LOCUS       NZ_SHKU01000005        22160 bp    DNA     linear   CON 27-MAY-2024
DEFINITION  Streptomyces sp. BK022 Ga0307664_105, whole genome shotgun sequence.
ACCESSION   NZ_SHKU01000005
VERSION     NZ_SHKU01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. BK022
  ORGANISM  Streptomyces sp. BK022
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 607918)
  AUTHORS   Kalluri,U.
  TITLE     Understanding the reciprocal impacts of modified plant cell wall and
            associated microbiome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 607918)
  AUTHORS   Kalluri,U., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 215.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004217355.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 02:58:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,482
            CDSs (total)                      :: 6,401
            Genes (coding)                    :: 6,280
            CDSs (with protein)               :: 6,280
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 49 of 121
            Pseudo Genes (incomplete)         :: 92 of 121
            Pseudo Genes (internal stop)      :: 16 of 121
            Pseudo Genes (multiple problems)  :: 29 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:05:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 241920
            Orig. end                         :: 264080
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SHKU01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22160
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="2"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22160
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22160
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12160](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12160)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            69..2216
                     /gene="glgX"
                     /locus_tag="EV284_RS22215"
                     /old_locus_tag="EV284_4456"
     CDS             69..2216
                     /EC_number="3.2.1.196"
                     /GO_function="GO:0004133 - glycogen debranching enzyme
                     activity [Evidence IEA]"
                     /GO_process="GO:0005980 - glycogen catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glgX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019981800.1"
                     /locus_tag="EV284_RS22215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4456"
                     /product="glycogen debranching protein GlgX"
                     /protein_id="WP_130336942.1"
                     /sec_met_domain="CBM_48 (E-value: 4e-17, bitscore: 57.3,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 1.1e-15, bitscore:
                     53.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQVWPGEAYPLGATYDGAGTNFAVFTEAADRVELCLLHDDGSETA
                     VELRESDAFVRHAYLPGVMPGQRYGFRVHGPFAPERGLRCNSAKLLLDPYAKAVSGSVQ
                     WGEEVYGYHFDAPDRRNDLDSAPHTMSSVVINPYFDWGDDRPPRTDYHRTVIYEAHVKG
                     LTMRHPGLPDELRGTYAGLAHPAVIEHLTRLGVTALELMPVHQFVNDHRLVDMGLNNYW
                     GYNTIGFFAPHNAYASWGDRGQQVLEFKSAVRALHEAGIEVILDVVYNHTAEGNHLGPT
                     LSFKGIDNPSYYRLTDDPRYYMDTTGTGNSLLMRSPHVLQLIMDSLRYWVTEMHVDGFR
                     FDLAATLARQFHEVDRLSSFFDLVQQDPVVSQVKLIAEPWDVGEGGYQVGNFPPLWTEW
                     NGKYRDTVRDLWRGEPRALAEFASRLTGSSDLYQDDGRRPLASINFVTCHDGFTLHDLV
                     SYNDKHNDANGEDNRDGESHNRSWNCGVEGDTDETEVRELRGRQMRNFIATLMLSQGVP
                     MISHGDEFARTQRGNNNAYCQDNEISWVDWPDPEDAVEATGAEGDERAALLEFTRAMVG
                     LRSEHPVFRRRRFLHGRPVEGTQDELSDVAWFTPEGEQMAQADWDSAPASALAVFLNGN
                     AISEPGPRGERIADDSFLLMFNASHETLDFLVPVDHGRQWQVVVDTARPEGVPPGQGPK
                     VAAGDHLTLPDRSLTVLQRPA"
     gene            2338..4707
                     /gene="treY"
                     /locus_tag="EV284_RS22220"
                     /old_locus_tag="EV284_4457"
     CDS             2338..4707
                     /EC_number="5.4.99.15"
                     /GO_function="GO:0047470 - (1,4)-alpha-D-glucan
                     1-alpha-D-glucosylmutase activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257: Alpha-glucosidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004981866.1"
                     /locus_tag="EV284_RS22220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4457"
                     /product="malto-oligosyltrehalose synthase"
                     /protein_id="WP_207229106.1"
                     /sec_met_domain="Alpha-amylase (E-value: 4.9e-16, bitscore:
                     54.2, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSVRPGPGVPTATYRLQLQPSFPFAAAEASVPYLASLGVSHLHL
                     SPVLEAVPGSTHGYDVVDHARVRAELGGEDGLRSLSRTAREHGLGLVVDIVPNHMAMAP
                     RYNRALWEVLREGPESPYARWFDIDWASRGGQVLLPVLGGPISAEREHLVAEGELLRYH
                     DHLFPLRSGTEGLPLPELLDAQWYRPVWWRLARTELNYRRFFSISELIGVRVEDPEVFD
                     ATHGKILQLLAEDVIDGLRIDHPDGLADPDAYLARLDEATGGRWTVVEKILADEEQLPD
                     SWPVAGTTGYDALRRIDGVFTGPAGAAELEAHYRGFAAPQLDRGGDWDATVRRAAYKVL
                     THELAAEADRLTRSAVRLCAASPDLALRDRAPWALRTALEELLVRMPVYRPYTSGDAAA
                     VVTEEAAAEARRAFAVAEEADAVDLVRGLLIGPDHGTLPELTEFRARFAQTASALRAKS
                     VEDTAFYRYVPLLSATEVGGDPGRPGVSPAEFHAYCARVASHWPDTGTVVTTHDTKRSA
                     DVRAALNVLTECPGRWAKLLAEVSREPEVVPDGQLAWAAWQTVFGLGPAEEERVREALL
                     KHVREAGMYTSWTEREAPYEDAVAAFVATGPCGPPGERVAAFRKGLEPHIRANVLGTAL
                     VHLTMPGVPDLYQGTESEYRALVDPDNRRPVPFPPAAPGEKEALTRAALRLRARRPEVF
                     GREGAYAPLLAEGPSAEHVLAFSRSGEVIAAATRLSVHLEEAGGWRDTRLTLPPGRWRD
                     VLAPDREFTGEVRAEELFSALPVGLLERVDEAGDVV"
     gene            complement(4768..5166)
                     /locus_tag="EV284_RS22225"
                     /old_locus_tag="EV284_4458"
     CDS             complement(4768..5166)
                     /GO_function="GO:0004867 - serine-type endopeptidase
                     inhibitor activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019071457.1"
                     /locus_tag="EV284_RS22225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4458"
                     /product="SSI family serine proteinase inhibitor"
                     /protein_id="WP_130336944.1"
                     /transl_table=11
                     /translation="MNRLTRTAALAAALMATCLLAPGTTAHAASGDWLSLTVTRPGTTG
                     GGTRAALLLCDPPQGHPKAAEACAELSAADGDFSRLGDSATLCPLIYAPVRASAHGRWN
                     GRRIDHERTYGNACELRAATGDVFALEG"
     misc_feature    complement(5166..5182)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
     gene            complement(5265..5816)
                     /locus_tag="EV284_RS22230"
                     /old_locus_tag="EV284_4459"
     CDS             complement(5265..5816)
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445381.1"
                     /locus_tag="EV284_RS22230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4459"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_130336946.1"
                     /transl_table=11
                     /translation="MTSSFEFPVHPVRVSDAERDKALRVLRDGVALGRLSHDTFVHRME
                     LVLAARSPRELAVLTADLKDGNRLSRALFGTVEAVSGFGVRLSRAWRAERLPKLLLPHP
                     AHGHPLRIGRDPASGLRLNHDTVSRVHAELRYQGGMWVLRDLGSTNGTTVNGRRVLGAV
                     AVREGDLVGFGTVSYRLAAD"
     gene            5989..7737
                     /gene="treZ"
                     /locus_tag="EV284_RS22235"
                     /old_locus_tag="EV284_4460"
     CDS             5989..7737
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CBM_48"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675705.1"
                     /locus_tag="EV284_RS22235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4460"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_130336948.1"
                     /sec_met_domain="CBM_48 (E-value: 4.6e-06, bitscore: 21.9,
                     seeds: 59, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase (E-value: 5.3e-11, bitscore:
                     37.6, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFEVWAPQADRVALQCEGATRAMEPDPRRTGWWTAEADAADGAR
                     YGFALDDGPVLPDPRSRRLPDGPEGLSAVVDQDRYAWRADWPGRGLPGAVLYELHVGTY
                     TPEGTLDAAAERLGHLRELGVTHVELMPLASFPGRHGWGYDGVAPWAVHEPYGGPEALK
                     RFVDRAHELRLGVVLDVVHNHLGPSGNQLPAFGPYFTETHQTPWGAAVNLDAPGSDEVR
                     AYFRDSALAWLRDYRLDGLRLDAVHALHDDRARHFLEELSESVDALAEEVGRPLFLIAE
                     SDLNDPRMITPRTEHGLGLHAQWNDDFHHALHTALTGEAQGYYADFARAPLAALAKTLT
                     GGYFHDGTYSSFRGRAHGRPLDRARLSGHRLLGYSQTHDQVGNRAQGDRLAATLSPGLL
                     ACAATLTLTSPLTPMLFMGEEWAAGTPWQYFTDHTDPELAEAVRRGRRREFASHGWAEE
                     DVPDPQDPATRDRSCLDWSEPERDPHARVLAWYRRLIALRHDRPDLTVPDLADTKVAYD
                     ESARWLAFRRGDIRVAVNLGKEPAAIPLGTGQLEILAAWDESVEPPGPDGMLQVPAESC
                     VVLSQP"
     gene            complement(7802..8713)
                     /locus_tag="EV284_RS22240"
                     /old_locus_tag="EV284_4461"
     CDS             complement(7802..8713)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675704.1"
                     /locus_tag="EV284_RS22240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4461"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_130336950.1"
                     /sec_met_domain="APH (E-value: 1.1e-17, bitscore: 59.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPPTPTPDTVRALVRSLLRSGTAKGPEVRPVAPEHPYTWWVGT
                     RYVLRLAPDREASVRLRRETRLRDLVRPHVPVVVPSAVAHGDWTPGLACTLDARLPGDY
                     GGGHEVSALGEADLAGLLTGLRAVPVRQTETLGVPHVAPRSLGALRRIAAHAAERLAAA
                     DEFDAGRLHQLTPSGAAQLAAQGGSAVLTHHRLTDEHVLISADGRVRAVLDWTGAALGD
                     PAEDIAALATSVGAPAAVRAATLAGYGPRPCLRGLWLARCDTVIALTEHLDTPAAGSPH
                     AALLRAWEPIMLERVTELKEKE"
     gene            complement(8769..9893)
                     /locus_tag="EV284_RS22245"
                     /old_locus_tag="EV284_4462"
     CDS             complement(8769..9893)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="EV284_RS22245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4462"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_130336952.1"
                     /transl_table=11
                     /translation="MTGSAPAIFTAEDYRARMARATGAAAEAGLGGLLVAPGPDLVWLT
                     GYAPPVTERLTLLVLVPGRDPVLVVPALEAPDAERAAGAPALTLLKWTDGEDPHSLTAE
                     LLDPKGGVGVSDNTWALHLLALQRALPDLHCAALTDALPMLRAVKDAAELELLAAAGAA
                     ADAAFEEIRKLPFAGRREDEVGRDLAGLLRRFGHSQVDFTIVGSGPNGANPHHEVGERV
                     IQRGDMVVLDFGGLKDGYGSDTTRTVHVGEPTEEERRVHDVVRAAQEAGFRAVRPGATC
                     QDVDRAARAVIEDAGYGPYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSIEPGIY
                     LPGRFGVRIEDIVTVTEEGGRRLNDTTREMVVVD"
     gene            complement(10001..12160)
                     /gene="cyc2"
                     /locus_tag="EV284_RS22250"
                     /old_locus_tag="EV284_4463"
     CDS             complement(10001..12160)
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675700.1"
                     /locus_tag="EV284_RS22250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4463"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_130336954.1"
                     /sec_met_domain="T1TS (E-value: 4.8e-82, bitscore: 271.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPHFYMPYPARLNPHLDEARAHSTEWARTMGMLEGSGVW
                     DQGDLEAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMFKRTPDRVAGKAH
                     LDRLPLFMPLDPAAPVPEPENPVEAGLADLWARTVPAMSADWRRRFAVATEHLLNESMW
                     ELSNIGSGRIANPVEYIEMRRKVGGAPWSAGLVEYATAEVPASVARSRPLRVLMETFSD
                     AVHLRNDLFSYQREVEEEGENSNGVLVLERFFGCSTQEAAETVNDVLTSRLHQFEHTAL
                     TEVPALALENGLRPDEVAAVAAYTKGLQDWQSGGHEWHLRSSRYMNQGARSETPWRVPS
                     GPGTSAADIRALLASAGAERLRAYRHVPYRQVGPSLLPDFHMPFPLQLSPHADAARQHL
                     VTWCHTMGILSEGVWDEDKLAAYDLALCSAGLDPDATPEALDLSAQWLAWGTYGDDYYP
                     LVYGNRRDLAAARLTTARLSGCMPVDGEPGTVPANAMERGLADLWARTTAPMSAEQRHT
                     LKAAVDVMTESWVWELSNQLQHRVPDPVDYLEMRRATFGSDLTLSMCRMGQGPAVPPEV
                     YRTGVVRSLENAAVDYACLLNDVFSYQKEIQYEGEIHNAILVVQNFFGIDYPDALAVVH
                     DLMTQRMRQFEHVIAHELPVLYDDFQLSGEARAAMDHYVLDLQNWLAGILNWHREVDRY
                     KAEWLGGRAHGFVPGQAPGRLQPTG"
     gene            12396..13499
                     /locus_tag="EV284_RS22255"
                     /old_locus_tag="EV284_4464"
     CDS             12396..13499
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675698.1"
                     /locus_tag="EV284_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4464"
                     /product="cytochrome P450"
                     /protein_id="WP_130336956.1"
                     /sec_met_domain="p450 (E-value: 1.4e-17, bitscore: 58.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPSPPPQHRLPHAPAPVSWQDEPGTADRPPGPGFWAVTRHADAL
                     RVLEDPVTYSSLPGPGELPLVRRLLSGQDPPQHTRLRDHAARALTPGRVGRFTATARER
                     ARTLLTRALDAARATDGVLDLATAVSDPYTALNLADLLGVPHADRRRLPGRTGPHTLDD
                     TTGYARRLVVHRRRYPDDDLTTVLAHNARLTSDELDMLVALLLTTGLAPMRDAAAGGLA
                     VLARHPEAYRGLREGTAELDPAIEELLRLHPPLRTLSRTAATDTDLSGRRVRRGDRVVV
                     SLVAANRDAEVFAAPDRLDLARSPNPHLSLGAGPHLCLGADFARLQLRVLHEEVLCALP
                     VLRLAGPVLPSGSGVTNGVASLPVRAG"
     misc_feature    12426..12428
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13476..14678)
                     /locus_tag="EV284_RS22260"
                     /old_locus_tag="EV284_4465"
     CDS             complement(13476..14678)
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547159.1"
                     /locus_tag="EV284_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4465"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_130336958.1"
                     /transl_table=11
                     /translation="MSDAAPTAPVIRADAPGSFPHRTLAERHPAIIRQVRAGLPYEPPQ
                     QRALDALLKNCTEGVIEPLPADAPDRERWQSWGMDTYAGRSWFDVPWLWAESYFYRRLL
                     GAVGYFGPGAWRGVDPFRPSKTGELDSAETDAELSALDGLRDRPAGDRDRALLSGSLWG
                     NRADLSFQLSSEGGERREAAPGLVADDSDLLWSLLPAGGTGTLCLVADNAGRELVPDLL
                     LIAALLTEPRIGHAVLHLKPTPYYVSDATTADVIDALHRLRSAGGLAGEYGDTLWSALG
                     DGRLVLRAHPFSCAPLPYTDMPDDLRADFAAADLTLFKGDLNYRRLVGDRYWPATTPFD
                     EVTAYFPGPVAALRTLKSEVVTGLSASTEAALEKAEGRKWLTSGTHAMIQVNPSAGPDG
                     Q"
     gene            complement(14700..15347)
                     /locus_tag="EV284_RS22265"
                     /old_locus_tag="EV284_4466"
     CDS             complement(14700..15347)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018564390.1"
                     /locus_tag="EV284_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4466"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_130336960.1"
                     /transl_table=11
                     /translation="MVRQLRAEQTRTTIITAAADLFDRQGYESTSLSDIVGHANVTKGA
                     LYFHFAAKEDLAHAILELQSVAARQVVSEVESRGCSSLEALMRATFALARLAVHDPVPR
                     AGLRLVTTNLPMRPPLRHPFTEWLEFASRKLHGAVRDCDVHAELDAGVVAHSLVCFFVG
                     TRVAGRTLEPPARLPRRVAEMWYLMLRSLVPVHRRPRYLALAAQLEREARTG"
     misc_feature    complement(15585..15605)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            complement(15852..17924)
                     /locus_tag="EV284_RS22270"
                     /old_locus_tag="EV284_4467"
     CDS             complement(15852..17924)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020498.4"
                     /locus_tag="EV284_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4467"
                     /product="DUF1906 domain-containing protein"
                     /protein_id="WP_165425611.1"
                     /transl_table=11
                     /translation="MPVPAALRRAIRISLTATATAAVLTGVALPAAHATEAAKSPARHV
                     TYRGHHFTVPAGWNTVDLDRAPHACVRFDRHTLYYGTPSADQNCPAHVVGRTEALLVQP
                     AGSRGAGQARTDRTAHQLAASDARIQLTGTYKSNPGLIEDIATDADLTPQAAAPARRAA
                     PTGRLTPSTLAATTVSSATTHYTGKGFDACAAPSASTMNTWNSASPYGAVGIYIGGAYR
                     GCSQPNLTASWVSQQASAGWHFLPIYVGVQASGISSPTSQGTSAADDAITQASSLGFPA
                     GSVLYYDMEAYSPSSSSSVLSFLSAWTKELHAQGYKSAVYSSSTSGISDLADHYGSGYQ
                     MPDVIYDALWNGNADTADPAVSSTLWANHQRVHQYSGGHTETYGGISINIDSDYLDVAP
                     ATSTVPHGTVWDRTRGSSGTWAGSASEVDDNDAITAVASAALPDGTLHTFTVVPGSGVW
                     ERVRSASGVWATSAVKIDDNDNITAVTAAALKDGTIHVEVMVKNSGVWDRTRNTDGTWT
                     TATKVDDNTSITRIAAAGLTDGTLHLESLVPGSGVWERVRGASGTWQTSATQIDSNGDI
                     TDLATAALPNGTQHLEAVVPGSGIWDRVRTAAGTWQSSSHLDTNGDITAVALAVLPDGR
                     MTADAVVPGSGVWDRSYSAAGTWQAAATKIDANTDIFAVQSTGLPDGTVHLHTLV"
     misc_feature    17952..17968
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.47"
                     /tool="antismash"
     gene            complement(17997..19025)
                     /locus_tag="EV284_RS22275"
                     /old_locus_tag="EV284_4468"
     CDS             complement(17997..19025)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040125.3"
                     /locus_tag="EV284_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4468"
                     /product="DUF6528 family protein"
                     /protein_id="WP_130336965.1"
                     /transl_table=11
                     /translation="MRSSTSPSASSSRSHSRRSLLLGGLGAALGIALPLGGNARAAAAP
                     PVLVGDQKARKVLLLDSTKTNWDPAADPSVVQWSFTPDGDSRYADLQPASSFTYVSEAK
                     ARTSGGSTLVLVTASYGFAAVVEYPTGERRWAGLVAGSGPGDDLNPHSIELLPDGNVAV
                     ACSNGNAVRVYAASQGPTATDYFTTPLTTAHGVHWDSGANVLWAVGGSKLAAYTVAGTP
                     AQPVLAEKTSLSVQLPTSDGHDVGAVAGSSDLLWVSTGSALYQYSKSARTFTPYGSTAC
                     GRGPWGGVKAVSNSGGTVLFTKPDGDLSPNWLTRYVRDASGTASPYALADGGIYKARWW
                     QP"
     misc_feature    19016..19030
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.49"
                     /tool="antismash"
     misc_feature    complement(19017..19030)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.25"
                     /tool="antismash"
     gene            complement(19037..19231)
                     /locus_tag="EV284_RS22280"
                     /old_locus_tag="EV284_4469"
     CDS             complement(19037..19231)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV284_4469"
                     /product="hypothetical protein"
                     /protein_id="WP_130336967.1"
                     /transl_table=11
                     /translation="MPAFRPVAAAVATLALGLTAAVGVHTVHASSVALTAVAAKERPAA
                     ATVELPVGTAVTPRDMIWQ"
     misc_feature    complement(19335..19348)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.38"
                     /tool="antismash"
     gene            complement(19339..19689)
                     /locus_tag="EV284_RS22285"
                     /old_locus_tag="EV284_4470"
     CDS             complement(19339..19689)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240991.1"
                     /locus_tag="EV284_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4470"
                     /product="hypothetical protein"
                     /protein_id="WP_130336969.1"
                     /transl_table=11
                     /translation="MYLVHARLCPPERGIPLSPEAPGLLRAVAGPEDRLEHVSVHPGVE
                     PSPVVGLWLRGLSLREAERTASALCLRALAAAPEFAGWSLLRAEVPLLAPLGHGLLWPD
                     EAPSEGSDQGGH"
     gene            19861..20844
                     /locus_tag="EV284_RS22290"
                     /old_locus_tag="EV284_4471"
     CDS             19861..20844
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017240990.1"
                     /locus_tag="EV284_RS22290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_4471"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_130336971.1"
                     /transl_table=11
                     /translation="MLTALGLDPVAEAVYRAMLAERADGVAELAGRLELAEDDVRRALD
                     QLSELSLVRASYTMPGSLHAVSPEVGLELLLARQQAELAAQQQRVATSRATAAQLIAEH
                     AALRPFAAPGVEQLTGIDEIRDRLARLTRQVAAEVMTLAPDGEHTPQSIAAARPLNNSL
                     LERGVRLRTVYLESVSNSPHTQEYLEWLSGRGGEIRTAATLPTRLIIVDRRHAVIPLSS
                     DDSAAGAVVLSGQGTLTALCALFDRIWQSAKPLGENGRRGPKGLTDIEEAALKLLADGH
                     TDEAIAKRLGVSPRTARRIATGLMQRLDARSRFEAGARAAQRGWLG"
     gene            21251..22111
                     /locus_tag="EV284_RS32795"
                     /old_locus_tag="EV284_4472"
     CDS             21251..22111
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS32795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV284_4472"
                     /product="hypothetical protein"
                     /protein_id="WP_165425612.1"
                     /transl_table=11
                     /translation="MLSRARGRVRVVALAAVPLAAAAAVGAVRYAADPAPSAAKVPVAT
                     AAPVAAESTGPEDWTTDTAPGSAPTAPSHSASASRSPSHSPSHSPSASRSPSGPAAGAA
                     PAVHALPAAKLPDAHRSAWKAIGPPRTRQTTHDVNVSECGSVHGAVGWRQQGYASKANT
                     PAIQDTFTFTSASAADAAYRTLLTAFDGCGHNLRAFQAQHGTPQDAVVTKTASITDGTA
                     YSRSWTAVAGISMPGRQTNHYYVVRRGALLTVVQYTQPGVVTTADPNHQDSGDRADLST
                     IAEHM"
ORIGIN
        1 ctcactttcg gggagactca ccgccaacgc gcccccatcg gggccccgca cctggaagag
       61 tcgagcgcat gcaggtctgg cctggagagg cgtatcccct cggcgccacc tatgacggtg
      121 ccggtaccaa cttcgcggtc ttcaccgaag ccgcggaccg agtggagctg tgtctgctgc
      181 acgacgacgg ctccgagacg gcggtggaac tgcgcgagag cgacgcgttc gtccggcacg
      241 cgtacctgcc cggcgtgatg ccgggccagc ggtacgggtt ccgggtgcac ggccccttcg
      301 cgcccgagcg ggggctgcgc tgcaactcgg cgaagctgct tctcgacccg tacgcgaagg
      361 cggtcagcgg gtcggtccag tggggcgagg aggtgtacgg ctaccacttc gacgcccccg
      421 accggcgcaa cgacctcgac tccgccccgc acaccatgag ttcggtggtg atcaacccct
      481 acttcgactg gggcgacgac cgcccgccgc gcaccgacta ccaccgcacg gtgatctacg
      541 aggcccatgt gaagggcctg accatgcgtc acccgggcct gccggacgag ctgcgcggca
      601 cctacgcggg cctcgcccac ccggccgtca tcgagcatct gacccggctc ggcgtgaccg
      661 cgctggagct gatgccggtc caccagttcg tcaacgacca ccgcctggtc gacatgggcc
      721 tgaacaacta ctggggttac aacaccatcg gcttcttcgc cccgcacaac gcctacgcct
      781 cctggggcga ccggggccag caggtgctgg agttcaagtc ggcggtacgg gcgctgcacg
      841 aggccgggat cgaggtcatc ctcgacgtgg tctacaacca caccgccgag ggcaaccacc
      901 tgggtccgac gctgtcgttc aagggcatcg acaacccgtc gtactaccgg ctgaccgacg
      961 atccgcgcta ctacatggac accaccggca ccggcaacag cctgctgatg cgctcgccgc
     1021 acgtcctgca gctcatcatg gactcgctgc ggtactgggt gaccgagatg catgtcgacg
     1081 ggttccgctt cgacctcgcg gcgaccctgg cccggcagtt ccacgaggtg gaccggctgt
     1141 cgtcgttctt cgacctggtc cagcaggacc cggtggtctc ccaggtgaag ctgatcgccg
     1201 agccgtggga cgtgggcgag ggcggctacc aggtgggcaa cttcccgccg ttgtggaccg
     1261 agtggaacgg caagtaccgg gacaccgtgc gggacctgtg gcgcggggag ccgcgcgcgc
     1321 tggcggagtt cgcctcccgg ctcaccggct cctccgacct ctaccaggac gacggccgcc
     1381 gcccgctggc gtcgatcaac ttcgtcacct gccacgacgg cttcaccctg cacgacctcg
     1441 tctcgtacaa cgacaagcac aacgacgcca acggcgagga caaccgggac ggcgagagtc
     1501 acaaccggtc ctggaactgc ggagtggagg gcgacaccga cgagaccgag gtgcgcgagc
     1561 tgcgcggccg gcagatgcgc aacttcatcg ccaccctgat gctgtcccag ggcgtgccga
     1621 tgatcagcca cggtgacgag ttcgcccgca cccagcgcgg caacaacaac gcctactgcc
     1681 aggacaacga gatctcctgg gtggactggc cggaccccga ggacgcggtg gaggccaccg
     1741 gtgccgaggg cgacgagcgg gccgcgctgc tggagttcac ccgcgcgatg gtggggctgc
     1801 gcagcgagca cccggtgttc cggcgccgcc gcttcctgca cgggcgcccg gtggagggca
     1861 cccaggacga gctgtcggac gtcgcctggt tcacccccga gggcgagcag atggcccagg
     1921 ccgactggga ctcggcgccc gcctccgcgc tggccgtctt cctgaacggc aatgccatct
     1981 ccgagcccgg cccgcgggga gagcgaatcg cggacgactc gttcctgctg atgttcaacg
     2041 cctcgcacga gacgctggac ttcctggtgc cggtggacca cggcaggcag tggcaggtgg
     2101 tcgtggacac cgcgcggccc gagggggtgc cgccgggcca gggtccgaag gtggcggccg
     2161 gcgaccacct caccctgccg gaccgcagcc tgaccgtgct ccagcgcccg gcgtagcgcc
     2221 cacggccggg gacacgggag ccgccgtgtc cccggctgtc cggttcgtgt gggccgtccc
     2281 gggccggatg ccccggcgga tgacacgaag agcggcaggc ggggtacgta gctctgcatg
     2341 acttcagtgc gacccggacc aggggtgccc acggccacct accgcctaca gctccagcct
     2401 tcgttcccct tcgccgccgc cgaggcgtcc gtgccctatc tggcgtcgct gggcgtctcg
     2461 cacctgcatc tgtcccccgt cctggaggcc gtccccggct ccacccacgg ctacgacgtc
     2521 gtggaccacg cgcgggtgcg cgcggagctg ggcggcgagg acgggctcag gtccctgtcg
     2581 cgcaccgcgc gggagcacgg gctcggcctg gtggtggaca tcgtgcccaa ccacatggcg
     2641 atggcacccc gctacaaccg cgccctgtgg gaggtgctcc gggagggccc ggagtcgccg
     2701 tacgcgcgct ggttcgacat cgactgggcc tcgcgcggcg gccaggtgct gctgccggtg
     2761 ctcggcgggc ccatcagcgc cgagcgcgag catctggtgg ccgagggcga gctgctgcgc
     2821 tatcacgacc atctcttccc gctgcgctcc ggcacggagg gcctgccgct gcccgagctg
     2881 ctggacgccc agtggtaccg cccggtgtgg tggcggctgg cccgcaccga gctgaactac
     2941 cggcgcttct tcagcatctc cgagctgatc ggggtgcggg tggaggaccc cgaggtcttc
     3001 gacgccaccc acggcaagat cctccagttg ctggccgagg acgtgatcga cggcctgcgc
     3061 atcgaccacc cggacggcct cgccgacccc gacgcctacc tcgcccggct ggacgaggcg
     3121 accggtggcc gctggacggt ggtggagaag atcctcgccg acgaggagca gctcccggac
     3181 tcctggcccg tggccggcac caccggctac gacgccctgc gccgtatcga cggggtgttc
     3241 accggtccgg ccggcgccgc cgaactcgag gcccactacc ggggattcgc ggcccctcag
     3301 ctcgaccggg gcggtgactg ggacgccacg gtgcggcgcg ccgcgtacaa ggtgctcacc
     3361 catgagctgg ccgccgaggc ggaccggctc acccgctcgg cggtccggct gtgcgccgcc
     3421 tcgccggacc tggcgctgcg cgaccgggcg ccctgggcgc tgcgcacggc cctggaggaa
     3481 ctgctggtac ggatgccggt ctaccggccg tacacctccg gggacgccgc cgccgtggtc
     3541 accgaggagg cggccgcgga ggcccggcgg gcgttcgcgg tggcggagga ggccgacgcg
     3601 gtcgacctgg tacgcgggct gctgatcggc ccggaccacg gcacgctgcc cgaactcacc
     3661 gagttccgcg cccggttcgc gcagaccgcg tcggcgctgc gggccaagtc ggtggaggac
     3721 acggcgttct accgctacgt cccgctgctg tcggcgaccg aggtcggcgg cgatccgggc
     3781 cggcccgggg tctccccggc ggagttccac gcatactgcg cccgggtggc gagccactgg
     3841 ccggacaccg gcacggtggt caccacgcac gacaccaagc gcagcgcgga cgtccgggcg
     3901 gcgctgaacg tgctcaccga gtgccccggc cgctgggcca agctgctcgc cgaggtgagc
     3961 cgggaaccgg aggtggtccc cgacggccaa ctggcctggg cggcctggca gacggtgttc
     4021 gggctcggcc cggccgagga ggagcgggta cgcgaggcgc tgctgaagca cgtccgcgag
     4081 gcgggcatgt acacgagctg gaccgagcgg gaggcgccgt acgaggacgc ggtggccgcg
     4141 ttcgtcgcca ccggcccctg cgggccgccc ggggagcggg tggccgcctt ccgcaagggg
     4201 ctggagccgc acatccgggc caacgtgctg ggcaccgcgc tggtgcacct gacgatgccg
     4261 ggcgtgcccg acctgtacca ggggacggag agcgagtacc gggcgctggt ggaccccgac
     4321 aaccggcgac cggtgccctt cccgccggcc gcgcccggtg agaaggaagc gctgaccagg
     4381 gcggcactgc ggctccgggc gcgccggccg gaggtcttcg gcagggaggg cgcctatgcc
     4441 ccgctgctcg ccgagggccc gtcggccgag cacgtgctgg cgttctcccg ctccggtgag
     4501 gtgatcgcgg cggcgacccg gctctcggtg cacctggagg aggccggcgg ctggcgggac
     4561 acccggctca ccctgccgcc cggccgctgg cgggacgtgc tcgccccgga ccgcgagttc
     4621 accggcgagg tacgcgcgga ggagctgttc tccgcgctgc cggtggggct gctggagcgg
     4681 gtggacgaag cgggcgacgt ggtctgagcg agtggggcgg gccgggtggc gcggggacgc
     4741 gggaggagcg cgccaccggc ctcgccgtca gccctccagg gcgaacacgt cacccgtcgc
     4801 ggcacgcagc tcgcacgcgt tgccgtaggt ccgctcgtgg tcgatccgcc ggccgttcca
     4861 gcggccgtgg gcgctcgcgc ggacgggcgc gtagatcagc ggacagaggg tggcgctgtc
     4921 gcccaggcgg ctgaagtcgc cgtcggcggc gctcagttcg gcgcacgcct cggcggcctt
     4981 cgggtggccc tgcggcgggt cgcagagcag cagggcggcg cgggtgccgc ccccggtggt
     5041 gccgggccgg gtgacggtga gggagagcca gtcaccggac gccgcgtggg ccgtggtgcc
     5101 gggagcgagc agacaggtgg ccatgagggc ggcggcgagc gccgccgtgc gtgtcagacg
     5161 gttcatgccc ggtgcatcgg cacgtgagcc gggccgcgcc agcccggctc acccgaacgg
     5221 cagccaggag gcccgatacg ggcacaccag ttcggtccgg cgtgtcagtc ggccgcgagc
     5281 cggtaggaca ccgtgccgaa gccgacgagg tccccctcgc gcaccgccac cgcacccagc
     5341 acccggcgcc cgttcaccgt ggtcccgttg gtcgagccga ggtcccgcag cacccacatg
     5401 ccgccctggt accggagctc ggcgtgcacc cgggagaccg tgtcgtggtt gagccgcagc
     5461 ccgctggccg ggtcgcggcc gatgcgcagc ggatggccgt gcgcggggtg gggcagcagc
     5521 agcttgggca gccgctcggc gcgccaggcc cggctcagcc ggacgccgaa gcccgacacg
     5581 gcctccacgg tgccgaacag cgcgcggctc agccggttgc cgtccttgag gtcggcggtg
     5641 agcacggcga gttcgcgggg gctgcgtgcg gcgaggacca gctccatgcg gtgcacgaac
     5701 gtgtcgtgcg agagcctgcc cagggcgacg ccgtcccgca gtacccgcag cgccttgtcg
     5761 cgttccgcgt cggagacccg tacgggatgc acggggaatt cgaaggacga cgtcacgttc
     5821 gtgattgtcg ggcagcgcac cccggggtgt ccagcgaggc aaccggtgcc cgtggccgcc
     5881 cacttccgcg acacccgggc ggaaagcccc gattcgaaag cggactgatc gaattcgcgg
     5941 cacgatggac cgactgcatc acggtgagca gacgaagggg aaccgtccgt gaagttcgag
     6001 gtgtgggcac cacaggcaga ccgggtcgcg ctccagtgcg agggcgccac gcgggcgatg
     6061 gaacccgatc cgcggcggac gggctggtgg acggcggagg cggacgcggc ggacggcgcg
     6121 cggtacggct tcgcgctgga cgacgggccc gtcctgcccg acccgcgctc gcgccgcctg
     6181 ccggacggcc cggaggggct gagcgcggtc gtggaccagg accggtacgc gtggcgcgcc
     6241 gactggccgg ggcgcgggct gccgggcgcg gtgctgtacg agctgcacgt gggtacgtac
     6301 acccccgagg gcaccctgga cgcggccgcc gagcgtctcg gccatctgag ggaactgggc
     6361 gtcacccacg ttgagttgat gccgctcgcc tccttcccgg gccggcacgg ctgggggtac
     6421 gacggagtcg cgccgtgggc ggtgcacgag ccgtacggcg ggccggaggc gctgaagcgg
     6481 ttcgtggacc gcgcgcacga actccgcctg ggggtcgtgc tggacgtggt ccacaaccac
     6541 ctcggcccgt ccggcaacca actcccggcg ttcgggcctt acttcacgga gacgcaccag
     6601 acgccgtggg gtgccgccgt gaacctggac gcgcccggct cggacgaggt gcgggcctac
     6661 ttccgggaca gcgccctggc ctggctgcgg gactaccgcc tcgacgggct ccgtctggac
     6721 gccgtgcacg ccctgcacga cgaccgcgcc cggcacttcc ttgaggagct gtcggagtcg
     6781 gtcgacgccc tggccgagga ggtgggccgc ccgctgttcc tgatcgcgga gtccgacctc
     6841 aacgaccccc ggatgatcac cccgcgcacc gagcacggtc tcggtctgca cgcccagtgg
     6901 aacgacgact tccatcacgc cctgcacacc gccctgaccg gcgaggccca gggctactac
     6961 gccgacttcg cccgcgcccc gctcgccgcg ctggccaaga ccctgaccgg cggctacttc
     7021 cacgacggca cctactccag cttccggggc cgggcccacg gccgcccgct ggaccgggcc
     7081 cggctgagcg ggcaccggct gctggggtac agccagaccc acgaccaggt cggcaaccgc
     7141 gcccagggcg accgtctcgc cgccaccctc tcccccggcc tgctggcgtg cgcggccacg
     7201 ctcaccctga cctcgccgct caccccgatg ctgttcatgg gcgaggagtg ggcggccggc
     7261 accccatggc agtacttcac cgaccacacc gaccccgagc tggccgaggc cgtacggcgc
     7321 ggcaggcggc gggagttcgc gtcccacggc tgggcggagg aggacgtgcc cgacccgcag
     7381 gaccccgcca cccgcgaccg ctcctgcctg gactggtccg agccggagcg cgatccccac
     7441 gcccgcgtcc tcgcctggta ccgccgcctc atcgcgctgc gccacgaccg ccccgacctc
     7501 accgtgcccg acctcgcgga caccaaggtc gcctacgacg agtccgcccg ctggctggcc
     7561 ttccgccggg gcgacatccg cgtcgcggtc aacctcggca aggagccggc cgccatcccg
     7621 ctgggcacgg gccagctgga gatcctcgcc gcctgggacg agtcggtgga gccgccgggc
     7681 ccggacggca tgctccaggt accggccgag tcctgcgtgg tgctgtcaca gccgtaggcc
     7741 gccgccgggc gcggtggcgg gtaacgggag gtggtcgctc tccccgtgcc cgccggcacg
     7801 cctactcctt ctccttcagc tccgtgaccc gctccagcat gatcggctcc cacgcccgga
     7861 gcagcgccgc gtgcggggag cccgccgccg gggtgtccag gtgctccgtc aaggcgatca
     7921 ccgtgtcgca gcgggcgagc cagaggccac gcaggcaggg gcgggggccg tacccggcga
     7981 gagtggcggc gcggacggcg gcgggggcgc ccacggaggt ggcgagggcg gcgatgtcct
     8041 cggcggggtc ccccagcgcc gcgccggtcc agtcgaggac cgcgcgaacc cggccgtcgg
     8101 cgctgatcag cacgtgctcg tcggtgagcc ggtggtgggt gagcacggcc gagccgccct
     8161 gggcggcgag ctgcgcggcg ccggaagggg tgagctggtg caaccgcccc gcgtcgaact
     8221 cgtcggcggc ggcgagccgt tcggccgcgt gggcggcgat ccggcgcagc gcccccagcg
     8281 accgcggggc cacgtgcggc accccgagcg tctcggtctg ccgcacggga accgcccgca
     8341 gcccggtgag caggcccgcg aggtcggcct ccccgagggc ggacacctcg tgcccgccgc
     8401 cgtagtcacc cggcagccgg gcgtcgagcg tgcaggcgag gccgggcgtc cagtcgccgt
     8461 gcgccaccgc ggacgggacg acgacgggca cgtggggccg caccaggtcc ctgagccgcg
     8521 tctcccgccg cagccggacg gacgcctccc ggtcgggcgc gagccgcagc acgtaccggg
     8581 tcccgaccca ccaggtgtac gggtgctccg gtgcgacggg ccgtacttcg ggccccttgg
     8641 ccgtaccgct cctgagcagc gagcggacca gggcgcgcac ggtgtccggg gtgggggtcg
     8701 gtggccgggt catgggtcgt gtctcgccgt tccggaaggt cgtcgcggag gtggctgccg
     8761 gggtcaggtc agtccaccac gaccatctca cgggtggtgt cgttcaggcg gcgtccgccc
     8821 tcctccgtca ccgtcacgat gtcctcgatc cggaccccga accggccggg caggtagatg
     8881 ccgggctcga tcgagaagca catgccgggc acgagcggct gctcctcacc ctcgatcatg
     8941 tagggcggct cgtgcgtggt gacgccgatg ccgtgcccgg tgcggtggat gaagtacggc
     9001 ccgtagcccg cgtcctcgat caccgcgcgg gcggcacggt cgacgtcctg gcaggtggcg
     9061 cccggccgga cggcccggaa cccggcctcc tgcgcggccc gcaccacgtc gtgcacgcgg
     9121 cgctcctcct cggtcggctc gcccacgtgg accgtgcggg tggtgtcgga gccgtagccg
     9181 tccttcagcc cgccgaagtc gaggacgacc atgtcacccc gctggatgac ccgctccccg
     9241 acctcgtggt gcgggttggc gccgttggga ccggagccga cgatggtgaa gtccacctgc
     9301 gagtggccga agcggcgcag caggccggcg aggtcgcgcc ccacctcgtc ctcgcggcgc
     9361 ccggcgaagg gcagcttcct gatctcctcg aaggcggcgt cggccgcggc cccggcggcg
     9421 gccagcagtt ccagctcggc ggcgtccttg acggcccgca gcatgggcag ggcgtcggtg
     9481 agcgcggcgc agtggaggtc cggcagggcc cgttgcagag ccagcagatg cagcgcccag
     9541 gtgttgtcgc tgacgccgac accgcccttg gggtcgagca gctcggcggt gagggagtgc
     9601 gggtcctcgc cgtcggtcca cttcagcagg gtgagcgcgg gggcgcccgc ggcccgctcg
     9661 gcgtcggggg cctccagcgc gggcaccacg agcacggggt cacggcccgg cacgaggacc
     9721 agcagtgtga gccgctcggt gacagggggc gcgtacccgg tgagccagac caggtccggt
     9781 cccggcgcca cgagcagccc gccgagcccc gcctcggcgg cggcgccggt cgcgcgcgcc
     9841 atacgggcgc ggtagtcctc ggcggtgaag atcgcgggtg cactgccggt catccgggcc
     9901 tccgggtgtg gtcgtggcgg cggggcgtac ggccatcatg acgcgcgggg cgtacggcga
     9961 ccaccgggtt cccggtggcc gccggggcgt gacggcgccg tcagccggtc ggctggagcc
    10021 gccccggtgc ctggccgggt acgaagccgt gggcccggcc gcccagccac tcggccttgt
    10081 aacggtccac ctcccgatgc cagttgagga tgcccgcgag ccagttctgg aggtcgagga
    10141 catagtggtc catcgcggcc cgcgcttctc cggagagctg gaagtcgtcg tagagcacgg
    10201 gcagttcgtg cgcgatcaca tgctcgaact gccgcatccg ctgggtcatc aggtcgtgga
    10261 cgacggcgag tgcgtccggg tagtcgatgc cgaagaagtt ctgcacgacg aggatcgcgt
    10321 tgtggatctc gccctcgtac tggatctcct tctggtagga gaagacgtcg ttgagcaggc
    10381 aggcgtagtc gacggccgcg ttctccagcg agcgcaccac tccggtgcgg tagacctcgg
    10441 gcgggacggc cggaccctgg cccatccggc acatgctcag ggtgaggtcg gagccgaagg
    10501 tggcgcggcg catctccagg tagtcgacgg gatcggggac gcggtgctgg agctggttgg
    10561 acagctccca cacccagctc tcggtcatca cgtcgacggc tgccttcagg gtgtgccgct
    10621 gctcggcgct catcggtgcg gtggtccgcg cccacaggtc ggcgaggccg cgctccatgg
    10681 cgttggccgg gacggtcccc ggttcgccgt cgaccggcat gcacccggac agccgggcgg
    10741 tggtcagccg ggcggcggcc agatcgcggc ggttgccgta cacgaggggg tagtagtcgt
    10801 cgccgtacgt cccccaggcg agccactgcg cgctcaggtc gagcgcctcg ggcgtggcgt
    10861 cgggatcgag tccggcggag cacagcgcga ggtcgtacgc ggcgagcttg tcctcgtccc
    10921 agacgccctc gctcaggatg cccatggtgt ggcaccacgt gacgaggtgc tgccgggcgg
    10981 cgtcggcgtg cgggctcagc tgaagcggga agggcatgtg gaagtcgggc agcagcgacg
    11041 gcccgacctg ccggtagggg acgtggcggt aggcgcgcag ccgttcggcg cccgccgagg
    11101 ccagcagggc gcggatgtcg gcggcggagg tgcctggacc gctcggcacc cgccagggcg
    11161 tctcggagcg ggcgccctgg ttcatgtagc ggctggagcg cagatgccat tcgtggccgc
    11221 cggactgcca gtcctgcagc cccttggtgt acgcggccac cgccgcgacc tcgtcgggcc
    11281 gcaggccgtt ctccagcgcg agggcgggca cctcggtgag cgcggtgtgc tcgaactggt
    11341 gcagccgtga ggtgaggacg tcgttgacgg tctcggcggc ctcctgggtg gagcagccga
    11401 agaaccgctc cagcaccagc acgccgttgc tgttctcgcc ctcctcctcc acctcccgct
    11461 ggtaggagaa caggtcgttg cgcaggtgga cggcgtcgga gaaggtctcc atcagcaccc
    11521 ggagcggccg ggaccgagcg accgaggcgg gcacctcggc ggtcgcgtac tccacgagtc
    11581 ccgccgacca gggggcgccg cccaccttcc ggcgcatctc gatgtactcg accgggttgg
    11641 cgatccggcc cgagccgatg ttggacagct cccacatcga ctcgttgagc agatgctccg
    11701 tcgccacggc gaagcggcgg cgccagtccg cggacatggc cggaaccgtg cgcgcccaga
    11761 ggtcggcgag gccggcctcg accgggttct ccggctcggg gacgggggcg gcggggtcga
    11821 gcggcatgaa cagcgggagc cggtccaggt gggccttgcc ggccacgcgg tccggagtgc
    11881 gtttgaacat gtcgaggaag tggtcgtcga agaagaacac ccacacgtac cagtcggtga
    11941 tcagcgagag cgcggggccg tcgcagtcgg ggtgggtgta ggcgcacagc aggccgtagt
    12001 cgtgcgcctc caggtcgccc tggtcccaga ccccggagcc ctccagcatg cccatggtcc
    12061 gtgcccactc ggtggagtgg gcacgggcct cgtccagatg cgggttgagc cgcgcgggat
    12121 acggcatgta gaagtgcggg agttcgaacg gctgcgtcat ggcggggggc tacccgccgg
    12181 gcaatcgggt catccgccac gactgggatg atcacaccat cgcgtgaacc cctgccgaaa
    12241 ccgggaactc tcgccgcccg gtgtggcgtt ggccgtcacg gccacacccc tgcccatggc
    12301 ctctttccgg ccctgccgac gacatccgga cagcccggca ccaaaggccg tcactcccct
    12361 tgtccgtcct ccgggccggg gccacggtat ggcccatgat cccctccccg cctccccagc
    12421 accgattacc gcacgccccc gccccggtgt cctggcagga cgagcccggc acggcggacc
    12481 gaccgcccgg ccccgggttc tgggcggtca cccggcacgc cgacgccctc cgcgtcctcg
    12541 aggacccggt gacgtactcc tccctcccgg gacccggcga actccccctc gtgagacggc
    12601 tgctgtccgg ccaggacccg ccccagcaca cccgtctcag agaccacgcg gcccgcgccc
    12661 tcacccccgg acgcgtcgga cgcttcacgg cgaccgcccg agagcgcgcc cgcaccctgc
    12721 tcacccgcgc actggacgcg gcccgcgcca ccgacggcgt cctcgacctc gccaccgccg
    12781 tctccgaccc gtacaccgcg ctcaacctgg ccgacctgct gggcgtcccg cacgccgacc
    12841 ggcgccgtct gcccggccgg accgggccgc atacgctcga cgacacgacc ggctacgccc
    12901 gccggctcgt cgtccaccgc cgccgctatc cggacgacga cctcaccacg gtgctggccc
    12961 acaacgcccg gctcacctcc gacgagctgg acatgctcgt cgccctcctc ctgaccaccg
    13021 gcctcgcccc catgcgcgac gcggcggcgg gcggactcgc ggtgttggcc cggcatcccg
    13081 aggcgtaccg gggcttgcgt gaaggaacag cggaactcga ccccgccatc gaggagttgc
    13141 tccgcctgca cccgcccctg cgcaccctca gccgcaccgc cgcgacggac accgatctct
    13201 ccggccgccg cgtccggcgc ggtgacaggg tcgtcgtctc cctggtcgcc gccaaccgcg
    13261 acgccgaggt cttcgccgcc cccgaccgcc tggacctcgc ccgctcgccc aacccgcacc
    13321 tctccctcgg cgcggggccg cacctctgtc tgggcgccga cttcgcccgg ctgcaactgc
    13381 gcgtcctcca cgaggaggtg ctgtgcgccc tgccggtcct gcggctcgcc gggccggtgc
    13441 tgccgtccgg ctccggcgtc accaacggtg tcgcgtcact gcccgtccgg gccggctgac
    13501 gggttgacct ggatcatcgc gtgagtgccg ctggtgagcc acttccttcc ctccgccttc
    13561 tccagcgcgg cctcggtgga cgcggagagc ccggtgacga cctcggactt gagggtgcgc
    13621 agcgcggcca cggggccggg gaagtaggcg gtcacctcgt cgaagggcgt ggtggcgggc
    13681 cagtaccggt cacccaccag gcggcggtag ttgaggtcgc ccttgaagag ggtgaggtcg
    13741 gccgccgcga agtcggcgcg gaggtcgtcc ggcatgtcgg tgtagggcag cggcgcacag
    13801 gagaagggat gggcgcgcag gacgagccgc ccgtcgccaa gggccgacca gagcgtgtcc
    13861 ccgtactccc ccgccagacc gcccgccgag cggagccggt gcagggcgtc gatcacgtcg
    13921 gcggtggtgg cgtcggagac gtagtacggg gtcggcttga ggtgcaggac cgcgtggccg
    13981 atgcggggct cggtgaggag cgcggcgatg agcagcaggt cggggacgag ctcgcggccc
    14041 gcgttgtccg cgaccaggca gagggtgccg gtgccgccgg ccgggagcag cgaccagagg
    14101 aggtcgctgt cgtcggccac caggccgggg gccgcttcgc gtcgctcgcc gccctccgag
    14161 gacagctgga agctgaggtc ggcgcggttg ccccagaggg agccgctcag cagggcgcgg
    14221 tcgcggtcgc cggccgggcg gtcccgtagt ccgtcgagtg cggacagctc ggcgtcggtc
    14281 tcggcggagt cgagttcgcc ggttttggag gggcggaacg ggtcgacgcc ccgccaggca
    14341 ccggggccga agtagccgac ggcgccgagc agacggcggt agaagtagct ctcggcccac
    14401 agccacggca cgtcgaacca ggatcggccc gcgtaggtgt ccatgcccca gctctgccag
    14461 cgctcgcggt cgggggcgtc ggcggggagg ggttcgatga caccctcggt gcagttcttc
    14521 agcagggcgt ccagcgcgcg ctgctgcggg ggttcgtagg gaaggccggc gcggacctgg
    14581 cggatgatcg ccgggtgccg ttcggccagt gtgcggtgcg ggaaggagcc gggtgcgtcg
    14641 gcgcggatga cgggcgcggt gggggcggcg tcggacatgc cgtcaccgta ccccgcaggt
    14701 cagccggtcc tggcctcccg ctccagttgt gccgcgaggg cgaggtagcg ggggcggcgg
    14761 tgcaccggga ccaggctgcg gagcatcagg taccacatct cggcgacccg gcggggcagc
    14821 cgcgcgggcg gttccagggt gcgcccggcg acccgggtgc cgacgaagaa acagaccagg
    14881 gagtgcgcga cgaccccggc gtccagttcg gcgtgcacat cgcagtcccg gaccgcgccg
    14941 tgcagcttgc gggaggcgaa ctccagccac tccgtgaagg ggtggcgcag cggcggccgc
    15001 atgggcaggt tggtggtgac caggcggagc ccggcacggg gcaccgggtc gtgcacggcg
    15061 aggcgggcga gggcgaaggt ggcccgcatc agcgcctcca gagacgagca gccccggctc
    15121 tcgacctcgg acaccacctg tcgggcggcc accgactgga gttcgaggat ggcgtgggcc
    15181 aggtcctcct tggcggcgaa gtggaagtac agggcgccct tggtgacgtt cgcatgtccg
    15241 acgatgtcgc tcaggctggt ggattcatac ccttgccggt cgaacaggtc ggccgccgcc
    15301 gtgatgatcg tcgtccgggt ctgttcagcg cgcaactgcc tcaccatcgg ccgacccctc
    15361 tcctgcacga acgggacacg cggtttgttt tgacccctcg catacgataa ctcaccgagc
    15421 cgcgacggga gtcacgcggg acacaccgag attccgcgct cttccacact tcctcccctg
    15481 ctcgaccggg gtgaactggg ccttccgctt ttatccggct ccgggggctt ccgggtgcgc
    15541 tgcgtcgctt acgcgaagat tcccgggcgg tgaggggtgc ggcaaaaaca gccgatgcgg
    15601 tctgtgaatt gacttcttca gtcgtccggg gttctgaaca cctcagtgct gtcactcgta
    15661 ttggggacgt ggacgaccat gggcgtggac gccgccgacg acgagcgggg cccggccgaa
    15721 aagggggtcg tggtcgtccg tgcccgacgg cccgtccagg agagcatatg gacgcttggg
    15781 cggcagggcc tgtcgccggc gtgcctggac gcgtatgggg gcgtccaggc acgtatcgag
    15841 agaaccggcg atcagacgag cgtgtgcagg tgcaccgtgc cgtccggcag gcccgtcgac
    15901 tggaccgcga agatgtcagt gttggcgtcg atcttcgtcg ccgctgcctg ccaggttccg
    15961 gcagcgctgt acgagcggtc ccacacgccc gagcccggga cgaccgcgtc ggcggtcatg
    16021 cggccgtcgg gcagcacggc gagggccacc gcggtgatgt cgccgttggt gtcgaggtgg
    16081 gaggagctct gccaggtgcc cgcggcggta cggacgcggt cccagatgcc ggagccgggc
    16141 accacggcct ccaggtgctg ggtgccgttg ggcagcgcgg ccgtggccag gtcggtgatg
    16201 tcgccgttgc tgtcgatctg cgtggcagag gtctgccagg tgcccgaggc gccacgcacc
    16261 cgctcccaca cgcccgagcc gggcacgagg gactccaggt gcagggtgcc gtcggtcaga
    16321 cccgcggcgg cgatccgggt gatggacgtg ttgtcgtcga ccttcgtggc cgtcgtccag
    16381 gtgccgtcgg tgttgcgggt gcggtcccac acgccggagt tcttcaccat cacctcgacg
    16441 tggatcgtgc cgtccttcag cgcggcggcc gtcacggcgg tgatgttgtc gttgtcgtca
    16501 atcttgacgg cgctcgtcgc ccacacgccc gaggcgctgc gcacccgctc ccagacgccg
    16561 gaacccggga ccaccgtgaa ggtgtgcagg gtgccatcgg gcagcgcggc cgaggcgacg
    16621 gcggtgatgg cgtcgttgtc gtcgacctcg ctcgcgctgc cggcccaggt gcccgaggag
    16681 ccgcgggtgc ggtcccagac ggtgccgtgc gggacggtgg acgtggccgg ggcgacgtcg
    16741 agatagtcgg agtcgatgtt gatcgagatg ccgccgtatg tctcggtgtg accgccgctg
    16801 tactggtgga cgcgctggtg gttcgcccag agcgtggacg acacggccgg gtcggcggtg
    16861 tcggcgttgc cgttccacag cgcgtcgtag atgacgtcgg gcatctggta gccgctgccg
    16921 tagtggtcgg cgaggtcgga tatgccggag gtggaactgc tgtacacggc ggacttgtag
    16981 ccctgggcgt ggagttcctt ggtccaggcg gagaggaagc tcagcacgct ggacgaagag
    17041 gaggggctgt aggcctccat gtcgtagtag aggaccgagc ccgcggggaa cccgagcgag
    17101 gatgcctggg tgatggcgtc gtcggcggcg ctcgtgccct gggaggtcgg tgagctgatg
    17161 ccgctcgcct gcacgccgac gtagatgggg aggaagtgcc atccggcgga agcctgttgg
    17221 gagacccatg aggcggtgag gttgggctgg ctgcagcctc ggtaggctcc gccgatgtag
    17281 atgccgacgg cgccgtacgg ggacgcgctg ttccaggtgt tcatggtgct cgccgagggc
    17341 gcggcgcagg cgtcgaaacc cttgccggtg tagtgggtgg tggcgctgga gaccgtggtc
    17401 gcggcgagtg tggagggcgt cagccggcct gtgggtgccg ctcggcgcgc gggagcggcg
    17461 gcctggggcg tgaggtccgc gtccgtggcg atgtcctcga tgagcccggg gttgctcttg
    17521 taggtgccgg tgagctgtat ccgggcgtcg gaggcggcca gctggtgggc ggtcctgtcg
    17581 gtgcgcgcct ggccggcgcc ccgggacccg gccggctgga cgagcagcgc ctcagtgcgg
    17641 ccgacgacgt gagcggggca gttttggtcc gccgaggggg tgccgtagta gagggtgtga
    17701 cggtcgaagc gcacacaggc gtgcggggcg cggtcgaggt cgaccgtgtt ccagccggcc
    17761 ggcacggtga agtggtgacc ccggtaggtg acatggcggg ccggggactt cgccgcctcg
    17821 gtcgcgtggg cggccgggag ggccacgccg gtgagcacgg ccgcggtggc ggtggccgta
    17881 agggatatgc gtatcgctct gcgcagggct gcgggtacgg gcacgggaac tctcctcatt
    17941 ccatgatggg ggtgcacatg acaagcaagg ggacgtgcga acggtgcgtc agcgggtcac
    18001 ggctgccacc agcgggcctt gtagatgccg ccgtcggcga gcgcgtacgg gctggctgtg
    18061 ccggaggcgt cgcggacgta gcgggtcagc cagttcgggc tcaggtctcc gtccggcttg
    18121 gtgaagagga cggtgccgcc ggagttgctg acggccttga caccgcccca cggaccgcgg
    18181 ccgcaggcgg tgcttccgta cggcgtgaag gtgcgggccg acttggagta ctggtagagc
    18241 gccgatcccg tggacaccca cagcaggtcg gacgaccccg ccacggcacc cacgtcgtga
    18301 ccgtcggacg tgggcagttg cacggagagc gaggtcttct cggcgaggac gggctgcgcc
    18361 ggggtgccgg cgacggtgta cgcggcgagc ttgctgccgc ccaccgccca cagcacgttc
    18421 gcgccggagt cccagtggac gccgtgcgcc gtggtgagcg gggtggtgaa gtagtcggtc
    18481 gcggtgggac cttgggacgc ggcgtagacc cggacggcgt tgccgttact gcacgcgaca
    18541 gccacattgc cgtccgggag cagttcgatg ctgtgcgggt tgagatcgtc acccggtcct
    18601 gagccggcga ccagaccggc ccaacggcgt tcgccggtcg ggtactccac cacggcggcg
    18661 aagccgtacg aggcagtgac gagcacgagc gtggatccgc ccgaggtacg cgccttggcc
    18721 tcactgacgt aggtgaagct ggaggccggc tggaggtccg cgtaccggga gtcgccgtcc
    18781 ggggtgaacg accactgcac caccgacgga tcggccgccg ggtcccagtt ggtcttcgtc
    18841 gagtcgagca gcagcacctt gcgcgccttc tggtcgccga cgagaaccgg gggcgcggcg
    18901 gcggcccggg cgttgccgcc gagcggcagc gcgatcccca gggcggcccc caggccgccg
    18961 agcaggagcg agcgccggga gtgcgaacgg gaggacgagg cggaaggcga cgtggaggat
    19021 ctcatgttcg cgcccctcac tgccagatca tgtcgcgggg ggtcaccgcg gtgccgaccg
    19081 gcagctcgac cgtggcagcg gccgggcgct ccttggcggc gacggcggtg agagcgacgg
    19141 acgacgcgtg gacggtgtgg acgccgacgg cggcagtgag gccgagggcg agggtcgcga
    19201 ccgcggcggc gacgggacgg aatgcgggca tggcggaact accttccgga tgagggacgt
    19261 ggggagcgcg agccgtacga agttcgtgga gcggccgcct cagacacgtc ccgcggtgac
    19321 gcgtcctgcg acctggaact aatgtccgcc ctggtcagaa ccttcggaag gggcttcgtc
    19381 cggccacaag aggccgtgtc ccaaaggggc cagcaggggc acttcggctc gcagcagcga
    19441 ccagccggcg aactcagggg ccgcggccag cgcccgcagg cacagggcgg acgccgtccg
    19501 ctcggcctcg cgcagcgaca ggccgcgcag ccacagcccg accaccgggc tgggctcgac
    19561 gcccgggtga acgctgacgt gctccaggcg atcctcgggg ccggcgacgg cacgcagcag
    19621 gcccggggcc tccggcgaca gggggatgcc cctttcgggc gggcacagtc gggcgtgaac
    19681 gagatacata ccggtcaaca ctcacgacaa ggcgctgacg gaagcaacgt gccgagcctg
    19741 gacggttgta ccggaggccg gaaaaggcca caccgcgccg cagccgtaac acagtcgact
    19801 gtgccatgcg atgatcccac gaagatcatt cagtgcccat tgctgaccgt ggggggaagc
    19861 atgttgaccg cgttggggct cgatccggtc gcagaagcgg tctaccgggc catgctcgcc
    19921 gagcgcgccg atggcgtcgc cgagctggcg gggcgcctgg agcttgccga ggacgacgtg
    19981 cgccgggcgc tcgaccagct cagtgaactc tccctggtcc gcgcctccta cacgatgccc
    20041 ggctccctgc acgccgtcag ccctgaggtc ggcctggagc tactgctggc ccgccagcag
    20101 gcggagctcg ccgcccagca gcagcgtgtg gcgacttccc gggcgacggc cgcgcagttg
    20161 atcgccgagc acgccgcact gcgccccttc gccgcccccg gtgtggagca gctcaccggc
    20221 atcgacgaga tccgcgaccg gctggcccgg ctcactcgtc aagtagccgc agaggtcatg
    20281 acgctcgccc cggacggtga gcacacgcct cagtccatcg cggcggcccg gccgctgaac
    20341 aactcgctgc tggagcgcgg cgtgcggttg cgcaccgtct acctcgagag cgtcagcaac
    20401 agtccccaca cccaggagta cctcgaatgg ctgagcgggc gcggcggtga gatccgtacc
    20461 gcggcgacgc tgcccacccg actgatcatc gtcgaccgca ggcatgcggt catcccgctc
    20521 agcagcgatg actccgcggc cggcgcggtg gtgctcagcg gccagggcac actgaccgcg
    20581 ctgtgcgcgc tgttcgacag gatctggcag tccgccaagc ctctcggtga gaacggccgg
    20641 cgcggcccga agggcctcac ggacatcgag gaggccgcgc tcaagctgct ggccgacggc
    20701 catacggacg aggcgatcgc caaacgcctc ggcgtctcgc cccgcaccgc ccgccggatc
    20761 gcgaccggtc tcatgcaacg cctggacgcg cgcagccgtt tcgaggcggg ggcacgcgcg
    20821 gcccagcgcg gctggctcgg gtgagctgag gccgacccgc cacggtctct ccagccttcc
    20881 gctcgggctc gtcccgcctc tcccccgccc ggcccctcaa cggaccggtt cccctggaac
    20941 cgctcctctc cgccgggccg cttccctccc gcgcagccct ctccccgctc cggctctccg
    21001 tcgcatccgg ctcgcgcccg gtccccctcc tccacgctca cggccgaaac cgtccatgga
    21061 cgcatctgtc caggccaaac ccctgtcgtt gacgcgcgca tgacggccag tctcttcacg
    21121 gcgctccgca gcgaagacct gaaaccgcgg accgctccgt cgaccggccc cgctcctgcg
    21181 gcacgccggt gacgcgtgcc cgtcgcaggt cctcctgccg ggctcccgct gccagcgaag
    21241 gagatccgtc atgctcagcc gcgcccgagg ccgtgtccgt gtcgtcgccc ttgccgcagt
    21301 gccgctcgcc gcggcggcgg ctgtgggcgc cgtccgatac gccgccgatc ccgcgccctc
    21361 cgccgcgaag gtgcccgtcg ccacggcggc tccggtcgcc gcggagtcga cgggcccgga
    21421 ggactggacg accgacaccg cgcccggcag tgcgcccacc gctccgtccc acagcgcgtc
    21481 cgcctcccgc tccccgtccc actccccatc ccactccccg tccgcgtcac gctccccgtc
    21541 cgggcccgcg gccggcgccg cccccgccgt gcacgcgctg cccgcggcga agctgcccga
    21601 cgcgcaccgc tccgcctgga aggcgatcgg tccgccccgg acccggcaga ccacccacga
    21661 cgtgaacgtc agcgagtgcg gctcggtcca cggggcagtc ggctggcggc agcagggcta
    21721 cgccagcaag gcgaacaccc cagccatcca ggacacgttc accttcacct ccgcctcggc
    21781 cgccgacgcc gcctaccgca cgctgctcac cgccttcgac ggctgcgggc acaacctgcg
    21841 cgccttccag gcacagcacg gcacgcccca ggacgcggtg gtcacgaaga ccgcgtccat
    21901 caccgacggc accgcctact cacgctcctg gaccgccgtg gccggcatct ccatgcccgg
    21961 ccggcagacc aaccactact acgtcgtcag gcgcggggcg ctcctgacgg tcgtgcagta
    22021 cacccagccg ggcgtcgtca ccacggccga cccgaaccac caggactccg gcgaccgggc
    22081 ggacctgtcc accatcgccg agcacatgta accgcgacac cacccctgtc tctctcacgg
    22141 aagacgaatt caccatgccg
//
