LOCUS       NZ_CP033336            24230 bp    DNA     circular CON 03-APR-2024
DEFINITION  Streptococcus pyogenes strain TSPY165 chromosome, complete genome.
ACCESSION   NZ_CP033336
VERSION     NZ_CP033336.1
KEYWORDS    RefSeq.
SOURCE      Streptococcus pyogenes
  ORGANISM  Streptococcus pyogenes
            Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
            Streptococcus.
REFERENCE   1  (bases 1 to 1812036)
  AUTHORS   Macias,O.R., Shah,B.J., Hanson,B., Sanson,M.A. and Flores,A.R.
  TITLE     Complete genome sequences of group A Streptococcus emm types
            frequently associated with antibiotic resistance
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1812036)
  AUTHORS   Macias,O.R., Shah,B.J., Hanson,B., Sanson,M.A. and Flores,A.R.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-OCT-2018) Pediatrics, UTHSC/McGovern Medical School,
            6431 Fannin St., MSB 3.130, Houston, TX 77030, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 10-JAN-2018
            Assembly Method :: Unicycler v. 0.4.6; Canu v. 1.7.1
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 263.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004124135.1-RS_2024_04_03
            Annotation Date                   :: 04/03/2024 02:58:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,798
            CDSs (total)                      :: 1,709
            Genes (coding)                    :: 1,656
            CDSs (with protein)               :: 1,656
            Genes (RNA)                       :: 89
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 67
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 53
            CDSs (without protein)            :: 53
            Pseudo Genes (ambiguous residues) :: 0 of 53
            Pseudo Genes (frameshifted)       :: 31 of 53
            Pseudo Genes (incomplete)         :: 23 of 53
            Pseudo Genes (internal stop)      :: 18 of 53
            Pseudo Genes (multiple problems)  :: 17 of 53
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:19:50
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 984434
            Orig. end                         :: 1008664
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP033336.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Anthony R. Flores, MD, MPH,
            PhD.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24230
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24230
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24230
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14230](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..14230)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(196..996)
                     /gene="folP"
                     /locus_tag="EB817_RS05145"
                     /old_locus_tag="EB817_05150"
     CDS             complement(196..996)
                     /EC_number="2.5.1.15"
                     /GO_function="GO:0004156 - dihydropteroate synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009396 - folic acid-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="folP"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407558.1"
                     /locus_tag="EB817_RS05145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05150"
                     /product="dihydropteroate synthase"
                     /protein_id="WP_129304727.1"
                     /transl_table=11
                     /translation="MKIGKFVIEGNAAIMGILNVTPDSFSDGGAYTTVQKALDHVEQMI
                     ADGAKIIDVGGESTRPGCQFVSATDEIDRVVPVIKAIKENYDILISIDTYKTETARAAL
                     EAGADILNDVWAGLYDGQMFALAAEYDAPIILMHNQDEEVYQEVTQDVCDFLGNRAQAA
                     LDAGVPKNNIWIDPGFGFAKSVQQNTELLKRLDRVCQLGYPVLFGISRKRVVDALLGGN
                     TKAKERDGATAALSAYALGKGCQIVRVHDVKANQDIVAVLSQLM"
     gene            complement(1005..1571)
                     /gene="folE"
                     /locus_tag="EB817_RS05150"
                     /old_locus_tag="EB817_05155"
     CDS             complement(1005..1571)
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989871.1"
                     /locus_tag="EB817_RS05150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05155"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_338323371.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 6.1e-77,
                     bitscore: 253.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSINKEKAEAAIYQFLEAIGENPKREGLLDTPKRVAKMYAEMFLG
                     LGKDPKEEFTAVFKEQHEDVVIVKDISFYSICEHHLVPFYGKAHIAYLPSDGRVTGLSK
                     LARAVEVASKRPQLQERLTSQIADALVEALNPKGTLVMVEAEHMCMTMRGIKKPGSKTI
                     TTTARGLYKESRAERQEVISLMTKD"
     gene            complement(1624..2901)
                     /locus_tag="EB817_RS05155"
                     /old_locus_tag="EB817_05160"
     CDS             complement(1624..2901)
                     /EC_number="6.3.2.-"
                     /GO_function="GO:0004326 - tetrahydrofolylpolyglutamate
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008841 - dihydrofolate synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006730 - one-carbon metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002995327.1"
                     /locus_tag="EB817_RS05155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05160"
                     /product="folylpolyglutamate synthase/dihydrofolate
                     synthase family protein"
                     /protein_id="WP_129304731.1"
                     /transl_table=11
                     /translation="MTYEETLEWIHDHLVFGIKPGLKRMLWVLGQLGNPQKNVKGVHIV
                     GTNGKGSTVNHLQHIFTTAGYEVGTFTSPYIMDFKERISINGRMISEKDLVIAANRIRP
                     LTERLVQETDFGEVTEFEVITLIMFLYFGDMHPVDIAIIEAGLGGLYDSTNVFQAMVVV
                     CPSIGLDHQAILGETYADIAAQKAGVLEGGETLVFAVENPSAREVFLTKAEQVGASIWE
                     WQEQFQMAENASGYRFTSPLGVISDIHIAMPGHHQVSNAALAIMTCLTLKDRYPRLTPD
                     HIREGLANSLWLGRTELLAPNLMIDGAHNNESVAALVAVLKNNYNDKKLHILFGAIDTK
                     PIADMLVALEQIGDLQVTSFHYPNAYPLEKYPERFGRVADFKDFLALRKHAKADDFFVI
                     TGSLYFISEIRQYWKKHIEKSVLLTH"
     gene            3233..4195
                     /locus_tag="EB817_RS05160"
                     /old_locus_tag="EB817_05165"
     CDS             3233..4195
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014407556.1"
                     /locus_tag="EB817_RS05160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05165"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_023079412.1"
                     /transl_table=11
                     /translation="MNNRHKRRQKRKAFTLINLILLFACILGLTLIFYLYQGSNKFGLS
                     DVSQFVPKISLFHHKKTAKKETTKLKKTHFNSSKSQKKAHSKLTWTKQETPVKIPILMY
                     HAIHVMSPEETANANLIVNPDLFDQQLQKMKDEGYYFLSPEEVYRALSNNELPAKKVVW
                     LTFDDSMIDFYNVAYPILKKYDAKATNNVITGLTEMGSAANLTLKQMKEMKQFGMSFQD
                     HTVNHPDLEQASPDVQTTEMKDSKDYLDKQLNQNTIAIAYPSGRYNDTTLQIAARLNYK
                     LGVTTNEGIASAANGLLSLNRIRILPNMSPENLLQTMEP"
     gene            complement(4311..5546)
                     /gene="pbp3"
                     /locus_tag="EB817_RS05165"
                     /old_locus_tag="EB817_05170"
     CDS             complement(4311..5546)
                     /EC_number="3.4.16.4"
                     /codon_start=1
                     /gene="pbp3"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922278.1"
                     /locus_tag="EB817_RS05165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05170"
                     /product="D-alanyl-D-alanine carboxypeptidase PBP3"
                     /protein_id="WP_129304733.1"
                     /transl_table=11
                     /translation="MIKRWVILFFMVLTCSGFGKTVLAADFQVGAEHAIVVEADSGRVL
                     YEKDAKTPDAIASLTKLVTAYLVLDKVKSGQLQLSDQVNLSDYAFELTKDRSLSNVPFD
                     KKTYSVQDLLTATLVASSNSAAIALAEKVAGSEPHFVNQMREQLSHWGITFGKILNASG
                     LPNEVLKDNRYPGSALEEENTLSAQDVAVVTMHLLEDFPEILEITKQTEVNFAGNSIKS
                     FNQLLPGMAKGRAGVDGLKTGTTDLAGHCLVVTSIENGMRVITVILNADGSDKNQNTRF
                     EQANRLLDYVARTYCRRKILKKGSLVSERSLPIQDGQVKELPVSVAGDVTIILQQGEQV
                     PKPKQFMISETSLLAPITKGEVVAYLTSPRITDQSVRYLKEPKRIPLKASQSLKKASDL
                     QLWWRDFLEKRR"
     misc_feature    complement(5654..5666)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 18.96"
                     /tool="antismash"
     gene            complement(5704..6891)
                     /locus_tag="EB817_RS09600"
                     /old_locus_tag="EB817_05175"
                     /pseudo=""
     CDS             complement(5704..6891)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106750.1"
                     /locus_tag="EB817_RS09600"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05175"
                     /product="site-specific integrase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIKNQKKYKGVYCDKNGKIFYQADLGVDPVTGKRVQKKARKN"
     gene            complement(6894..7115)
                     /locus_tag="EB817_RS05175"
                     /old_locus_tag="EB817_05180"
     CDS             complement(6894..7115)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003106749.1"
                     /locus_tag="EB817_RS05175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05180"
                     /product="DUF3173 family protein"
                     /protein_id="WP_021299413.1"
                     /transl_table=11
                     /translation="MNIGFLEHTARDIIREAKRIAIKKFEEAREIDQNAVQLSKSPFDN
                     RRLGIAPKDIVEELIGILLSEESLESEN"
     misc_feature    7129..7144
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.55"
                     /tool="antismash"
     misc_feature    7155..7171
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.88"
                     /tool="antismash"
     gene            7202..7345
                     /locus_tag="EB817_RS09275"
     CDS             7202..7345
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003042734.1"
                     /locus_tag="EB817_RS09275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_021299391.1"
                     /transl_table=11
                     /translation="MGISPTGLLRWQPERSEVSLSLFVVMADREPLYFIANNYRSYHGV
                     SH"
     gene            complement(7416..7634)
                     /locus_tag="EB817_RS05185"
                     /old_locus_tag="EB817_05190"
     CDS             complement(7416..7634)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984785.1"
                     /locus_tag="EB817_RS05185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05190"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_002989884.1"
                     /transl_table=11
                     /translation="MYPRIRNLREDNDFTQKFVANLLSFSHANYAKIERGEVALMADVL
                     VQFSKLYNVSIDYLLGQTDYPYRFHNK"
     misc_feature    7593..7604
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.71"
                     /tool="antismash"
     gene            complement(7826..8548)
                     /locus_tag="EB817_RS05190"
                     /old_locus_tag="EB817_05195"
     CDS             complement(7826..8548)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922276.1"
                     /locus_tag="EB817_RS05190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05195"
                     /product="lantibiotic immunity ABC transporter MutG family
                     permease subunit"
                     /protein_id="WP_011528613.1"
                     /transl_table=11
                     /translation="MKSYLCSNFLKIKNTSYLLIHILAALLFPLLLFFYWSQRGGLQSR
                     TVLFSYFQIVGVLLPFVASIVCIQLKNLEESSGKYKYLLGYSQSNYKPFIVELVFLWLC
                     YCIVLIISITIFILLLKTIGINVSLRLLILNSLIYIIFAYVTYLINHIISYIFSTGVAL
                     GISMVGVIAAAFCETSLGDKVWFLIPWAWLLRISDTLYNQQKMAIVPLIVIFFVSCTVA
                     LLHIRIFKSWNQDCLTSS"
     gene            complement(8551..9300)
                     /locus_tag="EB817_RS05195"
                     /old_locus_tag="EB817_05200"
     CDS             complement(8551..9300)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984791.1"
                     /locus_tag="EB817_RS05195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05200"
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_010922275.1"
                     /transl_table=11
                     /translation="MVQIFLSNLLKIKNTSISKLILIFPIICVMLSLLFSALGGENILR
                     LTAETTVNQWGVIWINVIIAVNSGLLNKLELDSNKYSVFLSRDVDLKKVEYARVLLIAL
                     INLIISMILSLMLIVISFVLPTPSLISIGRILLTILLIWLTTLWQIPFILWLSRKINVY
                     FAMIINIISPLIIGTSFSLLNKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQI
                     FISLFLGIAFFILLTNLFAISFKKQVK"
     gene            complement(9306..9995)
                     /locus_tag="EB817_RS05200"
                     /old_locus_tag="EB817_05205"
     CDS             complement(9306..9995)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010922274.1"
                     /locus_tag="EB817_RS05200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05205"
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_129304735.1"
                     /transl_table=11
                     /translation="MLKIQNLKKSYGKRTILNNVNMNISKGKVYALIGPNGAGKSTIMK
                     ILTGLVSKTSGSIIFEGREWSRRDLRKIGSIIEEPPLYKNLSAYDNMKVVTTMLGVSES
                     TILPLLNKVGLGNIDKRPVKQFSLGMKQRLGIAISLINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSEGMTIMISSHILSEVEHLADFIGFIYEGKIILEKEYDGSENLEELFNNQ
                     ILFEKRR"
     gene            complement(10001..12967)
                     /locus_tag="EB817_RS05205"
                     /old_locus_tag="EB817_05210"
     CDS             complement(10001..12967)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528611.1"
                     /locus_tag="EB817_RS05205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05210"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_164976429.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.4e-90, bitscore:
                     299.3, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.6e-11,
                     bitscore: 41.5, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.9e-13, bitscore:
                     47.3, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKVFPTGMIRIPLQKQEFYNKDYEDLINDKVFMEQLLVASPSLY
                     DSVIDFDKCNEKKKQNVKVSLNSYSKRAAFRTTPFGIFTAINTVDLTKGTTSNVQKVSF
                     IKKAVPDYSWIYSLVKSYEISNLEKLSLKINTAAFTQGDRYVLPFTVNESEEDRNISFS
                     KPIKLLVEKCKTRYIKYEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPPICN
                     INSLDYLLSKLEEGTLCTDLTTLKKMIEDYNDLNIGEGRDLLLQIFDKMESIYKYDNGG
                     NYLKVDSLAEYEGGFNILSETARESIERLAEMFVKLNTNVKRRGGRKNSLEEYQLKFIG
                     KYGENCSIPFVEVINKDAGIGFPEYYKGGEGEAIELSDPIMQMFEKKYEEALLNGGHIE
                     FYSKDLDDFQTDQSNSLDSFELNFNIKIINNDVKLYLGANIGSGQAGRSFGRFYGLSET
                     VRETIKNLNHQNNTNVELSFVPKQIRLANVIQNYSDESYNTSFFTTSWDSENELRLEDI
                     YIRYSDGKFHFTTIDGKNELKFTMNNMLNSDSQSRVLRLLVDLSEFEYGLSHWSLFPWD
                     ILAQERVYIPEILFEDITIATAQWNLSVIREEIIHQKIFTGKKDIFNKFRKTYKIPKDI
                     ILKYADNELRLDLSIDSDLEILFKNINKYRFVSLRGIEQGESIFKDNLGNYNTEIVVPI
                     LKESNGINNTNDNVQFKNEVKKIYLPFCDWLFFKFYGPKERQEELLNNWKKFWLNLPSE
                     LFSQSNMFYMRYNDTNDHIRIRINCDSIENNFSFYLSVVQDLLPQLIESCIISDIEVSS
                     YKPEVNRYGGPHLISYAEEIFCKESILFLNNTIEFSDDERLVCATYLVLYYLNHFFKDK
                     ETRRSFLFENYTGKYKKDFKNLPIDLPIEYMKILNGVTSALDRYDFFQEMDRYLMSYMK
                     EYNRFGGTNDIYNTKFNLVGSFLHLSMNRLNGIDREFEEKVYCFAYYTLNAQQYIEWE"
     aSDomain        complement(12311..12565)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EB817_RS05205_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="2.60E-13"
                     /identifier="RREFam001.1"
                     /label="EB817_RS05205"
                     /locus_tag="EB817_RS05205"
                     /protein_end="219"
                     /protein_start="134"
                     /score="41.5"
                     /tool="antismash"
                     /translation="NTAAFTQGDRYVLPFTVNESEEDRNISFSKPIKLLVEKCKTRYIK
                     YEELIDVFKNNYPDIVSDMLESYIHDLVTNDFLISDLRPP"
     gene            complement(12986..14230)
                     /locus_tag="EB817_RS05210"
                     /old_locus_tag="EB817_05215"
     CDS             complement(12986..14230)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002989896.1"
                     /locus_tag="EB817_RS05210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05215"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_129304737.1"
                     /sec_met_domain="LANC_like (E-value: 1.2e-76, bitscore:
                     254.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIKQIVDYIADSFINYEQIVAESENKVLINIESKYRNTFFDK
                     SLSHGVPSLILMYSSLYKVTKDERYLTFSNIYVEKLVDIISRDGIESPSLYAGTAGIAL
                     AIKEASISGKYYPKLLSSLNCLLKEQIKDKLVVSFSNIEKGIIEPYDYDMVNGFSGITN
                     YLLLEQEFFSVELNQIGNYLLKYIETILNKVTNCSEDREAEFDLGIAHGITGPMLILAK
                     LKSEKILSVEVGDILNKAINLMFLFRRDDKLWPGKIYTSNILDLDLNYLPTRMAWCFGT
                     PGTAVALFKMCQLIDLNFIDDINESLIAQMRSSDKNVYSLTMCHGLAGVTFIYDLIGKN
                     YSSERLTRFAEELRQQIITSFSTTKVFGYTDREKFGEIEVELESIGILQGVSGIVLFLL
                     NPYSDEELLWQRIFI"
     gene            complement(14214..16004)
                     /locus_tag="EB817_RS05215"
                     /old_locus_tag="EB817_05220"
     CDS             complement(14214..16004)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019418808.1"
                     /locus_tag="EB817_RS05215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05220"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_011284758.1"
                     /transl_table=11
                     /translation="MIKAQLKNLIKTIHLVKEAGFSLLVFSIAISLFQGILPIFSMLLV
                     QKMLNIITTDIKNFHTLMIAFISYIALTLLTIIIGEVDSYIDTKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSLISSFVILLNWKI
                     SIFPLLLILPIVSIYIYLKIGKNEFEILYKRSSDERANWYISHLLTHDFAVKELRLGTL
                     ESYFLKKYDKNNQLFINQENSINRSKMKYGIVLGVLEIAIQSIIMFLAVREAFLGILLV
                     GNVTTFIRSLSTMQTSTQNIVNNIYSFYNGSLYMELLYDFTHDELVHNPIIESTVDTIQ
                     SVEFERVSFSYNGKDNVINDISFSIKAGERLAIVGENGSGKSTIFKLACGLYDNYEGNI
                     YINGINLRSIQKKSYYKRISALFQDFLKYELTLRENVGLGELSKLYSDEDLISALKYTG
                     VDSIFYFNQEKLNQIDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYLLDEPSS
                     ALDPESETKIFKTFFELSQNKIGIFITHKPSITQSVNKILYLDNGCIAETGSFADLNIK
                     GMKFKNLLDKEIGATYDTSN"
     gene            complement(16119..16259)
                     /locus_tag="EB817_RS05220"
                     /old_locus_tag="EB817_05225"
     CDS             complement(16119..16259)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011528609.1"
                     /locus_tag="EB817_RS05220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05225"
                     /product="lantibiotic streptin"
                     /protein_id="WP_002984803.1"
                     /sec_met_domain="TIGR03731 (E-value: 8e-09, bitscore: 32.1,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNTIKDFDLDLKTNKKDTATPYVGSRYLCTPGSCWKLVCFTTTV
                     K"
     misc_feature    16372..16387
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.51"
                     /tool="antismash"
     gene            complement(16416..17762)
                     /locus_tag="EB817_RS05225"
                     /old_locus_tag="EB817_05230"
     CDS             complement(16416..17762)
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002984805.1"
                     /locus_tag="EB817_RS05225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05230"
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_129304739.1"
                     /transl_table=11
                     /translation="MFKKYSIKNRVWRAVVEIVFGVCITVLMIAIISLSFSKLNIVTSH
                     NVGEEFYIKDKQSIKQLNNYMKTLGLDYVVFDRKTDKAMEGKYLSKEFSLFNEVAEEKN
                     NLTFNSVHYDLYTNINYNIVIRYNEIPEFSNHYLRNVSYNMLTFYILGIGTSISIVVAL
                     TRFVKEISLNFKEIKKLANKMGIEVLSENENYSKIIEFDDILRTLHIKGDNLKSLIERE
                     ILEKQDLTFQIAALSHDIKTPLTVLKGNLELLELTTLNKNQEGYIVSMNNSISVFEGYF
                     NSLISYTRMLSEDRSVKLILVEKLLSELHFEVDDLLNINNIEFSICNRLIITSFYGDEE
                     NLIRALSNLLVNAIRFMPVLDKKIEVILSESGEQIHFEIWNNGERFSDSTLKKGDKLFY
                     TEDYSRGNKHYGIGLAFVKGVAIKHGGNLQLNNPARGGASAIISIKKKI"
     gene            complement(17755..18441)
                     /locus_tag="EB817_RS05230"
                     /old_locus_tag="EB817_05235"
     CDS             complement(17755..18441)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018373772.1"
                     /locus_tag="EB817_RS05230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05235"
                     /product="response regulator transcription factor"
                     /protein_id="WP_002984807.1"
                     /transl_table=11
                     /translation="MYKILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKG
                     YDLILLDIMMPNISGTEFCYKIREEVHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFS
                     LKQFVAKVNSHLKREERAKIKNEAEERVKRSFPPIEIYLEERMLYIDKQPLFLTYREYE
                     ILELLSRHPYKVFTKEEIYEQVYSDEASALFHSISEYIYQIRMKFSSFGINPIKTIRGI
                     GYKWDV"
     gene            complement(18592..20404)
                     /locus_tag="EB817_RS09280"
                     /pseudo=""
     CDS             complement(18592..20404)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001871879.1,RefSeq:WP_014294852.1"
                     /locus_tag="EB817_RS09280"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="SAG1250 family conjugative relaxase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKFLDLFAGIGGFRLGLINQCHECIGFCEVDKFARQSYKAIYETE
                     GEIEFHDIRQVTDQDFRQLRGQVDIICGGFSLVKHFHLQADDWDLRALGELSSLRLLER
                     LIQTKIIFIITS"
     gene            complement(20584..>21204)
                     /locus_tag="EB817_RS09290"
                     /pseudo=""
     CDS             complement(20584..>21204)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017648301.1"
                     /locus_tag="EB817_RS09290"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="replication initiator protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="AIYLIYSNSK"
     gene            21200..21409
                     /locus_tag="EB817_RS09295"
     CDS             21200..21409
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EB817_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164976407.1"
                     /transl_table=11
                     /translation="MAITIWRDDCSFFCIVTSKTQKKGVDNLMSTPENLLKQKSCQRIF
                     GRIFGRKPNQFISFYQSLIALKDW"
     gene            complement(21444..21809)
                     /gene="rplL"
                     /locus_tag="EB817_RS05260"
                     /old_locus_tag="EB817_05265"
     CDS             complement(21444..21809)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplL"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018371186.1"
                     /locus_tag="EB817_RS05260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05265"
                     /product="50S ribosomal protein L7/L12"
                     /protein_id="WP_002984819.1"
                     /transl_table=11
                     /translation="MALNIENIIAEIKEASILELNDLVKAIEEEFGVTAAAPVAAAAAG
                     GAEEAAKDSFDVELTSAGDKKVGVIKAVREITGLGLKEAKGLVDGAPANVKEGVAAAEA
                     EEIKAKLEEAGATITLK"
     gene            complement(21874..22374)
                     /gene="rplJ"
                     /locus_tag="EB817_RS05265"
                     /old_locus_tag="EB817_05270"
     CDS             complement(21874..22374)
                     /GO_component="GO:0015934 - large ribosomal subunit
                     [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rplJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012658294.1"
                     /locus_tag="EB817_RS05265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05270"
                     /product="50S ribosomal protein L10"
                     /protein_id="WP_002984821.1"
                     /transl_table=11
                     /translation="MSEAIIAKKAEQVELIAEKMKAAASIVVVDSRGLTVDQDTVLRRS
                     LRESGVEFKVIKNSILTRAAEKAGLDELKDVFVGPSAVAFSNEDVIAPAKVINDFTKTA
                     DALEIKGGAIEGAVSSKEEIQALATLPNREGMLSMLLSVLQAPVRNVAYAVKAVAENKE
                     GAA"
     misc_feature    complement(22403..22538)
                     /db_xref="RFAM:RF00557"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00557"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="ribosomal protein L10 leader region; Derived by
                     automated computational analysis using gene prediction
                     method: cmsearch."
     gene            22708..24084
                     /gene="mnmE"
                     /locus_tag="EB817_RS05270"
                     /old_locus_tag="EB817_05275"
     CDS             22708..24084
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmE"
                     /gene_functions="other (smcogs) SMCOG1227: ribosome
                     biogenesis GTP-binding protein YsxC"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002888396.1"
                     /locus_tag="EB817_RS05270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EB817_05275"
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis GTPase MnmE"
                     /protein_id="WP_129304743.1"
                     /transl_table=11
                     /translation="MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNL
                     EQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQL
                     LIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLGGSLSQLI
                     NDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILR
                     EGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAG
                     IRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQGSNRIILLNKT
                     DLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISL
                     IEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK
                     "
ORIGIN
        1 taactgacgg acactatcaa acaccatccc gtaatggacc gtatctgtta attggtctga
       61 caaagaagct gcttgcaaat cgactgacaa ttctaaatca accagaaaaa tttgcccaag
      121 ggtctgttct tctttaaagg ctccatggta gccataaaaa cggcaacctt ctaatacgat
      181 tttatccata agtcctcaca tcaactggct caacacagcc acaatgtctt gattagcctt
      241 gacatcgtgt acgcgtacaa tctgacagcc ttttccaagg gcataagcag acaaggctgc
      301 tgtcgctccg tctcgctctt tagctttggt gttgccacct aacaaggcat ctacgacacg
      361 ctttctcgaa ataccaaaca agacaggata acccaactga cagacgcggt ccaatctttt
      421 taataactcc gtattctgtt gaacagattt ggcaaatcca aatcctggat caatccaaat
      481 attgtttttt ggcacgccag catcaagagc tgcttgtgct ctattgccta gaaaatcaca
      541 aacgtcttgt gttacctctt gataaacttc ttcgtcttgg ttatgcatca agatgatagg
      601 cgcatcgtac tcggctgcta aggcaaacat ttgtccgtcg tacaaacctg cccaaacatc
      661 attgagaata tcggcacccg cctctaaagc tgctctagct gtttcggttt tataggtatc
      721 aatgctgatt agaatatcat agttttcttt gatggccttg atcacaggaa ccacccggtc
      781 aatttcatcg gtagcgctta caaattggca acctggacgt gttgattctc caccaacgtc
      841 gatgatttta gccccatcag caatcatttg ctcaacgtga tctaatgctt tttgcacagt
      901 agtgtaagcc cccccatctg aaaaagaatc tggagtcaca tttaaaatcc ccatgatagc
      961 cgcattgccc tcaatcacaa actttccaat tttcataagt tctcctaatc ttttgtcatt
     1021 agagaaataa cttcttgcct ctcagcacga ctttccttat ataagcctct ggcagtggtg
     1081 gtaatggttt tactacctgg ctttttgatg cctcgcatgg tcatgcacat gtgctctgct
     1141 tctaccataa ctaaagtccc tttaggattg agggcttcaa ctaaagcatc cgctatttga
     1201 gaggtcaaac gctcttggag ttgaggtcgt ttactagcta cttcaactgc tcgcgctaat
     1261 ttactcaaac ctgttactcg accatcactt ggtaagtaag cgatatgagc cttgccataa
     1321 aaaggaacta agtggtgctc acatatagaa taaaaactaa tgtctttgac aatcaccaca
     1381 tcctcatgtt gttctttaaa gacagccgta aactcctctt taggatcttt tcccagtccc
     1441 aaaaacatct ccgcatacat tttagcaacc cgtttaggcg tgtcaagaag accttcccgt
     1501 tttggatttt caccaatagc ctctaaaaac tgataaatgg ctgcttctgc tttttcctta
     1561 ttaatagaca ttagtctttc ccttttcatt agttttttcc ttttcctttt cattttctct
     1621 tttttaatgg gttaaaagaa cgcttttttc aatatgtttt ttccaatact gtctaatttc
     1681 tgaaataaaa tatagcgacc ctgtaatcac gaaaaagtca tctgctttag catgcttacg
     1741 cagggccaag aaatctttga aatcagcaac cctaccaaaa cgttctgggt atttttccaa
     1801 tggataggcg ttagggtaat gaaagctagt aacctgcaag tcacctattt gctcaagagc
     1861 aaccaacata tctgcaatag gcttggtgtc gatcgcacca aacaaaatat gaagcttttt
     1921 atcattgtag ttatttttta agacggctac caaagcagca acgctttcat tgttatgagc
     1981 cccatcaatc attagatttg gtgctaataa ttcggtacgg cctagccaca aactatttgc
     2041 cagaccttcc cttatatgat ctggagttag cctaggatag cggtctttca aggttaagca
     2101 agtcataata gctaaagctg cattagacac ttggtggtgt cctggcatag cgatgtgaat
     2161 atctgaaata actcctaaag gactagtaaa acgatagcca gatgcgttct cagccatttg
     2221 aaactgctct tgccattccc agattgaagc accaacctgc tcagcttttg ttaaaaaaac
     2281 ctctcgagct gacgggtttt caacggcaaa aacaagggtc tcgccccctt ctaaaacacc
     2341 agctttttgg gcggcaatat cagcgtaagt ctctcccaaa atagcttggt gatctaaacc
     2401 aattgaggga cagaccacaa ccattgcttg aaaaacattg gtcgaatcat aaagaccgcc
     2461 aaggcctgct tcaataatag caatatctac aggatgcata tcaccaaaat agaggaacat
     2521 gatcaaagta atcacttcaa attcagttac ctctccaaaa tcagtctctt gaactagacg
     2581 ctctgtcaaa ggacgaatac gattagcagc aataaccaaa tctttttctg aaatcattcg
     2641 accatttatg ctaatacgtt ctttgaaatc cataatgtaa ggagaggtaa aggtccccac
     2701 ttcataacca gctgtcgtaa agatatgttg taaatgattg accgtggaac cttttccgtt
     2761 agttccaacg atatgcactc ccttgacatt tttctgggga tttcctaact gtccaagaac
     2821 ccaaagcata cgttttaagc ctggcttgat gccgaaaact aagtgatcat gaatccattc
     2881 tagagtctct tcataagtca tttcatacct cacatctatc tttagtatac catatataaa
     2941 aaaaagtgac agcagataac ctagagtagt accctttttt ttattatcct caccaaacac
     3001 tcaaataagt tctaaagtac actacacttt tatcttcatt gcttttttta cgtgataaga
     3061 ataccagccc cacatagtct ttgctacctc ctaaagtgtt atctgtgaca acaatttttt
     3121 tactccttaa tacacgttct tccaaaaaac aagaaaaaag gctgacttca agccttcttt
     3181 tctctaaaaa atgttacaat agaggtactt atatcaaaaa aaggagcaag taatgaacaa
     3241 tagacataaa cggcgccaaa aaagaaaagc cttcactctc attaacctta tactattatt
     3301 tgcctgcatt cttggtttga ccctcatttt ctatttatat caagggtcta acaaattcgg
     3361 cttgtcagat gtctctcaat ttgtacctaa aataagtctt tttcatcaca aaaagacggc
     3421 aaaaaaagaa acgacaaaac ttaagaagac tcatttcaat tcctcaaaat ctcaaaaaaa
     3481 ggcccattct aaattaactt ggaccaagca agaaacacct gtcaagatcc caattttaat
     3541 gtatcatgct attcatgtaa tgtcccctga agagacggcc aatgctaatt tgattgtcaa
     3601 cccagatctc tttgatcaac aacttcaaaa aatgaaagac gagggctact attttttgag
     3661 tccggaagag gtctaccgcg ctctttcaaa taatgaattg cctgctaaaa aagttgtatg
     3721 gctaacattt gatgacagta tgattgattt ctacaacgtt gcttacccaa tcttaaaaaa
     3781 atatgatgct aaagccacca ataatgttat tacaggacta accgaaatgg gaagcgctgc
     3841 caatctgact cttaagcaga tgaaagaaat gaaacaattc ggtatgtctt tccaagatca
     3901 tacagtgaat catcctgatc tagagcaggc tagtcctgat gttcaaacaa ctgaaatgaa
     3961 agattcaaag gactatcttg ataagcaatt aaaccaaaac actattgcca ttgcttatcc
     4021 atctggtaga tataatgaca ctaccttaca aattgcagct agacttaact ataaattagg
     4081 tgttaccact aacgaaggaa tagctagcgc ggctaatgga cttctttctc ttaaccggat
     4141 tcgtatcctc ccaaacatga gtccggaaaa tcttttacaa acaatggaac cataacatca
     4201 atttttttat cattctaaat catactcact gtaatcaaaa aagacagtta tgaaaaaatt
     4261 ctttcataac tgtctttttt gattgtttta aaattatttt attcttatct ttaacgtctt
     4321 ttttcaagaa aatctcgcca ccacagctgt aagtcagagg cttttttaag agattggcta
     4381 gctttaagag gaatacgctt aggttccttt aaatacctca ctgactgatc tgttattctt
     4441 ggagacgtca aataagcaac cacttcacct ttagtaatcg gtgctagtaa agaagtctct
     4501 gatatcataa attgtttagg tttgggaact tgttcaccct gttgcaaaat gatggttaca
     4561 tctccggcaa cggataccgg tagttctttt acttggccat cttgaatagg gagcgaccgc
     4621 tccgagacaa gacttccttt tttaagaatc ttacgacgac aataagttct agccacatag
     4681 tccaacaaac gatttgcttg ctcaaaccgc gtgttttggt ttttatcaga tccatcggca
     4741 tttagaataa cggtaatcac tcgcatacca ttttcaatag aagttaccac aagacaatga
     4801 cctgccaagt ctgttgtccc agtctttaaa ccatccactc ctgctctacc cttagccata
     4861 cctggtaaga gttgattaaa acttttaata gaattgccag caaaattaac ttctgtttgt
     4921 ttggtgatct ctaaaatctc aggaaaatct tctaacaaat gcatcgtcac aactgcaaca
     4981 tcttgagcac tcaaggtatt ttcttcttcc aacgcagaac caggataacg attatccttt
     5041 aacacctcat ttggcagacc tgaggcgttg aggattttac caaaagtaat cccccaatga
     5101 gatagctgtt ctctcatttg atttacaaaa tgaggctctg agcccgccac tttttcggcc
     5161 aacgcaatag cagcgctatt tgagcttgct accaaagtag ctgtcaacag gtcttgaact
     5221 gaataagttt ttttgtcaaa aggtacatta cttaaagacc tatcttttgt taactcgaag
     5281 gcataatctg agagattaac ttgatctgat aattgcagct ggcctgattt aaccttatct
     5341 aaaaccagat aagccgtcac caatttggtc aaagaggcaa tagcatctgg cgtcttagcg
     5401 tctttctcat acagaactct cccagagtct gcctctacga caatcgcatg ttctgctccc
     5461 acttgaaaat cagctgcgag aactgtttta ccaaaccctg aacaagttaa taccataaaa
     5521 aaaaggataa cccacctttt tatcattata tctttcatag ttactattat aacaaaaatt
     5581 ctcagaaatt tggaaggaag tatagtggca cacaccttta gtagcttaaa caagctcata
     5641 aagcaagtac cctgtgacaa taacacatcc tgttatatgg gcgatataat aagcttcgtt
     5701 atatcaatta gttgtttggc aggaattttg gtataaaatg gaatctaatc ctgaacttat
     5761 tacattttgg gttatttctt cagatactgt tttatctaat gcattaaacc agtgactata
     5821 tgtattcaaa gttgtagact tatcagcatg tcccatacac tttgcaacgt acagaatgtc
     5881 ttttttcaaa acattaataa gataggaagc atgactatgt cgcaagactt ttcccgttat
     5941 cactggtact cctacttctt gagctttgtg cttaataact cgacaaatcg ttgatttaca
     6001 aaatggttca ccaaaccgtg aaataatgaa atctgtgtca gtattgacta cttgatttct
     6061 tctccaattt tccaatacta ctattgtcac atcatctaac tcaataagac gttctcctgc
     6121 tggcgttttt gtttgatctt tacgatacca atttccattt tcatcctttt ccaaggttgt
     6181 atgaactttc aaaaattttt gttcgaaatc gatatcttcc catcataatg ataaaccttc
     6241 acttacacga acacctgtca tataatatag ccaaatagtt gtaaatcttt gtagctcttc
     6301 ataatcttgc aaatcaaacg attttataaa attctgaaac tcaatataag tccaaaatgg
     6361 agtatcggga tgtttccctt taggattatc caaagcctta cacggcactt ttgaaatata
     6421 gtctaacctt tcagcatacc ccatgcaagc tttgaatcgc gaccataaat tctttgcata
     6481 attttcaata atatgtaaac taaaagattc acaatctcaa gctgttattc cctttaaaag
     6541 tttagaacca aaatactgaa taaataactt atgatgtggt aaggctattt cataagttac
     6601 agtctgaacc ttttgcttat atgctcttag gtaaatagta ttcatatagt tttcaaacga
     6661 tatattgtca ttttcaatac taagattatt actaaaccca tacctaatcc gaaccagttc
     6721 atcatacgct tctttcattg taccaaatgg ctctccatac taattctttc tggctttctt
     6781 ttgaactcgt ttacctgtta ctggatctac accaagatca gcttgataaa atatcttacc
     6841 attcttatca caataaacac ctttgtactt tttttgattt tttatagtca tctttaattc
     6901 tcactttcta aactttcttc agagagtaga atacctatta actcttctac aatatcttta
     6961 ggagcaatac caagtcttct attgtcaaag ggcgatttac ttaattgtac cgcattttgg
     7021 tcaatttcgc gagcttcttc aaactttttt atagctattc tttttgcttc tctaataata
     7081 tctcttgcag tatgttcgag aaaaccaata ttcatcaagc tttttatatg ttactatttt
     7141 cacacctcca ctcctttcaa aaaaattgca acctccgtgg gtatgactgg ttaaatcact
     7201 catgggaatc tcacccactg gccttttacg ctggcagcct gaacgttcag aagtatcatt
     7261 gtccctattt gtggtcatgg cagatagaga accactctat tttatagcta ataattatcg
     7321 ctcctatcac ggcgtatctc actaaattgc tcgacaaaca agaaagtccc acctcggttt
     7381 attcagttgt caatgaacaa atcaaggcga gacttttatt tattatgaaa acgatacgga
     7441 taatctgttt gccctaataa ataatcaata ctgacgttat agagtttaga aaactgcaca
     7501 agaacatctg ccattaaggc aacctctcct ctctcaattt ttgcataatt tgcatgagag
     7561 aaggaaagta aatttgcaac aaacttttga gtgaaatcgt tatcttctct caaattccta
     7621 atacgcggat acatctaaca ttctcctaat atcagtataa aggagatttg attaaaaaat
     7681 gtttaattgt cctatttgga caagactatt aaatataagc tagtaatcca ttgaaatttt
     7741 atagtcattt tttagttaaa caagttagat agtatttata acttaaaaaa tcatatttat
     7801 tgctaggtaa acaaaataga tgtatttaac tacttgtcaa acagtcttga ttccaacttt
     7861 taaatattcg tatatgaagt aaagctactg tgcatgaaac aaaaaatata acaataagtg
     7921 gaacaattgc cattttctgt tggttatata gagtatctga tattcttaaa agccatgccc
     7981 atggaataag aaaccatacc ttatcaccaa ggctcgtttc acaaaatgct gcagcaataa
     8041 cacctaccat tgaaatacct aatgccacac ctgtactaaa tatatagcta ataatatgat
     8101 tgatcagata ggttacatag gcaaaaatga tataaattaa actattcaaa ataagtagtc
     8161 tgagagatac atttatacca atagttttca ataaaagaat aaatatagta attgaaataa
     8221 ttaatactat acaatagcat aaccatagaa atactaattc tacaataaat ggcttataat
     8281 tcgactgtga gtaacccaat aaatatttat attttccaga tgattcttct aaatttttta
     8341 attgaatgca cacaatactt gcaacaaaag gaagaagtac acctactatt tgaaagtagg
     8401 agaataatac agtcctgctt tgtaaacctc cacgttgact ccaatagaaa aatagaagta
     8461 agggaaataa tagtgcagct aaaatatgta ttagtaaata tgaagtattt ttgattttta
     8521 aaaaattaga acataaatat gatttcatga ctatttcacc tgttttttga aagagatagc
     8581 aaatagattg gtcagtaaga tgaaaaaagc aattcctagg aacaatgata taaaaatctg
     8641 tgagtagtct ggaacaaact ccgctccaaa aggtatacta tttattctca ttcttgtcat
     8701 tggctcaagc aacttcaacg accaatcata agggaacaaa taccatttat ttaagagaga
     8761 aaaacttgta ccaataatta gtggagatat aatattaata atcatagcaa aatacacatt
     8821 aatttttctt gatagccata aaataaacgg gatttgccat agtgtagtca accaaattaa
     8881 caagatagtt aatagtatcc tacctatact aataagactt ggagtaggta ggacaaaact
     8941 aattacaata agcattaagc ttaaaatcat actaattatt agatttataa gagctatcaa
     9001 tagaactctg gcatattcta ccttttttaa atcaacatcc cttgataaaa aaacagaata
     9061 cttattagaa tctaattcta atttatttaa caaaccagaa tttacagcaa taataacatt
     9121 aatccaaata actccccact gatttactgt tgtttccgca gttaaacgta ggatattttc
     9181 accacctaat gctgaaaaca ataaagataa catcacacaa ataataggga aaataagaat
     9241 caacttgcta atactcgtat tttttatttt taataaattt gataaaaaaa tttgtaccat
     9301 agcccctacc tcctcttttc aaataaaatt tgattattga ataactcttc aagattctca
     9361 gagccgtcat attctttttc cagaataatc tttccttcat agataaatcc aataaaatca
     9421 gctagatgtt caacttctga cagtatatgg cttgaaatca taattgtcat tccttctgat
     9481 ttaaatgact ctataatttc ccttaattct tgaattccaa ttgggtccaa gccattagta
     9541 ggttcgtcta atataagtag tttaggtgaa tttattaaag agatagctat acctaaccgt
     9601 tgcttcattc caagagaaaa ttgttttact ggtctcttgt caatatttcc tagaccaact
     9661 ttatttaata atggaagtat agtgctttct gaaacaccaa gcattgttgt aactaccttc
     9721 atattatcgt aagcactcaa atttttataa agtggtggtt cttcaataat actcccgatt
     9781 tttcgcagat cccgacgtga ccattctcta ccttcaaaaa taatagaacc acttgtctta
     9841 ctaactaagc ctgtcaaaat tttcataata gttgattttc cagcaccatt tggaccgatt
     9901 aaagcataca cttttccctt agaaatattc atattgacat tattcaatat ggttctctta
     9961 ccataagatt tttttagatt ttgtattttc aacatattag ttactcccat tctatatatt
    10021 gctgagcgtt tagtgtatag taagcaaaac aatacacttt ctcttcaaac tctctatcaa
    10081 tcccgtttaa tcgattcatt gatagatgta aaaaacttcc tactaaattg aatttagtat
    10141 tatagatatc atttgtacca ccaaatcgat tatactcttt catataagac atgagatatc
    10201 tatccatttc ttggaaaaaa tcatatctat caagagctga ggtgactcca ttcaaaatct
    10261 tcatatactc aataggtaaa tcaattggca aatttttgaa atctttctta tactttccgg
    10321 tataattctc aaataagaaa gagcgccttg tttctttatc tttgaaaaag tgatttagat
    10381 aatatagaac caagtaagta gcacaaacta atctttcatc atctgaaaat tctattgtat
    10441 tattaagaaa taagatagat tctttacaaa aaatttcctc tgcataactt attaaatgag
    10501 gtcctccata tctatttact tctggtttat agctactcac ttctatgtca gagataatac
    10561 aactctcaat cagttgaggt aataaatctt gaactactga caaataaaaa gaaaagttat
    10621 tttcaatcga atcacaattt atccgaattc ttatatgatc attggtatca ttatatctca
    10681 tataaaacat gttactttgg ctaaacagtt ctgatggcag gtttagccaa aattttttcc
    10741 agttatttag taattcttct tgtcgctctt ttggaccata aaatttgaaa aatagccagt
    10801 cacaaaatgg taaatatatt ttcttaactt catttttaaa ttgaacatta tcgtttgtat
    10861 tgtttattcc attagattcc ttaagaattg gaactactat ctctgtattg tagttcccta
    10921 aattatcctt aaaaatagac tctccctgct caattcctct caaagaaaca aacctatatt
    10981 tattaatgtt tttaaataaa atctctaaat cactgtctat agataaatct aacctcaatt
    11041 cattatctgc atatttcaaa ataatatctt taggtatctt ataagtcttt ctaaacttat
    11101 tgaatatatc ttttttacca gtaaatattt tttgatgtat aatctcttct ctaattactg
    11161 ataaattcca ctgagcagtg gcaatcgtaa tgtcttcaaa taaaatttca ggaatatata
    11221 ctctttcctg agccaaaata tcccaaggaa ataatgacca atgcgataaa ccgtactcaa
    11281 actcagataa atcaaccaac aatctcaaaa ccctgctttg gctatcggaa tttagcatat
    11341 tattcatggt aaatttcaac tcatttttcc catcgatagt tgtaaaatga aacttaccat
    11401 cactatatct tatataaata tcctccaatc gcagttcgtt ctctgaatcc catgatgtgg
    11461 taaaaaatga agtattataa gactcatcac tataattttg aattacattc gcaagtctta
    11521 tctgtttagg aacaaatgac aactctacat tcgtattatt ttgatggttt aaattcttaa
    11581 ttgtttctct tactgtttcg cttaatccat agaatcttcc aaagcttcta cctgcttgtc
    11641 cagaaccgat attagctcct aaatataact tcacatcatt atttattatt tttatattaa
    11701 aatttaattc aaacgaatct aaactattgc tttgatctgt ttgaaaatca tctaaatctt
    11761 ttgaataaaa ttcgatatgc cctccattta atagagcttc ctcatatttc ttttcaaaca
    11821 tttgcattat tggatcgctt aactctattg cttcaccttc tcctcctttg taatattcag
    11881 gaaaacctat gcctgcatct ttatttatta cttcaacaaa gggaattgag cagttttctc
    11941 catatttgcc aataaatttc aactgatact cttcaagtga atttttcctc ccccctcttc
    12001 tctttacatt tgtatttaat tttacaaaca tctctgcgag tcgttctata ctttcccgag
    12061 ccgtttcaga tagaatatta aaaccgcctt catactctgc taatgaatca acttttaagt
    12121 aatttccacc gttatcatat ttataaatac tttccatttt atcaaaaatc tgcaaaagta
    12181 agtctctacc ttccccaata tttaaatcgt tgtaatcttc aatcatcttc tttaaagtag
    12241 ttaagtcagt acatagtgtt ccttcttcta atttagatag tagataatct aaggaattga
    12301 tattacaaat tggtggtctt aaatctgaaa ttaaaaaatc atttgtaact aagtcgtgta
    12361 tatatgactc tagcatgtct gacactatat ctggataatt atttttaaat acatctatta
    12421 actcttcata ttttatatat cgagttttac atttttctac aagtaactta attggttttg
    12481 aaaaacttat gtttctatct tcctctgatt cattcactgt aaatggtagt acatatctgt
    12541 caccttgagt aaacgccgct gtatttattt ttaatgaaag tttttcaagg ttacttattt
    12601 catacgattt tactagagaa tatatccatg aataatctgg gactgctttt ttaataaaac
    12661 taaccttttg tacattagaa gtggttccct ttgtcaaatc aactgtatta atagcagtaa
    12721 agataccaaa tggagtagtt ctaaacgctg ctcttttaga ataactattt aatgagactt
    12781 ttacattttg ctttttcttt tcattacatt tatcaaaatc tattacacta tcataaagac
    12841 tgggactagc aactaaaagt tgttccataa aaactttatc atttattaaa tcttcatagt
    12901 ctttattata aaattcttgt ttttgcaatg gaatacgaat cataccagtt ggaaatacct
    12961 tatacatttt gttctccttt tcaaattaaa taaatattct ttgccacaat agctcctcgt
    13021 cactgtaagg atttaataag aataacacta tccctgatac cccttgcaat atccctattg
    13081 actccagttc aacttctatt tctccaaatt tttctctgtc agtataccca aatacttttg
    13141 tagttgaaaa cgatgtaatt atttgttggc gaagctcttc tgcaaagcga gttagcctct
    13201 cacttgaata atttttacca atcaagtcat atataaaagt tactcctgcc aaaccatggc
    13261 acattgtaag agaatagaca tttttgtctg aacttctcat ctgagcaatt aaactttcat
    13321 taatatcgtc aataaaattt aaatctatca attgacacat tttaaaaagg gcaactgcag
    13381 ttccaggcgt accgaaacac catgccattc tagtaggaag ataatttaaa tcaagatcca
    13441 aaatattact agtataaatt tttccaggcc atagtttgtc atcccttcta aataaaaaca
    13501 ttaaatttat agctttattc agtatatctc ctacttctac actcaaaatt ttttctgatt
    13561 ttaattttgc taggattagc ataggaccag taattccatg tgcaattcct agatcaaatt
    13621 cagcttctct atcttcagaa caattagtta ccttatttaa aattgtctca atatatttca
    13681 aaagataatt tccaatttga tttaactcta cagaaaaaaa ttcttgttca aggagtaagt
    13741 aattagttat tccactaaat ccgttaacca tatcataatc atatggctca ataattcctt
    13801 tctcaatatt agaaaaactt actaccaatt tgtctttaat ttgttctttt agaagacaat
    13861 ttaaggatga taataatttc ggataatact ttccagatat actcgcttct ttaatagcta
    13921 atgcaatacc tgcagtgcca gcatagagag acggagattc tataccatct ctagagatta
    13981 tgtctactaa tttctcaacg tatatgttgg agaatgttag atatctctca tcttttgtca
    14041 ctttatatag tgaactatac attaagatta atgatggcac accatgactc agagatttat
    14101 caaaaaaggt atttctatat ttagattcaa tattaattag tactttattc tcactttcag
    14161 ctactatctg ttcataattt ataaaactat ctgcaatgta atctactatc tgtttaattt
    14221 gaggtgtcat atgtggctcc aatttcttta tctaataagt ttttaaactt cattccttta
    14281 atatttaaat cagcgaaact tcctgtttca gctatacatc cattatctag atacaaaatt
    14341 ttattcacag attgagtaat gcttggctta tgcgtaataa aaataccaat tttattttgc
    14401 gataattcaa aaaatgtttt aaaaattttt gtttcagact caggatctaa cgcagaacta
    14461 ggctcatcta gcaaatagca atccgcttct ttgagatata ctcttgataa tgcaattttt
    14521 tgccactgtc caccagataa ctgtctccca tcctcaaacc aattccctaa ttgctgttcc
    14581 agatctatct gatttaattt ttcctgatta aagtaaaata tcgaatcaac tcctgtatac
    14641 ttcagtgcac ttattaaatc ctcatcacta tataactttg ataattcacc caatccaaca
    14701 ttttcacgca gtgtcaattc atactttaaa aaatcttgga acaatgcgga tattctcttg
    14761 tagtatgact ttttctgtat tgaacgaaga ttaataccat ttatatatat attgccttca
    14821 taattatcgt aaagaccgca ggctaatttg aaaatcgtac tttttccaga accattttca
    14881 ccaacaattg ctaacctctc tcctgcttta attgaaaaac ttatatcgtt tattacatta
    14941 tccttaccat tatatgaaaa agaaactctt tcaaattcaa ctgactgaat tgtatcaacc
    15001 gtactttcga ttatagggtt atgtactaac tcatcatgcg taaaatcata caataactcc
    15061 atgtacaatg aaccattata gaaagaatag atattattta ctatattttg tgtacttgtt
    15121 tgcattgtag ataaagacct tataaaagta gttacatttc caactaataa tattcctaga
    15181 aatgcttctc taactgcaag gaacataata atagattgta tagcaatctc caatacacct
    15241 aatactatgc cgtatttcat tttagatcta tttatactat tttcctgatt aataaataat
    15301 tgattatttt tatcatattt ttttagaaaa taactttcta acgtacctaa cctcaactcc
    15361 ttgacagcaa aatcatgtgt taaaagatga ctaatatacc aatttgctct ctcatcgcta
    15421 ctccttttat atagtatctc aaattcattt ttaccaattt tcaagtagat atatatagaa
    15481 acgataggaa ggataagtaa aagtggaaaa attgatatct tccaatttaa taaaataaca
    15541 aatgaggaaa ttaatgatac taacgaagat aatacagaaa taattgactt atatatttga
    15601 aaaggtttat aagatatttg attttgtatg cgagtgatat catcatagat ttctggtgtc
    15661 tcaaattcag ccaatgttaa ctttacagtt ttctgcataa ctaaatggtt catcttatag
    15721 tgaagaagta tctgtaattt ggtatcaata taactatcaa cttctcctat tataattgtc
    15781 aataatgtta aagcaatata tgagataaaa gcaatcatca atgtgtgaaa attttttata
    15841 tcagtcgtta taatgtttaa cattttttga actagtagca tactaaaaat gggtaaaatc
    15901 ccttgaaata agctaatagc aattgagaac accagtaggg agaaaccagc ctcttttacg
    15961 agatgaattg tttttattag attctttagc tgagctttaa tcatgtataa cttccttatc
    16021 tactaataaa ggagcaaact aaaatcagtc tactccccta aatttataaa tatatcaaat
    16081 tatttgaaat tataatgttg atgataatga taactttatt atttaacagt tgttgtaaag
    16141 caaactaatt tccaacaaga accaggggta cataggtaac ggctaccaac ataaggtgta
    16201 gcagtgtctt ttttatttgt tttcaaatcg agatcaaagt ctttaattgt gttattcatt
    16261 ttctagttcc tctcttacgt ttttgcatcc gatatattta catgattatt atgacacccc
    16321 aagttcagaa tttgttcaga aaaaaagtat tttagccaaa aatcacaaaa atttacgatt
    16381 ttttgcctga aatactccag tttcaatcaa atctattaaa ttttcttttt tatcgagatt
    16441 atggcgctag cacctcctct agctggatta ttcaattgaa gattcccacc gtgtttgata
    16501 gcaacgcctt taacaaatgc caaaccgatt ccataatgtt tgttacctct gctataatct
    16561 tccgtgtaaa ataatttatc tccctttttc agtgtactat cactgaaacg ctcaccatta
    16621 ttccatattt caaaatgaat ttgctctcct gactcagaca gtataacttc gattttttta
    16681 tctaatacgg gcataaatct tattgcatta actaaaaggt tagaaagagc tcttatcaga
    16741 ttttcctcat ctccataaaa agaagtgata ataagtctat tacaaataga aaattcaata
    16801 ttattgatat tcaataagtc atcgacttca aaatgtaact cacttaatag cttctcaact
    16861 aaaattagtt tcactgatct atcctctgaa agcatgcgtg tataagatat taaagaattg
    16921 aaatagcctt caaaaacaga aatactattg ttcatagata caatataacc ttcctgattt
    16981 ttatttaaag tagtcaattc taataactca agatttcctt tcaaaaccgt taaaggtgtt
    17041 tttatatcat gcgaaagtgc tgcaatttga aaggttagat cttgcttttc caatatttct
    17101 cgctcaatca aacttttcaa attatcacct ttaatatgta aagttctaag tatatcatca
    17161 aactcgatta ttttagaata attttcattt tcagaaagga cttctatccc cattttattt
    17221 gctaacttct tgatttcctt gaaattcaaa gaaatttctt ttacaaaccg tgttaaagca
    17281 actacaatgc tgatactcgt tcctattccc agaatataaa atgtcaacat gttatatgaa
    17341 acatttctaa ggtaatggtt agaaaactcc ggtatctcat tatatcttat aacaatatta
    17401 taattgatat tagtatataa atcataatgt acagaattaa aagtcagatt atttttttct
    17461 tctgcaactt cgttaaataa agaaaattct ttagataaat attttccttc catagcttta
    17521 tctgtttttc tatcaaaaac aacataatct aatcccaatg tcttcatata attgttcaac
    17581 tgtttgattg actgtttatc tttaatataa aattcttctc ccacattatg agatgtcact
    17641 atatttaact ttgaaaaaga aagcgatatt atcgcaatca ttaaaacagt gatacaaact
    17701 ccaaagacaa tttcaacgac ggcgcgccaa acacgatttt ttattgaata ttttttaaac
    17761 atcccattta taaccaatcc cgcgaatagt ttttattgga ttaattccaa aacttgaaaa
    17821 tttcattcta atctgataga tatattctga aatagaatga aacaatgctg aagcttcatc
    17881 gctatatact tgttcatata tctcttcttt tgtgaaaact ttatacggat gacgtgacag
    17941 taattctaaa atttcgtact ctctataagt caggaataac ggctgtttat caatatataa
    18001 catacgttcc tctagataga tttctatagg tggaaaactg cgcttcactc tctcctcagc
    18061 ctcattcttt atctttgctc tctcttctct cttcaaatga gagttaactt tagctacgaa
    18121 ttgttttaag ctaaatggtt tcacaataaa atcgtctccc cctatattta aagcttggac
    18181 aatttcatta tcgccatcta aagcgctaac aaaaataatt ggagaatgaa cttcttcccg
    18241 aattttataa caaaactcag ttccacttat attaggcatc atgatatcca ataagatcaa
    18301 atcatatcct ttaaaatcat caaaaactat tggtaattct atctcttgac aggttataac
    18361 atggtaattt tcaatctcca aagcagtctt cataagcttc agaatttctt tatcatcatc
    18421 tatggctaaa atcttataca ttattacccc ttttaaataa tgaaatactt acaaataaac
    18481 tattctcaat gtaagcggca ggaatcattt ctttaatata gttatttacg aaacatcaac
    18541 tagattttaa tatctgatat aaaaattgct accacccaaa ttatatcata attactccca
    18601 ttgtatttca tttcgagaag tatcgataat tttgctatca ctcaagatct ctccaaactt
    18661 ttccaacctt cttactagat attcatactc atctatggat atattaagtt cattttgaga
    18721 agtttcaatc tctttctcaa cttcttctat ttttatagct gcagtcaagt tcatcttggc
    18781 atagtcatat ctggccaaac ggcggttctc tatatcgttg ttgttcatat taagcaagac
    18841 ctccgcaacc ttattgagat gagcaatatg gtcctgcaac tctgtaatgg tcaaatctaa
    18901 ttgagccata tctttaacaa tgtcatcttt aatatcttga taaggcttat tctccgtatc
    18961 taactcaatg aggagactta tttcttcaat ctttttctta agtgtatcaa tggttttggt
    19021 cgtcttcttt ttggaatact cttgctatca ttggttaact ggtaaatgag ctcacgccct
    19081 cgcacatagc gattaagttt agacgcctcc ttgttgtaaa tgaagaattg tgcggtctca
    19141 cgaatataga ctttatattt tttatgattt tcttctttcc taatatccaa ttgatagtta
    19201 ggaatgaaaa taagaccact ctgctttaca ccaaaagaca ccttgatata aatgtcctca
    19261 gcaattaacc tctcaatttg atgttccaca agttcaactt caaactcatg gatggcatct
    19321 cgttgcccct tgtatttctt gaagacttcc ttactctctt cagtggatac ctcctcttta
    19381 tctcattctt cttgaaaagc atgtactgtt tctgtagact ttctaatcga tctgaaacac
    19441 cgacttcctt atttttaaag taatcttgaa aaaattgaca tcatataatt tcttatcgct
    19501 tattttttta tgacctaaac ttatcttttg agtatcttct tctaggataa aagttacatt
    19561 ttttgtttta agtcaatggt tagattcact tcttttgctt ttaatagtag ctcctctaat
    19621 gaattggcac ggttaaacaa aaattttaat cgactttcaa tttctatctt ggcaaaatgt
    19681 gtacgaaaaa attcttcatc atataaatct cgtttactga gttgacgacc tcgaattggt
    19741 tttttcatta ctcgatccgt catcatgaat ctgctatgct tctgactaaa atcaatatga
    19801 acatgtaatt actctgcttt ttctaaaaaa tcatcaaaga actttgactg ctgcatcaaa
    19861 aaataaagac gttgctttag ttcaaactta tggctagtcg ctctatattt ttgatagtca
    19921 cggtaagaga aatgcttttc aataattttc gccccagcca ttttagaaat gcggtctgaa
    19981 atcatacgaa ggtttcgttc caaggcataa ttccatatca actttttatc tgaattacag
    20041 tcaatggcgt tgattaagat gtgattatga atatgatctt tgtctgtatg agtcgctcga
    20101 gtaatctcaa agaagagagt tctcctagtg ccctcaaatc ccagtcgtct gcctgcaagt
    20161 gaaaatgctt gacaagggaa aaaccaccgc agatgatatc cacttgccct ctaagttgtc
    20221 taaagtcttg gtctgtgact tgtctaatgt catgaaattc tatttctcct tcggtctcat
    20281 agatggcttt gtaagattgc ctcgcaaact tatcaacctc acaaaagcca atacactcat
    20341 ggcactgatt aattaaaccc aatcgaaagc ctccaattcc tgcaaacaaa tctaaaaact
    20401 tcatatctct cattcctttc tgacaaaata aaaggacctt actgcttatg taacgtcctt
    20461 actcaactat aatcttccat ttctggtgca gtgataactt caataatcaa ccaaattgtc
    20521 cttagatccc aaacacctaa taatagccac caaaacatct tactcacctc acttcgcttc
    20581 ttgtcacctt agttgcttgg tccattcgga taagacacca ttaaagacat attccgcaat
    20641 agcttcagct gttcttgcga accgtatgtg ttccagcgca taagcatagc gttcttcaaa
    20701 atagctcatg actaagtcac tagcagcttg tgataaacca ccttcacgta attgggaatg
    20761 aaccaaactc caaatataat ctttgtcata tttggtgacc tgatcaactt gacgggtaaa
    20821 gtgaccctca gtctttttca cactagtgca ctcctttctt tcctcctcgt cctcaatgac
    20881 taaattactc tctttagttt cactaccttc agtttcactc ttttcagtct cactaggggc
    20941 tgaatttaac acggggcttg tctgtttttg agactggtcc cgtgtttttt tagactaccc
    21001 ccgtctgaac ttaagactgg ggtggaatca tgttccaact ttcctaaata aatcttatta
    21061 gccaaacgcc ctttttcact gggagactgc tggccttcat cgatcaaacc atagtctcgt
    21121 aggttttctt aatcactaac aatttcgact tggaacagcc aaggagtact atcattttga
    21181 gttggaataa atgagataga tggcaatcac catttggcgt gatgattgtt ccttcttttg
    21241 catagttacc tccaaaacgc aaaaaaaagg ggtagacaat ttaatgtcta cccccgaaaa
    21301 tttattaaaa caaaaatcct gccaaagaat ttttggcagg atttttggca ggaaaccaaa
    21361 tcaatttatc agtttctatc aatcgcttat cgctctcaaa gactggtaaa tagggattcc
    21421 gcaatctaat tatgatgtga ctcttattta agagtgattg ttgctccagc ttcttcaagt
    21481 ttagctttga tttcttcagc ttctgcagca gcaacgcctt ctttaacgtt agcaggtgct
    21541 ccatcaacaa gacctttagc ttctttaaga ccaagacctg tgatttcacg aacagctttg
    21601 ataacgccaa cttttttgtc gccagcagat gtcaattcaa cgtcgaatga atctttagca
    21661 gcttcttcag caccaccagc agctgcagca gctacaggag cagctgcagt tacaccaaat
    21721 tcttcttcga tagcttttac aagatcgtta agctcaagga ttgaagcttc tttaatttca
    21781 gcaataatgt tttcaatgtt caatgccatt gtgatttcct ccaaataatt aatttaaaat
    21841 gttaagcgta gccttaagct actctgagac gtcttaagca gcgccttctt tgttttctgc
    21901 aacagctttg acagcgtatg caacgttgcg gactggagct tgaagtacag aaagaagcat
    21961 agaaagcatt ccttcgcggt ttggcaatgt tgcaagtgct tggatttctt cttttgaaga
    22021 aacagcgcct tcgattgcac cacctttgat ttcaagtgcg tcagcagttt tagtaaagtc
    22081 gttgataact ttagctggtg cgataacatc ttcgttagaa aatgctactg cagatggtcc
    22141 tacgaataca tctttcaact catcaagacc tgctttttca gctgcacgag tcaaaattga
    22201 gtttttgata actttgaact caacgccact ttcacgaagt gaacgacgaa gaacagtatc
    22261 ttgatcaact gtaagaccac gtgaatcaac aacaacgata cttgctgctg ctttcatttt
    22321 ctcagcgata agttcgactt gttcagcttt tttagcaata attgcttcac tcattagttt
    22381 tacctccgtt tttatttttg ggctaggtac aaaaaaatcg cacctaaacc tagacacgaa
    22441 agtacaaata cgttattttc tttaatcacg ttttgtgcct cggcaggaat attatgagca
    22501 tgctcccctg ctgtcttagg tcagtttttt atcaaaacct atatcattat attcttttat
    22561 aatactattg tcaataaaaa ttattaaaaa aataattttt ttacatttat ttttttagta
    22621 ttagctaaac tcaaaatggt gctagtccta ttttctatac aaaataatac cttgctttct
    22681 actaggactt gatttaaaat agagggcatg agtataacta aagaatttga tacaattacc
    22741 gccatttcaa cccctcttgg tgaaggagct attggcattg ttcgtctatc cgggacagat
    22801 gcgcttgcca ttgcacaatc tgtttttaag ggaaagaact tagagcaagt cgcctcacac
    22861 accattaact atggccatat cattgatcct aagacaggaa ctattatcga tgaagttatg
    22921 gtgtcagtca tgctagcccc caaaaccttt acccgtgaaa atgtagttga aatcaatacg
    22981 cacggtggta ttgctgtgac aaatgaaatc ttgcaactat tgattcgcca aggcgctaga
    23041 atggcagagc ctggcgaatt caccaaacgt gccttcttaa atgggcgagt tgatttgact
    23101 caagctgaag ctgtcatgga cattattcgt gccaaaacag acaaggctat gacgattgca
    23161 gtcaagcaac tgggtggctc cctttcccag cttatcaatg acacccgtca ggaaattctc
    23221 aacaccttag ctcaagtcga agtcaatatt gactaccctg aatacgacga tgtggaagaa
    23281 atgaccactg ctctgctacg tgagaaaaca caagaattcc aaagcctttt ggaaaatctc
    23341 cttcgaacag ctaaacgcgg taaaattctg cgtgagggct tatcaacagc tattattggt
    23401 cgtccaaacg tcggtaagtc aagcttactt aataatttgt tgcgagaaga caaggctatt
    23461 gtgactgata ttgcaggaac cacccgagat gtcattgaag aatacgttaa tatcaaggga
    23521 gttcctctaa aacttgtcga tacggccggt attcgtgaga cagatgatct ggtcgaacaa
    23581 atcggagttg aacggtctaa aaaagctctg caagaagctg accttgttct tcttgtgctg
    23641 aatgcttctg aaaaactgac cgaccaagac cgggctttgt taaatctcag tcagggcagt
    23701 aaccgtatta tattgttgaa taaaacagat ttggaacaaa agattgaatt agagcaatta
    23761 ccagatgact acattcccat ttccgtttta accaaccaga acattaatct gatcgaagat
    23821 cgtatcaacc agctcttctt tgataatgct ggactagtag aacaagatgc cacttacctg
    23881 tcaaatgccc gccacatttc tttgattgaa aaggcagtcc agagtttaga agctgtcaat
    23941 gacggcttgg cgcttggcat gccagttgat ttactacagg ttgatttaac cagaacttgg
    24001 gaaattctcg gagaaatcac aggggatgct gctcctgatg aactcattac ccaactcttt
    24061 agccaatttt gtcttggtaa ataacaacag tctctaatca tcacaaaaga gctggaacag
    24121 tgttccagct ctttttgctg tcataaacat cttatttaat taattcgtag attgcttcag
    24181 cataaatagc tgctgagcga taaatatttt ctaaaggcat atattcatta
//
