LOCUS       NZ_SGWQ01000004        22640 bp    DNA     linear   CON 10-APR-2024
DEFINITION  Herbihabitans rhizosphaerae strain DSM 101727 Ga0310478_104, whole
            genome shotgun sequence.
ACCESSION   NZ_SGWQ01000004
VERSION     NZ_SGWQ01000004.1
KEYWORDS    WGS; RefSeq.
SOURCE      Herbihabitans rhizosphaerae
  ORGANISM  Herbihabitans rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Herbihabitans.
REFERENCE   1  (bases 1 to 528885)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 528885)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 226.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004216555.1-RS_2024_04_10
            Annotation Date                   :: 04/10/2024 19:27:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,690
            CDSs (total)                      :: 6,628
            Genes (coding)                    :: 6,561
            CDSs (with protein)               :: 6,561
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 13 of 67
            Pseudo Genes (incomplete)         :: 59 of 67
            Pseudo Genes (internal stop)      :: 5 of 67
            Pseudo Genes (multiple problems)  :: 9 of 67
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 32502
            Orig. end                         :: 55142
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SGWQ01000004.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22640
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="1"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22640
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22640
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12640](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12640
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(292..306)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    1186..1206
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.1"
                     /tool="antismash"
     gene            1456..2190
                     /locus_tag="EV193_RS13450"
                     /old_locus_tag="EV193_10440"
     CDS             1456..2190
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657589.1"
                     /locus_tag="EV193_RS13450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10440"
                     /product="hypothetical protein"
                     /protein_id="WP_130344456.1"
                     /transl_table=11
                     /translation="MGDQLKEGLGQAWALIATFVPKLLGFLIILFIGWLIAKAVAKGLS
                     MVLNKLGFNRMMEKTGLTNMLRGSGVDAGGIIVKLAYYFILLIGLQLAFGVFGPSNPVS
                     VLLNDVIAFLPRIVVAVVLVIVAAAVAKVVRDLITSSLGNRPFAPMLGTIAYAFLIAIG
                     IIAALNQVNIATTVTMPVLITVLATVGGVIIVGFGGGLIRPMQERWGGWIDRFQGQMGA
                     PKPRAEQAPGAVRQAEAPRTQR"
     regulatory      2315..2442
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            2519..3151
                     /locus_tag="EV193_RS13455"
                     /old_locus_tag="EV193_10442"
     CDS             2519..3151
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0034257 - nicotinamide riboside
                     transmembrane transporter activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020630472.1"
                     /locus_tag="EV193_RS13455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10442"
                     /product="nicotinamide mononucleotide transporter family
                     protein"
                     /protein_id="WP_130344457.1"
                     /transl_table=11
                     /translation="MHVLMENGLTLFGQKISFAELFGQVFALAVVFLAQRRTLWTWPVQ
                     LASVVLLFAVYTSAHLGGLAIRQVVIGLIAVYGWWAWRRRRDPVFGVAVRRAGPRELII
                     AGVFLVAGTIGFALLLDATDASWAPWPDAAIFIGTVLAFALQGIGLVEFWLVWLIVDAV
                     GVPLQISSGLWFSAVVYVVFAGLVIHGWISWYRAAAQQRAAGELAAA"
     gene            complement(3137..4312)
                     /locus_tag="EV193_RS13460"
                     /old_locus_tag="EV193_10443"
     CDS             complement(3137..4312)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039696.3"
                     /locus_tag="EV193_RS13460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10443"
                     /product="DUF6236 family protein"
                     /protein_id="WP_130344458.1"
                     /transl_table=11
                     /translation="MGSIALYYPWMHFQSDDWVKLALLTWDGIVLTRPPELPSRDSELV
                     RQVRAESDLITDATPSAADLDLVGDTFGSVLDAHSKAMVERFGTQAARPARSYGNPASN
                     AGGFYAPAEPATPDDPRTFWVHHDRSAPSVGKMSAELSTRLIKAKLAVAEPNGRPWLGM
                     RPELGSIYLAVLADAMSANNALSPVTDDLRMHHALGALDQVEGLLLGGPDRTPALADAE
                     AAYVHLALRVVIEPERLAHVPTDKLIKFRAEHGAELTAFRAHVAGLGDELRAIAAVENV
                     EVAHAHLKALYERETKPKLDDLRKGLRALGVESVAGPLALKVDAAAGTVLGGLAAAGGQ
                     LAVAGAAVAVTVVPYLAGKHKARREQKKGSPVAYLLAADRRLAGASLLRRR"
     gene            complement(4317..5102)
                     /locus_tag="EV193_RS13465"
                     /old_locus_tag="EV193_10444"
     CDS             complement(4317..5102)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1260: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018334239.1"
                     /locus_tag="EV193_RS13465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10444"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_130344459.1"
                     /transl_table=11
                     /translation="MGADVRAWRVDVPGVAEVFHARYTEHAYPSHTHDVWTLLIVDDGM
                     IGYGLEHDEHDSTPNTVTLLPPHVAHDGRTVTSQGFRKRVLYLDDTVLGDELVGAAVDR
                     PTLADPLLRRRVDQLHHVLTHPGEALAGESRLALVGEALRDRLGRAEHPRPPDDGVADA
                     LRQLLDEHVVDGITLADAAGSLDTHPTHLVRSFGRAYGLPPHRYLTGRRVELARRLLLA
                     GQPAADVAITAGFYDQSHLNRHFTRMLGTTPARYAGLAR"
     gene            5101..5559
                     /locus_tag="EV193_RS13470"
                     /old_locus_tag="EV193_10445"
     CDS             5101..5559
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155248.1"
                     /locus_tag="EV193_RS13470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10445"
                     /product="DUF2000 domain-containing protein"
                     /protein_id="WP_130344460.1"
                     /transl_table=11
                     /translation="MSRTYKTGAGGGRTLEHMRFDTKIAVVLRDDLESWQRLNVTAFLV
                     SGIATNAELIGESYVDGDGAEYLPMFRQPVLVFTGGKDVLADARRRALDRGMAMSIYTH
                     DLFATGNDDDNRAAVRAVPTDSLDLVGIAVHGKRNAVDKVLKGATLHP"
     gene            complement(5651..8359)
                     /gene="aceE"
                     /locus_tag="EV193_RS13475"
                     /old_locus_tag="EV193_10446"
     CDS             complement(5651..8359)
                     /EC_number="1.2.4.1"
                     /GO_component="GO:0045250 - cytosolic pyruvate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0004738 - pyruvate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /gene="aceE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020422490.1"
                     /locus_tag="EV193_RS13475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10446"
                     /product="pyruvate dehydrogenase (acetyl-transferring),
                     homodimeric type"
                     /protein_id="WP_130344894.1"
                     /transl_table=11
                     /translation="MAAHLPDIDPDETAEWLDSFDGALATGGQQRARYLMLRLLERARE
                     SRVGVPSLTSTDYVNTIPTEQEPWFPGDEETERRFRAWIRWNAAMTVHRAQRPGVGVGG
                     HISTYASSAALYEVGFNHFFRGKDHPGGGDQIYVQGHASPGIYARAFLEGRLSAEQLDG
                     FRQEYSHAGPGGGLPSYPHPRLMPGFWEFPTVSMGLGPMNAIYQARFNRYLHARGIADT
                     TDQHVWAFLGDGEMDEPESRGLIHVAANEGLDNLTFVINCNLQRLDGPVRGNGKIIQEL
                     EAFFRGAGWNVIKVIWGREWDKLFHADRDGALVNLMNTTPDGDFQTYKANDGAFVREHF
                     FGRDPRTKELVKPMSDPEIWNLKRGGHDYRKVYAAYQAATEHHGQPTVILAKTIKGYNL
                     GPHFEARNATHQMKKMTLDDLKLFRDTLRVPISDEDLERDPYLPPYYHPGKDAPEIQYM
                     HERRRTLGGFVPERRGKSKALVLPGDKVYDVIRRGSGKQEVATTMAFVRLVRDLAKDSE
                     IGPRLVPIIPDEARTFGMDSMFPTQKIYNPLGQTYTSVDAELMLSYKESEQGQILHEGI
                     NEAGSTASFTAAGTSYATHGEPMIPIYIFYSMFGFQRTGDGLWAAGDQMARGFILGATA
                     GRTTLTGEGLQHADGHSLLLAASNPAVISYDPSWSFEIAHIVKDGLRRMYGENAEDIFY
                     YLTIYNEPYRQPAEPEDLDVEGLLRGLYRYQVAPEGPGARAQILVSGVTMPDALRAQEL
                     LAEDWGVRADVWSATSWAELRRDAVEVDRHNLLNPDAEPRVPYVTEALSEAAGPVVAVS
                     DWMRAVPDLIRPWVPTDMYSLGTDGFGFSDTRPAARRHFLVDAQSIAVGTLAALAARGE
                     IQKSLVSEAARKYRIDDVQAAGPQTSDSGSA"
     misc_feature    8431..8446
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.86"
                     /tool="antismash"
     gene            8682..9113
                     /locus_tag="EV193_RS13480"
                     /old_locus_tag="EV193_10447"
     CDS             8682..9113
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003084504.1"
                     /locus_tag="EV193_RS13480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10447"
                     /product="DUF3052 domain-containing protein"
                     /protein_id="WP_130344461.1"
                     /transl_table=11
                     /translation="MVAAGDAEKTGVAETLGINPGMVVQEVGWDEDVDDDLRTAIEERS
                     GAELLDEDADEVVDVILLWWRDDDGDLVDTLINIRPPLAEDGVIWVLTPKTGRDGHVEP
                     RDIAEAVPTAGLSQTSNVNVGDDWSGTRLVAPKSAKSRR"
     gene            9218..9682
                     /locus_tag="EV193_RS13485"
                     /old_locus_tag="EV193_10448"
     CDS             9218..9682
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099021.1"
                     /locus_tag="EV193_RS13485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10448"
                     /product="peroxiredoxin"
                     /protein_id="WP_130344462.1"
                     /transl_table=11
                     /translation="MAVEVGSKAPDFTLNDYNKQQVTLSSYQGDKNVLLVFYPFAFSGI
                     CQGELCQVRDELASYTDNNVQVVGVSVDTPFSLKAWAEQQGYEFPLLSDFWPHGKVAQE
                     YGVFNEAAGLANRGTFLIDTEGVVRFAEINQPGEARDQEAWKKAVTALSA"
     tRNA            9720..9791
                     /anticodon=(pos:42254..42256,aa:Val,seq:tac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="EV193_RS13490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="EV193_10449"
                     /product="tRNA-Val"
     gene            9720..9791
                     /locus_tag="EV193_RS13490"
                     /old_locus_tag="EV193_10449"
     gene            10001..12640
                     /gene="lanKC"
                     /locus_tag="EV193_RS13495"
                     /old_locus_tag="EV193_10450"
     CDS             10001..12640
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="EV193_RS13495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10450"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_130344463.1"
                     /sec_met_domain="micKC (E-value: 4.4e-252, bitscore: 833.8,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.2e-13, bitscore: 43.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 5.7e-05, bitscore:
                     17.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQEYQPFCLADPSFYDAMHSEDTAGESFPTARRPLPDGWRLREQ
                     DDWLVVDPPDGHQIPLQGWKIHASATTGNASVVLDAVWEYCVPRGIEFKFLRSPSALTA
                     RVAKYAPRGYSGKLVTIYPADDTACETILRELGGRLDGQESPYILSDLRWGKGPLYVRY
                     GAFANRYTVNDSGEVVEAIADPDGNLVADRRDPVFHVPSWVTLPDFLAPHLAARNATTV
                     GELPYSIERVLHFSNGGGIYVGKDQRTGEDVVLKEGRPHAGLDAWGHDAVRRLEREYET
                     LTRLAGIPGIPRVHDLFWLGEHRFLVMDYVDGDVLGKALVTRYPLIDPAAGPARFAEFT
                     DWATDIHRQVEETIAAVHERGIVYGDLHLFNVMVRPDGTAALVDFEVAAPVDESTRPGL
                     GNPGFAAPRSATGFDIDRYALACLRLALFLPMTNLLGLHRVKARHFAEIIATHFPVEPD
                     FLARAVDVIVPSNTPSTPSPKTEPDSDGWPALRNELADAIVASATPLREDRLFPGDPQQ
                     FAVGGLGLAYGAAGVLHALSVTGAGRYPELEDWLVRHATNPPTGSRLGLYDGLHGVAFA
                     LEHLGRRQEALDVVDICLRENWTTLGSDLVGGLPGMGLNLLHLADRTGEPALREAAHRA
                     AERVADRLSPDMPDDVPDYEFQSDSSAEISGGGSPLAGLLRGRAGSALLLLRLYDDTGD
                     TAYLERARVALRQDLRCCVLRDNGVLEVNEGWRTMPYLDGGSIGIGMVLDEYLRRCPDE
                     HFALANRGVEMAARSTMYILPGLFTGRAGVVLYLAGRSPSPVTDPLVAKQVRALAWHAL
                     PYGGGMAFPGTALLRLSMDLATGTAGVLLAMGAALHDQPVRAPLLTLARDPAPKTPTAT
                     VVGLERQF"
     misc_feature    11513..11515
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12650..12799
                     /locus_tag="EV193_RS13500"
                     /old_locus_tag="EV193_10451"
     CDS             12650..12799
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="EV193_RS13500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10451"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_130344464.1"
                     /transl_table=11
                     /translation="MALLDLQGMDAAPQHGHGGGSSASGHSCPSNLSVTLCGGTSGLSL
                     LICH"
     CDS_motif       12650..12712
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGMDAAPQHGHGGGS"
                     /locus_tag="EV193_RS13500_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12713..12799
                     /prepeptide="core"
                     /locus_tag="EV193_RS13500_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.40"
                     /molecular_weight="2539.9"
                     /monoisotopic_mass="2538.3"
                     /core_sequence="SASGHSCPSNLSVTLCGGTSGLSLLICH"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGMDAAPQHGHGGGS"
                     /leader_location="[12649:12712](+)"
                     /alternative_weights="2557.9"
                     /alternative_weights="2575.9"
                     /alternative_weights="2593.9"
                     /alternative_weights="2611.9"
                     /alternative_weights="2630.0"
                     /alternative_weights="2648.0"
     gene            12877..14523
                     /locus_tag="EV193_RS13505"
                     /old_locus_tag="EV193_10452"
     CDS             12877..14523
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076000.1"
                     /locus_tag="EV193_RS13505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10452"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_130344465.1"
                     /transl_table=11
                     /translation="MSTFRATARRAGSWLPLLGLSALAGTLSLLALPVVLGNTVDAIVS
                     NADSLRWLALAAALIGVGVAADLIDAYAGAACVAGTTAWLRDRLVGHVLAVGPHGGRRL
                     DTGDLVSRVSGNAAEAAQAGPSVVAVVAAVLPPVGSLVLLALIDLWLAVAFLAGLVLVA
                     VILRVFTRQTAEVVSAYLRAQGRIAGRLSESLAGVRTIAAAGTVELEERRVLEHLPELH
                     RQGVRSWRVLSRSSAQAAVVGPLVLVAVLATGGVALSAGRISPGELFAASQYAVIGAGL
                     GGLTGMFGRLARSKAGAARVGEVLDLDPVRHGGRTLPEGTGRLEFRGVTVRAGDVPLLD
                     GVDLVVPGGSTVAVVGPSGAGKSVLTAVAARLCDPDEGTVLLDGVPLDELCHEALRTAV
                     GCAFDRPVLVGATVADAIGSRWSPEQVEAAARATYSHDFVSRLPHRYATPLTDAPMSGG
                     ELQRLGLARAWRAERLLVLDDATSSLDTVTEMRIGQTLIGDGGRTRLVVTHRASTAARA
                     DLVVWLAGGRVRAVGTHEQLRDEPDYREVFG"
     gene            14520..16217
                     /locus_tag="EV193_RS13510"
                     /old_locus_tag="EV193_10453"
     CDS             14520..16217
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009075999.1"
                     /locus_tag="EV193_RS13510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10453"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_130344466.1"
                     /transl_table=11
                     /translation="MRRELRVAARSLRRRPLLALVAASVPEALPAAVSGLVVARAVDQG
                     FLAGAPGTGLAWLGVLLVTAAVGAVGTRAVFHRLGDLTEPFRDDLVRRVVGGALRNGVA
                     GRADQGALARLTRQVEIVRDTYAGLLVAVRGFVVTAIGVLVGLLSIAPSVALLILPPFL
                     LGLVAFLATLGFAANRQRASVLADERLADVAQAVLRGTRDVVATGRERHASGMVAEAVA
                     EQAAAERALAGVAALRTACFVIGGWGPLLVLLFAGPWLAGQGLTAGAILGGLTYVLFGL
                     QPALQNFVGVVGGSGLRFVVTLGRLLDASAPPPDTRAGHGVPAGHDVELRGVTFAYGPH
                     AEPVVHDLSLTVSPGEHLAVVGPSGIGKSTLAALMCGLVRPDEGTVRHGGLPADAVSPA
                     ARVLIPQEAYVFAGTCWANLTYLSPDATTGQVDDAVEALGATALLTRLGGYSANVRPAE
                     LSAGERQLFALVRAYLAAAPLVVLDEATCHLDPIAERTVEEAFARRGGTLVVIAHRVSS
                     ALRADRILVLDGTEGTVGDHTTLVASSALYRDLVGHWVAGRPQDIVVS"
     gene            complement(16227..16802)
                     /locus_tag="EV193_RS13515"
                     /old_locus_tag="EV193_10454"
     CDS             complement(16227..16802)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012422.4"
                     /locus_tag="EV193_RS13515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10454"
                     /product="response regulator transcription factor"
                     /protein_id="WP_165401346.1"
                     /transl_table=11
                     /translation="MDLLRAALVSLLSDEDDIEVVADVKHLDTVMPVARRLRPDVAVLA
                     DLPHPQCLSTVRGLRDEVPECGIVALIVTKPPDLVSHLIELEVGGLIDKDAPPVRLLQA
                     IRKVADGESMIDTNLVVAALSATRNPLTPRERQTLQLAADGASGPEIAKSLALSPGTVR
                     NYLSKAMCKTGGRTRIQAIQIATDAGWL"
     misc_feature    complement(17077..17092)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.28"
                     /tool="antismash"
     gene            17246..18283
                     /locus_tag="EV193_RS13520"
                     /old_locus_tag="EV193_10455"
     CDS             17246..18283
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010695473.1"
                     /locus_tag="EV193_RS13520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10455"
                     /product="saccharopine dehydrogenase NADP-binding
                     domain-containing protein"
                     /protein_id="WP_130344468.1"
                     /transl_table=11
                     /translation="MAWMVYGANGYTGKLVAELAVKRGELPVLAGRTAAKVAPLADELG
                     LEYRIFDLGDPTAVRDGLDGMTTVAHCAGPFSATAAPMVDGCLAAGTHYVDITGEVDVF
                     EAIFARNADAERAGVVLLPGAGFDVVPSDCLAAMLAGELPDATELDLAFVAGGGISPGT
                     LRTTVEGMGTGGRARVDGKLVTVPVAHRSTVAELPSGPKTVVSIPWGDLATAYRSTGIP
                     NITTFTRVPAPPKAIAAGQRLFGPIMRSSAGQRVAKNLVGRIPGPSEKRRAGSRTELWG
                     RVRDANGRSVSRTLVVPNTYTFTADAVVRVVERLGKGGTPAGAHTPSSAFGADFVRGLD
                     GVTVG"
     gene            complement(18288..19022)
                     /locus_tag="EV193_RS13525"
                     /old_locus_tag="EV193_10456"
     CDS             complement(18288..19022)
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1188: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423092.1"
                     /locus_tag="EV193_RS13525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10456"
                     /product="DedA family protein"
                     /protein_id="WP_130344469.1"
                     /transl_table=11
                     /translation="MSVVADVLNWLRELPPAGVTAAAGVLVFGECTLGLGFIAPGETGL
                     FILGTTVDSTPKFLIMWLVTSICAIAGQSVGFFIGKFFGPKIRKSKLVEKHGANGWDKA
                     TDVLRRRGSWAVLIAIFLPVMRTLVPAAAGASGLPFRKFFPAVAVGATAWCALHIGIGA
                     AAGEAAEQVEKAVGNASWIILGVIAVLVILFILRKRKKAKAAEENDQTPTGDAADVPTG
                     GGAVVAATAAGEESDPKLKPTP"
     misc_feature    18988..19001
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.67"
                     /tool="antismash"
     gene            complement(19146..20147)
                     /gene="lipA"
                     /locus_tag="EV193_RS13530"
                     /old_locus_tag="EV193_10457"
     CDS             complement(19146..20147)
                     /EC_number="2.8.1.8"
                     /GO_function="GO:0016992 - lipoate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0009107 - lipoate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lipA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943936.1"
                     /locus_tag="EV193_RS13530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10457"
                     /product="lipoyl synthase"
                     /protein_id="WP_130344470.1"
                     /sec_met_domain="PF04055 (E-value: 1.5e-14, bitscore: 49.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTPEGRKLLRLEVRNSETPIERKPSWIKTRAKMGPEYTELKSL
                     VKREGLHTVCEEAGCPNIFECWEDREATFLIGGDQCTRRCDFCQIDTGKPAALDRTEPR
                     KVAESVQAMGLRYSTVTGVARDDLADGGAWLYAETVRQIHELNPGTGVELLIPDFNADP
                     DQLAEVFGSRPEVLAHNLETVPRIFKRIRPGFRYERSLDVITRAREFGLVTKSNLILGM
                     GETPDEVTEALQDLHDAGTDIITITQYLRPSLRHHPIDRWVKPEEFVRHKESAEKIGFA
                     GVMAGPLVRSSYRAGRLYAQAKAHRGEEVPENLRHLVESGPARQEIGSILSR"
     gene            complement(20192..21133)
                     /locus_tag="EV193_RS13535"
                     /old_locus_tag="EV193_10458"
     CDS             complement(20192..21133)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (15-177). E-value: 1.3e-11.
                     Score: 36.7. Matches aSDomain:
                     nrpspksdomains_EV193_RS13535_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013224044.1"
                     /locus_tag="EV193_RS13535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10458"
                     /product="oxidoreductase"
                     /protein_id="WP_130344471.1"
                     /transl_table=11
                     /translation="MTRWSEADIPDQTGKTVLITGANSGLGLRSAIVLAGKGAKVLLAC
                     RSPERGEDAVHQVRDIGGEAELIQLDLADLSSVRAAAAEVRDKTGDTLHVLMNNAGVMA
                     TPNRKTADGFELQLGTNHLGHAALTWLLAPALRATPGARVVTLSSVAHRGGGLDVDDLN
                     FERRRYTSGSAYSQSKMANLLFAFELDRRARAAELDLASIAAHPGVTDTELAANSMRSR
                     GTGMVNNVLTMAFDFGYKVVSQSVKRGALPQLYAATVADVRGGDFIGPTGPGEFFGTPG
                     HVKARRAATSTELAGTLWDRTAELTGITPDPA"
     aSDomain        complement(20603..21088)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV193_RS13535_PKS_KR.1"
                     /evalue="1.30E-11"
                     /label="EV193_RS13535_PKS_KR.1"
                     /locus_tag="EV193_RS13535"
                     /protein_end="177"
                     /protein_start="15"
                     /score="36.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TVLITGANSGLGLRSAIVLAGKGAKVLLACRSPERGEDAVHQVRD
                     IGGEAELIQLDLADLSSVRAAAAEVRDKTGDTLHVLMNNAGVMATPNRKTADGFELQLG
                     TNHLGHAALTWLLAPALRATPGARVVTLSSVAHRGGGLDVDDLNFERRRYTSGSAYSQ"
     CDS_motif       complement(21005..21088)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EV193_RS13535_0001"
                     /evalue="2.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="EV193_RS13535"
                     /protein_end="43"
                     /protein_start="15"
                     /score="13.9"
                     /tool="antismash"
                     /translation="TVLITGANSGLGLRSAIVLAGKGAKVLL"
     misc_feature    21090..21105
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.74"
                     /tool="antismash"
     gene            complement(21154..21675)
                     /locus_tag="EV193_RS13540"
                     /old_locus_tag="EV193_10459"
     CDS             complement(21154..21675)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020671429.1"
                     /locus_tag="EV193_RS13540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10459"
                     /product="hypothetical protein"
                     /protein_id="WP_130344472.1"
                     /transl_table=11
                     /translation="MSWNDYYRRRDALDAVIQHATRNPGGGLPFDEVPGVSEIFSGPDE
                     LLAALHYRWTLKLTARVDMALAEADRDSSIDRVEAVTEAWHKAADENSALRAILDTNSD
                     RVGGTFGRAVRAEQRMLALTAGLAEITEPDEEITRVGVAFNALLHSVPQRPARRRNPVE
                     QLLRRLVPSA"
     misc_feature    complement(21788..21803)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.36"
                     /tool="antismash"
     misc_feature    complement(21798..21808)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            21804..22406
                     /locus_tag="EV193_RS13545"
                     /old_locus_tag="EV193_10460"
     CDS             21804..22406
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015099027.1"
                     /locus_tag="EV193_RS13545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_10460"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_130344895.1"
                     /transl_table=11
                     /translation="MRSRRADYSESTRQALVDSAVELFTKRGYAATSLDAVTKRARVTK
                     GALYHHFSGKQALFEAAFSAVETAVLKRLGEVAVAGPGSPWDRAMRGVEAYVQACLEPA
                     YQRIVIHEGPVVMGWERWREAEDHFSYGLIRTVIQSLIEAKEIVELPVEVTARMLFGAL
                     SSGATFLANATDPKKASAEVSNAITQVLTGLRIKKDD"
ORIGIN
        1 tgcgggcgca gttctccagc acgccgccgg cctccagata cgcctccacc gtcgcgagca
       61 gcgcgccacc ggcgtcctcc agtggcttgg cgatccggtc gatcagctgc cattccgcct
      121 ccggatcacc ggccaacgcg cgttccggca gcagatcgtg cgaccggacc gggcgcggcg
      181 cggtcggcca cccgaccacg gcacgcaggc cggacagcgc gtccgccgcg ctgcggtgcg
      241 cctcggcgag gctggccacg gtcgggccgg ccaccaccgg gccgtccccg aaggccgagg
      301 cgatccggct cagcacctgc tcgtccggcc cgtccgcggc cggtccggcg agcacgatga
      361 ccagccggga gccctgcacg ccgagcagcg ccggcctggc cagccgcgcc gcgcggctgc
      421 gcacctcgaa caccacggtc ggcgggtcgt cggacggcga gttgcccacc agcacggtgg
      481 cctgggcggc cgggtcccag ccgagtgcgg ccgcgcggga gaacaccgac tcctcggcct
      541 cgccgcgcac gatcccgtcc acgaccagag cttccagccg ggcgtcccag gcacccctgc
      601 tctcggcggc cgacgcgtag gacatcgccg aggcgaacgc gacctcgcgg ctgtaccgca
      661 gcaccgcctc ggccaggatg tcgcgctcct tgtcgtcggc ggccagatcg ggcacctgcc
      721 gctcgaacac ctgcagcgcg acccgcacca gttcgacggt ctgccgcagg ctgatccagc
      781 gggcgaggtc gcgtggggcg gcgcggaaca cgtcggtggt cagccgcagg gcctcgcgct
      841 cgtcgcgcag ccaggccgcg aagccggaga ctccgttctg ggtgatcagc aggacgctcg
      901 cgcgctggtc cgccggcatg cggccgaacc aggcgaactc ggcgtccatc gcggcgatgc
      961 tggccgaggc gagtttgccg gacgcgcggt cgagcgcggc cagcgtcttg tcggacaggc
     1021 cgctgtgccg accactccgc tcgccggatc tcccgctgct cataccgcca gaatcgcacg
     1081 tcgacccggt cgccggcgaa acggtgccgc gactacggac ggaccgttca ttgtgcgaca
     1141 gccggtaaat acgcgccact cgagaacgcc gtcgtgtgct cctcattctg gtgaatgcgc
     1201 cgataatcac tcggaacggg taccccaagg tcagcgagaa tagcgcagaa ggagggccgc
     1261 ctgacacctc gaggaagtgt gcgatgccag gcggcccgtt ccccggtccc caccggtccc
     1321 tccactatgg acggtccgcg agcctctcgc cagcgatatc ccccattcgt ggcatcacct
     1381 tcgagttgcg ggcaatcaga acctgagaaa cgctcgtcgc gacttgaaca tcagtcgctg
     1441 gacctaggag gcaacgtggg cgaccagctg aaggaaggcc tcgggcaggc gtgggcgctg
     1501 attgccacgt ttgtgccgaa gctgctcgga ttcctgatta ttctgttcat cggatggttg
     1561 atcgccaagg cagtcgccaa gggattgtcg atggtgctca acaagctcgg attcaatcgc
     1621 atgatggaga agaccgggct gacgaacatg ctgcgcgggt ccggagtgga cgccggcggc
     1681 atcatcgtca agctcgcgta ctacttcatc ctgctgatcg gcctgcagct cgcgttcggc
     1741 gtgttcgggc cgagcaaccc ggtcagcgtg ctgctgaacg acgtgatcgc cttcctgccg
     1801 cgcatcgtgg tcgcggtcgt gctggtgatc gtggcggccg cggtggccaa ggtggtccgg
     1861 gacctgatca cgagttcgct gggcaaccgg ccgttcgcgc cgatgctcgg caccatcgcg
     1921 tacgcgttcc tgatcgccat cggcatcatc gcggcgctga accaggtcaa catcgccacc
     1981 acggtgacca tgccggtgct gatcaccgtg ctcgccacgg tcggcggtgt gatcatcgtc
     2041 ggcttcggag gcggcctgat ccgcccgatg caggagcggt ggggcggctg gatcgaccgg
     2101 ttccagggcc agatgggcgc gcccaagccg cgcgccgagc aggctcccgg tgccgttcgg
     2161 caggcggagg cgccgcgcac gcagcggtga tctgatcgac gattcgacgg gcccggtggg
     2221 ggtgatcacc ccgccgggcc cgctcgcgtc tggttggtca caaacccgcc cgggaacatg
     2281 atcggcgggt gcactgttgt gccacagcaa ggagaagtgc gctccggggt cggtgaaatt
     2341 ccgaaccggc ggtgaaagcc cgcgacccgt ctgccacggc aggcggttga accggtggaa
     2401 ctccggtgcc gacggtgaca gtccggatgg gaggacgcgt acgccgccgg ccgcgtgctg
     2461 gcgcctgcgt tcttcccgtc gcgcccgatg agtgtgcgcc ggcgcgacgg aggacgcgat
     2521 gcacgttctg atggagaacg gtctcacgct gttcgggcag aagatcagct tcgccgagct
     2581 gttcggccag gtgttcgcgc tggccgtggt gttcctggcg cagcgaagga cgctgtggac
     2641 ctggccggtg cagctcgcct ccgtggtgct gctgttcgcg gtctacacct cggcgcacct
     2701 gggcgggctg gcgatccgtc aggtggtgat cggcctgatc gcggtgtacg gctggtgggc
     2761 ctggaggcgt cggcgtgatc cggtgttcgg ggtcgccgtc cgccgcgccg gtccgcgcga
     2821 gctgatcatc gccggcgtgt tcctggtcgc cggcacgatc gggttcgcgc tgctgctgga
     2881 cgccaccgac gcgtcctggg caccgtggcc ggacgcggcg atcttcatcg gcaccgtgct
     2941 tgcgttcgcg ctgcagggca tcgggctggt cgagttctgg ctggtgtggc tgatcgtgga
     3001 cgcggtcggc gtgccgctgc agatctcctc cggcctgtgg ttcagcgcgg tggtctacgt
     3061 ggtgttcgcc gggttggtga tccacgggtg gatcagctgg taccgggcgg cggcgcagca
     3121 gcgtgccgcg ggtgagctag cggcggcgta gcagggacgc gccggccagg cgacgatcgg
     3181 cggccagcag gtacgcgaca ggtgagccct tcttctgctc gcggcgcgcc ttgtgcttgc
     3241 cggcgaggta cggcaccacg gtcaccgcga cggcggcgcc cgccaccgcc agttgaccac
     3301 cggcggcggc gagaccgccg agtacggtgc ccgccgcggc gtcgactttg agcgcgagcg
     3361 gcccggcgac cgactcgacg ccgagcgcgc gtaggccctt gcgcaggtcg tcgagcttcg
     3421 gcttggtctc tcgttcgtac agcgccttga gatgagcgtg cgccacctcg acgttctcca
     3481 ccgcggcgat cgcgcgcagc tcgtcgccga gccccgccac gtgcgcccgg aacgcggtca
     3541 gctccgcgcc gtgctcggct cggaacttga tcagcttgtc cgtggggacg tgggcgaggc
     3601 gctccggctc gatcaccacc cgcagcgcga ggtgcacgta cgcggcttcg gcgtccgcca
     3661 gtgcgggcgt gcggtcgggt ccgccgagca gcagcccttc cacctgatcc aacgcgccga
     3721 gcgcgtggtg catccggagg tcgtcggtca cgggggacag cgcgttgttc gcgctcatcg
     3781 cgtcggcgag cacggcgagg tagatcgacc ccagctccgg ccgcatgccc agccacggcc
     3841 gtccgttcgg ctcggccacg gccagcttgg ccttgatcaa ccgggtgctc agctcggcgg
     3901 acatcttgcc tacggacggc gcggacctgt cgtggtggac ccagaaggtg cgcgggtcgt
     3961 cgggcgtcgc cggctcggcc ggcgcataga agccgccggc gttgctggcc ggattgccgt
     4021 agctgcgcgc cggccgggcg gcctgcgtgc cgaagcgttc gaccatcgcc ttgctgtgcg
     4081 cgtcgagcac cgagccgaag gtgtcgccga cgaggtccag gtcggccgcg ctcggcgtcg
     4141 cgtcggtgat caggtcggac tcggcgcgca cctggcgcac cagctcgctg tcccgcgacg
     4201 gcaactcggg cggccgggtc agcacgatgc cgtcccaggt gagcagtgcg agcttcaccc
     4261 agtcgtcgga ctggaagtgc atccacgggt agtacagcgc gatcgacccc atgtgatcag
     4321 cgtgccaggc cggcgtacct ggcgggggtg gttccgagca tccgggtgaa gtgccggttg
     4381 aggtgcgact ggtcgtagaa gccggcggtg atcgccacgt cggcggccgg ctgaccggcg
     4441 agcagcagcc gccgtgccag ttcgacccgg cgcccggtca ggtagcggtg cggcggcagc
     4501 ccgtaggcgc ggccgaacga gcgcaccagg tgcgtcggat gcgtgtcgag cgagccggcc
     4561 gcgtcggcca gcgtgatccc gtccaccacg tgctcgtcga ggagttggcg cagcgcgtcg
     4621 gccacgccgt cgtcgggcgg ccgcgggtgc tcggcccgcc cgagccggtc ccgcagcgcc
     4681 tcgccgacca gcgccagccg ggactcgccg gccaacgcct cgccggggtg cgtcagcacg
     4741 tggtgcagct ggtcgacccg gcggcgcagc agtggatcgg cgagcgtcgg ccggtccacc
     4801 gcggcgccga ccagctcgtc gccgagcacg gtgtcgtcca ggtacagcac gcgcttgcga
     4861 aacccttggg aggtcacggt tctgccgtcg tgcgccacgt gcggcggcag cagtgtgacg
     4921 gtgttcgggg tggagtcgtg ctcgtcgtgc tccagtccgt agccgatcat gccgtcgtcc
     4981 acgatcagca gcgtccatac gtcgtgcgtg tggctcgggt aggcgtgctc ggtgtaccgg
     5041 gcgtggaaca cctcggccac gcccggaacg tccacccgcc acgcgcgaac gtcggcgccc
     5101 atgtcaagaa cgtacaagac gggggcgggc ggcgggcgca cgctggagca catgcgcttc
     5161 gacaccaaga tcgccgtcgt gttgcgggac gacctggaga gctggcagcg gctgaacgtg
     5221 accgcgttcc tggtcagtgg gatcgccacg aacgccgagc tgatcggcga gtcctatgtg
     5281 gacggtgacg gcgcggagta cctgccgatg ttccggcagc ccgtgctggt gttcaccggc
     5341 ggcaaggacg tgctcgccga cgcgcgccgg cgcgcgctgg accgcggcat ggccatgtcg
     5401 atctacacgc acgacctgtt cgccacgggc aacgacgacg acaatcgcgc cgccgtgcgc
     5461 gccgttccga ccgattctct ggacctggtc gggattgccg tgcacggcaa gcgcaacgcc
     5521 gtcgacaagg tcctcaaggg cgcgacgttg cacccgtgaa cccgcgagtt ccgcgccctg
     5581 caccggcgag tcccgcgtcc tgcacgatgc agggcgcggg actcaccgtg tctgagcgcg
     5641 gaactcgcga ttacgccgag ccggagtcgc tggtttgcgg gccggctgcc tggacgtcgt
     5701 cgatgcggta cttgcgtgcc gcctcggaca ccagcgactt ctggatctcg ccacgcgcgg
     5761 ccagtgcggc cagcgtgccg accgcgatcg actgggcgtc caccaggaag tgccgccgcg
     5821 cagccggacg cgtgtcggag aacccgaacc cgtccgtgcc cagcgagtac atgtcggtcg
     5881 gcacccatgg gcggatcagg tccggcaccg cgcgcatcca gtccgacacc gccactaccg
     5941 ggccggccgc ctcggacagc gcctcggtca cgtacggcac ccgcggctcg gcgtccgggt
     6001 tcagcaagtt gtgccggtcg acctccaccg cgtcgcgccg cagctccgcc cacgacgtcg
     6061 ccgaccacac gtcggcccgc acgccccagt cctcggccag cagctcctgc gcccgcagcg
     6121 cgtccggcat ggtcacgccg gagaccagga tctgcgcccg cgcgcccggc ccctccggtg
     6181 ccacctggta gcggtacagc ccgcgcagaa gtccttccac gtcaaggtct tccggctcgg
     6241 cgggctgccg gtacggctcg ttgtagatgg tcaggtagta gaagatgtcc tcggcgttct
     6301 cgccgtacat ccggcgcagg ccgtccttga cgatatgcgc gatctcgaac gaccacgacg
     6361 ggtcgtagga gatcaccgcc gggttgctcg ccgccagcag cagcgagtgc ccgtcggcgt
     6421 gctgcaggcc ctctccggtc agcgtggtgc ggccggccgt cgcgcccagg atgaacccgc
     6481 gggccatctg gtcgccggcc gcccacagcc cgtcgccggt gcgctggaac ccgaacatcg
     6541 agtagaagat gtagatcggg atcatcggct cgccgtgcgt ggcgtacgac gtgccggcgg
     6601 cggtgaacga cgcggtcgag ccggcctcgt tgatgccctc gtgcaggatc tgcccctgct
     6661 cgctttcctt gtaggacaac atgagttcgg cgtccaccga ggtgtaggtc tgcccgagcg
     6721 ggttgtagat cttctgcgtc gggaacatcg agtccatgcc gaacgtgcgc gcctcgtccg
     6781 ggatgatcgg caccagccgc ggtccgatct cggagtcctt ggcgaggtcg cgcaccaggc
     6841 gcacgaaggc catcgtggtg gcgacctcct gcttgcccga tccgcgccgg atcacgtcgt
     6901 agaccttgtc gccgggcagc accagcgcct tggacttgcc gcgccgctcc gggacgaacc
     6961 cgccgagcgt gcgccggcgc tcgtgcatgt actggatctc cggcgcgtcc ttgccggggt
     7021 ggtagtacgg cggcaggtac gggtcgcgct ccaggtcctc gtcgctgatc ggcacgcgca
     7081 gggtgtcccg gaagagcttg aggtcatcca gggtcatctt cttcatctgg tgcgtggcgt
     7141 tgcgtgcctc gaagtgcggg ccgaggttgt agcccttgat cgtcttggcc aggatcacgg
     7201 tcggctggcc gtggtgctcg gtggccgcct ggtaggccgc gtacaccttg cggtagtcgt
     7261 ggccgccgcg cttgaggttc cagatctccg ggtcgctcat cggcttgacg agctccttgg
     7321 tgcgcggatc gcgcccgaag aagtgctcgc gcacgaacgc gccgtcgttg gccttgtagg
     7381 tctggaagtc gccgtccggc gtggtgttca tcaggttgac cagcgcgccg tcgcggtcgg
     7441 cgtggaacag cttgtcccac tcgcggcccc agatgacctt gatcacgttc cagcccgcgc
     7501 cgcggaagaa cgcctccagc tcctggatga tcttgccgtt gccgcgcacc gggccgtcca
     7561 gccgctgcag gttgcagttg atcacgaagg tgaggttgtc caggccctcg ttcgcggcca
     7621 cgtggatcag cccgcgcgac tccggctcgt ccatctcgcc gtcgccgagg aaggcccaca
     7681 cgtgctggtc ggtggtgtcg gcgatgccgc gggcgtgcag gtaccggttg aatcgcgcct
     7741 ggtagatcgc gttcatcggg ccgaggccca tggacaccgt gggaaattcc cagaagcccg
     7801 gcatcagcct cgggtgcggg taggaaggca gcccgccgcc cggtccggcg tgcgagtact
     7861 cctgccggaa gccgtccagt tgctcggccg acagccgtcc ctcgaggaac gcgcgtgcgt
     7921 agatgccggg ggaggcgtgg ccctgcacgt agatctggtc acccccgccg gggtgatctt
     7981 ttccacggaa gaagtggttg aagccgacct cgtagagcgc cgcggaggag gcgtaggtgg
     8041 agatgtgccc gccgaccccg accccggggc gctgcgcgcg gtgcacggtc atcgccgcgt
     8101 tccacctgat ccaggcgcgg aaccggcgct cggtctcctc gtcaccgggg aaccagggct
     8161 cctgctcggt ggggatcgtg ttgacatagt cggtgctggt cagcgacggg acgccgaccc
     8221 ggctctcccg tgcgcgctcg agcagccgca gcatcagata gcgggcgcgc tgctggccgc
     8281 cggtggcgag tgcaccgtcg aaggagtcca gccactcggc ggtctcgtcc ggatcgatgt
     8341 ccggaaggtg ggcggccatg ccgtcgcgga tgacccgcac gcgctcgggc tgagctgggc
     8401 cggtgcctgg attcgaggac aagggatctc ctggccaact ggtcggtcat tgacgactcg
     8461 tgtgggtgta cacaaccacc gtagaaccat cgtcgtcgtg atcaccgtcg acgtcatcct
     8521 tactggtcag tagccacgtt gcggtcgaag ttccggcgtg tcgcgctgca cacggttgcg
     8581 caggtgggta ccgccagtgt tcgcttacca cccaaggacc ggtagttggc acgcggccac
     8641 tgttgagcgg ggccgcgtca acccattgga ggagtgaagt cgtggtcgcc gcgggagacg
     8701 ccgaaaagac cggcgtcgcc gagacgctcg gaatcaaccc gggcatggtg gtccaggagg
     8761 tcgggtggga cgaggacgtc gatgacgacc tccgcaccgc gatcgaggag cgcagtggag
     8821 cagagctgct cgacgaggac gcggatgagg tggtggacgt catcctgctg tggtggcggg
     8881 acgacgacgg agaccttgtc gacacgctga tcaacatccg gccgccgttg gccgaggatg
     8941 gcgtgatctg ggtgttgacc ccgaagacgg gccgtgacgg gcacgtcgag ccgcgggaca
     9001 tcgccgaggc cgtgccgacc gccggactgt ctcagacatc caacgtcaac gtgggcgacg
     9061 actggtcggg aacccggctg gtggcaccga aatccgccaa gagccgtcgc tgaccctgcg
     9121 cgtccgggtg acataggctg gggtcgcggt ggctcgctgg ttgtcggcga ggccgcgtga
     9181 ttcgcaggca agctgacacc caggaggagc acgcgcaatg gcggtcgagg tcggttcgaa
     9241 ggccccggat ttcaccctca acgactacaa caagcagcag gtgacgctgt cgtcctacca
     9301 gggcgacaag aacgtgctgc tcgtgttcta cccgttcgcg ttcagcggca tctgccaggg
     9361 cgagctgtgc caggtgcgtg acgagctggc gtcctacacg gacaacaacg tccaggtcgt
     9421 cggcgtgtcc gtggacaccc cgttcagcct caaggcgtgg gctgagcagc agggctacga
     9481 gttcccgctg ctcagcgact tctggccgca cggcaaggtc gcccaggagt acggcgtgtt
     9541 caacgaggcc gccggtctcg cgaaccgcgg cacgttcctg atcgacaccg agggcgttgt
     9601 ccggttcgcc gagatcaacc agcccggcga ggcccgtgac caggaggcct ggaagaaggc
     9661 ggtcaccgcg ttgtcggctt gatcttgtcg gtgcgccgcc accgccgccg gcgcacctcg
     9721 ggcgcttagc tcagcgggag agcactcggt ttacacccga gcggtcgtag gttcgattcc
     9781 tacagcgccc actccagagt tcgttcatca cgagtgtgcg cgtcgcctcg tctgcctcgt
     9841 tcgattccgc cgcggcacgt ctcgcccgtc ccggccaagc gtttgtcacc gggtgcgtga
     9901 tgacaggtgc gtggctggtc ggtgacgttg tgctctgact ggcacaccgg tcttcgacgc
     9961 aggatgactg cggcctgttg atcgaacctc ggggtggcag atggagcagg agtatcaacc
    10021 tttctgtcta gcggatccct cgttctacga cgcgatgcat tccgaggaca ccgccggcga
    10081 gtcgttcccg accgcccggc gcccgctgcc ggacggctgg cggctgcgcg agcaggacga
    10141 ctggctggtc gtcgacccgc cggacgggca ccagattccg ttgcagggct ggaagatcca
    10201 cgcctcggcc accaccggca acgcgagcgt ggtgctggac gccgtgtggg agtactgcgt
    10261 accccggggc atcgagttca agttcctccg atcgccgtcc gcgctcaccg cacgggtggc
    10321 gaagtacgcc ccgcgcggct acagcggcaa gctggtgacg atctacccgg ccgacgacac
    10381 cgcctgcgag acgatcttgc gggagttggg tggacggctc gacggccagg agagcccgta
    10441 catcctcagc gatctccgtt gggggaaggg cccgctgtac gtgcgctacg gtgcgttcgc
    10501 caaccggtac acggtgaacg acagcggcga ggtggtggag gccatcgccg acccggacgg
    10561 caatcttgtc gcggaccgcc gcgatcccgt cttccacgtg ccgtcgtggg tcacgctgcc
    10621 ggactttctg gcgccacacc tggccgcgcg caacgcgacc acggtcggcg agttgccgta
    10681 ctccatcgaa cgggtgctgc acttctccaa cggcggcggc atctacgtcg gcaaggatca
    10741 gcgcaccggc gaggacgtcg tactcaagga gggccgcccg catgccgggc tggacgcctg
    10801 ggggcacgac gcggtgcggc gcctcgagcg cgagtacgag acgctgacgc ggctggccgg
    10861 catcccgggg attccccgcg tgcacgacct gttctggttg ggggagcaca ggttcctcgt
    10921 gatggactac gtcgacgggg acgtgctcgg caaggcgctc gtcacgcgct acccgctgat
    10981 cgatcccgcc gccggccccg cgcggttcgc cgagttcacc gactgggcca ccgacatcca
    11041 ccgccaggtc gaggagacca tcgccgcggt gcacgagcgt ggcatcgtct acggcgacct
    11101 gcacctgttc aacgtcatgg tccgcccgga cggcacggcc gcactggtgg acttcgaggt
    11161 ggccgcgccg gtcgacgagt ccacacgccc tggcctcggc aaccccggct tcgccgcgcc
    11221 gcgctcggcc accggcttcg acatcgaccg gtacgcgctg gcctgtctgc ggctggcgct
    11281 gttcctgccg atgaccaacc tgctgggcct gcaccgggtg aaggcgcggc acttcgccga
    11341 gatcatcgcc acgcacttcc cggtggagcc cgacttcctc gcccgcgccg tcgacgtgat
    11401 cgtgccgtcg aacaccccgt ccacgccgag cccgaagacg gaaccggact cggacggctg
    11461 gcccgcactg cggaacgagc tggccgacgc gatcgtcgcc agcgcgacac cgttacgcga
    11521 ggaccggctg ttccccggcg acccccaaca gttcgcggtc ggcgggctcg ggctcgccta
    11581 cggcgcggcc ggtgtgctgc acgcgctgtc ggtcaccggt gcgggccgct acccggagct
    11641 ggaggactgg ctggtgcgtc acgcgacgaa cccgccgacc ggcagccggc tgggtctcta
    11701 cgacggcctg cacggcgtcg cgttcgccct ggaacacctc ggccgccgcc aggaggcgct
    11761 ggacgtggtg gacatctgcc tccgggagaa ctggacgacg ctcggctcgg atctggtcgg
    11821 cggcctgccc ggcatggggc tgaacctgct gcacctggcc gatcgcaccg gagagccggc
    11881 gctgcgcgag gccgcgcacc gggcggcgga gcgggtggcc gaccggctga gccctgacat
    11941 gccggacgac gtaccggact acgagttcca gtcggacagt tccgcggaga tcagcggtgg
    12001 cgggagtcca ctcgcggggc tgctgcgcgg gcgggccggc tcggcgctgt tgctgctgcg
    12061 cctctacgac gacaccggcg acaccgccta cctcgagcgg gcccgggtgg ccctgcggca
    12121 ggacctgcgc tgctgtgtgc tgcgggacaa cggcgtgctc gaggtgaacg agggctggcg
    12181 gaccatgccg tacctcgacg gcggcagtat cgggatcggg atggtgctcg acgagtacct
    12241 tcgccggtgc ccggacgaac acttcgcgct ggcgaaccgc ggcgtcgaga tggccgcgcg
    12301 ctcgaccatg tacatcctgc cgggcctgtt caccggacgc gccggcgtcg tgctctacct
    12361 ggccggccgt tcgccgtcac cggtgaccga tccgctggtg gccaagcagg tgcgcgcgct
    12421 cgcgtggcac gcgttgccct acggcggcgg catggcgttc ccgggcaccg cgctgctgcg
    12481 gctgtcgatg gacctcgcca ccggcaccgc cggcgtactg ctcgccatgg gcgccgccct
    12541 gcacgaccag ccggtgcggg cgcccttgct caccctcgcg cgggatcccg cgcccaagac
    12601 gcccacggcg accgtcgtgg gtttggaaag acagttctag ggagcgacga tggcacttct
    12661 cgacctgcag ggcatggatg ctgcaccgca gcacggtcac ggtggcggaa gcagcgccag
    12721 cggccacagc tgcccgagca acctgagcgt gacgctgtgt ggcggcacca gcggcctgag
    12781 cctgctgatc tgccactgat acccgcgata ggcgggacgc ggtcccggac gatctgtagt
    12841 cgtccggggc cgcaccccta atgaggagcg taaatcgtgt ccaccttccg cgcgacggct
    12901 cgacgggcag gttcctggct cccgttgctc ggtttgtccg cgttggccgg aacgttgagc
    12961 ctgctggccc tgccggtggt gctcggcaac acggtcgacg cgatcgtgtc caatgcggac
    13021 agtcttcgct ggctggcgct ggccgcggcg ctgatcggcg tcggcgtcgc ggccgacctg
    13081 atcgacgcgt acgcgggtgc ggcgtgtgtc gccggcacga cggcgtggct gcgtgaccgg
    13141 ctggtcggcc atgtgctggc ggtcggcccg cacggtggcc gccggctcga caccggcgac
    13201 ctggtgagcc gggtgtccgg caacgcggcc gaggcggcac aggccgggcc gagcgtggtg
    13261 gccgtcgtcg ccgcggtgct gccaccggtg ggcagtttgg tgctgctcgc cctcatcgat
    13321 ctgtggctcg cggtcgcctt cctggccggg ctcgtactcg tcgccgtgat cctgcgggtg
    13381 ttcacccggc aaaccgccga ggtcgtctcc gcttatctgc gtgcccaggg gcgcatcgcc
    13441 ggccggctgt ccgagtcgct ggccggtgtc cgcacgatcg ccgccgccgg caccgtcgag
    13501 ctggaggagc ggcgggtgct ggagcacctg cccgagttgc accggcaggg cgtgcggagc
    13561 tggcgggtgt tgtcccggtc gagcgcgcag gccgccgtgg tggggccgct ggtgctggtc
    13621 gccgtgctgg ccaccggcgg tgtcgcgctc agtgccggcc ggatcagtcc gggggagttg
    13681 ttcgcggcga gtcagtacgc ggtgatcggt gccgggctcg gcggtctcac cggcatgttc
    13741 ggcaggctgg ccaggtccaa ggcgggtgcc gccagggtcg gcgaggtgct ggatctcgac
    13801 ccggtgcggc acggcggccg gaccctcccg gagggcaccg gccggctgga gtttcggggc
    13861 gtgacggttc gcgccggcga cgttccgctg ctggacggtg tcgatctcgt ggtgcccggc
    13921 ggctcgacgg tcgccgtggt cgggccatcc ggcgccggga agtccgtgct gacggcggtc
    13981 gccgcccggc tgtgcgaccc ggacgaggga accgtgctgc tggacggggt gccgctggac
    14041 gagctgtgtc acgaggcgct gcgcaccgcc gtcggctgcg cgttcgaccg gccggtgctg
    14101 gtcggcgcga ccgtggcgga cgcgatcggg tcgcggtggt cgcccgagca ggtcgaggcc
    14161 gccgcccgcg ccacgtactc gcacgacttc gtcagccggc tgccgcaccg ctacgcgacc
    14221 ccgctgaccg acgcgccgat gtccggcggc gagctgcagc ggctggggct cgcccgggcc
    14281 tggcgggccg agcggctgct ggtgctcgac gacgccacgt ccagcctgga caccgtgacc
    14341 gagatgcgca tcggccagac cctgatcgga gacggcgggc gcacccggct ggtcgtgacc
    14401 caccgggcgt ccaccgcggc gcgggccgat ctcgtggtgt ggctggcggg cgggcgggtg
    14461 cgcgcggtcg gtacccacga acagttgcgt gacgagccgg actaccggga ggtcttcgga
    14521 tgaggcggga gctgcgggtc gcggccaggt cgctgcggcg gcgcccactg ctcgcgctgg
    14581 tggccgcgtc ggttcccgag gcgttgccgg ccgcggtgtc cgggctggtc gtggcccgcg
    14641 cggtcgatca gggtttcctc gccggagcgc cgggcaccgg gctggcctgg ctcggcgtgc
    14701 tgctggtcac cgccgcggtc ggcgcggtcg gcactcgggc ggtgttccac cggctcggcg
    14761 atctcaccga accgttccgg gacgacctgg tgcgccgggt ggtgggcggc gcgctgcgca
    14821 acggtgtcgc cgggcgggcc gaccagggtg cgctggccag gctgacccgc caggtcgaga
    14881 tcgtgcggga cacctatgcc ggactgctgg tcgcggtgcg cgggttcgtg gtcaccgcga
    14941 tcggcgtgct cgtcggcctg ctgtcgatcg ctccttcggt cgctttgctg atcctgccgc
    15001 cgttcctgct cggcctggtc gcgttcctgg ccacgctggg gttcgccgcc aaccgccagc
    15061 gcgcgtcggt actcgcggac gaacggctgg ccgacgtcgc ccaggcggtg ctgcgcggca
    15121 cccgcgacgt cgtcgccacc ggccgcgaac ggcacgcctc ggggatggtg gccgaggcgg
    15181 tcgccgagca ggccgccgcc gaacgcgcgc tcgccggcgt cgcggcgttg cgcaccgcgt
    15241 gtttcgtgat cggcggctgg ggcccgctgc tggtcctgct gttcgccggt ccgtggctgg
    15301 ccggtcaggg gctcaccgcg ggcgcgatcc tgggcggctt gacgtatgtc ctgttcggac
    15361 tccagccggc actgcagaac ttcgtcggcg tcgtgggcgg cagcgggctg cggttcgtgg
    15421 tgaccctcgg ccggctgctc gacgcgagcg caccgccgcc cgacacgcgc gccggtcacg
    15481 gtgtcccggc cggccacgac gtggaactgc gcggcgtgac cttcgcctac ggcccgcacg
    15541 ccgagccggt ggtccacgac ctgagcctga ccgtgtcgcc gggggagcac ctcgcggtcg
    15601 tgggcccgag cggcatcggc aagtccaccc tggccgcgct gatgtgcggg ctggtccgcc
    15661 cggatgaggg gaccgtgcgg cacggcggcc tcccggccga cgcggtctcg ccggcggcgc
    15721 gcgtgctgat cccgcaggag gcgtacgtgt tcgccggcac ctgctgggcg aacctgacct
    15781 acctgtcgcc cgacgcgacc accggccagg tcgacgacgc ggtcgaggcg ctcggcgcga
    15841 cggcgctgct gaccaggctc ggcggctact cggcgaacgt gcggccggcc gagctgtccg
    15901 cgggcgaacg gcaactgttc gcgctggtgc gcgcctacct ggccgcggcg ccgctggtgg
    15961 tgctggacga ggccacctgc cacctcgacc cgatcgccga gcggaccgtg gaggaggcgt
    16021 tcgcccgccg gggcggcacg ctggtggtca tcgcgcaccg ggtcagctcg gcgctgcggg
    16081 ccgaccggat cctggtactc gacgggaccg aggggacggt cggcgaccac acgacgctgg
    16141 tggcgtcctc ggcgctgtac cgggatctcg tgggccactg ggtggcgggc cggccgcagg
    16201 acatcgtggt gtcctagcta cccgtgttac agccagccgg cgtcggtcgc gatctggatc
    16261 gcctggatcc tggtccggcc gccggtcttg cacatcgcct tggacaggta gttgcgcacc
    16321 gtccccggcg acaacgccag gctcttggcg atctccggtc cgctcgcgcc gtccgcggcc
    16381 aactggagcg tctgccgctc ccggggcgtg agcgggttgc gggtcgccga cagcgcggcc
    16441 accaccagat tcgtgtcgat catcgattcg ccgtcggcga ccttgcggat ggcctgcagc
    16501 agccgcacgg gcggcgcgtc cttgtcgatc agcccaccga cctccagctc gatcaggtgg
    16561 ctgaccaggt ccggcggctt ggtcacgatc agcgccacga tcccgcactc cggcacctcg
    16621 tcgcgcagcc cgcgaacggt ggacaggcac tgcggatgcg gcaggtcggc cagcaccgcg
    16681 acgtccggcc gcagccgcct cgccacgggc atcaccgtgt cgaggtgctt gacgtcggcg
    16741 acgacctcga tgtcgtcctc gtcggacagc aggctgacca gcgcggcccg cagcaggtcc
    16801 atccgctcga ggatgacgat cctgatcggt ctcgattcgg tatggaaacg gtcctgcacg
    16861 gttgccaccc ccactggtcg agccacggga ccttctcctc tcgtgagcga taccgatact
    16921 ccacgtctag tttcccaata gggcggcgga gcgttacgtc cgtgcgtgcc taccacgacc
    16981 attcctcgat tccgtcgtga cctgccagag ttgtctttct cccgggctcg ccgccgctca
    17041 agcccttcgc gcacaacggg tacgtggtcc tgggctgtga cctgaatgtg tcctcatact
    17101 ttcgctgatt cgccggtttc gccgattcca atatatgtgc caccgccgat gaccaccgtt
    17161 tatggcacct tccgctaaac ggtttaggaa aaccgcttgt gctaccgact ggtaactcac
    17221 cctcgcgtca ggcaagctct tggacatggc gtggatggtg tatggggcga acgggtacac
    17281 gggcaagctg gtcgcggagc tggcggtgaa gcgcggcgag ctgccggtcc tggcggggcg
    17341 cacggccgcg aaggtggctc cgctggccga cgagctgggg ctggagtacc ggatcttcga
    17401 tctgggcgac ccgaccgcgg tgcgcgacgg gctggacggg atgacgaccg tggcgcactg
    17461 cgccggcccg ttctccgcga cggcggcgcc gatggtggac ggctgcctgg ccgccggcac
    17521 ccactacgtg gacatcaccg gcgaggtcga cgtgttcgag gcgatcttcg ccaggaacgc
    17581 cgacgccgag cgggccggcg tggtgctgct gccgggtgcc ggcttcgacg tggtgccgag
    17641 cgactgtctc gccgcgatgc tggccggcga gttgcccgac gcgaccgagc tggacctggc
    17701 gttcgtggcc ggcggcggga tcagccccgg caccctgcgc accaccgtcg agggcatggg
    17761 caccggcggt cgcgcgcggg tcgacggcaa gctcgtcacc gtgccggtcg cgcaccgcag
    17821 cacggtcgcc gagctgccgt ccggcccgaa gaccgtggtg tcgatcccgt ggggcgacct
    17881 ggccaccgcg taccggtcca ccggcatccc gaacatcacg acgttcacca gggtgcccgc
    17941 cccgcccaag gccatcgcgg ccggtcagcg gctcttcggc ccgatcatgc gctcgtcggc
    18001 cggccagcgg gtcgcgaaga acctggtcgg ccggataccc ggcccgagcg agaagcgcag
    18061 ggcgggcagc cgcaccgagc tgtggggtcg ggtacgtgac gcgaacggcc ggtcggtgtc
    18121 caggacgctg gtcgtgccga acacctacac gttcaccgcg gacgccgtgg tgcgtgtcgt
    18181 cgagcggctc ggcaagggcg ggaccccggc cggcgcgcac acgccgtcca gcgcgttcgg
    18241 cgcggacttc gtgcgcgggc tggacggcgt gacggtcggc tgaccggcta cggggtcggc
    18301 ttcaacttcg ggtcggattc ctcgccggcg gcggtggccg cgaccacggc gccgccaccg
    18361 gtggggacgt cggccgcgtc cccggtgggc gtctggtcgt tctcctcggc ggccttggcc
    18421 ttcttccgct tgcgcaggat gaacaggata accagcaccg cgatcacgcc gaggatgatc
    18481 caactggcgt tgccgaccgc cttctccacc tgctcggcgg cctcaccggc ggcggcgccg
    18541 ataccgatgt gcagggcgca ccacgccgtc gcgccgaccg ccacggcggg gaagaacttg
    18601 cggaacggca gcccggacgc acccgccgcc gcgggcacga gcgttcgcat caccggtagg
    18661 aagatcgcga tcagcacggc ccacgagccg cgcctgcgca gtacgtcggt ggccttgtcc
    18721 cagccgttcg cgccgtgttt ctccacgagc ttggacttgc ggatcttggg cccgaagaac
    18781 ttgccgatga agaacccgac ggactggccg gcgatcgcgc agatcgacgt gaccagccac
    18841 atgatcagga acttcggcgt gctgtccacg gtggtgccga ggatgaacag gccggtctca
    18901 cctggcgcga tgaaccccaa cccgagcgtg cactcgccga acacgagcac acccgcggcc
    18961 gcggtcaccc ccgccggcgg gagctccctg agccagttca acacatcggc aaccacggac
    19021 accgtctgat cctccccgtt gtcgccgcac gcggcggcgg accgtcaagc catcggtcgt
    19081 tggaggaagc gtcgcacgtt gcggttcccg cccggatccc cctacggcct gatttcgcgg
    19141 tcagactagc ggctgaggat cgagccgatc tcctggcgtg ccggtcccga ctcgacgagg
    19201 tgccgcaggt tctccggcac ctcctcgccg cggtgggcct tcgcctgcgc gtacagccgc
    19261 ccggcccggt acgacgagcg caccagcggc ccggccatca cgccggcgaa gccgatcttc
    19321 tcggcggact ccttgtgccg cacgaactcc tccggcttca cccagcggtc gatcgggtgg
    19381 tgccgcaggc tcgggcgcag gtactgggtg atcgtgatga tgtcggtgcc ggcgtcgtgc
    19441 aggtcctgca gcgcctcggt gacctcgtcg ggcgtctcgc ccatgccgag gatcaggttg
    19501 gacttggtga ccagaccgaa ctcgcgggcg cgcgtgatca cgtccagcga gcgctcgtac
    19561 cggaatcccg gccggatccg cttgaagatc cgcggcacgg tctccaggtt gtgcgcgagc
    19621 acctccggcc gcgagccgaa cacctcggcg agctggtcgg ggtcggcgtt gaagtccggg
    19681 atcagcaact cgacgccggt gcccgggttc agctcgtgga tctggcggac ggtctcggcg
    19741 tacagccacg cgccgccgtc ggccaggtcg tcccgggcca caccggtgac cgtggagtac
    19801 cgcaggccca tcgcctggac cgactcggcg accttgcgcg gctcggtgcg gtccagcgcc
    19861 gccggcttgc cggtgtcgat ctggcagaag tcgcaccggc gggtgcactg gtcaccgccg
    19921 atgaggaacg tcgcctcgcg gtcttcccaa cattcgaaga tgttcggaca gcccgcctcc
    19981 tcgcacaccg tgtgcaggcc ttcgcgtttg accaggctct tcagttcggt gtactcgggc
    20041 cccatcttgg cccgggtctt gatccacgag ggctttcgct cgatgggcgt ctcgctgttg
    20101 cggacctcga gccgcagcaa cttccgcccc tccggggtca ccgtcacgcc tgtcacgtta
    20161 cgcccagggc ctgagtgtcc gggctcacac gtcacgccgg gtcgggggtg atcccggtga
    20221 gttcggcggt gcggtcccag agcgtgccgg ccagctcggt gctggtggcc gcgcggcgcg
    20281 ccttgacgtg gccgggcgtg ccgaagaact ctccaggccc ggtcggcccg atgaagtcgc
    20341 caccccgcac gtcggccacg gtggcggcat agagctgggg gagcgcgccg cgcttgaccg
    20401 actggctgac cactttgtag ccgaagtcga aagccatggt cagcacgttg ttgaccatgc
    20461 cggtgccgcg cgagcgcatc gagttggcgg ccagctcggt gtcggtgaca ccggggtgcg
    20521 cggcgatgct ggccaggtcg agctcagcgg cacgggcccg ccggtccagc tcgaaggcga
    20581 acagcaggtt ggccatcttg ctctggctgt acgcgctgcc ggacgtgtag cggcggcgct
    20641 cgaagttcag gtcgtccacg tccaagccgc cgccgcggtg cgcgacgctg gacagtgtca
    20701 ccacccgcgc gccaggagtg gcacgcagcg cgggcgcgag cagccaggtg agtgccgcgt
    20761 gcccgaggtg gttggtgccc agctgcagct cgaacccgtc cgcggtcttg cggttcgggg
    20821 tggccatcac gccggcgttg ttcatcagca cgtgcagcgt gtcgccggtc ttgtcgcgca
    20881 cctcggcggc ggccgcgcgc acggacgaca ggtcggcgag gtcgagctgg atcagctcgg
    20941 cctcgccgcc gatgtcacgt acctggtgca cggcgtcctc gccgcgctcg ggcgaccggc
    21001 aggcgagcag caccttcgcg cccttgccgg ccagcacgat cgcgctgcgc aggccgagcc
    21061 cggagttggc cccggtgatc aggacggtct tgccggtctg gtccgggatg tcggcctcgc
    21121 tccagcgcgt cataccgaag atcgtagagc cgatcaggcg ctgggcacga gccgacgcag
    21181 cagttgctcg accgggtttc gacgtcgggc gggccgctgc ggcacgctgt gcagcaacgc
    21241 gttgaacgcc acgccgaccc gggtgatctc ctcgtctggc tcggtgatct cggcgagtcc
    21301 cgcggtcagc gcgagcatcc gctgctcggc gcgcaccgcc cggccgaacg tgccgccgac
    21361 gcggtcggag ttcgtgtcca ggatcgcccg cagtgccgag ttctcgtccg cggccttgtg
    21421 ccacgcctcg gtcaccgctt cgacccggtc gatcgacgag tcgcggtcgg cctcggccag
    21481 cgccatgtcg acacgcgcgg tgagcttcaa cgtccaccgg tagtgcagcg cggcgagcag
    21541 ctcgtccggc ccactgaaga tctcggaaac ccctggtacc tcgtcgaacg gcagcccacc
    21601 acccgggttg cgggtggcgt gctgaatgac ggcgtcgagc gcgtcgcgcc gtcggtagta
    21661 gtcgttccag ctcatggctt gcctcccctc cgcagttctg gtgataccgc cggtttgcgg
    21721 cataccgtcg gtacggtccg acaaggccaa cgtaccatcg gtacgtaccg gcggtatgtc
    21781 gtacggttgt gagcgtggtg acattgcggt cgcggcgagc ggactactcc gagtccacca
    21841 gacaggcatt ggtggactcg gcggtagagc tgttcaccaa gcgcggctac gcggccacgt
    21901 cgctggatgc cgtgaccaag cgcgcgcggg tcaccaaggg cgcgctgtac caccacttca
    21961 gcggcaagca ggcgctgttc gaggccgcgt tcagcgcggt ggagacggcg gtgttgaagc
    22021 gcctcggcga ggtcgccgtc gccgggcccg gctcgccgtg ggaccgggcg atgcgcggtg
    22081 tcgaggccta cgtgcaggcc tgcctcgaac ccgcgtacca gcgaatcgtg atccacgagg
    22141 gcccggtcgt gatgggctgg gagcgctggc gcgaggcgga ggaccatttc agctacggcc
    22201 tcatccggac ggtgatccag agtctgatcg aggcgaagga gatcgtcgag ctaccggtcg
    22261 aggtcaccgc gcggatgctg ttcggcgcgc tgtcctcggg cgctaccttc ctggccaacg
    22321 ccacggaccc gaagaaggcc agtgcggaag tgtccaacgc gatcacccag gtgctcaccg
    22381 gtctgcggat caagaaggac gactaggtcc gcaccgcgaa cgtgacgccg gggctctccg
    22441 gctcggcccg cgacacccac cggtcggtga tcggcaggtc gccctccagc gccgcgagta
    22501 cggcgtcgcg ggccagcggc agcacctcgg ccaccggcac gtcccgcccc agttcctcgg
    22561 acagcgaggt gacaccggcg tcggcgatcc cgcacggcac gatccggtcg aacgcgctca
    22621 ggtcggcgtc gcagttgatc
//
