GCF_004135345.1 - 3 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP035495.1 (Xylanimonas allomyrinae)

Region	Type	From	To
Region 1.1	lanthipeptide-class-v,lanthipeptide-class-ii	890,984	934,012
Region 1.2	terpene-precursor	1,349,948	1,371,045
Region 1.3	polyhalogenated-pyrrole	3,627,739	3,663,877

Region	Type	From	To
Region 1.1	lanthipeptide-class-v,lanthipeptide-class-ii	890,984	934,012
Region 1.2	terpene-precursor	1,349,948	1,371,045
Region 1.3	polyhalogenated-pyrrole	3,627,739	3,663,877

No secondary metabolite regions were found in these records:: NZ_CP035496.1 (Xylanimonas allomyrinae)

Compact view

NZ_CP035495.1 - Region 1 - lanthipeptide-class-ii,lanthipeptide-class-v

Download region GenBank file

Download region SVG

Location: 890,984 - 934,012 nt. (total: 43,029 nt) Show pHMM detection rules used

lanthipeptide-class-v: (APH and HopA1)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

ET495_RS04090: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acetyltransferase

ET495_RS03985: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Lyases: cyclase

ET495_RS04135: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000517.4	0.43	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.42	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000554.4	0.38	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.36	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001210.5	0.35	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.35	ribosomal	thuricin	Bacillus thuringiensis
BGC0000563.4	0.34	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001311.5	0.34	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0001229.4	0.33	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000539.5	0.33	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000517.4	0.55	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001210.5	0.49	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.49	ribosomal	thuricin	Bacillus thuringiensis
BGC0000563.4	0.48	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001311.5	0.48	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0001229.4	0.48	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000528.5	0.48	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ET495_RS04135

ET495_RS04095

Leader:

MDQPAILVPAVVLAAA

ET495_RS04095

Leader:

MDQPAILVPAVVLAAA

Shared core:

FVVYCYVELARATEVRFLPKWGWAVAVAISVPLGGIVYLLAGRSETGSDA

Core with dehydrations:

FVVYCysYVELARADhbEVRFLPKWGWAVAVAIDhaVPLGGIVYLLAGRDhaEDhbGDhaDA

antiSMASH-DB 4.0 matches for ET495_RS04095

100.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: ET495_RS04095_lanthipeptide

Lanthipeptides: ET495_RS04095_lanthipeptide

FVVYCYVELARATEVRFLPKWGWAVAVAISVPLGGIVYLLAGRSETGSDA

12.0%

NZ_KB235919.1:

Lanthipeptides: allorf_340400_340522_lanthipeptide

RFLPKWG

RFLPK+G

RFLPKFG

ET495_RS17535

Leader:

MNNAYAAAGDVTLELTAHQVDAEADATAGG

ET495_RS17535

Leader:

MNNAYAAAGDVTLELTAHQVDAEADATAGG

Shared core:

LWTIPGTSTIGRFCTLSWECQGIACG

Core with dehydrations:

LWDhbIPGDhbDhaDhbIGRFCysDhbLDhaWECysQGIACysG

antiSMASH-DB 4.0 matches for ET495_RS17535

100.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide

Lanthipeptides: ET495_RS17535_lanthipeptide

LWTIPGTSTIGRFCTLSWECQGIACG

62.1%

NZ_LR027842.1:

Lanthipeptides: E0E39_RS15855_lanthipeptide

LWTIPGTSTIGRFCTLSWECQGIACG

LWT+PGT TIG CT+SWEC G CG

LWTVPGTRTIGAVCTVSWECHGFICG

55.2%

NZ_CP025227.1:

Lanthipeptides: allorf_0999194_0999376_lanthipeptide

LWTIPGTSTIGRFCTLSWEC

LWT+P TSTIG CTLSWEC

LWTVPTTSTIGLVCTLSWEC

with 90 more sequence matches

Only the first 10 are displayed here.

53.1%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15160_lanthipeptide

Lanthipeptides: HGK68_RS15160_lanthipeptide

LWTIPGTSTIGRFCTLSWECQGIAC

+WTIPGT TIG FCT+S+EC G C

IWTIPGTKTIGAFCTISYECWGFVC

50.0%

NC_014643.1and 2 others:

NZ_KV795763.1 Lanthipeptides: HMPREF2554_RS11600_lanthipeptideNZ_KV804818.1 Lanthipeptides: HMPREF2804_RS11135_lanthipeptide

Lanthipeptides: HMPREF0733_RS11155_lanthipeptide

LWTIPGTSTIGRFCTLSWECQGIACG

L+T+PGT+T+G FCT+SWEC G CG

LFTVPGTTTVGHFCTISWECSGFICG

48.4%

NZ_QGGR01000002.1:

Lanthipeptides: BC793_RS05490_lanthipeptide

LWTIPGTSTIGRFCTLSWECQ

L+T+PGTSTIG CT+SWEC

LYTVPGTSTIGWICTVSWECS

45.2%

NZ_PVMZ01000043.1and 1 other:

NZ_PVMZ01000043.1 Lanthipeptides: CLV67_RS49720_lanthipeptide

Lanthipeptides: CLV67_RS49720_lanthipeptide

LWTIPGTSTIGRFCTLSWECQ

L+T+PGTSTIG CT S+EC

LFTVPGTSTIGYVCTYSYECS

38.9%

NZ_JAPVBQ010000001.1:

Lanthipeptides: O2V63_RS05740_lanthipeptide

LWTIPGTSTIGRFCTLSWECQGIACG

L+T T T+G CT+SWEC G CG

LFTFKTTKTVGAVCTISWECSGRICG

38.5%

NC_016582.1and 1 other:

NC_016582.1 Lanthipeptides: SBI_RS34375_lanthipeptide

Lanthipeptides: SBI_RS34375_lanthipeptide

GTSTIGRFCTLSWECQ

G G FCTLS ECQ

GNGGFGLFCTLSKECQ

38.5%

NZ_BORO01000007.1:

Lanthipeptides: KI343_RS07745_lanthipeptide

WTIPGTSTIGRFCTLSWEC

WT+PG G CTL+ EC

WTLPGG---GGVCTLTSEC

37.0%

NZ_CP071875.1:

Lanthipeptides: J4I02_RS02880_lanthipeptide

IPGTSTIGRFCTLSWECQG

IP S G CTL+ EC G

IPNHSG-GAICTLTHECAG

34.6%

NC_009480.1and 10 others:

NZ_CP033724.1 Lanthipeptides: EFE39_RS10220_lanthipeptideNZ_CP047051.1 Lanthipeptides: GRD74_RS10365_lanthipeptideNZ_CP047054.1 Lanthipeptides: GRD61_RS10460_lanthipeptideNZ_CP053860.1 Lanthipeptides: DQP62_RS10825_lanthipeptideNZ_CP076352.1 Lanthipeptides: KN218_RS09900_lanthipeptideNZ_CP085137.1 Lanthipeptides: LHJ48_RS10290_lanthipeptideNZ_CP085140.1 Lanthipeptides: LHJ47_RS10305_lanthipeptideNZ_CP095274.1 Lanthipeptides: MU580_RS10460_lanthipeptideNZ_PSTW01000024.1 Lanthipeptides: C5C03_RS09675_lanthipeptideNZ_SISU01000002.1 Lanthipeptides: EOG37_RS09890_lanthipeptide

Lanthipeptides: CMM_RS10575_lanthipeptide

STIGRFCTLSWECQGIACG

S+ G CTL+ EC I C

SSSGWLCTLTIECGTIICA

34.6%

NC_017912.1and 14 others:

NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptideNZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptideNZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptideNZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptideNZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptideNZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptideNZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptideNZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptideNZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptideNZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptideNZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptideNZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide

Lanthipeptides: MUS_RS20065_lanthipeptide

WTIPGTSTIGRFCTLSWEC

+T+PG G CTL+ EC

FTLPGG---GGVCTLTSEC

MIBiG 4.0 matches for ET495_RS17535

23.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GRFCTLSWECQ

G +CTL+ ECQ

GGWCTLTKECQ

23.1%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

IGRFCTLSWECQGIACG

+G L+ C GI+C

VGLLTLLNTVCIGISCA

21.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GRFCTLSWECQ

G +CTL+ EC

GAYCTLTVECM

with 1 more sequence matches

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLSWECQ

CTLS ECQ

CTLSKECQ

allorf_0927515_0927718

Leader:

MSRYRGADSGNCSERGSTHGG

allorf_0927515_0927718

Leader:

MSRYRGADSGNCSERGSTHGG

Shared core:

TDRRHIDSRRSDRCALCLLFQAPSRGLATAPSCAARQYDHNARFGS

Core with dehydrations:

DhbDRRHIDDhaRRDhaDRCysALCysLLFQAPDhaRGLADhbAPDhaCysAARQYDHNARFGDha

antiSMASH-DB 4.0 matches for allorf_0927515_0927718

100.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: allorf_0927515_0927718_lanthipeptide

Lanthipeptides: allorf_0927515_0927718_lanthipeptide

TDRRHIDSRRSDRCALCLLFQAPSRGLATAPSCAARQYDHNARFGS

28.3%

NZ_CP023690.1:

Lanthipeptides: allorf_9606496_9606669_lanthipeptide

SRRSDRCALCLLFQAPSRGLATAPSCAARQ

S R +R A C P R A APS AR+

SARPERAASCPTPSGPRRPRAIAPSGRARK

15.2%

NZ_AP023359.1:

Lanthipeptides: Prubr_RS32600_lanthipeptide

FQAPSRGLATAPS

+ PSR ATAP+

WLVPSRSYATAPA

MIBiG 4.0 matches for allorf_0927515_0927718

17.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

HIDSRRSDRCALCLLFQAPSRGLATAPSC

+I R ++ A C L + PSC

NISCRLGNKGAYCTL------TVECMPSC

allorf_0930927_0931019

Leader:

MSGGATQLPGA

allorf_0930927_0931019

Leader:

MSGGATQLPGA

Shared core:

CWLGRWRTLVTRVDVTACV

Core with dehydrations:

CysWLGRWRDhbLVDhbRVDVDhbACysV

antiSMASH-DB 4.0 matches for allorf_0930927_0931019

100.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: allorf_0930927_0931019_lanthipeptide

Lanthipeptides: allorf_0930927_0931019_lanthipeptide

CWLGRWRTLVTRVDVTACV

22.7%

NZ_CP053549.1and 3 others:

NZ_JADKSM010000003.1 Lassopeptides: ITJ61_RS18070_lassopeptideNZ_PSXX01000017.1 Lassopeptides: C5E05_RS18625_lassopeptideNZ_PSXZ01000003.1 Lassopeptides: C5E07_RS02640_lassopeptide

Lassopeptides: HMI60_RS00570_lassopeptide

CWLGRWRTL

W GRWR +

VWFGRWRDI

18.2%

NZ_JADG01000011.1:

Lanthipeptides: P696_RS0120030_lanthipeptide

LGRWRTLVTRVDVTAC

LG W V VD+ AC

LGYWTEGVAAVDIYAC

with 1 more sequence matches

14.5%

NZ_BMRD01000003.1and 1 other:

NZ_JANBBD010000039.1 Lanthipeptides: BS35_RS35910_lanthipeptide

Lanthipeptides: IEZ14_RS08160_lanthipeptide

LGRWRTLVTRVDVTACV

LG W V VD AC

LGYWTEGVAAVDAYACA

allorf_0931728_0931856

Leader:

MPSGDSVAALAAA

allorf_0931728_0931856

Leader:

MPSGDSVAALAAA

Shared core:

CRRARDAAGQRSGAQRRRPGSRRPQYPSP

Core with dehydrations:

CysRRARDAAGQRDhaGAQRRRPGDhaRRPQYPDhaP

antiSMASH-DB 4.0 matches for allorf_0931728_0931856

100.0%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: allorf_0931728_0931856_lanthipeptide

Lanthipeptides: allorf_0931728_0931856_lanthipeptide

CRRARDAAGQRSGAQRRRPGSRRPQYPSP

30.0%

NZ_JACHJY010000017.1:

Lanthipeptides: GGE06_RS39690_lanthipeptide

ARDAAGQRSGAQRRRPGSRRPQYPSP

A +R+ A RP +R P +P P

ALSLVDRRALALTTRPANRCPAFPPP

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 24.07 out of 30.11

Confidence: medium

Additional weak hits (11):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.76 out of 23.43

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.74 out of 30.22

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.19 out of 24.78

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.90 out of 20.01

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.44 out of 26.85

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.25 out of 27.18

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.93 out of 28.14

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.43 out of 27.18

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

ET495_RS04095 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 5308.9 Da

Molecular weight: 5312.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5330.1 Da N = 1; 5348.2 Da N = 2; 5366.2 Da N = 3; 5384.2 Da N = 4

ET495_RS17535 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 2691.3 Da

Molecular weight: 2693.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2711.1 Da N = 1; 2729.1 Da N = 2; 2747.2 Da N = 3

allorf_0927515_0927718 - Class II

Cleavage pHMM score: -1.10

RODEO score: 0

Monoisotopic mass: 5019.5 Da

Molecular weight: 5022.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5040.6 Da N = 1; 5058.6 Da N = 2; 5076.6 Da N = 3; 5094.6 Da N = 4

allorf_0930927_0931019 - Class II

Cleavage pHMM score: -2.40

RODEO score: 0

Monoisotopic mass: 2179.2 Da

Molecular weight: 2180.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2198.6 Da N = 1

allorf_0931728_0931856 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3238.7 Da

Molecular weight: 3240.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3258.6 Da N = 1; 3276.6 Da N = 2

ET495_RS04095 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 5308.9 Da

Molecular weight: 5312.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5330.1 Da N = 1; 5348.2 Da N = 2; 5366.2 Da N = 3; 5384.2 Da N = 4

ET495_RS17535 - Class II

Cleavage pHMM score: 0.50

RODEO score: 0

Monoisotopic mass: 2691.3 Da

Molecular weight: 2693.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2711.1 Da N = 1; 2729.1 Da N = 2; 2747.2 Da N = 3

allorf_0927515_0927718 - Class II

Cleavage pHMM score: -1.10

RODEO score: 0

Monoisotopic mass: 5019.5 Da

Molecular weight: 5022.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5040.6 Da N = 1; 5058.6 Da N = 2; 5076.6 Da N = 3; 5094.6 Da N = 4

allorf_0930927_0931019 - Class II

Cleavage pHMM score: -2.40

RODEO score: 0

Monoisotopic mass: 2179.2 Da

Molecular weight: 2180.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2198.6 Da N = 1

allorf_0931728_0931856 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3238.7 Da

Molecular weight: 3240.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3258.6 Da N = 1; 3276.6 Da N = 2

TFBS definitions

Regulator	Description
CelR	Cellobiose uptake repressor
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP035495.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,349,948 - 1,371,045 nt. (total: 21,098 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acyltransferase

ET495_RS06260: acyltransferase

smcogs: SMCOG1141: acyltransferase

Ligases: ligase synthetase

ET495_RS06235: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

ET495_RS06275: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000936.5	0.37	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.36	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.36	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002274.2	0.56	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002193.2	0.56	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000936.5	0.37	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1
BGC0001456.3	0.37	terpene	isorenieratene	Streptomyces argillaceus
BGC0001910.4	0.36	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.36	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.36	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

ET495_RS06235: PT_FPPS_like

Domain 1 (47 - 352): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (5):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.55 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.97 out of 30.22

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.30 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.00 out of 33.14

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.83 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_CP035495.1 - Region 3 - polyhalogenated-pyrrole

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Location: 3,627,739 - 3,663,877 nt. (total: 36,139 nt) Show pHMM detection rules used

polyhalogenated-pyrrole: (Abhydrolase_6 and Trp_halogenase and (Acyl-CoA_dh_N or Acyl-CoA_dh_M or Acyl-CoA_dh_1) and AMP-binding)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

ET495_RS16505: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

ET495_RS16520: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: halogenase kinase

ET495_RS16510: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

ET495_RS16550: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: hydrolase peptidase

ET495_RS16480: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

ET495_RS16485: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

ET495_RS19540: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: dehydratase

ET495_RS16525: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

Ligases: ligase

ET495_RS16540: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.55	NRPS	HC-toxin	Alternaria jesenskae
BGC0002193.2	0.55	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000649.3	0.44	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000259.3	0.42	PKS	prodigiosin	Serratia marcescens
BGC0002071.2	0.41	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002675.2	0.41	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0000260.3	0.41	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0002514.3	0.41	PKS	julichrome Q6.6	Streptomyces sampsonii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.55	NRPS	HC-toxin	Alternaria jesenskae
BGC0002193.2	0.55	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000649.3	0.44	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000259.3	0.42	PKS	prodigiosin	Serratia marcescens
BGC0002071.2	0.41	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002675.2	0.41	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0000260.3	0.41	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0002514.3	0.41	PKS	julichrome Q6.6	Streptomyces sampsonii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (10):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.58 out of 30.25

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.43 out of 27.04

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.96 out of 29.38

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.12 out of 27.55

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.64 out of 29.51

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.88 out of 29.65

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.53 out of 32.93

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.48 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.85 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description