LOCUS       NZ_CP028834            10405 bp    DNA     linear   CON 25-MAY-2024
DEFINITION  Streptomyces sp. M2 chromosome, complete genome.
ACCESSION   NZ_CP028834
VERSION     NZ_CP028834.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. M2
  ORGANISM  Streptomyces sp. M2
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8718751)
  AUTHORS   Worsley,S.F., Murrell,J.C. and Hutchings,M.I.
  TITLE     The chemical ecology of Streptomyces-plant root interactions
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8718751)
  AUTHORS   Worsley,S.F., Murrell,J.C. and Hutchings,M.I.
  TITLE     Direct Submission
  JOURNAL   Submitted (09-APR-2018) Biological Sciences, University of East
            Anglia, Norwich Research Park, Norwich NR4 7TJ, United Kingdom
            (Great Britain)
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 3
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 197.99x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004104505.1-RS_2024_05_25
            Annotation Date                   :: 05/25/2024 03:18:12
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,020
            CDSs (total)                      :: 7,927
            Genes (coding)                    :: 7,816
            CDSs (with protein)               :: 7,816
            Genes (RNA)                       :: 93
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 72
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 111
            CDSs (without protein)            :: 111
            Pseudo Genes (ambiguous residues) :: 0 of 111
            Pseudo Genes (frameshifted)       :: 39 of 111
            Pseudo Genes (incomplete)         :: 91 of 111
            Pseudo Genes (internal stop)      :: 7 of 111
            Pseudo Genes (multiple problems)  :: 25 of 111
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 21:04:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6643798
            Orig. end                         :: 6654203
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP028834.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Matthew Hutchings,
            School of Biological Sciences, University of East Anglia, Norwich
            Research Park, Norwich, NR4 7TJ.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="22"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5405)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            454..1170
                     /locus_tag="DBP13_RS30635"
     CDS             454..1170
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436206.1"
                     /locus_tag="DBP13_RS30635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_128803417.1"
                     /transl_table=11
                     /translation="MKVEIWSDIACPWCYVGKARFEKALAAFPHRDRVEVVHRSFELDP
                     GRAKGDVQPVITMLTRKYGMSEAQARAGEENLGAQAAAEGLAYRTRDRDHGNTFDMHRL
                     LHFAKERGRQDELIQILYRANFAEERSVFAEGDERLVELAVAAGLDADEARTVLADPTA
                     YADEVRADEREAAELGANGVPFFVLDRKYGVSGAQPAEVFSQALTQAWGERPPLQLIDE
                     GGAEACGPDGCAVPQQ"
     gene            1334..2383
                     /locus_tag="DBP13_RS30640"
     CDS             1334..2383
                     /NRPS_PKS="Domain: Aminotran_5 (17-343). E-value: 2e-23.
                     Score: 74.8. Matches aSDomain:
                     nrpspksdomains_DBP13_RS30640_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436207.1"
                     /locus_tag="DBP13_RS30640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_128803418.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.4e-17, bitscore:
                     62.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METFESRVRTEFAPKNTYLNTASTGLLPDRTVAALRTAVEAAAAG
                     QPTDMFADVEASRASFARLARVPVRRVAAGASVAVYSGLIAGSLPEGAEVLTAQGDFSS
                     VVNPFHVRSDLKVRTAPLERLAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGA
                     RTYVDASQAAGWLDLDADADDYTACVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAG
                     EHPWDACYGPIDELAHSARRFDESPALFSYAGARRSLELLEELGVDTVRAHDLALADRF
                     RAGLASLGHEPVPSPDSPIVSVPALGHRQTELSSAGVEVSNRAGNLRAAFHLYNTDADV
                     DRLLDVLSA"
     aSDomain        1385..2362
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP13_RS30640_Aminotran_5.1"
                     /evalue="2.00E-23"
                     /label="DBP13_RS30640_Aminotran_5.1"
                     /locus_tag="DBP13_RS30640"
                     /protein_end="343"
                     /protein_start="17"
                     /score="74.8"
                     /tool="antismash"
                     /translation="YLNTASTGLLPDRTVAALRTAVEAAAAGQPTDMFADVEASRASFA
                     RLARVPVRRVAAGASVAVYSGLIAGSLPEGAEVLTAQGDFSSVVNPFHVRSDLKVRTAP
                     LERLAESVRPGTALVAVSAAQSADGRVADLPAIREAAREHGARTYVDASQAAGWLDLDA
                     DADDYTACVAFKWLVCPRGVAFLVVPEDLGGLTPLFAGWVAGEHPWDACYGPIDELAHS
                     ARRFDESPALFSYAGARRSLELLEELGVDTVRAHDLALADRFRAGLASLGHEPVPSPDS
                     PIVSVPALGHRQTELSSAGVEVSNRAGNLRAAFHLYNTDADVDRL"
     gene            2424..3029
                     /locus_tag="DBP13_RS30645"
     CDS             2424..3029
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436208.1"
                     /locus_tag="DBP13_RS30645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_108013626.1"
                     /transl_table=11
                     /translation="MESTGETSARQPADAELHRRLVYGDETALAEAYRAYGALVRRVAV
                     RVTRSPGAAEDVAQEVFAHLWSRPYAFDPDRGSLRTWLSMLAHRRAVDWVRSEARHRKD
                     AHADDAALNAIPDASPGPDETVVDRERSLLLHSALAELPRPQREVVHLAYFAGRTYRQA
                     AVELGIPEGTAKTRLRTALRSLAESLADPPDPALERGA"
     gene            3064..4065
                     /locus_tag="DBP13_RS30650"
     CDS             3064..4065
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016436209.1"
                     /locus_tag="DBP13_RS30650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="maleylpyruvate isomerase family
                     mycothiol-dependent enzyme"
                     /protein_id="WP_128803419.1"
                     /transl_table=11
                     /translation="MTDHDAVRDLLAAWAFGALPPAEEQAVPAHLAECETCAAEAARLR
                     ETVRLLDGPAVNAAPPSAASEVLSAALNARPAAPRVAAHAAPYAAAVAGVKALLPQAEG
                     RWGTPVVHDWDVHATVAHLLAADEPLAGRLGIAARVPATPEPEGVSWGDAWDRRTAEVI
                     AHEHARTPAETVADWAAQAAALLAAPEARVPELAARATMLMGVRLPIADHYVVRAFETW
                     IHSDDIGRALGLAVPPPPAGHLGQLVRLAVRVLGLALGPAAPPVLFAVDGHEQWVLGSE
                     DEPVHGELALDPVEFCLLVGGRRTPDEVPHRAAGDEGAVRNVLERAASLSWL"
     gene            complement(4107..4994)
                     /gene="thpD"
                     /locus_tag="DBP13_RS30655"
     CDS             complement(4107..4994)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003976953.1"
                     /locus_tag="DBP13_RS30655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_128803420.1"
                     /sec_met_domain="PhyH (E-value: 5.8e-39, bitscore: 133.4,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTITDLYPSRGPVEVSVPRKDPVVWGSPDTPGPISATDLQGFER
                     DGFLAIDQLIAPDEVPLYAQELERLVTDPRIRADERSIVEPKSKEIRSVFEVHKISEVF
                     AQLVRDERVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLPNMRT
                     VSVSIALTENYDTNGGLMIMPGSHRTFLGCAGETPRDNYKKSLQMQDAGTPSNEALTAM
                     ASDYGIKLFTGKAGSATWFDCNCMHGSGDNITPFPRSNVFIVFNSVENEAVEPFAAPVR
                     RPEFIGARDFTPVK"
     misc_feature    complement(4971..4985)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.64"
                     /tool="antismash"
     gene            complement(5001..5405)
                     /locus_tag="DBP13_RS30660"
     CDS             complement(5001..5405)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="DBP13_RS30660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_108013629.1"
                     /sec_met_domain="ectoine_synt (E-value: 5.3e-54, bitscore:
                     180.3, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKEIEGTDRHVKSASGTWESKRIVLAKERVGFSVHETILY
                     AGTETNMWYANHIEAVVCTKGDAELTDRETGKTYHITPGTMYLLNGHERHTLRVKEDFH
                     CICVFNPPVTGREDHDENGVYPLLTEPEEV"
     gene            complement(5489..6760)
                     /gene="ectB"
                     /locus_tag="DBP13_RS30665"
     CDS             complement(5489..6760)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 1.8e-73.
                     Score: 239.4. Matches aSDomain:
                     nrpspksdomains_DBP13_RS30665_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="DBP13_RS30665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_128803421.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-78, bitscore:
                     262.6, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRAQGSRMYDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVTHGLDMSTTAKRAFLQTFQDLVLRPRD
                     LPYKVMFPGPTGTNAVESALKLARKMKGREAIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GVPLVHGTPMPFDNYFDGQVPDFLWFERILEDHGSGLNKPAAVIVETVQGEGGINVARP
                     EWLRALSELCERQDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGLPMS
                     LCLFKPELDIWEPGEHNGTFRGNNPAFVTATAALEAYWADGSAMEKQTRARGEQVEQAF
                     VAISEENPDAVKEYRGRGLVWGMEFHDKERANRIARRAFELGLLIETSGPESEVVKLLP
                     ALTITAEELDEGLSVLARAVRETA"
     aSDomain        complement(5663..6676)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP13_RS30665_Aminotran_3.1"
                     /evalue="1.80E-73"
                     /label="DBP13_RS30665_Aminotran_3.1"
                     /locus_tag="DBP13_RS30665"
                     /protein_end="366"
                     /protein_start="28"
                     /score="239.4"
                     /tool="antismash"
                     /translation="FDRAQGSRMYDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVTHGLDMSTTAKRAFLQTFQDLVLRPRDLPYKVMFPGPTGTNAVESALKLARKMKG
                     REAIVSFTNAFHGMSLGSLAVTGNAFKRAGAGVPLVHGTPMPFDNYFDGQVPDFLWFER
                     ILEDHGSGLNKPAAVIVETVQGEGGINVARPEWLRALSELCERQDMLLIVDDIQMGCGR
                     TGAFFSFEEAGITPDIVTVSKSISGYGLPMSLCLFKPELDIWEPGEHNGTFRGNNPAFV
                     TATAALEAYWADGSAMEKQTRARGEQVEQAFVAISEENPDAVKEYRGRGLVWGMEFH"
     gene            complement(6880..7395)
                     /gene="ectA"
                     /locus_tag="DBP13_RS30670"
     CDS             complement(6880..7395)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987798.1"
                     /locus_tag="DBP13_RS30670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_108013631.1"
                     /transl_table=11
                     /translation="MTAAQADRAELQIDRPSVTDGAALWRIARDSRTLDLNSSYSYLLW
                     CRDFAGTTAVARDGRGEPVGFVTGYIRPDRPRTLLVWQVAVDEAYRGRGLAAKLLDGLV
                     ARSTGEHRITALETTISPGNTASERLFTSFAERHGADVEREVLFDTGLFPDGPHDPEVL
                     YRIGPLSF"
     misc_feature    7551..7566
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.52"
                     /tool="antismash"
     misc_feature    7678..7692
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.82"
                     /tool="antismash"
     gene            complement(7838..8938)
                     /locus_tag="DBP13_RS30675"
     CDS             complement(7838..8938)
                     /NRPS_PKS="Domain: Aminotran_5 (15-296). E-value: 3.1e-28.
                     Score: 90.6. Matches aSDomain:
                     nrpspksdomains_DBP13_RS30675_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005477727.1"
                     /locus_tag="DBP13_RS30675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_128803422.1"
                     /sec_met_domain="Aminotran_5 (E-value: 6.2e-22, bitscore:
                     76.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHPLLDLPPMSAAQFASIEDRVAKLLGTAQDVVIMQGEALLPLE
                     GAIRGTAGPGTVALNVVTGPYGQTFGNWLRDCGATVIDLSVPFHTAVSAAQIREAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVREQGALFYLDAVASIGAEPVLPDAWGVDLCV
                     VGAQKAMGGPAGVSAVSVSERAWARMAANPGAPRRSYLSLLDWKERWVDGGRRALLHAP
                     AQLEMLALEACLERIETVGLAAVMSRHASAAAATRAGALALGGGLEPYVHEAHEAAPVA
                     TTLRTPQGIIASDLVTQALTTDPALPLAAGGGALAASMIRINHYGPDATPEAVRSCLTA
                     LGTALTENGVTVDLEAARGAVAEAWA"
     aSDomain        complement(8051..8893)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DBP13_RS30675_Aminotran_5.1"
                     /evalue="3.10E-28"
                     /label="DBP13_RS30675_Aminotran_5.1"
                     /locus_tag="DBP13_RS30675"
                     /protein_end="296"
                     /protein_start="15"
                     /score="90.6"
                     /tool="antismash"
                     /translation="FASIEDRVAKLLGTAQDVVIMQGEALLPLEGAIRGTAGPGTVALN
                     VVTGPYGQTFGNWLRDCGATVIDLSVPFHTAVSAAQIREAFAEHPEIDFVSLVHAEAAT
                     GNTNPVAEIGEVVREQGALFYLDAVASIGAEPVLPDAWGVDLCVVGAQKAMGGPAGVSA
                     VSVSERAWARMAANPGAPRRSYLSLLDWKERWVDGGRRALLHAPAQLEMLALEACLERI
                     ETVGLAAVMSRHASAAAATRAGALALGGGLEPYVHEAHEAAPVATTLRTPQGIIASDLV
                     "
     gene            9138..9986
                     /locus_tag="DBP13_RS30680"
     CDS             9138..9986
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121392.1"
                     /locus_tag="DBP13_RS30680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="transporter substrate-binding domain-containing
                     protein"
                     /protein_id="WP_108013633.1"
                     /transl_table=11
                     /translation="MKTPSGRRTRILAAITATAGLVLVAACTSSDNGGSGSKTAAGGVE
                     LVKAGQLTTCTHLPYPPFQSEINGKVQGFDVSMIDLVAKNLGVKQQILDTPFENFKTGA
                     FLNSGECDLAAAGMTITAERKKNVDFSDPYFDATQALMVGKNSGITSLADAKAKKVKLG
                     AQAQTTGEDYAKKQGFDPVSFESSDAVLNGLRTGQVKAVVIDYPVVQGWLKDKANAAYK
                     VAGQINTGEQYGFTVKKGNTKLLAAINKAIKDAKADGTYKKLYEKWIGPYNASAASPSA
                     S"
     misc_feature    10341..10355
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.26"
                     /tool="antismash"
ORIGIN
        1 gaccatcgag cgccccgacg gccatgtcct gtgcgcggtc cgcgacggca gcctggtcgg
       61 catcgcctcc ttccgcaccc cggagggcgc tcccgcgaaa acggtcaagc tgttccagtt
      121 ccacgtcgac cccgaccact ggcgcaccgg cgtcggcacg gccctgcaca ccgcctgcgt
      181 cgagcagtgg caggccgacg gcagaacggc ggccgtcctc gacgtgcacg tcgacaacca
      241 ccgcgcccag gccttctacg cccgccaggg ctgggtcccc gacccggaga acccgcccgc
      301 cgaggacgac caccacctct ttctgcgctt cgcggtgccg ggggaatgac cggccctgct
      361 tgaacgttca cgcactgagg cggagggcgt ctccgaagtg ccggtgtatc cgaagtgccg
      421 gtacgtccgt acgaacggga gcgagcgaag cgcatgaagg tcgagatctg gtcggacatc
      481 gcctgtccct ggtgctacgt gggcaaggcc cgcttcgaga aggccctcgc cgccttcccg
      541 caccgcgacc gggtcgaggt cgtgcaccgc tccttcgagc tggacccggg gcgcgccaag
      601 ggcgatgtgc agccggtgat cacgatgctc accaggaagt acggcatgag cgaggcgcag
      661 gcccgggccg gcgaggagaa cctgggcgcg caggccgccg ccgagggcct cgcgtaccgc
      721 acccgcgacc gcgaccacgg caacaccttc gacatgcacc ggctgctgca tttcgccaag
      781 gagcggggcc gtcaggacga gctgatccag atcctctacc gggcgaactt cgctgaggag
      841 cgctccgtct tcgccgaggg cgacgagcgg ctcgtcgaac tcgccgtcgc ggccggactg
      901 gacgccgacg aggcccgcac ggtgctcgcc gaccccaccg cctacgccga cgaggtccgc
      961 gccgacgagc gcgaggccgc cgaactcgga gcgaacggcg tgccgttctt cgtcctcgac
     1021 cgcaagtacg gcgtctccgg cgcccagccc gccgaggtct tcagccaggc gctcacccag
     1081 gcgtggggcg agcggccgcc gctccagctg atcgacgagg gcggcgccga ggcgtgcggc
     1141 cccgacggat gcgcggtccc gcagcagtga ccccatgacc ccaaggcccc atgaaccagg
     1201 gccccatgac ccatggcccc gtgaccggcg gtccgcaaag ccgcaggtga cggccgatcc
     1261 ataaggaacg cttggcgata ccacgtagaa atcggcaatg gaccgcgggt tccgcggggc
     1321 ccacagtggg tccatggaga ccttcgagag ccgcgtccga accgagttcg ccccgaagaa
     1381 cacctacctg aacaccgcga gcaccggcct gctgcccgac cgcaccgtgg ccgccctgcg
     1441 caccgccgtc gaggcggccg ccgccgggca gcccaccgac atgttcgccg acgtcgaggc
     1501 gagccgcgcc tccttcgcgc ggctcgcccg ggtgcccgtc cgccgggtcg cggccggggc
     1561 ctcggtcgcc gtctacagcg gactgatcgc cggctccctg cccgagggcg ccgaagtcct
     1621 caccgcccag ggcgacttca gctccgtcgt gaaccccttc cacgtccgct ccgacctcaa
     1681 ggtgcgcacc gcgccgctgg agcgcctcgc cgagtccgtg cgccccggca ccgccctggt
     1741 ggcggtcagc gccgcgcagt ccgccgacgg acgcgtcgcc gacctgcccg cgatccggga
     1801 ggcggcgcgc gagcacgggg cgcgtaccta cgtcgacgcg tcccaggccg ccggatggct
     1861 ggacctcgac gcggacgccg acgactacac cgcctgcgtc gccttcaagt ggctcgtctg
     1921 cccgcggggc gtggccttcc tggtcgtccc ggaggacctc ggcggactca ccccgctgtt
     1981 cgccggctgg gtcgcgggcg agcacccctg ggacgcctgc tacggcccca tcgacgaact
     2041 cgcccactcc gcacggcggt tcgacgagag ccccgccctc ttctcctacg ccggcgcccg
     2101 ccgctccctg gaactgctgg aggaactcgg cgtcgacacg gtgcgcgccc acgacctcgc
     2161 gctcgccgac cgcttccgcg cgggcctggc ctcgctcggc cacgagcccg tcccgtcacc
     2221 cgattcgccc atcgtctccg tgcccgcgct cggccaccgc cagaccgagc tgagcagcgc
     2281 gggagtggag gtctcgaacc gcgcgggcaa cctgcgggcg gccttccacc tgtacaacac
     2341 ggacgccgat gtcgaccgcc tgctcgacgt tctgtccgcc tgaagcactg gcgcggtgcc
     2401 tgcggggacg ctaggaaggg cacgtggagt ccacgggcga gacctccgcg cggcagcccg
     2461 cagacgccga gctgcaccgg cgcctggtgt acggggacga gaccgcgctg gccgaggcgt
     2521 accgggcgta cggggctctg gtgcggcgcg tcgccgtgcg ggtcacccgc agcccgggcg
     2581 ccgccgagga cgtggcccag gaggtcttcg cccacctgtg gagcaggccc tacgccttcg
     2641 acccggaccg cggctcgctg cgcacctggc tgtccatgct ggcccaccgg cgggccgtgg
     2701 actgggtgcg cagcgaggcc aggcaccgca aggacgccca cgccgacgac gcggcgctca
     2761 atgccatccc ggacgcctcg cccggcccgg acgagacggt cgtcgaccgc gaacgctccc
     2821 tgctgctgca ctcggccctg gccgaactcc cgcggcccca gcgggaagtg gtccatctgg
     2881 cctacttcgc gggccgcacc taccggcagg ccgccgtcga actcggcatc cccgagggca
     2941 cggccaagac acggctgcgc acggctttgc gatccttggc cgagtctttg gccgacccgc
     3001 ccgatccggc gctggaacgg ggcgcatgat ggcgacacgg cacgccgggg aaggaggcac
     3061 gggatgaccg atcacgacgc cgtacgcgat ctgctggccg cctgggcctt cggcgccctg
     3121 ccgccggccg aggagcaggc ggttcccgcg cacctcgccg agtgcgagac ctgcgcggcg
     3181 gaggcggcac gcctgcgcga gacggtacgg ctgctggacg gaccggccgt gaacgccgcg
     3241 cccccgtccg ccgcctccga ggtcctgtcc gccgccctga acgcccgccc cgcggcgccc
     3301 cgggtcgccg cgcacgccgc cccgtacgcg gccgccgtcg ccggggtgaa ggcgctgctg
     3361 ccccaggccg agggccgctg gggcacaccg gtggtgcacg actgggacgt gcacgcgacc
     3421 gtcgcccatc tgctcgccgc cgacgaaccg ctcgccggac ggctcggcat cgcggcccgc
     3481 gtaccggcca ccccggagcc cgagggcgtg agctggggcg atgcctggga ccgccgtacc
     3541 gccgaggtca tcgcgcacga acacgcccgt acgcccgccg agacggtcgc cgactgggcg
     3601 gcgcaggcgg ccgccctgct cgccgcaccc gaggcccggg tgcccgaact ggcggcccgg
     3661 gccacgatgt tgatgggggt acggctgccg atcgccgacc actacgtggt gcgcgccttc
     3721 gagacgtgga tccacagcga cgacatcggc cgcgccctcg gtctcgccgt cccaccgcca
     3781 ccggccgggc acttggggca actggtgcgc ctcgccgtac gtgtgctcgg cctcgccctg
     3841 gggcccgccg cgccgcccgt gctgttcgcc gtcgacgggc acgagcagtg ggtgctgggc
     3901 tccgaggacg agccggtgca cggcgaactc gccctggacc cggtggagtt ctgtctgctg
     3961 gtcggcggcc ggcgcacccc cgacgaggta ccgcaccgcg ccgcggggga cgagggcgcg
     4021 gtcaggaacg tactggagcg ggcggcgtca ctgtcgtggc tgtgagacca cgaccgtgac
     4081 gccgcccgct gtagttgctc cgtcggtcac ttcaccggag tgaagtcccg cgccccaatg
     4141 aactcgggac gccgaacggg ggccgcgaac ggctcgaccg cctcgttctc cacgctgttg
     4201 aacacgatga agacgttgct gcgcgggaac ggcgtgatgt tgtcacccga gccgtgcatg
     4261 cagttgcagt cgaaccaggt cgccgaaccg gccttgccgg tgaacagctt gatgccgtag
     4321 tcgctcgcca tggcggtcag cgcctcgttg gagggcgtgc ccgcgtcctg catctgcagc
     4381 gacttcttgt agttgtcccg gggcgtctcg ccggcgcagc ccaggaacgt cctgtgcgac
     4441 cccggcatga tcatgaggcc gccgttggtg tcgtagttct cggtcagcgc gatcgagacg
     4501 gacaccgtgc gcatgttggg caggccgtcc tcggcgtgcc aggtctcgaa gtccgagtgc
     4561 cagtagaagc cgctggcgcc gaaaccgggc ttgacgttga tccgcgactg gtggacatac
     4621 acgtccgagc cgaggatctg ccgtgcccgg ccgaccaccc gctcgtcgcg caccagttgc
     4681 gcgaacacct cgctgatctt gtgcacctcg aagaccgagc ggatctcctt ggacttcggc
     4741 tcgacgatcg agcgctcgtc cgcgcggatt cgcgggtcgg tgacgagccg ctccaactcc
     4801 tgtgcgtaga gcggaacctc gtccggggcg atcagctgat cgatggcgag gaacccgtcg
     4861 cgctcgaacc cctgcagatc ggtcgccgag atcgggcccg gggtgtcggg cgagccccag
     4921 acgaccgggt ccttgcgcgg gacggacacc tctacggggc cgcggctggg atagagatca
     4981 gtgatggtgg tcatgtgatg tcacacctcc tcgggctcgg tgagcagcgg gtagacgccg
     5041 ttctcgtcgt ggtcctcccg tccggtcacg ggcgggttga agacacagat gcagtggaag
     5101 tcctccttga ccctgagcgt gtgccgctcg tggccgttga ggaggtacat cgtgccgggc
     5161 gtgatgtggt acgtcttccc ggtctcgcgg tcggtcagct cggcgtcgcc cttggtgcag
     5221 acgacggcct cgatgtggtt cgcgtaccac atgttcgtct cggtacccgc gtacaggatc
     5281 gtctcgtgca ccgagaagcc gaccctctcc ttggcgagga cgatcctttt gctctcccag
     5341 gtgccggacg cggacttcac atgccggtcg gtgccttcga tctccttgaa cgagcggacg
     5401 atcacggtgg tgcctagcct cctagttgat gcccagagtt gggcctttcc gggtctgttc
     5461 agggttgttc ggggttcttc agcgccgttc aggcggtctc gcgcacggcg cgggcgagga
     5521 cgctgaggcc ctcgtccagt tcctcggccg tgatcgtgag cgccgggagg agtttgacga
     5581 cctcgctctc cgggcccgag gtctcgatga gcagccccag ttcgaaggcg cggcgggcga
     5641 tccggttcgc gcgctccttg tcgtggaact ccatgcccca cacgagaccg cggccccggt
     5701 actccttgac ggcgtcgggg ttctcctccg agatggcgac gaaggcctgc tcgacctgct
     5761 cgccacgggc gcgggtctgc ttctccatcg cggacccgtc cgcccagtac gcctccagcg
     5821 cggccgtcgc cgtgacgaag gcgggattgt tgccgcggaa ggtgccgttg tgctcgcccg
     5881 gctcccagat gtccagctcg ggcttgaaca ggcacagcga catgggcagt ccgtagccgc
     5941 tgatggactt ggacacggtg acgatgtccg gggtgatgcc cgcctcctcg aacgagaaga
     6001 aggcccccgt ccgcccgcag cccatctgga tgtcgtcgac gatcagcagc atgtcctggc
     6061 gctcgcacag ctcggacagc gctcgcagcc actccgggcg cgcgacgttg atgccgccct
     6121 cgccctgcac ggtctcgacg atcacggccg cgggcttgtt caggccggag ccgtggtcct
     6181 ccaggatccg ctcgaaccac aggaagtcgg ggacctggcc gtcgaagtag ttgtcgaacg
     6241 gcatcggggt gccgtgcacc agcggaacac cggcaccggc ccgcttgaag gcgttgccgg
     6301 tgacggccag cgagccgagc gacatgccgt ggaaggcgtt ggtgaacgag acgatggcct
     6361 cgcggccctt catcttccgc gccagcttca gcgccgactc cacggcgttg gtgcccgtcg
     6421 gacccgggaa catgaccttg tacggcaggt cgcgcggccg cagcaccaga tcctggaagg
     6481 tctgcaggaa ggcgcgcttg gccgtggtcg acatgtcgag cccgtgcgtg acgccgtcgc
     6541 gctccaggta gtcgatcaac gcccgtttca gcacggggtt gttgtgtccg tagttcagcg
     6601 agccggcccc ggcgaagaag tccaggtact catgcccgtc ctcgtcgtac atgcggctgc
     6661 cctgcgcacg gtcgaagacg gtgggccagc cgcggcagta gctgcgcacc tcggactcga
     6721 gggtctcgaa gacactgagg tcgggctggg tgatggtcac gacgattcgc tcctcgttgc
     6781 gtgggggagt gcgtgggggt cgtcaggggg tctgcagaag gcttcggtga cttcttcaga
     6841 gggaggtcga aggggttcgg agtcttcttc ttcagatgtt cagaaggaga gggggccgat
     6901 gcggtacagg acctcggggt cgtgcggccc gtcggggaac aggccggtgt cgaagagcac
     6961 ctcgcgctcc acgtcggcgc cgtgccgctc ggcgaacgag gtgaacaggc gctcggaggc
     7021 ggtgttgccg ggcgagatgg tggtctcgag ggcggtgatc cggtgctcgc cggtgctgcg
     7081 tgccacgagt ccgtcgagaa gcttggccgc gagtccgcgt ccgcggtacg cctcgtccac
     7141 cgccacctgc cagacgagca gggtgcgcgg gcggtcgggc cggatgtagc cggtgacgaa
     7201 gccgaccggc tccccgcgcc cgtcgcgcgc cacggccgtg gtgccggcga agtcacggca
     7261 ccacagcaga tagctgtacg acgagttcag gtcgagcgtc ctggagtcgc gggctatccg
     7321 ccacagcgcg gctccgtccg tcaccgatgg acggtcgatt tggagttctg ctcggtctgc
     7381 ttgtgcggca gtcatgcaaa ttgaacttac cgatggaaaa tcaaaaatgc atggccggat
     7441 ggggttacgt gtgagggccg tgtgtgttat cgcgcgggcg cgagagcggg cgcaccggct
     7501 cggcgaaagg tcccattttg tgggggaaat accgcccgaa ccgggcagga tgtgtaacgc
     7561 gtcacagccg tggaacccgc acgagatctg cccgaaatac acccgttggt gttcgcggaa
     7621 tctttgcgtt taggacggga aaaagcgggc agaagaatac gggaagctgc ccccgataaa
     7681 ctcctgaaaa tcatacccga atagcgctga attcaggctc cggttactcc gtcgatacgc
     7741 tcgcgcagga tatccgcatc ctgctccggg gcgatggagg atccgccctc ctttactcgg
     7801 cccgctcccg cacccgcctg caaaccagtc cgtgcgccta cgcccaggcc tcagccacgg
     7861 ccccccgcgc tgcttccagg tccacggtca ccccgttctc ggtcagtgcc gtgcccagcg
     7921 ccgtcaggca ggagcggacc gcctccgggg tcgcgtccgg gccgtagtgg ttgatgcgga
     7981 tcattgaagc ggccagcgca cccccgccgg cggccagggg gagtgccggg tcggtggtga
     8041 gggcctgtgt gaccaggtcc gaggcgatga ttccctgagg tgtgcgtagc gtcgtggcta
     8101 ccggggccgc ctcgtgggcc tcgtggacgt acggttcgag gccgccgccg agcgccagcg
     8161 cgcccgcgcg tgtggcagcg gcggcggagg cgtggcggga catcacggcc gcgagcccca
     8221 ccgtctcgat ccgctccagg cacgcctcca gcgccagcat ctccagctgc gccggcgcgt
     8281 gcagcagcgc ccggcgcccg ccgtcgaccc agcgctcctt ccagtcgagc agcgacaggt
     8341 acgacctgcg cggcgccccc ggattcgccg ccatccgcgc ccacgcccgc tcgctcaccg
     8401 atactgccga cacgcccgcg ggcccgccca tcgccttctg cgccccgacg acgcacaggt
     8461 ccacacccca cgcgtccggc agcacgggct cggccccgat cgaggcgacc gcgtccagat
     8521 agaacagcgc cccctgctcc cgtacgacct ccccgatctc cgcgaccgga ttggtgttcc
     8581 cggtggccgc ctcggcgtgc accagcgaca cgaagtcgat ctcggggtgc tcggcgaacg
     8641 cctcccggat ctgcgcggcg ctcaccgccg tgtggaacgg caccgagagg tcgatcaccg
     8701 tcgccccgca gtcccgcagc cagttcccga aggtctgccc gtacggcccg gtgacgacgt
     8761 tcagcgcgac ggtccccggc ccggccgtcc cccggatcgc cccctccagc ggcagcagcg
     8821 cctccccctg catgatcacc acgtcctgcg cggtgccgag cagcttcgcc acccggtcct
     8881 cgatcgaggc gaactgcgcg gcgctcatcg ggggcagatc gaggaggggg tggttcacgg
     8941 cgtgctctct tcgctcacga gtgttcgact tgcgtcgagg gtatccgcca ggtgacccgc
     9001 ccctcatggc ccacccacca catgcccacc acttgagact tcgtaggccg gacaccctca
     9061 caaccatcgg tttggtttga gagacccaaa cctctcctta taatcggaac tcacagttcc
     9121 ccctcaggag gccacccgtg aagaccccct ccgggcgccg gacccgcatt ctggccgcca
     9181 tcaccgcgac ggccgggctg gtgctcgtag ccgcctgtac atccagcgac aacggcggca
     9241 gcggcagcaa gacggccgcc ggcggggtcg aactcgtcaa ggccggacag ctcaccacct
     9301 gcacccacct gccctacccg ccgttccagt cggagatcaa cggcaaggtg cagggcttcg
     9361 acgtgtcgat gatcgacctc gtcgccaaga acctcggcgt caagcagcag atcctcgaca
     9421 cgcccttcga gaacttcaag accggcgcgt tcctcaactc cggcgagtgc gacctggccg
     9481 cggccggcat gaccatcacc gccgagcgca agaagaacgt cgacttctcc gacccgtact
     9541 tcgacgccac ccaggccctg atggtcggca agaacagcgg catcacctcg ctcgccgacg
     9601 ccaaggccaa gaaggtcaag ctcggcgccc aggcacagac caccggcgag gactacgcga
     9661 agaagcaggg cttcgacccg gtctccttcg agtcctccga cgccgtcctc aacggcctgc
     9721 gcaccggcca ggtcaaggcc gtcgtcatcg actacccggt ggtccagggc tggctgaagg
     9781 acaaggccaa cgccgcctac aaggtggccg gccagatcaa caccggtgag cagtacggct
     9841 tcacggtgaa gaagggcaac accaagctcc tcgccgccat caacaaggcg atcaaggacg
     9901 ccaaggccga cggcacgtac aagaagctgt acgagaagtg gatcggcccc tacaacgcgt
     9961 ccgcggcctc cccctccgcc tcatgacggc atccgacgta cgactccagc cccgcaagaa
    10021 gggcctgacc cgcacccaga agcgcaccct gtcccgcggc gcgcagtacg tcgtcttcgt
    10081 cgccgccgtg atcgccttcg cggtctcggc ggactggggc cggctgaaga accagttcgc
    10141 gcagtggagc atcgccaagc agatgttccc cgacgtgatc acgctggcgc tgaagaacac
    10201 cgtgctgtac acgctgtccg gcttcgtcgt cggactggtg ctcggcatgg tgatcgcgct
    10261 gatgcggctg tcctcggtgg gtccctaccg ctggctcgcc ggcatctaca tcgagatctt
    10321 ccgcggcctg cccgccctgc tgatcttcat cttcatcggc gtcgcggtgc cgctcgcctt
    10381 ccccggcacg gagatcgtcg gcggc
//
