LOCUS       NZ_CP034669            10849 bp    DNA     circular CON 19-MAY-2024
DEFINITION  Corallococcus coralloides strain B035 chromosome, complete genome.
ACCESSION   NZ_CP034669
VERSION     NZ_CP034669.1
KEYWORDS    RefSeq.
SOURCE      Corallococcus coralloides
  ORGANISM  Corallococcus coralloides
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Corallococcus.
REFERENCE   1  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Complete Genome Sequence of the Corallopyronin A producing
            Myxobacterium Corallococcus coralloides B035
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2018) Institute for Pharmaceutical Biology,
            University of Bonn, Nussallee 6, Bonn, NRW 53123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-SEP-2017
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 350.5x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004104415.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:23:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,767
            CDSs (total)                      :: 7,695
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 72
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 30 of 79
            Pseudo Genes (incomplete)         :: 55 of 79
            Pseudo Genes (internal stop)      :: 4 of 79
            Pseudo Genes (multiple problems)  :: 10 of 79
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:35:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2833879
            Orig. end                         :: 2844728
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034669.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Gabriele M. Koenig,
            Institute for Pharmaceutical Biology, University of Bonn.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10849
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="11"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10849
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10849
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5849](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5849
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    670..685
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.52"
                     /tool="antismash"
     gene            1186..1710
                     /locus_tag="EJ065_RS12060"
                     /old_locus_tag="EJ065_2397"
     CDS             1186..1710
                     /EC_number="3.1.2.-"
                     /GO_function="GO:0047617 - fatty acyl-CoA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144: thioesterase superfamily protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395325.1"
                     /locus_tag="EJ065_RS12060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2397"
                     /product="PaaI family thioesterase"
                     /protein_id="WP_128796031.1"
                     /transl_table=11
                     /translation="MSEQAGNPRTRTVTWRDPREGASAAKKLSGLEYLRAIQRGELPAP
                     PIAELMGFSPVEVEEGRVVFAVKPGEHHYNPIGMVHGGLAATLMDSAMGCAIHTMLPVG
                     AGYTTLELHVNYVKGIAHDTGPLLCKGEVIHLGGRVATAQGRLVDEKGTLYAHGTTTCM
                     VFRPPGAGGKE"
     gene            1717..2319
                     /locus_tag="EJ065_RS12065"
                     /old_locus_tag="EJ065_2398"
     CDS             1717..2319
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015350982.1"
                     /locus_tag="EJ065_RS12065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2398"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_128796032.1"
                     /transl_table=11
                     /translation="MRYTAEHKQATHARILAAAEKLFRAEGFSGASVERVMRAAGLTVG
                     GFYAHFTSKESLLAESLRAFMTARRTPWLAGLEAARGTEFLGRFARRYLDQFDRDTGDT
                     TCMMPSLLSDLTRAAPEVQAAFAQGLEDLVGQAQTHLPAREGATPRQQMLATVTLCFGA
                     MTLARATASQPLAGEILDAARALLVAGAPVEERKKPL"
     gene            2403..3842
                     /locus_tag="EJ065_RS12070"
                     /old_locus_tag="EJ065_2399"
     CDS             2403..3842
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395327.1"
                     /locus_tag="EJ065_RS12070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2399"
                     /product="hypothetical protein"
                     /protein_id="WP_128796033.1"
                     /transl_table=11
                     /translation="MDARKTTVARAWLVGLALTLGACASVPLAPPWEDVPLRYDITYTH
                     DPSPRLNVEVVLPPSPPGVFPGAFLFRQPGRESSVVATFGDGSRTEIFPRNGVVRVPEG
                     ARILRYHYPLASSPREGGGHLFGGMGEGDTWHVGGKAYLLTPSRVTPELRVDLTVSGAD
                     ALLPWTPDASGVYHLRGEDLIDAGFHSFGGRRCQVHVGASVLEVALLGRFTHLTDADLR
                     AWLEQAGREVVTVRKAFPYPRVTVRVVPVPGEASPGVFGMTLWSSPPSISILVGQDATA
                     ASFSRDWVALHEMLHLTHPALVPRAAWLTEGLATYYTDLARARSGRQTAQQAWQELANG
                     FARGQVAARSRPMKEVVAEERNFMGIYWTGALFALHLDVELRRVTNGRARLEDVLELLA
                     TRGPTATLKSFGDAVDTVASQPLFDALLARHLPKPAFAELNPLLEDLGVRIDPGGVTLH
                     AAPGSGLREALDGERIPDDAG"
     gene            3937..4560
                     /locus_tag="EJ065_RS12075"
                     /old_locus_tag="EJ065_2400"
     CDS             3937..4560
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395328.1"
                     /locus_tag="EJ065_RS12075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2400"
                     /product="YceI family protein"
                     /protein_id="WP_128796034.1"
                     /transl_table=11
                     /translation="MFRSVLMLAATLSLSASAAEPAASDKHFVFHDPNSRDTVMFVLDA
                     PLEVINGLSNQVTGRVDVKGQKASGRFQVPVKSIKTGNETRDGHLQNDRWLDAAKHPDI
                     VFEFKDVALPAPLANAKPVVLKTKGTFTIHGITREEPVEVTATYLQETAETKNRAAGEL
                     LRVRAKFQIPLEAYGIQRTEALLLKVGERAEVTVDAWGSTQFKP"
     gene            4622..4888
                     /locus_tag="EJ065_RS12080"
                     /old_locus_tag="EJ065_2401"
     CDS             4622..4888
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395329.1"
                     /locus_tag="EJ065_RS12080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2401"
                     /product="hypothetical protein"
                     /protein_id="WP_128796035.1"
                     /transl_table=11
                     /translation="MNVKALAAVVGTLSLGALATGCASNKAAEGSKVHAASPGAAEGAE
                     ASCSNKPADAAAPAAAPAATPEKGAEGSCGAGSCGAGSCSGKK"
     misc_feature    4943..4957
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.58"
                     /tool="antismash"
     gene            5001..5849
                     /locus_tag="EJ065_RS12085"
                     /old_locus_tag="EJ065_2402"
     CDS             5001..5849
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395330.1"
                     /locus_tag="EJ065_RS12085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2402"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_128796036.1"
                     /sec_met_domain="DUF692 (E-value: 9.2e-97, bitscore: 322.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSPRYTDRHGLKPLGAGIGLRRDFYEALPRTPRALDWVEIIPEN
                     FLTLGGRSQRALDACRERWTLLPHGVGLNIGGPDALDDDYVTRLAALVKRLDAPFFSDH
                     LCYSRLGGVHLHDLLPLPFTEAAVEHVVPRVREVMARVERPFLLENPSYYAAMPGGTLK
                     EADFLRQVVEAADCGLLLDVNNVWVNARNHGYDPRAFVDALPLERVVQVHLAGHDVRET
                     VLIDTHGDRVCDDVWALYRYTLERTGPVSTLIEWDQAIPSLDAVLDEADRARAVLAEGA
                     R"
     gene            5846..6583
                     /locus_tag="EJ065_RS12090"
                     /old_locus_tag="EJ065_2403"
     CDS             5846..6583
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395331.1"
                     /locus_tag="EJ065_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2403"
                     /product="putative DNA-binding domain-containing protein"
                     /protein_id="WP_128796037.1"
                     /transl_table=11
                     /translation="MKASLKHFFDSMDAYLAGPPGAEGLLKLSASHPGWDVDPERMALY
                     GQFVRGHVRSTLEKLFPLTRKAVTPEAWDALVDGYTRTRPARHYELNRLGEGFAPFVAD
                     AAAAKGLPPFLPALARFEWTDFAVFASEEDLPDTVERLTPNPTLTVLEQPYRLCAFMRA
                     RGAEGVPAEGEELALLWRHPERLVTFYMEATPPALLVLKMAVEGLSEEAVVQATGMSAA
                     DLHAEVVRFAKDGLVLAPASRIH"
     gene            6716..7279
                     /locus_tag="EJ065_RS12095"
                     /old_locus_tag="EJ065_2404"
     CDS             6716..7279
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014395332.1"
                     /locus_tag="EJ065_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2404"
                     /product="chalcone isomerase family protein"
                     /protein_id="WP_128796038.1"
                     /transl_table=11
                     /translation="MKKTLTAVLLSLTLAAPVMAKDIAGVKYPDTATVAGKELKLNGVG
                     LRKKAIFKVYTLGLYVENPTQDATALLNADEVKRVRMFMKRDLKKDQITEAIENGFKKS
                     AGANMPKLQARLDAFKAAIPAEVKEGQELNLTYVPGKGTTVQVTGGQSIDVEGKDFADA
                     LFSVWLGKDPVDDDLKDAILGKDD"
     gene            7509..9644
                     /locus_tag="EJ065_RS12100"
                     /old_locus_tag="EJ065_2405"
     CDS             7509..9644
                     /EC_number="3.4.24.-"
                     /GO_function="GO:0008237 - metallopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012632590.1"
                     /locus_tag="EJ065_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2405"
                     /product="M13 family metallopeptidase"
                     /protein_id="WP_164933186.1"
                     /transl_table=11
                     /translation="MKRLALFAASCVLGAACKTAEPTPEPPQASAPAPVAAAAPATPAP
                     EAPAVPMSERPMPPGLDAAVMDPSVNPCDDFYQYACGGWLKATEIPAERARWSRGFETV
                     AERNQTVLRDILTQAAEGKGEGTPEEKKLGDFYGACMDEAKLEQSLPALRTHLAKLNGL
                     KSQQAVAGAVAWLHARDVNALFRVGSDQDQKDATQVIAVVDAGGLGLPDRDYYLKPDVK
                     MREARNAYQAHVQKVFELLGDAPFVASRKAIGILAIETRLANARLPKEERREPEKVYHR
                     LERQGLKKLAPAFQWDTYFAQVGLPAGEALNVTEPKFFSEVSALVRQQRPSDMGPYLSY
                     HLVKGVQTALPKALRDEFFRFESSVLTGAKADLARWKKCVDATDDALPHALAKPFIART
                     FGADGKATTLDMVQQIEQSFERNLDTLSWMDAETKAQALVKVKKITNKIGYPDQWRTYD
                     GLTVTRDSFLDNLLAADAFEQARQLRKVGQPVDRQEWFMSPPTVNAYYNAATNEIVFPA
                     GILQPPFFGRDASAAVNFGAMGMVVGHEITHGFDDEGRQFDADGNLRTWWTPASDKAFR
                     ERVSCVRNQYDQYTAVDDVKVNGKLTLGENVADLGGLKLAYAAMEAYLARHPDQAAKAN
                     SYRFTPGQQFFLAHAQSWCSKIRNEAARQRALTDSHSPAFLRVKGPDVNLPQFQQAFSC
                     PAGSPMVAPAANRCEVW"
     gene            9674..9922
                     /locus_tag="EJ065_RS12105"
                     /old_locus_tag="EJ065_2406"
     CDS             9674..9922
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013941499.1"
                     /locus_tag="EJ065_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_2406"
                     /product="GlsB/YeaQ/YmgE family stress response membrane
                     protein"
                     /protein_id="WP_120564099.1"
                     /transl_table=11
                     /translation="MGICSWLVLGGIAGWLASIIKGTNARMGMFANIFAGIVGAMLGGW
                     VFSFFGGRGVTGFNLYSLLVATVGAVILLSILQAIRK"
ORIGIN
        1 ggggggcagc acaccgcggg tgagggcgag gatgctgatg acggcctcgg cggcgccggc
       61 cgcgccgttc atgtggcccg tcatggactt ggtggaggag atggcgagcg acttcgccgc
      121 gtcgccgaac accttcgcga tgccctccat ctccagcagg tcgccgatgt ccgtcgaggt
      181 gccgtgggcg ttgaggtagc cgatgtccgc ggggttgagg cgcgcgttct tcagggaggc
      241 cttcatcgcg cgctgggcgc cctcgtggcc gggcgcgggc gaggtgacgt ggtaggcgtc
      301 ggagctggcg ccatagcccg tgagctccgc gaggatgcgg gcgccccggg cgcgggcgtg
      361 ctcgtactcc tccaggatga ggatggccgc gccctccgcg agcacgaagc cgtcgcggtc
      421 cttgtcgaac gggcggctgg ccgcctgggg cgcgtcgttg cggttggaca gggccttcat
      481 cgcggcgaag ccgcccacgc ccagcatgga gatgggggcc tccgcgccgc cggccagggc
      541 cacgtcgaac tcgccgcgct ggatgccgcg catcgcctcg ccaatggcgt gggcgctggt
      601 ggagcaggcg gagttggtgg accaggacgg gcccttgatg ccgtggcgca tggagatgta
      661 gccgggcgcc atgttgatga tcatctggag gatgaagaag gagctgatgc ggtccggccc
      721 cttctccagc gccctgcggt gcgtctcctc caggctgctg aggccgccga tgccggagcc
      781 gatgacggcc gccacgcgct ccgcgttctg ctcggtgatg accagcccgg agtcctcgag
      841 ggccatgtcc gacgcggcca ccgcgaactg cgcgaagcgg tccatgcggc gcacctcgcg
      901 ccgttcgacg tagtcctccg ggttgaagcc cttcacctca ccggcgaagc ggcagtccag
      961 cgcgctcgcg tcgaacaggg tgatgggcgc cacgccgctc cggccgttca ccagcgcgtc
     1021 ccagctcttc tccacgccga tgccacaagg gctgatgagc cccattcccg tcaccacgac
     1081 gcgccgctgt tccatcgcgc actccttggc cctgttcgtt gaaccgggat ggtattatgg
     1141 ccatccttcc atcagttcaa gcggttcaag cccaggggag ccccgatgag cgagcaggca
     1201 gggaatccgc gcacgcggac ggtgacgtgg agggacccga gggagggggc ctccgcggcg
     1261 aagaagctgt cggggctgga gtacctgcgc gccatccagc gcggggagct gccggcgccg
     1321 cccatcgcgg agctgatggg cttctctccg gtggaggtgg aggagggccg ggtggtgttc
     1381 gcggtgaagc cgggcgagca ccactacaac cccattggca tggtgcacgg cgggctggcc
     1441 gcgacgctga tggactccgc catggggtgc gccatccaca cgatgctgcc ggtgggcgcg
     1501 ggctacacga cgctggaact ccacgtgaac tacgtgaagg gcatcgcgca cgacacgggg
     1561 ccgctgctgt gcaagggcga ggtcatccac ctgggcggcc gcgtggcgac ggcgcagggc
     1621 cggttggtgg atgagaaggg cacgctctac gcgcacggca ccacgacgtg catggtgttc
     1681 cggccgccgg gcgcgggcgg caaggagtag gggcggatgc gctacaccgc tgaacacaag
     1741 caggccacgc acgcgcgcat cctcgctgcg gcggagaagc tgttccgcgc ggagggcttc
     1801 agcggcgcga gcgtggagcg ggtgatgcgg gccgcgggcc tgacggtggg cggcttctat
     1861 gcccacttca cctccaagga gtcgctgctc gcggagtcgc tgcgcgcctt catgacggcg
     1921 cgccggacgc cctggctcgc ggggctggag gcggcgcggg gcacggagtt cctggggcgc
     1981 ttcgcgcggc gctacctgga ccagttcgac cgggacacgg gcgatacgac ctgcatgatg
     2041 ccgtcgctcc tgtcggacct gacgcgcgcg gcgccggagg tgcaggccgc gttcgcacag
     2101 gggctggagg acctggtggg ccaggcccag acgcacctcc ccgcgcgcga gggcgccacg
     2161 ccccggcagc agatgctggc gacggtgacg ctgtgcttcg gcgcgatgac gctcgcgcgg
     2221 gccaccgcgt cgcagccgct ggcgggggag atattggacg cggcgcgggc gctgctcgtg
     2281 gcgggggctc cggtggagga gcggaagaag cccctctgag ccgacgtctc gttattccgg
     2341 gctggacggc atgggggccg ccgtggagtc cttccgcgcg gaccgcggac cgtgggggca
     2401 gggtggacgc aaggaagacg acggtggccc gcgcgtggct ggtgggactc gcgctcacgc
     2461 tgggggcgtg cgcctccgtg ccgctcgcgc ctccctggga ggacgtgccc ctccgctacg
     2521 acatcacgta cacgcatgac ccctcgccac gcctgaatgt ggaggtcgtc ctgccgccgt
     2581 cgcctccagg cgtcttccct ggcgcgttcc tcttccggca gccggggcgc gagagttccg
     2641 tggtcgcgac attcggggac gggagcagga ccgagatctt cccccggaac ggcgtggtgc
     2701 gggtgcccga aggagcgcgc atcctccgct atcactaccc gctggcctcc tctccccgag
     2761 agggcggcgg gcatctgttc gggggcatgg gggaaggaga cacgtggcac gtgggcggca
     2821 aggcctacct gctgaccccc agccgcgtga cacccgagct gcgcgtggac ctcaccgtgt
     2881 ccggcgcgga cgcgctgctg ccatggaccc cggatgccag cggcgtctac cacctgcgcg
     2941 gcgaggacct catcgacgcg ggcttccatt ccttcggagg caggcggtgc caggtgcacg
     3001 tgggcgcctc cgtgttggag gtcgcgctcc tgggccgctt cacgcacctc acggacgcgg
     3061 acctccgcgc gtggctcgaa caggccgggc gcgaggtcgt caccgtgcgc aaggcgttcc
     3121 cgtacccgcg cgtcaccgtg cgcgtcgtgc ccgtgcccgg tgaggcttcg cccggagtct
     3181 tcggcatgac cctgtggagc tcgccgccca gcatctccat cctcgtgggg caggacgcca
     3241 ccgccgcgtc cttctcccgt gactgggtcg cactccacga aatgctgcac ctcacgcacc
     3301 cggcgctggt gccccgggcg gcctggctca ccgagggact ggccacctac tacacggatc
     3361 tcgcccgcgc gcgctccgga cgccagacgg cccagcaggc ctggcaggag ctggcgaatg
     3421 gcttcgcgcg aggtcaggtc gccgcgcgct cacgccccat gaaggaggtg gtcgccgagg
     3481 agcggaactt catgggcatc tactggaccg gcgcgctctt cgcgctccac ctggacgtgg
     3541 agctgcgccg cgtgacgaac ggccgcgcac ggttggagga cgtgctggag ctgctcgcca
     3601 cacgcggccc caccgcgacg ctgaaaagtt ttggcgacgc cgtggacacg gtcgcgagcc
     3661 agccgctgtt cgacgcgctg ctcgcccgcc acctgccgaa gcccgccttc gctgaactga
     3721 atcccttgct ggaagacctg ggcgtccgaa ttgacccagg cggcgtcacg ctccatgctg
     3781 cgccgggcag tgggttgcgt gaggcgctgg acggcgagcg gatcccggac gacgcggggt
     3841 gaacacctgg agaagagaaa gggccgtaac cgattcccgg ttgtcgcgta tcgcatgcat
     3901 ccgcgaggtt cgcggcatcc gtagatgagg tccgccatgt tccgcagcgt cctgatgctc
     3961 gccgccaccc tgtcgctgtc cgcgtccgcc gcggagcccg cggcttccga caagcacttc
     4021 gtcttccatg atccgaacag ccgcgacacg gtgatgttcg tgctggacgc gccgctggag
     4081 gtcatcaacg gcctgtccaa ccaggtgacg ggccgcgtgg acgtgaaggg gcagaaggcc
     4141 agcggccgct tccaggtgcc ggtgaagtcc atcaagacgg gcaacgagac gcgcgacggc
     4201 cacctgcaga acgaccgctg gctggacgcg gcgaagcacc cggacatcgt cttcgagttc
     4261 aaggacgtgg ccctgcccgc gccgctcgcc aacgcgaagc cggtggtgct caagacgaag
     4321 ggcaccttca ccatccacgg catcacgcgc gaggagcccg tggaggtgac ggccacgtac
     4381 ctccaggaga cggccgagac gaagaaccgc gccgcgggcg agctcttgcg cgtgcgcgcg
     4441 aagttccaga ttcccctgga ggcctacggc atccagcgca ccgaagcgct gctgctgaag
     4501 gtgggcgagc gggccgaggt caccgtcgac gcctggggct ccacgcagtt caagccgtag
     4561 cggttgttgt cgtcagttcc ccccgtagtc acaccccacg cggtacgaaa ggaagcaaca
     4621 catgaacgtc aaggctcttg cggcggttgt cggcaccctg tccctcggcg cgctggccac
     4681 cggctgtgcg tccaacaagg cggcggaggg cagcaaggtg cacgccgcct cgccgggcgc
     4741 ggcggaaggc gccgaggcca gctgcagcaa caagcccgcc gacgccgcgg cccccgccgc
     4801 cgcccccgcc gcgaccccgg agaagggcgc cgagggctcc tgtggcgccg gctcctgcgg
     4861 cgctggttcc tgcagcggca agaagtagtc accgcatggg agggcctgcg tgacaggtct
     4921 cctcccaggc tcgcgggcgg cgggaagagt ccttcctgcc gcccgtgttg tttcacctgt
     4981 cgcacgtgaa ggagcgccgc atgccgtccc cccgctacac agaccgccat ggattgaagc
     5041 cgctgggggc gggcatcggg ttgcgccgcg acttctacga agcgctgccg cgcacgccgc
     5101 gcgcgctgga ctgggtggag atcatcccgg agaacttcct cacgctgggc ggccgctccc
     5161 agcgcgccct ggacgcgtgc cgcgagcgct ggacgctgct gccgcacggc gtgggcctca
     5221 acatcggcgg gccggacgcg ctggatgacg actacgtcac ccgcctggcc gcgctggtga
     5281 agcggctgga cgcgccgttc ttctcggatc acctgtgcta ctcgcggctg ggcggcgtgc
     5341 acctgcatga cctgttgccg ctgcccttca cggaggccgc ggtggagcac gtggtgccgc
     5401 gcgtgcgcga ggtcatggcg cgcgtggagc gccccttcct gctggagaac cccagctact
     5461 acgcggccat gccgggcggc acgctgaagg aggcggactt cctgcgccag gtggtggagg
     5521 ccgcggactg cgggctgctc ctggacgtga acaacgtctg ggtcaacgcg cgaaaccacg
     5581 gctacgaccc gcgcgccttc gtggacgcgc tgcccctgga gcgcgtggtg caggtgcacc
     5641 tggccggcca cgacgtgcgc gagacggtcc tcatcgacac gcacggcgac cgcgtctgcg
     5701 acgacgtctg ggcgctgtac cgctacacgc tggagcgcac cggcccggtg tccacgttga
     5761 ttgagtggga ccaggccatc ccgtcgctgg acgccgtgct ggacgaggcg gaccgggcgc
     5821 gcgccgtgct cgcggagggg gcgcgatgaa ggcgtcgctg aagcacttct tcgacagcat
     5881 ggacgcgtac ctcgcggggc cgcccggcgc ggaggggctg ttgaagctgt ccgcgtcgca
     5941 cccgggctgg gacgtggatc cggagcgcat ggcgctctac ggccagttcg tgcgcggcca
     6001 tgtgcgctcc acgctggaga agctcttccc gctgacgcgc aaggcggtga cgccggaagc
     6061 gtgggacgcg ctggtggacg gctacacccg cacgcggccc gcgcggcact acgagctcaa
     6121 ccgcctgggc gagggcttcg cgcccttcgt cgcggacgcc gccgccgcga agggactgcc
     6181 gccgttcctg cccgcgctcg cgcgcttcga gtggacggac ttcgcggtgt tcgcctccga
     6241 ggaggacctc ccggacaccg tggagcggct gacgcccaac cccacgctca cggtgctcga
     6301 gcagccctac cggctctgcg ccttcatgcg agcccggggc gcggaaggcg tgccggcgga
     6361 aggggaggaa ctggcgctgc tctggcgtca tccggagcgg ctggtgacct tctacatgga
     6421 ggccacgccg cccgcgctgc tggtgctgaa gatggccgtg gagggcctgt cggaagaggc
     6481 cgtcgtccag gccaccggca tgtccgccgc ggacctccac gcggaggtgg tgcgcttcgc
     6541 gaaggacggc ctggtgctgg cgccggcatc ccgcattcac tgaagaacct gttgtcttcc
     6601 gggcgcttcg ccgcggtacg tcaagacgcg gagggccttc gtggatcctt tcgtgaagac
     6661 gcatgggtag gtttgcgtcc aacatcgcgc agaaaccgac ccggaggttt tccccatgaa
     6721 gaagacgctg accgccgtgc tgctgtcgct gaccctcgcc gcgcccgtca tggccaagga
     6781 catcgcgggt gtgaagtacc cggacaccgc caccgtggcc ggcaaggagc tgaagctcaa
     6841 cggcgtgggc ctgcgcaaga aggccatctt caaggtctac acgctgggcc tctacgtgga
     6901 gaaccccacg caggacgcca ccgcgctgct caacgcggat gaagtgaagc gcgtgcgcat
     6961 gttcatgaag cgcgacctca agaaggatca gatcaccgag gccatcgaga acggcttcaa
     7021 gaagagcgcg ggcgcgaaca tgcccaagct ccaggcgcgc ctggacgcct tcaaggccgc
     7081 catccccgcg gaggtgaagg agggccagga gctcaacctc acctacgtgc cgggcaaggg
     7141 caccaccgtg caggtgacgg gcgggcagtc catcgacgtg gagggcaagg acttcgcgga
     7201 cgcgctcttc tccgtgtggc tgggcaagga ccccgtggac gacgacctca aggacgccat
     7261 cctcggcaag gacgactgac gcacccccac gcttcacccg gagtccttcg cgccccggaa
     7321 gcgccccctt cttcacgcaa ggggcgtttc gcggggcgcc gtcgtttccg gaggcagcgt
     7381 cattgcttca atggtggaca gcgcacgtcg cccctgtcac acgcgcatga gttgaagctg
     7441 gaatgccccc gcgcatcagg ggttgatgcg cgccggattc tcaccccttg tccgtgctgg
     7501 agaacgcttt gaagcgactg gccctcttcg ccgcctcctg tgtccttggc gccgcctgca
     7561 agacggcgga gcccaccccc gagccgcccc aggcctccgc cccggccccc gtggccgccg
     7621 ccgcgccggc cacgcccgcg cccgaggccc ccgccgtgcc catgtccgag cgccccatgc
     7681 ccccgggcct ggacgccgcg gtgatggacc catccgtgaa cccctgtgac gacttctacc
     7741 agtacgcgtg tggcggctgg ctgaaggcca cggagatccc cgccgagcgc gcgcgctgga
     7801 gccgcggctt cgaaaccgtg gccgagcgca accagaccgt gctgcgcgac atcctcaccc
     7861 aggccgcgga aggcaagggc gagggcaccc cggaagagaa gaagctgggg gacttctacg
     7921 gcgcctgcat ggacgaggcg aagctggagc agtcgctgcc cgcgctgcgc acgcacctgg
     7981 cgaagctcaa cgggctgaag agccagcagg cggtggccgg cgcggtggcc tggctgcacg
     8041 cgcgcgacgt gaacgcgctg ttccgcgtgg gctcggatca ggaccagaag gacgccacgc
     8101 aggtcatcgc cgtggtggac gccgggggcc tgggcctgcc ggaccgcgac tactacctca
     8161 agcccgacgt gaagatgcgc gaggcgcgca acgcctacca ggcgcacgtg cagaaggtgt
     8221 tcgagctgtt gggcgacgcg cccttcgtgg ccagccgcaa ggccattggc atcctcgcca
     8281 tcgagacgcg cctcgcgaac gcgcggctgc ccaaggagga gcggcgcgag ccggagaagg
     8341 tctaccaccg cctggagcgc cagggcctga agaagctggc gcccgcgttc cagtgggaca
     8401 cctacttcgc gcaggtgggg ctgcccgcgg gtgaagcgct caacgtgacg gagccgaagt
     8461 tcttctcgga ggtgtccgcg ctggtgcgcc agcagcgccc gtcggacatg gggccgtacc
     8521 tctcctacca cctggtgaag ggcgtgcaga cggcgctgcc caaggcgctg cgcgacgagt
     8581 tcttccgctt cgagtcctcg gtgctcaccg gcgccaaggc ggacctggcg cgctggaaga
     8641 agtgcgtgga cgccacggac gacgcgctgc cgcacgcgct ggccaagccc ttcatcgcgc
     8701 gcaccttcgg cgcggacggc aaggccacca cgctggacat ggtccagcag atcgagcagt
     8761 ccttcgagcg caacctggac acgctgtcct ggatggacgc ggagacgaag gcgcaggcgc
     8821 tggtgaaggt gaagaagatc accaacaaga ttggctaccc ggaccagtgg cgcacctacg
     8881 acgggctgac ggtgacgcgc gactcgttcc tggacaacct gctggcggcg gacgccttcg
     8941 aacaggcgcg ccagctgcgc aaggtgggcc agccggtgga ccgccaggag tggttcatgt
     9001 cgccgcccac ggtgaacgcc tactacaacg cggccaccaa cgagattgtc ttcccggcgg
     9061 gcatcctcca gccgccgttc ttcgggcggg acgcgtccgc ggcggtgaac ttcggcgcca
     9121 tgggcatggt ggtgggccac gaaatcaccc acggcttcga cgacgagggc cgccagttcg
     9181 acgcggacgg caacctgcgc acgtggtgga ccccggcgtc ggacaaggcc ttccgcgagc
     9241 gcgtgtcgtg cgtgcggaac cagtacgacc agtacaccgc cgtggacgac gtgaaggtga
     9301 acggcaagct caccctgggt gagaacgtgg cggacctggg cggcctcaag ctggcgtacg
     9361 cggccatgga ggcgtacctg gccaggcacc cggaccaggc ggcgaaggcg aactcgtacc
     9421 gcttcacccc ggggcagcag ttcttcctcg cgcacgcgca atcgtggtgc tcgaagattc
     9481 gtaacgaagc tgcgcggcag cgggcgctga cggattcgca ctcgccggcg ttcctgcgcg
     9541 tgaaggggcc ggacgtgaac ctgccgcagt tccagcaggc cttctcgtgc ccggcggggt
     9601 cgccgatggt ggcgcccgct gcgaaccgct gtgaggtctg gtaaggcttc ggccctacct
     9661 gtgggaggac ggcatgggaa tctgctcgtg gctggtgttg ggcggtatcg cgggctggct
     9721 ggccagcatc atcaagggca ccaacgcccg gatggggatg ttcgcgaaca tcttcgccgg
     9781 catcgtgggt gccatgctgg gcggctgggt gttcagcttc ttcggtggcc ggggcgtgac
     9841 aggcttcaac ctgtactcgc tgctggtggc gacggtgggc gcggtcatcc tgctgtccat
     9901 cctgcaagcc atccggaaat agcggtctcc ggaggtcgcg cccttcgctg cctagaagag
     9961 cgacagctgg ggtgaggtgg agggccgcgc ggggcgccgg aaggtgtccg gcgcggcctc
    10021 cgtgatggat gaggcgcgca tgcccacctt gcgcgccgcc gtcgcgaaga gctggtggat
    10081 ggtctgcgcg tagagccctt cgccgcgcat gcggtgcttg aagcggctgt cggtgagctc
    10141 cccgccgcgc gtctcgcgga tgcggtgcag cacccggtcc gcgcgcaggg gcagcttcgc
    10201 gcgcaggcgc tcctcgaaga cggcctgcac ggggccggga agccgcaaca gcgtgtagtg
    10261 cgcgcgcgtg gcgccggctt cacgcgcggt ggtgagcacg cgcgcgatgt cctcgtcgtt
    10321 gaggccgggg atgatggggg ccacggacac ggccacgtcg atgccggcct ccgtgagctt
    10381 gcggatggtg gccaggcgcc gcttgggtgt ggcgacgagc ggctccatgg cgcgcgccag
    10441 ctcctcgttg tggaagggga ggctgatgct cacgaacagc cgcgtctccg ccgccagccg
    10501 ctggagcacg tccaggtcgc gctcaatcag cacgcccttg gtgacgatgc ccacggggtt
    10561 gcggtactcg gcgcagacct ccaggcactg gcgggtgagc cggagcgacg cctccagggg
    10621 ctggtagcag tccgtgacgc cgctgaagac gaccgtctct cccttccacg acggacggtc
    10681 gaaggcttcg cgcaggagct ccggggcgtt gggtttgacg acgaggcgcg tctcgaagtc
    10741 ggtgcccgcg ccgaagtcca ggtactggtg cgtggggcgc gcgtagcagt aggcgcaggc
    10801 gtggaggcag ccccggtaag gattgacgct ccaggagaag cccacgtcg
//
