LOCUS       NZ_SHKU01000001        25187 bp    DNA     linear   CON 27-MAY-2024
DEFINITION  Streptomyces sp. BK022 Ga0307664_101, whole genome shotgun sequence.
ACCESSION   NZ_SHKU01000001
VERSION     NZ_SHKU01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. BK022
  ORGANISM  Streptomyces sp. BK022
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1305487)
  AUTHORS   Kalluri,U.
  TITLE     Understanding the reciprocal impacts of modified plant cell wall and
            associated microbiome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1305487)
  AUTHORS   Kalluri,U., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 215.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004217355.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 02:58:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,482
            CDSs (total)                      :: 6,401
            Genes (coding)                    :: 6,280
            CDSs (with protein)               :: 6,280
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 49 of 121
            Pseudo Genes (incomplete)         :: 92 of 121
            Pseudo Genes (internal stop)      :: 16 of 121
            Pseudo Genes (multiple problems)  :: 29 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:05:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 455591
            Orig. end                         :: 480778
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SHKU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..25187
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25187
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25187
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15187](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15187)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(354..749)
                     /locus_tag="EV284_RS33060"
     CDS             complement(354..749)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019846.4"
                     /locus_tag="EV284_RS33060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="methyltransferase domain-containing protein"
                     /protein_id="WP_242625517.1"
                     /transl_table=11
                     /translation="MPYTPRVPERLGWTPWEGIGPGAEVLGDVTGRRVLDIGSGAGHHA
                     VHLAQAHGARVTGIELSPTQTADASPTLSPGAASSASSTIWKPASFRAWRTRPTSWGRT
                     DGTPSPAPKESDHAIGCCGPNRSSSRP"
     gene            complement(842..1735)
                     /locus_tag="EV284_RS02100"
                     /old_locus_tag="EV284_0426"
     CDS             complement(842..1735)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978526.1"
                     /locus_tag="EV284_RS02100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0426"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_242625518.1"
                     /transl_table=11
                     /translation="MPEQALPAVPNPSAGDEPHEHHMHLLGRYYRQVEAGRKTIEVRVA
                     TPHKRDIIVGDTVVFHDRDTGRELDVLVQRITPYPSFEDLLHSEDAARIDPDGPPGELL
                     ANLRGIYPSAKEALGVLALAFGHRPARPGRPMPMTAEEYAQTVPHHTVYGCLYIRDEHD
                     RPVQLRSVYGSRLWQFPGGNLDALGEDPLQTARREAVEETGLELALNAPILLLTHFLHA
                     GPRLPLNKMGLIFDGGRLTAEQLGRIRLDPAEHDMWAVHDLATWQELMAPRAFARLDAI
                     ERARRGEGPAYLITHT"
     gene            complement(1865..3133)
                     /locus_tag="EV284_RS32915"
                     /old_locus_tag="EV284_0427"
     CDS             complement(1865..3133)
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016805 - dipeptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579846.1"
                     /locus_tag="EV284_RS32915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0427"
                     /product="M15 family metallopeptidase"
                     /protein_id="WP_242625519.1"
                     /transl_table=11
                     /translation="MTGTTNRAHRRVSTATAAGREDTRLVVIRGNSASGKSSVAQGLRD
                     HHGRGVAIVGQYLIRRNVLREHDTARGANIALLSRIARDALNAGFHVVLEGILYADRYS
                     HMITSLVRDHRGVSRCYYLDVPLEATFVRHASKADAAYLAQVTDSHLTSWYREMDLLPG
                     GLETVIPADSTLQDTVARMVRETDLASASPVPPPQCKLSQGDSMNPLVLMSDPRVAAVP
                     VRESGEPLVDLRDHDFRVDPRKQDPLGAFAHVREGVLARLQHARSLLPAGTDLLFIEGY
                     RPLSLQQLYFTEYRNQLAAAQPGWTAEQLHQAASRYVSPPEIAPHSAGAAVDVTLVDQD
                     GHELDLGTRVNASPEESGGACFTHAPDLSDHARRHRTLLLNAMEGAGFTNYGTEFWHFS
                     VADRYDALMRQEPHARYGPIELP"
     gene            complement(3130..4617)
                     /locus_tag="EV284_RS02115"
                     /old_locus_tag="EV284_0428"
     CDS             complement(3130..4617)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015579847.1"
                     /locus_tag="EV284_RS02115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0428"
                     /product="NUDIX domain-containing protein"
                     /protein_id="WP_130329657.1"
                     /transl_table=11
                     /translation="MPLSHDHIRTTVDAYLARHPHEREQLGGLLDALNRTGDEIASRST
                     FTGHVTCGAIVIDPLGRVLHGLHLASGKVLAPGGHTEPTDQSLAAAALRELHEETGIPP
                     QAVTPWPGYETVPFDIDIHHIDANPGKDEPGHQHFELRFLFRLHTANEVEVMLQEEEVG
                     GIEWRPVDRAASPSLREKLLKLPLQVEPETANASALIYNDRGEYLLHLRDYFPGEIWEP
                     GMWSLLGGGRESQDATLEHTVRRELAEEAGLDIADLTPFGTEYASDEAGAVVPIAIYAG
                     RWNGDPRKLRLTEGVMLAWFAPDDLHRLRIADTTSDLVRRHAAGRPASTTSQSGLPSPE
                     ERRPASPNGTVLNVIGVHLYLERPDGTVLLGLRHPNSKFAPSTWHALAGHCEQENAIAC
                     LIREAREEAGLRIQRQDVELVHVVHHIDKAGDRPRMGLFFRARAWSGEPELREPDKCTE
                     WKFWDPAALPDDLVSYTRVAIRKIQNGELYSETGWPA"
     misc_feature    complement(4595..4611)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            complement(4676..5152)
                     /locus_tag="EV284_RS02120"
                     /old_locus_tag="EV284_0429"
     CDS             complement(4676..5152)
                     /EC_number="3.6.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012514.4"
                     /locus_tag="EV284_RS02120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0429"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_242625520.1"
                     /transl_table=11
                     /translation="MSRHAAWIGAAAIITDEVGRVLLVMLPGGTVETTDATPEDTLYRE
                     AAEEAQLTLADPVRLGWVLDETGEVYGGVGPNARVRLAARVTAVGPAAVDRATGHPFAR
                     LLVTPAQAAALLGWGPPGARQAQLAAETARKWWGLPIARTAAVEEIPSEGMRLS"
     gene            complement(5300..6595)
                     /gene="fxlM"
                     /locus_tag="EV284_RS02125"
                     /old_locus_tag="EV284_0430"
     CDS             complement(5300..6595)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="EV284_RS02125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0430"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_165425442.1"
                     /sec_met_domain="PCMT (E-value: 3.7e-28, bitscore: 94.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="Methyltransf_3 (E-value: 4.9e-06,
                     bitscore: 22.1, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTSPATEVSDASELRHQLVEQLRAGSHIRSAAVERAFRTVPRHA
                     FAPEIPLPAAYANDIVPTRHSDDGRVTSSISAPWLQAEMLEAARIQAGHRVLEIGSGGC
                     NAALLAQLVGPTGHITTLDIDPAVTDRALRFLPQAGYDHVSVVTADAEHLPAGVVPDGG
                     FDAILVTVDTWDLPWIDALAEGGRLVAPLRLHGYHWAIGFTRKEGALHSDEPLIICGFV
                     AMQGDGAWNTNRRTVPGTGVHLSWEDGTPLPVDQLASALTREPTVTRTNVTVGGQEPFD
                     ALTLYLAGALPGFCRLEADSEGDNKVLNPPLRHWPAAAIVRGGSLARLATERIGEGDDG
                     KGRYEFVVHGYGDQGHGSAQEMAEQVQHWQLNHRGARCPLITARPAADPAPAGTDHEPH
                     VFAKKHTRITVDWPIVPGSAAGPTSPGSCDAG"
     gene            complement(6708..8648)
                     /locus_tag="EV284_RS02130"
                     /old_locus_tag="EV284_0431"
     CDS             complement(6708..8648)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007389174.1"
                     /locus_tag="EV284_RS02130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0431"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_130329661.1"
                     /transl_table=11
                     /translation="MTSAITRDQPPQPPKGTAPDQEAQEASVREEEYLYRDESRLQAGS
                     LLTSRTMARRLPSLVRRSVQMAWRVDRGATIGLLVCQIGTGVLAALGLLAVTGTITALI
                     SSGDITERLWDAAPQLAVIAAATGLRALLGIAVVWLTGRLRPVLGRAAELTMIEAALGA
                     ELAANNKPGYNDAYDIADRGAQVTPDLVEEAQDVLAATATLTAGATVLTVLHPLLLPLL
                     FLACLPQAAAYIRSARVLYLAALETSGRRRMLGKLRWHMAYMESSEEMRACLAGPFLIG
                     RYRKLAASVNAAERKAANTGAWMGLAGAVAGGIASTAVWAALLWLLASGRMSLAAGGGA
                     VFALQTATGSVRGIINGGARLVRTGWYVQDWQNFLDNAHGQAMTDSRGTAPVPAAPERF
                     EVRDVTYRYDGAPKDSLSCVSLHVRRGEIVALVGENGSGKTTLSRLLCGLLLPTEGDVA
                     WDHASTADLDPWGSWKHVALVPQKFTYLPLTMRDNITFGQGDTSDAALLAACEASGAAE
                     MLPVLRSGLNTLLTSEWFGGQQLSGGQWQRLVLTRAFHRQAALLVMDEPTAALDARAEH
                     RIFAGLRELAKDRAVLLITHRLTNVAVADRIVVLNEGRIVQEGTYAQLTQQPGLFRTLW
                     ELQRRMSGDTP"
     misc_feature    complement(8636..8650)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            complement(8884..9984)
                     /locus_tag="EV284_RS02135"
                     /old_locus_tag="EV284_0432"
     CDS             complement(8884..9984)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346481.1"
                     /locus_tag="EV284_RS02135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0432"
                     /product="hypothetical protein"
                     /protein_id="WP_242625521.1"
                     /transl_table=11
                     /translation="MASRIPLVPRTKAPALPLEERINHLTGLTVAPAGASHHDLVARAC
                     GVLNYAALIASDVGLPDLAEDLCWRQHQVFANAGRLSGRVAVMSLMPLVNLSRLQTRAG
                     HGELAYGLLYCLNDAARHRNKTDIDGRTVDLSALTGTDEDHRTVCQELYVTLLVDGARA
                     LARIGRWSEAADAMAQHRGIGNRLLDGRQIKIMALMEQGLDQQARDLIDTTQPAEPWER
                     AIALLLHAHCQPAHAPVPEPDLDRTMDEAVQLLAHPDPPTAAFQTRTGLSALELDGTGR
                     HSDRVLDSLVSVARLDAYAARDALRHPVAASALDGGATDALHAVIVAAGLGSGFLSAQH
                     HEALASAVGRAETELERLLQAEPDPR"
     gene            complement(10001..12046)
                     /gene="fxlM"
                     /locus_tag="EV284_RS02140"
                     /old_locus_tag="EV284_0433"
     CDS             complement(10001..12046)
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346482.1"
                     /locus_tag="EV284_RS02140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0433"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_130329665.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.5e-19, bitscore:
                     65.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PCMT (E-value: 6e-42, bitscore: 139.9,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDEENLPVPPDTSWWHASVAFPDPHADAAPALATALGERRFHF
                     LRKDAGVRLRTEQPVADLLDQLVADRVITGWVGGIYEPETHAFGGPEGMEVAHDVFCAD
                     SPAALAETGTPGARERSVMLLSAMIRAAGLDPFEAGDVWGRWAALRPPVTPPQGPALDQ
                     AVSAMRRLMNADAALRPDAEAGWVERVAEFEDAGRRLRRLAADGRLIRGIRAVIAHHAI
                     FAFNRAGVPADVQAATAWLGRHVAFSTGEGADVSTRKSASADPSLPRMETTVTPVTDPK
                     QLREALAQRLVDSGHLSSQAAIDAFRSTDRHAFLPGVDLESAYKEDAVPIKHDEHGEMI
                     SCISAPSIVATQLEQLGAQPGHKVLEAGAATGYNAALLGKIVSPGGQVWTLDVDQDLVA
                     GASKHLAKAGVDNATAVMADGAAGLPEHAPYDRIIFTVGAGDVPVKILDQLAPGGRLVL
                     PMRIRGSISRSFAFERDGDTWKTVSCEMATFIPLRKGVCDDVYTLVPMAGEGNVRLETF
                     SEQDVDREALRSVLDEQQTKIYTGVKFRQGSAWEWLYLYLACVLPNGLSRLPGQRPGFT
                     PHFGWGSMAALDGGSLAYLTIREGEDKQGRYWEVGVIGHGEGRADIAERVVSEIRAWDA
                     TGGNNAPEPGFRMAVADSRTRLTADDPRFVVDKPYSRLVVDWARKG"
     gene            complement(12081..13151)
                     /locus_tag="EV284_RS02145"
                     /old_locus_tag="EV284_0434"
     CDS             complement(12081..13151)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009326267.1"
                     /locus_tag="EV284_RS02145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0434"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_130329667.1"
                     /sec_met_domain="LANC_like (E-value: 2.3e-32, bitscore:
                     108.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTTVPRTQDLSEGALGMALLDIERRDLSTARRHLAQATVRGVS
                     TGSNASLFHGAPALEFVLDRAHGAANDVRAAVDRVVDARLAAAHRRQEAGALPHLAEWD
                     LIRGMTGLAALLLSRRPIAPRLPDVLACLVALAHPARSDGRILPGWWSPVGPDGKDMAG
                     GHGNNGMAHGIAGPLAVLSLALRAGVSVPGQEEAVDTFATWLDRHGDHYWSTTAHLDAD
                     QPPPAEPARQSWCYGQPGIARAQQLAALALGDPVRRQAAEDTVEAILTDPLRLARITDS
                     TLCHGWAGLLTLTRAVAADSTSPERFTPIIQDLHRRLAADWEHLPKPGFMEGRAGAQLA
                     LKATDATGWTRVLLLT"
     gene            complement(13148..15187)
                     /locus_tag="EV284_RS02150"
                     /old_locus_tag="EV284_0435"
     CDS             complement(13148..15187)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346484.1"
                     /locus_tag="EV284_RS02150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0435"
                     /product="lantibiotic dehydratase family protein"
                     /protein_id="WP_242625522.1"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.7e-20,
                     bitscore: 69.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_N (E-value: 8.8e-105,
                     bitscore: 347.3, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRHRPSLYEAAGQAMLRAAVHTTEPAMPPWPVAKAPVDEWRAWL
                     STVWSDTDFRRAVSQASPHLADQVQAVIDGRTPKVRRMRRAALATARYAIRYARRSTPY
                     GLFAGVAPLGFAQATSVRFGEKHQAVTRPDPVGLEEILSAWESDAARMADAEVCVNTLI
                     RQRDQHIHVPSEGDAEFRLALSPALRLVLDLARSPITYRQLSDKLAAEFPAVSDTARDR
                     LLGELLRVRLLRSSLRAPATIADPTDVLPPATHTQAAGLRTACDLRLDADVRLPKQVLT
                     ESETAATILARLVTHPNGTPTWRRWIEQFSERYGENTAVPVEAVTDPDRGVGFPAGFVT
                     ASEPPRPMSRRDRLLLELAGTAAAEGSRTVALTGAMIEELEAAAGDKPQALAPHLELAA
                     QVHASSLPALDRGDFRLHVLTVSRSAGSMTGRFWHLLPGTETAYAKLPTVDPEAELAQL
                     SFHAGRVPADLLTRAPQALPRIVSVGEFRRPEPHVLFPRDLAVTVADGRPQLVESATGK
                     PLELLAPTAINFLWNNYTPPMARFLGEISRAASPQVTWFDWGAAWTLPFTPALTYRRTI
                     LTTTRWKIRSRTLPARTARFQQWADQLHAWRARFRVPDRVLLAEDDQQLPLDLTRDVDL
                     DLLRAHLDASPLGIATLHDAPPPDADGWIGGRAHSIVVPLARRS"
     misc_feature    complement(14438..14440)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     aSDomain        complement(14468..14719)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EV284_RS02150_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="6.40E-22"
                     /identifier="RREFam001.1"
                     /label="EV284_RS02150"
                     /locus_tag="EV284_RS02150"
                     /protein_end="240"
                     /protein_start="156"
                     /score="69.1"
                     /tool="antismash"
                     /translation="VCVNTLIRQRDQHIHVPSEGDAEFRLALSPALRLVLDLARSPITY
                     RQLSDKLAAEFPAVSDTARDRLLGELLRVRLLRSSLRAP"
     gene            complement(15275..15463)
                     /locus_tag="EV284_RS02155"
                     /old_locus_tag="EV284_0436"
     CDS             complement(15275..15463)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="EV284_RS02155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0436"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_057608338.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 2.8e-16, bitscore:
                     55.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATETVLMC
                     STGDTCGSSCPSACTTS"
     CDS_motif       complement(15344..15463)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATE"
                     /locus_tag="EV284_RS02155_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15275..15343)
                     /prepeptide="core"
                     /locus_tag="EV284_RS02155_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-9.90"
                     /molecular_weight="1932.2"
                     /monoisotopic_mass="1930.8"
                     /core_sequence="TVLMCSTGDTCGSSCPSACTTS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTAVQTERPTAPVQSDLATTDETDPFGLDITFIEGTPATE"
                     /leader_location="[15343:15463](-)"
                     /alternative_weights="1950.2"
                     /alternative_weights="1968.2"
                     /alternative_weights="1986.2"
                     /alternative_weights="2004.2"
                     /alternative_weights="2022.3"
                     /alternative_weights="2040.3"
     gene            complement(15596..16063)
                     /locus_tag="EV284_RS02160"
                     /old_locus_tag="EV284_0437"
     CDS             complement(15596..16063)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491161.1"
                     /locus_tag="EV284_RS02160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0437"
                     /product="DUF6082 family protein"
                     /protein_id="WP_130329669.1"
                     /transl_table=11
                     /translation="MKLTTAVLAAGAAVSLTTAVVGAVRLREVARHQAERNEAVVARNQ
                     LDWLAQMSTNADLAKLWAPEDMDVEEYMQLLHANQQICTLSLRDRLGFVRDGQLPFYAS
                     MLMNSDVCRRYWARFGDLRAQEAEGDERAEHFTKVLNQAAKAHQEAQPVAA"
     gene            complement(16138..16711)
                     /locus_tag="EV284_RS02165"
                     /old_locus_tag="EV284_0438"
                     /pseudo=""
     CDS             complement(16138..16711)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491163.1"
                     /locus_tag="EV284_RS02165"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0438"
                     /product="DUF6624 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTTDEPQRPDLAREHRPRHGIGHAPGQARARPARRRPTRTGPAHR
                     PRQHQGAAPHPGRPRLARPPPRRPRRGPCRVEHRPAQRRRTRLPARRHHPAGTCGPGRR
                     RAGPALGTPARARPHHQRARPGVRHPAPAVRRRHRVVPAARAGVSRRTQGHRGSAADRC
                     RSEGGAPPVHRAWLCR"
     gene            complement(16708..17358)
                     /locus_tag="EV284_RS02170"
                     /old_locus_tag="EV284_0439"
     CDS             complement(16708..17358)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004920929.1"
                     /locus_tag="EV284_RS02170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0439"
                     /product="hypothetical protein"
                     /protein_id="WP_242625523.1"
                     /transl_table=11
                     /translation="MTRPTTSAASEYRSASVPFTQTPPTAIYEMRMLRTAAEREEAAAL
                     VQDRQRWLTMHGLPVPARADIPALFSEAQTMSAGLYEDGKLLACMIPERDPDLGWGQGP
                     CLFLQSVHTLPGQSDDITRLITLWASDFAARLDLQVVRAETLARHTLEAEPLAALLRRL
                     TDNGWDVCGSGPGRDGDRVARLELPVEHRAGLRALISCQVHAPQPAPDDRSNA"
     gene            complement(17355..17837)
                     /locus_tag="EV284_RS02175"
                     /old_locus_tag="EV284_0440"
     CDS             complement(17355..17837)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143021.1"
                     /locus_tag="EV284_RS02175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0440"
                     /product="LuxR C-terminal-related transcriptional
                     regulator"
                     /protein_id="WP_234386688.1"
                     /transl_table=11
                     /translation="MTTSAPITPLTPTLQRVAQHLANGCASQEIAAKTGLSAVTVRQYI
                     RDIRASLHCPPRCKPPVIVHRLFTTQQVASPTADRPAPKLSPEQLLLLRAVAEHSDTRD
                     IAVAAKLAPADQRAALDQLLADTGAQDTTELVVLAHGWQLLPAEQAAHATRNGASQ"
     gene            complement(17978..19231)
                     /locus_tag="EV284_RS02180"
                     /old_locus_tag="EV284_0441"
     CDS             complement(17978..19231)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325326.1"
                     /locus_tag="EV284_RS02180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0441"
                     /product="acyl-CoA dehydrogenase"
                     /protein_id="WP_130329671.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.4e-23, bitscore:
                     79.2, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 6.2e-19, bitscore:
                     64.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 8.7e-33, bitscore:
                     109.8, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSATPTTPPPALRPYLTARHEVLWDEADAFAAEHIAPRAARMEAA
                     PGRVERKVADLMAARGWFAVTIPAAFGGLGAGHVAKTILVHRIARISAAAAAILQATLI
                     PVGALLHFATYEQKGRWLPRVADGSLLLSIAVTEPQAGGHIGGIETTAERAGSEWVITG
                     SKVHIGNSHLAGAHLVVARTAEAGVSTSQALTAFMVESSRRGLSVPEHRPGLGLHGFSA
                     GRLDLDHVRVPEDNVVGEIGRGLSVAQSSSILYGRPNLAAVSLGIHEAVVAATTARLKT
                     RPRYRGSLSDLPVLRDRIGGMEARLRAGRILAYQSVHLLDQGLPCDADLINAKYLGHQW
                     AAQSAQDAMELHGAHAFDRDYVLQRLWRDIQHTYPPAGTGEVQRLHLADAAFDENHIQW
                     SERLAAEAAWARPDPTAA"
     misc_feature    complement(18077..18079)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19315..19953)
                     /locus_tag="EV284_RS02185"
                     /old_locus_tag="EV284_0442"
     CDS             complement(19315..19953)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016325325.1"
                     /locus_tag="EV284_RS02185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0442"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_130329673.1"
                     /transl_table=11
                     /translation="MSHHPNPYLASPTAPPALSLPRRGTRDAACGPITPPATAVTGPQT
                     QQPPELAQRYELLNRLGVPLVASEDFDDLARDMAAKAGFLYGFVNLFLEEQTFVGLHQP
                     PADSGYFIVGRTMSRDHGWCPEVMARKKALPLHDVHASPRFSGNHVVDAVGIRSYFGAP
                     LVHDSGTVLGTVCVIDPEKRPLSEARRLRDIVINAGAQVMDHMVRAPVR"
     gene            complement(19953..20540)
                     /locus_tag="EV284_RS02190"
                     /old_locus_tag="EV284_0443"
     CDS             complement(19953..20540)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491174.1"
                     /locus_tag="EV284_RS02190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0443"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_165425464.1"
                     /transl_table=11
                     /translation="MLKVVIAGGFGAGKTTAVGAVSEIAPLSTEEYLTEASADVDSLAG
                     IEAKQTTTVAFDFGRLSLPDAPVPLELFLFGTPGQDRFVDLWYALSRGAVGAVVMVDTR
                     RLESSFTPISFFEDIGLPFIVAINQFDGAHRYQPEQVRTALELPASVPVITCDARDPNH
                     VAGVLLTLVGHAVKNASVTRVHHTPTTTLQDA"
     gene            complement(20596..21003)
                     /locus_tag="EV284_RS02195"
                     /old_locus_tag="EV284_0444"
     CDS             complement(20596..21003)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491176.1"
                     /locus_tag="EV284_RS02195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0444"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_057608332.1"
                     /transl_table=11
                     /translation="MSTHGRATEESMFVRTYTLTRGRTRPRHLLGLETVLEAGRGRPGP
                     AQAEECEEILALCRERRRSVVELAGRLGRPVTAVKILVSDLLDADALVVPLTHPYADTG
                     AESGPSTQLLAALSAGLKRKWPDAIAYPQAG"
     gene            complement(21000..21515)
                     /locus_tag="EV284_RS02200"
                     /old_locus_tag="EV284_0445"
     CDS             complement(21000..21515)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011031324.1"
                     /locus_tag="EV284_RS02200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0445"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_130329675.1"
                     /transl_table=11
                     /translation="MSTHPAMDNVTGDAPVTGTTASGQRDNMAWLLRQFASAVPGVTHA
                     VLLSRDGLRLLDSDVDKDWADELSAALSGVASLAANITGPSHKKRPARQVIIERDDCLF
                     FVQSAGRSAAFDNHPGNERGEVDTILAVIATTDADAGTVGFEMGRLVQKFAPYMLIPVR
                     VGTGGEVR"
     gene            complement(21586..23100)
                     /locus_tag="EV284_RS02205"
                     /old_locus_tag="EV284_0446"
     CDS             complement(21586..23100)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143015.1"
                     /locus_tag="EV284_RS02205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0446"
                     /product="ATP-binding protein"
                     /protein_id="WP_130329677.1"
                     /transl_table=11
                     /translation="MPDSAFPARPAATGHRRRRPPIDAFTLHRVRRAVALPLVLLAALL
                     GAAFPLWSVSAVGPGWLLACLVCGLAGVATAAARGARTAAGAVQATAEEDWAAALAAVA
                     GAAAAVEKSVQWSADELCRGGRPPLPDLQAPTSAGPNAEINTALSALQVQAIASLIRVH
                     DESQSVVLLEVLRRLAMREHALVGKALQALSELEMLTDDPELLAKIFEIDHLVTRMRRQ
                     VESTAVLGGQSLRSVRRPIPVATALRGAVSEVVQYPRVSVAAGSVGAELGLPGHVGPDL
                     THLLAELIENACECSDPATKVMVRAQRVANGLAVEVEDRAIPMHPQTRAQMNHLLKAPD
                     EVDVSGQVRAGQLGLLVAAKIAQSHGLSVLLQENVTGGTTALVVIPTRLLVAIPSVDDA
                     TARPQEARPSAPPQQVAAAPAVPTAGQVTHPSNVGAQGAVEAGHSADAPALPTRRRQAG
                     SFRPSREREQAPVTGATPGLAAAFRNGIQAGGRAGSSTASAEQPAP"
     gene            complement(23126..25027)
                     /locus_tag="EV284_RS02210"
                     /old_locus_tag="EV284_0447"
     CDS             complement(23126..25027)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007491181.1"
                     /locus_tag="EV284_RS02210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0447"
                     /product="glycoside hydrolase family 15 protein"
                     /protein_id="WP_130329679.1"
                     /transl_table=11
                     /translation="MKRLPRIEQYGLIGDMQTSAHVCDDGSIDWLCLPRFDSPAVFTGL
                     LGTQKHGTWRIAPAAPADRSSSEAVAERRYRGDSLVLESVWRTEAGSVHVLDFMPPRDG
                     APQVIRIVEGLTGEVSMISAMRPRPGYGSVSPWIHEVGGRMIAEAGADALWLDTCVPQV
                     EKDGVMVSVFSVAAGQSVAFVLSWCPSHAAAPDVPDPEAALTETLTFWQDWTRDCTYEG
                     PYRGAVVRSLIALKAMTYEPSGGIVAAPTTSLPEEIGGNRNWDYRFTWLRDASTTLAAL
                     LGTGYRQEAQAWRRWLLRAVAGDPENLQIMYGITGERDLRERELSWLPGYEGSTPVRVG
                     NGAADQLQLDVYGEVIETLYLAHESGVAHCAATAVLHQRLIENLAQRWQEPDEGIWEIR
                     GARRHFVHSKVMAWVAVDRTIRLTEAGALHIDVAPLIELRATIHHEVCTKGFDPVRNTF
                     TQSYGSRELDAATLLIPRVGFLPPDDPRVIGTVDAVRRELSSPDGLVRRYPTIGDRTGV
                     DGLKGDEGTFVLCSFWLVDALALIGRLDEAHALFERLLALRNDLGLLAEEYDPVQQRQL
                     GNFPQAFSHMGLIQSARLLQLLSTHSSHHRSAVAVPTPRSAPRSTRQTCADLTPQHA"
     misc_feature    24981..24994
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     misc_feature    25129..25143
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.9"
                     /tool="antismash"
ORIGIN
        1 gcacgggtcg cccgcacagg tatcgggtca ccgctgagtg gcagtcgcgg gaatctccat
       61 ccaggccagc ggcaggctcg ttctggtcag ggcgctgttt gactggtggg gcgagagtgc
      121 cggggggccg gctgccggag cacgtccagg tccgcgacga cgcggtcggc gttgtggagt
      181 ggaacacgcg ggccggaccc ccaccacgag cgcatagggg cggctccgct gcccttagcg
      241 agggatccgt ccgggtggcg gacgggcagg cccaagagct gctgttctat ggaggtcaga
      301 gcggggtccg ctcgaacggc ggccacggga gtgaggagta gcgctgagat tgatcatggc
      361 cgggagctgc ttcgattggg tccgcagcag ccgatggcat gatccgattc cttcggggca
      421 ggcgaggggg tgccgtctgt tcgcccccaa ctcgttggac gagttcgcca tgccctgaag
      481 ctggcgggct tccatatcgt cgatgaggcg gacgacgccg cgccggggct gagagtgggc
      541 gaggcgtccg cggtctgggt cggggacagc tcgatgccgg tgacgcgcgc cccgtgcgcc
      601 tgagcgagat ggacggcgtg gtggccggct ccggagccga tgtccaggac gcggcggccg
      661 gtgacgtcgc cgaggacttc tgctcccggt ccgatccctt cccagggcgt ccagccgagc
      721 cgttcgggga cgcgtggggt gtaaggcacg ggtcagttgg cgccggccgt agatctgcca
      781 ggcccgggtg ttggtgtcct cggcgggcac agttgcctcc tggtgggcgg gtgttcaggg
      841 gtcaggtgtg cgtgatcagg taggcggggc cctcgccgcg ccgggctcgt tcgatggcgt
      901 cgaggcgggc gaaggcgcgc ggcgccatca gctcctgcca ggtcgcgagg tcgtggacgg
      961 cccacatgtc gtgttccgcg ggatcgaggc ggatccgacc gagctgctcg gcggtcagcc
     1021 gccctccgtc gaagatgagc cccatcttgt tcagcggcag ccggggcccg gcgtgcagga
     1081 agtgcgtcag gagcaggatc ggtgcattga gggcgagttc gagtccggtc tcctcgaccg
     1141 cctcccgccg ggcggtctgc agcgggtcct cgcctagcgc gtccaggttg ccacccggga
     1201 actgccagag tctcgagccg tagaccgagc ggagctggac cggccggtca tgctcgtcgc
     1261 ggatgtacag gcagccgtac accgtgtggt gggggacggt ctgcgcgtac tcctcggccg
     1321 tcatcggcat ggggcggccg ggccgggcag ggcggtggcc gaaagcgagg gcgagaacgc
     1381 cgagggcttc cttggccgac gggtagatgc cgcggaggtt ggcgagcagc tcgccgggcg
     1441 gcccgtccgg gtcgatgcgc gcggcgtcct ccgagtggag cagatcctcg aaggaggggt
     1501 acggggtgat ccgctgcacg aggacgtcga gttcccgccc ggtatcccgg tcgtggaaga
     1561 cgaccgtgtc gccgacgatg atgtcgcgct tgtgcggggt ggccaccctt acttcgatcg
     1621 tcttgcgccc tgcttccact tggcggtagt accgcccgag caggtgcatg tggtgctcgt
     1681 gtggttcgtc tccagccgac gggttcggga cggctgggag cgcctgctca ggcatacatg
     1741 cctccgttcg atgttttccg accgtcgcgg tcgtgggagc gcgaccggcc atggagcggt
     1801 ggccgcgctc ctgtgtctcc ggatcggagt gggtggcgag gaagtggacg agtccgccgg
     1861 cgcgctaagg cagctcgatc ggtccgtagc gcgcgtgcgg ctcctgccgc atcagcgcgt
     1921 cgtaccggtc cgctaccgag aagtgccaga actcggtccc atagttcgta aaacccgcgc
     1981 cctccatggc gttgagcagc agcgtgcgat ggcggcgcgc gtgatcgctg aggtccggag
     2041 cgtgcgtgaa gcaggcgccg ccgctctcct ccggggaggc attgacacgg gtgccgagat
     2101 cgagttcgtg gccgtcctgg tcgacgaggg tcacgtccac ggccgcgccc gcggagtgag
     2161 gcgcgatctc cggcggcgac acgtaccggc tggcggcctg atgcagctgc tcagctgtcc
     2221 agccgggctg agcagcggcc agctggttcc ggtactcggt gaagtagagc tgctggaggg
     2281 aaagcggccg gtagccctcg atgaacagca ggtcggtgcc ggcgggcagg agcgagcggg
     2341 cgtgctgcag ccgggccagg acgccctcgc ggacgtgggc gaacgcgccc agcggatcct
     2401 gcttgcgggg atcgacacgg aagtcgtggt cacggaggtc gacgagcggc tccccgctct
     2461 cgcgcaccgg gaccgcggcg acccgcggat cggacatcaa caccagaggg ttcatcgagt
     2521 ctccctgtga cagcttgcac tgcggtggtg ggacggggga ggcagaagcc agatcggttt
     2581 cgcgcaccat tcgcgcgacg gtgtcctgca gcgtgctgtc ggccgggatc acggtctcca
     2641 gaccgccggg caggagatcc atctcgcggt accaggaggt gaggtggctg tcggtgacct
     2701 gcgccaggta cgcggcgtcc gccttcgacg cgtgccggac gaacgtcgcc tccagcggca
     2761 cgtccaggta gtagcagcgg gagacgccgc ggtggtcacg gaccagagac gtgatcatgt
     2821 ggctgtagcg gtcggcgtac aggatccctt cgagcaccac gtgaaagccg gcgttcagtg
     2881 cgtcgcgtgc gatcctgctc agcagggcga tgttggcgcc gcgcgcggtg tcgtgttccc
     2941 tgagcacgtt ccggcggatt aggtactggc ccacgatcgc gacaccgcgg ccgtggtgat
     3001 ctcgcagccc ctgggccaca ctcgacttgc ctgacgccga gttgccgcgg atcaccacga
     3061 ggcgggtgtc ctcacgtccg gccgcggtcg cagtcgacac gcgacggtgt gcgcggttcg
     3121 ttgtgccggt catgcgggcc aacccgtctc gctgtacagc tccccgttct ggatctttct
     3181 gatggccacc cgggtgtagg agacgaggtc gtcggggagc gcggcagggt cccagaattt
     3241 ccactcggtg cacttgtccg gctcgcgcag ctccggctcg ccgctccagg cgcgggcgcg
     3301 gaagaacagg cccatgcggg gccggtctcc ggccttgtcg atgtggtgga cgacgtggac
     3361 gagttcgacg tcctggcgct ggatgcgtag gccggcttcc tcccgtgcct cccggatcag
     3421 gcaggcgatg gcgttctcct gctcgcaatg gccagctagg gcgtgccagg tggacggcgc
     3481 gaacttggag ttggggtggc gcagcccgag cagcaccgtc ccgtcggggc gctccaggta
     3541 gaggtggacg ccgatgacgt taaggaccgt gccgttcggc gaagccgggc gacgctcctc
     3601 gggcgagggg agcccgctct gcgaagtggt gctggctggg cggccggcgg catggcgccg
     3661 tacgaggtcg ctcgtggtgt cggcgatacg gaggcggtgg aggtcgtccg gggcgaacca
     3721 ggccagcatc accccttccg tcaggcggag tttgcgggga tcgccgttcc agcggcccgc
     3781 gtagatggcg atgggcacga ccgcgccggc ctcgtcggag gcgtactcgg tgccgaacgg
     3841 ggtcagatcg gcgatatcga ggccggcttc ctcggccagt tcgcgccgca ccgtgtgttc
     3901 cagggtggcg tcctgggact ctcggccgcc gcccagcagg gaccacatgc ccggctccca
     3961 gatctcgccg ggaaagtagt cgcgcaggtg gagcaggtac tcgccgcggt cgttgtagat
     4021 cagggcggag gcgttggccg tctccggttc gacctggagc gggagcttga ggagcttctc
     4081 gcgcagggaa ggggaggccg ccctgtccac gggccgccac tcgatgccgc cgacctcctc
     4141 ttcctgcagc atcacctcca cctcgttcgc ggtgtgcagg cggaagagga accggagttc
     4201 gaagtgctgg tggccgggtt cgtctttgcc cgggttggcg tcgatgtggt ggatgtcgat
     4261 gtcgaacggc accgtctcat agccgggcca cggcgtgact gcctggggcg ggatcccggt
     4321 ctcctcgtgc agctcccgca gcgccgctgc tgccagggac tggtcggtgg gctcggtgtg
     4381 tccgccaggg gcgaggacct tcccgctcgc caggtgcagc ccgtgcagga cgcggccgag
     4441 tgggtcgatg acgattgcgc cgcaggtgac gtgtccggtg aacgtggagc ggcttgcgat
     4501 ctcgtcgccg gtccggttga gggcatccag tagtccgccg agctgctcgc gctcgtgagg
     4561 gtggcgagcg aggtaagcat cgacagtggt gcggatgtgg tcgtgcgaca acggcatggg
     4621 gctacctcag agggcgtgga gcgggaggag tcgaggtggg ggtgggcggg tcgggtcagc
     4681 tcagccgcat cccctccgac gggatctcct cgacggcggc ggtgcgagcg atgggcagcc
     4741 cccaccactt gcgtgccgtc tccgccgcga gctgggcttg ccgcgctccc ggcgggcccc
     4801 atcccagcag cgcggctgcc tgggcgggcg tgacgagcag gcgggcgaag gggtggccgg
     4861 tggcgcggtc gacggccgcc gggccgacgg cggtgacccg ggcggctagg cggaccctcg
     4921 cgttgggccc cacgccgccg tagacctcgc ccgtctcgtc cagcacccag cccagtcgta
     4981 ccggatcggc cagggtgagc tgagcctcct cggcagcttc gcggtacagg gtgtcctcgg
     5041 gagtcgcgtc ggtcgtctcc acggtgccgc cgggcagcat caccagcagg acccgtccga
     5101 cctcgtcggt gatgatcgcg gcggcgccaa tccacgccgc atgccgggac acggcgtact
     5161 gcgccgccgg cgcagcggca cgcggtgtga cgtgatccga aggggagacg ggagagggca
     5221 cgtatctctg cctttcgcga cggtggacgg gcgagcgcgc agcaaggagg agcaagcggt
     5281 ggccaggagg caccgccgtt catccggcgt cgcagctccc agggctggtg gggccggcag
     5341 cgctgccggg cacgatcggc cagtccacgg tgatgcgggt gtgcttcttg gcgaacacgt
     5401 gcggttcgtg gtccgtgcct gccggggcgg ggtcagctgc agggcgggcg gtgatgaggg
     5461 ggcagcgggc gccacggtgg ttgagctgcc agtgctggac ctgctcggcc atctcctgcg
     5521 cggaaccgtg tccttggtcg ccgtagccgt ggacgacgaa ttcgtaccgg cccttgccgt
     5581 cgtccccctc gccgatgcgc tcggtggcca gccgggcgag ggagcccccg cgcacgatcg
     5641 cggcggcggg ccagtgcctc agcggcgggt tgaggacctt gttgtcgccc tcggagtcgg
     5701 cctccaggcg gcagaagcca ggcagggcac cggcgaggta gagggtgagg gcgtcgaagg
     5761 gttcctgtcc gccgacagtg acgttggtgc gggtgacggt cggctcgcgg gtgagggcgg
     5821 aggcgagttg gtcgacgggc agcggggtgc cgtcttccca agacaggtgg acgccggtgc
     5881 cggggacggt gcggcggttc gtgttccagg cgccgtcgcc ctgcatggcg acaaagccgc
     5941 agatgatgag cggctcgtcg ctgtgcaggg ccccctcctt cctggtgaat ccgatggccc
     6001 agtggtagcc gtgcagacgc agcggtgcga cgagacggcc tccctcggcc agggcgtcga
     6061 tccagggcag gtcccaggtg tcgacggtga ccagaatggc gtcgaagccg ccgtccggaa
     6121 ccacaccggc gggcaggtgc tcggcgtccg cggtgaccac gctcacgtgg tcgtatccgg
     6181 cctggggcag gaagcgaagg gccctgtcag tgacggcggg gtcgatgtcg agggtggtga
     6241 tgtgaccggt cggaccgacg agttgggcga gtagggcggc gttgcagcca ccggagccga
     6301 tctccagaac gcggtggccg gcctggatgc gggcggcttc gagcatctcg gcctgcaacc
     6361 agggcgcgga aatggagctg gtgacccggc cgtcgtcgct gtgtcgagtc gggacgatgt
     6421 cgttggcgta cgcagcgggg agggggatct cgggggcaaa ggcgtgcctg ggcacggtgc
     6481 ggaaggcgcg ctcgactgcg gcggagcgga tatggctgcc ggcgcggagc tgctcaacga
     6541 gctggtggcg aagctcgctc gcgtcgctga cttcagtagc tggcgaagtc gtcacggcat
     6601 tccttcccgg gttgatcggg cggttggaac gtggtgcgaa gggagcatca ggagcgggcc
     6661 ggtatctctg ctccggcaga ccggtggttc tggcgcgggc ccggtgatca cggggtgtcc
     6721 ccgctcatcc ggcgctgcag ctcccacagg gtccggaaca gccctggctg ctgggtgagc
     6781 tgggcgtagg tgccctcctg gacgatccgc ccttcgttca acaccacgat ccggtcggcg
     6841 acggcgacgt tggtgaggcg gtgcgtgatc agcaggacgg cgcggtcctt ggccagttcg
     6901 cgcagaccgg cgaagatccg gtgctcggcc cgggcgtcga gggcggccgt gggctcgtcc
     6961 atcaccagta gcgccgcctg ccggtggaac gcgcgggtga ggaccagacg ctgccactgc
     7021 ccgcccgaga gctgctgccc gccgaaccac tcgctggtca ggagggtgtt caggccggag
     7081 cggaggaccg gcagcatctc cgcggcgccg gacgcctcgc aggcggctag cagggccgcg
     7141 tcgctggtgt cgccctggcc gaaggtgatg ttgtcgcgca tcgtcagcgg caggtaggtg
     7201 aatttctgcg ggaccagcgc gacgtgcttc cacgaccccc acgggtccag gtccgcggtg
     7261 gatgcgtggt cccaggccac gtcgccttcg gtgggcagca gcagcccgca cagcaggcgg
     7321 gagagggtcg tcttgccgga gccgttctcc ccgaccaacg ccacgatctc gccgcgtcgc
     7381 acgtggaggg agacgcagct caggctgtcc ttcggggcgc cgtcgtagcg gtaggtgacg
     7441 tcgcggacct cgaagcgctc cggggccgcg ggtacgggag cggtgccgcg ggagtcggtc
     7501 atggcctggc cgtgggcgtt gtcgaggaag ttctgccagt cctgcacgta ccagccggtg
     7561 cgcaccaggc gggccccgcc gttgatgatg ccgcgcaccg agccggtggc ggtctggaga
     7621 gcgaagacgg ctccgccgcc agccgccagg ctcatgcgcc cggaggccag gagccacagc
     7681 agcgccgccc acaccgcggt cgaggcgatt ccgccagcca cggctccggc cagtcccatc
     7741 caggcaccgg tgtttgcggc cttgcgttcg gccgcgttga ccgaggcggc cagcttccga
     7801 tagcggccga tcaggaaggg accggccagg caggcgcgca tctcctcgct ggattccatg
     7861 taggccatgt gccagcgcag tttgcccagc atccggcgcc gcccggaggt ctccagagcg
     7921 gcgaggtaga gcacgcgtgc ggagcggatg taggcggcgg cttgcggcag gcacgcgagg
     7981 aagagaaggg gaaggagcag cgggtgtagg acggtcagga cggtggcgcc ggccgtgagc
     8041 gtggcggtcg ccgcgaggac gtcctgcgct tcttcgacga ggtcgggggt gacctgggcg
     8101 ccgcggtcgg cgatgtcgta ggcgtcgttg tagccaggct tgttgttggc ggccaattcc
     8161 gcgcccagcg cggcctcaat catcgtcagc tccgcggccc ggccgagcac cgggcgtaga
     8221 cggccggtca gccagacgac ggcgatgccc aacagtgcgc gcagaccggt ggcggcggcg
     8281 atcacagcca gctgcggggc ggcgtcccac agccgctcgg tgatgtcgcc cgaggagatc
     8341 agcgcggtga tcgtgcccgt gacggccagg aggcccaggg ccgcgaggac gccggtcccg
     8401 atctggcaca ccagcaggcc gatggtcgcg ccgcggtcta cgcgccaggc catctgcacc
     8461 gagcgccgca cgagggaggg aaggcgccgc gccatggtgc gggaagtcag cagagagcca
     8521 gcctggagcc gtgactcgtc gcggtagagg tactcctcct ctcgaacact ggcctcctgc
     8581 gcttcttggt ccggcgcggt ccccttgggc ggttgcggcg gctggtcccg cgtaatggcc
     8641 gaggtcatcg ttccccctag gacggtcgct gcggcagagt cgtgaggtct aacgacgcgg
     8701 ctgcgatatc gaacacacgt cattcggtcg tgctcaggag cccgcaattt cctgcgtcag
     8761 cggaccccgc gggcgcggga tccctgctct ggcctggaac ggctgtgggc aggtaatggc
     8821 cgaaacgccg acaccgccaa acagcgtggg cagtacggcg gggcgtccca gggcgtcccg
     8881 cttctagcgg ggatctggtt cggcctgcag cagcctttcc agctctgtct cggcgcggcc
     8941 gaccgcgctc gccaaagcct catggtgttg ggcggacagg aagccggatc ccagtccggc
     9001 cgcgacgatc accgcgtgga gcgcgtctgt cgccccgccg tccaaggcgg acgcggcgac
     9061 ggggtggcgc agtgcgtctc gtgcggcgta ggcgtcgagt cgggcgacgc tgacgaggga
     9121 gtcgagtacg cggtcggaat ggcgtcccgt gccgtccagc tccagggctg acaggcccgt
     9181 ccgggtctgg aaggcggcgg tcggcggatc ggggtgggca aggagctgga cggcttcatc
     9241 catggtgcgg tcgaggtcgg gttcggggac gggggcgtgt gcgggctggc agtgggcgtg
     9301 caggaggagg gcgatggctc tctcccaagg ctctgcgggc tgggtggtgt cgatcaggtc
     9361 gcgggcttgc tggtccaggc cctgctccat cagcgccatg atcttgatct ggcggccgtc
     9421 gaggagccgg ttgccgatgc cgcggtgctg ggccatggcg tcggcggcct cgctccaccg
     9481 cccgatgcgg gcgagtgcgc gggcgccgtc gacgagcagc gtgacgtaca gctcctggca
     9541 caccgtgcgg tggtcctcgt ccgtgccggt cagagcagag aggtcgacgg tgcggccgtc
     9601 gatgtcggtc ttgttccgat gtcgggcagc gtcgttgagg cagtacaaca agccgtaagc
     9661 gagttcgccg tggccggcgc gagtctgcag gcgggagagg ttgacgagcg gcatcagcga
     9721 catgacggcg acccgtccgc tgaggcgtcc ggcgttggcg aagacctggt gctggcgcca
     9781 gcacagatcc tcggctagat cgggcaggcc gacgtcggag gcgatgagcg cggcgtagtt
     9841 gaggaccccg caggcgcggg ccaccaggtc gtggtggctc gcacctgcgg gcgcgacggt
     9901 cagcccggtg aggtggttga tgcgctcctc caacgggagc gcgggcgcct tggtgcgggg
     9961 gaccagggga atgcggctgg ccatcgcggg gatcatcggc tcagcccttg cgcgcccagt
    10021 cgacgaccag tcggctgtag ggcttgtcga cgacgaagcg cgggtcgtcc gccgtcagcc
    10081 gggtacgcga gtcggcgacg gccatccgga agcccggttc gggggcgttg ttgccgccgg
    10141 tcgcgtccca ggcgcggatc tcgctcacga cacgctcggc gatgtcggcg cgaccctcgc
    10201 cgtggccgat cacaccgacc tcccagtacc ggccctgctt gtcctcgccc tcccggatgg
    10261 tcaggtacgc cagcgacccg ccgtcgaggg cggccatgga accccacccg aagtgtgggg
    10321 tgaacccggg gcgctgcccc ggcagccggg acaggccgtt gggcagcacg caggccaggt
    10381 acaggtacag ccactcccac gccgagccct gccggaactt cactccggtg tagatcttgg
    10441 tctgctgctc gtcgaggacg gagcgcaggg cctcgcggtc gacgtcctgc tcgctgaacg
    10501 tctccaggcg cacgttgccc tccccggcca tcggcacgag ggtgtacacg tcgtcgcaga
    10561 cgcccttgcg gagcgggatg aaggtggcca tctcgcagga gacggtcttc cacgtgtcgc
    10621 cgtcgcgttc gaaggcgaag gagcgggaga tgctgccgcg gatgcgcatc ggcaggacca
    10681 ggcgcccgcc gggggcgagc tggtcaagga tcttcacggg gacgtcgccg gcgccgacgg
    10741 tgaagatgat ccggtcgtag ggggcgtgct cgggcagccc ggccgcgccg tcagccatca
    10801 ccgcggtggc gttgtcgaca ccggctttgg cgaggtgctt gctcgcgccg gcgacgaggt
    10861 cctggtcgac gtcgagggtc cacacctgcc cgccgggcga gacgatcttg ccgaggaggg
    10921 cggcgttgta gccggtggcg gctccggctt ccaggacctt gtgaccgggc tgggcgccga
    10981 gctgttcgag ctgggtggcg acgatggacg gcgcggagat gcaggagatc atctccccgt
    11041 gttcgtcgtg cttgatcggg accgcgtcct ccttgtacgc gctctccagg tcgacgccgg
    11101 gcaggaaggc gtgccggtcg gtgctgcgga aggcgtcgat ggccgcctgg ctgctcaggt
    11161 ggccgctgtc gacgagccgc tgggcgaggg cttcgcgcag ctgcttgggg tcggttacgg
    11221 gtgtcacggt ggtctccatc cgagggaggc tagggtccgc ggaggcggac ttgcgggtag
    11281 acacgtcagc tccttctccg gtggaaaagg cgacgtgacg gccgagccac gcggtggcgg
    11341 cctgcacgtc ggcaggcacg cccgcacggt tgaacgcgaa gatcgcgtga tgggcgatga
    11401 cagcccggat tccgcgtatc agtcggccgt ctgcggcgag tcggcgcagg cggcggccgg
    11461 cgtcctcgaa ctcggcgacg cgctcgaccc agcccgcttc cgcgtctggg cgcagggccg
    11521 cgtccgcgtt catcagccgc cgcatcgcgg agacggcttg gtccagtgcg ggcccctgag
    11581 gcggggtgac ggggggccgc agggcggccc accggcccca tacgtctccg gcttcgaagg
    11641 ggtccagtcc cgccgcgcgg atcatggcgg acagcagcat cacgctgcgc tcgcgggcgc
    11701 cgggggtgcc agtctcggcg agcgcggccg ggctgtcggc gcagaacacg tcgtgcgcga
    11761 cctccatgcc ctcggggccg ccgaaggcgt gcgtctccgg ctcgtagatc ccgcccaccc
    11821 agccggtgat cacgcggtcg gcgacgagct ggtccagcaa gtcggcgacg ggctgttcgg
    11881 tacgcaggcg cacgccggcg tccttgcgca ggaagtggaa gcggcgttcg cccagcgcgg
    11941 tcgccagggc cggggcggcg tccgcgtgcg ggtcgggaaa ggccacggag gcgtgccacc
    12001 aggacgtgtc cggggggacg ggcaggttct cttcgtcgag ggtcatgagg agggaactcc
    12061 ttgcgagacg gcggggtggg tcaggtgagc agcaggacgc gggtccaacc ggtggcgtcg
    12121 gtggccttca gggcaagttg ggccccggcg cggccttcca tgaatccggg tttgggcagg
    12181 tgctcccagt cggcggccag ccgtcggtgc aggtcctgga tgatcggggt gaagcgttcg
    12241 gggctggtgc tgtcggcggc gaccgcgcgg gtgagagtca gcagcccggc ccagccgtgg
    12301 cagagcgtcg agtcggtgat ccgggcgagc cgcagcgggt cggtcaggat cgcctcgacg
    12361 gtgtcctcgg ccgcttggcg ccgtacaggg tcgccgaggg caagcgcggc gagctgctgg
    12421 gcgcgggcga tgccgggctg gccgtagcac caggactggc gggccggctc agctgggggc
    12481 ggctggtcgg cgtccaggtg ggctgtggtg gaccagtagt ggtcgccgtg ccggtcgagc
    12541 caggtcgcga acgtgtcgac ggcctcctcc tggccgggga cgctgactcc ggcgcgcagt
    12601 gcgagggaga gcacggccag gggccccgcg atgccgtggg ccatgccgtt gttgccgtgc
    12661 ccgcctgcca tgtccttccc gtcggggccg accggcgacc accacccggg caggattctg
    12721 ccgtcactgc gggcggggtg tgcgagcgcg acgaggcaag cgagcacgtc gggcagccgg
    12781 ggcgcgatcg ggcggcggga cagcagcagt gcggcgagcc cggtcatgcc gcggatgagg
    12841 tcccattcgg cgaggtgggg cagcgcgccg gcctcctgcc ggcggtgggc ggcggcgagc
    12901 cgggcgtcca cgacgcggtc gacggccgcg cggacgtcgt ttgcggcccc gtgggcgcgg
    12961 tccaggacga actccagggc gggtgcgccg tggaagaggc tggcgttgct gccggtgctg
    13021 acgccccgga cggtggcctg ggcgaggtgg cggcgggcgg tggacaggtc acggcgctcg
    13081 atgtcgagca gggccatccc cagggcgccc tcggacaggt cctgcgtacg gggcacggtc
    13141 gtcgtggtca tgagcgcctg gccaggggga cgacgatgct gtgggcccgg ccgccgatcc
    13201 acccgtcggc gtccggcggg ggcgcgtcgt gcagggtggc gatgccgagg gggctggcgt
    13261 ccaggtgcgc gcgcaggagg tccaggtcga cgtcgcgggt gaggtcgagg ggcagctgct
    13321 ggtcgtcctc ggcgagcagg acccgatccg gcacgcggaa ccgggcacgc caggcatgga
    13381 gttggtccgc ccactgctgg aatcgggcgg tgcgggcagg cagcgtacgg ctgcggatct
    13441 tccaccgggt ggtggtgagg atggtgcgac ggtaggtgag tgccggggtg aagggcaggg
    13501 tccaggcggc gccccagtcg aaccaggtca cctgtgggga cgcggcccgg ctgatctcgc
    13561 cgaggaagcg ggccatcggc ggggtgtagt tgttccacag gaagttgatg gcggtggggg
    13621 ccagcagctc cagcggcttg cccgtcgcgg actccaccag ctgggggcgg ccgtccgcga
    13681 cggtgaccgc caggtcgcgt gggaagagca cgtgcggttc gggacggcgg aattcgccga
    13741 cgctgacgat ccggggcagg gcctgtggtg cgcgggtgag caggtcggcc ggcacccgcc
    13801 cggcgtggaa ggagagctgc gcgagttccg cctccggatc gacggtgggc agcttcgcgt
    13861 acgccgtctc ggtgccgggc aggaggtgcc agaaccgacc ggtcatcgat ccggctgagc
    13921 gggagacggt cagaacgtgc agccggaagt cgcctcggtc cagggccgga agagaggagg
    13981 cgtggacctg cgcggccagt tcgaggtggg gtgccagggc ctggggcttg tcgccggccg
    14041 ctgcttccag ttcctcgatc atcgccccgg tcagcgcgac ggtgcggctg ccttcggcgg
    14101 ctgcggtacc agccagctcc agcagcaggc ggtcgcgtcg ggacatcggc cggggcggtt
    14161 cgctcgccgt gacgaaccct gccgggaagc ccacgccccg gtcggggtca gtcaccgctt
    14221 ccactggcac tgcggtgttc tcgccgtagc gctcggagaa ctgctcgatc caccggcgcc
    14281 aggtcggtgt cccgttcgga tgggtaacca ggcgggccag gatggtggcc gcggtctccg
    14341 attcggtcag cacctgcttg ggcagccgca cgtcggcgtc cagccgcagg tcgcatgctg
    14401 tccgcaggcc ggctgcctgg gtgtgcgttg caggcggtaa gacgtcggtg gggtcggcga
    14461 tggtggcggg ggcgcgcagg gaggagcgca gcagccgcac ccgcagcagt tcacccagca
    14521 gccggtcgcg cgccgtgtcg ctcacggcgg ggaactccgc ggccagtttg tcggacaact
    14581 ggcggtacgt gatcggtgat cgcgcgaggt cgagtacgag acgcagcgcg gggctgaggg
    14641 ccaggcggaa ctcggcatcg ccctcggacg gtacgtggat gtgctggtcg cgctgtcgga
    14701 tcagggtgtt gacgcagacc tcggcgtcgg ccatgcgcgc agcgtcgctc tcccaggcac
    14761 tgagtatctc ttcgagcccc accgggtcgg ggcgggtgac cgcctggtgc ttctcaccga
    14821 agcgcacgga cgtggcctgg gcgaagccga gcggggcgac gccggcgaac aggccgtagg
    14881 gggtggagcg gcgggcgtag cggatcgcgt agcgggcggt ggccagcgcc gcccggcgca
    14941 tccggcgcac cttcggtgtg cggccgtcga tgacggcctg gacttggtcc gccaggtgag
    15001 ggctcgcctg cgacacggcc cggcggaagt cggtgtcgga ccacaccgtg ctcagccacg
    15061 cgcgccactc gtccacgggc gctttggcca ccggccaggg cggcatggcg ggctcggtcg
    15121 tgtgcaccgc ggcgcgcagc atggcctgcc ccgcggcctc atacaggctg ggccggtgcc
    15181 gtgtcatcag ggctctcctc atcttctgcg tggtgggcgg ggtgggccgg acggggagag
    15241 ccccgtccgg cccgcgttgc cggggtgtcc cgacttacga ggtggtgcag gcgctggggc
    15301 aggagctgcc gcaggtgtcg cccgtgctgc acatcaggac cgtctcggtc gccggcgtgc
    15361 cctcgatgaa ggtgatgtcg agtccgaacg ggtcggtctc gtcggtggtt gccaggtccg
    15421 actgcacggg ggcggtcggc ctctccgtct gcacggcggt catgcttgcc tcctaggggc
    15481 gatgggtggt gcgggatccc gggacccggt cggggcccgg agcttggtgc cagacggtgg
    15541 caggcgaagg cgtcgcctgg tccaggacgt ctgggagtcg acgggacccg tgccgtcagg
    15601 ctgctacggg ctgcgcttcc tggtgggcct tcgcggcctg gttcaggacc ttggtgaagt
    15661 gctcggcgcg ttcgtcgccc tcggcctcct gggcgcggag gtctccgaaa cgggcccagt
    15721 agcgccggca gacgtcgctg ttcatgagca tcgaggcgta gaagggcagt tgtccgtcgc
    15781 ggacgaagcc caggcggtcg cgcaggctga gggtgcagat ctgctggttg gcatggagca
    15841 gctgcatgta ctcctcgacg tccatgtcct cgggcgccca gagtttggcg aggtcggcgt
    15901 tggtggacat ctgcgccagc cagtcgagct ggttgcgggc gacgaccgcc tcgttgcgct
    15961 cggcctggtg ccgcgcgacc tccctgagcc ggacggctcc gaccacggcc gtggtgaggg
    16021 agacggcagc accggcagcg aggacggctg tggtgagctt catctgtcaa cgatcctttc
    16081 gcagagcgga gttgcggccg ggaggccggc tggtggagaa gctggggtcc ccctgcttca
    16141 cgcggccccc gcgaggacga cggtcggggc ttcatcggca gagccatgcg cggtgtaccg
    16201 gcggcgcacc gccttcagag cgacagcgat cggcggcaga cccacggtgg ccctgcgtgc
    16261 gtcgactgac tccggcccgc gcagcgggca caactcgatg ccgtcggcgc acagcaggag
    16321 ctgggtgccg tactcctggt cgcgcccgct ggtgatgagg gcgcgctcgt gcaggtgtgc
    16381 ccagtgctgg accagcgcgt cgccggcctg gaccgcacgt cccagcaggg tggtggcggc
    16441 gcgccggaag tcgggttcgt cgtcgctgtg cagggcgatg ctccacgcgg cacgggccgc
    16501 gtcggggccg acgaggcggt ggccgggcca gtcgtggtcg gccaggatgc ggcgcagcac
    16561 cttggtgttg acgtggtcgg tgtgccggcc ctgtccgagt tggacggcgt cgagctggtc
    16621 gcgcacgcgc ttggcccggt gcgtggccga ttccgtggcg cgggcgatgc tcgcgggcga
    16681 ggtcgggccg ctgcggttcg tcagttgtca cgcgttgctc cgatcatccg gagccggctg
    16741 aggcgcgtgg acctggcagc tgatcagcgc gcggagcccg gcgcggtgct cgacggggag
    16801 ttcgaggcgg gcgactcgat cgccgtcgcg tccggggccg gatccgcaca cgtcccagcc
    16861 gttgtcggtg agccgacgca ggagggcagc gaggggttcg gcttcgagag tgtggcgggc
    16921 cagcgtctcg gcccgtacga cttggaggtc gagtcgggcg gcgaagtcgg acgcccacag
    16981 ggtgatcagg cgggtgatgt catcggactg gccgggcagg gtgtggacgc tttggaggaa
    17041 gaggcacgga ccctggcccc atccgaggtc ggggtcacgc tcggggatca tgcaggccag
    17101 cagctttccg tcctcgtaca gtccggcgga catggtctgc gcctcgctga agagtgccgg
    17161 gatgtcggcg cgggcgggta cgggcaggcc gtgcattgtg agccagcgct ggcggtcctg
    17221 gacgagggcc gcagcttcct cgcgctcggc cgccgtgcgc agcatgcgca tctcgtagat
    17281 ggcggtcggc ggcgtctgcg tgaaggggac ggaggcggag cggtactcgc tggccgctga
    17341 ggtcgtaggc cgggtcactg gcttgccccg tttcgcgtcg cgtgggctgc ttgctcggcc
    17401 ggcagcagct gccagccgtg cgccaggacc accagttcgg tggtgtcctg tgcgcccgtg
    17461 tcggcgagga gctggtcgag cgcggcgcgc tggtcggccg gggcgagctt ggcggcgacg
    17521 gcgatgtcgc gcgtatcgct gtgctcagcg acggctcgca acagcagcag ctgctcgggg
    17581 ctgagcttcg gagctggcct gtccgccgtg ggagaggcca cctgctgggt ggtgaacagg
    17641 cggtgcacga tgacgggggg cttgcagcgg ggcgggcagt ggaggctcgc gcggatgtcg
    17701 cggatgtact ggcggacggt gaccgcggag agccctgtct tcgcggcgat ctcttgggat
    17761 gcacagccgt tcgcgaggtg ttgggcgacg cgctgcagcg tcggcgtcag aggggtgatc
    17821 ggtgcgctgg tcgtcacggg cggggtcacg gtgtctcttt ctcggctgga acggacggtc
    17881 accggggtgg gtgccgccgg tccccgcggg ggacggggac cggcggcacc ggcccgtgcg
    17941 cggtggtcgg gactcacggg gtgccgcgta cgggggctca tgcggcggtc gggtcggggc
    18001 gtgcccaggc ggcttcggcg gcgaggcgtt cggaccactg gatgtggttc tcgtcgaagg
    18061 cggcgtcggc caggtgtaag cgctggacct cgccggttcc ggcgggcggg taggtgtgct
    18121 ggatgtcgcg ccacaagcgc tggaggacgt agtcgcggtc gaaggcgtgg gcgccgtgca
    18181 gttccatggc gtcctgggcc gactgcgcgg cccactggtg gccgaggtac ttggcgttga
    18241 tcaggtcggc gtcgcagggc aggccctggt cgagaaggtg cacggactgg taggcgagta
    18301 tccggccggc gcgcagacgg gcctccatgc caccgatgcg gtcccgcagt acgggcaggt
    18361 cggacaggct gccccgatag cgaggacggg tcttgagacg agcagtggtg gcggccacga
    18421 ccgcttcgtg aatgccgagg ctcacggcgg ccaggttggg acggccgtac agaatgctgc
    18481 tgctctgggc cacgctcagc cctcgaccga tctctccgac cacgttgtcc tcgggaacac
    18541 ggacgtgatc gaggtcgagt cggccggcgg agaagccgtg cagaccgagg ccggggcggt
    18601 gctcggggac cgagagcccg cggcggcttg attcgaccat gaacgcggtc agcgcctggg
    18661 atgtgctcac gcccgcttcg gcggtgcggg cgacgacgag gtgggcaccg gcgaggtgac
    18721 tattgccgat atggaccttg ctgccggtga tcacccactc gctgccggcg cgttcggctg
    18781 tggtttcgat gccaccgatg tgtccaccgg cctgtggttc ggtcacggcg atcgatagca
    18841 gcagggaacc gtccgcgaca cggggcagcc agcggccctt ctgctcgtag gtggcgaagt
    18901 gcagcagggc gccgacgggg atcagggtgg cctgcaggat ggctgcggca gccgccgaga
    18961 tccgcgcgat gcggtggacc aggatggtct tggccacatg tccggcaccc agcccgccga
    19021 aggcggccgg gatggtgacg gcgaaccagc cccgtgcggc catcaggtcg gcgaccttgc
    19081 gctccaccct gcccggagcg gcctccatac gcgcggcgcg cggcgcgatg tgctcggccg
    19141 cgaaggcgtc cgcctcgtcc cacagcactt cgtggcgggc ggtgaggtag gggcgcagcg
    19201 ccggtggcgg tgtagtgggt gtggcggaca tggtctccct ctccctgggc gaaggtcgca
    19261 acgtggagcg gccggggatc gcctacggct cccgggtggg ggtggtggaa cggcctagcg
    19321 gacgggggcg cggaccatgt ggtccatcac ctgggcaccg gcgttgatga cgatgtccct
    19381 gagccgtcgg gcctcgctca gggggcgctt ctcggggtcg atgacgcaca ccgtgcccag
    19441 cacggtgccg ctgtcatgga cgagcggggc gccgaagtag gagcggatcc cgacggcgtc
    19501 gaccacgtgg ttgccgctga agcgcggact ggcgtgcacg tcgtgcagcg ggagagcctt
    19561 cttgcgggcc atgacctccg ggcaccagcc gtggtcgcgg ctcatggtgc ggccgacgat
    19621 gaagtacccg ctgtccgccg gcggctggtg cagcccgacg aaggtctgct cctccaggaa
    19681 gagattgacg aacccgtaca ggaacccggc cttggcggcc atgtcgcggg ccaggtcgtc
    19741 gaagtcctcg ctcgccacga gaggcacgcc caggcggttg agcagctcgt accgctgcgc
    19801 cagctccggt ggctgctggg tctgcggccc ggtgacggcg gtggcgggcg gggtgatcgg
    19861 cccgcaggcg gcgtcccgcg tgccgcgtcg cggcagggac agtgcgggtg gggcggtcgg
    19921 cgatgcgagg taggggttgg ggtgatgtga catcaggcgt cctggagggt ggtagtgggc
    19981 gtgtggtgaa cgcgggtcac ggaggcgttc ttcacggcgt ggccgacgag ggtcagcagg
    20041 acgccagcga cgtggttcgg gtcgcgggcg tcacaggtga tcaccggtac ggaggcaggg
    20101 agttcgaggg cagtgcggac ctgctcgggc tggtaacggt gcgctccgtc gaactggttg
    20161 atggcgacga tgaagggcag gccgatgtct tcgaagaagc tgatgggggt gaagctgctc
    20221 tccagacggc gggtgtcgac catgacgacc gccccgacgg cgccgcggga gagggcgtac
    20281 cagaggtcga cgaaccggtc ctggccgggc gtgccgaaca ggaacagttc caggggtacg
    20341 ggcgcgtcgg gcaggctgag gcggccgaag tcgaaggcga ccgtggtggt ctgcttcgcc
    20401 tcgatgcccg ccaggctgtc cacgtctgcg ctcgcctcgg tcaggtactc ctccgtgctc
    20461 agcggcgcaa tctcgctgac ggcgcctacg gcggtggtct tgcccgcgcc gaagcccccg
    20521 gcgatcacga ccttcagcac ggtcggcgcg gcgccgacgc gcgggtgcgg cgaagtacgc
    20581 agcaccgcgc ccgggtcatc cggcctgggg gtaggcgatg gcatcaggcc acttcctctt
    20641 caagcccgct gaaagggctg ccagcagttg ggtagacgga ccggattccg cgcccgtatc
    20701 ggcatagggg tgggtgaggg ggacgaccaa ggcgtcggcg tccaggaggt ccgagacgag
    20761 gatcttgacg gcggtgacgg gccggccaag tcgtcccgcc agttcgacca ccgatcgtcg
    20821 gcgctcccgg cacagggcga ggatctcctc gcattcctcg gcctgggccg ggccgggcct
    20881 tccccgtcct gcttccagca cggtttccag accgagcagg tgccgcggcc tggtccgccc
    20941 gcgcgtcagg gtgtaggtcc gcacgaacat cgactcctcg gtcgcgcggc cgtgtgtgct
    21001 caccggacct ctccgccagt gccgacgcgg accgggatca gcatgtaggg ggcgaacttc
    21061 tggacgaggc gccccatctc gaatccgacg gtgcccgcat cggcgtccgt ggttgcgatg
    21121 acggcgagga tcgtgtccac ctcaccgcgt tcgttgccgg ggtggttgtc gaaggccgcg
    21181 ctacgcccgg cgctttgaac gaagaagagg cagtcgtcgc gctcgatgat gacctgccgg
    21241 gccggcctct tcttgtggct ggggccggtg atgttcgccg cgagggaggc aactccgctg
    21301 agggcggccg acagttcgtc cgcccagtcc ttgtcgacgt cgctgtccaa cagccgcagt
    21361 ccgtcgcgcg acagcaggac ggcgtgcgtg acgcccggga cggcggaggc gaactgacgc
    21421 agcagccagg ccatgttgtc ccgctgtccg cttgcagttg tcccggttac gggcgcgtcg
    21481 ccggtcacgt tgtccatcgc ggggtgggtg ctcataggga tcgctccaga agggggaagg
    21541 gcccgtggag gtaacgggcc accgggaacg tcgagggacg ggggttcagg gcgcgggctg
    21601 ctctgccgaa gcggtggaag aaccggctct cccgccggcc tgaatgccgt ttcggaaggc
    21661 ggctgcgagc cctggcgtcg ccccggtcac gggggcttgc tcccgctcgc gcgatggacg
    21721 gaacgagccg gcctgacgtc tacgcgtggg aagagcgggc gcatcagcag agtgacccgc
    21781 ctctacggct ccttgtgccc ccacattgct ggggtgggtg acctggcctg ccgtcgggac
    21841 ggctggagca gcggcgacct gctgcggcgg agcggagggg cgggcttcct ggggtcgcgc
    21901 ggtcgcatcg tcgacagagg gaatcgctac caggaggcgt gtcgggatga cgacgagggc
    21961 ggtggtccct cctgttacgt tctcctgcag gagaacggac agcccgtgcg actgggcgat
    22021 cttcgcggcg accagcaatc cgagttggcc ggcccggact tggccgctga cgtcgacttc
    22081 gtcgggggct ttgagcaggt ggttcatctg cgcccgcgtc tgcggatgca tggggatagc
    22141 ccggtcctcg acttcgaccg ccagcccgtt cgccacgcgc tgcgcacgca ccatcacctt
    22201 cgtcgcggga tcggagcact cgcaggcgtt ctcgatcagc tcggccagca ggtgcgtcag
    22261 gtccgggccc acatggccgg gaagacctag ctcggcgccc acggacccgg cggcgacgga
    22321 cacacgtgga tactgcacga cctcggagac ggcgccgcgc agtgccgtcg cgacgggaat
    22381 gggccggcgc acgctgcgca gggactggcc gcccagcacc gcagtgctct cgacctggcg
    22441 acgcatccgc gtcacgaggt ggtcgatctc gaagatcttg gccagtagct ccgggtcgtc
    22501 ggtcagcatc tccagctcgc tcagtgcctg gagcgccttg ccgaccaggg cgtgctcgcg
    22561 catggccaga cggcgcagca cttccaggag gacgacggac tgggactcgt cgtgcacccg
    22621 tatcagcgac gcgatggcct gcacctggag ggcactcaac gccgtgttga tctcggcgtt
    22681 cggaccggcc gacgttggcg cctgcaggtc cggcagcggc gggcgtcccc cgcggcacag
    22741 ctcatccgcc gaccactgca ccgacttctc gacagccgcc gctgcccccg caaccgctgc
    22801 cagtgccgct gcccagtcct cctccgcggt cgcctgcacg gcccctgccg ccgtacgcgc
    22861 tccgcgagcc gccgccgtgg cgactccggc cagtccgcag accaggcagg ccaggagcca
    22921 cccggggcct acggcggaca ccgaccagag ggggaaggcg gcacccagca gcgcggctag
    22981 cagcaccagg ggcaatgcca cggcgcggcg gacacggtgc agcgtgaacg cgtcgatcgg
    23041 aggtcgccgt ctgcggtggc cggtagcggc cggccgtgcc gggaaggcgc tgtcaggcat
    23101 gggaatcctc gtcaggtggg ggtggctaag cgtgttgcgg cgtcaggtct gcgcaggtct
    23161 ggcgagtgct gcgtggagcc gagcggggcg tcggaaccgc gaccgcgctg cggtggtggg
    23221 aggaatgcgt cgacaggagc tgaaggagcc gggcgctctg gatcaggccc atgtggctga
    23281 atgcctgcgg gaagttgccg agctggcgct gttggacggg gtcgtactcc tcggcaagga
    23341 gcccgaggtc gttgcgcagc gcgaggaggc gttcgaacag ggcgtgggcc tcgtcgaggc
    23401 ggccgatcag ggccagggca tcgacgagcc agaaggagca gaggacgaag gtgccctcat
    23461 cgcccttcag gccgtccacc ccggtacggt caccgatggt cgggtaacgg cgcacgagcc
    23521 cgtccggcga ggagagttca cgacgcactg cgtccacggt gccgatgacg cgggggtcgt
    23581 cgggcggcag gaagccgacg cgggggatca gcagcgtggc ggcgtccagc tctcgggaac
    23641 cgtaggactg ggtgaaggtg ttgcgcaccg gatcgaagcc cttggtgcag acctcgtggt
    23701 ggatggttgc ccgcagctcg atcagcgggg ctacgtcgat gtggagggca ccggcctcgg
    23761 tcaggcggat ggtgcggtcg accgccaccc aggccatcac cttggagtgg acgaagtgcc
    23821 ggcgtgctcc gcggatctcc cagatgccct cgtcgggctc ctgccagcgc tgtgccaggt
    23881 tctcgatgag tcgctggtgc agcacggcgg tggcggcgca gtgggcgaca ccgctctcgt
    23941 gcgcgaggta cagagtctcg atgacctcgc catacacgtc gagctgcagt tggtccgccg
    24001 ccccattgcc gacccgtacc ggggtcgagc cctcgtagcc gggcagccag gacagctccc
    24061 gttcccgcag gtcacgctct ccggtgatcc cgtacatgat ctgcaggttt tccggatcac
    24121 cggccacggc gcgcaagagc catcgccgcc atgcctgcgc ctcctgccgg tacccggtcc
    24181 ccaggagcgc ggccagcgtc gtggaggcgt cccgcaacca agtgaagcga tagtcccagt
    24241 tgcggtttcc gccgatctcc tctggcagcg acgtggtcgg cgccgcgacg attccaccgc
    24301 tcggctcgta cgtcatcgcc ttcagcgcga tcaaggatcg aaccacggcc ccgcgatatg
    24361 gcccctcgta ggtgcagtcc cgtgtccagt cctgccagaa cgtgagcgtc tcggtcagcg
    24421 cggcctcggg gtcgggaacg tcgggcgccg ctgcgtggga cgggcaccag ctgaggacga
    24481 acgccacgct ctgccccgcg gcgacggaga agacactgac catgacgccg tccttctcca
    24541 cctgcgggac gcaggtgtcg agccacagag cgtccgcgcc agcctccgcg atcatgcgcc
    24601 caccgacttc gtgaatccac gggctgacgc tgccgtaccc cggccgtgga cgcatggccg
    24661 agatcatgga gacctcaccg gtcaggccct cgacgatccg gatcacctgc ggtgccccgt
    24721 cgcgcggtgg catgaagtcc aggacatgga ccgaaccggc ctcggtgcgc cataccgatt
    24781 cgaggacgag cgagtcaccg cggtaccggc gctcggcgac tgcttcggag ctggaacggt
    24841 cggcaggagc ggccggagcg atccgccagg tgccgtgttt ctgcgtgccg agcaagccgg
    24901 tgaagacggc cggcgagtcg aaccggggca ggcacagcca gtcgatcgaa ccgtcatcgc
    24961 agacgtgggc actggtctgc atgtcgccga tcaatccgta ctgctcgatg cgcggaagcc
    25021 gtttcatcgt gtggatctcc gtgagccccg caggtccggg gcggtatcgg ggccgccgca
    25081 gcggccggga acggtgggac gagcagaggc cggtggttac cggagcgagg aaggggcgtt
    25141 ccggggcggc ggcaagtcct cgtcggcccc tgcagggccg gccgcgc
//
