LOCUS       NZ_CP034669            10825 bp    DNA     circular CON 19-MAY-2024
DEFINITION  Corallococcus coralloides strain B035 chromosome, complete genome.
ACCESSION   NZ_CP034669
VERSION     NZ_CP034669.1
KEYWORDS    RefSeq.
SOURCE      Corallococcus coralloides
  ORGANISM  Corallococcus coralloides
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Corallococcus.
REFERENCE   1  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Complete Genome Sequence of the Corallopyronin A producing
            Myxobacterium Corallococcus coralloides B035
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2018) Institute for Pharmaceutical Biology,
            University of Bonn, Nussallee 6, Bonn, NRW 53123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-SEP-2017
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 350.5x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004104415.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:23:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,767
            CDSs (total)                      :: 7,695
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 72
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 30 of 79
            Pseudo Genes (incomplete)         :: 55 of 79
            Pseudo Genes (internal stop)      :: 4 of 79
            Pseudo Genes (multiple problems)  :: 10 of 79
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:35:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7817795
            Orig. end                         :: 7828620
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034669.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Gabriele M. Koenig,
            Institute for Pharmaceutical Biology, University of Bonn.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10825
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="34"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10825
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10825
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5825](-)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5825)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     misc_feature    complement(238..252)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.1"
                     /tool="antismash"
     gene            complement(696..3392)
                     /locus_tag="EJ065_RS31290"
                     /old_locus_tag="EJ065_6219"
     CDS             complement(696..3392)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399294.1"
                     /locus_tag="EJ065_RS31290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6219"
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_128799041.1"
                     /sec_met_domain="PPDK_N (E-value: 2.1e-51, bitscore: 173.9,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAPQPLVSMTEAGDPQHVGQKFARQQHLARHGFPVPEFFCLTTT
                     MFQEVAAPLQADINRLTTAVDRTSHQDIRRVAEEIEKRFLQVPLGAEREATILDAFDRT
                     FGARGMVAVRASVVGRALEESEDSETDPFAGVSSTFLYVRRDMLLDRIRRCWASAYTPE
                     GLIYRLAQGRDVRGLMVAVGVQRMIPGRRSFVAFTCDPKTTERRTLVVAGHGIGEGVVQ
                     EKVGVDHYFIHPETGHIDRELAHKADMLCENPEPGGELVRRPVPEPLRDAPCLTDEELK
                     RLATLAKDIERSFGMPQDIEGTFTEDGTLHVLQARPIAFDFRKIRVWGCGNVSESFPGV
                     TTPLTYSLASYFYEVIFYDLLRRMKGADARALHDQTPAFQNMLGFIDGRVYHSLSNLMH
                     VNGINPFIAATSMRDLEDVLQRDASLVIRLPGHRESFPSTASYAYALGRSALGALTVTA
                     TFQRDFEAFEAWWKRTLAGLRALPVEKEDPLVLIHHFRRVWTEVGNWWGLTLINHWYIN
                     TCFGLARRLLLKWTGEDPSALLVGLMCGAKPDAGTHALLSAVALAEMVRADPALAKRFD
                     EGEAEALWRSIDAGDVPPGVARAFREHLSEFGDRGVQELNVERPNLRDTPWDLVRVVQS
                     YARSSVTREELRASDRARRTEAEAQLATLLQGHPLRKLAIEKLLAGLRTVIGLREDSRF
                     WRGQLFGFSKQVFAALGQRMAERGVLDAPLDVHYLTMREVLDHFEGRSVTRNLGELARL
                     RRREQQDNQERQPPRDFTTVGSVADGIPRVVEAASDNASLFKGIGSSAGIVEGTARIVL
                     DPGAVGSLGKDDILIAKETDPGWLFLMLASGGIVVERGSMLSHTAIAGRKFGIPTVVGV
                     ANATTRIPDGARVRVDGSTGTVTLVAA"
     gene            complement(3407..4369)
                     /locus_tag="EJ065_RS31295"
                     /old_locus_tag="EJ065_6220"
     CDS             complement(3407..4369)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399295.1"
                     /locus_tag="EJ065_RS31295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6220"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_128799042.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 5.5e-05, bitscore:
                     21.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLVGGFGVVLTGATGMVGQAFLRQRGAHPVHALVRSPDGREWGD
                     GVHVVRGDLHGIPEALFPPYPYVALHLATKQRDTDGTGYERTNVDGTRRLLSRLTGDCR
                     GVLFGSSMSVYGAGPHRGVKEDHPLRPITALARSRVAAEDVITEHAVRTGLHAALLRPR
                     FLLGRGDRFVLPAMVKLLKQGVQVGGDAVGCSVIDVDDLGRILWMLARRMVETPRSEQQ
                     AFNVAYSQPLLRGEFLGTVGRGLGLPPPLVTVRAPGWLPRVLRDVPSRRARAMAERLEL
                     LIHSQCLDVSRLAAVLGPEDLLARSPVDALRSALNDFRS"
     gene            complement(4357..5004)
                     /locus_tag="EJ065_RS31300"
                     /old_locus_tag="EJ065_6221"
     CDS             complement(4357..5004)
                     /EC_number="2.1.1.100"
                     /EC_number="2.1.1.334"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399296.1"
                     /locus_tag="EJ065_RS31300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6221"
                     /product="isoprenylcysteine carboxylmethyltransferase
                     family protein"
                     /protein_id="WP_128799043.1"
                     /transl_table=11
                     /translation="MKGLHRWMPTLLLVTGVGLLIPLGLRQVLRTPEDSRPIAALMLGL
                     YLTWMLVESRVTLRETQKPTAERDSATLELYAIGRLATILLAVAFPALELGPVPRAVGL
                     FCFIAGVSLRLTAIRTLGKAYSHRVRLPDASLLVTEGVYRRLRHPAYTGMLLAHVGYLL
                     VFPAVVGIAVFALLFVPAVLLRIRHEERLLLGSFPGYAEYAASRKRLVPWVW"
     gene            complement(5001..5825)
                     /locus_tag="EJ065_RS31305"
                     /old_locus_tag="EJ065_6222"
     CDS             complement(5001..5825)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399297.1"
                     /locus_tag="EJ065_RS31305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6222"
                     /product="AfsA-related hotdog domain-containing protein"
                     /protein_id="WP_128799044.1"
                     /sec_met_domain="AfsA (E-value: 7.9e-21, bitscore: 72.7,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSVSSHPERRLRVASPEAVPFLLVPEPLLSGVEHPCRIPVKNVE
                     EAEFLAAVLQEHCGLYLGARAAEFPALAEWADATPVGVRVGEQWKKEPPENVSELLARI
                     PVRNAVSAGRQSFTEAEQARPLERVDPVLVHKRDPANVLLANACRVGALHQFNAFTDSP
                     EFVFDHPSEHVQGMLLTELARQAAIAAIHGVGLPLDWSLILTRLTLEFRRFVRNDVPVV
                     IRTFASFRLPEWAEPVRSDGRRNRMWIAVQGWQEDTCCYSGLIGAVSAKAAS"
     misc_feature    complement(5810..5824)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.34"
                     /tool="antismash"
     gene            6257..8782
                     /locus_tag="EJ065_RS31310"
                     /old_locus_tag="EJ065_6223"
     CDS             6257..8782
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014544.4"
                     /locus_tag="EJ065_RS31310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6223"
                     /product="HYR domain-containing protein"
                     /protein_id="WP_164933349.1"
                     /transl_table=11
                     /translation="MGMVIGRAWLSALSLVVGAAPAFAQGSSVQLDPMTVRRVADVTSA
                     PRLELDFRGPDTRPTVELNGRLYFLATPGSAGSGSDVRELWVTDGTSAGTRSVHEELLP
                     AGASIDPGSLRATPHRLFFTATTTQTGRELWTSDGTREGTHVTRELTPGPIHGLAAQAP
                     LFVFGDSVLFVPADTQADLWRSDGTAEGTVPVKDIHPGFARANAAGFARVGDTVFFAAE
                     DERGFELWRTDGTEAGTTLVRDIKAGVGDSYPESLTAVGDTLYFTAEDGQHGRAVWKSD
                     GTEAGTVLVKDFNTAVTGRMPTVLAALGDALVFLVRSSEEASQLWRTDGTDAGTQQLAQ
                     VPSGMLSGYSGQFFVPAGSRLYFVSRGATLGDSLWVTDGTAAGTRHLPRPIPYGNESVR
                     GVAPWEDGLAVIVTTQAGASELWRTDGTDAGTSRLTRLPSGREFALPTGLVPFQGALLT
                     TAGDPWTPHALWRMERDEAAPTFLCPAAQDMPSNRPEGTDLLHYRPELRTGAEQAWIRT
                     SFIDGQLLPLNLPITVTYQAGDAQGRLTYCTTVLTSRDLTSPAIHNCPTELILNAQSAR
                     GTTFYYPNLGIGDETSRDVLTVFSPTNGSVLPLGTTQMNVTARDASGNESTCSFPVTVR
                     DDQAPGRACKVNEVRVEAEGPEGAHAFWPDLTPTDSLSTKVTVTSTHASGDLFPLGLTR
                     VEVVSTDEAGNSTPCEIQVRVRDSRPPLLTCPEDQTLTTAVMSGTRAEYPAATAADSVS
                     EAELLYSPVVGTPLAPGLHAVQVTAIDKAGNAALCNFHVTVQYDPTSDMRTSMGCSVGS
                     GPESAVGWGALVALAWTLSRRLKDGKPRA"
     gene            8836..9378
                     /locus_tag="EJ065_RS31315"
                     /old_locus_tag="EJ065_6224"
     CDS             8836..9378
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399302.1"
                     /locus_tag="EJ065_RS31315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6224"
                     /product="DUF350 domain-containing protein"
                     /protein_id="WP_128799046.1"
                     /transl_table=11
                     /translation="MDLTLFVVGLMKVVLGGLVAALGIGLSMRGLSRLLDSHPVEELRQ
                     GNVASGLVHATSLVSLGLLVQHALKATGDAVDLAVQNPPVSALSVLQLLGLALVHVALS
                     LAVGVAVLALGVRLFDKMTPGIEELEEVRKGNIAAALLLCAFLLVIALLTAPGLQAALN
                     GLIPFPQLPTGVLRAPA"
     gene            9386..10258
                     /locus_tag="EJ065_RS31320"
                     /old_locus_tag="EJ065_6225"
     CDS             9386..10258
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014399303.1"
                     /locus_tag="EJ065_RS31320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_6225"
                     /product="hypothetical protein"
                     /protein_id="WP_128799047.1"
                     /transl_table=11
                     /translation="MLARSWKTLLSLVLMGALMAFASWELVVARKAGRLPDPPRPPTEV
                     PPADPQEARRDLGFVLVPEDTPPERAKSYDWRVDGMEPARQQLAYGLGEAVERGLVQAH
                     RDYSVRLRYRAMGPERFTYVAPPGCGTDMRCIYAELMKSNAEPVRVLGERFATSIRERD
                     LDAAQATELILGFVRRIRYELPGDEPFGIVPPGLVPAQDRGDCDSKAVLALMLLRQVGV
                     DAVMLYSDALAHAAIGVGLPGTGTRIPFAGRGYQYAELTAEGWPLGMIPPQYDKPQLWR
                     VLPLPDVQG"
ORIGIN
        1 catcgcgaag gcaatcaccg cgctggccgt ggagctcact tcgtcgctgt agagcttctc
       61 ccctggcttc gtggtcccgg gccacgcggt cttccgcatc acctcccagt gcaggtacag
      121 gaagaccatt gccaggatgg ccaacagccc gtgtgggttc agcggccttc cggtgcgctc
      181 cgcgtgcgca accaagacgt agaggccgtg gcccacgtgg agctggatgg cgattccaat
      241 catcaggaac atgctgcgct ggtacgcgac ccagtgcttc tccagcgccc agagcaccag
      301 cgcatgcacc atgatgccca gcaggatggc ggccctcacc caggacaccg ccaggttcgt
      361 cccgagcaac acggccgcgt tgagccccag cgccacgtac aggtccccga agctgacgtc
      421 ccctttcgcc agaccccggt tggggttgtg gaccaggtcg tattcgtagt cgcgcagctc
      481 atccacgatg cgcatgaagt agcccacgcc gaagatgctc agcgcgacgt gcagcaggtc
      541 cggggagaac ttcagccccc ctcccccgtc gagcactccg aacatcccgt ccaggatcac
      601 gcaccagagt gaaatcacca gcaggtagaa cagcggcggg taacgctgca cggagaagcg
      661 cagcgtcgcc ctcgcccggg ccatgacggt cctgctcatg ccgccaccag cgtgacggtt
      721 cccgtggaac catccactcg gaccctcgcc ccgtccggga tgcgcgtggt cgcattcgcc
      781 actcccacca ccgtggggat gccgaacttc cggcccgcga tggctgtgtg cgacagcatg
      841 ctgccgcgct ccaccacgat gcctcccgac gccagcatca ggaacagcca accggggtcc
      901 gtctcctttg cgatgaggat gtcgtccttg cccagcgagc ccaccgcgcc cgggtccagc
      961 acgatgcgcg cggtcccctc cacgatgccc gcgctcgaac cgattccctt gaacagcgag
     1021 gcgttgtcgc tcgcggcctc cacgaccctc gggatgccgt ccgccacgct gcccaccgtg
     1081 gtgaagtccc ttggcggctg acgctcctgg ttgtcctgct gctccctccg ccgcagcctc
     1141 gcgagctcgc ccaggttcct cgtgacgctt cggccttcga agtggtccag cacctcgcgc
     1201 atcgtgaggt agtgcacgtc cagcggcgca tccagcacgc cccgctccgc catccgctgt
     1261 ccgagcgccg cgaacacctg cttgctgaag ccgaagagct ggcctcgcca gaaccggctg
     1321 tcctcgcgca ggccaatcac cgtccgcagc cctgccagga gcttctcgat ggccagcttc
     1381 cgcagcggat gcccctggag gagcgtggcc agctgtgcct ccgcctccgt gcgccgagcc
     1441 ctgtccgacg ccctcaactc ctcacgcgtc acggatgacc gcgcgtagga ctggacgact
     1501 cgcaccaggt cccacggcgt gtcccgcagg ttcgggcgct ccacgttcag ctcctgcacg
     1561 ccccggtccc cgaactcgct caggtgctca cggaaggcgc gagcaacccc aggcggcacg
     1621 tcccccgcgt cgatgctccg ccagagggcc tccgcctcgc cttcgtcgaa gcgcttcgcc
     1681 agcgccggat ccgctcgcac catctccgcg agcgccaccg cggagagcag cgcgtgggtg
     1741 ccagcgtccg gcttcgctcc gcacatcagg cccaccagca acgcgctggg gtcttccccg
     1801 gtccacttga ggagcagcct gcgcgccagc ccgaagcacg tgttgatgta ccagtggttg
     1861 atgagcgtca gcccccacca gttccccacc tccgtccaga cgcgccggaa gtgatggatg
     1921 aggaccagcg ggtcctcctt ctccaccggc agggcccgga gccccgcgag cgtccgcttc
     1981 caccaggcct cgaacgcttc gaagtccctc tggaacgtcg cggtgacggt cagcgcgccc
     2041 agcgccgagc gccccagcgc gtatgcgtag ctcgccgtgc tggggaagct ctcacggtgg
     2101 cccggcagcc ggatgaccag cgacgcgtca cgctggagca cgtcctccag gtcccgcatg
     2161 gaggtcgccg cgatgaacgg gttgatgcca ttgacgtgca tcaggttcga cagcgagtgg
     2221 tagacgcgcc cgtcgatgaa ccccagcatg ttctggaacg cgggcgtctg gtcgtgcagg
     2281 gccctcgcgt ccgcgccctt catgcggcgc agcaggtcgt agaagatgac ctcgtagaag
     2341 tagctggcca gtgagtacgt cagtggcgtc gtgacacccg ggaagctctc cgagacgttg
     2401 ccgcaacccc acacacggat cttccggaag tcgaaggcga tgggccgcgc ctgcaacacg
     2461 tgcagcgtgc cgtcctcagt aaaggtgccc tcgatgtcct ggggcatgcc gaagctgcgc
     2521 tcgatgtcct tcgccagcgt ggccagccgc ttcagttcct catccgtgag acacggcgcg
     2581 tcccgcaggg gctccggcac gggccggcgg accagctcgc ctccgggctc ggggttctcg
     2641 cagagcatgt ccgccttgtg ggccagttcc cggtcgatgt gacccgtctc cgggtggatg
     2701 aagtagtggt ccacgcccac cttctcctgg accaccccct ccccgatgcc gtgccccgcg
     2761 acgaccaggg tgcgccgctc ggtcgtcttc gggtcgcacg tgaaggccac gaacgagcgg
     2821 cggccgggga tcatccgctg cactcccacc gcgaccatca gcccccgtac gtcgcggccc
     2881 tgcgccagcc ggtagatgag cccctccggt gtgtaggcgg aggcccagca gcggcggatg
     2941 cggtccagca gcatgtccct ccgcacgtag aggaacgtgg agctcactcc cgcgaacgga
     3001 tccgtctccg agtcctcgct ctcctccagc gcccggccca ccacggaggc ccgcacggcc
     3061 accatgccgc gcgcgccgaa ggtccggtca aaggcatcca ggatggtggc ttcgcgctcg
     3121 gctcccaacg ggacctggag gaagcgcttt tcaatctcct ccgcgacgcg gcggatgtcc
     3181 tgatgcgacg tccggtccac cgccgtggtg aggcggttga tgtcggcctg gaggggagcc
     3241 gccacctcct ggaacatcgt ggtggtgagg cagaagaact cggggaccgg gaagccgtgc
     3301 ctcgccaggt gctgctggcg cgcgaacttc tggccgacgt gctgcgggtc accggcctcg
     3361 gtcatcgaga cgagcggttg gggggcaggc atgacagggg attccttcag gaacgaaagt
     3421 cattgagcgc gcttcgcagg gcatccaccg gggacctcgc caacaggtcc tccggcccga
     3481 gcaccgccgc gagccgcgag acatccagac actgtgaatg gatcagcaac tccaagcgct
     3541 ccgccatcgc ccgggcccga cggctgggga catcccgcag gactcgcggg agccagccgg
     3601 gggcacggac cgtcacgagt ggagggggca ggcccagccc ccgccccacc gtgcccagga
     3661 actctcctcg caggagcggt tgtgagtacg cgacgttgaa cgcctgttgt tcggaacgcg
     3721 gcgtctccac catccgccgc gcgagcatcc agaggatgcg ccccaggtca tccacgtcga
     3781 tgaccgagca ccccaccgcg tcgcccccta cctgcactcc ctgcttcagg agcttcacca
     3841 tcgcgggcag gacgaaccgg tccccgcgcc ccaggaggaa gcgcggccgg agcagcgccg
     3901 cgtgcagccc ggtccggaca gcgtgttcgg tgatgacgtc ctcggccgcc acgcgcgaac
     3961 gggccagcgc ggtgatgggc cggagcggat ggtcctcctt cacgccccgg tggggacccg
     4021 cgccataaac agacatggag ctgccgaaga gcacaccccg gcaatccccc gtgagccgcg
     4081 acagcagccg ccgcgtccca tccacgttgg tccgctcgta gcccgtgccg tccgtgtccc
     4141 gctgcttcgt ggccagatgc aaagccacat acggatacgg cggaaacaac gcctctggaa
     4201 tgccgtgcag gtctccccgc acgacgtgca caccgtctcc ccactcgcgg ccgtcgggcg
     4261 agcgcaccag cgcgtgcacg ggatgcgctc cgcgctggcg caggaacgcc tgccccacca
     4321 tgccggtcgc gcccgtgagc acgacgccga agccgcctac cagacccatg ggaccagccg
     4381 cttgcggctc gccgcgtact cggcgtagcc cgggaaggag cccagcaaga gccgctcttc
     4441 gtgccggatg cgcaggagga ccgccgggac gaacagcagc gcgaacaccg cgatgcccac
     4501 gaccgcgggg aacaccagca ggtagcccac gtgcgccagc agcatgccgg tgtacgccgg
     4561 gtgccggagc ctccggtaca cgccttccgt cacgagcagg ctcgcgtccg gcagccgcac
     4621 ccggtgcgaa taggccttcc ccaacgtgcg gatggccgtg agccgcagcg acaccccggc
     4681 gatgaagcag aacagcccca ccgctcgcgg caccggcccc agctccaacg cggggaacgc
     4741 gaccgccaac agaatggtcg ccagacgccc tatcgcgtag agctccagcg tggcgctgtc
     4801 ccgctccgcg gtgggcttct gcgtctcccg cagcgtcacc cggctctcca ccagcatcca
     4861 cgtcaggtat aggcccagca tcagggccgc gatgggccgg ctgtcctctg gcgtgcgcag
     4921 cacctgccgc aagcccagcg gaatcagcag ccccacgccc gtcaccagca gcagcgtggg
     4981 catccaacgg tgcaggccct tcatgacgcc gccttcgcgc tcacggcgcc aatcagcccc
     5041 gagtagcagc aggtgtcctc ctgccagccc tgcacggcga tccacatgcg gttgcggcgc
     5101 ccgtcgctgc gcaccggctc cgcccactcc gggagccgga agctggcgaa ggtgcggatc
     5161 accaccggca cgtcgttgcg cacgaagcgc cggaactcca acgtcaggcg cgtcaggatg
     5221 agcgaccagt ccagcggcag ccccacgccg tggatggccg cgatggccgc ctgccgggcc
     5281 agctccgtga ggagcatgcc ctgcacgtgc tcggagggat ggtcgaagac gaactccggc
     5341 gaatcggtga acgcgttgaa ctgatggagc gcccccaccc ggcaggcgtt ggcgagcagc
     5401 acgttcgccg ggtcgcgctt gtgcacgagc accggatcga ctcgctccag cggccgggcc
     5461 tgctccgcct cggtgaagga ctgtcgtccc gcggagacgg cgttgcgcac ggggatgcgg
     5521 gccaggagct ctgagacgtt ctccggcggc tccttcttcc actgttcgcc cacgcgcacg
     5581 cccaccggcg tggcgtccgc ccactccgcc agcgcgggga actcggcggc tcgcgcgccc
     5641 aggtagaggc cgcagtgctc ctgaagaacg gcggccagga actccgcctc ctccacgttc
     5701 ttcaccggga tgcggcaggg gtgctcgact cccgaaagaa ggggctccgg cacgagcagg
     5761 aatgggacgg cctccggcga ggccacccgc aagcggcgct cgggatgact ggaaacggaa
     5821 tccatgtctg ccttctccaa ctgaggggga aagacagcct aggaatcgcg atgcctcaac
     5881 acgagaaccg gggaaggccc gctttcacga ggcgggagat cagacccaga gggattcgcg
     5941 ggcctgtttc atgaaccatc atgacacgtc gcgaaatgcg tcttggattg agacagccgg
     6001 tgcgagcctg ggttcacggc ccctcgggag actccggttc gcggcggacc cgcgcctcca
     6061 gctcctcccc acgaccaccc aggtagaggg ttcccgcggc agcggccggt ggtgaacacc
     6121 tgaacccggt aggacaccgg cggtgcgcaa tctgtcggac agtcggacag gtcgtgggtt
     6181 gtagcccggc gggggcgtga tgacggtgcg cctccagcag gacaggtggc gggcaggcgg
     6241 gcgtggaggg gcgggcatgg ggatggtcat cggtcgtgca tggctttcgg cgttgtcgtt
     6301 ggtggtgggc gcggccccgg cgttcgcgca aggatcctcc gtccaactgg acccgatgac
     6361 ggtgcgccgg gtggcggacg tcacctccgc accccgcctg gagctggact tccggggacc
     6421 tgacacgcgg cccaccgtgg agctgaacgg gcgcctctac ttcctcgcca ccccgggcag
     6481 cgccggctcc ggctccgacg tccgggagct gtgggtgacg gacgggacgt ccgcgggcac
     6541 ccgctccgtg cacgaggagc tgctgcccgc gggtgcgagc atcgacccgg gctcgctgcg
     6601 cgccacgccg caccgcctgt tcttcaccgc gacgacaacg cagaccggac gcgagctgtg
     6661 gacgagcgac ggcacgcgag agggcaccca cgtcacgcgc gagctcaccc ccggccccat
     6721 ccatggcctc gccgcccagg cgcccctctt cgtcttcggg gactccgtgc tcttcgttcc
     6781 ggcggacacg caggccgacc tctggaggtc ggacggcacg gccgagggca ccgtgcccgt
     6841 caaggacatc catccggggt tcgcccgagc gaacgccgcg ggcttcgcgc gcgtggggga
     6901 cacggtcttc ttcgccgcgg aggacgagcg gggcttcgag ctgtggcgca cggatggcac
     6961 cgaggcgggc accaccctcg tgcgcgacat caaggccggc gtcggcgact cgtatcccga
     7021 gagcctcacc gcggtgggcg acacgctcta cttcaccgcg gaggacggcc agcatggccg
     7081 cgcggtctgg aagtccgacg gcacggaggc cggcaccgtc ctcgtcaagg acttcaatac
     7141 cgccgtcacg ggccgcatgc ccaccgtgct cgccgccctg ggcgacgcgc tcgtcttcct
     7201 cgtgcgcagc tccgaggagg cttcccagct gtggcgcacg gacggcaccg acgcggggac
     7261 ccagcagctg gcgcaggtgc ccagcgggat gctcagtggc tattcgggcc agttcttcgt
     7321 cccggcgggc agccgcctct acttcgtgtc ccggggcgcc acgctcgggg actcgctgtg
     7381 ggtgacggac ggaacggccg cgggcacgcg gcacctgccg cgccccatcc cgtacgggaa
     7441 cgaatccgtg cgcggcgtgg cgccgtggga ggacgggctc gccgtcatcg tgaccacgca
     7501 agcgggagcg agcgagctgt ggcgcacgga cggcaccgac gcgggcacgt cccggctgac
     7561 gcggctgccg tcgggcaggg agttcgcgct gcccacgggg ctggtgccgt tccagggcgc
     7621 gctgctgacg acggccggag acccgtggac gccccacgcg ctgtggcgca tggagcggga
     7681 tgaagcggcg ccgaccttcc tgtgcccggc cgcccaggac atgccctcca accgtccgga
     7741 gggcacggac ctgctccact accggcccga gctgcgcacc ggagcggagc aggcgtggat
     7801 ccgcacctcc ttcattgacg gccagctgct tccgctcaac ctgcccatca ccgtcaccta
     7861 ccaggccggg gatgcgcagg gccgcctcac gtactgcacc acggtgctga cgtcgcggga
     7921 cctgacgtcg ccggccatcc acaactgccc gacggagctc atcctgaacg cgcagtcggc
     7981 ccggggcacg accttctact atccgaacct gggcatcggg gatgagacga gccgcgacgt
     8041 gctcaccgtc ttcagcccga cgaacggcag cgtgctgccc ctgggcacca cccagatgaa
     8101 cgtgacggcg cgggacgcgt ccggcaacga gagcacctgc tccttccccg tcaccgtgcg
     8161 cgacgaccag gcgcccggcc gggcctgcaa ggtgaacgag gtccgcgtgg aggcggaggg
     8221 gcccgagggc gcgcacgcgt tctggccgga cctcacgccc accgacagcc tgtccaccaa
     8281 ggtcaccgtc accagcacgc acgcgtccgg ggacctgttc ccgctgggcc tcacccgcgt
     8341 ggaggtcgtc agcaccgatg aagcgggcaa cagcaccccg tgcgaaatcc aggtccgggt
     8401 gcgcgactcg cgaccgcccc tgcttacctg cccggaggac cagacgctga ccaccgcggt
     8461 gatgtccggc acccgcgcgg agtacccggc cgccaccgcc gcggacagcg tctccgaagc
     8521 ggagctcctc tacagccccg tcgtgggcac gccgctcgcg ccgggcctgc acgcggtgca
     8581 ggtcaccgcc atcgacaagg ccggcaacgc ggcgctctgc aacttccacg tgaccgtgca
     8641 gtacgacccg acgagcgaca tgcggacgag catgggctgc tcggtgggca gcggcccgga
     8701 gtcggcggtg ggctggggcg cgctcgtcgc cctcgcctgg acgctcagcc gccgtctgaa
     8761 ggacggcaag ccgcgcgcgt aagtcatgag ccgtggcggc gagggggact tccgctacag
     8821 tcccctgcgc gccccatgga cctcaccctc ttcgtcgtcg gactcatgaa ggtcgtcctc
     8881 ggcggcctcg tggccgcgct cggcatcggc ctgagcatgc gcggcctgag ccgcctgctg
     8941 gacagccacc ccgtggagga gctgcgccag ggcaacgtcg cctccgggct ggtgcatgcg
     9001 acgagcctcg tgtcgctggg cctgctggtg cagcacgcgc tgaaggccac gggcgacgcg
     9061 gtggacctgg cggtgcagaa cccacccgtg tccgccctct cggtgctcca gctgctgggc
     9121 ctggcgctgg tgcacgtggc gctgtcgctg gcggtgggcg tggcggtgct cgccctgggc
     9181 gtgcgcctgt tcgacaagat gacgccgggc atcgaggagc tggaggaggt gcgcaagggc
     9241 aacatcgccg ccgcgctcct cctgtgcgcc ttcctgctgg tcatcgcgct gctcaccgcg
     9301 ccgggcctcc aggccgcgct caacgggctc atccccttcc cgcagctgcc caccggcgtg
     9361 ctgcgcgcgc ccgcctgaag ccgccatgct cgcgcgctcg tggaagacgc tgctgtcgct
     9421 ggtgctgatg ggcgcgctca tggccttcgc cagctgggag ctcgtggtgg cccggaaggc
     9481 gggccggctt ccggatcctc cccggccgcc gacggaagtc cccccggcgg acccacagga
     9541 ggcgaggcgg gacctgggat tcgtgctggt gccggaggac acgccgccgg agcgcgcgaa
     9601 gtcctatgac tggcgcgtgg acgggatgga gcccgcccgt cagcagctgg cctacggact
     9661 gggcgaagcg gtggagcgcg ggctggtgca ggcgcaccgc gactacagcg tgcggctgcg
     9721 ctaccgcgcc atgggcccgg agcgcttcac ctacgtggca ccgccaggct gcggcacgga
     9781 catgcgctgc atctacgcgg agctgatgaa gagcaacgcg gagccggtgc gcgtgctggg
     9841 cgagcgcttc gccacctcca tccgcgagcg cgacctggac gcggcgcagg ccaccgagct
     9901 catcctcggc ttcgtgcgcc gcatccgcta cgagctgccc ggcgacgagc ccttcggcat
     9961 cgtcccgccg gggctggtgc ccgcgcagga ccggggcgac tgcgattcca aggcggtgct
    10021 cgcgctgatg ctgctgaggc aggtgggcgt ggacgcggtg atgctctatt cagacgcgct
    10081 cgcgcacgcg gccatcggcg tggggctgcc cggcaccggc acccgcatcc ccttcgcggg
    10141 gcgcgggtac cagtacgcgg agctcaccgc cgaaggctgg ccgctgggga tgattccgcc
    10201 gcagtacgac aagccccagc tgtggcgggt gctgccgctg ccggacgtac agggctgaag
    10261 cgcccctggc gattcgccgc gaatacagct attcctgttc tatccgggat gctcgccaca
    10321 gggcgggccg tcccttaccc aagcgggggc aggcacatgg cggattcgcg gacgtggatg
    10381 acggcggggc tgttggcgct ggccagcggc tgtggcgcac aggaggacgc ggtgatgccg
    10441 gccgcggtgg agcaggcgct gggcgcgtgc acgcactcgg tgacgacgaa cacgtacgac
    10501 ggcccgctgt actggggcac gctggtgttc aagaacacgg gcacggtggc catcaccaac
    10561 ccccacatcc tcttggacgt gccgtcgggc gcgacgtgtg attacgaccc ggcgggctgg
    10621 acgcatacgc agtccggccg cacgtgctcc ttcacgcgca cgtcggcgct gacggtggcg
    10681 gtcaacgcgt cgtacacgtt caactactcc accaactcca acgcgtcgtg gaccgcgacc
    10741 aacgtgcgcg tccagtccga cagctgcggc ggcacgtccc ctggcggctc cggcctcacc
    10801 gcgaaccaga agaaggtggc cgaag
//
