LOCUS       NZ_SHKU01000002        21083 bp    DNA     linear   CON 27-MAY-2024
DEFINITION  Streptomyces sp. BK022 Ga0307664_102, whole genome shotgun sequence.
ACCESSION   NZ_SHKU01000002
VERSION     NZ_SHKU01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. BK022
  ORGANISM  Streptomyces sp. BK022
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1192486)
  AUTHORS   Kalluri,U.
  TITLE     Understanding the reciprocal impacts of modified plant cell wall and
            associated microbiome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1192486)
  AUTHORS   Kalluri,U., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 215.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004217355.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 02:58:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,482
            CDSs (total)                      :: 6,401
            Genes (coding)                    :: 6,280
            CDSs (with protein)               :: 6,280
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 49 of 121
            Pseudo Genes (incomplete)         :: 92 of 121
            Pseudo Genes (internal stop)      :: 16 of 121
            Pseudo Genes (multiple problems)  :: 29 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:05:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 686671
            Orig. end                         :: 707754
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SHKU01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21083
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21083
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21083
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11083](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11083
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(301..1617)
                     /gene="aroA"
                     /locus_tag="EV284_RS09260"
                     /old_locus_tag="EV284_1853"
     CDS             complement(301..1617)
                     /EC_number="2.5.1.19"
                     /GO_function="GO:0003866 - 3-phosphoshikimate
                     1-carboxyvinyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="aroA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018571327.1"
                     /locus_tag="EV284_RS09260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1853"
                     /product="3-phosphoshikimate 1-carboxyvinyltransferase"
                     /protein_id="WP_130332169.1"
                     /transl_table=11
                     /translation="MTVNPAHTALWPAPHATGAVDATVHVPGSKSVTNRALVLAALASE
                     PGWLRRPLRSRDTLLMAGALRAMGVEIEEGVGPDGSGEAWRVLPTGLRGPATVDVGNAG
                     TVMRFLPPVAALADGPVRFDGDPRSYERPLHGVIDALRVLGARIDDDGRGALPLTVHGG
                     GALEGGPVAVDASSSSQFVSALLLSAPRFNQGVEVRHTGATLPSLPHIRMTVDMLRAVG
                     AQVDTPESGGEPNVWRVTPGALLGRDLTVEPDLSNAQPFLAAALVTGGKVTIPDWPERT
                     TQPGDRLREIFTEMGGSCELTEYGLVFSGSGAVHGIDVDLGDVGELTPGIAAVAALADS
                     PSTLRGVAHLRLHETDRLAALTKEINELGGDVTETADGLHIRPRPLHGGVFHTYDDHRM
                     ATAGAIIGLAVPGVRIENVATTAKTLPDFPELWAGMLGN"
     misc_feature    complement(1635..1649)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.58"
                     /tool="antismash"
     misc_feature    1636..1650
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            complement(1679..2401)
                     /locus_tag="EV284_RS09265"
                     /old_locus_tag="EV284_1854"
     CDS             complement(1679..2401)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016437900.1"
                     /locus_tag="EV284_RS09265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1854"
                     /product="M50 family metallopeptidase"
                     /protein_id="WP_130332171.1"
                     /transl_table=11
                     /translation="MDSNTTTALPDLWGRLSGTQPGPDLWVVLATLAAALAVVAPHPVW
                     RVARNAITIAHEGGHGLIALVTGRKLTGIRLHSDTSGLTVSRGKPYGLGMILTAAAGYT
                     APSLLGLGGAALLAAGRITLLLWVATALLLAMLVMIRNAYGALTVVLTGGAFLLVSWLA
                     GPQVQAAFAYAVVWFLLLGGVRPPFELQAKRRRGGAGDSDADQLSRLTHVPAGLWLFLF
                     HAVSLCSLMGGGQWLLRL"
     gene            2452..3306
                     /locus_tag="EV284_RS09270"
                     /old_locus_tag="EV284_1855"
     CDS             2452..3306
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="EV284_RS09270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1855"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_130332173.1"
                     /transl_table=11
                     /translation="MCGRYAASRSPEDLAGVFDIEVGVPPAPAEGGDRTPEPEETLAPD
                     WNVAPTKEVYAVLDRPLKDAADRRPVRQLRQLKWGLVPSWAKTPEGAARMINARAETVH
                     EKPAYRRAFAARRCILPADGYYEWVTGEQERDLEVEGKKKRARKQPYFVTPADGSVFAM
                     AGLYEFWRDGTLPDDHPGAWWATCSVITTEAEQGPLAVAPAEGPGSLAEIHPRMPLMLT
                     PDRWDAWLDPARTDPGELRELLAPPPGGLMRAYPVSTAVSNVRNNGPELLKELEGPEEG
                     TLF"
     gene            3329..3955
                     /locus_tag="EV284_RS09275"
                     /old_locus_tag="EV284_1856"
     CDS             3329..3955
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="EV284_RS09275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1856"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_130332991.1"
                     /transl_table=11
                     /translation="MTETVETEAGTARVTWHHAPEPRLVLALGHGAGGGVEARDLQALA
                     AALPAQGVSVALVEQPWRVAGRKVAPAPKTLDTGWRGLWPALTRPGLPVISGGRSAGAR
                     VACRTAAGLGARAVLALSFPLHPPGKPEKSRADELLGAGVPTLVVQGGNDPFGRPEEFP
                     EGGFELVEVACGDHSFAVAKRAPVTPEAALEAVTDAVTRWAASLG"
     misc_feature    4055..4070
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.78"
                     /tool="antismash"
     gene            4214..4909
                     /gene="sigR"
                     /locus_tag="EV284_RS09280"
                     /old_locus_tag="EV284_1857"
     CDS             4214..4909
                     /codon_start=1
                     /gene="sigR"
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="EV284_RS09280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1857"
                     /product="RNA polymerase sigma factor SigR"
                     /protein_id="WP_030807427.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGAGSGQAEQPEGQGVSAGTGAESSTERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKSALQSIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGE
                     SNEAKGSGS"
     gene            4906..5208
                     /gene="rsrA"
                     /locus_tag="EV284_RS09285"
                     /old_locus_tag="EV284_1858"
     CDS             4906..5208
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019522887.1"
                     /locus_tag="EV284_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1858"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_030807430.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFQHHFEECHPCL
                     EKYGLEQAVKKLVKRCCGHDDVPADLRAKVMGRIELIRSGGTVPEHDVTAAARES"
     gene            5316..6626
                     /locus_tag="EV284_RS09290"
                     /old_locus_tag="EV284_1859"
     CDS             5316..6626
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674892.1"
                     /locus_tag="EV284_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1859"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_130332177.1"
                     /transl_table=11
                     /translation="MEAVPARARVCVAGAALLAALCALPALTGPTAWGTLGLLAALYAL
                     CDQVVRRRFGGTFYPVLLAGAFLLTPAAAALVPLPAALLSPVEHAHALPRRVWRAARPA
                     LAVWAAARTHHALDGGAAVEGPVFPYALLPAGAAVLAFCLVLTLLDGAMHAAADRVPPR
                     RAWRGLFTRSLAPVAVHGLAGLMTAVLWRSPYGPVAALLVLLPMGVSCWVFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGQASVMIARQLGLDDERVEVLRFAGILHDVGK
                     LGVPTRLLRKDGPLTPEERRIIELHPEYGHEMTRGIAFLGEARAAILHHHERLDGSGYP
                     YGLAGTQIPECARVVAVADAFDAMTSTRSYSRARPVEVAVAELERCAGAQFDPRMVGAL
                     AAALRRHGWRPEVTADEPAPGVPPRQRTHGRTTGAHR"
     gene            6623..7852
                     /locus_tag="EV284_RS09295"
                     /old_locus_tag="EV284_1860"
     CDS             6623..7852
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544418.1"
                     /locus_tag="EV284_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1860"
                     /product="metal-dependent phosphohydrolase"
                     /protein_id="WP_130332179.1"
                     /transl_table=11
                     /translation="MTARRLIHGAAALLAAVAFGATLWTGVDDRGTALAFGVLIAVGEL
                     TRWKGGGSRRAAPLGTAGSLSYALLGADAGHPARHGAGQILTVVVVATLLGGVPHIWRG
                     SSPTLDHLARRVLTVGFAAVCFQPLYSRGVFEQWDGSAYALLLVALLVLTALCDAVLAA
                     ALARSRTGWPFGPLLREELRGLLGIGSAVCATGAVMALAVAVAGLWALPVFCLPLLLTQ
                     LSLRRYAAVRATYRQTITSLARATEIAGYTPAGHARRVAALSLAVGRDLGLTGTELTVL
                     EHAALMHDIGQLSLVDPVPAGATAGLPGEEQRRIALLGGAVVRQTGVAAAVAVVVERQA
                     DPYRDQPVAARIVRAVNAYEEKSRDAGVEGPLRALEELRLATAGDYAPEVVESLARVLS
                     RDCLTLPVAG"
     gene            7963..8943
                     /locus_tag="EV284_RS09300"
                     /old_locus_tag="EV284_1861"
     CDS             7963..8943
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="EV284_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1861"
                     /product="hypothetical protein"
                     /protein_id="WP_030807439.1"
                     /transl_table=11
                     /translation="MRIFGKVRNRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWLAESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGGATALGEPLGMELGSAAVRLSPEGEAEVVWGRRLDPARIEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSTGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGIAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9095..9745
                     /gene="def"
                     /locus_tag="EV284_RS09305"
                     /old_locus_tag="EV284_1862"
     CDS             9095..9745
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="EV284_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1862"
                     /product="peptide deformylase"
                     /protein_id="WP_130332181.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVVDTEDCEERETGWRERGTSRPIT
                     VVGNPVLHKECADVTEFGPELEQLVADMFASQRTAEGVGLAANQIGVSRKVFVYDCPDD
                     DGVRHTGVVVNPKLVELPAAARRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPI
                     KVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRRDALRQMAENEPRYDVVAND"
     gene            10001..11083
                     /gene="cyc1"
                     /locus_tag="EV284_RS09310"
                     /old_locus_tag="EV284_1863"
     CDS             10001..11083
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="EV284_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1863"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_130332183.1"
                     /sec_met_domain="T1TS (E-value: 4.8e-62, bitscore: 206.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFSSGATSATAVAVPPSLALPVIEDAFPRRLHPYWPRLQENTR
                     RWLLEKRLMSPDKVREYADDLCYTDLMAGYYLGAPDDVLQAIADYSAWFFVWDDRHDRD
                     IVHGRTEDWGRLRRRLHTALDAPEDHLHHEDALVAAFADSVLRLYAFLPAAWNQRFARH
                     FHEVIEAYDREFDNRVAGRVPGVEEYLALRRLTFAHWIWTDLLEPSAGCQLPDSVRKNP
                     AFRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHSGLTLEEAVEELRRRIEN
                     CIAEFVEAEREAMEFAGELDDGTVRGKELSTAVRTCVGNMRNWFSTVYWFHHESGRYMV
                     DTWEDRSTPPYVNNEAAGEK"
     gene            11080..12450
                     /locus_tag="EV284_RS09315"
                     /old_locus_tag="EV284_1864"
     CDS             11080..12450
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544422.1"
                     /locus_tag="EV284_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1864"
                     /product="cytochrome P450"
                     /protein_id="WP_130332185.1"
                     /sec_met_domain="p450 (E-value: 3.4e-66, bitscore: 219.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDAVNPETREVADLKDPPLAGGAVPVLGHGLKLARDPLAFMTQ
                     LRDHGEVVRLKLGPKTVYAVTAPALTGALALSPDYKIDGPVWESLEGLLGKQGVATANG
                     PLHRRQRRTIQPAFRLAAIPAYGPIMEEEAHALTERWRPGVPVDATSESFRVAVRIAAR
                     CLLRGQYMDERAERLSTDLATVFRGMYRRMVLPLGPLYRLPFPSNLEFNRALADLHLLV
                     DEIVTERRASGQKPDDLLTALLEAKDDNGDPISEQEIHDQVVAILTPGSETIASTIMWL
                     LQILADHPGHAEKVRAEVESVTGGAPVGFEHVRRLSHTNNVVVEALRLRPAVWILTRRA
                     LTDTALGAYRIPAGADIIYSPYAIQRDARSYARHLDFDPDRWLPERAEEVPKYAMSPFS
                     VGNRKCPSDHFSMAQLSLIVAAISAKYRFRQVEDSDATTRVGITLRPHRLLVEPMEW"
     gene            complement(12479..13441)
                     /locus_tag="EV284_RS09320"
                     /old_locus_tag="EV284_1865"
     CDS             complement(12479..13441)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544423.1"
                     /locus_tag="EV284_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1865"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_130332187.1"
                     /transl_table=11
                     /translation="MLKNVVAVLLDGVHPFELGVVCEVFGIDRSDDGLPVYDFAVASAE
                     GPTLRTHCGFTVSTPHGLERLEEADLIAVPAGESYTSRDYPPALLDALRRAVARGARVL
                     SVCTGVFVLAEAGLLDGRRCAVHWHNAEELSRRHPRLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANKIARRMVVPPHRDGGQAQYIERPLPKAPCDTVGEVLVWME
                     EHLDQEVTVEQLAARAHMSPRTFARRFQQETGTTPYRWILRQRVLLAQRLLEGTDETVD
                     SIAWRTGFGNAAALRHQFVRALGTTPNAYRRAFRGPQAA"
     gene            13534..13782
                     /locus_tag="EV284_RS09325"
                     /old_locus_tag="EV284_1866"
     CDS             13534..13782
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047586.1"
                     /locus_tag="EV284_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1866"
                     /product="hypothetical protein"
                     /protein_id="WP_130332189.1"
                     /transl_table=11
                     /translation="MNGNQIEGLIGMAATLGILVLLVLPSVIGIVRERRVDRQLGQAQK
                     DRGQETATAQKSSSRSTVPSTATWYADGRRSKKFVSS"
     gene            complement(13695..14702)
                     /locus_tag="EV284_RS09330"
                     /old_locus_tag="EV284_1867"
     CDS             complement(13695..14702)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="EV284_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1867"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_130332191.1"
                     /transl_table=11
                     /translation="MTEKNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLHSD
                     VADLAKLSPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEEAV
                     HVQFYLTLLDTYLPDPEDRTAAFAAVENIPSIREKAEFCFKWIDSVDKLDRLETKADRR
                     KFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFDVV
                     DTVRKEEPELFDDQLEQQVKDMLREAVEAELQFARDLCGDGLPGMNTESMRQYLECVAD
                     QRLTRLGFAPEYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(14702..17083)
                     /locus_tag="EV284_RS09335"
                     /old_locus_tag="EV284_1868"
     CDS             complement(14702..17083)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="EV284_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1868"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_130332193.1"
                     /transl_table=11
                     /translation="MTIAPADPASATPATEAPVENDGPGAALLRTLTQLTADLPDADPG
                     RVAAAALRGRSARADEAELRELATEAAAGLISEDPAYSRLAARLLTLSIRAEAASQGVT
                     RFTESVAVGHREGLVADRTADFVALHAARLDALIDTGADDRFGYFGLRTLYSRYLLRHP
                     ITRKVIETPQHFMLRVASGLAENDSVPAVDEVAALYGLMSRLDYLPSSPTLFNSGTRHP
                     QMSSCYLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGI
                     VPFLKTLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAH
                     WVPDEFMRRVNADESWSLFSPADVPELVDLWGPEFDAAYRKAEEAGLARKSMPARELYG
                     RMMRTLAQTGNGWMTFKDAANRTANQTALPGNVVHSSNLCTEILEVTDDGETAVCNLGS
                     VNLGAFVADGDIDWERLDETVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGL
                     QDVFFKLRIPFDSPEAKALSTRIAERIMLASYEASADLAERNGPLPAWEQTRTARGVLH
                     PDHYDVELTWPERWAALRARIAEVGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFK
                     RETLSGEFLQVNAYLVQELKNLGVWDARTREELREANGSVQGFAWIPEDVRNLYRTAWE
                     IPQRGLIDMAAARTPFLDQAQSLNLFLETPTIGKLSSMYSYAWKSGLKTTYYLRSRPAT
                     RIARAAGRAQETKTIPVQQAADPDAVACSLENPESCEACQ"
     regulatory      complement(17230..17309)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17331..17345)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(17362..17376)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(17515..19125)
                     /locus_tag="EV284_RS09340"
                     /old_locus_tag="EV284_1869"
     CDS             complement(17515..19125)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007444565.1"
                     /locus_tag="EV284_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1869"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_130332195.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFVFFFLAVTVLGFLASRWRKAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHRHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     EDTNWFVKDLPLLIAFGVLAAYTYSSGLRAPAMIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDEIFAKAGEKYAAAGAGGVVPAPAGQWTYATLALGSALALFMYPHSITATLSSKSRDV
                     IRRNTTILPLYSLMLGLLALLGFMAIAAGVKVTNGQLAIPQLFEDMFPDWFAGVAFAAI
                     GIGALVPAAIMSIAAANLFTRNIYKDFIKPDATPEQETKVSKLVSLLVKVGALVFVLTM
                     DKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAVGMVYGTLAAYGVASPT
                     QKHFGGSAKEIPGIGEIGYIGLTSFVLNVVVTVVLTFVLKAVKAPDGIDETTPADYTAD
                     AGDPGVEVELPPATAGSSH"
     gene            complement(19122..19385)
                     /locus_tag="EV284_RS09345"
                     /old_locus_tag="EV284_1870"
     CDS             complement(19122..19385)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973741.1"
                     /locus_tag="EV284_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1870"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_165425491.1"
                     /transl_table=11
                     /translation="MPEDSEVRQPVVTPVRVVIGLCLVAPFVAMLWVGSFSKVDPTFIG
                     IPFFYWYQMLWVLVSTSLTMTAYQLWQRDQRSRKTRSGGVSK"
     gene            complement(19525..20289)
                     /locus_tag="EV284_RS09350"
                     /old_locus_tag="EV284_1871"
     CDS             complement(19525..20289)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="EV284_RS09350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_1871"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_030807463.1"
                     /transl_table=11
                     /translation="MSTDVSRAENEAGATVRTARVPKYYRLKKHLQEMTETLPPGTPVP
                     PERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVAQALQLTSYTEDMRA
                     QGLEPTSQLLDIGYITADDRLAGLLDISAGGRVLRIERLRMANAEPMAIETTHLSAKRF
                     PALRRSLVKYTSLYTALAEVYDVHLAEAEETIETSLATPREASLLGTDVGLPMLLLSRH
                     SVDREGRPVEWVRSVYRGDRYKFVARLRRPQD"
     misc_feature    20422..20437
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.44"
                     /tool="antismash"
     misc_feature    complement(20568..20581)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(20591..20606)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.22"
                     /tool="antismash"
ORIGIN
        1 atgcgaacga tccgcgcgag ggtgtccttc tggcccgaca ggtcaccgac cagcgagacc
       61 cggtcgccca ccacggccgc cttgcggccc agctcgcggg ccttcatggc ggtgatcgtc
      121 cgcccctcga ccaggcaggt cagccggccc cggtcgacgg tgaggaccat gccctccgcc
      181 gcgtcctcgt gcttgggccg gatgttggtc cgcgggcggt tgcccttgcg gttgggacgc
      241 gtgcggatgt cgtcctcgtc ggtgtgcttg ccgtagcggc gcatgatctc gtcccgcccg
      301 tcagttaccg agcatcccgg cccacagctc ggggaagtcc gggagcgtct tcgccgtcgt
      361 cgccacgttc tcgatccgca cccccggcac ggccaggccg atgatcgcgc ccgccgtcgc
      421 catccggtgg tcgtcgtagg tgtggaacac accgccgtgc agcggacgcg ggcggatgtg
      481 caggccgtcg gcggtctcgg tgacgtcgcc gcccagttcg ttgatctcct tggtgagcgc
      541 ggccagccgg tccgtctcgt gcagccggag gtgggccaca ccgcgcaggg tggacgggga
      601 gtcggcgagg gccgcgaccg cggcgatgcc gggggtcagc tcgcccacgt cacccaggtc
      661 cacgtcgata ccgtgcaccg cgccggaacc ggagaacacc aggccgtact cggtcagctc
      721 gcaggagcca cccatctcgg tgaagatctc ccgcagccgg tcacccggct gggtggtgcg
      781 ctccggccag tccgggatcg tcaccttgcc cccggtgacc agggcggccg ccaggaaggg
      841 ctgggcgttg gacaggtccg gctcgaccgt caggtcccgg cccagcagcg cgcccggcgt
      901 cacccgccac acgttcggct cgccgcccga ctccggggtg tcgacctggg cgccgaccgc
      961 gcgcagcatg tccaccgtca tccggatgtg ggggagcgag ggcagcgtcg cgccggtgtg
     1021 gcggacctcc acgccctggt tgaagcgcgg cgcggacagc agcagcgcgg agacgaactg
     1081 ggaggaggag gacgcgtcga ccgccaccgg gccgccctcc agcgccccgc cgccatgcac
     1141 ggtcagcggc agcgcgcccc ggccgtcgtc gtcgatccgg gcacccagga ccctgagcgc
     1201 gtcgatcacg ccgtgcagcg ggcgctcgta ggagcggggg tcgccgtcga agcggaccgg
     1261 cccgtcggcc agcgcggcga ccggcggcag gaagcgcatg accgtgcccg cgttgccgac
     1321 gtccaccgtg gccggaccgc gcagccccgt cggcagcacc cgccacgcct cgccggagcc
     1381 gtccgggccg acgccctcct cgatctcgac gcccatcgcg cgcagcgccc cggccatcag
     1441 cagggtgtcc cgcgaccgca gcggacggcg cagccagccc ggctcggagg cgagggcggc
     1501 cagcaccagg gcccggttgg tgaccgattt ggaaccgggc acgtggaccg tcgcgtcgac
     1561 ggccccggtc gcgtgcgggg cgggccagag ggcggtgtga gcggggttca cggtcatgcg
     1621 ccccacttta gtggctggga ccgcccccag atcttgatcg aacccgccgg gtggcggctc
     1681 agagtcgcag cagccactgc ccgccgccca tcagcgagca cagggacacc gcgtggaaca
     1741 ggaacagcca cagcccggcc ggcacatgcg tgagccggga cagctggtcc gcgtccgagt
     1801 ccccggcgcc gccgcgcctg cgcttggcct gcagctcgaa gggcggacgc actccgccga
     1861 gcagcaggaa ccagaccacc gcgtacgcga acgccgcctg cacctgcggt ccggccagcc
     1921 acgacaccag caggaaggcc ccgccggtca gcaccacggt cagcgccccg taggcgttgc
     1981 ggatcatcac cagcatcgcc agcagcaggg cggtggccac ccacagcagc agggtgatgc
     2041 gcccggcggc cagcagcgcg gccccgccga gcccgagcag cgagggcgcg gtgtagcccg
     2101 ccgcggccgt caggatcatg ccgagcccgt acggcttgcc ccggctgacc gtgaggccgc
     2161 tggtgtcgga gtgcagccgt atgccggtca gcttgcggcc ggtgacgagc gcgatcaggc
     2221 cgtggccgcc ctcgtgcgcg atggtgatcg cgttccgggc cacccgccac accgggtgcg
     2281 gggcgaccac ggcgagcgcg gcggccaggg tggcgaggac cacccacagg tcgggaccgg
     2341 gctgggtgcc gctgagccgg ccccagaggt cgggcagcgc ggtggtcgtg ttgctgtcca
     2401 tgtctgcggg tggctccctg tcgtcggacg gactctggca ctgtggctgg tatgtgcgga
     2461 cggtatgcgg ccagtcgtag cccagaggat ctcgcgggag tcttcgacat cgaggtgggg
     2521 gtcccccctg ccccggcgga agggggcgac cgtaccccgg aacccgagga gaccctggcg
     2581 ccggactgga acgtggcccc gaccaaggag gtctacgcgg tcctggaccg tccgctgaaa
     2641 gacgccgccg accgccgccc ggttcgccag ctgcgccagc tgaagtgggg actggtgccg
     2701 tcctgggcca agacccccga gggcgccgcc cggatgatca acgcccgcgc ggagaccgtg
     2761 cacgagaagc cggcctaccg ccgcgccttc gccgcccgcc gctgcatcct gcccgccgac
     2821 ggctactacg agtgggtcac cggggagcag gagcgcgatc tggaggtcga gggcaagaag
     2881 aagagggccc gcaagcagcc gtacttcgtc acccccgccg acggttcggt gttcgccatg
     2941 gcggggctgt acgagttctg gcgcgacggc accctgcccg acgaccaccc cggcgcctgg
     3001 tgggcgacct gctcggtgat caccaccgag gccgagcagg gccccctggc cgtcgccccc
     3061 gccgagggcc ccggctcgct cgccgagatc cacccccgga tgcccctgat gctgaccccg
     3121 gaccgctggg acgcctggct ggacccggcc cgcaccgacc ccggggagct gcgggagctg
     3181 ctggccccgc cgcccggcgg cctgatgcgg gcctacccgg tgtcgacggc cgtcagcaac
     3241 gtccgcaaca acgggccgga gctgctgaag gagctggagg ggccggagga gggcacactc
     3301 ttctgatgtg agccccactt ctgccgccgt gaccgagacc gtcgagaccg aggccgggac
     3361 cgcgcgcgtc acctggcacc acgcgcccga gccccgcctc gtcctggccc tcggccacgg
     3421 tgccggcggc ggtgtcgagg cccgcgacct ccaggcgctg gccgccgccc ttcccgcgca
     3481 gggggtgagc gtcgccctgg tcgaacagcc ctggcgggtg gccgggcgca aggtcgcccc
     3541 ggcgccgaag accctggaca cgggctggcg gggcctgtgg cccgcgttga cccggcccgg
     3601 cctgccggtg atctccggcg ggcgcagcgc cggcgcccgt gtcgcctgcc gcaccgccgc
     3661 cgggctgggc gcccgcgcgg tgctggcgct gagcttcccg ctgcacccgc cgggcaagcc
     3721 ggagaagtcc cgcgcggacg agctgctcgg tgccggggtg cccacgctcg tcgtccaggg
     3781 cgggaacgac cccttcggcc gccccgagga gttccccgag ggcggcttcg agctggtcga
     3841 ggtggcctgc ggcgaccact ccttcgcggt ggccaagcgg gctcccgtga cgccggaggc
     3901 cgcgctggag gccgtgacgg acgccgtcac caggtgggcc gcgtcactcg ggtgaccctc
     3961 gggaatgccg gacggggcac cgctgttgtg gccagcagaa gtactggagc gccggtgagg
     4021 cgtcgtcgcg ggagaggaag tcagccgcat gggttcgacc gcatgtccga gtcgcagcag
     4081 ccgtactgac ctggactgga cggtgctgca cgcggccaag accgctccga ttcgagcggc
     4141 ggcgggtacg ggtcgtgttc tatcctccga aacgagtggg gccggtttcg gccttgcccg
     4201 tgaacttgag gaggtgggtc cggtcaccgg taccgacgca ggggccggca gcggccaggc
     4261 ggagcagccc gagggccagg gcgtgagcgc gggaacgggc gccgagagca gcacggagcg
     4321 cagcgcgcgc ttcgagcggg acgcgctcga attcctcgac cagatgtact cggccgcgct
     4381 gcgcatgacg cgcaacccgg ccgacgccga ggatctggtg caggagacgt atgccaaggc
     4441 gtacgcctcg ttccaccagt tccgcgaagg caccaacctc aaggcgtggc tgtaccggat
     4501 cctcaccaac accttcatca actcgtaccg caagaagcag cgggaaccgc agcgcagcgc
     4561 ggccgaggag atcgaggact ggcagctcgc gcgcgccgag tcgcacatgt cgaccggcct
     4621 gcgctccgcc gagtcccagg cgctggacca cctcccggac tcggatgtga agtccgcgct
     4681 ccagtcgatc ccggaggagt tccgcatcgc ggtctacctc gcggacgtag agggctttgc
     4741 gtacaaggag atcgcggaca tcatggggac acccatcggt acggtgatgt cccggctgca
     4801 ccggggccgc cgtcaactgc gcggcatgct ggaggactac gcgcgcgagc gcggcctggt
     4861 ccccgcgggc gccggagagt cgaacgaagc gaaaggctcg ggctcatgag ctgcggagag
     4921 ccgcacgaga cggactgcag tgaggtcctc gaccacctgt acgagttcct cgacagcgag
     4981 atgccggacg tcgaccgcga caagttccag caccacttcg aggaatgcca cccgtgcctg
     5041 gagaagtacg gtctggagca ggccgtcaag aagctggtca agcggtgctg cggacatgac
     5101 gacgtccccg ccgacctgcg ggccaaggtc atgggccgga tcgagctgat ccgctccggc
     5161 ggcaccgtcc ccgagcatga cgtgaccgcg gccgcccgcg agagctgacc gcggcttccg
     5221 tcacccgaac gtgctaatcc cgccggaccc gcccccgccc tccccctgac ccgtcctacg
     5281 ctccacccgg acggggcacg gtcggggagg gcgtcatgga ggcggttccg gcaagggcac
     5341 gggtctgcgt ggccggtgcc gccctgctcg ccgccctctg cgcgctgccc gccctcaccg
     5401 gccccacggc ctggggcacc ctcggactcc tcgccgcgct ctacgcgctc tgcgaccagg
     5461 tcgtccgccg ccggttcggc ggcaccttct accccgtcct gctcgccggg gccttcctgc
     5521 tgaccccggc cgccgccgcg ctcgtgccgc tgcccgccgc cctgctctcc ccggtcgagc
     5581 acgcgcacgc cctcccgcgc cgcgtctggc gcgccgcccg gcccgcgctc gccgtgtggg
     5641 ccgccgcccg gacgcaccac gcgctcgacg gcggcgcggc cgtcgagggc cccgtcttcc
     5701 cgtacgcgct gctgcccgcc ggggccgccg tgctcgcctt ctgcctggtg ctcacgctgc
     5761 tcgacggcgc catgcacgcg gccgccgacc gggtcccgcc gcgccgggcc tggcgggggc
     5821 tgttcacccg ctccctcgcc cccgtcgccg tgcacggtct ggccggactg atgaccgccg
     5881 tgctgtggcg cagcccctac gggcccgtcg ccgccctgct ggtgctgctg ccgatgggcg
     5941 tctcctgctg ggtgttcgcc cagtaccacc gcgaacgcgc cgcccaccag gccaccatcc
     6001 gcgccctcgt ccaggccgtc gacatcaagg acgggtacac gagggggcac agcgagcgcg
     6061 tcgggcaggc gtccgtcatg atcgcccgcc agctcggcct ggacgacgaa cgcgtggagg
     6121 tgctgcgctt cgcgggcatc ctgcacgacg tcggcaagct cggcgtcccc acccggctgc
     6181 tgcgcaagga cggcccgctc acccccgagg aacgccggat catcgagctc caccccgagt
     6241 acggccacga gatgacccgt ggcatcgcct tcctcgggga ggcccgcgcg gcgatcctgc
     6301 accaccacga acgcctcgac ggcagcggct acccctacgg gctcgccggc acccagatcc
     6361 ccgagtgcgc ccgggtggtc gccgtcgccg acgccttcga cgcgatgacc tccacccgct
     6421 cctacagccg ggcccgcccg gtcgaggtcg ccgtcgccga actggagcgg tgcgcgggcg
     6481 cccagttcga cccccggatg gtcggcgcgc tcgccgccgc cctgcgccgc cacggctggc
     6541 gccccgaggt cacggccgac gaacccgccc ccggcgtccc gccgcgccag cgcacccacg
     6601 gccgtaccac cggggcccat cggtgaccgc ccgccgcctg atccacggcg ccgccgcact
     6661 cctcgccgcc gtcgcgttcg gcgccaccct gtggaccggc gtcgacgacc ggggcaccgc
     6721 gctcgccttc ggcgtcctca tagccgtcgg cgaactcacc cgctggaagg gcggcggctc
     6781 ccgccgcgcc gcaccgctcg gcaccgcggg ctccctctcg tacgccctgc tcggtgccga
     6841 cgccggacac cccgcccggc acggcgccgg tcagatcctc accgtggtcg tcgtcgccac
     6901 gctgctcggc ggggttccgc acatctggcg cggaagcagc cccaccctgg accacctcgc
     6961 ccgccgcgtc ctcaccgtcg gcttcgccgc cgtctgcttc caacccctct acagccgggg
     7021 cgtgttcgag cagtgggacg gttccgccta cgccctgctg ctggtcgcgc tgctcgtcct
     7081 gaccgcgctg tgcgacgccg tactggccgc cgcgctcgcc cgctcccgca ccggctggcc
     7141 cttcggcccg ctgctgcgcg aggaactgcg cggactgctc ggcatcgggt ccgccgtctg
     7201 cgccaccggc gcggtgatgg cgctcgcggt cgccgtcgcc ggactctggg cgctgccggt
     7261 gttctgtctc cccctgctgc tcacccagtt gtcgctgcgc cggtacgcgg ccgtgcgcgc
     7321 cacctaccgg cagaccatca cctccctggc ccgcgccacc gagatcgccg gatacacccc
     7381 ggccggccac gcccgccggg tcgccgccct cagcctcgcg gtgggccggg acctcgggct
     7441 caccggcacc gagctgaccg tgctggagca cgcggcgctg atgcacgaca tcggccagct
     7501 cagcctggtc gacccggtcc ccgcgggcgc caccgccggg ctgcccggcg aggagcagcg
     7561 ccgtatcgcc ctgctgggcg gggcggtggt ccggcagacc ggggtggccg cggccgtcgc
     7621 cgtggtcgtg gagcggcagg ccgaccccta ccgggaccag ccggtcgccg cccgcatcgt
     7681 gcgcgcggtc aacgcctacg aggagaagtc ccgcgacgcc ggggtggagg gccccttgcg
     7741 cgcactggag gaactgcggc tggccaccgc cggggactac gcccccgagg tggtggaatc
     7801 actggcgcgg gtcctgtccc gcgactgtct gaccctgccg gttgctgggt aaccgatggg
     7861 taatgagcgc ctctcccgag tgacgtggtt ggatgcgagg gagaggcagt ccgggggcag
     7921 gagccagccc actgagcgga acggaactgg caggcgggaa tcgtgaggat cttcggcaag
     7981 gtacggaacc ggccctccgc ctcctggcgg caggccaccg accgggcgtt cacgctcatc
     8041 ggcgacggcc ggtacgagga cgcgggcgaa ctgctgaccc gcgccgccga tctggagccc
     8101 tggctcgccg agtcctggtt caacctggcc ctgctgcaca agttccggca cgactgggag
     8161 caggcccgcg cggccgggct gcgcgcggtc gccctgctgg accgggagac cggcgcgccc
     8221 gactggtgga acgtgggcat cgccgccacc gcgctccagg actggccgct ggcccgccgc
     8281 gcctggcagg cgtacggact gaaggtgccc ggcggtgcca ccgcgctcgg tgagccgctc
     8341 ggcatggagc tgggcagcgc ggccgtccgg ctctcccccg agggcgaggc cgaggtggtc
     8401 tggggacgtc ggctggaccc ggcgcggatc gaggtgctgt ccatcccgtt gccgtcctcg
     8461 gggcggcgct ggggcgaggt cgtgctgcac gacggtgtcc cgcacggcga gcgcaccact
     8521 tccaccggac actcctatcc ggtcttcgac gagatcgagc tgtgggcgcc gtcgcccgtg
     8581 ccgacctggg tggtgctgct ggaggcggcg accgaggccg accgggacgc gctggagcag
     8641 ctggccgccg acgcggggtt cgcggcggag gactggtcct cctccgtgcg gctgctgtgc
     8701 cggatgtgtt cggagtcgcg gatgccgtcc gacgaggggg agggcgtgca tctcgatccc
     8761 cacgaccaca gtgagccggg ccatcccggt cccctggggc atcggacgga cggccagctg
     8821 tgggtgccgg agcgggagtg cggcatcgcc gcgccggctt cgctggtccg ggggctgctg
     8881 gacgggtggg tcgccgacag tccggactcc cgggactggc gggatctcga agaggtctgt
     8941 tgatcgccgc cgcccggtgg cggacggtcc tggctggtcg cgcccacgcg gcggggccgc
     9001 aaaggacaca gacccgcgcc ccttccaggc gcgtccacgt accctgtatc cgctagtccc
     9061 cccatgtttg ttttgaggaa ggcgtcactc ggtcatggct cagcaggaca ccgatcagca
     9121 gcacgcgggc gtgctccccg tcgatgacga gggctatgtc gtcgacaccg aggactgcga
     9181 ggagcgcgag accggctggc gcgagcgcgg gacctcgcgg ccgatcacgg tcgtcgggaa
     9241 cccggtgctg cacaaggagt gcgcggacgt caccgagttc ggccccgagc tggagcagct
     9301 ggtcgcggac atgttcgcca gccagcgcac cgccgagggc gtgggcctgg ccgccaacca
     9361 gatcggcgtg agccggaagg tcttcgtcta cgactgcccc gacgacgacg gcgtccgcca
     9421 caccggtgtg gtcgtcaacc ccaagctggt cgaactcccc gccgccgccc gccgcctgga
     9481 cgacagcaac gagggctgcc tgtccgtgcc caccgcgtac gcgccgctcg cgcgccccga
     9541 ctacgccgag gtgaccgggc aggacgagaa gggcaacccc atcaaggtgc gcggcaccgg
     9601 ctacttcgcc cgctgcctcc agcacgagac cgaccacctg tacggctacc tctacatcga
     9661 ccgcctctcc aagcgggacc gcagggacgc gctgcggcag atggccgaga acgaaccccg
     9721 ctacgacgtg gtcgccaacg actgacggga gcgcgcggaa ccagcgccac cgcaccgaac
     9781 agccacgacg cccggccgga gaccattccg gccgggcgtc gcggctgttc gttcatctgt
     9841 tcgccgaaaa aaacccggcg acttggggta gtgaaaggag caaatccgtt ccccagacgg
     9901 tcagttgtag tgctgaatag gggtgcgggg atacgcaacg gcgcacgccc ggcacggcag
     9961 ggaggggcgt gtgctcctgg cgttcgagag gggactgttc gtgcatgctt tctcaagcgg
    10021 cgccacatcg gcgacagcgg tcgcggtacc accgtctctc gcgctcccgg tgatcgagga
    10081 cgcctttccc cgtcggctgc acccgtattg gccgcggctc caggagaaca cccggcggtg
    10141 gctgctggaa aaacggctga tgtccccgga caaggtccgc gagtacgccg acgacctgtg
    10201 ctacacggac ctgatggccg gctactacct gggcgccccc gacgacgtcc tgcaggccat
    10261 cgccgactac agcgcgtggt tcttcgtctg ggacgaccgg cacgaccgtg acatcgtgca
    10321 cggcaggacc gaggactggg ggcggctgcg ccgccgtctc cacacggcgc tcgacgcacc
    10381 cgaggaccac ctgcaccacg aggacgcgct ggtggccgct ttcgcggaca gcgtgctgcg
    10441 gctctacgcg ttcctgccgg ccgcctggaa ccagcggttc gcccggcact tccacgaggt
    10501 gatcgaggcg tacgaccggg agttcgacaa ccgggtcgcg ggccgggtgc ccggtgtcga
    10561 ggagtacctc gcgctccggc ggctcacctt cgcgcactgg atatggaccg acctcctgga
    10621 accgagcgcc ggctgccaac tcccggactc ggtgcggaag aacccggcct ttcggcgcgc
    10681 ggccctgttg agccaggaat tcgccgcctg gtacaacgac ctctgctcgc tgccgaagga
    10741 gatagcgggc gacgaggtgc acaatctcgg aataagcctc atcacccatt ccgggctcac
    10801 cctcgaagaa gccgtcgaag aactcaggcg gcgcatcgag aactgcatcg ccgaattcgt
    10861 cgaggccgag cgagaggcga tggagttcgc cggagaactc gacgacggca ccgtgcgcgg
    10921 aaaggaactg agcaccgccg tacggacctg cgtcggcaat atgcggaact ggttcagcac
    10981 cgtctactgg ttccaccacg agtccggccg ctacatggtc gacacctggg aggaccggtc
    11041 cacacccccg tacgtcaaca acgaagcggc aggtgagaaa tgaccgtcga cgccgtcaat
    11101 cccgagacgc gggaagtggc cgatctgaag gacccgcccc tcgccggggg cgccgtcccg
    11161 gtgctcgggc acggcctgaa actggcccgc gacccgctcg cgttcatgac ccaactgcgc
    11221 gaccacggcg aggtggtgcg cctgaagctc ggccccaaga cggtgtacgc cgtcaccgcg
    11281 ccggcgctca ccggcgcact cgcgctgagc cccgactaca agatcgacgg gccggtgtgg
    11341 gagtcgctgg aggggctcct cggcaagcag ggcgtggcca ccgccaacgg cccgctgcac
    11401 cggcggcagc gccgcaccat ccagcccgcg ttccggctcg ccgcgatccc cgcctacggg
    11461 ccgatcatgg aggaggaggc gcacgccctc accgagcgct ggcggcccgg cgtgcccgtc
    11521 gacgccacct ccgagtcctt ccgggtcgcg gtgcgcatcg cggcccgctg cctgctgcgc
    11581 ggccagtaca tggacgagcg cgcggagcgg ctcagcaccg acctcgccac cgtcttccgg
    11641 ggcatgtacc ggcgcatggt gctgccgctg gggccgctgt accggctgcc gttcccgtcc
    11701 aacctcgaat tcaaccgggc actggccgat ctgcatctgc tggtggacga gatcgtcacc
    11761 gagcggaggg cgtccggtca aaagccggac gatttgctga cggctttgct ggaggcgaag
    11821 gacgacaatg gcgaccccat cagcgaacag gagatccacg accaggtcgt cgccatactc
    11881 acccccggaa gcgagacaat cgcgtccacg atcatgtggc tcctgcagat cctcgcggac
    11941 catcccgggc acgcggagaa ggtgcgagcg gaagttgaat cggtaaccgg tggcgcgccg
    12001 gtcggattcg agcacgtacg caggctgagc cacaccaaca atgtcgtcgt cgaggccctc
    12061 cgactccggc ccgccgtatg gatattgacg cgtcgcgcgc tcaccgacac cgcactcggt
    12121 gcctatcgca ttccggccgg ggcggacatc atctacagcc cctacgcgat tcagcgcgac
    12181 gcccgctcct acgcccgcca cctcgacttc gaccccgacc ggtggctgcc ggagcgggcc
    12241 gaggaggtgc cgaagtacgc catgagcccc ttcagtgtcg gcaaccgcaa gtgccccagc
    12301 gaccacttct ccatggccca gctgagcctg atcgtcgcgg cgatatcggc gaagtaccgg
    12361 ttccgtcagg tcgaggactc ggacgccacg acccgcgtgg gcatcactct gcgtccgcac
    12421 cgactgctgg tcgagcccat ggagtggtga ggagcgaggc gaccggaccg gcgtgcgttc
    12481 aggcggcctg cgggccccgg aacgcacgcc ggtaggcgtt cggggtggtg ccgagcgccc
    12541 ggacgaactg gtggcgcagc gccgccgcgt tgccgaaccc ggtccgccag gcgatcgagt
    12601 ccaccgtctc gtcggtcccc tccagcaacc gctgggccag cagcacccgt tgccgcagaa
    12661 tccagcggta cggggtggtg ccggtctcct gctggaagcg gcgggcgaac gtgcgcgggg
    12721 acatgtgggc gcgggcggcg agctgctcga cggtgacctc ctggtcgagg tgctcctcca
    12781 tccacaccag cacctcgccc acggtgtcgc agggcgcctt gggcagcggg cgctcgatgt
    12841 actgggcctg gccgccgtcc cggtgcgggg gcaccaccat ccggcgggcg atcttgttgg
    12901 cgacctcggg cccctgctcc ttgcgcacca ggtggaggca ggcgtcgatg ccggccgccg
    12961 tgccggccga ggtgatcacc gggtcctcgt cgacgtagag cacgtccggc tcgaccgtga
    13021 ggcgcgggtg gcgccggctc agttcctcgg cgttgtgcca gtgcaccgcg caccggcgcc
    13081 cgtccagcag cccggcctcg gccagcacga acaccccggt gcacacgctg agcacccgtg
    13141 cgccgcgggc cacggcccgg cgcagggcgt ccagcagggc ggggggatag tcgcgggagg
    13201 tgtaggactc gccggccggg acggcgatca gatcggcctc ctccagccgc tccagaccgt
    13261 gcggggtgga gacggtgaag ccgcagtggg tgcgcagggt gggcccctcc gccgaggcca
    13321 cggcgaagtc gtagaccggc agtccgtcat cgctccggtc gatgccgaac acctcgcaca
    13381 ccacccccag ctcgaagggg tgcaccccgt ccagcaggac cgcgaccacg ttcttcagca
    13441 tgctgccagt gtgcctcggc gctggcagga attcgagggc ctacggcagt cctgccagtg
    13501 ttggacagga gcgttcagcg cgaggctgat gacatgaacg gaaaccagat cgaaggtctc
    13561 atcggaatgg ccgccactct cggcatcctg gtcctcctgg tcctgccctc ggtgatcggc
    13621 atcgtgcgcg aacggcgcgt cgaccgacag ctcgggcagg cccagaagga ccgaggacag
    13681 gagacggcga cggctcagaa gtcctcgtcc aggtccacgg tgccctccac cgcgacctgg
    13741 tacgccgacg ggcggcgctc gaagaagttc gtcagctcct gaacaccctg cagctccatg
    13801 aaggagaagg ggttctccga gccgtactcc ggggcgaagc cgagacgcgt gaggcgctgg
    13861 tcggcgacgc actccaggta ctgccgcatc gactcggtgt tcatgccggg caggccgtca
    13921 ccgcacaggt cgcgcgcgaa ctgcagctcg gcctcgacgg cctcccggag catgtccttc
    13981 acctgctgct cgagctggtc gtcgaacagc tccggctcct ccttgcgcac ggtgtcgacc
    14041 acgtcgaagg cgaacgacat gtgcatcgtc tcgtcgcgga acacccagtt ggtgccggtc
    14101 gccaggccgt gcagcagacc ccggctgcgg aaccagtaga cgtacgcgaa ggcgccgtag
    14161 aagaacaggc cctcgatgca cgcggcgaag cagatcaggt tcagcaggaa cttgcggcgg
    14221 tccgccttgg tctccagccg gtccagcttg tcgaccgagt cgatccactt gaagcagaac
    14281 tcggccttct cgcggatgga ggggatgttc tccaccgccg cgaaggccgc cgtgcggtcc
    14341 tccgggtcgg gcaggtaggt gtcgagcagc gtcagataga actggacgtg cacagcctcc
    14401 tcgaagagct gccggctcag gtagagccgc gcctcggggg agttgatgtg cttgtacagc
    14461 gtcagcacca ggttgttcgc cacgatcgag tcacccgtgg cgaagaacgc caccaggcgg
    14521 ccgatcaggt gctgctcctc gggggagagc ttcgccaggt cggcgacgtc cgagtggagg
    14581 tcgacctcct cgacggtcca ggtgttcttg atcgcgtccc ggtagcgctc gtagaagtcc
    14641 gggtagcgca tggggcggag agtcagctcg aagccggggt cgagcaggtt cttctcggtc
    14701 atcactggca ggcctcgcag gactcggggt tttccaggga gcaggcgacg gcgtcggggt
    14761 cggccgcctg ctggacgggg atggtcttgg tctcctgggc gcggcccgcc gcacgggcga
    14821 tccgggtcgc cgggcgcgaa cgcaggtagt acgtggtctt cagacccgac ttccaggcgt
    14881 aggagtacat cgaggagagc ttgccgatgg tcggcgtctc caggaacagg ttcagcgact
    14941 gcgcctggtc gaggaacggg gtacgggcgg cggccatgtc gatcaggccg cgctgcggga
    15001 tctcccaggc cgtgcggtac aggttccgca cgtcctcggg aatccaggcg aagccctgca
    15061 ccgagccgtt ggcctcgcgc agctcctcac gggtgcgggc gtcccacacg ccgaggttct
    15121 tcagctcctg caccaggtag gcgttgacct ggaggaactc gcccgacagc gtctcgcgct
    15181 tgaacaggtt ggacacctgc ggctcgatgc actcgtacac gcccgcgatg gaggcgatgg
    15241 tggccgtcgg cgcgatcgcc agcagcagcg agttgcgcat gccgacctcg gcgatccggg
    15301 cgcgcagcgc ggcccagcgc tccggccagg tgagctcgac gtcgtagtgg tcggggtgca
    15361 gcacgccgcg ggcggtacgg gtctgctccc aggcggggag cgggccgttg cgctcggcga
    15421 ggtcggcgga cgcctcgtag gaggccagca tgatgcgctc ggcgatccgc gtggacagcg
    15481 ccttcgcctc gggggagtcg aaggggatgc gcagcttgaa gaagacgtcc tgcagaccca
    15541 tcgcgcccag gcccaccggg cgccacttgg cgttggaacg gcccgcctgc tcggtcgggt
    15601 agaagttgat gtccacgacc cggtcgagga aggtcacggc ggtgcggacg gtctcgtcca
    15661 gccgctccca gtcgatgtcc ccgtcggcca cgaaggcgcc caggttcacc gagccgaggt
    15721 tgcagaccgc ggtctccccg tcgtcggtga cctccaggat ctccgtgcac aggttggagg
    15781 agtggaccac gttgcccggc agcgccgtct ggttggcggt gcggttggcg gcgtccttga
    15841 aggtcatcca gccgttgccg gtctgcgcga gggtgcgcat catgcggccg tacagctcgc
    15901 gggccggcat ggacttcctc gccaggcccg cctcctcggc cttgcggtag gccgcgtcga
    15961 actccgggcc ccacaggtcg accagctcgg gcacgtccgc cggggagaac agcgaccacg
    16021 actcgtcggc gttgacccgg cgcatgaact cgtccgggac ccagtgcgcg aggttcaggt
    16081 tgtgcgtacg gcgcgcgtcc tcaccggtgt tgtcgcgcag ctccaggaac tcctcgatgt
    16141 cggagtgcca ggtctccagg tacaccgcgg ccgcgccctt gcgccgcccg ccctggttca
    16201 ccgcggccac cgaggcgtcc agcgtcttca ggaacgggac gatgccgttg gagtggccgt
    16261 tggtgccccg gatcagcgaa ccccggctgc ggatgcggga gtacgagagg ccgatgccgc
    16321 cggcgtgctt ggagagtcgg gcgacctggt ggtagcggtc gtagatcgag tccagctcgt
    16381 ccagcgggga gtccagcagg tagcaggacg acatctgggg gtgccgcgta ccggagttga
    16441 acagggtggg ggaggacggc aggtagtcca ggcggctcat cagcccgtac agggccgcga
    16501 cctcgtccac ggccgggacg ctgtcgttct ccgccagacc gctcgccacg cgcagcatga
    16561 agtgctgggg ggtctcgatc accttgcggg tgatggggtg gcggagcagg tagcggctgt
    16621 acagggtgcg caggccgaag tagccgaacc ggtcgtcggc gccggtgtcg atcagggcgt
    16681 ccagccgggc ggcgtgcagc gccacgaagt ccgcggtgcg gtcggcgacc aggccctcgc
    16741 gatggcccac ggccaccgac tcggtgaagc gggtcacgcc ctgcgaggcg gcctcggcgc
    16801 ggatggagag cgtgagcagc cgggcggcca gccgggagta cgccgggtcc tccgagatca
    16861 gaccggcggc ggcctcggtg gccagctcgc gcagctccgc ctcgtcggcg cgcgccgacc
    16921 ggccgcgcag cgcggcggcc gcgacccgac cggggtccgc gtcggggagg tcggcggtca
    16981 gctgggtcag ggtccgcagc agcgcggcac cggggccgtc gttctccaca ggggcctcgg
    17041 tcgccggggt ggctgaagcc ggatcggcag gcgcgatggt cacgtggggc tctccctcgc
    17101 tgggcacggg gacctggcgg agggtatgag ggggcacgag cgcacggggc gtcgcgtcca
    17161 ccggcccact ccacgaggcc cggacgtctt cgagcacccg ggccggacgg ccgggcgccg
    17221 ctgtcgacag gtcctcggac tgacgctggc gtgcacgaag cacgcgagta caccgttgcg
    17281 ggacagttcc ggattcgcac cggattcccc tgcgacgaca gcgagcacga gcatacatct
    17341 agtgccgccc tgtcacgtca cccccagatg ttgtgtctgt tgtgtgtccc ggtggcttca
    17401 gagggtcaac tcgtaggcgc gggggacgag gtccgggacg cccggcggcg cgtacgacga
    17461 cgggccgccg gcgctctcgc gtcacggcgg cccgcggcct gaagggaggg acttctagtg
    17521 gctgctgccc gctgtcgccg gggggagttc gacctccaca ccggggtcgc cggcgtcggc
    17581 ggtgtagtcg gccggggtgg tctcgtcgat gccgtcgggg gccttcacgg ccttgaggac
    17641 gaaggtgagg accacggtga cgacgacgtt caggacgaag gacgtcaggc cgatgtagcc
    17701 gatctcgccg atgccgggga tctccttggc ggagccgccg aagtgcttct gggtggggga
    17761 ggcgacaccg taggcggcga gggtgccgta gaccatgccg accgcccagc cggccagcag
    17821 ggcccagcgg tggaaccagc gggtgaacag gccgccgacc agggcgggga aggtctggag
    17881 gatccagatg ccgcccagca gctggaagtt gatggcgacc gtcttgtcca tggtgaggac
    17941 gaagaccagc gcgcccacct tcaccagcag cgagaccagc ttggagacct tggtctcctg
    18001 ctcgggcgtc gcgtcgggct tgatgaagtc cttgtagatg ttgcgggtga acaggttcgc
    18061 ggccgcgatc gacatgatcg ccgccgggac gagcgcgccg ataccgatcg ccgcgaacgc
    18121 cacgcccgcg aaccagtccg ggaacatgtc ctcgaacagc tgcgggatgg cgagctgccc
    18181 gttggtgacc ttcaccccgg ccgcgatggc catgaagccc agcagcgcca gcaggcccag
    18241 catcagggag tacagcggca ggatcgtggt gttgcgccgg atcacgtcgc ggctcttgga
    18301 ggagagggtc gcggtgatcg agtgcgggta catgaacagg gcgagcgccg agcccaacgc
    18361 cagcgtggcg taggtccact ggcccgccgg ggccgggacg acgccgcccg caccggccgc
    18421 cgcgtacttc tcgcccgcct tggcgaagat ctcgtcgaag ccgcccagct tgatcgggat
    18481 gtagatgatc gccaccgcga tgacgatgta gatcagcgtg tccttcacga acgcgatcat
    18541 cgccggtgcc cgcagacccg aggagtacgt gtacgccgcc agcacgccga aggcgatcag
    18601 cagcggcagg tccttcacga accagttggt gtcctcaccg ccgcccacgc ccatcacgtc
    18661 cagcaccgcc tggatgccga ccagttgcag cgcgatgtac ggcatcgtcg ccaggatgcc
    18721 ggtgaccgcc accgccagcg agagaccctt ggagccgaac cgcccgcgca cgaagtcgga
    18781 ggtggtgacg tacccgtgcc ggtgcgagac cgaccacagc cggggcagga aggtgaagat
    18841 cagcgggtac accaggatcg tgtacggcac cgcgaagaac ccggacgcgc cggccgcgta
    18901 gatcgccgcc ggcaccgcga cgaaggtgta cgcggtgtac aggtcgccgc cgagcaggaa
    18961 ccaggtgatc caggtgccga acgaccggcc gcccaggccc cattcgtcca gcgagtgctc
    19021 gttctcggcc ttgcgccagc gcgaggcgag gaagcccagg accgtgaccg cgaggaagaa
    19081 gaagacgaag acgccgagcg ccacgccgtt gacgccgtcc ttcacttcga gacacccccg
    19141 ctccgggtct tgcgggagcg ctggtcgcgc tgccagagct ggtacgcggt catggtgagc
    19201 gaggtggaga ccagcaccca cagcatctgg taccagtaga agaacgggat gccgatgaac
    19261 gtcgggtcca ccttggagaa cgaacccacc cacagcatcg ccacgaacgg cgccacgaga
    19321 cacagcccga tgaccactcg gaccggtgtc accaccggtt gcctcacttc agaatcttcg
    19381 ggcatgccgg actccgtccc ctcgttgatc acgcgtaatg cgcacgcaat ctaggtgacg
    19441 gcacggcgga gcggaagccc tcgtccgggt atcgatacgg cgatgtgagc tggtggggcc
    19501 cgagaagcgg ggggacggag ccggtcagtc ctgcggacgc cggagccgcg ccacgaactt
    19561 gtaccggtcg ccccggtaca ccgagcgcac ccactccacc gggcggccct cccggtccac
    19621 cgagtgccgg gacagcagca gcatcggcag gcccacgtcg gtgccgagca ggctcgcctc
    19681 gcgcggggtc gccagcgagg tctcgatggt ctcctcggcc tcggccaggt ggacgtcgta
    19741 gacctcggcg agcgcggtgt acagcgaggt gtacttcacc agagaacggc gcagcgcggg
    19801 aaagcgcttg gcggagaggt gggtggtctc tatggccatc ggctcggcgt tggccatgcg
    19861 cagccgctcg atgcgcagca cccggccccc ggcgcttatg tccagcagcc cggccagccg
    19921 gtcgtcggcc gtgatgtagc cgatgtccag cagctgagag gtgggttcga gcccctgggc
    19981 ccgcatgtcc tcggtgtaag aggtgagttg gagcgcctgg gcgaccttgg gcttggcgac
    20041 gaaggtgccc ttgccctgga tgcgctccag ccgcccctcg accaccagct cctggagggc
    20101 ctggcggacg gtggtgcggg aggtgtcgaa ctcggcggcc agcgtgcgct cgggcggcac
    20161 cggcgtgccc ggcggaagcg tctccgtcat ctcctggagg tgcttcttca ggcggtagta
    20221 cttcggcacg cgcgcggtac ggacggtcgc gccggcctcg ttctccgccc tgctgacgtc
    20281 ggtgctcatg gctgccttcc cggctccgga tgcccatggc gaccgacatc gccatcggtc
    20341 acggctcaca tcgtggcacg gccgcgcgcg gccggttcac ccgcacgctc cgtgatctcc
    20401 ctgtataccg ccgcaccccc ggttggtcta gtccacccgc gtccggcggg gcagtggtcc
    20461 accggaactg gtccgtccga tctgtcggtt gcgcaatgaa aggtccctgc atatctcggt
    20521 cgcgtcacgg acgcccggac cccacctgaa cacccttgac agcccttttg gtctgggcca
    20581 agctccccct gctggtctac accattggtc cagtcccggc tccgagggcg gtacgacgcg
    20641 caagtgtgac accgcgggga ggcagggggg ttgtgggcat ccctgaggag gatggcgtga
    20701 agcgcagact gatagccgcg atcggcgtcg cgggcatgat cgtctccatc gccgcgtgcg
    20761 gcagtgacga cggcgagggc aaggggggcg acagcgacgc gctgaccgtc tggctcaccg
    20821 tcgacgcgca gaacaactgg ccgaacctgg tcgaggccgc cgacgccgcc gtggtgaaga
    20881 agcacccggg cctgaagatc aagcacgagt actacggctg gccggacaag aacaccaagc
    20941 tggacgccgt cctcgccacc gacaaggctc ccgatgtggt cgagatgggc aacagcgaga
    21001 tgctcggcta catggtgaag ggcgccttcg cccccctgga gcccggcaag ttcgagggct
    21061 cggacgcctg gctggacggc ctc
//
