LOCUS       NZ_CP034669            11476 bp    DNA     circular CON 19-MAY-2024
DEFINITION  Corallococcus coralloides strain B035 chromosome, complete genome.
ACCESSION   NZ_CP034669
VERSION     NZ_CP034669.1
KEYWORDS    RefSeq.
SOURCE      Corallococcus coralloides
  ORGANISM  Corallococcus coralloides
            Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
            Myxococcaceae; Corallococcus.
REFERENCE   1  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Complete Genome Sequence of the Corallopyronin A producing
            Myxobacterium Corallococcus coralloides B035
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9587888)
  AUTHORS   Bouhired,S.M., Rupp,O., Blom,J., Schaeberle,T.F., Kehraus,S.,
            Schiefer,A., Pfarr,K., Goesmann,A., Hoerauf,A. and Koenig,G.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2018) Institute for Pharmaceutical Biology,
            University of Bonn, Nussallee 6, Bonn, NRW 53123, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 20-SEP-2017
            Assembly Method                   :: HGAP v. 4
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 350.5x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004104415.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:23:30
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,767
            CDSs (total)                      :: 7,695
            Genes (coding)                    :: 7,616
            CDSs (with protein)               :: 7,616
            Genes (RNA)                       :: 72
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 59
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 79
            CDSs (without protein)            :: 79
            Pseudo Genes (ambiguous residues) :: 0 of 79
            Pseudo Genes (frameshifted)       :: 30 of 79
            Pseudo Genes (incomplete)         :: 55 of 79
            Pseudo Genes (internal stop)      :: 4 of 79
            Pseudo Genes (multiple problems)  :: 10 of 79
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 23:35:23
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 268397
            Orig. end                         :: 279873
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034669.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Prof. Gabriele M. Koenig,
            Institute for Pharmaceutical Biology, University of Bonn.
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11476
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11476
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11476
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6476](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6476)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            97..891
                     /locus_tag="EJ065_RS01140"
                     /old_locus_tag="EJ065_0227"
     CDS             97..891
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393061.1"
                     /locus_tag="EJ065_RS01140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0227"
                     /product="hypothetical protein"
                     /protein_id="WP_128794280.1"
                     /transl_table=11
                     /translation="MSKANGTGVTKLFEDAHAEGILSPAGLQTLTVADLGAQIQAGLGI
                     HVDDVQASEVVLVTVMPDDSGSISHAGHTKTVCDGHNLVLDALLASQQKDGVLFHTRYL
                     NGHVLNPFRPLEDVVRMHSKNYSADMGTPLYDQAVVLLGTVLAKAQEFSGNGVPVRTVT
                     LLITDGADAGSQKARAKDVAALVKDLQRVENHIVAAMGIDDGVTDFRRVFQEMGISDRW
                     ILTPGQSAQEIRAAFQVFSQSAVRVSQGAASFSRTALGGFGA"
     gene            complement(902..1339)
                     /locus_tag="EJ065_RS01145"
                     /old_locus_tag="EJ065_0228"
     CDS             complement(902..1339)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393063.1"
                     /locus_tag="EJ065_RS01145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0228"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_128794281.1"
                     /transl_table=11
                     /translation="MTSISDETHQRITDLCAQGDTAAGDGNFEQALKHFKAALALIPEP
                     TRDHQQNTWVRAAIGDMYFQLERFEDCREHFREAVHSPGGLGNPFIHLRLGQSALELGD
                     EARAADELARAFMGGGEELFEGDDAKYLEFIQSRLLPPQDA"
     misc_feature    1646..1655
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            2072..2116
                     /locus_tag="EJ065_RS40950"
     CDS             2072..2116
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF026917.4"
                     /locus_tag="EJ065_RS40950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_346428672.1"
                     /transl_table=11
                     /translation="MHRVLEAAGLLRAL"
     gene            complement(2099..2866)
                     /locus_tag="EJ065_RS01155"
                     /old_locus_tag="EJ065_0230"
     CDS             complement(2099..2866)
                     /EC_number="3.5.1.-"
                     /GO_function="GO:0019213 - deacetylase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393065.1"
                     /locus_tag="EJ065_RS01155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0230"
                     /product="PIG-L family deacetylase"
                     /protein_id="WP_128794282.1"
                     /sec_met_domain="PIG-L (E-value: 2.4e-19, bitscore: 69.1,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTALFVSPHLDDVAFSCGGTLAALKAKGWTVALVTVFTRSVPKP
                     GGFALQCQTSKGLGPEVDYMALRRKEDRAFAACMGVDQVRWGDLEEAPHRGYESPEALF
                     QPPRADDVIEARVAKCLKPVLWDLKPDRVFVPQALGSHVDHVQVVRAVKGLGIPANRVL
                     YYRDTPYAVRQPMAHPDAAVPQGLRPLAVDITEHLPKKVEGCVRYGTQLGFQFGGVDGL
                     ARTLTAFHRMEAQGRGQPGAAEVFLAESSQGAQ"
     gene            complement(2863..4149)
                     /locus_tag="EJ065_RS01160"
                     /old_locus_tag="EJ065_0231"
     CDS             complement(2863..4149)
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393066.1"
                     /locus_tag="EJ065_RS01160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0231"
                     /product="glycosyltransferase family 4 protein"
                     /protein_id="WP_240672666.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 8.4e-31,
                     bitscore: 105.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNSVNGLRICFISRRFFPAISGMSVYALNLVRELVACGHDVTMVS
                     QYRSDPAGMAVYGGGPPPGIPGAHVLGCESVGEQRINQGQPASFEHDLEVMVDTVVREH
                     RRRPFDLIHAQYGYPCGLAALQAARLLGLPNVVSIQGGDGHWVGTCCGTHKQAMLAVLG
                     HAGALLIGSLSFAQEVSEHHGTPLERFTIVPGATDTQRFHPRSESALGETRDVPVWLYH
                     GRVDARKGVMELLDAVQRLMADGRTFKLRVSGIGPDVEAVRSRVATEGLQGVVELTGAS
                     TYAEAPDLYRSGDLFVSPTYSEGFSNTLLEAMASGLPIVSTRAVGVVDCLEDGRDALLV
                     PPKNSAALAEAMGRLMDDAPLRERLAATALREVRELYSWRAVGRRIQGVYRNLTGTRPD
                     TRWTRLYDPSMTEERADHTCRFRAEPHLL"
     gene            complement(4146..4997)
                     /locus_tag="EJ065_RS01165"
                     /old_locus_tag="EJ065_0232"
     CDS             complement(4146..4997)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002615746.1"
                     /locus_tag="EJ065_RS01165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0232"
                     /product="sugar phosphate isomerase/epimerase family
                     protein"
                     /protein_id="WP_128794284.1"
                     /transl_table=11
                     /translation="MALRFAYNTNGVSNHRFEDALGLIADSGYDGVALTLDHHHFDPFA
                     PDFERRTEQLAARLERLGLGLVVETGARFLLDPRRKHEPTLITPEAEGRARRREFLKRA
                     VDICATCRGEAVSFWAGVPRPGVTEKAAWPWLVDGVARLAEYAAVRGVVLAMEPEPGML
                     VETVDGWRRLQACVPGVRLALDVGHLLVTQERTPAEAVREFAQVLGTVALEDMKRGVHE
                     HLPFGEGDVDVPSVLRELTRAGYDRLVCVELSRDAHRAHELVPRALEWLRKRLPTGAEV
                     AA"
     gene            complement(5001..6476)
                     /locus_tag="EJ065_RS01170"
                     /old_locus_tag="EJ065_0233"
     CDS             complement(5001..6476)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393068.1"
                     /locus_tag="EJ065_RS01170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0233"
                     /product="YcaO-like family protein"
                     /protein_id="WP_128794285.1"
                     /sec_met_domain="YcaO (E-value: 5.5e-65, bitscore: 219.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIARAIDAYHHAVSTGALQLFRIDPIDRLGIPVASASLALGGGT
                     GAVLHGNGYGRTDEEARVGALGELVEETFCELAMHRMPRVHGSYAALVRARGPTAVADP
                     LTLGLPAGSPYQPDLPLVWVELQRLATGERVLVPEEYVAIHPGQLQGRTPLITPITNGQ
                     GAGLTRPQALAHGLLELIQRDGNGLRYRAMDQGVVVDMEGADLAPDVRELLELYRRAGV
                     EVMAKLASTDFGLVNLYVVGRDLSVGDQPLMVTACGEAADPDRDRALRKALLEYACSRA
                     RKAFMHGPLSHVARVAPPEYMDRFVPQVDLDAEEPRALNAMVEWARLPAQALRELTACT
                     LMVRKKVRFEDLPRSPTVEDPSLRCDHVVRQLHAAGLDILVADLSPPGRQVHVVKALVP
                     GLEVETMTYNRVGERNAARLLERRDPLVGLGAPPPGAQPVRLTPEAEERLGGPVWFNVR
                     LAEARVGRLYALYREPDRHAVPAVLASRRFGGQ"
     gene            complement(6473..7306)
                     /locus_tag="EJ065_RS01175"
                     /old_locus_tag="EJ065_0234"
     CDS             complement(6473..7306)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002615760.1"
                     /locus_tag="EJ065_RS01175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0234"
                     /product="hypothetical protein"
                     /protein_id="WP_128794286.1"
                     /transl_table=11
                     /translation="MPLTRYACTHCGTWQPGFPRERPTGCPTCLDVRNALPRDGWDFQT
                     AGQVSERLTTRWEETLPGIWGFTCTPTFGLGSTGWLLRRPEGNVCFEGAPWYSRPALEF
                     IDVMGGIHMLSASHPHGFGALWQLQEHFDPLLVLHRDAVPYSKAFQVRWPVDDEHALAT
                     DLTLHCVGGHYEGQMVLYDARTRSLFCGDALKVDLDAQGRPTGLSCHKGFHSAIPLSHG
                     ELRRYRAVLKQLPFENVFTSFEFARGVTRRHALALFDRLLSGMPHTLPLPLEELS"
     gene            complement(7297..8331)
                     /locus_tag="EJ065_RS01180"
                     /old_locus_tag="EJ065_0235"
     CDS             complement(7297..8331)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393070.1"
                     /locus_tag="EJ065_RS01180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0235"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_128794287.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 1.9e-26, bitscore:
                     91.9, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 1.4e-30,
                     bitscore: 104.6, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEAKPRARRLGWAVVGCGWVARDYVIPALQGASNARLVALCDAN
                     AEALMRIPADDVNRYTALGSVLADKDVQAVYIATPNHLHAAMTEACAAAGKHVLCEKPM
                     AVTPRDGLRMVSACQRAGVHYATAFDQRHHAAHRKLRTLVKEGVLGTVTQARIHYACWL
                     PADWAPDNWRIDPEQAGGGAMIDLAPHGLDLLEVVLGDEWESLTAMTQRRVHRYAVDDG
                     AVLLGQFKSGALGLLQVAYNCPDAYPRRTLELIGTRARALASKTMGQTPGGSLSLTDAK
                     TGEETWVPLSPEEDRSPFLHQVEVFSACVLEGRPQPFSPERDVRLVGLLTQATQSGKAF
                     PPCH"
     gene            complement(8354..9286)
                     /locus_tag="EJ065_RS01185"
                     /old_locus_tag="EJ065_0236"
     CDS             complement(8354..9286)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393071.1"
                     /locus_tag="EJ065_RS01185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0236"
                     /product="hypothetical protein"
                     /protein_id="WP_128794288.1"
                     /transl_table=11
                     /translation="MNAPARDTASPSRLAELRPLLSELMDLKRIRTPDHPDGLAAHGFR
                     RAWAALASGMEPRIVALRETARALAAVRLGGLDLDVLQRAGLSPLDATRVLHRGLEAVA
                     APLEPGLRERLTVALSQTPEEACHAPPPLFVERLVHQPRAGATFPGRPRILVSPQEGHA
                     DHCYAVAVGAVLVAPCFGASPALPFVAGLSHHLFNAALPDAGYGGEALLGDLLEPAMKR
                     LTERALSSLPERLAGVVRQALALTGNVDSAEARAFNAADALDRVLELEAHARAAGFTLR
                     QAMEDLELIHPGPLQTFGNDVLRDAAVWP"
     gene            complement(9290..10516)
                     /locus_tag="EJ065_RS01190"
                     /old_locus_tag="EJ065_0237"
     CDS             complement(9290..10516)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014393072.1"
                     /locus_tag="EJ065_RS01190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EJ065_0237"
                     /product="inositol-3-phosphate synthase"
                     /protein_id="WP_128794289.1"
                     /transl_table=11
                     /translation="MAGNERLGVAVVGLGGAVATTAVAGMELLRRGRVDTRGLPLAEAK
                     GLGLVEYGELTFGGWDLFEDDLAHAARNHAVLTEAQLEAVAPTLGRMRPWPAASNAKFC
                     KNVVGTAEKKARTLREQARALRDDLARFKQDQQLDRVVVVNLASTEKAVDLTRPEFATP
                     EAFEKALDANDPDIGPAMLYAYAAIVDGIPFANFTPSVAADVPALLLLAKRTGAPIAGK
                     DGKTGQTLLKTVLAPALRDRALHVDGWYSTNILGNRDGEALNDPASKQNKLDTKGAALD
                     SILGYKVQDHVVQIQYYRPRGDNKEAWDNIDVTGFLGQPMQLKLNFLCKDSILAAPLVV
                     ELARTLDLAKRRGECGVIDALGCFFKAPMSQDGEPVEHAMAEQQRRLMTWLSRGRGQQA
                     ERRPERIRG"
     misc_feature    complement(10743..10759)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
ORIGIN
        1 gcacctggtg aagtccacgg acccgctggc gagctggccg gacctgcacc tggcgtgacg
       61 tctggcattg gcactcacac gaagggagac acggacatga gcaaggcgaa cgggacgggt
      121 gtcacgaagc tcttcgagga cgcgcacgcg gagggcatcc tcagccccgc ggggttgcag
      181 acgctcacgg tggcggacct gggggcgcag atccaagcgg gcctgggcat ccacgtggac
      241 gacgtgcagg cgagcgaggt ggtgctggtg acggtgatgc cggatgactc cgggagcatc
      301 tcgcacgcgg ggcacacgaa gacggtgtgt gacgggcaca acctggtgct ggacgcgctg
      361 ctggcgagtc agcagaagga cggcgtcctg ttccacacgc gctacctgaa cggacacgtg
      421 ctcaatccgt tccggccgct ggaggacgtg gtgcggatgc actcgaagaa ctactcggcg
      481 gacatgggga cgccgctgta cgaccaggcg gtggtgctgc tgggcacggt gctggcgaag
      541 gcgcaggagt tcagcggcaa cggggtgccg gtgcgcacgg tgacgctgct gatcacggac
      601 ggcgcggacg cgggttccca gaaggcgcgg gcgaaggacg tggcggcgct ggtgaaggac
      661 ctgcagcggg tggagaacca catcgtcgcg gcgatgggca tcgacgatgg ggtgacggac
      721 ttccggcgcg tgttccagga gatgggcatc tcggaccggt ggatcctcac gcctgggcag
      781 agcgcccagg agatccgcgc cgcgttccag gtgttcagcc agtccgccgt gcgcgtcagc
      841 cagggcgcgg ccagcttcag ccgcacggcg ctgggcggct tcggagccta gctcgcggga
      901 ttcaggcgtc ctggggcggc agcaggcggg actggatgaa ctccaggtac ttcgcgtcgt
      961 cgccttcgaa gagctcctcg cctccgccca tgaaggcgcg ggccagctca tcggccgcgc
     1021 gggcttcgtc tcccagctcc agggcgctct gaccgagccg caggtggatg aagggattgc
     1081 cgagtcctcc cggcgagtgg acggcttcgc ggaagtgttc gcggcagtcc tcgaagcgct
     1141 cgagctggaa gtacatgtcg ccgatggcgg cgcgcaccca ggtgttctgc tgatggtcgc
     1201 gggtgggctc gggaatcagg gcgagggcgg ccttgaagtg tttcagggcc tgctcgaagt
     1261 tgccatcacc cgcggcggtg tctccctggg cgcagaggtc ggtgatgcgc tggtgggtct
     1321 catccgatat cgacgtcatc cgtgctccgg ggaccggggg aggatcgcgg tccgcggcac
     1381 agtgtagatg acctgtcgtg agttggagac gccgcgtggg cacgaaaccg tggggccggg
     1441 ctggctgctg gctgctgctg ctggtgttct gggtgggctg cgccagcgga cccacggtgc
     1501 ggctgcgcac ggagcggggg acccggacgt atgcgccggc cacgtgggac cgccgtgtgc
     1561 cggtcagtgc tcgggagttc gaggacgcgc tgacgcggct ggtgctggag gcgccactga
     1621 cggtgcgggc ggcgtgcggc gcgctgaagg cggccacgga cagggcgcag acgttccagg
     1681 agctggagga ggcggcggag gtcttcgcgc aggcactggg gccagaggtg gcgcgcgtgt
     1741 tcgtgctcgc ggtgacggtg ctggtgagtc acggcgtgac ggtggggctg tcatccgcgc
     1801 tctcgttgat gccgcgtttc ccggatgccg tgcggctggg ctcggcacag gcgggcttca
     1861 acccggcacg cgtgctggac gtgagcgcgg tggcggtagt ggacggcgtg gtggaggtga
     1921 cgctcgcgtc cacggcggtg gccatggccg cgatgggtcc gcctcctgcg agcagcgcag
     1981 gaggcccggg caaatgggtg caggtgaatg agtcgatgtc cgaccgtgcc cgcgactatc
     2041 gaacccggaa cacgtccggc tggccacgga ggtgcaccgg gttctcgaag cggccggtct
     2101 actgcgcgcc ttgtgatgac tccgccagga acacctccgc ggctcctggc tgaccccggc
     2161 cctgcgcttc catccggtgg aaggccgtga gcgtccgcgc caggccgtcc acgccgccga
     2221 actggaagcc cagctgcgtg ccgtagcgga cacagccctc caccttcttc ggcagatgct
     2281 ccgtgatgtc caccgccagc gggcgcaggc cctgcggcac ggcggcgtcg gggtgggcca
     2341 tcggctggcg cacggcgtac ggcgtgtccc ggtagtagag gacccggttc gccgggatgc
     2401 ccagcccctt cacggctcgc accacctgca cgtggtccac gtggctcccc agcgcctggg
     2461 gcacgaagac ccggtccggc ttcaggtccc acaacaccgg cttcagacac ttcgccactc
     2521 ttgcttcgat gacgtcgtcc gctcgcggtg gctggaacag cgcttccggg ctctcatagc
     2581 cccggtgcgg cgcctcctcc aggtctcccc accgcacctg gtccacgccc atgcaggccg
     2641 cgaaggcgcg gtcctccttc ctccgcaggg ccatgtagtc cacctccggc cccagcccct
     2701 ttgatgtctg acattgcagc gcgaagcccc ccggcttcgg caccgaccgc gtgaagacgg
     2761 tgacgagcgc caccgtccag cccttcgcct tcaacgccgc caacgtgccc ccacaggaga
     2821 aggccacgtc gtccaggtgc ggcgacacga acagggccgt gctcatagca ggtgcggctc
     2881 cgcccggaac cggcaggtgt ggtccgcgcg ctcctccgtc atcgaggggt cgtagaggcg
     2941 cgtccaccgc gtgtccggcc gcgtgcccgt caggttcctg taaacgcctt gaatcctccg
     3001 ccccaccgcc cgccacgagt acagctcccg cacctcgcgc agcgccgtgg ccgccaaccg
     3061 ctcgcgcagc ggcgcgtcgt ccatcagccg gcccatcgcc tccgccagcg cggcgctgtt
     3121 cttgggcggc accagcagcg catccctgcc gtcctcgagg cagtccacca cccccaccgc
     3181 tcgcgtcgac acgatgggca gtccggaggc catcgcctcc agcagcgtgt tggagaaccc
     3241 ctctgaatac gtgggcgaca cgaacaggtc cccgctccgg tacaggtccg gcgcctccgc
     3301 gtaggtggac gcccccgtca gctccaccac gccctggagt ccctccgtcg ccaccctcga
     3361 gcgcaccgcc tccacgtccg gcccaatccc agacacccgc agcttgaacg tccgcccgtc
     3421 cgccatcagc cgctgcacgg catccagcag ctccatcacc cctttccgag cgtccacccg
     3481 gccgtggtac agccacaccg gcacgtcccg cgtttctccc agcgccgact cactcctcgg
     3541 gtggaagcgc tgcgtgtccg tggcgccggg gacgatggtg aaccgctcca gcggggtccc
     3601 gtggtgctcg ctcacctctt gcgcgaagga caggctccca atcagcagcg cccccgcgtg
     3661 ccccagcacc gcgagcatcg cctgcttgtg cgtcccgcag caggtgccca cccagtgccc
     3721 gtccccgccc tggatggaga cgacgttggg caatcccagg agcctcgcgg cctgcagcgc
     3781 cgccaggccg cagggatagc cgtactgcgc atggatgagg tcgaacgggc ggcgccggtg
     3841 ctcgcgcacc accgtgtcca ccatcacctc caggtcgtgc tcgaagctcg cgggctggcc
     3901 ctggttgatg cgctgctcgc ccaccgactc gcagcccagc acgtgcgcgc ctgggatgcc
     3961 cggcggcggc ccgcccccgt acaccgccat gcccgcgggg tcgctgcggt actggctcac
     4021 catggtcacg tcgtgcccgc acgccaccag ctcccgcacc aggttcagcg catagacgct
     4081 catccccgag atggccggga agaagcgccg ggagatgaag cagatccgca gcccgttcac
     4141 gctgttcacg ccgccacctc cgcgcccgtc ggcaggcgct tcctcaacca ttccagcgcc
     4201 cggggcacca gctcgtgcgc ccggtgcgcg tcccgcgaca gctccacgca caccagccgg
     4261 tcgtagcccg cgcgcgtcag ctcgcgcagg accgacggca cgtccacgtc cccttcgcca
     4321 aacggcaggt gctcatgcac gccgcgcttc atgtcctcca gcgccaccgt gcccagcacc
     4381 tgcgcgaact cgcgcacggc ttccgcgggc gtgcgctcct gcgtcaccag caggtgcccc
     4441 acgtccaatg ccagacgcac gccgggcacg cacgcctgca accggcgcca gccgtccacc
     4501 gtctccacca gcatccccgg ctccggctcc atcgccagca ccacgccgcg caccgccgcg
     4561 tactccgcca gccgcgccac gccgtccacc agccacggcc acgcggcctt ctccgtcacg
     4621 cccggacggg gcactcccgc ccagaaggac accgcctccc cccggcacgt cgcgcagatg
     4681 tccaccgcgc gcttgaggaa ctcccgccgc cgtgcacggc cctccgcctc cggggtgatg
     4741 agcgtgggct cgtgcttcct ccgggggtcc agcaggaagc gcgcccccgt ctccaccacc
     4801 agccccaggc ccagccgctc cagcctcgcg gcgagctgct ccgtgcgccg ctcgaagtcc
     4861 ggcgcgaacg ggtcgaagtg gtggtggtcc agcgtcagcg ccacgccgtc gtagccactg
     4921 tccgcgatga ggcccagcgc gtcctcgaag cggtggttcg agacgccgtt ggtgttgtac
     4981 gcgaagcgca gggccatggc tcactgcccc ccgaagcggc ggctcgcgag caccgccggc
     5041 accgcgtggc ggtccggctc ccggtagagc gcgtacagcc tccccacgcg cgcctccgcc
     5101 agccgcacgt tgaaccagac ggggccgccc agccgctcct cggcctcggg cgtcagccgc
     5161 accggctgcg cgcccggcgg cggcgctccc aggcccacca gcggatccct gcgctccagg
     5221 agcctcgccg cgttgcgctc gcccacgcgg ttgtacgtca tcgtctccac ctccaggccc
     5281 ggcaccagcg ccttcaccac gtgcacctgg cggcccggcg gcgacaggtc cgcgaccagg
     5341 atgtccaagc ccgccgcgtg cagctgccgc accacgtggt cgcaccggag cgacgggtcc
     5401 tccacggtgg gcgagcgggg caggtcctcg aagcgcacct tctttcggac catcagcgtg
     5461 cacgctgtca gctcgcgcag cgcctgggcc ggcagccgcg cccactccac catcgcgttc
     5521 agcgcgcgcg gctcctccgc gtccaggtcc acctggggca cgaagcggtc catgtattcc
     5581 ggcggcgcca cccgggccac gtggctcagc ggcccgtgca tgaacgcctt gcgtgcccgc
     5641 gaacaggcgt actccagcag cgccttgcgc agcgcccggt cgcggtccgg gtcggccgcc
     5701 tctccgcacg ccgtcaccat cagcggctgg tcccccacgg acaggtcgcg gcccaccacg
     5761 tacaggttca ccaggccgaa gtccgtgctg gccagcttcg ccatcacctc cacgcccgcg
     5821 cggcgataga gctccaacag ctcgcgcacg tccggcgcca ggtccgcgcc ctccatgtcc
     5881 accaccacgc cctggtccat ggcgcggtac ctcagcccgt tgccgtcgcg ctggatgagc
     5941 tccagcaggc cgtgcgccag cgcctggggc cgcgtcagcc ccgcgccctg gccgttggtg
     6001 atgggcgtga tgagcggggt ccgcccctgc aactgtccgg ggtggatggc gacgtactcc
     6061 tccggcacca gcacccgctc gccggtggcc agccgctgca gctccaccca gacgagcggc
     6121 aggtccggtt gatacgggct gcccgcgggc agccccagcg tgagcggatc cgccaccgcg
     6181 gtggggcctc gcgcgcgcac cagcgccgcg tagctgccgt gcacgcgcgg catgcggtgc
     6241 atcgcgagct cgcagaaggt ctcctccacc agctctccca gcgcgcccac ccgcgcctct
     6301 tcgtccgtgc ggccgtagcc gttgccgtgc agcaccgcgc ccgtcccgcc ccccagcgcc
     6361 aggctggcgg aggccaccgg gatccccagc cggtcgatgg ggtcgatgcg gaacagctgc
     6421 agggcgccgg tggacacggc gtggtgatac gcgtcgatgg ctcgggcaat gctcatgaca
     6481 gttcctccaa gggcagggga agggtgtgcg gcatgcccga gagcagccgg tcgaacagcg
     6541 ccagcgcgtg ccggcgggtg acgccgcgcg cgaactcgaa cgaggtgaag acattctcga
     6601 acgggagctg cttgagcacg gcgcggtagc ggcgcagctc gccgtggctc agcggaatcg
     6661 cggagtggaa gcccttgtgg caggacaggc ccgtgggtct gccttgcgcg tccaggtcca
     6721 ccttcagcgc gtcgccgcag aacagcgaac gggtgcgcgc gtcgtacagc accatctggc
     6781 cctcgtagtg gccccccacg cagtgcagcg tcaggtccgt cgccagcgcg tgctcgtcat
     6841 ccaccggcca gcgcacctgg aaggccttgc tgtagggcac cgcgtcccgg tgcagcacga
     6901 gcagcgggtc gaagtgctcc tgcagctgcc agagcgctcc gaagccgtgc gggtgtgacg
     6961 cggacagcat gtggatgccg cccatcacgt cgatgaactc cagcgcgggc cgcgagtacc
     7021 agggcgcgcc ctcgaagcag acgttgccct ccggcctgcg cagcagccac cccgtggagc
     7081 ccaggccgaa ggtcggcgtg caggtgaagc cccagatgcc gggcagcgtc tcctcccagc
     7141 gcgtggtgag ccgctccgac acctggcccg ccgtctggaa gtcccagccg tcgcgcggca
     7201 gcgcgttgcg cacgtccagg caggtggggc agcccgtggg ccgctcgcga gggaagcccg
     7261 gctgccacgt gccgcagtgg gtgcaggcgt agcgggtcag tggcatggcg gaaacgcctt
     7321 tccagactgc gtcgcctgcg tcagcagccc caccagccgc acgtcgcgct ccggcgagaa
     7381 cggctgcgga cggccctcca gcacgcacgc ggagaagacc tccacctggt ggaggaaggg
     7441 gctccggtcc tcttccggcg agagggggac ccacgtctcc tctcccgtct tcgcgtcggt
     7501 gagcgacagg gagccgccgg gcgtctggcc catcgtcttg gacgccaacg ctcgcgcccg
     7561 ggtgccgatg agctccagcg tgcgccgggg gtacgcgtcc gggcagttgt aggccacctg
     7621 caacaggccc agcgcgccgc tcttgaactg gcccaacagc accgcgccgt catccacggc
     7681 gtagcggtgc acgcgccgct gcgtcatggc ggtgagcgac tcccactcgt cgcccagcac
     7741 cacctccagc aggtccaggc cgtgcggcgc caggtcgatc atcgcgccgc cgccggcctg
     7801 ctccgggtcg atgcgccagt tgtccggcgc ccagtccgcg ggcagccagc aggcgtagtg
     7861 gatgcgcgcc tgggtgacgg tgcccagcac gccctccttc accagcgtgc gtagcttgcg
     7921 gtgcgccgcg tggtggcgct ggtcgaacgc ggtggcgtag tgcacgcccg cgcgctggca
     7981 cgcggacacc atgcgcaggc cgtctcgcgg cgtgacggcc atgggcttct cgcacagcac
     8041 gtgcttgccc gcggcggcgc acgcctccgt catcgccgcg tgcaggtggt tgggcgtggc
     8101 gatgtagacg gcctgcacgt ccttgtccgc cagcaccgac cccagcgcgg tgtagcgatt
     8161 cacgtcgtcc gcggggatgc gcatcagcgc ctccgcgttc gcgtcgcaca gggccaccag
     8221 ccgcgcgttg ctcgcgccct ggagcgccgg gatgacgtag tccctcgcca cccagccaca
     8281 gcccaccacc gcccagccca gcctccgggc ccttggcttc gcctcgaaca tggtcaccgc
     8341 ctgttgggaa ggttcatggc cacaccgccg cgtcgcgcag gacgtcgttg ccgaacgtct
     8401 ggagcgggcc ggggtggatc agctccaggt cctccatcgc ctggcgcagg gtgaagcccg
     8461 ccgcgcgggc gtgggcctcc agctccagca cccggtccag cgcgtccgcg gcgttgaagg
     8521 cgcgcgcctc cgccgagtcc acgttgccgg tgagcgccag cgcctgccgc acgaccccgg
     8581 ccagccgctc cggcagcgac gacagggccc tctccgtgag gcgcttcatg gcgggctcca
     8641 gcaggtcccc cagcagcgcc tccccgccgt agcccgcgtc cggcagcgcc gcgttgaaga
     8701 ggtggtgcga gagccccgcc acgaagggca gggcggggga cgcgccgaag cagggcgcga
     8761 cgagcaccgc gcccaccgcc accgcgtagc agtggtccgc gtggccctcc tgcggcgaga
     8821 cgaggatgcg cggccggccg gggaacgtgg ccccggcgcg gggttgatgc accagccgct
     8881 ccacgaacag gggcggcggc gcgtgacacg cctcctccgg cgtctgggag agcgccacgg
     8941 tcagccgctc ccgcaggccg ggctccagcg gcgcggccac cgcctccagg ccccggtgaa
     9001 gcacccgcgt cgcgtccagc ggggacagcc ccgcccgctg gaggacgtcc aggtccaggc
     9061 cgcccagccg caccgccgcc agcgcgcgcg ccgtctcccg cagcgcgacg atgcgcggct
     9121 ccatgccgga ggccagcgcg gcccaggccc ggcggaagcc gtgcgccgcc agaccgtccg
     9181 ggtggtccgg ggtgcggatg cgcttgaggt ccatcagctc cgacaggagc gggcggagct
     9241 ccgccagacg gctcggggac gccgtgtcac gcgcgggtgc gttcatggct cagcccctga
     9301 tgcgttccgg gcggcgctcc gcctgctgcc cgcggcccct ggaaagccac gtcatcagcc
     9361 ggcgctgctg ctccgccatg gcgtgctcca cgggttcgcc gtcttgcgac atgggggcct
     9421 tgaagaagca gcccagcgcg tcgatgacgc cgcactcacc ccggcgcttc gccaggtcca
     9481 gcgtgcgcgc cagctccacg acgagcggcg cggcgaggat ggagtccttg cagaggaagt
     9541 tgagcttcag ctgcatgggc tggcccagga agcccgtcac gtcgatgttg tcccaggcct
     9601 ccttgttgtc ccctcgcggg cggtagtact ggatttgaac gacgtggtcc tggaccttgt
     9661 agccaaggat gctgtccagc gcggcgccct tggtgtcgag cttgttctgc ttcgacgccg
     9721 ggtcgttgag ggcctctccg tcgcggttgc ccaggatgtt ggtggagtac cagccgtcca
     9781 cgtgcagcgc gcggtcgcgc agcgcgggcg cgagcaccgt cttgagcagc gtctgccccg
     9841 tcttgccgtc cttgcccgcg atgggcgcgc cggtgcgctt cgccagcagc agcagcgcgg
     9901 gcacgtccgc ggcgacgctg ggcgtgaagt tggcgaacgg gatgccgtcc acgatggccg
     9961 cgtacgcgta gagcatcgcg gggccgatgt ccgggtcgtt cgcgtccagg gccttctcga
    10021 aggcctccgg cgtggcgaac tccggacggg tgaggtccac ggccttctcc gtggaggcca
    10081 ggttcaccac caccacgcgg tccagctgct ggtcctgctt gaagcgggcc aggtcgtcgc
    10141 ggagggcccg cgcctgttcg cgcagggtgc gcgccttctt ctccgcggtg cccacgacgt
    10201 tcttgcagaa cttcgcgttg gaggccgcgg gccacggccg catgcggccc agcgtgggcg
    10261 ccaccgcctc cagctgcgcc tccgtcagca cggcgtggtt gcgcgccgcg tgcgccaggt
    10321 cgtcctcgaa caggtcccag ccgccaaagg tcagctcgcc atactccacc agccccaggc
    10381 ccttcgcctc cgccaggggc aggccccgcg tgtccacccg tccccggcgc aggagctcca
    10441 tgcccgctac cgccgtggtc gccaccgcgc cgcccagtcc caccaccgcc acgcccaacc
    10501 gctcgttgcc cgccatgtgt gatgcccctc cccgtccgtt gtgccccgtg ctctcgcggc
    10561 gacacttcgg cggcgccccg gggtgacagg agccccgtgg atggaggcgc ttcttgcgcc
    10621 cgctcgctgc gagagttcgt ggaaggtcgg cacctgcccg ggggctttca actcagcccc
    10681 tggaccgtgc ggactgtccg ctggcggagg gcggcctcag acgtgccgca gcttccagcc
    10741 gccgcgccgg aagagggcgg cgctcgccag gccgagcgct ccatacgtga cggcgatggc
    10801 gatgaacgcg cccgagggac ccaggcccaa aggatgggag aggacccacg cgagcggcag
    10861 ctggaggccc caggagaaca gggcgttcac cacggtgggg gtggtggtgt cgcccgcgcc
    10921 gttgaaggcg tggggcagca cggtgacgaa ggcgtagagg gccaggctgc agctgacgat
    10981 gcgcaggcag cgcacggcgt gcatgcccac ctccggctcg gtggtgaagc ggtggatgag
    11041 cggctccgcg aagagcagga agcccaccgc caccacgccc aggaacgcga gcgtgtagaa
    11101 gctggcccgc cacgcggccc gctccgcgcg gtcggtgtcg cccgcgccca ggctctggcc
    11161 caccagcgtg cccgccgcgt gggacaggcc ccatgacggc tgctgcgcga agagcaggac
    11221 gcgcatggcc agcgtgtagc ccgcgagcgc ggtgctgccg aaggtggcca cgatgcgcat
    11281 caacaccagc cagctggaca tgcccagcag cgactggagc gtggcgcctc ccgacagctt
    11341 cagcagcgag cgcagcgtgg acgcctccac gcgcaggtgg cggcggcgca attccagacg
    11401 tccgttgccc ttgagcaggc gatacacctg atacagcacg ccggtggagc ggcccacggt
    11461 ggtggccagc gcggcg
//
