LOCUS       NZ_RQJW01000008        22546 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces cyaneus strain CGMCC 4.1671 Scaffold7_1, whole genome
            shotgun sequence.
ACCESSION   NZ_RQJW01000008
VERSION     NZ_RQJW01000008.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces cyaneus
  ORGANISM  Streptomyces cyaneus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 474995)
  AUTHORS   Fang,B.-Z., Han,M.-X., Jiao,J.-Y., Xie,Y.-G., Zhang,X.-T., Liu,L.,
            Zhang,Z.-T., Xiao,M. and Li,W.-J.
  TITLE     Streptomyces sp. nov., a novel actinobacterium isolated from a karst
            cave sample
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 474995)
  AUTHORS   Fang,B.-Z., Han,M.-X., Jiao,J.-Y., Xie,Y.-G., Zhang,X.-T., Liu,L.,
            Zhang,Z.-T., Xiao,M. and Li,W.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2018) School of Life Sciences, Sun Yat-sen
            University, No. 135 Xingang West Road, Guangzhou, Guangdong 510275,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-OCT-2018
            Assembly Method                   :: SPAdes v. 3.6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004028635.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 03:28:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,717
            CDSs (total)                      :: 8,635
            Genes (coding)                    :: 8,413
            CDSs (with protein)               :: 8,413
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 222
            CDSs (without protein)            :: 222
            Pseudo Genes (ambiguous residues) :: 0 of 222
            Pseudo Genes (frameshifted)       :: 77 of 222
            Pseudo Genes (incomplete)         :: 187 of 222
            Pseudo Genes (internal stop)      :: 12 of 222
            Pseudo Genes (multiple problems)  :: 50 of 222
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:58:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 125682
            Orig. end                         :: 148228
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RQJW01000008.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22546
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22546
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22546
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12546](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12546)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(377..392)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.7"
                     /tool="antismash"
     misc_feature    656..671
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.55"
                     /tool="antismash"
     gene            complement(952..2520)
                     /locus_tag="EHO50_RS28910"
     CDS             complement(952..2520)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (83-284). E-value:
                     1.2e-09. Score: 30.1. Matches aSDomain:
                     nrpspksdomains_EHO50_RS28910_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119073.1"
                     /locus_tag="EHO50_RS28910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_128434155.1"
                     /sec_met_domain="PF00561 (E-value: 1e-07, bitscore: 26.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_S9 (E-value: 1.4e-06, bitscore:
                     22.6, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGHHRKALRTTAVGAVSATLIAGSALGLAPAAGAATNSVRFVDIS
                     GDGGTTLKANVITPAGADGSRRFPLLVLPTSWGLPQVEYFAQAQKLANSGYVVVSYNVR
                     GFWQSGGEIEVAGPPDIADASRVIDWALANTPADAGHIGMAGVSYGAGISLLTAAHDKR
                     VKAVAALSGWADLIGSIYSGRTQHVQAAALLDGASLVTGRQSAEVRQIFNDFYASNLSK
                     EQDMINWGKKRSVATYVDQLNNNGAAVMMANAWGDTIFPPNQYADFYEKLTGPKRLEFR
                     PGDHATAELTGLFGLPNDVWTDTERWFDHHLKGEDNGINRELPVQLKSRSAGGYEGYPD
                     WKSVGATNKKIALGGTTTIHTNVNSGADGGVVFLSSILDQVAQLPPVASIPLIPRRWAG
                     VWQSEKYATPQHVRGTAKLHTTLTPTKESGTLVAYLYDVGPLGLGKLVSNAPYTFHGRT
                     PGKPFAVDLELYSTAYDVPAGHRLALVVDTVDPLYIEHNPTGARLTFSSPANDPSYVSI
                     PLREQ"
     aSDomain        complement(1669..2271)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EHO50_RS28910_Abhydrolase_1.1"
                     /evalue="1.20E-09"
                     /label="EHO50_RS28910_Abhydrolase_1.1"
                     /locus_tag="EHO50_RS28910"
                     /protein_end="284"
                     /protein_start="83"
                     /score="30.1"
                     /tool="antismash"
                     /translation="YFAQAQKLANSGYVVVSYNVRGFWQSGGEIEVAGPPDIADASRVI
                     DWALANTPADAGHIGMAGVSYGAGISLLTAAHDKRVKAVAALSGWADLIGSIYSGRTQH
                     VQAAALLDGASLVTGRQSAEVRQIFNDFYASNLSKEQDMINWGKKRSVATYVDQLNNNG
                     AAVMMANAWGDTIFPPNQYADFYEKLTGPKRLEFRPGD"
     misc_feature    2544..2554
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    complement(2550..2565)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.68"
                     /tool="antismash"
     misc_feature    2597..2614
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.14"
                     /tool="antismash"
     misc_feature    complement(2599..2616)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.11"
                     /tool="antismash"
     gene            complement(2637..3395)
                     /locus_tag="EHO50_RS28915"
     CDS             complement(2637..3395)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431788.1"
                     /locus_tag="EHO50_RS28915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_181449710.1"
                     /transl_table=11
                     /translation="MNDDVRNIVLGVVAAGISAGLGWLARTYLWKRKLRRKQAFFGLPE
                     NAESLLVVNRGAGGPELTVMRYDVFALLELAALIKDCNAHAQIVPHDAARQGFGERTEF
                     CVGGPASNRRMMAHLASLLPGVRVNVDAEPGPDRGALQVGSERYRVEVGKEEYALLARL
                     TVGQSHGTRPVFLFCGQTAITNQAATRYLARNHERLTRKHGTGSFVLLLKVVNSQAYGP
                     DVVELVADVTRAAQAPLPTPAAPRNTHRTS"
     misc_feature    complement(3421..3434)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    3421..3434
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 18.31"
                     /tool="antismash"
     gene            3513..5312
                     /gene="ggt"
                     /locus_tag="EHO50_RS28920"
     CDS             3513..5312
                     /EC_number="2.3.2.2"
                     /GO_process="GO:0006750 - glutathione biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ggt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1274: gamma-glutamyltranspeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385778.1"
                     /locus_tag="EHO50_RS28920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gamma-glutamyltransferase"
                     /protein_id="WP_181449711.1"
                     /transl_table=11
                     /translation="MRRPVARKLSVLAVSAAVVSVGAAAPPAAQSGPAAKVPVAVGYGG
                     AVSSVDADASAAGIEVLRKGGNAVDAAVATAAALGVTEPYSAGIGGGGYFVYYDAKSRT
                     VQTIDGRETAPLTADSDLFVENGTAIPFAEAVSSGLSVGTPGTPATWQKALDKWGSKGL
                     GTLLGPAERLARDGFTVDDTFRAQTAANETRFRYFPDTAKLFLPNGQLPVVGATFKNPD
                     LARTYAELAKRGVGALYRGDIAEDIVDTVNHPPVDPGSGWKARPGDLTAKDLAGYRTKS
                     QAPTRTSYRGLGVYSMAPSSSGGTTVGEALNILENTDLSKASEVQYLHRYIEASRIAFA
                     DRGRWVGDPAFEDVPTKELLSQKYADSRECLIKDDAVLTSPVAPGDPRNPAACDASGTP
                     APTTYEGDSTTHLTVADKWGNVVSYTLTIEQTGGSGITVPGRGFILNNELTDFSFTPAS
                     AAVHDPNLPGPGKRPRSSMSPTIVLDRHNKPVVALGSPGGATIITTVLQTLTGFLDRGL
                     PLVDAIAAPRASQRNQTTTELEPGLWSSPLKGRLEAIGHGFRQNAEIGAATGVQRLPDG
                     KWLAAAETVRRGGGSAMVVRPAP"
     gene            complement(5334..7889)
                     /locus_tag="EHO50_RS28925"
     CDS             complement(5334..7889)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1223: ATPase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996640.1"
                     /locus_tag="EHO50_RS28925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-dependent Clp protease ATP-binding subunit"
                     /protein_id="WP_128434156.1"
                     /transl_table=11
                     /translation="MTSGFNGGPEDYDPFGEFLARFFGGPRPGPRQIDIGRLLSQPARE
                     LVRGAAQYAAEHGSRDLDTQHLLRAALSAEPTRSLLSRAGADPDSLATEIDERSGPVQH
                     PPGEAPPPTSLSLTPAAKRALLDAHDLARARGAGYIGPEHVLSALAANPDSAAGHILNA
                     ARFAPSGGPSEASDAPDSRPRIDQRPRVDTGTPTLDKYGRDLTDLARRGRIDPVIGRDE
                     EIEQTIEVLSRRGKNNPVLIGDAGVGKTAIVEGLAQRIADSDVPDVLSGRRVIALDLTG
                     VVAGTRYRGDFEERLNNIVGEIRSHSDQLIVFIDELHTVVGAGGGGEGGSMDAGNILKP
                     ALARGELHIVGATTLEEYRRIEKDAALSRRFQPILVPEPTTADAIEILRGLRDRYEAHH
                     QVRYTDEALVAAVELSDRYLTDRRLPDKAIDLIDQAGARVRLHARTKGTDVRAMEREVE
                     QLYRDKDQAVADESYEQATQLRDRIVELKQRMADAAGDEEVDEGQHLEVTAEAIAEVVS
                     RQTGIPVSSLTEEEKDKLLGLEEHLHERVVGQDEAVRVVSDAVLRSRAGLASPDRPIGS
                     FLFLGPTGVGKTELARALSEALFGSEERMVRLDMSEYQERHTVSRLIGAPPGYVGHEEA
                     GQLTEVVRRHPYSLLLLDEVEKAHPDVFNILLQVLDDGRLTDSQGRTVDFTNTVIVMTS
                     NLGSEAISRGGTGIGFGAGGEEADEEARRERILRPLREHFRPEFLNRIDEIVVFRQLTH
                     DQLERITNLLLDQTRRLLRAQGVSVDFTGTAVDWLSERGYQPEYGARPLRRTIQKEVDN
                     QLSRLLLDGRIGEGGRVTVDVQDGRLAFRTEELPPAPEL"
     gene            complement(8124..9899)
                     /locus_tag="EHO50_RS28930"
     CDS             complement(8124..9899)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988508.1"
                     /locus_tag="EHO50_RS28930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_246101576.1"
                     /transl_table=11
                     /translation="MATLYGLTAGHRTAVAVATALTLAGSALGLAQPLVARHAVDASAR
                     GQVVWPLLALLGALFLVEAAIGSAGRFLLERMGEGVVRQLRVGLVGRLLRLEMREYDRH
                     RNGDLISRVTADTTLLREVVSQALVDLVTGTLVAAGAVILMAWLDPLLLLLVALTVAVA
                     AAVVTSLLQGLRKASERMQDSVGAVAADLERALGALPMVRVHRAEDREAARIGRRVEEA
                     YDAGVRTAKLASVMSPAVELAVQGSFLIVLVVGGLRISGHAGSLGDLVAFLLYASYLVL
                     PLSSVFHAVGLIQRGMGAYRRVDQALRLPVEHTGPAVEQARPRPRPVPSVPADRPALAL
                     HDVRFGYAPGRPVLSGVSFAVPHHRHVALVGPSGAGKSTVFALVAGFYEPDAGTVLFDG
                     RPAAELGRDACRRRIAVVDQNTHVVHGTLRENITYAVPDAPESEVRRVLELARLEELVD
                     RLPGGLDAVIGERGGTLSGGERQRVALARALLARPALLLLDEPTSHLDAINEAALTTVM
                     KEIAQECALLVIAHRLSTVQHADHIVVLHEGRSAACGRHEDLLTRDPLYRDLATSQMLR
                     PGGPSADPDGRRANG"
     gene            complement(10001..10426)
                     /locus_tag="EHO50_RS28935"
     CDS             complement(10001..10426)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602541.1"
                     /locus_tag="EHO50_RS28935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_128434158.1"
                     /sec_met_domain="PF13471 (E-value: 1.9e-26, bitscore: 87.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALERPTGVPLGHRLAALLVLLPAVALALLPPRRIRTVLGV
                     VRRGAAPATTTQAQDARDAMCAASLRCAGPKGCLPRSLGAALLCRLRGTWPTWCTGVRV
                     VPPFTAHAWIEAEGRPVGEGVPDGYFARLVAVEPADL"
     gene            complement(10423..10677)
                     /locus_tag="EHO50_RS28940"
     CDS             complement(10423..10677)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988506.1"
                     /locus_tag="EHO50_RS28940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_128434159.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 5e-25,
                     bitscore: 82.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2e-17, bitscore: 58.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLRFDAHISTAETDYGTVLLDERAGTYWELNPTATLVVRTLLDG
                     GEEADATAALIRDFDIDRAQAQRDVEALVGQLREAGLAS"
     aSDomain        complement(10429..10671)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EHO50_RS28940_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.30E-26"
                     /identifier="RREFam002.1"
                     /label="EHO50_RS28940"
                     /locus_tag="EHO50_RS28940"
                     /protein_end="83"
                     /protein_start="2"
                     /score="82.1"
                     /tool="antismash"
                     /translation="LRFDAHISTAETDYGTVLLDERAGTYWELNPTATLVVRTLLDGGE
                     EADATAALIRDFDIDRAQAQRDVEALVGQLREAGLA"
     misc_feature    complement(10667..10680)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.04"
                     /tool="antismash"
     gene            complement(10702..12546)
                     /locus_tag="EHO50_RS28945"
     CDS             complement(10702..12546)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003988505.1"
                     /locus_tag="EHO50_RS28945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_128434160.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.5e-46, bitscore:
                     154.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELHESAGTGPGDAHFAVFPDRADAAAVARSFARPGSRTLAHAS
                     GRPWLVGHWHDDEIVTASAGSATLAVIGCCPVEAAQLRRTAARLRDLTELDAPARTLPG
                     SFHLVAALDGQIRVQGTASGLRLVFHAEIDGVRVAATRADTLAAALGLDPDPQELAVRL
                     LWPAPYPLFETSLWRPVTAVPPQDAVIVAADGRTVRHTRWWTPPEPVRPLAEAAPLIRT
                     ALEEAVGARTRQGGVVSCDLSGGLDSTSICFLADRSPAHVVASTWPGRDPADTDLHWAQ
                     RAMGHLPDVEHVVWDADASPLVYEDLLGIDDLLDEPTIGVMDRSRVLHHLPGLAARGSR
                     VHLTGIGGDHVAWCSDAYYHRLLRTRPLFALRQLRGYRALWQWPLGGTALALADSRPYG
                     KWLADGAGRLRGPLPSSVATSLGWGMAPRLFDWVTPEAERMARRALLDAAATASPLHPD
                     RGLHTDLEQIRSCTRVIRQWDRMAARAGLPMASPFFDDRVIEAFLAVRPSERVTPWQYK
                     PVLSAAMRGIVPDDCLRRANKATAAMDAANGLRRHRGDLLTMWEGSRLEALGLVDGAEL
                     RRLAQRPTSPGLSDAILYSTIAAEVWLRGLSHSRARTP"
     gene            complement(12572..12682)
                     /locus_tag="EHO50_RS28955"
     CDS             complement(12572..12682)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638602.1"
                     /locus_tag="EHO50_RS28955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_128434161.1"
                     /transl_table=11
                     /translation="MKKAYEAPTLVRLGTFRKETGLLQSSGNDRLIFSKN"
     misc_feature    12883..12896
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 20.7"
                     /tool="antismash"
     misc_feature    12928..12944
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.34"
                     /tool="antismash"
     gene            complement(13023..13799)
                     /gene="map"
                     /locus_tag="EHO50_RS28960"
     CDS             complement(13023..13799)
                     /EC_number="3.4.11.18"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="map"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972570.1"
                     /locus_tag="EHO50_RS28960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type I methionyl aminopeptidase"
                     /protein_id="WP_128434162.1"
                     /transl_table=11
                     /translation="MVELKTDTSIDEMYAAGQVVGQALTAVRKAADVGVSLLELDEVAR
                     EVLRAAGATSPFLGYRPSFAPVPFPAVICASVNDAIVHGIPTGYRLCDGDLVSIDCGAE
                     LGGWAGDSAISFTVGGARPADVRLIETAERALAAGIDAAVVGNHIGDIAHAIGSVCRAA
                     GYGIPDGFGGHGIGRKMHEDPGVPNEGRPGRGMPLRHGMVLAIEPMLIASGKDGYHAAP
                     DGWTLRTNDGSRAAHVEHTVAITDAGPRILTAREAL"
     misc_feature    complement(13799..13812)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.86"
                     /tool="antismash"
     gene            13864..14124
                     /locus_tag="EHO50_RS28965"
     CDS             13864..14124
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007501168.1"
                     /locus_tag="EHO50_RS28965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_128434163.1"
                     /transl_table=11
                     /translation="MVRTPLTPEERERGERLGRLLREARGGRSMAEIAANAGVSAETLR
                     KIETGRAPTPAFFTVAALAHALGLSMDELAGRCTPVVEAAA"
     misc_feature    14168..14182
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.48"
                     /tool="antismash"
     misc_feature    complement(14187..14204)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.75"
                     /tool="antismash"
     gene            14257..16329
                     /locus_tag="EHO50_RS28970"
     CDS             14257..16329
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133398.1"
                     /locus_tag="EHO50_RS28970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_128434164.1"
                     /transl_table=11
                     /translation="MSVDQLPARVREFVNYLDGLLARLDQGGGWCGVFWQRDPEGMQAC
                     LDGREVPPWDVVESLLHDLGAQYGPGGAGPETERARALHAAALAVYDSRPGGRDALGDR
                     LDVMLREQRYAAERQADLGRSLAAATSQEAADAIRLDLAWARDDHERATARCAELRARM
                     ADLDRRAASERGQAIRRDRVGEGSVFRVDEGLRGDRSGGEGPRADRFENDGLRGERARG
                     SRFGGDRFGADGSGESRSGDDTVGGDAFGGDGFGDSGGGADRRQSGAIGSRGGGFPGMP
                     HQRDARPTPRTAGWSEGRGAAPAGTAADRHDGRRAATSAAEAAQWRAARQRGFDAGSAG
                     GHDSVHAGTEGHDAVHGQGADPYAGRGTAGPPDWPDPQGTGAGADRPTGHPLDRTAPDG
                     ATAPSDWPEAEHTPADTASAAATFDAAPVPAAPDPTPTPKQRKRRRGSARFAGMVEEEA
                     APVVVPPTAAPTLPTLPTLPAQPARTGRTPRGARFAGAAAETPAHTAPQPKREPMDPAD
                     RREVVGTVETLVRLRGEGRTGEAHVLLVEAAYWPAVRFPLLAAEMQRAGLGADWATLLW
                     EAASLPAERLVAAADALTVAGRADDGEQILRQGVARPAHEIGQAVVGLVGEGRHREVRA
                     LLDAYVRVRTPEEAARSAEPAPKTLVPLLLEAARGVSDERHWDLVHALRVAGFTA"
     gene            16510..17352
                     /locus_tag="EHO50_RS28975"
     CDS             16510..17352
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999657.1"
                     /locus_tag="EHO50_RS28975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_128434165.1"
                     /transl_table=11
                     /translation="MANVVRAALVQATWTGDTESMVAKHEEHAREAARQGAKIIGFQEV
                     FNAPYFCQVQEPEHYRWAEPVPDGPTVRRMQELARETGMVVVVPVFEVEQSGFYYNTAA
                     VIDADGTFLGKYRKHHIPQVKGFWEKYYFKPGNVGWPVFDTAVGKVGVYICYDRHFPEG
                     WRQLGLNGAQLVYNPSATHRGLSSYLWRLEQPAAAVANEYFVAAINRVGVEEYGDNDFY
                     GTSYFVDPRGQFVGETASDKEEELIVRDLDFDLIEEVRQQWAFYRDRRPDAYEGLVQP"
     gene            17349..18632
                     /locus_tag="EHO50_RS28980"
     CDS             17349..18632
                     /NRPS_PKS="Domain: Aminotran_3 (26-363). E-value: 7.9e-74.
                     Score: 240.6. Matches aSDomain:
                     nrpspksdomains_EHO50_RS28980_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328583.1"
                     /locus_tag="EHO50_RS28980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_128434166.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-81, bitscore:
                     269.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKDLLGRHRAVMPDWLALYYEEPLEITHGEGRHVWDSAGNRYLD
                     FFGGILTTMTAHALPEVTKAVSEQAGRIIHSSTLYLNRPMVELAERIAQLSGIPDARVF
                     FTTSGTEANDTALLLATTYRQSNTILAMRNSYHGRSFSAVGITGNRGWSPTSLSPLQTL
                     YVHGGVRTRGPYAQLSDDDFIAACVDDLVDVLGHTRPPAALIAEPIQGVGGFTSGPDGL
                     YAAFREVLAERGILWIADEVQTGWGRTGDHFWGWQAHAQSGPPDILTFAKGIGNGMSIG
                     GVVARAEIMNCLDANSISTFGGTQITMAAGLANLNYLLEHDLQGNARRVGGLLVERLRA
                     VAAQAPHVREVRGRGLMLGIEITRPGTDEADPAAASAVLEAARDGGLLIGKGGGHNTTS
                     LRVAPPLSLTVAEAEEGAAILESALRSI"
     aSDomain        17427..18437
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EHO50_RS28980_Aminotran_3.1"
                     /evalue="7.90E-74"
                     /label="EHO50_RS28980_Aminotran_3.1"
                     /locus_tag="EHO50_RS28980"
                     /protein_end="363"
                     /protein_start="26"
                     /score="240.6"
                     /tool="antismash"
                     /translation="ITHGEGRHVWDSAGNRYLDFFGGILTTMTAHALPEVTKAVSEQAG
                     RIIHSSTLYLNRPMVELAERIAQLSGIPDARVFFTTSGTEANDTALLLATTYRQSNTIL
                     AMRNSYHGRSFSAVGITGNRGWSPTSLSPLQTLYVHGGVRTRGPYAQLSDDDFIAACVD
                     DLVDVLGHTRPPAALIAEPIQGVGGFTSGPDGLYAAFREVLAERGILWIADEVQTGWGR
                     TGDHFWGWQAHAQSGPPDILTFAKGIGNGMSIGGVVARAEIMNCLDANSISTFGGTQIT
                     MAAGLANLNYLLEHDLQGNARRVGGLLVERLRAVAAQAPHVREVRGRGLMLGIEIT"
     gene            18655..20238
                     /locus_tag="EHO50_RS28985"
     CDS             18655..20238
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656768.1"
                     /locus_tag="EHO50_RS28985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_128434167.1"
                     /transl_table=11
                     /translation="MTTTSTTWERLEPVLSVRQVLTLERVLAGEPEVVAGAGHLDRPVR
                     WVHVAEAPDVGVMLSGGEMVLTTGVLLAGDEEKQAEYIRSLHRAEAAAVVLGLGRAFPA
                     PPDVMRRAAERCGLPMVVLHRPFPFAELTEEVQSRLVRRKFAAVSLSEAVRTALTGLIT
                     AGAPLQRLLDEVAAHSACPVVVTNLAHRVLATAGERSAVDDVLRDWERIARQAGGSEGD
                     GWIRAELGGRGERWGQIMLCGHRGDTATGRLLAERAAEALVLHRMLGGNSAHTWEEQSA
                     QSLLTDLVSGVVPARQLLPRARAAGLPVNRRAFVPLVVRDGEAAQLERVLRMLGLSGIV
                     AELADGATAVLLSLARDQDAAVLAANFAARVRSESGAARTVIAAADARTAWDDVPAGLR
                     EAQHVADAVADSSAALDLPAVVRLKDVHLRGLIRLLRDDPQVQSFAERELDGLLCGRDD
                     EVGALLAVLRTYLATGRNKSRTAQLHHVSRPALYRRLEAIQTRLGVDLDDFEQAASVHI
                     ALLAHDAQLG"
     misc_feature    complement(20314..20326)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     gene            20419..21261
                     /locus_tag="EHO50_RS28990"
     CDS             20419..21261
                     /GO_process="GO:0006807 - nitrogen compound metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675953.1"
                     /locus_tag="EHO50_RS28990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_128434168.1"
                     /transl_table=11
                     /translation="MSRVIRAALFQTAWTGDKESMIQVHEQAARDAAAQGAQVLCFQEL
                     FYGPYFCQVQDKAFYEYAEQIPEGPIVKRFQALAKELGIVLILPMYEEEQPGVLYNTAA
                     VIDADGSYLGKYRKHHIPQVPGFWEKFYFRPGNVGWPVFDTAVGKIGVYICYDRHFPEG
                     WRALGLAGAEIVFNPSATSRGLSAYLWQLEQPAAAVANEYFVGAINRVGVEELGDNDFY
                     GTTYFVDPEAQFVGEVASDKETELVVRDLDMAKLREVRDRWQFYRDRRPDAYSPLTAP"
     misc_feature    21723..21738
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.72"
                     /tool="antismash"
ORIGIN
        1 atcgagctgc gtgacgtcaa caagcacttc ggggacctgc atgtgctgca ggacatcaac
       61 ctcaccgtcg gcagggggga ggtggtcgtc gtcatcggcc cgtcgggttc gggcaagtcg
      121 acgctgtgcc gggccatcaa ccggctggag accatcgagt ccggcacgat catgctggac
      181 ggtcagccgc tgcccgagga gggcaaggcc ctcgcgcggc tgcgcgccga ggtcggcatg
      241 gtcttccagt ccttcaacct cttcgcccac aagacggtcc tgcagaacgt ctcgctgggc
      301 caggtcaagg tccgcgggcg caagaaggaa gacgccgaga agcgctcccg ggaacttctc
      361 gaacgcgtcg gcgtggccga ccaggcggac aagtacccgg cgcagctctc gggcggccag
      421 cagcagcgcg tcgccatcgc ccgggccctc gccatggggc cgaagatgat gctgttcgac
      481 gagcccacct ccgcgctcga ccccgagatg atcagcgagg tgctcgatgt catgcaccaa
      541 ctcgcccgcg acggcatgac gatgatggtc gtcacccacg agatgggctt cgcccgctcg
      601 gccgccaacc gcgtcgtgtt catggccgac ggccgcatcg tcgaggaccg cagccccgac
      661 gagttcttca ccaaccccag cagcgagcgc gcccgggact tcctctcgaa gatcctccat
      721 cactgagcgg ggagtacgac ccatgccgag acgaagggcg tttttccaca ccggaatcct
      781 cgccgtgtcc gacgtcgact acgatgtttc gtccgtcccc aaggccgtgg cggtggcccc
      841 ggccgcgacc agggacgctg ctgccgggtg gggatccccc cacggcccct agaccagggg
      901 cagcaggggg cagcagtcac agagccatac ccgcccggcg ccggccggag atcactgctc
      961 gcgcagtgga atcgacacgt acgacgggtc gttcgccggt gaggagaagg tcagccgcgc
     1021 gccggtcggg ttgtgctcga tgtagagcgg gtcgaccgtg tcgacgacca gggcgagacg
     1081 gtgccctgcc ggaacgtcgt aggccgtgga gtacagctcc aggtcgacgg cgaacggctt
     1141 tccgggcgta cgtccgtgga aggtgtacgg cgcgttgctg accagcttgc cgaggccgag
     1201 cgggcccacg tcgtagaggt aggcgacgag ggtgccgctc tccttggtcg gtgtgagggt
     1261 ggtgtgcaac ttcgccgtac cgcgcacgtg ttggggggtg gcgtacttct cggactgcca
     1321 gacgcccgcc cagcgccggg ggatcagcgg gatcgaggcc accggcggca gttgggccac
     1381 ctggtcgagg atgctggaca ggaagacgac cccgccgtcc gcgcccgagt tgacgttcgt
     1441 gtggatggtg gtcgtgccgc cgagggcgat cttcttgttc gtcgcgccga ccgacttcca
     1501 gtccggatag ccctcgtagc cgcccgcgga acgggacttg agctggaccg gcagctcgcg
     1561 gttgatgccg ttgtcctcgc ccttgaggtg gtggtcgaac cagcgctcgg tgtccgtcca
     1621 cacgtcgttg ggcaggccga acaggccggt cagctcggcg gtggcgtggt cgccgggacg
     1681 gaactccagt cgcttggggc cggtcagctt ctcgtagaag tccgcgtact ggttgggcgg
     1741 gaagatcgtg tcgccccagg cgttggccat catgaccgcg gcgccgttgt tgttcagttg
     1801 atccacgtat gtagcgaccg aacgtttctt cccccaattg atcatgtcct gttccttgga
     1861 caggttggag gcgtagaagt cgttgaagat ctgccggact tcggcgctct ggcggccggt
     1921 taccaggctc gcgccgtcca atagtgcggc cgcctggacg tgctgggtgc ggccggagta
     1981 gatcgagccg atgaggtcgg cccagccgct gagggcggcg accgccttga cccgtttgtc
     2041 gtgcgcggcg gtcagcaggc tgatgccggc gccgtacgag acgcccgcca tgccgatgtg
     2101 ccccgcgtcg gccggggtgt tggcgagagc ccagtcgatg accctggacg cgtcggctat
     2161 gtcgggtggg cccgccactt ctatctcgcc gcccgactgc cagaagccgc gcacgttgta
     2221 actcaccacg acatagcccg agttcgcgag cttctgtgcc tgcgcgaagt actcgacctg
     2281 gggcaggccc cagctcgtgg gcaggacgag cagcgggaag cggcggctgc cgtcggcgcc
     2341 ggccggcgtg atgacgttcg ccttgagcgt ggtgccgccg tcgccgctga tgtcgacgaa
     2401 gcggacgctg ttcgtggccg ccccggcggc cggggcgagc ccgagggcgc taccggcgat
     2461 cagagtcgcg gaaacggcgc ccacggcggt cgtacgcagg gccttgcgat ggtgtcccac
     2521 gggtcactcc tcactcgtgt cagtgcaaag tgaccgaacg gtaaccgggg ccccttaccg
     2581 caagtaaccc gtcggtaagt tacgtgccag taacgattac cggaatgtga tgaacctcag
     2641 gaggtgcggt gggtattgcg cggagccgct ggtgtcggca gcggcgcctg cgccgcccgt
     2701 gtcacgtccg cgaccagctc gacgacgtcc ggaccgtacg cctgcgagtt gaccaccttt
     2761 agcaacagga caaaggagcc ggtgccgtgc ttgcgggtga gccgctcgtg gttgcgggcg
     2821 aggtagcggg tggcggcctg gttggtgatc gcggtctggc cgcagaagag gaagacgggg
     2881 cgggtgccgt ggctctgccc gacggtgagc cgggcgagga gcgcgtactc ctccttgccg
     2941 acctccaccc ggtagcgctc ggaaccgacc tgcagggcgc cccggtccgg gccgggttcg
     3001 gcgtcgacgt tcacccgcac cccgggcagc agggatgcca ggtgcgccat catgcggcgg
     3061 ttcgatgccg ggccgccgac gcagaactcg gtgcgctcac cgaagccctg gcgcgccgcg
     3121 tcgtgcggga cgatctgggc gtgggcgttg cagtccttga tgagggcggc gagttccagg
     3181 agtgcgaaca cgtcgtagcg catcaccgtc agctcgggcc caccggcgcc gcggttgacc
     3241 accagcaagg actcggcgtt ctcgggcagc ccgaagaagg cctgcttgcg gcggagcttg
     3301 cgcttccaca ggtaggtacg ggcgagccag cccagcccgg cgctgatgcc cgccgcgacc
     3361 acgcccagca cgatgttgcg cacgtcgtca ttcatgggcg cgcatggtag cgggcgaacg
     3421 caaaccgttg ttcgagacag gtgtccacgc gctcctgacg agggcatggc gatcgattag
     3481 gctgcgccaa cagcccttgt atggaggtgc ggatgcgtcg ccctgtcgcg cggaaactgt
     3541 cggtcctggc cgtctcggcc gccgtggtgt cggtgggggc ggcggcgccg cccgccgcgc
     3601 agagcggccc cgccgcgaag gtgcccgtgg ccgtcggcta cggcggtgcg gtctcgagcg
     3661 tcgacgcgga cgcctccgcg gccggcatcg aggtcctgag gaagggcggc aacgccgtgg
     3721 acgccgccgt ggccacggcc gccgcgctcg gcgtgaccga gccctactcc gccggcatcg
     3781 gcggaggcgg ctacttcgtc tactacgacg ccaagtcccg tacggtgcag accatcgacg
     3841 gccgcgagac cgcgccgctg accgccgact ccgacctgtt cgtggagaac ggcacggcga
     3901 tcccgttcgc cgaggccgtc agcagcggcc tgagcgtcgg caccccgggc acgcccgcca
     3961 cctggcagaa ggcgctggac aagtggggca gcaaggggct cggcacgctg ctcggacccg
     4021 ccgagcggct cgcgcgggac ggcttcaccg tcgacgacac cttccgcgcg cagaccgccg
     4081 ccaacgagac ccggttccgc tacttcccgg acaccgcgaa gctgttcctc ccgaacgggc
     4141 agctcccggt cgtcggcgcc accttcaaga accccgatct cgcccgcacc tacgcggagt
     4201 tggcgaagag gggtgtaggc gcgctctacc ggggcgacat cgccgaggac atcgtcgaca
     4261 cggtcaacca cccgcccgtg gacccgggtt ccggctggaa ggcccgcccc ggcgacctga
     4321 ccgccaagga cctggccggc taccgcacca agtcccaggc gcccaccagg acctcgtacc
     4381 gcggtctcgg cgtctactcc atggcgccct cctcctccgg cggtacgacg gtcggcgagg
     4441 ccctcaacat cctggagaac accgacctct ccaaggcgag cgaggtccag tacctgcacc
     4501 gctacatcga ggccagccgt atcgccttcg ccgatcgcgg acgctgggtc ggcgaccccg
     4561 ccttcgagga cgtaccgacg aaggagctgc tgtcgcagaa gtacgccgac tcgcgggagt
     4621 gcctgatcaa ggacgacgcg gtgctgacga gcccggtcgc gccgggtgac ccgcgcaacc
     4681 cggccgcctg cgacgcgagt ggcactccgg cgccgaccac ctacgagggt gacagcacca
     4741 cccacctcac ggtggccgac aagtggggca acgtcgtctc gtacacgctg accatcgagc
     4801 agaccggcgg cagcggcatc acggtcccgg ggcgtggctt catcctcaac aacgagctga
     4861 cggacttctc cttcacgccg gccagtgcgg ccgtccacga cccgaacctg ccgggcccgg
     4921 gcaagcggcc gcgctcctcg atgtccccga cgatcgtgct cgaccggcac aacaagccgg
     4981 tcgtggcgct cggttcgccc ggtggcgcca ccatcatcac caccgtgctg cagacgctga
     5041 ccggcttcct cgaccgcggg ctgccgctcg tcgacgcgat cgccgcaccg cgcgccagcc
     5101 agcgcaacca gaccaccacc gagctcgaac cgggcctgtg gagcagcccg ttgaagggcc
     5161 ggctggaagc gatcgggcac ggattccggc agaacgccga gatcggcgcg gcgaccggtg
     5221 tgcagcggct gccggacggc aagtggctgg ccgccgccga gacggtacgg cggggcggcg
     5281 gctcggcgat ggtggtgcgg ccggcgccgt agcgcctcac cgcacgcggc gcgtcacaac
     5341 tcgggggcgg gcggcagctc ttccgtacgg aaggcgagcc gcccgtcctg cacatccacc
     5401 gtcacccggc cgccctctcc gatccggccg tccaggagca gccgggagag ctggttgtcg
     5461 acctccttct ggatggtgcg gcgcagcggg cgggcgccgt attcgggctg gtagccgcgc
     5521 tcggagagcc agtcgaccgc cgtgccggtg aagtcgaccg agacgccctg ggcccggagc
     5581 aggcggcgcg tctggtccag cagcaggttg gtgatccgct ccaactggtc gtgggtcagc
     5641 tggcggaaga cgacgatctc gtcgatgcgg ttgaggaact cgggccggaa gtgctcgcgc
     5701 agcggccgca ggatccgctc gcgccgcgcc tcctcgtcgg cctcctcacc gcccgccccg
     5761 aacccgatcc cggtgccgcc ccggctgatc gcctcggagc cgaggttgct ggtcatcacg
     5821 atgaccgtgt tggtgaagtc gacggtccgg ccctgggagt cggtcagccg cccgtcgtcc
     5881 aggacctgca gcaggatgtt gaagacgtcc gggtgggcct tctcgacctc gtcgagcaga
     5941 agcagcgagt acgggtgccg gcgcaccacc tcggtgagct ggccggcctc ctcgtggccg
     6001 acgtatccgg gcggggcgcc gatcagacgg ctgacggtgt gccgctcctg gtactcgctc
     6061 atgtcgaggc ggaccatgcg ctcctcgctg ccgaacaggg cctcggagag cgcccgggcc
     6121 agttcggtct tgccgacgcc ggtcggaccg aggaagagga agctgccgat cggccggtcg
     6181 gggctcgcga gtccggcccg cgagcgcagt accgcgtcgg agacgacgcg caccgcctcg
     6241 tcctggccga cgacccgctc gtgcagatgc tcctccaggc cgagcagctt gtccttctcc
     6301 tcctcggtga ggctgctcac cgggatgccg gtctgccggg acacgacctc cgcgatcgcc
     6361 tcggcggtga cctccaggtg ctggccttcg tcgacctcct cgtcgccggc cgcgtccgcc
     6421 atgcgctgct tcaactcgac gatgcggtcg cgcagttggg tcgcctgctc gtaactctcg
     6481 tcggcgacgg cctggtcctt gtcccggtac agctgctcga cctcgcgctc catggcccgt
     6541 acgtccgtgc ccttggtccg cgcgtgcagc cgcactcggg cgccggcctg gtcgatcagg
     6601 tcgatcgcct tgtccggcag gcggcggtcg gtgagatagc ggtccgacag ttcgacggcg
     6661 gcgacgagcg cctcgtcggt gtagcggacc tggtggtggg cctcgtagcg gtcgcgcagg
     6721 ccgcgcagga tctcgatggc gtcggcggtg gtcggctcgg ggacgaggat cggctggaag
     6781 cggcgggaga gtgccgcgtc cttctcgatc ctgcggtact cctccagggt ggttgccccc
     6841 acgatgtgca gctcgccgcg cgcgagggcc ggtttgagga tgttcccggc gtccatggag
     6901 ccgccctcgc cgccgcctcc ggcgcccacg accgtgtgca actcgtcgat gaagacgatc
     6961 agttggtcgg agtgcgagcg gatctcgccc acgatgttgt tgagccgctc ctcgaagtca
     7021 ccccggtagc gggtaccggc caccacgccc gtcagatcga gcgcgatcac ccggcggccg
     7081 ctgagcacgt cgggcacgtc gctgtccgcg atccgctggg ccaggccctc cacgatcgcg
     7141 gtcttgccga cgcccgcgtc accgatcagc accgggttgt tcttgccgcg ccgggagagc
     7201 acctcgatgg tctgctcgat ctcctcgtcc cggccgatca ccgggtcgat acggccgcgg
     7261 cgggcgaggt cggtgagatc gcggccgtac ttgtcgaggg tgggcgtacc ggtgtcgacg
     7321 cgcggccgct gatcgatacg gggccgggaa tcgggggcgt ccgaggcctc ggacggcccg
     7381 ccggaggggg cgaaccgggc cgcgttgagg atgtgccccg ccgcggagtc ggggttcgcg
     7441 gcgagtgcgc tgagcacgtg ctccgggccg atgtaaccgg cgccgcgcgc ccgggccagg
     7501 tcgtgcgcgt ccagcagggc gcgcttggcg gccggggtga gggagagcga cgtcggggga
     7561 ggggcctcgc ccggcgggtg ctggaccggg cccgagcgct cgtcgatctc cgtcgccagt
     7621 gagtccgggt ccgcgccggc ccggctgagc agactccgtg tcggctcggc ggacagcgcg
     7681 gcacgcagca ggtgctgggt gtccagatcg cggctgccgt gctcggcggc gtactgggcg
     7741 gcgccccgca ccagctcccg ggccggctga ctgagcaggc ggccgatgtc gatctgtcgg
     7801 gggccggggc gcggtccgcc gaagaagcgg gcgaggaatt ctccgaaggg gtcgtagtct
     7861 tccggaccac cattgaagcc gctggtcatg gcgttcccat ccggcgtccc tgcgcgggca
     7921 gggtcgccct cgctgatcga cgtgccgggg ccgggtaacc gggttcgggc acgctcatgc
     7981 cacgatggca cgttctggcc cagggggcat gtgcaggaac acccgggcgg ggcatgtgca
     8041 ggaacccccc ccgggcttcg gccgcttcgc accgcttgcg gtggtcgggt gcgcgtggca
     8101 gggcgcgctc cggcgcgacc tcctcagccg ttcgcccgac ggccgtcggg gtccgctgac
     8161 ggaccgccgg ggcgcagcat ctggctcgtg gccaggtcgc ggtagagggg gtcgcgggtc
     8221 agcaggtcct cgtggcgtcc gcaggcggcg ctgcggccct cgtggagcac gacgatgtgg
     8281 tcggcgtgct gcacggtgga caggcggtgg gcgatgacca gcagagcgca ttcctgggcg
     8341 atctctttca tcaccgtggt cagcgccgcc tcgttgatcg cgtccaggtg ggaggtgggc
     8401 tcgtccagca ggagcagcgc ggggcgggcg agcagggccc gggccagggc gacgcgttgg
     8461 cgttcgccgc ccgagagggt gccgccgcgt tcgccgatga cggcgtccag accgccgggc
     8521 agccggtcga cgagctcctc cagccgggcc agctcgagga cccgccggac ctccgactcc
     8581 ggggcgtcgg gcacggcgta ggtgatgttc tcccgcaggg tgccgtgtac gacgtgggtg
     8641 ttctggtcca ccacggcgat gcgccggcgg caggcgtcgc ggccgagctc ggcggcgggc
     8701 cgcccgtcga acagcacggt tcccgcgtcc ggttcgtaga accccgccac cagcgcgaag
     8761 acggtgctct tgccggctcc cgagggcccc accagggcca cgtgccggtg gtgggggacg
     8821 gcgaaggaca caccggacag caccggtcgc cccggggcgt agccgaaccg gacgtcgtgc
     8881 agcgcgagcg cgggccggtc ggcggggacg gacgggacgg gccggggacg ggggcgggcc
     8941 tgctcgaccg ccggccccgt gtgttccacg gggaggcgca gcgcctggtc gacgcgccgg
     9001 taggcgccca tgccgcgctg gatcagcccc accgcgtgga acacggagga cagcggcagg
     9061 acgaggtacg aggcgtacag caggaaggcg acgaggtccc cgagggagcc ggcgtgaccg
     9121 ctgatccgca ggccaccgac gacgagcacg atgaggaagg agccctggac ggcgagttcg
     9181 acggcggggc tcatgacgga ggcgagcttc gcggtgcgga cccccgcgtc gtaggcctcc
     9241 tcgacccggc gcccgatgcg ggcggcctcg cggtcctcgg cgcggtgcac gcggaccatg
     9301 ggcagcgcgc ccagggcccg ttccaggtcc gcggcgacgg caccgaccga gtcctgcata
     9361 cgctcggacg ccttccgcag gccctggagc agcgaggtga ccacggccgc ggcgacggcc
     9421 acggtgagcg cgaccagaag cagcaacagc gggtcgagcc acgccatcag gatcaccgct
     9481 ccggcggcga cgagggtccc ggtcaccagg tcgaccaggg cctgcgagac gacctcgcgc
     9541 agcagggtgg tgtcggcggt gacccgggag atgaggtcgc cgttgcggtg gcggtcgtac
     9601 tcccgcatct ccagccggag caggcgcccc accaggccga cccggagctg gcgtacgacg
     9661 ccctcgccca tccgctccag caggaagcgt cccgccgagc cgatcgccgc ttcgacgagg
     9721 aacagtgcgc cgagcagggc cagcagcggc cagacgacct ggccgcgggc gctggcgtcc
     9781 acggcatgcc gggccaccag cggctgggcc agccccagcg cggagccggc cagcgtcagt
     9841 gcggtggcca cggcgacggc ggtccggtgc ccggcggtga ggccgtacag cgtggccacg
     9901 gccgcgcggg tcgaccggtc ctcgtaggcg ggctcgtggg gcctgtggcc cgcgaccgtg
     9961 ctgcccgccg ccggcccggc gtccgcagcc gccccgccgc tcacaggtct gccggctcga
    10021 cggccaccag ccgggcgaaa taaccgtcgg gtacgccctc gcccacgggg cggccctccg
    10081 cttcgatcca ggcgtgcgcg gtgaagggcg ggacgacgcg gactccggtg caccaggtcg
    10141 gccacgtccc cctcagccgg cacagcagcg cggcccccag ggagcgcggc aggcacccct
    10201 tcgggccggc gcagcgcagg ctggcggcgc acatggcgtc gcgcgcgtcc tgggcctgcg
    10261 tggtggtggc gggcgcggca ccgcgccgca ccacgcccag cacggtgcgg atacggcggg
    10321 gtggcaggag ggcgagggcg acggcgggga gcaggacgag gagggcggcc aggcggtggc
    10381 cgaggggcac accggtgggg cgttccagcg cgctgggtgt cgtcatgagg ccagtcccgc
    10441 ctcgcgtagt tgaccgacga gcgcctcgac gtcccgctgg gcctgtgccc ggtcgatgtc
    10501 gaaatcgcgg atcagggcgg ccgtcgcgtc cgcctcctcg ccgccgtcga gcagggtacg
    10561 gaccacgagg gtggcggtcg ggttcaactc ccagtaggta ccggctcgtt cgtccagcag
    10621 tacggtgccg tagtcggtct cggcggtgga gatgtgtgcg tcgaaccgca agggcatgcg
    10681 ctcgcctttc tgacggggtt ctcagggagt gcgggcacgg ctgtgggaca gcccccgcag
    10741 ccatacctcg gcggcgatgg tggagtagag gatggcgtcg gagaggcccg gtgaggtggg
    10801 gcgctgggcg aggcggcgca gctcggcgcc gtccaccagg cccagcgcct ccagccgtga
    10861 gccctcccac atggtcagca ggtcgccgcg gtgccggcgc agtccgttgg cggcgtccat
    10921 ggcggccgtc gccttgttgg cccgccgcag gcagtcatcg ggcacgattc cgcgcatcgc
    10981 ggcgctcagg acgggcttgt actgccaggg agtgacgcgc tcgctcgggc ggacggcgag
    11041 aaacgcctcg atgacgcggt cgtcgaagaa gggggaggcc atcggcaggc ccgcgcgcgc
    11101 cgccatccgg tcccattgcc ggatgacgcg ggtgcacgag cggatctgct ccaggtcggt
    11161 gtgcagtcca cggtccggat gcagcggcga ggccgtggcc gccgcgtcga gcagtgcccg
    11221 gcgggccatc cgctcagcct cgggggtcac ccagtcgaac aggcgcgggg ccatgcccca
    11281 gccgagactc gtcgcgacgg acgagggcaa cgggccacgc agccggccgg ctccgtcggc
    11341 gagccacttc ccgtacggcc gggagtcggc gagggcgagg gccgtgccgc ccagtggcca
    11401 ctgccacagt gcccggtacc cacgcaactg gcgcagggcg aacagcggac gggtgcgcag
    11461 cagccggtgg tagtacgcgt cggagcacca tgccacgtgg tcgccgccga ttccggtcag
    11521 gtgcacccgg ctgccgcgtg cggcgaggcc cggcaggtgg tgcaggaccc gggagcggtc
    11581 catgacgccg atggtgggct cgtccaggag gtcgtcgatg ccgagcagat cctcgtagac
    11641 cagcggcgag gcgtcggcgt cccacaccac gtgctcgacg tccgggaggt gccccatggc
    11701 ccgctgagcc cagtgcaggt cggtgtccgc cggatcgcgg cccggccagg tgctggccac
    11761 cacgtgggcg ggggaacggt cggccaggaa gcagatggag gtcgagtcca ggccgccgga
    11821 cagatcgcag ctcaccactc cgccctgccg ggtccgcgcg cccacggcct cctccagcgc
    11881 ggtccggatc aggggcgccg cctcggcgag tggccgcacc ggctccggcg gcgtccacca
    11941 ccgggtgtgc cgtacggtgc gcccgtccgc ggcgacgatc acggcgtcct gcgggggcac
    12001 agcggtgacc gggcgccaca gggaagtctc gaacaggggg tagggggcgg gccacagcag
    12061 ccggacggcc agctcctgcg gatcggggtc gaggccgagc gcggcggcga gcgtgtcggc
    12121 gcgggtggcg gccacccgga cgccgtcgat ctccgcgtgg aagaccagcc gcaggccaga
    12181 ggcggtgccc tggacacgga tctgtccgtc gagggcggcg acgaggtgga agctgccggg
    12241 gagggtgcgg gccggcgcgt cgagttccgt cagatccctc agccgtgcgg ccgtacgccg
    12301 cagttgcgcc gcctcgacgg ggcagcagcc gatgacggcg agggtggcac tcccggcgct
    12361 cgcggtgacg atctcgtcgt cgtgccagtg gccgaccagc cagggccggc ccgacgcgtg
    12421 tgcgagggtc cggctaccgg ggcgggcgaa ggagcgggcc acggcggccg cgtccgcacg
    12481 gtccggaaag accgcgaagt gcgcgtcgcc ggggcccgtc cccgcacttt cgtgcagttc
    12541 agtcatgacg tcgggtcagt gccgtcgccc gtcagttctt gctgaagatc agccggtcgt
    12601 tgccggagct ctgaaggagc cccgtctcct tgcggaacgt cccgagcctg acgagcgtcg
    12661 gcgcttcgta tgccttcttc atgacttctc ctcactgcgg gtggtgtccc agtccccggg
    12721 cggggaccgg acgcaacacc agctagctgc ggaaggtgag ggtgaggcaa ggtgcagcac
    12781 gaaagtatga cggtatgaaa aggcagatga ctccggcctg gaaggggcgc acgtgcccgg
    12841 cgtgagacgt cgcgcccgtc gacggctttg cgtgtgcata tgcgaagaaa cgttcccagg
    12901 tgtggctctc cgcggcggcg cgcgccatgt acgaaaaccg ggcagggggg ccgccggggc
    12961 gcactgcgcg gccgtcggtg cgcaccatgt ccggcgggcg cagggcccgg cgggaggtgc
    13021 ggtcagaggg cttcccgcgc ggtgaggatg cgcggtcccg cgtcggtgat cgccaccgtg
    13081 tgctccacgt gcgccgcccg ggagccgtcg ttcgtgcgca gggtccagcc gtccggggcc
    13141 gcgtggtagc cgtccttgcc gctcgcgatg agcatcggct cgatggcgag gaccatgccg
    13201 tggcgcagcg gcatgccccg gccggggcgg ccctcgttcg gtaccccggg atcctcgtgc
    13261 atcttgcggc cgatgccgtg cccgccgaag ccgtccggga tgccgtaccc ggcggcccgg
    13321 cacaccgagc cgatcgcgtg cgcgatgtcg ccgatgtggt tgccgaccac ggccgcatcg
    13381 atgcccgccg ccagcgcccg ttccgccgtc tcgatcaggc gtacgtcggc ggggcgcgcc
    13441 ccgccgaccg tgaagctgat cgccgagtcg cccgcccagc cgcccagttc ggcgccgcag
    13501 tcgatggaga cgaggtcgcc gtcgcacaag cggtaaccgg tcgggatgcc gtgcacgatc
    13561 gcgtcgttca ccgacgcgca gatgacggcg gggaacggaa cgggggcgaa ggagggccgg
    13621 tagccgagga agggggaggt cgcgcccgcc gcacgcagca cctcacgcgc cacctcgtcc
    13681 agctccagca gggaaacccc cacgtcagca gccttgcgta cggccgtcag ggcctggccg
    13741 acaacctgcc cggccgcgta catctcatcg atcgacgtat ccgtcttcaa ctccaccatg
    13801 ccaattacta taccggtatt tgaatgggga tcggcgagtg gaggcggtat tagaatgggc
    13861 gccatggtgc gcacccctct cacccccgaa gagcgtgaac gcggcgagcg gctcggccgg
    13921 ctgctgcgcg aggcccgcgg cggccgcagc atggcggaga tcgcggcgaa cgccggtgtc
    13981 tccgccgaga cgctgcgcaa gatcgagacc ggccgggcgc cgacccccgc cttcttcacg
    14041 gtggccgcgc tggcgcacgc cctcggtctg tcgatggacg aactggcggg gcgctgcaca
    14101 ccggttgtcg aggctgcagc ctgaggggcg cgcacgtcac gttccggcag ctgcggcgta
    14161 ctctgcgtcc attcagaaaa ctccccgtag cgcattcgta acatggctgg tgttgcctaa
    14221 cggatcggag cactccggtc tggcgggagt tgggcgatgt cagtggatca actcccggcc
    14281 cgggtacggg agttcgtgaa ctacctggac ggtcttctgg cgcgcctgga tcagggcggc
    14341 ggctggtgcg gggtgttctg gcagcgcgac ccggagggca tgcaggcctg tctcgacgga
    14401 cgggaagtgc cgccctggga tgtggtggag tcgctcctgc acgacctcgg cgcccagtac
    14461 ggtcccggcg gcgcgggccc cgagacggaa cgcgcccgcg ctctgcacgc cgccgccctc
    14521 gccgtgtacg actcgcggcc cggcggccgt gacgccctcg gcgaccggct cgacgtcatg
    14581 ctccgcgagc agcggtacgc cgccgagcgc caggcggacc tcggccgctc gctcgccgcc
    14641 gccaccagcc aggaggcggc cgacgccatc cgcctcgacc tcgcctgggc ccgcgacgac
    14701 cacgaacgcg ccaccgcccg gtgcgccgaa ctccgggccc gaatggccga cctggaccgc
    14761 cgggcggcga gcgaacgggg ccaggcgata cggcgggacc gggtggggga ggggtccgtg
    14821 ttccgcgtcg acgagggttt gaggggcgac aggtctgggg gcgaggggcc cagggccgac
    14881 cgcttcgaga acgacgggtt gaggggagag cgggccaggg gtagccggtt cgggggcgac
    14941 cggttcggag ccgacgggtc cggggagagc cggtccgggg acgacaccgt tggcggcgac
    15001 gcattcggcg gcgacggatt cggggactcc gggggcgggg cggatcgtag gcagtcgggt
    15061 gcgatcggat ctcgcggcgg cggattcccc ggcatgccgc atcagcgcga cgcgcggccg
    15121 acgccccgaa cggcgggctg gtccgaaggg cggggagcag ccccggccgg gacggccgca
    15181 gaccggcacg acgggcgccg agccgccacc tcggccgccg aagcggcgca gtggcgcgcg
    15241 gcgcggcagc ggggcttcga cgccgggtcg gcgggaggcc acgactccgt ccacgccggg
    15301 acggaaggcc atgacgccgt ccatgggcag ggcgcagacc cttatgccgg gcgcggcacc
    15361 gccgggccgc ccgactggcc ggacccgcag ggcacgggcg ccggagccga ccgtcccacc
    15421 ggacatcccc tggaccgaac cgccccggac ggcgcgaccg cgccgtccga ctggccggaa
    15481 gccgagcaca cccccgccga cacggcatcc gccgccgcaa ccttcgacgc cgccccggtg
    15541 ccggccgccc ccgacccgac ccccaccccc aagcagcgca agcgccgccg aggcagcgcc
    15601 cgcttcgccg ggatggtcga ggaggaggcc gcccccgtcg tcgtaccgcc gaccgccgcg
    15661 cccacgctcc ccacgctccc caccctcccc gcgcagcccg cccgcacggg ccgtaccccg
    15721 cgcggggcgc ggttcgccgg ggccgccgcc gagacgcccg cgcacacggc cccgcagccg
    15781 aagcgcgagc cgatggaccc ggcggatcgg cgggaggtcg tcgggaccgt ggagacgctg
    15841 gtgcggctgc ggggtgaggg gcgcaccggt gaggcgcatg tgctgctcgt ggaggccgcg
    15901 tactggcccg ccgtccgctt ccccctgctc gccgccgaga tgcagcgcgc cggactcggc
    15961 gccgactggg ccaccctgct gtgggaggcc gcctcgctgc ccgccgagcg gctcgtcgcc
    16021 gcagccgacg cgctgacggt ggcggggcgt gccgacgacg gggagcagat cctgcgccag
    16081 ggcgtggcgc ggcccgcgca cgagatcggg caggccgtgg tggggctggt cggcgaggga
    16141 cggcaccgag aggtccgtgc gctgctcgac gcgtacgtcc gcgtccgcac cccggaggag
    16201 gccgcccgca gcgccgagcc cgccccgaag actctcgtac cgctgctgct ggaggccgcc
    16261 cggggtgtct cggacgagcg ccactgggac cttgtccacg ccctgcgggt ggcgggcttc
    16321 acggcctgac accccccggc gcacccgtcc caccggcccc gtccgtcccc cactggagtg
    16381 tgaaacgtga tcgactcagc gggttaacga cgatggtctt ggcaaggctg tttcgggggc
    16441 ttactttcaa gcctctacgg ccccctctac gggcgtagag gctctgacgt cccgtcgaag
    16501 gagcagctca tggccaacgt cgtacgtgcc gctctggttc aggccacctg gaccggcgac
    16561 accgagtcca tggtggcgaa acacgaggag cacgcccgcg aggccgcccg gcagggtgcc
    16621 aagatcatcg ggtttcagga agtcttcaac gctccctact tctgtcaggt ccaggaaccg
    16681 gagcactacc ggtgggccga gccggtaccc gacgggccga ccgtgcgtcg tatgcaggag
    16741 ctcgcccgtg agacgggcat ggtggtcgtc gtccccgtct tcgaggtcga gcagtccggt
    16801 ttctactaca acaccgcggc cgtgatcgac gccgacggca ccttcctcgg caagtaccgc
    16861 aagcaccaca tcccgcaggt caagggcttc tgggagaagt actacttcaa gcccggcaat
    16921 gtcggctggc ccgtcttcga cacggcggtg ggcaaggtgg gtgtctacat ctgctacgac
    16981 cgccacttcc cggagggctg gcggcaactc gggctcaacg gagcccagtt ggtctacaac
    17041 ccgtcggcca cccaccgcgg gctctcctcc tacctctggc gcctcgaaca gcccgccgcg
    17101 gccgtcgcca acgagtactt cgtcgccgcg atcaaccggg tcggtgtcga ggagtacggc
    17161 gacaacgact tctacgggac gtcgtacttc gtggacccac gcggtcagtt cgtcggggag
    17221 accgcgagcg acaaggaaga ggaactgatc gtccgcgacc tcgacttcga cctgatcgaa
    17281 gaagtgcggc agcagtgggc cttctaccgc gaccgccgcc ccgacgccta cgaagggctg
    17341 gtgcagccgt gaccaaggac ctgctgggac gccaccgcgc cgtcatgccg gactggctcg
    17401 ccctgtatta cgaggagccg ctggagatca cccacggcga gggccgccac gtgtgggact
    17461 ccgccggcaa ccggtacctc gacttcttcg gcggcatcct gacgacgatg accgcgcacg
    17521 cgctgcccga ggtgacgaag gcggtgagcg aacaggccgg gcggatcatc cactcctcca
    17581 ccctgtacct caaccggccc atggtcgaac tcgccgagcg catcgcccag ttgagcggca
    17641 tcccggacgc ccgtgtcttc ttcaccacct ccggcaccga ggccaacgac accgccctgc
    17701 tgctcgcgac gacctaccgg cagagcaaca cgatcctcgc gatgcgcaac agctaccacg
    17761 gccgctcgtt cagcgcggtc ggcatcaccg gcaaccgcgg ctggtcgccg acctcgctgt
    17821 cgccgctgca gacgctgtac gtccacggcg gggtgcgcac gcgtgggccg tacgcgcagc
    17881 tgagcgacga cgacttcatc gcggcctgcg tcgacgacct ggtggacgtc ctcggccaca
    17941 cccgcccgcc cgcggccctg atcgccgagc ccatccaggg cgtcggcggc ttcacctcgg
    18001 ggccggacgg gctgtacgcc gccttccgcg aggtgctcgc cgagcgcggc atcctctgga
    18061 tcgccgacga ggtgcagacc ggctggggcc gcaccggcga ccacttctgg ggctggcagg
    18121 cgcacgcgca gtccggtccg ccggacatcc tgaccttcgc caagggcatc ggcaacggca
    18181 tgtccatcgg cggtgtcgta gcccgcgccg agatcatgaa ctgccttgac gccaacagca
    18241 tctccacctt cggcggcacc cagatcacca tggcggccgg cctcgccaac ctcaactacc
    18301 tgctggaaca cgacctccag ggcaacgccc gacgcgtcgg cggactgctc gtcgagcggc
    18361 ttcgggccgt cgcggcacag gcgccgcacg tacgggaggt acgcggccgg ggcctgatgc
    18421 tgggcatcga gatcaccagg cccggcacgg acgaagccga ccccgccgcc gcgtcggccg
    18481 tgctggaggc ggcccgcgac ggcggcctcc tcatcggcaa gggcggtggt cacaacacca
    18541 cgtccctgcg cgtcgccccg cccctgtccc tcaccgtcgc ggaggccgaa gaaggcgccg
    18601 cgatcctcga gagcgctctg aggagcatct gaaccagcta gcaagggaaa gcccatgacc
    18661 accacctcca cgacctggga gcgcctcgaa ccggtcctgt ccgtccggca ggtcctcacc
    18721 ctggagcggg tgctggccgg ggagcccgag gtggtggccg gcgccggtca tctcgaccgt
    18781 ccggtgcgct gggtgcatgt cgccgaggcg ccggacgtcg gggtgatgct cagtggcggc
    18841 gagatggtgc tgaccacggg ggtgctgctc gccggggacg aggagaagca ggccgagtac
    18901 atccgctccc tgcaccgggc ggaggccgcg gccgtcgtgc tgggcctcgg ccgggcgttt
    18961 cccgcgccgc cggacgtgat gcgccgggcg gccgagcgat gcgggctgcc catggtcgtc
    19021 ctgcaccgtc ccttcccgtt cgccgagctg accgaagagg tccagtcccg gctcgtacgg
    19081 cggaagttcg ccgccgtcag cctctcggag gccgtacgga ccgcgctcac cgggctcatc
    19141 accgcgggcg ccccgctcca gcggctcctc gacgaggtcg ccgcgcacag cgcctgcccc
    19201 gtcgtcgtca ccaacctcgc ccaccgcgtc ctcgccacgg cgggggagcg ctcggccgtg
    19261 gacgacgtgc tgcgcgactg ggagcgcatc gcccggcagg ccggcggcag cgagggcgac
    19321 ggctggatcc gcgccgaact gggcggacgc ggcgagcgct ggggccagat catgctgtgc
    19381 gggcaccgcg gcgacaccgc caccggacgg ctcctcgccg aacgcgccgc cgaggccctg
    19441 gtcctgcacc gcatgctggg cggcaactcc gcgcacacct gggaggagca gtccgcgcag
    19501 agcctgctga ccgacctcgt cagcggggtc gtaccggcgc ggcagctgct gccacgcgcg
    19561 cgtgccgccg ggctgccggt caaccggcgt gccttcgtgc cgctggtcgt gcgggacggc
    19621 gaggcggccc aactggagcg cgtgctgcgg atgctggggc tgtccgggat cgtcgccgag
    19681 ctcgccgacg gggccaccgc cgtgctgctc agcctcgccc gggaccagga cgccgccgtg
    19741 ctcgccgcga acttcgccgc gcgggtgcgc tcggagtcgg gggccgcccg gaccgtcatc
    19801 gcggccgccg acgcgcgtac cgcctgggac gacgtacccg ccgggctgcg cgaggcccag
    19861 cacgtcgccg atgccgtcgc cgactcctcg gccgccctcg acctcccggc ggtcgtacgc
    19921 ctcaaggacg tccatctgcg gggcctgatc cggctgttgc gggacgatcc gcaggtgcag
    19981 tcgttcgcgg agcgcgagct ggacgggctg ctgtgcggac gggacgacga ggtcggcgcc
    20041 ctgctcgccg tgctgcggac gtacctcgcg accggccgca acaagtcccg caccgcccag
    20101 ctccaccacg tctcccggcc cgcgctctac cggcgcctgg aggcgataca gacacggctc
    20161 ggcgtcgatc tcgacgactt cgagcaggcc gcctcggtgc atatcgcgct cctcgcgcac
    20221 gacgcgcaac tcggctgaca aggcgccgcg gaaaccgcgt agaaacacaa gacgacctgg
    20281 gaaaacggcg gtgaaacatg gttcctgcag agggtgacac cgtgacacgc cgcacgcccg
    20341 cagacgtgac accgtgcaac tcaaagcccg ctttcggact tcctagcctt ctcgcacacc
    20401 gagcgaccgg aggtcccgat gagcagagtg attcgcgccg ccctcttcca gaccgcgtgg
    20461 acgggcgaca aggagtcgat gatccaggta cacgagcagg cggcccgcga cgcggccgcg
    20521 cagggtgctc aggtcctgtg cttccaggaa ctgttctacg ggccgtactt ctgccaggtc
    20581 caggacaagg cgttctacga gtacgccgag cagatccccg agggcccgat cgtcaagcgc
    20641 ttccaggcgc tggccaagga gctgggcatc gtcctgatcc tgccgatgta cgaggaggag
    20701 cagcccggcg tcctctacaa cacggccgcg gtgatcgacg cggacggctc gtacctcggc
    20761 aagtaccgca aacaccacat tccccaagtg ccgggattct gggagaagtt ctacttccgc
    20821 cccggcaacg tcggctggcc ggtgttcgac accgccgtcg ggaagatcgg cgtgtacatc
    20881 tgctacgacc gccacttccc ggagggctgg cgggcgctgg ggctcgcggg tgcggagatc
    20941 gtgttcaacc cgtcggccac ctcgcgcggt ctgtcggcct acctctggca gctggagcag
    21001 ccggcggccg cggtggccaa cgagtacttc gtcggtgcga tcaaccgggt cggcgtcgag
    21061 gagctgggcg acaacgactt ctacgggacg acgtacttcg tcgacccgga ggcccagttc
    21121 gtgggcgagg tggccagcga caaggagacc gaactggtcg tccgcgacct ggacatggcc
    21181 aagctgcgcg aggtccgcga ccgctggcag ttctaccgcg accgccgtcc cgacgcgtac
    21241 tccccgctga ccgcaccctg accgaaccgt tcactctggc aggagaggga ccatgagcag
    21301 ccgtaccgtc atccgcggtg gtctcgtcat caccgcgtcc gacgagatcc acgccgacgt
    21361 gctgatcgag gacggccgca tcgccgccct cgccgccagc ggcaccccgg ccgccgaggc
    21421 ctggaccgcc gagcgggtcg tcgacgccac ggggaagtac gtcatccccg gtggcgtcga
    21481 cgtccacacc cacatggagt tgccgttcgg tggcacgcac gcctccgaca ccttcgagac
    21541 cggcacccgc gccgccgcct ggggcggcac caccacgatc gtcgacttcg cggtgcagag
    21601 cgtcggccac tcgctgcgcg agggcctcga cgcctggcac gccaaggccc agggcaactg
    21661 cgccatcgac tacggcttcc acatgatcgt ctccgatgtg aaccaggaga cgctcaagga
    21721 gatggacctg ctggtcgagg agggcgtgac cagtttcaag cagttcatgg cctacccggg
    21781 cgtcttctac tccgacgacg gccagatcct gcgcgccatg cagcgcgggg ccgagaacgg
    21841 cgccctgatc atgatgcacg ccgagaacgg catcgcgatc gacgtgctgg tggagcaggc
    21901 gctggcccgc ggggagaccg acccgcgcta ccacggggag gtgcgcaagg cgttgctgga
    21961 ggccgaggcg actcaccgcg ccatcaagct cgcgcaggtc gcgggcgccc cgttgtacgt
    22021 cgtgcacgtc tcggcgatgg aggcagtcgc cgagctggcg cgggcgcgcg acgagggcct
    22081 gaacgtcttc ggcgagacct gcccccagta cctgttcctg tcgaccgaca acctcgccga
    22141 gcccgacttc gagggctcga agtacgtgtg cagcacgccg ctcaggccga aggagcacca
    22201 ggcccacctg tggaaggggc tgcgcaccaa cgacctgcag gtcgtctcca ccgaccactg
    22261 cccgttctgc ttcgtgggcc agaaggagct ggggcgaggg gacttctcca agatccccaa
    22321 cggccttccc ggcgtcgaga accgtatgga cctgctccat caggccgtag tggaaggccg
    22381 catctcacgc cgccgctgga tcgagatcgc ctgcgcgacc ccggcccgca tgttcggcat
    22441 gtacccgaag aagggcacca tcgcgccggg tgccgacgcc gatgtcgtga tctacgaccc
    22501 gcaggccgaa caggtcatgt ccgccgtgac gcaccacatg aacgtc
//
