LOCUS       NZ_SGWQ01000001        10435 bp    DNA     linear   CON 10-APR-2024
DEFINITION  Herbihabitans rhizosphaerae strain DSM 101727 Ga0310478_101, whole
            genome shotgun sequence.
ACCESSION   NZ_SGWQ01000001
VERSION     NZ_SGWQ01000001.1
KEYWORDS    WGS; RefSeq.
SOURCE      Herbihabitans rhizosphaerae
  ORGANISM  Herbihabitans rhizosphaerae
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Herbihabitans.
REFERENCE   1  (bases 1 to 1096878)
  AUTHORS   Goeker,M.
  TITLE     Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing
            the most valuable type-strain genomes for metagenomic binning,
            comparative biology and taxonomic classification
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1096878)
  AUTHORS   Goeker,M., Huntemann,M., Clum,A., Pillay,M., Palaniappan,K.,
            Varghese,N., Mikhailova,N., Stamatis,D., Reddy,T., Daum,C.,
            Shapiro,N., Ivanova,N., Kyrpides,N. and Woyke,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (14-FEB-2019) Prokaryotic Super Group, DOE Joint Genome
            Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.12.0
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 226.0x
            Sequencing Technology             :: Illumina
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004216555.1-RS_2024_04_10
            Annotation Date                   :: 04/10/2024 19:27:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,690
            CDSs (total)                      :: 6,628
            Genes (coding)                    :: 6,561
            CDSs (with protein)               :: 6,561
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 2 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 67
            CDSs (without protein)            :: 67
            Pseudo Genes (ambiguous residues) :: 0 of 67
            Pseudo Genes (frameshifted)       :: 13 of 67
            Pseudo Genes (incomplete)         :: 59 of 67
            Pseudo Genes (internal stop)      :: 5 of 67
            Pseudo Genes (multiple problems)  :: 9 of 67
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:31:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 665964
            Orig. end                         :: 676399
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            SGWQ01000001.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10435
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="3"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10435
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10435
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5435](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5435)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    41..56
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    450..464
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 21.95"
                     /tool="antismash"
     gene            complement(911..3715)
                     /locus_tag="EV193_RS03425"
                     /old_locus_tag="EV193_101688"
     CDS             complement(911..3715)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="EV193_RS03425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101688"
                     /product="AfsR/SARP family transcriptional regulator"
                     /protein_id="WP_130342443.1"
                     /transl_table=11
                     /translation="MPGDGEQEAGLQFCLLGPIQVLRDGRQVPMGDRGSRAVLAMLLLE
                     ANRTVAIDRIVDVLWAHEPPATARTMVQGYVSRLRQRLTAHDPEDGGARIVTRRPGYQL
                     VVDEARIDRHRAQRLLADARREPAARRAEMLRHALRLWRGEALADVADRVRAPELVELK
                     VAVLEARVDADLELGRHAELVGELSEHLEDHPFAERLAGQLVLALYRCGRRASALETYQ
                     RFARRMADERGIDPGPELRDLQARVLADDVTLLPETLGAQRVGPLVPAQLPTTPPGFNG
                     RDAELAWLDDVLSTMDSSTVAIAVLAGPAGVGKTSLALRWGRGVVAEFPEGQLYVSLRG
                     FDPQHPPVDPAEVLTQFLLSLGVAADEVPVALDDRAALYRSLLADRRVLVVLDDARDSA
                     QVRPLLPAGSRSLVLVTSRVRLDGLVADGGRLLLLGTLPPDAALRIIEETARFADGVAD
                     LEQRRRLVELCGRLPLALRIVGARLAASPQWSVDELIEELTDERTRLGALDVEGAHTSV
                     RAALDVTYRALHPAMAGTYRMLGLFPGRVISPLPVAALCSIDAANARRRLRALAAVFLV
                     TEESPDTFVMHDLVRLHAGGLATAELGTDVRDAALIRLAHYYLVAGDHARRLLRPVFDG
                     LTPAEDYPQLVPPDMPEADDALDWFEREWSNIFAVLRVTRQHGRHTEVWKIARVAQDFR
                     AVRSRLDDWLSLVQLGLESARAAGDPVGEVWMLVSRCSAYSRFAMSDQTLTDAERALAI
                     AIDLRDPLLMAIGYNTVASALYGQGRTEDAMLRYREALVLVRTTDNKAIEANLLNNIAQ
                     MEQALGRPAEAIGPQRAALELYRQTREHGFELFALVNLAELYLETGGVDEAETHARQGV
                     LEATQSGLALQEAFARQVLGQVLSFRQDLNGAREQWLRSLELYTELKQPRAAAVRAELD
                     ALGT"
     gene            complement(4099..5004)
                     /gene="thpD"
                     /locus_tag="EV193_RS03430"
                     /old_locus_tag="EV193_101689"
     CDS             complement(4099..5004)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005441527.1"
                     /locus_tag="EV193_RS03430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101689"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_130342444.1"
                     /sec_met_domain="PhyH (E-value: 2.7e-35, bitscore: 118.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVIDTKTEDRYPTRTSYGLELIERTDPTVWSNGCHDGPIDPATL
                     ASHDTKGYSIYEGLLSPAEVQAYWQELERLTNDESLKADERVIVEKSSNQVRSVFEVHK
                     ISELIAELVSDPRVLDRARQILGSEVYVHQSRVNYMPGFKGKGFYWHSDFETWHAEDGM
                     PAPRAVSASIALTDNYPFNGGLMVMPGSQRTFVPCQGETPEDHYKASLKEQEFGVPNED
                     DITKLVAEHGIDQFTGPAGSTLFFDSNIMHGSGNNITPFPRSNIFVVFNSVENTLVEPF
                     AAPTARPTFIGARDFTPVTR"
     gene            complement(5001..5435)
                     /locus_tag="EV193_RS03435"
                     /old_locus_tag="EV193_101690"
     CDS             complement(5001..5435)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007025600.1"
                     /locus_tag="EV193_RS03435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101690"
                     /product="ectoine synthase"
                     /protein_id="WP_130342445.1"
                     /sec_met_domain="ectoine_synt (E-value: 4e-53, bitscore:
                     174.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSMSDIQPGHERYTQSENWHSRRIVLAQEGVGFSLHETVLYA
                     GTVNDMWYANHVEAVYCIGGKGDLLDKETGESYRIEPGTMYLLDGHEKHRLSCETEMTM
                     VCVFNPPVTGQEVHDEHGVYPLIIPNDVPTTTEGAKEASA"
     gene            complement(5464..6711)
                     /gene="ectB"
                     /locus_tag="EV193_RS03440"
                     /old_locus_tag="EV193_101691"
     CDS             complement(5464..6711)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (21-354). E-value: 8.7e-70.
                     Score: 227.3. Matches aSDomain:
                     nrpspksdomains_EV193_RS03440_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015787752.1"
                     /locus_tag="EV193_RS03440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101691"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_130342446.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.5e-73, bitscore:
                     243.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVFETLESEVRSYCRSWPTVFDKAVGSYLYGEDGRPYLDFFAGA
                     GALNYGHNNPILKTALIDYIQRDGVTHGLDQQTVAKRDFLETFQELVLKPRELDYKIMF
                     PGPAGANAVEAALKLARKRTGRESIINFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHA
                     TPMPYDNYFDGATPDFLFFERLLNDSGSGLNEPAAVIVETVQGEGGINAARLEWLQGLS
                     ELCERHDILLIVDDVQMGCGRTGPFFSFEAAGIKPDIVCLSKSIGGYGLPMALTLFKPE
                     LDIWEPGEHNGTFRGINPAFVTSTEALRTYWADDKLEKSTLAKGEQVGRVLGELAEANT
                     SVSMESKGRGLARGLGFETGEQASAVCKAAFERGLLMETSGPDGQVAKIMPPLTVTDDE
                     LAKGLDIVADSVRAAV"
     aSDomain        complement(5650..6648)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EV193_RS03440_Aminotran_3.1"
                     /evalue="8.70E-70"
                     /label="EV193_RS03440_Aminotran_3.1"
                     /locus_tag="EV193_RS03440"
                     /protein_end="354"
                     /protein_start="21"
                     /score="227.3"
                     /tool="antismash"
                     /translation="FDKAVGSYLYGEDGRPYLDFFAGAGALNYGHNNPILKTALIDYIQ
                     RDGVTHGLDQQTVAKRDFLETFQELVLKPRELDYKIMFPGPAGANAVEAALKLARKRTG
                     RESIINFTNAFHGMTLGALSVTGNSMKRGGAGIPLVHATPMPYDNYFDGATPDFLFFER
                     LLNDSGSGLNEPAAVIVETVQGEGGINAARLEWLQGLSELCERHDILLIVDDVQMGCGR
                     TGPFFSFEAAGIKPDIVCLSKSIGGYGLPMALTLFKPELDIWEPGEHNGTFRGINPAFV
                     TSTEALRTYWADDKLEKSTLAKGEQVGRVLGELAEANTSVSMESKGRGLARG"
     misc_feature    6772..6786
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            complement(6786..7337)
                     /gene="ectA"
                     /locus_tag="EV193_RS03445"
                     /old_locus_tag="EV193_101692"
     CDS             complement(6786..7337)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466527.1"
                     /locus_tag="EV193_RS03445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101692"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_207222470.1"
                     /transl_table=11
                     /translation="MSGKHTSRAGGENQVTGETLIEQPSKMDGAAIWRIARDSGKLDLN
                     SSYAYLLWCHDFADSSVVARVDGDVVGFIIGYVKPRSPDTVVVWQVAVDASQRGKGLAG
                     KLLDQLLRQLADQGVRHMETTITPDNTASQRLFGSLAERWGATLERTELFDSAQFPDEH
                     ESEDLYRIGPFVRAPEQVSA"
     misc_feature    7380..7396
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 17.23"
                     /tool="antismash"
     misc_feature    complement(7411..7424)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.43"
                     /tool="antismash"
     misc_feature    complement(7502..7515)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 18.17"
                     /tool="antismash"
     misc_feature    complement(7503..7516)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 17.29"
                     /tool="antismash"
     gene            complement(7573..8364)
                     /locus_tag="EV193_RS03450"
                     /old_locus_tag="EV193_101693"
     CDS             complement(7573..8364)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025695.4"
                     /locus_tag="EV193_RS03450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101693"
                     /product="Abi-alpha family protein"
                     /protein_id="WP_130342447.1"
                     /transl_table=11
                     /translation="MEERRSRPDVDGLITGAGRAAGWLAKAGWNVTKKLPGGDIADRQL
                     KRLEYAVVDEVRKRLDYPGNALASPERTAGWRRQAIEGEVTDSGNGSPAQLVEPLRAAM
                     AELLSASVTYGREASRDYLFAAVLRQVVPDEARILAATADGTVYPLVHLVTRGPLGGTR
                     RTLLENFSSVAREAGVALVDQGPVYVGRLVRFGLLDIGGENTAQAGYYDMLLADSRIRG
                     IIDGGKRVQVQRRTLGISAFGAELWEACDPSKLGQPELDRP"
     gene            8389..9651
                     /locus_tag="EV193_RS03455"
                     /old_locus_tag="EV193_101694"
     CDS             8389..9651
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018333370.1"
                     /locus_tag="EV193_RS03455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101694"
                     /product="RNA polymerase sigma factor"
                     /protein_id="WP_130342448.1"
                     /transl_table=11
                     /translation="MSQNLDAVTSAASAAFRDEWGQIVATLIRITGDWDLAEECAQEAF
                     AQALTAWARDGVPRKPGAWLTTAARNRATDRLRREAVGAAKLRELAAMTPVAQPDGTAY
                     DRDDDSGVSDDRLRLIFTCCHPALPFESRVALTLRTLAGLTTAEIARAFLVVEQAMQQR
                     IVRAKRKIRNAKIPYRVPPAHLLPERTSAVLGVLYLLFNEGYTATAGADLVRHGLIAEA
                     VRLARMLARLMPEETEARGLLALMLLHDARRATRLGPDGELVLLEDQDRTRWDAEEIAE
                     GVALLERTLAAGRPGPYQVQAAIAACHATARTAAETDWVQIAALYGQLARFVPSAVVEL
                     NRAVAVGMADGPAAGLVLVDSLRDKGDLDGYHLLPATRADFLRRLGRDDEAAAEYRAAL
                     ELAGTDAERRFLTSRLAEVTR"
     misc_feature    complement(8427..8436)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(9655..9670)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.94"
                     /tool="antismash"
     gene            9685..10020
                     /locus_tag="EV193_RS03460"
                     /old_locus_tag="EV193_101695"
     CDS             9685..10020
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020643658.1"
                     /locus_tag="EV193_RS03460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EV193_101695"
                     /product="metalloregulator ArsR/SmtB family transcription
                     factor"
                     /protein_id="WP_130342449.1"
                     /transl_table=11
                     /translation="MTDDDKVLDDAVFKALADPTRRFLLDLLFARDGRTLTELESELEM
                     SRFGVMKHLRVLEEADLVVTRKSGREKFHYINPIPIRLIHDRWIDKYTERRASALADLK
                     RQLEQEQ"
ORIGIN
        1 gcgaccagtc ggggtaggtc agctcgcccg tcgaaacggg ataggactcg accagctcga
       61 cccactccgt cgcgctggtg atctcacgga ccaccacccc gggtcgcggc acgaccgacc
      121 acacgtgcca cggccgagga tgcagcgtgg aatctcgatt gaggtcgaga tagatccgcc
      181 acatgccctg agtcccgagc acgcctgtcg acgtgaacag accgacgccg aacggcttcg
      241 tcgccggcac catctcggcc ggctccacga gcttttctcc atgaaggacg ggatctgttg
      301 gcgggagacc cgaaatcccg cccttcgcta tccagtactg cgagccgagt agcagatcct
      361 ccaccgcgat ctccggcacg gattcgcaca gcctgttcac gagccgcgac ttgccgatgg
      421 tgatgtccgc atcagcggcc gacaccggag gaattggcgt tccatcctcg gacatgctcg
      481 cgacattagt gatcttgtcc acgacatcga tgaagtacgt caaatccgta atcgccaagt
      541 cttcggcatg agcagttctc aggccgcacg aagactggga atcagcccca cttcgaagat
      601 ggctgctcac cgctgccgat gcgaacccgc cctggccgcc atcatccaat agcggaattc
      661 gctcggacag cttcgcccac gtcacggcca caacactagc agcccagcaa tagtttcgga
      721 ctcgttgccg atggcgcaaa ctggttgcca gagtagttct ccgtcctcga ttgccacagg
      781 ttcagcgaca gcggttccgg cgccaagaac cccaagcaat gccgcagctc cggtaatggc
      841 gagcacgctg ccccgttttc cgatattccc cacatcagtc tccccattga ctgtttcgtg
      901 gccaaattcc ctatgtcccg agagcgtcca actcggcacg gacagcagcg gctcggggct
      961 gcttcaactc ggtgtacagc tccagcgaac gcagccactg ctcgcgcgca ccgttcaggt
     1021 cctgccgaaa ggacagcacc tgcccgagca cttgccgcgc gaacgcttcc tgcagggcga
     1081 gcccggattg cgtcgcctcc agaactcctt ggcgcgcatg ggtttccgcc tcgtcgacgc
     1141 caccggtttc gaggtacaac tccgccaggt tgaccagcgc gaacagctcg aatccgtgct
     1201 cgcgcgtctg tcgatacagt tccagcgccg cccgctgcgg gccgatcgcc tcggccggcc
     1261 ggcccagcgc ctgttccatc tgcgcgatgt tgttcagcag gttcgcctcg atcgccttgt
     1321 tgtccgtcgt gcgcaccagg accagcgcct cgcgatatct gagcatcgcg tcctcggtcc
     1381 gcccctgccc gtacagcgcg ctggccaccg tgttgtagcc gatcgccatc aacagcggat
     1441 cccgtagatc gatcgcgatg gcgagtgcgc gctccgcgtc ggtcagcgtc tggtcggaca
     1501 tcgcgaaccg gctgtacgcc gaacaccggc tgaccagcat ccagacctcg ccgaccggat
     1561 cgccggcggc ccgcgccgac tccaggccga gctggacgag cgacagccag tcgtccagcc
     1621 gcgaccgcac cgcccggaag tcctgcgcca cccgcgcgat cttccacacc tcggtgtgcc
     1681 ggccgtgctg gcgcgtcacc cgcagcaccg cgaagatgtt cgaccactcg cgctcgaacc
     1741 agtccagcgc gtcgtctgcc tccggcatgt cgggcggcac cagttgcggg tagtcctcgg
     1801 ccggcgtgag cccgtcgaac accggccgca gcaggcgtcg cgcgtgatca ccggcgacca
     1861 ggtagtagtg cgccagccgg atcagcgcgg cgtcccgcac atcggtgccc aactccgcgg
     1921 tggcgagccc gccggcgtgc agccgcacca ggtcgtgcat cacgaacgtg tccggacttt
     1981 cctctgtcac aaggaaaacc gccgcgagcg cacgcagccg ccggcgcgcg ttggccgcgt
     2041 cgatcgagca cagcgcggcc accggcagcg ggctgatcac ccggccgggg aacagcccga
     2101 gcatccggta cgtgccggcc atcgccgggt gcagcgcgcg ataggtcacg tcgagcgctg
     2161 cccgcacgct ggtgtgcgcg ccctccacgt ccagcgcgcc gagccgggtg cgctcgtcgg
     2221 tcaactcctc gatcagctcg tcgaccgacc actgtggact cgccgccagc cgcgcgccca
     2281 cgatgcgcag cgccagcggc agccgcccgc acaactcgac cagccgccgc cgttgctcca
     2341 ggtccgccac accgtcggcg aaccgcgcgg tctcctcgat gatccgcagc gcggcgtccg
     2401 gcggcagcgt gccgagcagc aacagccgcc cgccgtcggc gaccagcccg tccagccgca
     2461 cccgggaggt gaccagcacc agcgaccgcg agccggccgg cagcagcggg cgcacctgcg
     2521 cggagtcgcg cgcgtcgtcg agcaccacga gtacccgccg gtcggccagc agcgaccggt
     2581 acagcgcggc ccggtcgtcc agcgcgaccg gcacctcgtc ggcggccaca cccaacgaga
     2641 gcagaaactg ggtgagaacc tcggccggat cgaccggcgg gtgctgcggg tcgaacccgc
     2701 gcaggctcac gtagagctgg ccttccggga actcggcgac caccccgcgg ccccagcgca
     2761 gcgcgagcga ggtcttgccg accccggccg gcccggccag tacggcgatc gccacggtcg
     2821 aggagtccat tgtggacagc acgtcgtcga gccaggccag ctccgcgtcg cgcccgttga
     2881 acccgggcgg agtggtcggc aactgggccg gcacgagcgg cccgacccgt tgtgcgccaa
     2941 gggtttccgg caacagtgtc acgtcgtcgg cgagcacccg ggcctgcaga tcacgcaact
     3001 ccggccccgg atcgataccg cgctcgtcgg ccatccttcg ggcgaaccgc tggtaggtct
     3061 ccaacgcgga cgcgcgccgg ccgcagcggt acagcgcgag cacgagttgc ccggcgagcc
     3121 gctcggcgaa cgggtgatcc tcgaggtgct cggacagctc accgaccagc tcagcgtgcc
     3181 ggcccagctc caggtcggcg tccacccgtg cctccagcac ggccactttc agctccacca
     3241 gctccggtgc gcgcacccgg tcggcgacat cggcgagtgc ctcaccgcgc cacagccgca
     3301 gcgcgtgccg cagcatctcg gcccgccgcg cggccggctc gcggcgcgcg tcggccagca
     3361 gccgctgcgc ccggtgccgg tcgatgcgcg cctcgtcgac gacgagttga tagcccggac
     3421 ggcgggtgac gattcgcgcg ccaccgtcct ccgggtcgtg cgcggtcagc cgctgccgca
     3481 gacgggagac atagccctgc accatggtgc gcgccgtcgc cggcggctcg tgtgcccaca
     3541 gcacgtcgac gatccgatcg atcgccaccg tgcggttggc ttcgagcagc agcatggcga
     3601 gaaccgccct gcttccccgg tcccccatcg gcacttgccg gccgtcccgc agcacctgga
     3661 ttggtccgag caggcagaac tgtagtcccg cttcctgctc tccgtcccca ggcatgtttc
     3721 acccccagct cccacgtccg tcgagccccc aggcccccac ctcgaagcgg atccctgaca
     3781 acgtagaggg aaaacgacgc gaaatacact cacgaggggc gcggaccaca gagagtcacg
     3841 cttatggagt agccgtcgag ggaggtcata cctccggacg ggcgaaggcc ccgcgccatc
     3901 cgttcccgat ccggacggtg cggggccttc gactccgaca agttgatcaa cagcgcatcg
     3961 ggcccacccc gagcgggggc cacgacgtgc tcttgatcaa tgattggcgg agccagattg
     4021 tggcggtact gcccagtacc gactcagcca atctaacagg ccgcatgcgg cccgttacaa
     4081 gagggtcatg ccaacttgtt accgagtcac cggcgtgaag tcacgcgcgc cgatgaaggt
     4141 cggcctggcg gtcggcgccg cgaacggctc gaccagcgtg ttctccacac tgttgaacac
     4201 cacgaagatg ttcgagcgcg ggaacggcgt gatgttgttg cccgacccgt gcatgatgtt
     4261 cgagtcgaag aacagcgtcg agccggccgg cccggtgaac tggtcgatgc cgtgctcggc
     4321 gacgagcttg gtgatgtcgt cctcgttcgg gacgccgaac tcctgctcct tgagtgacgc
     4381 cttgtagtgg tcctccggcg tttcgccctg gcacggaacg aaggtgcgct gcgaccccgg
     4441 catgaccatc agcccgccgt tgaacgggta gttgtcggtc aacgcgatcg acgcgctcac
     4501 cgcgcgcggc gccggcatgc cgtcctcggc gtgccaggtc tcgaagtccg agtgccagta
     4561 gaagcccttg cccttgaagc ccggcatgta gttgacccgg ctctggtgca cgtacacctc
     4621 ggaaccgagg atctggcgcg cgcggtcgag cacccgagga tcactgacca gctcggcgat
     4681 cagctcgctg atcttgtgca cctcgaagac cgaccggacc tggttggacg acttctcgac
     4741 gatcacccgc tcgtcggcct tgagcgactc gtcgttggtc agccgctcca gctcctgcca
     4801 gtaggcctgc acctcggccg ggctgagcag tccctcgtag atcgaatagc ccttggtgtc
     4861 gtgcgacgcc agtgtggccg gatcgatcgg gccatcgtgg cagccgttgc tccacaccgt
     4921 cggatcagta cgctcgatca actccagccc gtacgacgtc cttgtgggat aacgatcctc
     4981 ggtcttggtg tcgatcaccg tcatgcgctg gcctcctttg ctccctcggt ggtggtggga
     5041 acgtcgttcg ggatgatcag cgggtacacg ccgtgctcgt cgtgcacctc ctgaccggtg
     5101 accggcgggt tgaatacgca caccatggtc atctcggtct cacagctgag ccggtgcttc
     5161 tcgtggccgt cgagcaggta catggtgccc ggctcgatgc ggtacgactc gccggtttcc
     5221 ttgtccagca ggtcgccctt gccgccgatg cagtacaccg cctcgacgtg gttggcgtac
     5281 cacatgtcgt tcacggtccc ggcgtacaga accgtttcgt gcagggagaa gccgacgccc
     5341 tcctgggcga ggacgatccg cctgctgtgc cagttctccg actgcgtgta gcgctcgtgg
     5401 cccggctgga tgtcggacat ggaacggacg atcacgcgct tttcctcctc ggtttccggt
     5461 ggctcagaca gccgcgcgga ccgagtccgc gacgatgtcg agtcccttcg ccagttcgtc
     5521 atcggtgacc gtgagcggcg gcatgatctt ggcgacctgc ccgtccggcc ccgacgtctc
     5581 catcagcagg ccgcgctcga aggcggcctt gcacacggcg ctggcctgct cgccggtctc
     5641 gaagccgagc ccgcgcgcga ggcctcggcc cttggactcc atcgacacgc tcgtgttcgc
     5701 ctcggccagc tcgccgagca cccggccgac ctgctcgccc ttggccagcg tggacttctc
     5761 cagcttgtcg tcggcccagt aggtgcgcag cgcctcggtc gaggtgacga acgcggggtt
     5821 gatgccgcgg aaggtgccgt tgtgctcgcc cggctcccag atgtccagct cgggcttgaa
     5881 cagggtgagc gccatcggca ggccgtagcc gccgatcgac ttggacaggc acacgatgtc
     5941 cggtttgatg ccggccgcct cgaagctgaa gaacgggccg gtgcggccgc agcccatctg
     6001 cacgtcgtcg acgatcagca ggatgtcgtg gcgttcgcac agctcggaca ggccctgcag
     6061 ccactccagg cgcgcggcgt tgatgccgcc ctcgccctgc acggtctcca cgatcacggc
     6121 ggccggctcg ttcaggcccg agccgctgtc gttgagcagg cgctcgaaga acaggaagtc
     6181 gggcgtggcg ccgtcgaagt agttgtcgta gggcatcggc gtggcgtgca ccagcgggat
     6241 gccggcgccg ccgcgcttca tcgagttacc ggtcactgac agcgcgccca gcgtcatgcc
     6301 gtggaacgcg ttggtgaagt tgatgatcga ctcgcggccg gtgcgcttgc gagccagttt
     6361 cagcgcggcc tcgacggcgt tcgcgccggc cggaccgggg aacatgatct tgtagtcgag
     6421 ttcgcgcggc ttgagcacca actcctggaa agtctccagg aagtcacgct tggcgacggt
     6481 ctgctggtcg agtccgtggg tcacaccgtc acgctggatg tagtcgatca gggcggtctt
     6541 caagatcgga ttgttgtgtc cgtagttgag cgcgcccgcg ccggcgaaaa agtcgaggta
     6601 tggccgtccg tcctcgccgt acagataact gccgacggcc ttgtcgaaca cggtgggcca
     6661 gctacggcag tagctgcgca cctcggattc gagtgtttcg aagacgttca cgatactccg
     6721 tccgatcttg gaaagtctgg tctcgtcttt gagtcccgaa aggatccgct gatctcgcga
     6781 gtcgatcagg ccgacacctg ctcaggtgcc cgcacgaacg gtccgatgcg atacaagtcc
     6841 tcggattcgt gttcgtccgg gaactgtgcg gaatcgaaca actccgtgcg ctccagcgtg
     6901 gcgccccacc gctcggccag cgagccgaac agcctctggg acgccgtgtt gtccggcgtg
     6961 atggtcgttt ccatgtggcg aacaccctgg tcggcgagct gccgcagcag ctggtcgagc
     7021 agcttgcccg ccaggccctt gccacgctgc gacgcgtcga cggcgacctg ccacacgacc
     7081 accgtgtccg gcgatcgagg tttgacatag cctattatga agccgaccac atcaccgtcg
     7141 actcttgcga caaccgaact gtcggcgaaa tcgtgacacc acaacaagta ggcgtacgag
     7201 gagttcaggt cgagcttccc cgaatcgcgc gcgatccgcc agatcgctgc tccgtccatt
     7261 ttggacggtt gctcgatcag cgtctccccg gtcacctggt tttcaccgcc agcccggctc
     7321 gtgtgctttc cggacatacc aaagcaacgt aacagaagct tttcctgcgt tcagcccgac
     7381 tggaacaaga tcacacgggc tacctgggca ttcaaagaat tgtatgtgat aaagcccacg
     7441 aaagtattgc gatcaaggca attaatgtgc tatatagcgc ggccgccatt actcggcgtt
     7501 gttttttcgt caaaatccag cgctattcgc ccgtgtttcg tcgccggggg gtcgagtgtt
     7561 acaacccgcc ggtcagggcc ggtccaactc gggctgtccg agcttggacg ggtcacaggc
     7621 ctcccacagc tccgctccga acgcggagat gccgagcgtc ctccgctgta cctgtacccg
     7681 cttgccaccg tcgataatcc cccgaattcg actgtcggcg agcaacatgt cgtagtagcc
     7741 ggcctgcgcg gtgttctcgc cgccgatgtc cagcagcccg aaccgcacca acctgcccac
     7801 gtagaccggc ccctggtcga ccagggcgac cccggcctcg cgggccacgc tggagaagtt
     7861 ctccagcaag gtgcgccggg tgccgccgag cgggccgcgc gtcaccaggt gcaccagcgg
     7921 gtacaccgtg ccgtccgcgg tcgccgcgag aatccgcgcc tcgtccggca cgacctgacg
     7981 cagcacggcg gcgaacaggt agtcccggct ggcctcgcgg ccgtaggtga ccgacgcgct
     8041 cagcaactcg gccatcgcgg cgcgtagcgg ctcgacgagt tgtgcgggtg atccgttgcc
     8101 ggagtcggtg acctcgccct cgatcgcctg ccgccgccag ccggccgtgc gctccggcga
     8161 ggccagcgcg ttgcccgggt agtcgaggcg cttgcgcacc tcgtccacca cggcgtattc
     8221 gagtcgtttg agctggcgat cggcgatgtc gccaccgggc agcttctttg tgacgttcca
     8281 gccggccttg gccagccagc cggccgcccg cccggcaccg gtgatcaggc cgtccacgtc
     8341 cggccgcgat cgtcgctcct ccacggggat tggtgtacca caggtgacgt gagccagaac
     8401 ctcgacgccg tcacatcggc cgcctccgcc gccttccgcg acgagtgggg ccagatcgtc
     8461 gccacgctga tcaggatcac cggcgactgg gacctcgccg aggagtgcgc gcaggaggcg
     8521 ttcgcccagg cgctgaccgc gtgggcgcgc gacggcgtgc cgcgcaagcc gggcgcgtgg
     8581 ctgaccacgg cggcgcgcaa ccgggcgacc gaccggctgc gccgcgaggc cgtcggcgcg
     8641 gccaagctgc gcgagctggc cgcgatgaca ccggtcgccc agccggacgg caccgcctac
     8701 gacagggacg acgacagcgg cgtgtcggac gaccggctgc ggctgatctt cacctgctgc
     8761 caccccgcgc tgccgttcga gtcgcgggtg gcgctgaccc tgcgcacgct ggccggcctg
     8821 acgaccgcgg agatcgcgcg cgcgttcctg gtcgtcgagc aggcgatgca gcagcggatc
     8881 gtgcgggcca agcgcaagat ccgcaacgcg aagatcccgt accgggtgcc gccggcgcac
     8941 ctgctgccgg agcgcacgtc ggccgtgctc ggcgtgctgt acctgctgtt caacgagggg
     9001 tacacggcca cggccggcgc ggatctggtg cggcacgggc tcatcgcgga ggcggtccgg
     9061 ctggcgcgca tgctggcccg gctgatgccg gaggagacgg aggcgcgcgg gctgctcgcg
     9121 ctgatgctgc tgcacgacgc gcgccgggcg acccggctgg ggccggacgg cgagctggtg
     9181 ctgctcgagg atcaggaccg cacgcggtgg gacgccgagg agatcgccga gggtgtggcg
     9241 ctgctggagc gcacgctggc ggccggtcgg ccggggccgt accaggtgca ggcggcgatc
     9301 gccgcgtgtc acgcgaccgc gcgcaccgcg gcggagaccg actgggtgca gatcgcggcg
     9361 ctgtacgggc agctcgcccg gttcgtgccg tcggcggtcg tggagctgaa ccgggccgtc
     9421 gcggtgggca tggcggacgg gccggcggcg gggctcgtgc tggtggattc gttgcgggac
     9481 aagggagatc tcgacgggta ccacctgctg ccggcgactc gcgcggactt tctacggcgg
     9541 ctcggacgtg acgacgaggc ggccgcggag taccgcgcgg cgctggagct ggcgggcacc
     9601 gacgccgagc gccggttcct cacgtcacgg ctcgctgagg tcacccgttg acatgtgacc
     9661 ttttggtcac ctatccttcg tcgcgtgacg gacgacgaca aagtcctcga tgacgcagtc
     9721 ttcaaggcgc tggccgatcc cacccgtcgc ttcttgctcg acctgctgtt cgcgcgtgac
     9781 ggccgcacgc tcaccgaact cgagtcggag ctggagatgt cgcgcttcgg cgtgatgaag
     9841 catctgcgcg tgctcgagga ggcggatctc gtcgtcacgc gcaaatcggg ccgggagaag
     9901 ttccactaca tcaacccgat cccgatccgg ctgatccacg accggtggat cgacaagtac
     9961 accgagcgac gggcatccgc gctggcggac ctcaaaaggc aactggagca ggaacaatga
    10021 cgaacgcgac gaagaccgag accacccaga tctacagcgt ctacatcaag gccgacgcga
    10081 agaaggtgtg ggacgcgatc acccagcgcg aatggaccga gaagtacggc tacggcgggt
    10141 acgcggacta cagcaagggc accggacgat tcgagacgca cccgagccag gacatgatcg
    10201 acgccggcaa ggcgaacggc tacgagatcc ctgacgtgat catcgagggc gagatcctgg
    10261 cgtacgaccc gcccacgaag ctggcgctga cctggcacat gctgatggac ccggagaccg
    10321 ccaaggagag cttcaccaag ctcacctacg agatcaagga ggtccccggc ggggtaaagc
    10381 tgaccgtcac ccacgacctg gagggtgcgc cggtactggc cgcggtcacc tccgg
//
