LOCUS       NZ_SHKU01000001        21053 bp    DNA     linear   CON 27-MAY-2024
DEFINITION  Streptomyces sp. BK022 Ga0307664_101, whole genome shotgun sequence.
ACCESSION   NZ_SHKU01000001
VERSION     NZ_SHKU01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. BK022
  ORGANISM  Streptomyces sp. BK022
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1305487)
  AUTHORS   Kalluri,U.
  TITLE     Understanding the reciprocal impacts of modified plant cell wall and
            associated microbiome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1305487)
  AUTHORS   Kalluri,U., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 215.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004217355.1-RS_2024_05_27
            Annotation Date                   :: 05/27/2024 02:58:00
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,482
            CDSs (total)                      :: 6,401
            Genes (coding)                    :: 6,280
            CDSs (with protein)               :: 6,280
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 2, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 1 (5S, 16S)
            partial rRNAs                     :: 3, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 121
            CDSs (without protein)            :: 121
            Pseudo Genes (ambiguous residues) :: 0 of 121
            Pseudo Genes (frameshifted)       :: 49 of 121
            Pseudo Genes (incomplete)         :: 92 of 121
            Pseudo Genes (internal stop)      :: 16 of 121
            Pseudo Genes (multiple problems)  :: 29 of 121
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:05:10
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 219942
            Orig. end                         :: 240995
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SHKU01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..21053
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21053
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21053
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11053](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11053
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(466..480)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.81"
                     /tool="antismash"
     misc_feature    complement(593..608)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 24.18"
                     /tool="antismash"
     gene            641..1237
                     /locus_tag="EV284_RS33630"
                     /old_locus_tag="EV284_0217"
     CDS             641..1237
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS33630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV284_0217"
                     /product="hypothetical protein"
                     /protein_id="WP_165425412.1"
                     /transl_table=11
                     /translation="MPDRPSELPQHLVAASRGRRLYLHAMHSVVDWLAFAVWDDGKLVR
                     SLSLSPDSGVIEDIGERLPFELPYWEGRHPVEPFPPFEDEEPYPLPFHPLELGERALLE
                     FFGFYVEGFSDEEDAPEPVVDIWSVELHGLPRDDDVAGRGRGLSKALLEAQPSGAPTAV
                     SHRQPVLERLQSALHRPGDLREVGRGEVADVALDQ"
     gene            complement(1263..1622)
                     /locus_tag="EV284_RS33635"
                     /old_locus_tag="EV284_0218"
     CDS             complement(1263..1622)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003954588.1"
                     /locus_tag="EV284_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0218"
                     /product="hypothetical protein"
                     /protein_id="WP_347402162.1"
                     /transl_table=11
                     /translation="MEEGDLAAGKTIAAEREAWLVFEDEAGQSLTPPRARTWGRRGCTP
                     VVKVRGRGSWRKDQPKGFGWRDLRDLIIRARIQLGGPSVLIWDNVRLHLTKPLRELIEA
                     NSEWLTVFQLPAYAP"
     gene            complement(1532..>1779)
                     /locus_tag="EV284_RS01065"
                     /pseudo=""
     CDS             complement(1532..>1779)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136905.1"
                     /locus_tag="EV284_RS01065"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="winged helix-turn-helix domain-containing
                     protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="QRWTLARIKTLIGRLFRVSYTVEGTWRLLKRHGWSWQQPAGGRSS
                     AMMRLWRCGRRRPGRG"
     gene            complement(1877..2785)
                     /locus_tag="EV284_RS01070"
                     /old_locus_tag="EV284_0219"
     CDS             complement(1877..2785)
                     /EC_number="3.8.1.5"
                     /GO_function="GO:0018786 - haloalkane dehalogenase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (34-148). E-value:
                     8.3e-26. Score: 83.0. Matches aSDomain:
                     nrpspksdomains_EV284_RS01070_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019054896.1"
                     /locus_tag="EV284_RS01070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0219"
                     /product="haloalkane dehalogenase"
                     /protein_id="WP_278045809.1"
                     /sec_met_domain="PF00561 (E-value: 4.8e-21, bitscore: 71.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4.2e-14, bitscore:
                     49.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHRYRKRSDTAMPTLPVLDSTLQYRESGDPDGLPFVFLHGNPTS
                     SHLWRNVLPGVAAPGRRLLAPDLIGMGDSGKPDLAYAFDDHARYLDAWFDALGLTDAVL
                     VGHDWGGALAFDRAARLPGTVRGLAFTETIIKPLVGDEFPEAGRKLFALLRTPGVGEEM
                     ILEKSLFIEGLPDTLATPLDPADMEVYRHPFPTPHSRRPVLAWTRMMPLDAEPADVVAR
                     IERYDAWLAASPEVPKLLAAFEPGPGSMTDQRTVAWCEENIACLEVSRHGLAGHHSSED
                     RPEELASAINDWADRHGVARP"
     aSDomain        complement(2342..2683)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV284_RS01070_Abhydrolase_1.1"
                     /evalue="8.30E-26"
                     /label="EV284_RS01070_Abhydrolase_1.1"
                     /locus_tag="EV284_RS01070"
                     /protein_end="148"
                     /protein_start="34"
                     /score="83.0"
                     /tool="antismash"
                     /translation="PFVFLHGNPTSSHLWRNVLPGVAAPGRRLLAPDLIGMGDSGKPDL
                     AYAFDDHARYLDAWFDALGLTDAVLVGHDWGGALAFDRAARLPGTVRGLAFTETIIKPL
                     VGDEFPEAGR"
     gene            complement(2782..3186)
                     /locus_tag="EV284_RS01075"
                     /old_locus_tag="EV284_0220"
     CDS             complement(2782..3186)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018554266.1"
                     /locus_tag="EV284_RS01075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0220"
                     /product="pyridoxamine 5'-phosphate oxidase family protein"
                     /protein_id="WP_130329331.1"
                     /transl_table=11
                     /translation="MSRPTFQLSPGARAFLTLPHTATLTTLRPDGTPHVTPVRFTFDAA
                     AGLVRVTTRAGARKTRNVEAAGPAARAALCQADGFRWITLEGRPAVTHAPAHLAEAVRR
                     YTVRYRAEPPAPRDLVVVEIAVDRVLDLNL"
     gene            complement(3183..3875)
                     /locus_tag="EV284_RS01080"
                     /old_locus_tag="EV284_0221"
     CDS             complement(3183..3875)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="other (smcogs) SMCOG1199: NmrA family
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018524784.1"
                     /locus_tag="EV284_RS01080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0221"
                     /product="NAD(P)H-binding protein"
                     /protein_id="WP_130329333.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.1e-05, bitscore:
                     20.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRIAVFGANGPTGRRLIEQALAAGHEVVAVTRRPGSLSARAGLSV
                     AVADATDPAAVDAAIDGTDAVLSALGARFSKGTVTTYSASATVITGAMARHGIKRLLAV
                     SSSIADPNWRPTGAHFFNHVLDPLVNRRLGRTLHEDMRRMEAVIRRTGLDWTLVRPSGL
                     FEHPVVTDYHTAETSADGVFTARADLAASMLREMTERRYVRTAMGVVTTAVKPNIAKLI
                     WNEGVKKK"
     gene            3952..4686
                     /locus_tag="EV284_RS01085"
                     /old_locus_tag="EV284_0222"
     CDS             3952..4686
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014044510.1"
                     /locus_tag="EV284_RS01085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0222"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_130329335.1"
                     /transl_table=11
                     /translation="MNNAVPAPARTRGRPRGNPPTRESIVSAARSLFLEHGYRSTTLRA
                     VAGAVGVDPALIVYHFGSKKGLFADVMQFQCANALARDEVLGGDPATLPDRLIDAVTDL
                     WEDADFQQLTIQGDEATEVIREYLERELLARLVEFLGGRDATARATAVVTILGGLIYTR
                     YLNPLPTPAALTPSEIRHSLTPALRAVLAPRLRAAAPATAGRRGRPTPGGGAVHRGGFT
                     GRNSYVTAEKQQANKEAGAENH"
     misc_feature    complement(4746..4760)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    5008..5022
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.8"
                     /tool="antismash"
     misc_feature    5324..5344
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.46"
                     /tool="antismash"
     gene            5404..5853
                     /locus_tag="EV284_RS01095"
                     /old_locus_tag="EV284_0224"
     CDS             5404..5853
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS01095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV284_0224"
                     /product="hypothetical protein"
                     /protein_id="WP_130329336.1"
                     /transl_table=11
                     /translation="MEWWKTIAPLVGVVLGILGTLVGQKLSDSRTLRRDRLLAQEEAKI
                     RLAAERATLQREAIMEIQHALEGSMAANQLPPGARMSEQFRTAATESALHLRAHIARLE
                     DRELAASVLEWLEPHRNAAAARAALDALQDRLSRHLRGLYADGPA"
     gene            5914..7128
                     /locus_tag="EV284_RS01100"
                     /old_locus_tag="EV284_0225"
     CDS             5914..7128
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014047574.1"
                     /locus_tag="EV284_RS01100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0225"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_130329338.1"
                     /transl_table=11
                     /translation="MANEDLGKTLRRLRRLASLTQEELAERSGVSVDVIRQLEQGRKHS
                     ARLPTLHALANGLGVELTTLLGDPPAVSTSGENDGPRFVAVRRAIMPALWGPAPEPPGP
                     DFSMNSLREAIADGWTHYHSADFDTVMKALPDLISDARSATASGSDAARKTGFAALGKA
                     LQLAGHVAVRMGKTDLALISLERAIDAAGQSSDPLLLPMIVNSTAWTYQRQGRLEDALG
                     IALRAADDMANAGHTDTADGLKVWGALTMSAATSAARSGDYERAAAMMETAEKEAARVA
                     KLPDGGDNRMVSVFSPSSVRIERVRLAVQYGHPQDALAMAKGMRLSKDTPPSWRTWLLL
                     DVARAHTDTGDAAGAVKTLESLRRVAPTWMQHHTLAVAIVRDLWALPNHPPGLRSLAEF
                     LGICE"
     misc_feature    7169..7182
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     17.22"
                     /tool="antismash"
     gene            7254..7670
                     /locus_tag="EV284_RS01105"
                     /old_locus_tag="EV284_0226"
     CDS             7254..7670
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018522001.1"
                     /locus_tag="EV284_RS01105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0226"
                     /product="ATP-binding protein"
                     /protein_id="WP_130329340.1"
                     /transl_table=11
                     /translation="MPQPTTRARHTGHPGYSETLPRQPESAATARRLLRAACAVWGLEA
                     LVEDGVLIVSELVANAVQHARRESIRVVIDRPDAAWVRVGVADLSRARPVRQEADDNNE
                     GGRGLRLVAALAADWGTDERRWGKIVWADLKGRG"
     gene            7673..7828
                     /locus_tag="EV284_RS32540"
                     /old_locus_tag="EV284_0227"
     CDS             7673..7828
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS32540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EV284_0227"
                     /product="hypothetical protein"
                     /protein_id="WP_165425422.1"
                     /transl_table=11
                     /translation="MGEAPGRSVARAHLSQLIELFGTDGCLRISTAPAEPGPPAVGGEA
                     EDHEQN"
     misc_feature    8147..8160
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            8328..8531
                     /locus_tag="EV284_RS01110"
     CDS             8328..8531
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EV284_RS01110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_130329342.1"
                     /transl_table=11
                     /translation="MRNAKIESAPFALYPWITRAGSLGAAHRYPEVSGAPPADPFTVAA
                     AFSGAAVRNRPPLPFAATCSPL"
     gene            8542..9984
                     /locus_tag="EV284_RS01115"
                     /old_locus_tag="EV284_0228"
     CDS             8542..9984
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003963.1"
                     /locus_tag="EV284_RS01115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0228"
                     /product="family 2B encapsulin nanocompartment shell
                     protein"
                     /protein_id="WP_130329344.1"
                     /transl_table=11
                     /translation="MSTPDIATASAVDGPEPGPPADRPATSLGTRAARQLATTTKSRPQ
                     MQGISSRWLLRSLPWVDVRGGTYRVNRRLQLRTGRGRVHFEQNGADDIRVVPQTLTELP
                     VLRGYPDLDVLRELASRFRPQEVRPGQVLFEAGQPVTEAYLVVHGRFTRYTAGRYGEEE
                     ILGVVTDGGQLGDEAVGQSEPLWPASVRAETAGVVLVLPWAAVRELTDRVPSLDTHLRE
                     YAERQARPMNRKGEAEVPLQAGHVGEETLRGGFVDYELAPREYELSLTQTVLRVHTRVA
                     DLYNEPMDQTAEQLRLTVEEIRERQEWELVNNREFGLLHNIDYGQRISTHSGAPTPDDL
                     DELLTMRRSTKVFLAHPKAIAAFFRQCNRRGLVPGTANIDGREVPAWRGVPLLPCGKIP
                     VTEDHTSSIIALRTGEASQGVIGLYQTGIPEEYQPGLNVRFMGIDRAAIVNYLVTAYYS
                     LAILVPDAAGVLENVQIGRTAE"
     gene            10001..11053
                     /locus_tag="EV284_RS01120"
                     /old_locus_tag="EV284_0229"
     CDS             10001..11053
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126202.1"
                     /locus_tag="EV284_RS01120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0229"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_130329346.1"
                     /sec_met_domain="T1TS (E-value: 3.9e-54, bitscore: 180.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTSTDSYALPGPPDIARSLRRERRTGVIPGLHHRPAAPADPAKA
                     AEIDRRLETWARGLDLFPEAWQGDFSGFQFGRAVALQHPGALDLERLTVAGKLLLAENV
                     VDSCYCEEDEGRGGARRGLGARLIMAQSAIDPYHGVPELEEEWRAGMRADGPLRSYHFA
                     LADYAGFATPSQTGRFVHDIARLHMGYLAEAAWAETRYVPRVWEYLVMRQFNNFRPCLS
                     IVDAVDGYELPEQVYARPEIQRVTALACNATTIVNDLYSFTKELASDPDHLNLPQVVAA
                     NDRRGLKAAYLRSVEIHNRIMAAFEEESALLSAGSPLVERYLQGLAAWVSGNHEWHATN
                     THRYHLPDYW"
     gene            11121..11999
                     /locus_tag="EV284_RS01125"
                     /old_locus_tag="EV284_0230"
     CDS             11121..11999
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (92-252). E-value: 8.8e-13. Score:
                     39.0. Matches aSDomain: nrpspksdomains_EV284_RS01125_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007501742.1"
                     /locus_tag="EV284_RS01125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0230"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_242625487.1"
                     /transl_table=11
                     /translation="MTTVPAPTAPAVAVPTQSTYQHRVAEYWNAEENPVNLELGKVDDL
                     YHHHYGIGAADRSVLDEPDPGRRRERITAELHRLEHAQAELLAAHLGPLSPADRVFDAG
                     CGRGGGSVTAHLRYGCHADGVTISAKQCDFANEQARARGIDDTVRYHHRNMLDTGFETG
                     AYAASWNNESTMYVELDLLFAEHARLLRRGGRYVTITGCYNNAYGQASREVSLINAHYI
                     CDIHPRSEYFKAMARNRLVPVHVEDLTAATVPYWELRKEADHLVTGIEDAFLDAYRNGS
                     FQYLLIVADRV"
     aSDomain        11397..11876
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV284_RS01125_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="8.80E-13"
                     /label="EV284_RS01125_oMT.1"
                     /locus_tag="EV284_RS01125"
                     /protein_end="252"
                     /protein_start="92"
                     /score="39.0"
                     /tool="antismash"
                     /translation="PLSPADRVFDAGCGRGGGSVTAHLRYGCHADGVTISAKQCDFANE
                     QARARGIDDTVRYHHRNMLDTGFETGAYAASWNNESTMYVELDLLFAEHARLLRRGGRY
                     VTITGCYNNAYGQASREVSLINAHYICDIHPRSEYFKAMARNRLVPVHVEDLTAAT"
     gene            12167..12823
                     /locus_tag="EV284_RS01130"
                     /old_locus_tag="EV284_0231"
     CDS             12167..12823
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019325875.1"
                     /locus_tag="EV284_RS01130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0231"
                     /product="HEAT repeat domain-containing protein"
                     /protein_id="WP_130329350.1"
                     /transl_table=11
                     /translation="MTAQHTRLGKAMGAEDTSVRLQAAMAVGSRADPVFLDALVERCAV
                     EPDFFVRDMLSWALTRLPPDVTLPRLREELGSWCGQARSQALHTLSKIDDKSTWGWITR
                     DLLRDDDEVARTAWRAAVVLVPEGEERGLADELVRQLGRGDRDVRLSLSRALVDLGEES
                     RPALERAARHPEPGVAAHARATELLRRDPEAGFDAAVEEARRTVVLGPKHGAAQA"
     gene            12835..13866
                     /locus_tag="EV284_RS01135"
                     /old_locus_tag="EV284_0232"
     CDS             12835..13866
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003711.1"
                     /locus_tag="EV284_RS01135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0232"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_130329352.1"
                     /transl_table=11
                     /translation="MLIGEVARRSGVSARMLRHYDDLGLVRPTGRTVGGYRAYSADDVR
                     RIFHVESLRSLGLSLKQIRRALEDPAFTPSALVGDLIRWAEDRLARERELLERLRVIDA
                     SAPAGWQDVFRVVELMRELDSSSAARRQQAVLTRPEGVPVPAELLAGAVLTESDPHVAG
                     ALRWALARTGDDGVTALAAAARSGDVEVRRRAVLAIAGMAEVPEAIPVLTDRLEDPDAH
                     VRGQAALALGTQGVAAAVPALVRMVVDGTNDVDAAEALGILSRDPASATRITTLLADRL
                     ADPTAGPATRIRLIQALVELEGTAPLEILRRLARDEDRTVALVASALAGVVEERAREVL
                     DDP"
     gene            complement(13888..14808)
                     /locus_tag="EV284_RS01140"
                     /old_locus_tag="EV284_0233"
     CDS             complement(13888..14808)
                     /EC_number="3.6.1.26"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0008715 - CDP-diacylglycerol diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014650.4"
                     /locus_tag="EV284_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0233"
                     /product="CDP-diacylglycerol diphosphatase"
                     /protein_id="WP_242625488.1"
                     /transl_table=11
                     /translation="MNDQQNAKEVPRRQFVALSGALGAATVLTGAVAMGGGTAAAASGA
                     DAGPGPDSCPTTPPPGGTGSCPPASLQSVCGRPTDNDPLWHDVQYCTSGIVPPPPQTKP
                     DCLKMTANYVVLHGKPETTHNYLLLPTCRVTGIECPFLVTSGPPNYWHEAWENARSGGD
                     VPVQYPNIGLGINSQNARRFDQLHIHMAGVRASTQRRLQELESQGRMATSPAQWANPAN
                     QAAVTGSAGDRVYRVLRLPNLRDNLFNLLYTNVVRPGSLNMADQTIIVVPKITATGFAG
                     AFYVLNSDTSIHDGTSTCDYLLVYS"
     gene            complement(14999..16471)
                     /locus_tag="EV284_RS01145"
                     /old_locus_tag="EV284_0234"
     CDS             complement(14999..16471)
                     /NRPS_PKS="Domain: AMP-binding (17-393). E-value: 2.7e-67.
                     Score: 219.0. Matches aSDomain:
                     nrpspksdomains_EV284_RS01145_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140466.1"
                     /locus_tag="EV284_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0234"
                     /product="AMP-binding protein"
                     /protein_id="WP_130329354.1"
                     /sec_met_domain="AMP-binding (E-value: 6.2e-67, bitscore:
                     222.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTPQPGFPLGDIPAAYAAERRDSAAVRAGDAELTWEELYRASDA
                     VARGLRLSGVTPGHIVPLMLPNGLDVVVAAFACLRIGAVPQPLSTRLAPAEERAILALS
                     EPPVVIGLQEGASGRSTTVAELRRLGAGEGEPATELTTVIGPSWKAPTSGGSTGRPKII
                     LSGAEGAFNPFDMEAWGLRPGERSLVTAPVHHNAPFSTAMTTLFNGGTVTLLERFDAER
                     VLSEVERHAITWVYLVPTMMRRILALPEPVRARYDLSSLVSVWHCAEPCPPATKQAWID
                     WLGADRIWELYAGTEAQAGCTISGTEWLAHRGSVGRPAWGEIKIVGLDGTPVTEPGVAG
                     EIFMRVADGKPPAFRYLGAEVQETHGWSTLGDIGEFDADGYLYLHDRRSDMLLVGGVNV
                     YPAEIEGALTEHPHVLSSAVIGLPDPDRGNRVHAIVQIEEGRTTTPEEINDFLATRLSP
                     HKRPRSVELVTEPLRSAAGKLRRSALRAERLE"
     aSDomain        complement(15293..16420)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV284_RS01145_AMP-binding.1"
                     /evalue="2.70E-67"
                     /label="EV284_RS01145_AMP-binding.1"
                     /locus_tag="EV284_RS01145"
                     /protein_end="393"
                     /protein_start="17"
                     /score="219.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AAERRDSAAVRAGDAELTWEELYRASDAVARGLRLSGVTPGHIVP
                     LMLPNGLDVVVAAFACLRIGAVPQPLSTRLAPAEERAILALSEPPVVIGLQEGASGRST
                     TVAELRRLGAGEGEPATELTTVIGPSWKAPTSGGSTGRPKIILSGAEGAFNPFDMEAWG
                     LRPGERSLVTAPVHHNAPFSTAMTTLFNGGTVTLLERFDAERVLSEVERHAITWVYLVP
                     TMMRRILALPEPVRARYDLSSLVSVWHCAEPCPPATKQAWIDWLGADRIWELYAGTEAQ
                     AGCTISGTEWLAHRGSVGRPAWGEIKIVGLDGTPVTEPGVAGEIFMRVADGKPPAFRYL
                     GAEVQETHGWSTLGDIGEFDADGYLYLHDRRSDMLL"
     gene            complement(16507..17892)
                     /locus_tag="EV284_RS01150"
                     /old_locus_tag="EV284_0235"
     CDS             complement(16507..17892)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1074: major
                     facilitator family transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018549508.1"
                     /locus_tag="EV284_RS01150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0235"
                     /product="MFS transporter"
                     /protein_id="WP_130329356.1"
                     /transl_table=11
                     /translation="MASSAQAHVQGNGSDPVTAPVRRANWRLLAAGLTGSSIEWYDFFL
                     YGTAAALVFPHVFFPHSSAFMGTLLSFSTFWAGFVARPLGGLLAGHFGDKHGRKPTVVA
                     CLIGMATATFLIGCLPSAASVGALAPVLLVLLRFVQGAAAGGQWGGIALLLTESAHPKR
                     RGFAGTFGQTSVPVAVIIVNLVFTTTGSLVSGDAFLDWGWRIPFLLSAVMFPVVLHIQN
                     KVEDTPDFRELKEAAARRPEASVVRAPLTEAVRRNWRTILLGCGTLSATNSLFYVSITG
                     LLSYGTTTLHMDRDSLLTVTLFSSALMAGILPCAGHLSDRFGRRRLILVGGLGVAAWAF
                     PYFALVNTASAPLVFVAITVGFLFQGLTYGPMAAFLGELFAPHVRYSSASLAYQLSAIV
                     VSGGTPILMTTVIAKTGSTTLVAVYIALMGLITFAAAWFLPETNPAEVRRDPEALPGSQ
                     LYS"
     gene            18084..19892
                     /locus_tag="EV284_RS01155"
                     /old_locus_tag="EV284_0236"
     CDS             18084..19892
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006140468.1"
                     /locus_tag="EV284_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0236"
                     /product="GAF domain-containing protein"
                     /protein_id="WP_130329358.1"
                     /transl_table=11
                     /translation="MAHSDSEPAGAGGQGELAAYRLRRERELSSLYATVRSLTVLGEVD
                     QVLLSIVREAHELIGSDFVYLSLRDTAGALVLSASAGTISSEFSSARMPAGAGLGGWVI
                     ETRAPVWVSDYRHADGFHRDPVFDRLVSDEGLVALLGVPLLVGERVIGVLFAADRTERP
                     YEKDEVALLSAFADHAATALNNARLYDESRVALQRLQDAYRVIEGQVATMERAAAVHEA
                     LTHVVLTGGGPGDIAQSLVDHLEGVITIRDRDDEVVATRSPGVVTAGEDPGLEAELLAR
                     ARRTGRCVHGEGSDGTVLSVAAIQAGGSHLGSLSLRRRAATESADVRMLERSAQITGLL
                     ALLRDARVEAEERVRGELLMELLSHPPLQPVHPALRDRALARGVDVDRLDTLVAADCHD
                     RSTADVVRELHALSAEFSGLAGEFLGRATMLLRAEDAETAVRTLHQRLRRRLGTPVLVV
                     ADRITGHDRAHSYTLAVRCLDVMRSLGETDRGATTRRYAMYGLVFDPRRAQELEGFVTD
                     SLGPLLDYDRRRATDLVSTVAAYFAHSGNLSRTAHALHVHTNTLLKRLDRIAALLGDDW
                     RSADSALRLHLAVRLHQLRAVLDGPG"
     gene            complement(19894..20709)
                     /locus_tag="EV284_RS01160"
                     /old_locus_tag="EV284_0237"
     CDS             complement(19894..20709)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014138248.1"
                     /locus_tag="EV284_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV284_0237"
                     /product="hypothetical protein"
                     /protein_id="WP_130329360.1"
                     /transl_table=11
                     /translation="MSEDQATPVEYSAAVDRYLAKAGLGPASRRVYRISLLGWAWPLVG
                     RRTPTGRARRGAHPPSVPLSVLDDPGTQERLRRALADRSTTARPTTLVRELACFRAAIA
                     WWLAQSWITTDPARDLAQPLPAASPRPPDRARAALALRAPLRELAFWYFLHESGAPVEH
                     VLALDIDHLDLPARRTRPGASARLAWGEGTARLLPLLLAGRTAGPVFVTARRAPATTPP
                     ADRCPVTGRGRLSYRRAAELFTAATRPLDPSGHGWTLLALRDRDGTATP"
     misc_feature    complement(21001..21015)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.56"
                     /tool="antismash"
ORIGIN
        1 cacctgatgt gccggagtga agaatggact ccgtgatgct tgatcaatgc ggcctgggga
       61 tcaatgggac gtggaaaaca agaccgaaac gcgcggggtt cgaaggcctc ctcgccgctc
      121 tttacctggt cgcccactcg caatgatcgc ggcgtccatt cagcttggcg tgatagcacc
      181 ctcacggcgc agggggcttc attgaacgct ttctatacga cgagtgaatg acgagtagcg
      241 cccttatggc atgagtggac cgggcggcgg tggaccgatt ccgcggctac tgagcttgaa
      301 ctcgtgatgt cggccggggc atcgggtgga ttgctcgtcg tctgttggag gtgatcggta
      361 acctcccgac aggacttcac acagaccgag gacggggagc atgggagcga agaccgcagt
      421 gctggcctat gcagacgatg cgattgccaa cctgctccaa gacgtatcaa cgagtgagat
      481 cgacggggct atggcactgg ttgctcgggt tcgccccggt caccgcgtag acgcggacga
      541 cgaagaggct taggaactgg cggacgcgct ctacccgccc gaggggaccg tctgtgcgct
      601 gtcggcgtcg ggccttgacc tggtctgcga ccaggaggtc atgcccgacc ggccctcgga
      661 acttccgcag cacctggtcg cggccagccg gggccgacgc ctctatctcc acgctatgca
      721 cagcgtcgtc gactggctgg ccttcgcagt ctgggacgac ggcaaactcg tacgctcact
      781 gagcctgtcc ccggacagtg gcgtcatcga ggacatcggc gaacggctcc cgttcgagct
      841 gccgtactgg gagggccggc acccggtgga gccctttccg cccttcgagg acgaggagcc
      901 atacccgctg ccgttccatc cgctggagct gggcgagcga gcgctgctgg agttcttcgg
      961 cttctacgtc gaaggcttct cggacgagga ggacgccccc gagccggtgg tggacatctg
     1021 gagcgttgag ctgcatggcc ttccgcgtga cgacgacgtc gcaggacgag gccgcggact
     1081 gagcaaggca ctcctggaag ctcaacccag tggcgccccg acggccgtca gccaccgtca
     1141 gccggtactg gagcgtcttc agtcggcgct tcaccgcccg ggtgatctcc gcgaggttgg
     1201 ccgcggcgag gttgccgatg tcgcgcttga ccagtgacca gatcccttcg gtgggattga
     1261 gatcatgggg cataggcagg caactggaac accgtgagcc actcggagtt cgcttcgatg
     1321 agctcgcgta ggggtttcgt caggtgcagc cggacgttgt cccagatcag cacacttggc
     1381 ccaccgagct ggatgcgggc ccggatgatc aagtcccgga ggtcgcgcca gccgaagccc
     1441 ttcggctggt ctttgcgcca ggacccccgg ccgcgcacct tcacgaccgg cgtgcagccc
     1501 cgacgccccc aggtcctcgc tcgcggcgga gtcagcgact gcccggcctc gtcttcgaag
     1561 accagccaag cctcgcgctc agccgcgatg gtcttacccg cggccaggtc tccttcttcc
     1621 acacctccac agccgcatca tcgcgctcga ccgcccgccc gcaggctgct gccagctcca
     1681 accgtgccgc ttcagcagcc gccaggtgcc ctcgaccgtg taggagacac ggaacagccg
     1741 gccgatcaga gtcttgatcc gtgccagcgt ccaccgctgg tgcacaccga aggggttgtg
     1801 gcgcacgtag cgggttgccg gggtcgggca ggcggtcgcg ggcggcacgg atccgcaccg
     1861 ccgtgatcga ggacgcctac gggcgtgcca ccccgtgacg gtcggcccag tcgttgatcg
     1921 ccgaggccag ctcctcgggg cggtcctccg aggagtggtg gccggccagg ccgtggcggg
     1981 agacctccag gcacgcgatg ttctcctcgc accaggccac ggtccgctgg tcggtcatcg
     2041 agcccggtcc cggctcgaac gcggcgagca gtttggggac ctcggggctg gcggccagcc
     2101 aggcgtcgta ccgctcgatg cgggccacga cgtcggcggg ctcggcgtcc agcggcatca
     2161 tgcgcgtcca cgccagtacc gggcggcggc tgtgcggggt cgggaagggg tggcggtaga
     2221 cctccatgtc ggcagggtcg agcggggtgg cgagtgtgtc cgggagcccc tcgatgaaca
     2281 gcgacttctc caggatcatc tcctcgccca ccccgggggt gcgcaggaga gcaaacaact
     2341 tccgcccggc ttccgggaat tcgtcaccga ccagcggctt gatgatggtc tccgtgaagg
     2401 cgaggccgcg gacggtgccc gggaggcggg cggcgcggtc gaaggcgagc gcgccgcccc
     2461 agtcatggcc gacgaggacg gcgtcggtga ggccgagggc gtcgaaccac gcgtcgaggt
     2521 aacgggcgtg gtcgtcgaag gcgtaggcga ggtcgggctt gccggagtca cccatgccga
     2581 tgaggtcggg ggccagaagg cggcggccgg gcgcggccac cccaggcagg acgttccgcc
     2641 acaggtggga ggaggtgggg ttgccgtgaa ggaagacgaa gggcagcccg tccgggtcgc
     2701 cggactcgcg gtactggagg gtggaatcga ggacggggag ggtgggcatg gcggtgtcac
     2761 tccgctttcg ataccggtga ttcagaggtt gaggtccagg acgcggtcga cggcgatctc
     2821 gacgacgacc aggtcccgcg gggcgggcgg ctccgcgcgg tagcggacgg tatagcggcg
     2881 gaccgcctcg gccaggtgag ctggggcgtg ggtgacggcg ggccggccct cgagcgtgat
     2941 ccagcggaag ccgtccgcct ggcagagcgc tgcacgggcc gccggcccgg ccgcctccac
     3001 gttccgggtc ttgcgggccc ccgcccgggt ggtcacccgg accaggccgg cggccgcgtc
     3061 gaaggtgaag cggacggggg tgacgtgcgg agtgccgtcg ggacggaggg tggtgagggt
     3121 ggccgtgtgc gggagagtga ggaacgctcg tgcgccgggc gaaagttgga acgtggggcg
     3181 gctcacttct tcttcacgcc ctcgttccag atcagcttgg cgatgttcgg cttcacggcc
     3241 gtggtgacga cgcccatggc cgtacggacg taccgccgct ccgtcatttc gcgcagcatg
     3301 ctcgcggcga ggtcggcacg ggcggtgaag acgccgtcgg cgctggtctc ggcggtgtgg
     3361 tagtccgtga cgacggggtg ctcgaacagg cccgaaggcc ggaccaaggt ccagtcgagg
     3421 cccgtccgac ggatcacggc ctccatacga cgcatgtcct cgtggagggt acggccgaga
     3481 cgtcggttca ccagtgggtc gagcacatgg ttgaagaaat gcgcgccggt agggcgccag
     3541 ttcgggtcgg cgatgctgga gctgacggcg agcagccgct tgatgccgtg gcgggccatg
     3601 gccccggtga tgacggtggc gctcgcggag tacgtggtga cggtcccctt gctgaagcgc
     3661 gcgcccagcg cggagaggac ggcgtccgtg ccgtcgatcg cggcgtcgac agccgccggg
     3721 tcggtggcgt cggcgacggc cacggaaagg ccggcccgcg cggacaggga gccgggtctg
     3781 cgggtcacgg cgacgacctc gtggccggcg gccagggcct gttcgatgag gcggcggccg
     3841 gtcggtccgt tggcgccgaa gactgcgata cgcacggtgt cgggtcatcc cttcgtgtgg
     3901 tggcgggaac gcccttgact gtgctgctca ctccacgcag gctcaacgct gatgaataac
     3961 gccgtccctg cccccgcccg cacccggggc cgcccccgcg gcaacccgcc gacccgtgag
     4021 tcgatcgtct cggcggcccg ttcgctgttc ctggagcacg gctaccggag caccaccctg
     4081 cgtgcggtgg cgggggccgt cggagtcgac ccggcgctga tcgtgtacca cttcggctcg
     4141 aaaaagggcc tgttcgcgga cgtgatgcag ttccagtgcg ccaatgcgct ggcgagggac
     4201 gaggtcctcg gcggcgatcc ggccaccctc cccgaccgcc tgatcgacgc ggtgaccgac
     4261 ctctgggagg acgccgactt ccagcagctc accatccagg gcgacgaagc caccgaggtg
     4321 atccgcgaat acctggaacg cgagctgctg gcccggcttg ttgaatttct cggcggccgg
     4381 gacgccaccg cccgcgccac ggccgtggtg acgatcctcg gcggcctcat ctacacccgc
     4441 tacctcaacc ccctccccac ccccgccgcc ctcaccccgt ccgagatccg tcacagcctg
     4501 accccggcgc tgcgcgcggt actggccccg aggctacgcg ccgcggcgcc cgccactgcc
     4561 ggccgacggg gcaggccgac cccgggcgga ggcgccgtcc accggggcgg cttcacaggc
     4621 cgaaacagct atgtcaccgc cgagaagcaa caggccaaca aggaagcagg ggcagagaac
     4681 cactgagcca ggctctggtc accgccctct cccagagcag atccggcgag ttggcccagc
     4741 ccggcaggca cggatcttcc gctgcggtgg tcagcgaatt cggcactcgg tgatcaccgg
     4801 gagccgtgcc tgcgcggcta tctgccgatc catcaccatg gcgaccgagt tggcatatca
     4861 ggcccatgtc gccgtctggc ggcggaccta tgaccgcgag tggggaccag ttggggatcg
     4921 cacggagagg cccttcgggt cctctcttga tcgtttccag aggcgccgtc tcacgatttc
     4981 tcccaaacgc tattgatcaa ggtcagccga gcagttcggc cagctgctcc gagcccgaga
     5041 ctgcgggtcg cggtgcacgt aggtccgctt cgtgaatccg agatccgagt gaccggcccg
     5101 agcggagacc agcgtgtccg gcactccgtt gttcgccatc cacgacaggc aggcgtgacg
     5161 cgcgtcgtac caccgcacct tccgtacgcc cgtggtggcc gtcagcttgt gcgcctcgca
     5221 ccggaggtga tggccggtcc cctacggggc atggccgccg aggggcggcc ggaacttccg
     5281 gcggcctgaa taccaggaag tcgcagcccg tgtgagctgc ggtttcctgt cgtgtagacg
     5341 gtcagccggc ctgctaccac caatccacag tccaacgtcg cgcgccctgg ttaccatccc
     5401 ccgatggaat ggtggaaaac gatcgcgcca ctggtcggtg ttgtcctggg aattctcggc
     5461 acgctggtcg ggcagaagtt gtccgactca cgcaccctcc ggcgtgaccg gctgctcgca
     5521 caggaagaag cgaagatccg tctggccgca gagcgggcga ctctccagcg ggaagcgatc
     5581 atggagatac agcacgcgct cgaaggcagc atggccgcca accagctgcc gcccggggcc
     5641 aggatgagtg agcagttccg gacagcggct acggaatccg cgctgcatct ccgtgcccac
     5701 atcgcccggc ttgaagaccg cgagcttgcc gccagtgtgc tggagtggct ggagccgcac
     5761 cggaatgcgg cggcagcacg ggcggcgctc gatgcacttc aggaccggct gagccgccat
     5821 ctccgagggc tctacgcgga cggccctgct tagcgcgcga acggtggcat catcagcgcc
     5881 ctgtcccgcg cacggcgggc gtaccgtggc agcgtggcaa acgaagacct ggggaagact
     5941 ctgcgccgcc tgcgccgtct ggcctccctc acacaagaag agctggccga gcgctccggc
     6001 gtatccgttg acgtgatccg tcagctcgaa cagggacgga agcattcggc gcgtctgccc
     6061 acgctgcacg ccctggcgaa tggtctcggt gtggagttga ccacgcttct cggggacccg
     6121 cctgccgtgt ccacttccgg ggagaacgac ggtccccgct tcgtggcggt gcgccgtgcc
     6181 atcatgcccg cgctctgggg accggcgccc gagccgcctg ggcccgactt ctccatgaac
     6241 agcctgcgtg aggcgatcgc ggacggctgg acgcactacc actctgccga tttcgacacg
     6301 gtgatgaagg cgctgccaga cctgatctcg gatgcgcgct ccgccaccgc atccggcagc
     6361 gacgccgcgc gcaagaccgg tttcgccgct ctggggaagg cacttcagct cgccgggcac
     6421 gtagccgttc ggatgggtaa gacggacctc gctctgatca gcctcgaacg cgccatagac
     6481 gctgccggac agtcttccga tccgctgcta ctgccaatga tcgtcaactc cacagcgtgg
     6541 acgtaccagc ggcaaggccg tctggaagac gcgttgggca tcgccctacg ggccgccgac
     6601 gacatggcga acgcgggtca tacggatacg gccgacggcc tgaaggtatg gggtgcgctg
     6661 accatgagcg ccgccacatc cgccgcgcgc agcggcgact acgagcgcgc tgccgcgatg
     6721 atggagacgg ccgagaagga agccgcccgc gtcgcgaagt tgccggacgg cggagacaac
     6781 cgcatggtca gcgtcttcag tccgtcgtcg gtccgcatcg aacgcgtccg gctcgcagtg
     6841 cagtacgggc acccgcaaga cgccctggct atggcaaagg gaatgcggct cagcaaggac
     6901 acgcctccgt cgtggcgtac ctggctgctg ctggacgtgg cccgagcgca cacggacact
     6961 ggggatgcgg ccggagcggt gaagaccctg gagtccctgc gtcgtgtggc gccgacgtgg
     7021 atgcagcacc acaccttggc cgtggcgatc gtgcgcgacc tgtgggcgct ccccaatcac
     7081 cctcccggcc tgcgatcctt ggcggagttc ctggggatct gcgaatagcg tggcgaaagt
     7141 gggacgttgc gcccctgtca gcgttccagg catgtcgctt gcatgagcgg acagcgcccc
     7201 ggcggccgtg tgaccggccc cggggctggc cgatctgaag gaagcagacc gacatgccgc
     7261 aacctacaac ccgggcccgc cacaccggcc accccgggta cagcgagacc ctgccgaggc
     7321 agcccgagag cgcagccacc gcgcggcgcc tgcttcgtgc cgcgtgtgcc gtctgggggc
     7381 tggaggcatt ggtcgaggac ggggtgctga tcgtctccga gttggtggcc aacgccgtgc
     7441 agcacgccag gcgggagtcc atccgggttg tcatcgaccg ccccgacgcc gcgtgggtgc
     7501 gtgtcggcgt cgcggatctc tcccgggcgc ggccggtgcg gcaagaagcc gacgacaaca
     7561 acgagggcgg gcgtggtctg cgtctcgtgg cggcgctggc cgccgactgg ggcaccgacg
     7621 agcggcgctg gggcaagatc gtgtgggcag acctgaaggg gcgcgggtga tcatgggaga
     7681 ggcccccggc cgcagcgtgg cgcgcgccca tctgtcgcag ttgatcgagc tgttcggtac
     7741 ggacggatgc ctgcggatca gtaccgcccc tgctgaaccc gggccgcccg ccgtcggcgg
     7801 agaggccgaa gaccacgagc agaactgacc gccccaaggc gcggcgaagc cccggctcgg
     7861 tgaacttcac cgagccgggg ctgcgtcgtc tcacagaggt ctcacgaact gaaccgacta
     7921 acctggaatt tgtggcgccg acctggacgt ttccgccctt cctggatctc acggaccccc
     7981 ctggactgtg tttcgttcac tgggggtctg ggggtctggg ggtctggggg ggtgcaggtt
     8041 caaatcctgt cgtcccgact ttacgaagtc gctggtgagg gccggttacg gagaaatccg
     8101 caaccggccc ccggccgctg tcggcggacc agttggggac cgagtcttga cccggctcag
     8161 cgggtcgtga cgctcgggcc ggcagggagc agacgcagtg tcgccggcga gcccgcgcgc
     8221 tcgcccttgc cgatggaggt cccccgccag gatgccccct gcgcgctccg aggcggagga
     8281 ccggcgcgtg atcaccagcg ctcccccgag tgcttccatc agcaggtttg cgcaacgcga
     8341 agatcgaatc cgcccccttc gcgctgtatc cgtggatcac gcgcgctggt tcgcttggcg
     8401 cagcacaccg gtatccggag gtgtccggag caccaccggc cgatccgttc accgtcgccg
     8461 cagcgttctc cggcgccgcc gtccgcaacc gtccgccact gccgttcgcc gccacctgct
     8521 cacctctgtg atgggaggac agtgtccaca ccggacatcg ccaccgcttc cgccgtcgac
     8581 gggcccgaac ccggcccccc ggccgacagg ccggccacca gcctgggcac ccgggcggcc
     8641 cgccagctcg ccaccaccac caagtcgcgg ccgcagatgc agggcatctc ctcccggtgg
     8701 ctgctgaggt cgctgccgtg ggtggacgtg cgaggcggta cctaccgggt caaccggcgc
     8761 ctccaactgc gcaccggccg agggcgcgtg cacttcgagc agaacggcgc ggacgacatc
     8821 cgggtcgtcc cgcagacgct gaccgagctg ccggtcctgc gcggttaccc ggacctcgac
     8881 gtactgcggg agctggcctc ccgattccgg ccgcaggagg tccggcccgg gcaggtgctg
     8941 ttcgaggccg ggcagccggt caccgaggcg tacctggtgg tgcacggccg cttcacgcgg
     9001 tacacggcgg gcaggtacgg ggaggaggag atcctcgggg tcgtcaccga cggcgggcag
     9061 ctgggggacg aggcggtcgg gcagtccgaa ccgctgtggc cggcctcggt ccgggcggag
     9121 accgccggcg tcgtcctggt gctgccctgg gcggccgtgc gggagctgac cgaccgggtg
     9181 ccgtccctcg acacccatct gcgggagtac gccgagcgcc aggccaggcc catgaaccgc
     9241 aagggcgagg ccgaagtacc ccttcaggcg ggccacgtgg gcgaggagac gctgcgaggc
     9301 ggcttcgtgg actacgaact cgcgccccgt gaatacgagt tgtcgctcac ccagaccgta
     9361 ctgcgggtcc acacccgcgt cgccgacctc tacaacgagc cgatggacca gaccgcggag
     9421 cagttgcggc tgaccgtgga ggagatccgc gaacggcagg agtgggagct ggtcaacaac
     9481 cgtgagttcg ggctgctcca caacatcgac tacggccagc ggatcagcac ccacagtggt
     9541 gcgccgacgc cggacgacct ggacgagctg ctgacgatgc gccgcagcac caaggtgttc
     9601 ctcgcgcatc cgaaggcgat cgcggcgttc ttccggcagt gcaaccggcg cggcctggtg
     9661 ccgggcaccg cgaacatcga cgggcgcgag gtgccggcct ggcgcggtgt gcccctcctc
     9721 ccgtgcggca agatccccgt caccgaggac cacaccagca gcatcatcgc gctgcgcacc
     9781 ggcgaggcca gtcaaggggt catcggcctg taccagaccg gcatccccga ggagtaccag
     9841 ccgggtctga acgtgcgctt catggggatc gaccgcgccg cgatcgtcaa ctacctcgtc
     9901 acggcctact actcgctggc catcctggtc cccgacgcgg cgggagtcct ggagaacgta
     9961 cagatcggcc ggacggccga gtgacggtct ggagcacgcc atgagcacat ccaccgactc
    10021 ctacgcgctg cccggcccgc ccgacatcgc ccggagcctg cgccgggagc ggcgcacagg
    10081 ggtgatcccc ggactgcacc accgcccggc cgcacccgcc gacccggcca aggcggccga
    10141 gatcgaccgc cggctggaga cctgggcacg cggcctggac ctgttccccg aagcctggca
    10201 gggagacttc tcgggcttcc agttcgggcg ggccgtcgcg ctccagcatc cgggcgccct
    10261 ggacctggaa cggctgacgg tcgcggggaa gctactgctc gcggagaacg tcgtcgactc
    10321 ctgctactgc gaggaggacg aggggcgcgg cggcgcgcgg cgcgggctcg gagcccggct
    10381 gatcatggcc cagtcggcga tcgaccccta ccacggcgtc ccggaactgg aggaggagtg
    10441 gcgcgcgggc atgcgggccg acggccccct gcgctcgtac cacttcgccc tcgccgacta
    10501 cgccggcttc gccaccccca gccagacggg ccggttcgtg cacgacatcg cccggctgca
    10561 catgggctat ctggcggagg ccgcctgggc cgagacccgg tacgtgccac gggtctggga
    10621 gtacctcgtg atgcggcagt tcaacaactt ccgcccctgt ctgtcgatcg tcgacgcggt
    10681 ggacggctac gaactgcccg agcaggtata cgcccgtccc gagatccagc gggtcaccgc
    10741 cctggcctgc aacgccacga cgatcgtcaa cgacctgtac tccttcacca aggagctggc
    10801 cagcgacccc gaccacctca acctgccgca ggtggtcgcg gccaacgacc ggcgcggact
    10861 gaaggccgcc tatctgaggt ccgtcgagat ccacaaccgg atcatggcgg ccttcgagga
    10921 ggagtccgcg ctcctctccg ccggctcgcc cctcgtggag cgctacctcc aggggctcgc
    10981 cgcctgggtg tccggcaacc acgagtggca tgccaccaac acccatcgct accacctgcc
    11041 ggactactgg tgacggcccc tcacgggcaa ccgtcaccgc tgtccctgaa caccgtcacc
    11101 cgtgccacaa ggagtcaccc ttgacgaccg tccccgcccc gaccgcaccg gccgtcgccg
    11161 tgccgacgca gtccacgtac cagcaccgcg tcgcggagta ctggaacgcc gaggagaacc
    11221 cggtcaacct cgaactcgga aaggtggacg acctctacca ccaccactac ggcatcggtg
    11281 ccgccgaccg gtcggtcctg gacgagcccg acccgggccg gcgcagggag cggatcaccg
    11341 ccgaactgca ccgcctggag cacgcccagg ccgagctgct cgccgcgcac ctcgggccgc
    11401 tctccccggc cgaccgggtc ttcgacgcgg gctgcgggcg cggcggcggc agcgtcacgg
    11461 cgcatctgcg ctacggctgc cacgccgacg gcgtcaccat ctccgccaag cagtgcgact
    11521 tcgccaacga gcaggcccgc gcccggggca tcgacgacac ggtgcgctac caccaccgca
    11581 acatgctcga caccggcttc gagacgggcg cctacgcggc gtcgtggaac aacgagtcca
    11641 cgatgtacgt cgagctggac ctgctcttcg ccgagcacgc ccggctgctg cgccgcggcg
    11701 gacggtacgt gacgatcacc ggctgctaca acaacgccta cgggcaggcc tcgcgggagg
    11761 tgtcgctgat caacgcgcac tacatctgcg acatccatcc gcgctcggag tacttcaagg
    11821 cgatggcccg caaccgcctc gtgccggtcc acgtcgagga cctcaccgcg gcgaccgtcc
    11881 cctactggga actgcgcaag gaggcggacc acctggtcac ggggatcgag gacgccttcc
    11941 tggacgccta ccgcaacggc agcttccagt acctgctcat cgtggccgac cgggtctgac
    12001 ccggacggtc cggcacgggg gcggcgacca gcggggcgcc gccccccgcc gtcgtgcggc
    12061 tccagctccg cgtgtgccga gccgtgcgct gcccggagcg cgcccgactt gaccctgaca
    12121 cagtggcaag gtttccactg gggtgctgga ggtggtcccc atcgacatga ccgctcagca
    12181 cactcgtttg ggcaaggcca tgggtgccga agacacttcg gttcggcttc aggcagccat
    12241 ggcggtcggt tcgcgcgccg atcccgtctt cctggacgct ctcgtcgagc gctgcgccgt
    12301 cgagcccgac ttcttcgtgc gggacatgct gtcctgggcc ctgacgcgtc ttcccccgga
    12361 cgtcaccctg ccccggctcc gcgaggagct gggctcctgg tgcgggcagg cccgtagcca
    12421 ggcgttgcac acgctctcca agatcgacga caagagcaca tggggctgga tcacccgtga
    12481 cctcctgcgt gacgacgacg aggtcgcgcg gaccgcgtgg cgtgcggccg tcgtgctcgt
    12541 gcccgagggg gaggagcggg gcttggccga cgagctggtc cggcagctcg ggcgcggtga
    12601 ccgggacgtg cggttgagcc tgagccgggc cctggtcgac ctcggcgagg agagccggcc
    12661 cgcgctggag cgggccgccc ggcatcccga acccggggtg gcggcgcacg cgcgggccac
    12721 cgagttgttg cggcgggacc cggaggccgg tttcgacgcg gcggtcgagg aggcgaggcg
    12781 tacggtcgtg ctcggtccga agcacggggc ggctcaggca taggagggcg tacgttgctc
    12841 atcggagagg tggcccggcg gtccggggtg agtgcgcgga tgctgcggca ctacgacgac
    12901 ctggggctgg tgcggccgac cgggcggacc gtcggcgggt atcgcgcgta ctcggccgac
    12961 gacgtccgca ggatcttcca tgtcgagagc ctgcgctccc tcgggctgtc gctcaagcag
    13021 atcaggcgcg cgctggagga cccggcgttc acaccgtccg ccctggtcgg cgacctcatc
    13081 cggtgggcgg aggaccgcct ggcgcgcgag cgggagctgc tcgaacggct tcgggtgatc
    13141 gacgcctcgg cccccgcggg ctggcaggac gtcttccgcg tcgtcgaact catgcgggaa
    13201 ctcgactcct ccagtgccgc ccgcagacag caggccgtcc tcacccggcc ggagggcgtg
    13261 ccggtgccgg cggagctact ggccggggcc gtgctgaccg agtcggaccc gcatgtcgcg
    13321 ggcgcgctgc gctgggccct ggcccggacc ggagacgacg gcgtgacggc gctggcggcc
    13381 gcagcgcgtt ccggggacgt ggaggtccgg cggcgcgcgg tactggcgat cgcggggatg
    13441 gcggaggtgc cggaggcgat cccggtgctc acggaccggc tggaggaccc cgacgcccac
    13501 gtccgcggac aggccgccct cgcgctcggc acacagggag tggcggcggc cgtacccgcg
    13561 ctcgtccgca tggtggtgga cggcaccaac gacgtggacg cggccgaggc gctgggaatc
    13621 ctctcccggg accccgcctc cgcgacccgg atcaccacgc tcctggccga ccggctggcc
    13681 gaccccaccg ccggccccgc gacccgaatc cgtctgatcc aggcgctcgt cgagctggag
    13741 ggaaccgccc ccctggagat cctgcgccgg ctcgcccgcg acgaggaccg cacagtcgcc
    13801 ctcgtcgcgt cggccctggc gggcgtcgtg gaggagcggg cccgcgaggt gctggacgac
    13861 ccgtgatggt cgcccagcac atgtgtgtca gctatacacg agcaggtagt cgcatgtgct
    13921 cgtgccgtca tggatcgacg tgtcgctgtt gaggacgtag aaggcaccgg cgaacccggt
    13981 ggcggtgatc ttcgggacca cgatgatcgt ctggtcggcc atgttcagcg agccggggcg
    14041 gacgacgttg gtgtagagca ggttgaagag gttgtcccgg aggttgggaa gccggaggac
    14101 gcggtacacg cggtcgcccg ccgagcccgt gacggcggcc tggttggccg ggttcgccca
    14161 ctgcgcgggg gatgtggcca tacggccctg tgactcgagt tcctgcaggc gccgctgcgt
    14221 gctcgcccgg acgccggcca tgtggatgtg gagctggtcg aagcgccggg cgttctgcga
    14281 gttgatgccc aggccgatgt tcgggtactg cacggggaca tcgccgccgc tgcgggcgtt
    14341 ctcccacgcc tcgtgccagt agttgggcgg gccgctggtc acgaggaacg ggcattcgat
    14401 gcccgtgaca cggcacgtcg gcagcaggag gtagttgtgc gtggtctccg gctttccgtg
    14461 cagcacgacg tagttcgcgg tcatcttcag gcagtccggc ttggtctgcg gcggcggggg
    14521 gacgatcccg ctggtgcagt actggacgtc gtgccacagc gggtcgttgt ccgtgggccg
    14581 gccgcagacg ctctggaggc tggcgggcgg gcacgagccg gtgccgcccg ggggaggcgt
    14641 ggtggggcac gagtcggggc ccggaccagc gtcggcaccg ctcgccgccg cggcggtacc
    14701 gccgcccatc gcgaccgcgc ccgtcaggac cgtcgcggcg cccagcgcac cggagagcgc
    14761 cacgaattga cgccgcggga cttccttcgc gttctgctgg tcattcatct ctgatctccg
    14821 atggaagcac cgacggggtt ctccgcagag taagtgccgg aaatcgatct gcggtgattc
    14881 cacccgtcgg ccgaatgagt gagcgtccgc aacgaccacc gggcgcggca cccggagcgc
    14941 cccggccagc cgcgggacct ggacgccggc ccggtttcgc ccactcccac cgcttcgact
    15001 actccagacg ctccgcacgc aaggccgagc gcctgagttt gccggccgcg ctgcgcagcg
    15061 gttccgtcac caactcgacc gacctgggcc gcttgtgggg cgacagccgg gtggccagga
    15121 agtcgttgat ctcctcgggg gtggtggtac gcccctcctc gatctgcacg atggcgtgga
    15181 cgcggttgcc ccggtccggg tccggcaggc cgatgaccgc gctggacagg acgtgcgggt
    15241 gctcggtgag agcgccctcg atctcggcgg ggtagacgtt caccccgccg accaggagca
    15301 tgtcggaccg gcggtcgtgg aggtacagat agccgtccgc gtcgaattcg ccgatgtcgc
    15361 cgagggtcga ccagccgtgg gtctcctgga cctcggctcc caggtatcgg aaggcgggcg
    15421 gcttgccgtc cgcgacccgc atgaagatct caccggcaac tccgggctcg gtgaccggtg
    15481 tgccgtccag ccccacgatc ttgatctcgc cccaggcggg acggcccacc gagccccggt
    15541 gcgccagcca ctccgtgccg gagatcgtgc agccggcctg ggcctcggtg cccgcgtaca
    15601 gctcccagat ccggtccgcg cccagccagt cgatccacgc ctgcttggtc gcgggcgggc
    15661 agggttcggc gcagtgccag accgagacga gggaggacag gtcgtagcgg gcgcggaccg
    15721 gttcagggag ggccaggatg cggcgcatca tggtcggcac cagatacacc cacgtgatcg
    15781 cgtgccgttc gacctcggac agcacccgct cggcgtcgaa ccgctccagg agcgtgaccg
    15841 tgccgccgtt gaacagcgtc gtcatggccg tggagaaggg ggcgttgtgg tggacggggg
    15901 cggtgacgag ggaccgctcg ccgggacgca gtccccaggc ctccatgtcg aaggggttga
    15961 acgccccctc cgcccccgac aggatgatct tcggccggcc ggtcgatccg cccgaggtgg
    16021 gcgccttcca cgacgggccg atcacggtgg tcagctcggt ggccggctcg ccctcaccgg
    16081 cgcccagccg gcgcaactcg gccacggttg tggaccggcc ggacgcaccc tcctggagac
    16141 cgatcacgac cggcggctcg gacagggcga ggatcgcccg ctcctcggcc ggtgccagcc
    16201 tggtcgacaa cggctggggc accgcgccta ttctcaggca ggcgaaggcc gccacgacga
    16261 cgtccaggcc gttcggcagc atgaggggga cgatgtgtcc gggtgtgacg ccggagagtc
    16321 tcaggccgcg cgcgacggcg tcgctcgccc ggtacagctc ctcccaggtc agttccgcgt
    16381 cgccggcgcg gaccgctgcg gagtcgcggc gttcggccgc gtaggcggcg gggatgtcgc
    16441 cgagcgggaa ccccggttgg ggggtgaaca tggctcttac tcctcgtcgt tggggaatcc
    16501 ggccggtcag gagtagagct gcgatccggg cagcgcctcg gggtcgcggc gcacctcggc
    16561 cgggttcgtc tcgggcagga accacgcggc ggcgaaggtg atcaggccca tcagggcgat
    16621 gtacacggcg accagcgtgg tcgacccggt cttcgcgatg acggtggtca tcaggatcgg
    16681 cgtgccgccg ctgaccacga tcgcggagag ctggtaggcc agagaggcgc tggagtagcg
    16741 gacgtggggc gcgaacagct cgccgaggaa ggccgccatc gggccgtacg tgagtccctg
    16801 gaagaggaag ccgaccgtga tcgcgacgaa caccagcggc gccgaggccg tattcaccag
    16861 ggcgaagtag gggaacgccc atgcggccac gccgagtccg ccgaccagga tcagcctgcg
    16921 gcggccgaag cggtcggaga ggtggcccgc gcaggggagt atcccggcca tcagggccga
    16981 gctgaacagg gtgaccgtga gcagggagtc gcggtccatg tgcagggtcg tcgtgccgta
    17041 actgagcagg ccggtgatgc tcacgtagaa gaggctgttg gtggcggaca gggtgccgca
    17101 accgagcagg atcgtgcgcc agttgcggcg tacggcctcg gtcagcgggg cccggaccac
    17161 gctcgcctcc ggcctgcggg cggcggcctc cttgagttcg cggaagtccg gggtgtcctc
    17221 gaccttgttc tggatgtgca ggacgaccgg gaacatcacc gcgctgagca ggaacgggat
    17281 gcgccagccc cagtcgagga acgcgtcgcc cgagacgagc gagccggtcg tggtgaagac
    17341 gaggttcacg atgatgaccg cgaccgggac gctcgtctgg ccgaacgtac cggcgaaacc
    17401 acgccgtttg gggtgcgccg actccgtgag cagcagcgcg atgccgcccc actggccgcc
    17461 cgccgccgcg ccctggacga agcggagcag caccagcagc actggtgcga gcgcccccac
    17521 gctcgccgcg ctcggcagac agccgatgag gaacgtcgcg gtggccatgc cgatcagaca
    17581 cgccacgacc gtgggcttgc ggccgtgctt gtcaccgaag tgaccggcga gcagcccgcc
    17641 cagcggccgg gccacgaacc ccgcccagaa ggtgctgaag gagagcagcg tgcccatgaa
    17701 cgcggacgag tgcgggaaga acacgtgcgg gaagaccagt gccgccgccg tgccgtagag
    17761 gaagaagtcg taccactcga tcgagctgcc ggtcagcccg gccgccagca gcctccagtt
    17821 ggcacggcgt acgggcgcgg tgacgggatc ggagccgttg ccctggacgt gggcctgcgc
    17881 ggatgaggcc atgggaggca tccctccggt tctggtcagg ggtatgtgcg gggacgcccg
    17941 ccggccggtc gggacatgtg ccacagctct gtgtggggtg agagtagagc tgagcaagcg
    18001 ctttgggaga tggggagtcg ctacactcct cgcacctcag aggtgggcga atccaccacc
    18061 tagcgtctcg gtgaaggcga gcgatggcac acagcgattc cgagccggcg ggcgcgggcg
    18121 gtcagggtga actcgccgcc taccggctgc gccgcgaacg cgagttgagc agcctgtacg
    18181 cgacggtccg ctcgctgacc gtgctgggcg aggtggacca ggtgctgctg tcgatcgtcc
    18241 gggaggccca cgaactgatc ggcagcgact tcgtctacct ctcgctccgc gacacggccg
    18301 gcgctctcgt cctcagcgcg tcggccggca ccatctcgtc cgagttctcc tccgcgcgca
    18361 tgcccgccgg ggccgggctc ggcggctggg tgatcgagac cagggccccc gtctgggtca
    18421 gcgactaccg ccacgccgac ggcttccacc gcgatcccgt gttcgaccgc ctcgtctccg
    18481 acgaggggct ggtggcactg ctcggcgtcc ccctcctggt cggcgagcgt gtgatcggcg
    18541 tcctcttcgc cgccgaccgc accgagcgcc cctacgagaa ggacgaggtc gccctcctca
    18601 gcgccttcgc cgatcatgcc gcgacagcgc tcaacaacgc ccggctgtac gacgagagcc
    18661 gagtggcgct ccagcggctc caggacgcct accgcgtcat cgagggccag gtcgccacga
    18721 tggagcgggc cgccgccgtg cacgaggcgc tgacccacgt ggtgctgacc gggggcggac
    18781 cgggtgacat cgcgcagtcg ctggtcgacc acctggaggg cgtgatcacc atccgggacc
    18841 gggacgacga ggtggtggcc acgcgctctc ccggggtggt gaccgcgggg gaggaccccg
    18901 gcctggaagc ggagttgctg gcgcgggcgc gccggaccgg ccggtgcgtc cacggcgagg
    18961 gaagcgacgg tacggtcctc agcgtggccg ccatccaggc cgggggcagc cacctcggct
    19021 cgctgtcgct gagacggcgc gcggccaccg agtcggcgga cgtccggatg ctggagcgct
    19081 cggcccagat caccggcctg ctcgcgctcc tgcgggacgc ccgcgtggag gccgaggagc
    19141 gggtacgggg cgaactgctc atggagttgc tgtcccaccc gccgcttcag cccgtccatc
    19201 cggcgctgcg cgaccgcgcg ctcgcccggg gcgtcgacgt cgaccggctg gacaccctgg
    19261 tcgcggccga ctgccacgac cggtccaccg ccgacgtcgt gcgcgaactg cacgccctct
    19321 cagcggagtt ctccggcctc gcgggtgaat tcctgggccg cgcgacgatg ctgctccgcg
    19381 ccgaagacgc ggagactgcg gtacggacgc tgcaccaacg gctgcgccgc aggctcggta
    19441 ccccggtgct cgtggtcgcc gaccggatca ccgggcacga ccgcgcgcac tcctacacgc
    19501 tggccgtccg ctgcctcgac gtcatgcgca gcctcggtga gaccgaccgg ggagccacga
    19561 cacggcggta cgcgatgtac gggctcgtct tcgacccgcg gcgcgcacag gagctggagg
    19621 gattcgtcac cgactccctc ggccccctcc tcgactacga ccggcgccgc gcgaccgacc
    19681 tcgtcagcac ggtcgccgcc tacttcgccc actccggaaa cctcagccgg accgcccacg
    19741 ccctccatgt gcacaccaac accctcctga agcgcctgga ccgcatcgcg gctctcctcg
    19801 gtgacgactg gcgctcggcg gactccgcgc tgagactcca cctcgcggta cggctgcacc
    19861 agttgcgggc ggtactggac gggccggggt aggtcagggc gtcgcggttc cgtcgcggtc
    19921 gcgcagggcc agcagggtcc agccgtggcc ggacgggtcg agcggcctgg tcgcggcggt
    19981 gaagagttcc gccgcccggc ggtaggagag acggccacgt ccggtcaccg ggcagcggtc
    20041 ggccgggggt gtggtcgcgg gagcccggcg ggcggtgacg aagaccgggc ccgccgtgcg
    20101 gccggcgagg aggaggggga gcagccgggc tgtgccctcg ccccaggcaa ggcgggccga
    20161 cgcgccgggt ctggtacggc gggccgggag gtccaggtgg tcgatgtcga gggcgagcac
    20221 gtgctccacg ggagctcctg actcatgcag gaagtaccag aaggccagct ctctgagggg
    20281 tgcgcgcagg gccagtgcgg ctcgggcgcg gtccgggggc cggggcgagg ccgccggaag
    20341 tggctgggcc aggtcgcggg ccgggtccgt ggtgatccag ctctgggcca gccaccaggc
    20401 gatggctgcg cggaagcagg ccaactcgcg gacgagagtg gtcgggcgtg ccgtggtgga
    20461 gcggtccgca agtgctcggc gcaggcgttc ctgagtcccc gggtcgtcga gcaccgagag
    20521 ggggacggac gggggatggg cacctctgcg ggcgcggccg gtgggggtgc gccgccccac
    20581 caggggccag gcccagccga gcagggagat gcggtagacg cggcgggacg cggggccgag
    20641 gcccgctttc gccaggtagc ggtcgacggc ggcgctgtac tcgaccgggg tcgcctggtc
    20701 ctcgctcatg gtgccccccg cagtaaatga gatttccgga cgcattcctg ggtttcgggg
    20761 gctgacctta ccatcaggcg tgttgcagta aacctgctcc atttactgcg ccgaattgct
    20821 tcaatgagag ccgtttataa aaggacggtg tttattcgag gaaaaccctt gcggtgaatt
    20881 gctcggcgca ggcagggtgc ggattcatga cactcggtac tcaccggctg cgtgtgctgc
    20941 ggcatgcccg gttccggcgc tttctgctgg ggcagaccac gtcgctcctc ggctcgggca
    21001 tgaacacgat cgccacgact ttcgccgtgc tgcggcttcc cggcggtggg gtc
//
