatcgcgg cctccttgca ggactccgga caccgggtcg cgctcgtgga tctcgatgcc
     9301 gacgccgcga aggccgccgc gcacgagctc gatccgtccg agcaggcgac catggccgtg
     9361 tccgccgacg tgggcgatcg ggaggcgttc gcgcacgcgc tggacgaggt cggcgcgcgc
     9421 tggcggcgcg tggacgtgct cgtcaacaac gcggccgcct cggtgatgcg gagtttctgg
     9481 gcgatcgagc ccgaggagtg ggatcacgtg ctcggggtga acctgcgcag cgtgttcctc
     9541 ggctgtcagc tcgccggtcc gctcatgcgc gaggggggat ggggccgcat catcaacctc
     9601 tcctcgatcg ccggccagca gggcggcgcg gtgatgggtg cgcactacgc ggcgtcgaag
     9661 gccgggatcc tcgtgctgac caagatcgtg gcgcaggagc tcgccggatc cggcgtgacc
     9721 gtcaacgcgc tcgcgccggc ggcgatcgac agtcccctcc tgcaagggct cggtgacgac
     9781 gcgatcgagt cactggccga caagatcccg gtcgggcggg tcgggcgccc cgaggaggtc
     9841 ggcgcgctcg cggccttcct cgcctcggag gacgccggct acatcaccgg cgcgacgctg
     9901 gacatcaacg gcgggttgca catgcgctga ccgccgggac gcgttgcggt ggctccgcga
     9961 cgcggtgccc gctcgtcgtg acgtcgctcg gagcgggtgg ctacccgttc tgcgcgcgct
    10021 tcacgagctc gacgaactcg gcgtcggtga tcgtgcggcg gtgatcctcg ctcaagcgct
    10081 tgacctcctg caggagcgcc atctggtcga gtccgtcgag gtcgagtccg agctcctcgg
    10141 ccttgatgtc gaggctgacc gcgccgctct tcttgccgag cacgatcttg cgctcggctc
    10201 cgacgaggtc ggcggcgtag ggctcgacgg cctcgggctc gtggaactgc atcgccaccg
    10261 cgccgctctc gcggatgaac aggttgtcgc ccaccaccga cttccacggc tcgtagccgt
    10321 ggccggcgag ctccgccacg agctgggacg tctcgcgcag gcgatcgagg cgcaggcccg
    10381 tctggtgctc gtacaggccc tcgaacgcga gcgcgatctc ggcgatgttc gcgttgccgg
    10441 cgcgctcgcc gatcccgttg atcgtcgcct ggatccagtt ggccccgccg tcgacggcgg
    10501 cgaccgctcc cgccgtggcc agcccgaagt cgttgtgccc gtgccagtgg atcgggatgt
    10561 cgggacccac ccatccccgg accgagccga cgaggtggcg gaccgcctcg ggcgccagca
    10621 cgccgatggt gtcgaccacc gcgatctcct cggccccacc ctcgagcgcg gcctcgtagg
    10681 acgcgcggag gtggtccata tgcgcgcgcg acccgtcgac gccgaagaag cacacgcgca
    10741 tgccgctctc gaccccggcc tgcaccgccg tacggatccg ctcgagcatc ttctcgggct
    10801 cgaccccgta cgcggcgagc ttggtgtggc tgaccggcgc ctcgatgatg gtggcgggca
    10861 gcccgagccc cgcgagcaac tcgatgtcgg cggggaccgc gcgcccgaag ccccacagct
    10921 gcgcgtcgag gtcctcctgg accagcaggc ggatcgcctc ctcgtcgcgc ggtgacacac
    10981 gcgggaagct cgcctcgatc cgcggcaccc cgagccggtc gagcgcgtgg gcgatgcgca
    11041 ccttgtcctc ggggtcgaac accacgccga cgctctgctc tccgtcccgc agcgtcgtgt
    11101 cgtagatccc gatcctccgg ccgacggcat cgccgagcac ctgggcgttg agcgggctcg
    11161 tgtagaactg cgcgcggtcc accatggggt tcgtcgctcc aggctggagg gctgtgatca
    11221 ttcgatatta gatcacatcg ccaggtgatt cgaaagcctc gaaccggccc gtgtggtttc
    11281 ccagcctcga gctcggcgga gggtcgccgc ggtgggcgtc gagcggtttc gtgccggcgc
    11341 agtggtcggt gtcgctcgca cgggcgctca gggcgcgggg gcacgctcct ggggagggcc
    11401 ggcggcaacg atgtcggcca ccgcgtccag cgcgtcggtc agttcggtgg ggcgtgtgta
    11461 gaagtggggc gcgatccgca ccacatcgcg gcgcggggag acgatgatgt cctgtccagc
    11521 cagccgctcg gcgacggcgt tggcatcgcc cacgcgtacc gcgacgttcg ggcccacccg
    11581 atccggctgg tccggtgtcg cgagctcgag cccacgttcc cgggcctgct ggagaccgaa
    11641 ccccgtgagc tcgcgtaggt aggtctcgat cctgtcgatg ccgaccgtga ggagcaggtc
    11701 gagccccgcg gcggctgccg cgccgttgac catcggtggc gtgccggcgt cgaagcgccg
    11761 ggcgccgggc gccgggtcgc cgccgtggat gtcgaacgcg aaggggttgc cctgaccgaa
    11821 ccatccggtc acccggggcg acagacgctc ggcgagttcg cggcgcaggt agaggaaggc
    11881 gatgccaggc atcccgagca ggtacttctg ggccccggcc accagcgcat cgattccgag
    11941 cgcacggacg tcgacgcggc acgtgccgag tgactggtag gcgtccacga gcaggagggt
    12001 cccgtgctcc tgcgccagcg ccgccacctc taccaggtcg gcccgcgcgc cgttgtagta
    12061 gctctggtgc gggatcgaga gcacccgcgt gctcctcgac acgtgcggct ccagggcctc
    12121 cacgcgcaac ggacccccgt cccaggggac gaaccggatc cgagcacctc cctgttcctg
    12181 ggggagccac gagtgcccca ccgtggggaa atccatctcg gtcgtgacga cgtccgggcg
    12241 gtccgagggg tagtccagcg tggtgcccag tgcggcgacc gcgtggctga ccgaggaaac
    12301 caccgcgacc tcgtcgggtt cggcgccgat tagcgtggcg aaggccctcc gcgacgcctc
    12361 gaccccgtcc atccaggcca cccacgccat gccgtcctcg cgccagtgcg tgaggtaccg
    12421 ctgaacggct gcctcgacgg gtctggccag cgcgctttgc gaacagctcg tgagctggct
    12481 gcgttcgctc aagatgggaa agctcgaacg ctcccgctcg aacgggaact cgatcatgac
    12541 aggcccccaa ccgcttcgct ggtcgacacc gaatcgttgc tgccacgtcg ccacctctcg
    12601 ggtgcaggct agcgcaccgg ccgttcaggc ggtccactgg gggccgcggc cggacgcgtc
    12661 gagcttgagt gcgaccggac gcttcgtatg attcatcaaa cctagccgat cgagcgcatc
    12721 ggggaacgca tgagcgagcc gacgatcgcc gcgccggggg cgcaccccct gcgcgcgctg
    12781 agcccgcgcg accgcaccgt gcaggaactc gtcgtgcggc agttccgcga tcgggccgac
    12841 gacccgctcc tgcgggggcc ggccgaccga acgtacgggg agacccaccg gcaggtggcc
    12901 ggggtggtcg cctggctcga ggctcgcgcg gtgggcgagg gcgagcgggt cgtggtcgtg
    12961 agcgagaacc gggtcgaact gctcgacctg ttcctcggct gcgcgttcgc cggggcgatc
    13021 tacgtcccgg tcaacccctt cctgcgcggc gagcagctgc gccaccagct cgaggatgcc
    13081 gcgcccacgc tggtcctgtg cgagcagggc acccacgacc aggtccgtga ggtgctgacc
    13141 gggttctccg acccacccga actgctcgtg ctgggggagg ggacctggga gctcgatggc
    13201 gccacgccac cgcggccgtc cacgcgcgag ctctccgccg gtcacccgcc cagccacccc
    13261 accggggtgc tctacacgtc cgggacgacc gggccctcca agggagtggt ctgccccgcg
    13321 ggccagttct tctggtgggg ggtgctgacg gccgagtacc tccggctgcg gccgtccgac
    13381 cacctctaca cgaccctgcc gctctaccac atcaacgcgc tcggggcgta cctgcaggcg
    13441 atcggggtcg gcgcctccta cacgttccgg cgcgggttct ccgcgtcgcg attcatcgcc
    13501 gaggcccggg aggcagaggc cacggtcacc tatctgctcg gcgcgatgct cacgatcctc
    13561 tggaagcagg aaccgagcga gcgggaccgc gagcacgatc tacgggtggc cctcgcgccc
    13621 gccaccccgc cggacatctt cgaacgcttc cgggagcgct tcgggttcga cctcgtcgac
    13681 ggcttcggca tgaccgagct gaacctcgtc gtctcctcgc tcccggaagc cacccgcccg
    13741 gggcgcatgg ggtgggtgct cgacgacttc gaggcgcgtg tcgtcgacga cgaggacatc
    13801 gaggtctccg acggcgagcc cggtgagctg gtggtgcggc cgcgggagcc gcacagcatg
    13861 tgtcagggct actggcgccg gccggaggcg acggccgagg cgtgggccaa cctctggttc
    13921 cacacccagg accgcgtggt gcgcgacgac gacggcgcgc tgcgctacct cgaccggatg
    13981 aaggacgcga tccgccgacg gggggagaac atctccagtt tcgaggtcga ggcggtcgtc
    14041 gcgaaccacc cggcggtcgc cgaggcggcc tgcatcgggg taccgtccga gctcggcgag
    14101 gaggaggtca tggtccacgt ggtgccgcag ccgggcgagc agccatcggg cgaggacatc
    14161 gtgcggtggt gcgccgaccg tctcgcgcac ttcgcggtgc cgcgctacat cgcggtcgtc
    14221 ggcgacctcc cccgcacgcc gaacgggaag gtgcgcaagg ccgcgctgcg cgaacagggc
    14281 gcggccaccg ggacgttcga ccgcgaggcg gcgggcgtcg agatccggcg cggctgagcg
    14341 acgggacgtg acggggatgc gggtgcggcg gttcgatcgg gcgggcatca ccgggctcgc
    14401 cgagttgccg gtccgcgtgc gcggcgagac ccggcagacg atcgagctgc tcggtgaggc
    14461 cgcgcgcggt gcggtcggcc gtgccggcgt cgcatgggag gacgtcgacg gcctcgcgct
    14521 cggggggttc accctcgggc cggatggggc ggtgcacgtc gcgacccgcc tcgggttgca
    14581 gccacggtgg ctcgcccccc aggacccggg gggcgcgagc ggggtcgcgg cggtgctcgc
    14641 ggccgcgcgc gcggtcgagg ccggcgacgc cgacgtcgtc ctctgcgtcg ccggcgacgc
    14701 gctcgacggg cccgccctcg tcgacctcgg caagcgcttc agcgcggaca cccgcgattg
    14761 gctgaccccg atcggggccg agcccgcgaa cgtcacgttc gcgctgctcg ccgaccacta
    14821 cctgcgggcg cacgggctca cccgcgccga catgggcgtg gtctcggtgc tccagcgccg
    14881 tcacggcgcg atgaatccga acgcggtgtt cggtgacccg atcgcgctgt tcgactacct
    14941 cggcgcgccg ccggtcgcca cgccgctgca ccttctcgac tgcgtgcgcc cggggtcggg
    15001 cgccagcgcg gtggtggtgc agaaggtcag ccggcggcgg tcgtcacgac cgcgcggggt
    15061 tcgggtgctg gcgggcgcgg aggcccacgg cgcggcgccc gagtggccgc cgcgcgagct
    15121 gggctggcgc gggttcgtcg acgacctctt cgatgcggcc gggatgatcc acgacgacct
    15181 cgacgtgctc gagctctacg acgactatcc cttcatggtg ctctggcagc tcgaggaact
    15241 cgggttctgc gcgcccggtg gggcctccgc gtggctgcgc aaccacgatc tcggtgtcgc
    15301 cgcgcccccg gcgctgaaca ccggcggcgg catgctcgcg tgcgggcagg ccggcgccgc
    15361 cggcgggtac gtgcccgtcg tcgaggcggc tcgacagctg ctcggcacgg cgggcacccg
    15421 acaggtgccg ggagcgcgcc gcggtctggt gagcgggctc ggcatggtcc ggtacggcgc
    15481 gccgttgtcg gtgagcgcga tgatgctgga gacgatcccg tgagccgggt ggtgccatga
    15541 gtcgccgctc cgaggagatc gcctcgctcg acacgctgcg cgagcgctgg ctcaccgccg
    15601 cgcgcgaggg gccgccgcgg ttcccggcct gcgccggttg ccaggcctgg tcctggcccc
    15661 cgacggtcgt ctgccccgtg tgcggggagg gacgctggag gctcgtgagc gtgccaggca
    15721 cggggctcgt ccgtgccgcg acgaccgtgc atcgcggcgt cgcgccggag ttcgcggacg
    15781 aagcccccta ccgggtcggc gcggtcgccc tggacgacgg ccccctcttc ctgacgcgcc
    15841 tcgacgtggg ggtgcatcag ggctcacggg tgcgactgcg ctggcgcgac cggcccggcg
    15901 acgggtggct gtgggcgagt gccggcgcgt agtccgtgcg cgggctcccc ctggatgcct
    15961 cggcgcgctc gcgggcgccg ggcgtgacgt gtcaccgagg gtctgctcgg agagtggccg
    16021 cgcgaaagtc gttgaccgaa gtgatcaaat attgaacact tgatcgtgat cggtcaggca
    16081 ccgcccggcg aaccgaggca ttcggaccga gctctccgac cggcgacccg ggaacttggc
    16141 gccggtcgga gggctgtgcg aggtcccgga agtaggaggc tgaggccaca tgcacacgac
    16201 caggaccccc gcacacccgc ggatcccacg tcgccctcgc gcggcgctgc tcgtcgtggg
    16261 gcttctcgcc ctcgcgctcg cgctcgcggc gtgcgccgag gacgaacccg acgacgccgt
    16321 cgacgagccc gacgatgacg tcgaggaacc cgaggacgag cccgacgacg acgacgacga
    16381 cgccgccgac gatcctgccg acggcgacgc cgacgaaccc gacgaggacg ctgacgatcc
    16441 cgaggacgaa gccgacgagg acggcgacga gcccgaggag gtgaccctcg agttcgtgac
    16501 cgcgtgggag gatgactcgg acgaggtcca ggggttctgg cagttcgccg agcgcctgga
    16561 ggaggaggcc ccctggatcg agctggagta ccggggcggc cccgagacct tcccgaacga
    16621 tcaacagggt gaggcggtcc gggacggtgc ggtcgacatg tccgtcgtgg cggcaaccta
    16681 ctacacgcag aacatgccgt tcgcacacgc catgaagctc acgcccttcc tgcccgagga
    16741 ggagcgcgag cacggcatct acgacctcta ccgggagcag caccgcgaac acctcaacgc
    16801 gcactacctc ggcaagacga aggcgaacac gccgttcttc ctgtactcga acgagccgat
    16861 cgagtccgcc gacctgagcg gcttgcgggt gcgcgtgtcc ccggtctacg aaccgttggt
    16921 gcaggagctc gacggttccg cggtctccat ggcccccgac gaggtctaca ccgcgttgga
    16981 gcgtggcgcc gtcgacgcgt tcggctggcc ggcgaccggt gtcaccgacc gcggctggga
    17041 ggaggtcacc gagtacgagc tgcggcccgg cttctacgag ctggacgtcg gcgtgatcgt
    17101 gaacatcgat gtgtgggagg gcctcgacga gcggacccgg gaggccatga ccgacgcgat
    17161 ggaggagact gagcgcgaga tccccgactt ctacgaggag tccctcgagg aggaggtcgc
    17221 cgaacgcgag gcggcgggca tggagatcat cgagctgccc gacgacgagg ccgaggcctt
    17281 cctcgaggcc gccgatcggg ccggctggga ggacgcgatc gaacaggccc cggaggccga
    17341 ggagttccgc gagctcatcg aggagatcga gggcgagtaa gcgcgggccg cgcccaaaga
    17401 cgcgtgccag agaggggagc catgggcctg cggagcccgt ggggcccgct cgagaccgtc
    17461 gagcgggccc tcaccgccgt cggggcgatc atcctcgcct ggctcgcggt cagcatcacg
    17521 gtcgcggtgc tctcccgtca cttcgccggg gagcccatcg ggtggacctt cgagatcgcc
    17581 gagtacagcc tcgtcgtcat cacgtttgct gcgatcgcgt tggtggggcg cgaggacggt
    17641 cacgtcagga tggagctgct cggtgaggtg ctgccgcagc gggtccagcg cgttctcacc
    17701 ctgatcgccg agaccatctc cctgctcgtg ctcgccgccg ccttcgtcgc agcggtggcg
    17761 atcaccgccg agaacctcgc cgatgggacg cgcgtcagcg gcatcctgcg catcccgcgc
    17821 tggttggtgc tcgcgatcat gcccgtcggc ctcgggctcc tcgcgatcga gcacgggaaa
    17881 cgcctggctc gcgccgtgcg gccgggctcg accgggtggg ccggctcgac cggctccgcc
    17941 gcggatccgg acacccaggg gtagcggtgg agtggcccct cctgctcgcc gccttcctcg
    18001 gtgccctgat catcctcctg ctgctgcgcg tccccgtggc catcgcgctg ctgggcgtga
    18061 acctcgtggg ggtcgtctgg ctgttcggct gggacgcggg aacgcgccag ctggtgctga
    18121 gcgtgcaggg gggcttgtcc acgttcgtgc tgtcgccggt cccgctgttc atcctcatgg
    18181 gcgaggtgct catggcctcg ggcctggcga gccgcgcctt gagcgcggtg gagcgcagca
    18241 tgggcagact ccccggccgg ctggggctcg tcaccaccgc ggggggcacc ctgttcggca
    18301 tcctgtcggg atcgacgctc gcgaacaccg cgttgctggg caaggccttc ctcccccaga
    18361 tgctgcgcga gggctacggg gtgcgttacg ggatgggctc gatcctcgcc tccggtggcc
    18421 tggcgatgat catccccccg agcgcgctgg cggtcgtgtg gggggcgaca gcgggcgtgg
    18481 cgatcgggcc cttgctcatc gggggtctgc tccccgggct gctgatggcg gtgaactacg
    18541 cgatcgtcct catcggctgg agttggctgg cgggccgacg atcgcgtcgc tcggcgccgg
    18601 tggtggcgac cgagggggcg accgaggggg cgacggtgga gggccgcgtc gagcggtcgg
    18661 gggaccagga ggcgacccgc gaccacgaga cgcccgatgc ccctccctcg ttgttggtcg
    18721 acgtcgcccc gctggccctg ctgatcgcgc tggtcctggg cctgatcttc ttcggagtcg
    18781 cgaccccgac cgagtcggcg gcggccgggg cggtgggctc ggtcgtcctc gcggcggcct
    18841 accgccgatt gggccgcgcc acgatgtggt cggcgctggt cggcagtgcg aaggtgtcgg
    18901 cggtcatctt cttcatcctg gccggctccg acgtctacag ccgcatcatg agcttcagcg
    18961 gcgcgacgtc cggcgtgatc ggcgcgctgc tcgacgtcga cgcgggcccg atcgtgaccc
    19021 tgatcctgat gcaggtcgcc gtcgtgctgc tggggctgtt cctcgagcag atctcgatca
    19081 tgctcgtgac gctgccgttc ttcatgccgg tcgtggaggc gatgggctgg cacccggtct
    19141 ggttcgggat catcatgctc atcaacctgc agatcgcgct cacgacaccg ccgttcggga
    19201 tgagcctgtt cgtgatgaag ggcgtcgcac cgcgcggggt caagctcacc gacgtctacc
    19261 tcgcggccgt gccgttcgtg ctcgcggacg tcgtcgccat cgcgctgctc atcctcgtac
    19321 ccggcatcgc cctctggttg cccgagctca tgctctgacc gttcgtcgcg ggcggggagc
    19381 gaacccccat gtcgaaggag cccaccgtgt caaccgaagc gatcgacctc cccggtctcg
    19441 gggccctcac cgtcgtggat ctggcgcagc cgctgaccga gacgacgccg accatccaac
    19501 tgcccgagcc gttcgcgaac acccccccgt tccgactgca cgagatcagc cgttacgacg
    19561 aacgcggacc cgtctcctac tggaactggt tcgagtgcgg cgagcacgtc gggacccacc
    19621 tcgacgcgcc caaccactgg gtctcggggc aggggggtcg cccggtcgac gagatcccgc
    19681 tgcggcaact cgtcgcaccg gcggtcgtga tcgaccgcac cgacgaggcg gctgccgatc
    19741 ccgactacct gctggggctc gaggacgtgc gcgcgttcga ggcggagcac ggcccgctgc
    19801 cggagggcgg ttggctgctg taccggaccg gttggagccg gtacgcccag gaccaggaac
    19861 agttcctgaa cgcggacgag agcggcgcgc acacccccgg catccaagcg gagtgcgccc
    19921 ggtggctggc cgaggagagc ggcatcatcg ggatcggcgt cgagaccgtc ggcaccgatg
    19981 cggggcaggc cttcgagctc gatcccgtct ttcccgtgca ccactacatg cacggtgcgg
    20041 gcaagctggg gctgacccag ctcgcgaacc tcgatcggct ccccgcgacc ggcacgaccc
    20101 tggccgccgc gccgctcaag atcgagggag gctcgggcag cccgaccagg gtctacggct
    20161 tgctgccgcg ttgaccgacg cgcacgccgg gtctccggga ttgccctggc acggggggcg
    20221 aaccccgggc gatgggctcc tcgctacccg tcgggctccc atgccaccgg caacctgctg
    20281 aggccgcggg cgaagaagat cgtgtcgcgt tcgggctcgc cggccaggcg cgggccgggc
    20341 aggcgccgca ggagcttcgt caaggcgatc cgcagttcca ggcgcgccag gggcgcgccg
    20401 atgcagacgt ggatccccgt gccgaacgcg aggtgcttgc ggacacccgc gcgctcgagg
    20461 tcggcctcgt cgggatcctc gtagcggcgg gggtcccgat tcgccgagcc gtagtgcagc
    20521 atcacccggg cgccggcggg gagcgtgacc ccgtcgacct cgacctgcct ggtggtggtg
    20581 cggaacaggc cctgcgcggg ggactcgagc cgcaggaact cctccacggc cgcgggcatc
    20641 cgctgttcca ggtcggcctc gagcgtctcg cgcagccggg ggttctggaa gaggagcagc
    20701 agggagttgc cgatcgcgcg cgtcaccgtc acgtgtccgg cgatgatgag gttgagcgga
    20761 acccagaggg cttcctccag cgagaggggt cgctcgccct cgagccgagc ctcgagcagg
    20821 gcggacatga ggtcctcggt gggctgctcc tgccgcgctt cgagctcccg catcaccaac
    20881 cgctgcagcg cgacgaagct ctcggcgtag gcgacctggt cctcgaccgg gtcggtggcc
    20941 tggatcagct tgagccagtg gtagctccac aggtggaggt cctcgaggtc cgcacggttc
    21001 aggccgagca tgtcggcgat ccctgcgagc gggtacggcc aggcgaaacg gtcgatgagc
    21061 tcggcctcac cgtcgctggc gaatccggcg atgagctcct cggcgagttg gtcgaggcgt
    21121 ggctccagca tcgcgacgcg cttgggcgtg aacgcctggt tcacgagccc gcggaggcgc
    21181 cggtggtagg gctcgtcgct gtcggtgagc gtccccagct gtgggtagcc ctcggcgagc
    21241 accgcctcga cctcgggcgg cggcgtcgcc atcgaggatc gcaccgcgtg ccgcgacgag
    21301 aaggtctcgt ggtccctcgc tgcggcgagg acgtcctcgt agcggctgat cacccagaga
    21361 tcgaacggct cggcgtagaa gacgggcgcc tcgtcccgga gttgttcgta gatcccgtag
    21421 gggttctcca gctgttcggg gctcaggggg tcgaaccgca gcgggtgcgg ctcgccgagc
    21481 gcggaccgac gggccatgga gggcactcct tgtgcgtggc cgaccgttca cctggtcgga
    21541 agtgggtggt cccgggggcc gtcagtcgcc ggtggtcgat gcccacggga cgaggagtcg
    21601 ttcgagtgca acgagcccgt agaacagcgc gacgctcatc gcgctgagca gcaggatgga
    21661 cgcgaaggcc agtgaggtgt tcgccgttcc gccagcgatg atgacgacga acccgaggcc
    21721 cgcgtcagcg ccgctgaact cacccacgac cgccccgatc acggcgaggg tcatcgcgac
    21781 cttcaggccc acgaacgtct ggggcagggc ggaggggaag cgcaccttgc ggaagatctg
    21841 ccattcggac gccttgagcg agcggctgag ctcgatgaac tcctcgtcgg tggatttgag
    21901 gccggctgcg cacgacacca cgatcgggaa gatgcagatc aggatgatga ggatcacctt
    21961 gggcaggatc ccgaacccga gccacatcac caggatgggc gcgatcgcca ccttcgggac
    22021 ggattgtgcg gtgacgagca gcgggtacag ggttcgctcc gcgatcctcg agtaggcgat
    22081 caggaacgcg agcgggaccc ccagcacgat ggctgccgcg tagccgagga gtgtctggcc
    22141 gagggtggtc aggaagtgcc cagtgaggct ctcggcgtcc tccagcaacg tggcggcgat
    22201 ggaggtgggc gcggggagcg tgaactcccg gacgcccagt acgcggacga ggagttccca
    22261 cagcaggatc aatccgacca gcaacgcaac gggggccatc cccgcgccca gtcgttcccg
    22321 ggcgcggcct cccgctgcgc cggtcgtcag caccggtgtc cgctcactca cggtcgggcc
    22381 ttgacgtcga ttgctcgtcc ggcgggaccg ggtcgccgat cagctctcgg cgcacgcgtt
    22441 ccgcgtgatc ggcgagctca ggagagttct cggagcgcgg tctggacgcg tcgatcggct
    22501 ggacggatcc tatgcgcccg gggcgagggg tcagcgtgac cacgcggtcg gacagcgtga
    22561 ccgcctcggt gatgctgtgc gtcacgagga cgatcgtctt cgtcgtctcc agccagatcc
    22621 gttgcagctc ctggctgagc tcttcgcgcg tcagggcatc cagcgcggcg aacggttcgt
    22681 ccatgaggag gatgtccgga tcgtgcacga gcgcgcgaca cagggcagcg cgttgctgca
    22741 tccccccgga gagcgccttc ggccgccgat gctcgaagcc gcccaagccg accatgtcga
    22801 gcagggcgcg ggcccggtcg aggtgtgcgt cggacgtgcc gccgaggatc tcgaccggga
    22861 agaggacgtt ctcgaggacg gtccgccagg ggaacagcgc cgggcgctgg aacatgaggc
    22921 cgacgtcctc gcgcggcccc gtgacgacct cgtcggcgac ggacaccgtc cccgccgtcg
    22981 gggggatcag tccggcgatg agccgcagca aggtggactt gccgcagcca gagcgcccga
    23041 ccagcgacac gaactcgtgc cggccgacat cgaggtcgat tccgtggagc gcgtcgaccg
    23101 ccccggcggt cccggggccg aaggtcttgg acaccccttg gagtcggagc agcgccgtcg
    23161 agtgttccac gcggacgtcc cgttctcttc ttctcgccga agcgggtctg acgcgctcag
    23221 gagctcaggg tgccaacggc tcgtagacct cgtccaggga caccggttgc tccagttcga
    23281 aggcctcctc ggccgtgtcc agcagcgatt cgaggcgtga ctcgtcgatg tgtccgagac
    23341 cgtgctcctc ggtgtagtcg gtcacgacgt agtcgcgcat gatctcgagc tctcgggcgg
    23401 cgatgtcgac atccacttcg tcgacccgct cctccatgac cgtcgcagcc tcctccgggt
    23461 cgtccagggc ctcctggagg ccgtggttga gggcggtgac gaacctggtg atcagctcgg
    23521 gatcctcctc gatgaggtcg tcgctggcag cgatgccgag accggggagg tcggggatgt
    23581 ggtcggcgta ggggaaggcg acgatgtcgt catccgtggc ctgctcgaac agcgggatgc
    23641 ccaccacgaa ctgctgcacc gcgtccgcct ctccaccggc caggatctgc ggcagctgtg
    23701 gaggctcggt ggggcggaag tcgacggcgt cgccatcgaa tccggccgcg tccgcgtagg
    23761 gaccgaacag cagggtgtcg gcacccgccg gggctccggc gagggtccgg ccctcgagct
    23821 cgcccggctc ctcgatcccg gcgccctccg gggcgaggat ggccgtcaac gcgtcctggt
    23881 gcacgaagct cacgatcttc acgggcacct cctcgttggc ccggacgatc gccgtggacg
    23941 cgaaatcgat cggtgcgaac tccagttggc cctgggcgat gagctgtgcg ttgtcgacgg
    24001 accctccacc ggggacgatg tccacttcga ggccggcgtc ctcgaagtgg ccgtgtgcgt
    24061 cggcgacgta gacgtaggcg tcgcgcccga acgtgccgaa cgacgtcgcg taggagatct
    24121 cggtgaccgt gtcggcctcc gcgtcgtcgg ccggagtatc ctcggcgccc tcggtcgcgc
    24181 atgcgcccac gccgagcgcg acgacgacgc cgctcaaggc aagcagtacc ctccgcgagt
    24241 atggcatgtt aacccccaaa tggacatgga tttgctgtgg aggcctgaca cctcaggcga
    24301 gacctccaac gagatggatc gttcggatct gaaacac
//
