LOCUS       NZ_RQJW01000003        20918 bp    DNA     linear   CON 04-MAY-2024
DEFINITION  Streptomyces cyaneus strain CGMCC 4.1671 Scaffold2_1, whole genome
            shotgun sequence.
ACCESSION   NZ_RQJW01000003
VERSION     NZ_RQJW01000003.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces cyaneus
  ORGANISM  Streptomyces cyaneus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1469982)
  AUTHORS   Fang,B.-Z., Han,M.-X., Jiao,J.-Y., Xie,Y.-G., Zhang,X.-T., Liu,L.,
            Zhang,Z.-T., Xiao,M. and Li,W.-J.
  TITLE     Streptomyces sp. nov., a novel actinobacterium isolated from a karst
            cave sample
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1469982)
  AUTHORS   Fang,B.-Z., Han,M.-X., Jiao,J.-Y., Xie,Y.-G., Zhang,X.-T., Liu,L.,
            Zhang,Z.-T., Xiao,M. and Li,W.-J.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-NOV-2018) School of Life Sciences, Sun Yat-sen
            University, No. 135 Xingang West Road, Guangzhou, Guangdong 510275,
            China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 03-OCT-2018
            Assembly Method                   :: SPAdes v. 3.6.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004028635.1-RS_2024_05_04
            Annotation Date                   :: 05/04/2024 03:28:46
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 8,717
            CDSs (total)                      :: 8,635
            Genes (coding)                    :: 8,413
            CDSs (with protein)               :: 8,413
            Genes (RNA)                       :: 82
            rRNAs                             :: 6, 1, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 2 (5S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 222
            CDSs (without protein)            :: 222
            Pseudo Genes (ambiguous residues) :: 0 of 222
            Pseudo Genes (frameshifted)       :: 77 of 222
            Pseudo Genes (incomplete)         :: 187 of 222
            Pseudo Genes (internal stop)      :: 12 of 222
            Pseudo Genes (multiple problems)  :: 50 of 222
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 15:58:52
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 390495
            Orig. end                         :: 411413
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RQJW01000003.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..20918
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20918
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20918
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10918](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10918
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            85..510
                     /locus_tag="EHO50_RS10940"
     CDS             85..510
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020121844.1"
                     /locus_tag="EHO50_RS10940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_128429693.1"
                     /transl_table=11
                     /translation="MKRRIHAICAAAITVLVTAGPASDIAHARNDMDCSDFAFQEDAQA
                     EFNRDPDDHHRLDEDRGRHDGIACEVLPHRNAAVSTPLPIRSPIPTLSPLPTQGVRGGL
                     GGSTGPASFEVALGAGLAVGAVALTAGYFVYRRRFSR"
     gene            complement(628..1911)
                     /locus_tag="EHO50_RS10945"
     CDS             complement(628..1911)
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060760.1"
                     /locus_tag="EHO50_RS10945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation:proton antiporter"
                     /protein_id="WP_128429694.1"
                     /transl_table=11
                     /translation="MHSSAVFLIEFGAIILALGLLGRFAGRFQFSPIPLYLLAGLAFGE
                     GGLLPLGTSEDFVAIGAEIGVILLLLMLGLEYTASDLVSNLKTQYPAGLLDAALNALPG
                     AAMALLLGWGPVAAVVLAGVTWISSSGVIAKVLGDLGRLGNRETPVVLSILVLEDLSMA
                     VYLPIVTALLAGAGLAAGSVTLAIALGVAGLVLLLAVRYGRHISRFVSSDDPEKLLLVV
                     LGLTLVVAGLAQQLQVSAAVGAFLVGIALSGEVAEGAHHLLAPLRDLFAAVFFVFFGLH
                     TDPASIPPVLLPALALAVVTALTKIATGYWAAKRAGISAKGRWRAGGTLVARGEFSIVI
                     AGLAVTAGIEPSLGPLATGYVLILVVLGPLTARYTEPLATRLTERLGRRAPGRSASTAS
                     EAVVEADPSADAPHDVVEDQDVVGRPRT"
     gene            complement(1918..2403)
                     /locus_tag="EHO50_RS10950"
     CDS             complement(1918..2403)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010044113.1"
                     /locus_tag="EHO50_RS10950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cation:proton antiporter regulatory subunit"
                     /protein_id="WP_181449597.1"
                     /transl_table=11
                     /translation="MGAPRLSSTPLPGIGVRYDLTTREQRRLSVVAHRDGSRTLSAYRK
                     DDPDACALSVRLTSGEAATLIDALMPAHHSPNLLSTTELGLVAERVELSATSHWNGRLL
                     GETRMRTETGVSIVAVLRRAEAIPSPTPDFRLSGGDTLIVIGTREGVEAAAAILGRE"
     gene            2833..4128
                     /gene="paaK"
                     /locus_tag="EHO50_RS10960"
     CDS             2833..4128
                     /EC_number="6.2.1.30"
                     /GO_function="GO:0047475 - phenylacetate-CoA ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0010124 - phenylacetate catabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: AMP-binding (84-335). E-value: 2.6e-23.
                     Score: 74.1. Matches aSDomain:
                     nrpspksdomains_EHO50_RS10960_AMP-binding.1"
                     /codon_start=1
                     /gene="paaK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007503538.1"
                     /locus_tag="EHO50_RS10960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phenylacetate--CoA ligase PaaK"
                     /protein_id="WP_128429695.1"
                     /sec_met_domain="AMP-binding (E-value: 5.6e-29, bitscore:
                     97.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADATELLDSGERLGPEALRALQLERLRTSLRHAYDNVPFYRESF
                     DKAGVRPDDCRSLTDLARFPFTTKADLRENYPYGMFAVPQDRVRRIHASSGTTGRPTVV
                     GYTDADLSLWSDMVARSIRAAGGRRGDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPAS
                     GGMTARQVQLIQDLRPEIIMVTPSYMLTLLDEFERQGVDPRGTSLRVGIFGAEPWTEQM
                     RQEIEERFAIDAVDIYGLSEVIGPGVAQECVETKDGLHVWEDHFLPEVVDPITGEVLPD
                     GEEGELVFTSLTKEAMPVIRYRTRDLTRLLPGTARVFRRMEKITGRSDDMVILRGVNLF
                     PTQIEEIVLRTPGVAPHFQLRLTREGRLDALTVRAEARRDASPETRDAAAQAIAAAVKD
                     GIGVSVAVEIVEPESLERSVGKIRRIEDLRPR"
     aSDomain        3085..3837
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EHO50_RS10960_AMP-binding.1"
                     /evalue="2.60E-23"
                     /label="EHO50_RS10960_AMP-binding.1"
                     /locus_tag="EHO50_RS10960"
                     /protein_end="335"
                     /protein_start="84"
                     /score="74.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="QDRVRRIHASSGTTGRPTVVGYTDADLSLWSDMVARSIRAAGGRR
                     GDKVHVAYGYGLFTGGLGAHYGAERLGCTVIPASGGMTARQVQLIQDLRPEIIMVTPSY
                     MLTLLDEFERQGVDPRGTSLRVGIFGAEPWTEQMRQEIEERFAIDAVDIYGLSEVIGPG
                     VAQECVETKDGLHVWEDHFLPEVVDPITGEVLPDGEEGELVFTSLTKEAMPVIRYRTRD
                     LTRLLPGTARVFRRMEKITGRSDDMVILR"
     CDS_motif       3805..3867
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EHO50_RS10960_0001"
                     /evalue="3.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="EHO50_RS10960"
                     /protein_end="345"
                     /protein_start="324"
                     /score="13.3"
                     /tool="antismash"
                     /translation="TGRSDDMVILRGVNLFPTQIE"
     gene            complement(4156..5655)
                     /locus_tag="EHO50_RS10965"
     CDS             complement(4156..5655)
                     /NRPS_PKS="Domain: AMP-binding (13-404). E-value: 2.2e-100.
                     Score: 328.0. Matches aSDomain:
                     nrpspksdomains_EHO50_RS10965_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069067.1"
                     /locus_tag="EHO50_RS10965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_128429696.1"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-101, bitscore:
                     336.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPGHGSTVDGVLRRSARRTPARVAVDHRDRSWTYEELDEAVSRA
                     ARVLLDQGLTPGDRVGAYGHNSDAYLIAFLACARAGLVHVPVNQNLTGDDLAYIVGQSG
                     SSLVLADPDLADRLPDGVRTLPLRDADDSLLARQATASAYDGPEPRSEDLVQLLYTSGT
                     TALPKGAMMTHRALVHEYLSAIAALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATN
                     IILDGPDGEQLFDLIEAGRADSLFAPPTVWIGLANRPDFATRDLDGLRKAYYGASIMPV
                     PVLERLRERWPKLAFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEDG
                     EDVPDGTPGEIVYRSPQLCEGYWDKPEETAEAFRDGWFHSGDLAVRDAHGYFTIVDRVK
                     DVINSGGVLVASRQVEDALYTHEGVGEVAVIGLPDERWIEAITAVVVPRGGVTEAELIE
                     YAREKLAHFKAPKRVVFVDELPRNASGKILKRELRDRFAGD"
     aSDomain        complement(4444..5616)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EHO50_RS10965_AMP-binding.1"
                     /evalue="2.20E-100"
                     /label="EHO50_RS10965_AMP-binding.1"
                     /locus_tag="EHO50_RS10965"
                     /protein_end="404"
                     /protein_start="13"
                     /score="328.0"
                     /specificity="substrate consensus: Leu"
                     /tool="antismash"
                     /translation="RRSARRTPARVAVDHRDRSWTYEELDEAVSRAARVLLDQGLTPGD
                     RVGAYGHNSDAYLIAFLACARAGLVHVPVNQNLTGDDLAYIVGQSGSSLVLADPDLADR
                     LPDGVRTLPLRDADDSLLARQATASAYDGPEPRSEDLVQLLYTSGTTALPKGAMMTHRA
                     LVHEYLSAIAALDLSAGDRPVHSLPLYHSAQMHVFLLPYLAVGATNIILDGPDGEQLFD
                     LIEAGRADSLFAPPTVWIGLANRPDFATRDLDGLRKAYYGASIMPVPVLERLRERWPKL
                     AFYNCFGQSEIGPLATVLAPDEHKGRMDSCGRTVLFVDARVVDEDGEDVPDGTPGEIVY
                     RSPQLCEGYWDKPEETAEAFRDGWFHSGDLAVRDAHGYFTIVDRVKDVINS"
     CDS_motif       complement(4537..4626)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EHO50_RS10965_0002"
                     /evalue="9.90E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="EHO50_RS10965"
                     /protein_end="373"
                     /protein_start="343"
                     /score="27.5"
                     /tool="antismash"
                     /translation="PDGTPGEIVYRSPQLCEGYWDKPEETAEAF"
     CDS_motif       complement(5134..5187)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EHO50_RS10965_0001"
                     /evalue="2.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="EHO50_RS10965"
                     /protein_end="174"
                     /protein_start="156"
                     /score="20.0"
                     /tool="antismash"
                     /translation="LLYTSGTTALPKGAMMTH"
     misc_feature    complement(5721..5741)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 20.17"
                     /tool="antismash"
     gene            5777..8167
                     /locus_tag="EHO50_RS10970"
     CDS             5777..8167
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020114686.1"
                     /locus_tag="EHO50_RS10970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="penicillin acylase family protein"
                     /protein_id="WP_128429697.1"
                     /transl_table=11
                     /translation="MRTRPRRLVVAAVALLAATAGLPATAAERQDRNDSQGRQDLHEQL
                     SHGGLSADVRYTEYGIPHIVAKDYKSLGFGTGWAQAADQVCTLADGFVTVRGERSRFFG
                     PDAATDFSLSSATKNLSSDLYFRGVRQTRTVEKLLAEPAPRGPSRQVKDLMRGFAAGYN
                     AWLKQNRVTDPACKGAAWVRPVTSLDVAARFYAITVLGGQGGAVDDITSAQPPTTGSAA
                     MARGTGTGPSAAALIRAVRERTADAGMGSNAVALRGDTTATGRGLLLGNPHYPWHGGRR
                     FWQAQQTIPGELDVAGASLLGSPTISIGYNSHVAWSHTVSTGVPFNLHRLTLDPADPTV
                     YVVDGESERMKKRTVTVAVKGGAPVTRTQWWTRYGPVVASADGELPLPWTASTAYAIND
                     PNAANMRFADTSLGFSKARGTADVLASLARHQGLPWVNTVAADSSGHSLYTQSQVLPRI
                     TDDVAARCSTDLGKVTYPAAGLAVLDGSRGDCALGRDTDAVQPGTFGPAHMPTLKDAPY
                     AENSNDSAWLANADRPLTGYERIFGNIGTQRSLRTRGAIEDVAALAERGGLTVRDLERQ
                     QFANRAPAADLAATDTATACAALPGGTATGSDGKAVDVTEACSVLAGWDRTMDTGSRGA
                     LLFDRFWRKLTAKVPAAQRWKVPFSAADPVRTPNTLNTAAPGFAAALADTVAELRATGI
                     ALDSRLGEHQFVVRNGQRVPVPGGTEGLGVWNKIEPVWNPAGGGYAEVTTGSSYIQAVG
                     WDGGRCPVARTLLTYSQSSNPRSAHFSDQTRLFSGEKWVTARF"
     misc_feature    8210..8221
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: strong, score: 20.58"
                     /tool="antismash"
     misc_feature    complement(8344..8358)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.74"
                     /tool="antismash"
     gene            8506..9927
                     /locus_tag="EHO50_RS10975"
     CDS             8506..9927
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="EHO50_RS10975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome P450"
                     /protein_id="WP_128429698.1"
                     /sec_met_domain="p450 (E-value: 3.8e-66, bitscore: 219.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAVPEQERVWRTGTAPGIFPILGHGIALFRQPLVFLNSLPSYG
                     DLVEIRLGPQRAWMVCHPELVHEMLKDPHTFDKGGPLYDKLGKLMGDGLVTCRQPAHRE
                     KRRLLQPGFRPSHVATYANLVGEEAESVCQAWSAGQAVRVSDAMMALTTRVISRVLLSD
                     SLDDATSAEVRDCLTVIVRGLFVRTAVPIDALFRLPTPANRRYLRAVDRLHTIIDAAIA
                     DRRRGASHDDVLGTLFAATRGEGGTPAITDQEVHDHLITLLLTGVEAPALCLADAFSLL
                     ARHPVAERRLHAELDAVLPGGRRPGPDDLPHLVYTRCVVSETLRHTSPGWLFTRLTTKE
                     TELAGCRLPQGATVLYSPYLLHHDASSFTEPDRFLPDRWLPGQVTAVQRRAMMPFSAGS
                     RKCLGDEFSMVEATLALATIAGRWRLRHLPGHVEPKPRPAITLGPRTLVMDCEPRATHR
                     VSDSWTAGGNGVDNA"
     misc_feature    complement(9944..9956)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 17.22"
                     /tool="antismash"
     gene            10001..10918
                     /locus_tag="EHO50_RS10980"
     CDS             10001..10918
                     /EC_number="4.2.3.162"
                     /GO_function="GO:0016829 - lyase activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003893.1"
                     /locus_tag="EHO50_RS10980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(-)-alpha-amorphene synthase"
                     /protein_id="WP_220096430.1"
                     /sec_met_domain="T1TS (E-value: 1.2e-54, bitscore: 182.6,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFPFMRNRHESAVTAGVDAWLAVWGLTDDPEVASMIARTRPAEL
                     ASYNCPTMDSGLLQIVANQIAYQFVFDDRAEEIGRHSPGLLLPMLFESIAILRDSRQPS
                     TPLGAALADLHRQVRERCTPAQAARWAWKSREYVHGLLYEAVAQADPLPLRTGHCTSIR
                     SLTAGVEPFHPLCEAAQPHELSLAELHHPVVRRLGRLSADAAVWIPDLFSAVKEQRAGG
                     MINLALAHQREQRCSLPAAVMLAIRQINGTIKEFQGLYAQVEPELSPSGVGYVEGMIGW
                     IRGCYYWSRTVPRYADAACVSALP"
     gene            11147..14017
                     /locus_tag="EHO50_RS10985"
     CDS             11147..14017
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003892.1"
                     /locus_tag="EHO50_RS10985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AAA family ATPase"
                     /protein_id="WP_246101165.1"
                     /transl_table=11
                     /translation="MLIERQRELHALDAAFKELRHTTDGVPRARRRGLLAFTGSAGLGK
                     TALIRAARSRAAAHGFTVLSGRGGEKEQGLAFRVVRQLVQPPLAKMDGADLRSFLGSWY
                     DIVAAALGLEARDPVPVPDPTGVREGLDWVMTRLTVKKAPVVLLLDDLHWADAESLNWL
                     SSFAQRVEDLPLLIVLAYRPDELPPEAEELRRLVGRHGGRPHALDRLTADGVARIVRHE
                     VGEEAEDRFCKECWSATGGSPFEAVELAFELGERKLRGAEGDLPAMRELAAAVKGPGLI
                     ERLEGLDTSTVRFAHIAAVLGSPFSPQLAATIAVLGDEAVAEATQQLRAARILADGHGP
                     GGELEFVHPLIATTIYRSIRSAFRVGLHNAAAEAVLAAGYGPTAAARHLLEVPCEGNPE
                     AVACLREAAGEYLRAGATEAARRLLTRALQEPPLPEDRAAILHELACSTFLIEPTATVR
                     YLRQALAEPDVDPDLRASIVYRLTQALAHTDQLAEAVTVAAEEARQATNPRVKLRMQAD
                     HFVWSMVRTDDPDSPARSRTLTRLAEQLPGRRLEERYILGLRAWDAVKRGEPRQTALAY
                     AEKALRGGMSWTDENRGFEVPVSVALVFMYGDQPRRAEELFNKDIEECAAKGWRGSHLA
                     FGQTLAGYIRYRRGCLAEAEDRVREGLRIADKVEGAVPAQWFAVGILIKTLLARGRIAE
                     ARALADEHHFGEMTPNAVIYPDPRTVYAELLLAEGRHAEAAALLSLVGDWLDQRAWRNP
                     AWCPWQLRLASALAPTAPDEAVDHAQEAVKRARDFGAASTIGQSLHTLAEVTGGPAALD
                     LYAEAVEHLEQSPSSYELARALVGHGASLSRNGRLQEAADRLYQGLEGAVHCGAEALAA
                     RAREELSGAGLRPLPLRYVQADTLTAQERRTAELTVQGQPVAVVAKELRLTEQGVRHLL
                     SSVYRKIGTDASGLALCLESVPRHRA"
     gene            complement(14051..15604)
                     /locus_tag="EHO50_RS10990"
     CDS             complement(14051..15604)
                     /NRPS_PKS="Domain: AMP-binding (8-412). E-value: 5.9e-76.
                     Score: 247.6. Matches aSDomain:
                     nrpspksdomains_EHO50_RS10990_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138525.1"
                     /locus_tag="EHO50_RS10990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA synthetase"
                     /protein_id="WP_128429700.1"
                     /sec_met_domain="AMP-binding (E-value: 7.7e-79, bitscore:
                     261.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTPPAGFWAQAAADPDRTVLVAPDGEEWTAGRLHAAANRLVHG
                     LRAAGMERGDAFAVVLPNSAEFFTAYLAASQAGFYLVPINHHFVGPEIAWIVADSGAKV
                     LLAHERFAAPARHAADEAGLPGTHRYAIGTVEGFRPYAELLDGQPESAPADRELGWVMN
                     YTSGTTGRPRGIRRPLPGKVPEEAYLGGFLGIFGIRPFGDNVHLVCSPLYHTAVLQFAG
                     ASLHIGHRLVLMDKWTPEEMLRLIDREKCTHTHMVPTQFHRLLALPEEVRARYDVSSMR
                     HAIHGAAPCPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISE
                     LAIFDDDGNRLPPGELGTVYLKMNTGGFAYHKDEAKTRKNRIGDFFTVGDLGCLDEDGY
                     LFLRDRKIDMIISGGVNIYPAEIESALLAHPAVADAAAFGIPHDDWGEEVKAVVEPAHG
                     HEPGPDLAAAILDHCAEQLAGYKRPKSVDFITEMPRDPNGKLYKRRLRDPYWKGRSRPV
                     "
     aSDomain        complement(14369..15580)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EHO50_RS10990_AMP-binding.1"
                     /evalue="5.90E-76"
                     /label="EHO50_RS10990_AMP-binding.1"
                     /locus_tag="EHO50_RS10990"
                     /protein_end="412"
                     /protein_start="8"
                     /score="247.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FWAQAAADPDRTVLVAPDGEEWTAGRLHAAANRLVHGLRAAGMER
                     GDAFAVVLPNSAEFFTAYLAASQAGFYLVPINHHFVGPEIAWIVADSGAKVLLAHERFA
                     APARHAADEAGLPGTHRYAIGTVEGFRPYAELLDGQPESAPADRELGWVMNYTSGTTGR
                     PRGIRRPLPGKVPEEAYLGGFLGIFGIRPFGDNVHLVCSPLYHTAVLQFAGASLHIGHR
                     LVLMDKWTPEEMLRLIDREKCTHTHMVPTQFHRLLALPEEVRARYDVSSMRHAIHGAAP
                     CPDHVKRAMLDWWGPCVEEYYAASEGGGAFATAEDWLKKPGTVGKAWPISELAIFDDDG
                     NRLPPGELGTVYLKMNTGGFAYHKDEAKTRKNRIGDFFTVGDLGCLDEDGYLFLRDRKI
                     DMIIS"
     CDS_motif       complement(15080..15115)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EHO50_RS10990_0001"
                     /evalue="4.90E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="EHO50_RS10990"
                     /protein_end="175"
                     /protein_start="163"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YTSGTTGRPRGI"
     gene            complement(15601..16725)
                     /locus_tag="EHO50_RS10995"
     CDS             complement(15601..16725)
                     /EC_number="1.13.12.-"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004003890.1"
                     /locus_tag="EHO50_RS10995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="nitronate monooxygenase family protein"
                     /protein_id="WP_128429701.1"
                     /transl_table=11
                     /translation="MQTELSKKLGVEHAIFGFTPFPAVAAAISRAGGFGVLGAVRYTAP
                     DDLKRDLDWIEAHVDGRPYGLDVVMPAKKVQAPNNQTLTEADVEAMIPEGHRQFVNDTL
                     AKYGVPELAEGEASGWRITGWMEQVARSQLDVAFDYPIKLLANALGSPPADVVERAHDR
                     GVLVAALAGSARHAVKHKEGGIDIVVAQGYEAGGHTGEIASMVLTPEVVEAVDPLPVLA
                     AGGIGSGQQVAAALSLGAQGVWLGSIWLTTTEAELPSPRLIQKLLAAGSGDTVRSRALT
                     GKPARQLRTEWTDAWDDTNGPGTLPMPLQGLLVAEAVSRIQKYEVEPLLGTPVGQIVGR
                     MNSERSVQAVVDDLTRGFEQAVDRINRIAGRSGQ"
     gene            16962..18731
                     /locus_tag="EHO50_RS11000"
     CDS             16962..18731
                     /EC_number="3.1.1.103"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007379876.1"
                     /locus_tag="EHO50_RS11000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_128429702.1"
                     /transl_table=11
                     /translation="MTDDRSRLTRRQLGRTALVLGGALAITPFPVGPAIAASSSGRSTL
                     RHGSPERAGLLPAHLHRLVTDAETFLDPSPKHPWYAGAVLLAGRGGTVALHQPIGMALR
                     YQAYDEKTDTGVEFPPDQQIPMAEDTVFDLASVSKLFTSILAVQQIERGALGLEATVAS
                     YLPDFGSAGKQDITIRQLLTHTSGFRAWIPLYNAPTYEEKLQLIWNEAPLNAPGTKYLY
                     SDLNLISLQLVLEKITGRELDILLRDEITAPLGMRYTRYNPPAAWKPKIAATEDARRPW
                     SGLDRGLVWGEVHDENAFSLGGVAGHAGVFSNAWDLAVLGRTLLNGGAYGRSRILEPES
                     VELMFTDFNTAFAGDEHGLGFELYQHWYMGAMATPRTAGHTGFTGTSLVLDPTTDSFLV
                     VLGNSVHPVRSWRSGSAPRVAAADHMARAVPVRPRHGRTAWFSGMASATTATLALPALD
                     TTCGDVRLRCALWWDTEPQSDALTLESTTDGGTTWQQLPFTTTRHGERPQDHPTGTVNG
                     WSGRVWHRLTAQLPAHRQLVIRWRYTTDRLYVGRGAYVDGLRVETPATVLFDEARPADA
                     ARIEATGWAASAD"
     gene            complement(18744..20021)
                     /locus_tag="EHO50_RS11005"
     CDS             complement(18744..20021)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019073051.1"
                     /locus_tag="EHO50_RS11005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_246101107.1"
                     /transl_table=11
                     /translation="MIAAAALPLYLTMIAASAGALVDTALLGNHATATLAAFAVAMAVF
                     SPATATVAGALRGVMPFVTPSKEDPDRLLPVVRSGTWLAITVGAIAAAAVASVPLIGRA
                     AEVPRTTLDQLGMFPLLLAGSVLAIAVSSSATSVLVALGHSKSVMRAGLLGTAASTMLS
                     VLLVGAPGPLPSYGLTGAGIAMLASSVVSACVNQVAISRSTVLSGHSLYPGRPDVKQVW
                     ALGTVGIPLAGTVLVKFAVLGVLTFAAARMGTDSAAVHSVGISLVNLIFTAAVAVGQAT
                     VPLISDYATKHDSARIRRSVRAGTWLALAVVGSIAATVIALSSWVVPLFTQDVDVRPQI
                     TDLLPLVLVVVVTDALQAVVGFGLIGLKRTVPSFVSTFICYGGLAAVAAPVATTGGLTA
                     LWTALALANLLQAVSKAYSFHRHSTD"
     gene            complement(20211..20351)
                     /locus_tag="EHO50_RS11010"
     CDS             complement(20211..20351)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EHO50_RS11010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_246101108.1"
                     /transl_table=11
                     /translation="MRQSLGRSRGGLTTKLHLAVEQGQKPMSIVITAGQRACHSRTSVQ
                     P"
ORIGIN
        1 gtagcaggac gcgccggtga gcgggtggtc tccctacggt cgcaatgacg gtcgtcgaga
       61 ccgcaggacc gaaagggagc gcccgtgaag cgacgcatcc acgcgatatg cgcagccgcg
      121 atcaccgtcc ttgtcaccgc aggcccggcg agcgacatcg cccacgcccg gaacgacatg
      181 gactgcagcg acttcgcctt ccaggaagac gcacaggcgg agttcaaccg cgatcccgac
      241 gaccaccatc gcctggacga ggaccgaggg aggcacgacg gcatcgcctg tgaggtcctg
      301 ccccaccgca acgcggccgt ctccacgccc ctccccatac gctcgccgat ccccacactc
      361 tcgcccctcc ccacacaggg agtcaggggc ggcctgggcg gtagcacggg accggcgagc
      421 ttcgaggtgg ctctgggagc cggcctggcc gtcggtgcgg tggctctgac cgccgggtac
      481 ttcgtgtacc ggcgccggtt cagccgctga ggcgcacctg ctgtccggcg gaccgcccct
      541 gactgtccgt agccgatgtg tggccctccc atacggcggc cgcagaccgg caacccccgg
      601 ccataccagg caccacgtgg ccctcgctca cgttcggggc cgaccgacga cgtcctggtc
      661 ctccaccaca tcgtgcggtg cgtccgccga cgggtcggcc tcgaccacgg cctcgctcgc
      721 cgtggatgct gagcgccccg gcgcacgcct gcccagacgc tccgtcagac gggttgccag
      781 gggctcggtg tagcgggcgg tcagcgggcc caggaccacc aggatcagta cgtagccagt
      841 ggccagcggg cccagtgacg gctcgatgcc ggcggtgacg gcgagcccgg cgatgacgat
      901 ggagaactcg ccgcgggcga ccagcgtgcc gcccgcacgc cagcggccct tcgcggagat
      961 cccggcgcgt ttggcggccc agtagccggt ggcgatcttc gtgagcgcgg tgacgacggc
     1021 cagggcgagc gcgggaagca gcaccggcgg gatgctcgcg gggtcggtgt gcagaccgaa
     1081 gaagacgaag aacacggcgg cgaacaggtc ccgcagcggc gccaggaggt ggtgcgcacc
     1141 ctcggccacc tcaccggaca gcgcgatgcc gaccaggaac gcgccgacgg cggcggagac
     1201 ctggagctgc tgggcgagtc cggccacgac gagggtcagg ccgagcacga cgagcagcag
     1261 cttctcgggg tcgtcgctgg agacgaaccg ggagatgtgg cggccgtagc gcaccgcgag
     1321 caggaggacg agtcccgcga cgccgagcgc gatggcgagc gtgacgcttc ccgcggcgag
     1381 acctgcaccg gcgagcaagg cggtgacgat cggcaggtag acggccatgg agaggtcttc
     1441 caggaccagg atgctcagga cgaccggggt ctcgcggttg ccgagccgcc cgaggtcgcc
     1501 gaggaccttc gcgatgacac cggaggagga gatccaggtg acgccggcca gtacgacggc
     1561 ggcgaccggg ccccagccga gcagcagcgc catggcggca ccgggcaggg cgttgagcgc
     1621 ggcgtcgagg agaccggccg ggtactgggt cttgaggttg gagaccagat cgctggccgt
     1681 gtactcgagg ccgagcatga gcagcagcag gatcacaccg atctcggcgc cgatggcgac
     1741 gaagtcctcg ctggtgccca ggggaagcag accgccctcg ccgaaggcca gcccggccag
     1801 caggtacagg gggatcggcg agaactggaa ccgcccggcg aaccggccca gcagacccag
     1861 ggcgaggatg atcgcgccga actcgatgag gaagaccgcg gaggagtgca tcgcggctca
     1921 ctcccgtccg agtatcgcgg cggccgcctc cacaccctcg cgggtgccga tcacgatcag
     1981 ggtgtctccg ccggacagcc ggaagtccgg cgtcggcgag gggatggcct cggcgcggcg
     2041 cagcacggcc acgatggaca cgccggtctc ggtgcgcatc cgggtctcgc cgagcagccg
     2101 tccgttccag tgcgacgtgg cggacagctc gacccgctcg gcgacgaggc ccagttcggt
     2161 ggtggacagc aggttggggc tgtggtgcgc cggcatcaac gcgtcgatca gcgtggccgc
     2221 ctcacccgag gtgagccgca ccgacagcgc acaggcgtcc ggatcgtcct tgcggtacgc
     2281 gctcagcgtc cgcgatccgt cccggtgggc gaccaccgac aggcggcgct gttcgcgcgt
     2341 ggtgaggtcg tagcggaccc cgatgccggg caatggcgta ctgctcaggc gtggagcgcc
     2401 cacagctgtc ccccctcgtt gaggtccctc ttccagctct ctttgacgaa actttaacga
     2461 ccggcgagca gccgggccga tccagcccgt tcgacggcga ggacgaggac ggggcggcga
     2521 gtcgggagag cgcggagcgg gtgtgggctg gtcccatgtg ggcgcgcctc atgtgggcca
     2581 gccccatgtg ggcccgcaac acgtcgacgt cgtccacaag atggtcgcag cggtacgtgg
     2641 gctggatcca ccggcaccga ggagtccccg gtgccacgca ggtccgaggt gctccattct
     2701 gaacggcgcc actcgcagaa agtacgagcc acccccttgc ctgatcattc gccgcctgga
     2761 ttactgatcc cgaacagccg gaccgaatga tcggtcgccc ggattgatgt ggttggcgag
     2821 ggagaactcc ccatggcgga tgcgacggag ctgctggact cgggggaacg gctcggcccg
     2881 gaggcgttgc gggcgttgca gctggagcgg ttgcggacgt cacttcggca cgcgtacgac
     2941 aacgtgccgt tctaccggga gtccttcgac aaggcaggcg tacggcccga cgactgccgt
     3001 tccctcaccg atctggcccg cttcccgttc acgaccaagg ccgacctgcg cgagaactac
     3061 ccgtacggga tgttcgccgt gccccaggac cgtgttcgcc gcatccatgc ctccagcggc
     3121 accaccggac gtcccacggt cgtcggctac acggacgccg acctttccct gtggtccgac
     3181 atggtggccc gctcgatccg agcggcgggc gggcggcgcg gggacaaggt gcatgtggcg
     3241 tacggctatg ggctgttcac cggtgggctc ggcgcacact acggtgccga acggctcggt
     3301 tgtacggtca tccccgcgtc cggcggtatg acggcccgcc aggtccagct gatccaggac
     3361 ctcaggcccg agatcatcat ggtgacgcct tcgtacatgc tcactctcct cgacgagttc
     3421 gagcggcagg gcgtcgatcc gcgcggtacc tccctgcgtg tgggcatctt cggtgccgag
     3481 ccctggacgg agcagatgcg tcaggagatc gaggagcggt tcgcgatcga cgccgtcgac
     3541 atatacgggc tgtccgaggt gatcgggccg ggggtcgcgc aggaatgtgt ggagaccaag
     3601 gacgggctcc atgtgtggga agaccacttt ttgcccgagg tcgtcgatcc gatcactggt
     3661 gaggtgttgc cggacggcga ggagggcgag ctggtcttca cctcgctcac caaggaggcc
     3721 atgcccgtca tccggtaccg cacgcgggat ctgacgcggc tcctgccggg caccgcccgg
     3781 gtgttccggc ggatggagaa gatcaccggg cgcagtgacg acatggtcat cctgcgcggg
     3841 gtcaatctct tccccacaca gatcgaggag atcgtgctcc ggacacctgg ggtggcgcca
     3901 cacttccagc tgcggctcac ccgggagggc cgtctcgacg ccctcacggt gcgggcggaa
     3961 gctcgccgcg acgcgtcgcc cgagacgagg gacgccgccg cgcaggccat cgcggcggcc
     4021 gtgaaggacg gcatcggggt gtcggtcgcg gtggagatcg tcgaaccgga gtcgctggaa
     4081 cggtccgtgg gcaagatcag gcggatcgag gacctgcggc cccgctagcc gcagccgctg
     4141 ccgaaccggc ctcggctagt caccggcgaa ccggtcccgc agctcccgct tgaggatctt
     4201 cccgctcgcg ttgcgcggca gctcgtccac gaacaccacc cgcttgggcg ccttgaagtg
     4261 ggcgagcttc tcgcgcgcgt actcgatcag ttcggcctcg gtcacgccgc cgcgtgggac
     4321 gacgaccgcc gtgatcgcct cgatccaccg ttcgtcgggc aggccgatga cggccacctc
     4381 gccaacgccc tcgtgcgtgt acagcgcgtc ctcgacctgg cgcgaagcca ccagtacgcc
     4441 accggagttg atgacgtcct tcacccggtc gacgatggtg aagtagccgt gcgcgtcccg
     4501 caccgcaagg tcgccggagt ggaaccatcc gtcccggaag gcctcggcgg tctcctcggg
     4561 cttgtcccag tagccctcgc acaactgcgg ggagcggtag acgatctcgc cgggcgtgcc
     4621 gtcgggcacg tcctcgccgt cctcgtcgac cacacgggcg tcgacgaaga ggacggtgcg
     4681 gccgcaggag tccatgcggc ccttgtgttc gtccggggcc agcacggtgg ccagcgggcc
     4741 gatctcgctc tggccgaagc agttgtagaa ggcgagcttg ggccaccgct cacgcagccg
     4801 ctccagtacc ggcaccggca tgatcgacgc gccgtagtac gccttgcgca gtccatccag
     4861 gtcgcgggtc gcgaagtcgg gtcggttggc caggccgatc cacacggtgg gcggcgcgaa
     4921 cagactgtcc gcgcggcccg cttcgatcag atcgaagagc tgctcgccgt cgggcccgtc
     4981 caggatgatg ttcgtggcgc cgaccgccag gtacggcaag aggaacacgt gcatctgcgc
     5041 cgagtggtac agcggcagcg agtggacggg gcggtcgccg gcgctcagat cgagggcggc
     5101 gatcgcgctc aggtactcgt ggaccagggc gcggtgggtc atcatcgcgc ccttgggcaa
     5161 ggcggtcgta cccgaggtgt agagcagttg caccaggtcc tcgctgcgcg gctccgggcc
     5221 gtcgtaggcg gacgccgtgg cctgccgcgc cagcagtgag tcgtcggcat cgcgcaacgg
     5281 caacgtacgg acaccgtccg ggaggcggtc cgccaggtcc gggtccgcga ggaccaggga
     5341 gctgccggac tggccgacga tgtacgcgag gtcgtcgccg gtgaggttct ggttgacggg
     5401 gacgtggacg aggcccgcgc gggcgcaggc gaggaaggcg atgagatagg cgtccgagtt
     5461 gtgtccgtag gcgccgaccc ggtcgcccgg ggtgaggccc tggtcgagca gcacgcgcgc
     5521 cgcgcgcgat acggcctcgt cgagttcctc gtacgtccag gagcggtcgc ggtggtcgac
     5581 cgcgacgcgc gccggggtgc gtcgggcact tcggcgcagt actccgtcaa ccgtgctgcc
     5641 gtgtcctggc gtcatgacac atgatcctcg gtgtgtcgca cggacaggtc aagcaggacg
     5701 gcacgagact gcaccggggg cacatacccg ttggtacgct caacggttcc ttccctcaat
     5761 gacgttggga ggcacgatgc gcacccgccc cagacggctc gtcgtcgcgg ccgtcgccct
     5821 gctcgccgcc acggccggac tgcccgcgac cgcggccgaa cgacaggacc ggaacgacag
     5881 tcagggccgg caggacctgc acgaacagct ctcgcacggc ggcctgtccg ccgacgtccg
     5941 ctataccgag tacggcattc cgcacattgt cgccaaggac tacaagtccc ttggtttcgg
     6001 aaccggttgg gcgcaggccg ccgaccaggt gtgcacgctg gccgacgggt tcgtgaccgt
     6061 gcgcggcgag cgctcgcggt tcttcgggcc ggacgcggcg accgacttct cgctgtcctc
     6121 ggccaccaag aacctctcca gcgacctgta cttccgaggc gtacgccaga cgcgcacggt
     6181 ggagaagctc ctcgccgagc cggcaccgcg cggtccgagc cgtcaggtca aggacctcat
     6241 gcggggcttc gcggccgggt acaacgcctg gctgaagcag aaccgggtca ccgaccccgc
     6301 gtgcaagggc gccgcctggg tgcggccggt cacctcgctg gacgtggccg cccgcttcta
     6361 cgccatcacc gtgctcggcg gccagggcgg cgcggtggac gacatcacga gcgcccagcc
     6421 gcccaccacc ggatcagccg ccatggcccg gggcaccggg accggtccga gtgccgcggc
     6481 cctcatccgg gccgtgcgcg agcggacggc cgacgcgggc atggggtcga acgcggtcgc
     6541 cctccgtggc gacaccacag caacaggccg aggcctgttg ctgggcaacc cgcactaccc
     6601 gtggcacggc ggacgccgct tctggcaggc gcagcagacg attcccggcg agctcgacgt
     6661 ggccggtgct tcgctgctgg gttcaccgac gatctccatc ggctacaact cacatgtggc
     6721 gtggagccac actgtttcta cgggcgtccc gttcaatctg caccgtctga ccctggatcc
     6781 ggccgacccc accgtctatg tggtggacgg tgaatccgag cggatgaaga agcggaccgt
     6841 gaccgtcgcg gtcaagggcg gcgcaccggt gacccgcacc cagtggtgga cccggtacgg
     6901 cccggtggtc gcctccgccg acggcgagct gccgctgccc tggaccgcgt cgacggcgta
     6961 cgcgatcaat gaccccaacg cggccaacat gcgtttcgcc gacacctcgc tcggtttcag
     7021 caaggcgcgc ggcaccgccg acgtcctcgc ctccctcgcc cggcaccagg ggctcccgtg
     7081 ggtgaacacc gtcgccgcgg actcctcggg gcattccctg tacacccagt cgcaggtgct
     7141 gccccggatc accgacgacg tcgcggcgcg gtgttccacg gacctcggca aggtcaccta
     7201 cccggcggcg ggcctcgcgg tcctcgacgg ctcccggggc gactgcgccc tggggcgcga
     7261 caccgacgcc gtccagcccg ggaccttcgg gcccgcgcac atgcctacgc tgaaggacgc
     7321 gccgtacgcg gagaactcca acgacagcgc gtggctggcc aacgccgacc ggccgctcac
     7381 cggatacgag cggatcttcg gcaacatcgg cacccagcgc tcgctgcgca cgcgtggagc
     7441 gatcgaggac gtggcggcgc tggccgagcg gggcgggctg accgtccggg atctggagcg
     7501 gcagcagttc gcgaaccggg cgcccgcggc cgacctggcc gcgaccgaca cggcgacggc
     7561 gtgcgccgcg ctgccgggcg ggacggcaac aggaagtgac ggcaaggccg ttgacgtcac
     7621 cgaggcctgt tcggtgctcg cgggatggga tcgcaccatg gacaccggca gccggggcgc
     7681 cctgctcttc gaccgattct ggcgaaagct gacggcgaag gtgccggccg cgcagcgctg
     7741 gaaggtgccc ttctcggcgg cggacccggt gcgcacgccg aacaccctca acaccgccgc
     7801 ccccggcttc gccgcggccc tcgcggacac ggtcgccgaa ctccgggcga cgggcatcgc
     7861 cctcgactcc cgcctcggtg agcaccagtt cgtcgtacgg aacggtcagc gcgtccccgt
     7921 tccgggtggc acggaggggc tgggcgtgtg gaacaagatc gagccggtgt ggaatccggc
     7981 gggcggcggc tacgcggagg tgacgaccgg atccagctac atccaggccg tgggctggga
     8041 cggcggccgc tgcccggtgg cccggacgct gctgacgtac tcgcagtcct cgaacccgag
     8101 gtcggcccac ttcagcgacc agacccggtt gttctcgggt gagaagtggg tgaccgcgcg
     8161 gttctgagag aaggacatcc tgtcgtctcc cgccctgaag gtcgtccacg tacgcgaacg
     8221 ctgagcgact gtggtcccgt cccacatggg gcgggaccac atagggcggg gccacatggg
     8281 gcggaaccac atctgagtga caggtgaaat tcgcctatcg ccgtacgatg catcaactac
     8341 ccctggccga atgcttcctt tgcttctccg tgcccctgtg cgcccctttg gagaaaggtt
     8401 tccggaaacc gattgctgct tgaactgggc aggacttgtc tcaagtgtca agtccgtggc
     8461 acgttcaccg attttttgcg tgtcacatca ggcaggaggt ttcccatgag ccgtgctgtg
     8521 cctgaacagg agcgagtatg gcggacaggt actgctccag gcatattccc catcctcggt
     8581 cacggtatcg cgttgttccg tcaaccgctg gtgtttctga attctttgcc ctcgtacggg
     8641 gatctggtcg agatacggct gggcccccag cgcgcctgga tggtgtgtca cccggagctg
     8701 gtccacgaga tgctcaagga tccccacacc ttcgacaaag ggggcccgct ctacgacaag
     8761 ctcgggaagc tgatgggcga cggtctcgtc acctgccgcc aaccggcgca tcgggaaaaa
     8821 cgcaggctgc tgcaaccagg ttttcgccct tcccacgtcg ccacctacgc gaacctggtc
     8881 ggtgaggagg ccgagtcggt gtgccaggcg tggtctgccg ggcaggcggt ccgcgtcagt
     8941 gacgcgatga tggcgctgac gacccgggtg atcagccgtg ttctcctctc cgactcactc
     9001 gacgacgcca cgtccgccga ggtgcgggac tgtctcaccg tcatcgtccg tggcctgttc
     9061 gtccgcacgg ccgtgccgat cgacgccctg ttccgccttc ccactcccgc caaccgccgc
     9121 tatctgcgcg cggtcgaccg gctgcacacg atcatcgacg ccgccatcgc ggaccgtcgc
     9181 cggggtgcct cccacgacga tgtgctggga accctgttcg cggccacgcg gggggagggc
     9241 ggaacgccgg cgatcaccga ccaggaagtc cacgatcacc tgatcacgct cctgctcacc
     9301 ggtgtcgagg cccccgcgct gtgcctggcc gacgccttca gcctgctggc ccgccatccg
     9361 gtggcggaac gccgtctgca cgccgagctc gacgccgttc tccccggagg tcgccggccc
     9421 ggccccgacg atctgccgca cctcgtctac acccggtgcg tcgtctccga gacgttgcgc
     9481 cacacctcgc ccggctggct cttcacccgc ctcaccacca aggagacgga actcgccggg
     9541 tgccgcctgc cgcagggcgc caccgtcctg tacagcccct atctcctgca ccacgacgcc
     9601 tcgtcgttca ccgaacccga tcgtttcctc cccgaccgct ggttgccggg gcaggtcacc
     9661 gccgtacagc gccgcgcgat gatgccgttc tccgcaggca gccgcaaatg tctgggagac
     9721 gagttctcca tggtggaggc cacactggcg ctcgcgacca ttgccgggcg ctggcggctg
     9781 cgccatctgc ccgggcatgt cgaacccaaa ccgcgccccg cgatcactct ggggccgcgc
     9841 accctggtca tggactgcga acccagggcc acacatcgcg tatcggattc ctggacggca
     9901 ggtggcaacg gtgtcgacaa cgcatgagga aatcacggtc ggtgtgcaaa acggaactcc
     9961 ggttccccat ctcaaggaac tgatcgacac ccacctccac atgcccttcc cattcatgcg
    10021 gaatcgccat gaatccgcag tcacggccgg cgtcgacgca tggttggccg tgtggggtct
    10081 gaccgacgat ccggaggtgg cgtcgatgat cgcccgcacg cgccccgccg agctcgcctc
    10141 ctacaactgc cccaccatgg attccggtct cctccagatc gtggccaatc agatcgccta
    10201 tcaattcgtc ttcgacgacc gggcggagga aatcggccgg cactctccgg gtctgctcct
    10261 gcccatgctc ttcgagagca tcgcaattct gcgggacagc cgacagccca gcactccgct
    10321 cggcgcggcc ctggccgatc tccaccggca ggtccgggaa cggtgcacgc cggcccaggc
    10381 cgcccggtgg gcgtggaaga gccgtgagta cgtgcacggc ctgttgtacg aagcggtcgc
    10441 acaggccgac cccctccccc tgcggaccgg gcactgcacg tcgatacggt cactgaccgc
    10501 gggcgtcgag ccgttccatc cgctgtgcga ggccgcccag ccgcacgagc tgagcctcgc
    10561 cgaactccac caccccgtcg tacgccgact gggccggttg tccgccgacg ctgcggtgtg
    10621 gatacccgac ctgttctccg cggtgaagga acaacgcgca ggcggaatga tcaacctggc
    10681 cctcgcgcac cagcgcgaac agcgctgctc gctgccggcg gccgtcatgc tggccatccg
    10741 gcagatcaac ggcacgatca aggagttcca ggggctctac gcgcaggtcg aaccggagtt
    10801 gagcccctcg ggcgtcggct atgtggaggg catgatcggc tggatccgcg gctgttacta
    10861 ctggtcccga accgtgccgc gctacgcgga tgcggcgtgt gtgtcggcgc tcccgtgacg
    10921 gccgccgtca cggggcggtg aaaaggctcc cgggaagggg cccatccgaa tttcctaccc
    10981 gagaaacggg ctttctcatt cccctcgatc catgattcat ccattggtgc acattccggc
    11041 ctgccgtacc tccaggaggc gtacgctcgg ctgctccgag gccgaactac tgaaggcggt
    11101 acggcacatg gcgaaggagc cgcggccccc ggtcaccgag caagggatgt tgatcgagcg
    11161 gcagcgggaa cttcatgccc tcgacgccgc gttcaaggaa ctgcggcaca ccacggacgg
    11221 cgttccgcgg gcgcggcgca gggggctgct ggccttcacc gggtcggccg ggctgggcaa
    11281 gaccgctctc atcagggctg cccgctcccg ggctgcggcg cacgggttca ccgtgctctc
    11341 gggccggggc ggtgagaagg aacaggggct ggcgttccgc gtggtgcgcc agctcgtgca
    11401 gcctccgctg gcgaagatgg acggggcgga cctccgctcc ttcctgggca gttggtacga
    11461 catcgtcgcc gccgcgctcg gtctcgaggc gcgcgacccc gtccctgtgc cggacccgac
    11521 gggggtccgc gaaggcctcg actgggtcat gacgcgtctc acggtgaaga aggcgcccgt
    11581 cgtgctgctc ctggacgacc tgcactgggc ggacgccgag tccctcaact ggctctcctc
    11641 cttcgcgcaa cgggtcgagg accttccgct gctgatcgtg ctcgcctacc ggcccgacga
    11701 actgccgccc gaggcggagg agctccgcag actcgtcgga cgacacgggg gccgtcccca
    11761 cgccttggac cggctcaccg ccgacggagt ggcgcggatc gtcaggcacg aggtcgggga
    11821 ggaggccgag gaccggttct gcaaggaatg ctggtcggcc accggcggga gtcccttcga
    11881 ggcggtggag ctcgccttcg aactcggcga gcggaagctg aggggcgccg agggcgacct
    11941 gcctgcgatg cgtgagctgg ccgcggcggt caagggcccg gggctgatcg agcgtctcga
    12001 agggctcgac acgtcgaccg tccgcttcgc gcacatcgcg gccgtgctgg gttcgccctt
    12061 ctcaccgcag ctcgccgcga cgatcgcggt gctcggcgac gaggccgtcg ccgaggcgac
    12121 ccagcagttg cgcgccgccc ggatcctggc cgacggtcat ggtcccgggg gtgagctcga
    12181 gttcgttcac ccactgatcg ccaccacgat ctaccggtcc atccgctcag ccttccgggt
    12241 cggtctgcac aacgccgccg cggaggccgt cctggccgcg gggtacggcc ccaccgccgc
    12301 cgcccggcac ctgctggagg tcccctgcga gggcaacccc gaggcggtcg catgtctgcg
    12361 cgaggcggcc ggtgaatacc ttcgcgccgg ggcgaccgag gcggctcggc gtctgttgac
    12421 ccgtgcgctg caggagccgc cgcttcccga ggaccgtgcc gcgatccttc acgagctcgc
    12481 gtgctccacg ttcctgatcg agcccacggc caccgtgcgg tatctgcgcc aggcgctggc
    12541 ggaacccgac gtcgaccccg atctgcgcgc ctccatcgtc tatcggctga cgcaggctct
    12601 ggcccacacc gatcagctgg cggaggccgt gaccgtggcg gccgaggagg cgcggcaggc
    12661 cacgaatccg cgcgtcaaac tgcgtatgca ggccgatcat ttcgtctgga gcatggtccg
    12721 caccgatgac cccgactcgc ccgcccgttc ccggacgctg acgcggctgg ccgagcagtt
    12781 gcccggtcgc agactggagg agcgctacat cctggggctg cgggcctggg acgcggtgaa
    12841 gcgcggcgaa cccaggcaga ccgccctcgc ctacgccgag aaggccctgc gcggcggcat
    12901 gagctggacc gacgagaacc ggggtttcga ggtacccgtt tcggtcgccc tggtgttcat
    12961 gtacggcgac cagccgcgac gggccgagga gttgttcaac aaggacatcg aggagtgcgc
    13021 ggccaaaggc tggcgcggct ctcacctcgc cttcggccag accctcgccg gctacatccg
    13081 ctaccgccgc ggctgcctgg ccgaggccga ggaccgcgta cgggaggggc tgcgcatcgc
    13141 cgacaaggtg gaaggggcgg tgcccgccca gtggttcgcc gtcggcattc tcatcaagac
    13201 cctactggcc cgtgggcgca tcgccgaggc gcgcgcactg gccgacgagc accacttcgg
    13261 ggagatgact ccgaacgccg tcatctaccc cgacccgcgc accgtgtacg cggagctgct
    13321 cctggcggag gggcggcacg ccgaagcggc ggcgctgttg tccttggtcg gggactggct
    13381 ggaccagcga gcgtggcgca atccggcctg gtgcccgtgg cagctgcggc tcgcgtccgc
    13441 gctcgcgccc accgcaccgg acgaggcggt cgaccacgcc caggaggccg tcaagcgagc
    13501 ccgggacttc ggcgccgcct ccaccatcgg ccagtccctc cacaccctcg ccgaggtgac
    13561 cggcgggccg gcggcgctcg acctgtacgc ggaggccgtc gagcacctgg agcagtcacc
    13621 gtcctcgtac gaactcgccc gcgccctggt cggccacggc gcctcgctgt cccgcaacgg
    13681 gcggctccag gaggccgccg atcggctcta ccaaggcctg gaaggcgccg tccactgtgg
    13741 ggccgaggcg ctcgccgccc gggccaggga ggaactgtcg ggggccggtc tgcgcccgct
    13801 gccgctgcgg tatgtgcaag ccgacacgct gaccgctcag gaacgccgta ccgccgaact
    13861 gaccgtccag ggccagccgg tggcagtggt cgccaaggag ctgcgtctca ccgagcaggg
    13921 cgtgcggcac ttgctgtcct ccgtctaccg caagatcggc accgacgcca gcggcctcgc
    13981 cctgtgcctg gagtccgtgc cccgccatcg cgcctgaaac cgccggcccc ggatcccgtg
    14041 tcggccgcgg tcacacgggg cgtgagcggc ccttccagta cggatcccgc aaccgccgct
    14101 tgtacagctt cccgttggga tcgcgtggca tctcggtgat gaagtcgacg ctcttgggcc
    14161 gcttgtagcc ggcgagttgc tcggcacagt ggtcgaggat cgcggcggcg aggtcggggc
    14221 ccggctcgtg gccgtgggcc ggttcgacga cggccttgac ctcttcgccc cagtcgtcgt
    14281 gcgggatgcc gaaggcggcg gcgtcggcga cggccgggtg ggcgaggagc gcggactcga
    14341 tctcggccgg gtagatgttg accccgccgg agatgatcat gtcgatcttg cggtcgcgca
    14401 ggaagaggta gccgtcctcg tcgagacagc cgaggtcgcc gacggtgaag aagtcaccga
    14461 tgcggttctt cctcgtcttg gcctcgtcct tgtggtaggc gaagccgccg gtgttcatct
    14521 tcaggtagac ggtgccgagt tcgcctggcg ggagccggtt gccgtcgtcg tcgaagatcg
    14581 cgagttcgct gatgggccag gccttgccga ccgtgccggg cttcttcagc cagtcctcgg
    14641 cggtggcaaa ggcgccgccg ccctcgctgg ccgcgtagta ctcctccaca catgggcccc
    14701 accagtcgag catcgcccgc ttcacatggt cggggcaggg ggcggcgccg tggatggcgt
    14761 gccgcatgga ggagacgtcg tagcgggcgc gcacctcctc gggcagggcg agcaggcggt
    14821 ggaactgggt cgggaccatg tgtgtgtggg tgcacttctc acggtcgatc agccggagca
    14881 tctcctcggg cgtccacttg tccatcagca ccagacggtg gccgatgtgc agggacgcgc
    14941 ccgcgaactg gaggacggcc gtgtggtaga gcggcgagca gacgaggtgc acgttgtcgc
    15001 cgaacgggcg gatgccgaag atgccgagga aaccgcccag gtacgcctcc tcggggacct
    15061 tgcccggcag cgggcgccgg atgccgcgcg gtcggccggt ggtgcccgag gtgtagttca
    15121 tgacccagcc gagctcgcga tccgcaggcg ccgactccgg ttgtccgtcg aggagttcgg
    15181 cgtacggcct gaagccctcg accgtgccga tcgcgtaccg gtgggtgccg ggcaggccgg
    15241 cttcgtcggc ggcgtgacgt gcgggggcgg cgaagcgttc gtgggcgagg agcaccttgg
    15301 cgccggagtc ggcgacgatc caggcgatct cggggccgac gaagtggtgg ttgatgggga
    15361 ccaggtagaa gccggcctgg ctggcggcga ggtaggcggt gaagaactcg gcgctgttgg
    15421 gcaggacgac ggcgaaggcg tcgccgcgtt ccatcccggc cgcgcgcagg ccgtggacga
    15481 ggcgattggc ggcggcgtgc agtcggccgg cggtccactc ctcgccgtcg ggggcgacta
    15541 ggaccgtgcg gtcggggtcg gccgctgcct gggcccagaa gcccgcgggg ggtgtgctcg
    15601 tcactggccg ctccttccgg cgatgcggtt gatgcgatcg acggcttgct cgaagccgcg
    15661 ggtgaggtcg tcgacgacgg cctggacgct gcgttcgctg ttcatccggc cgacgatctg
    15721 gccgacgggt gtgccgagca gcggctcgac ctcgtacttc tggatccggg agacggcctc
    15781 ggcgacgagc agcccctgca ggggcatggg gagggtgccg ggcccgttcg tgtcgtccca
    15841 ggcgtcggtc cactcggtgc gcagctgacg tgcgggcttt ccggtcaggg cgcgggagcg
    15901 cacggtgtcg ccggagcctg cggccagcaa cttctggatg agcctgggcg agggcagttc
    15961 ggcctctgtg gtggtcagcc atatggagcc gagccacaca ccctgtgcgc cgaggctgag
    16021 tgcggcagcc acctgttggc cactgccgat ccccccggcc gccaggacgg gcagcgggtc
    16081 gaccgcttcc accacctcgg gcgtgagcac catggaggcg atctctccgg tgtggccgcc
    16141 cgcctcgtag ccctgggcca ccacgatgtc gataccgccc tctttgtgct tgacggcgtg
    16201 ccgggcgctg cccgcgagcg cggcgaccag cacaccccgg tcatgggcgc gctccacgac
    16261 gtccgcgggc ggtgagccca gggcgttggc gagcagcttg atcgggtagt cgaaggcgac
    16321 gtcgagctgg ctgcgggcga cctgctccat ccacccggtg atacgccagc cggacgcctc
    16381 cccctcggcc agttcgggca cgccgtactt ggcgagagtg tcgttgacga actgccggtg
    16441 cccctcgggg atcatcgcct cgacatcggc ctcggtcagt gtttgattgt tcggggcctg
    16501 caccttcttg gcgggcatga cgacatccag gccgtagggc cggccgtcga catgggcctc
    16561 gatccagtcg aggtcgcgtt tgaggtcgtc gggggccgtg tagcggaccg cgccgagcac
    16621 tccgaagccg ccggcccggc tgatggccgc ggcgacggcg gggaacggcg tgaagccgaa
    16681 gatggcgtgc tcgactccca gtttcttgct cagctccgtc tgcatgggcg caggatgccg
    16741 cagtcctccg gacgacggaa ggccttttct gatacaccgt cagatctctt tgggccgacc
    16801 gtccaggcct cttgggtcga ccgtccaggc ctcttgggtc gaccgtccag gtctcttggg
    16861 tagaccgccc cgttgacacg acccacacct gacacgaaag tttcaccacg caaggtgatc
    16921 ccggaaagat actttcagcc ggagcggcgg gaggaacctc gatgacggac gacagaagca
    16981 gactgacccg gcgtcaactg gggcgaacag ccctggtcct gggcggcgcc ctggccatca
    17041 cccccttccc cgtcggaccg gcgatagccg cctcctcgtc cggccgcagc accttgcgcc
    17101 acggctcccc cgaacgcgcc gggctcctcc ccgcccacct ccaccgactc gtcaccgacg
    17161 ccgagacgtt cctcgacccc tcccccaagc acccctggta cgcgggcgcc gtcctgctcg
    17221 ccgggcgcgg cggcaccgta gccctgcacc agcccatcgg gatggcgttg cgctaccagg
    17281 cgtacgacga gaagaccgac accggcgtcg agttcccgcc cgaccagcag atccccatgg
    17341 ccgaggacac cgtcttcgat ctggcctcgg tgtccaagct gttcacctcg atcctcgccg
    17401 tgcagcagat cgaacggggt gcgctcgggc tggaggcgac ggtcgcctcc tacctcccgg
    17461 acttcggcag cgctggcaag caggacatca cgatccgcca actcctcacc catacctcgg
    17521 ggttccgcgc ctggatcccg ctgtacaacg cgccgacgta cgaggagaag ctccaactca
    17581 tctggaacga ggcgccgctg aacgcgccgg gcaccaagta cctctactcg gacctgaatc
    17641 tgatctccct ccagctcgtc ctggagaaga tcaccggccg tgagctcgac atcctcctcc
    17701 gcgacgagat caccgccccg ctcggcatgc gctacacccg ctacaaccct cccgccgcct
    17761 ggaagccgaa gatcgcggcc accgaggacg cccggcgccc ctggtccggc ctggaccgtg
    17821 ggctcgtatg gggcgaggtg cacgacgaga acgccttcag cctcggcggg gtcgcgggcc
    17881 acgcgggcgt gttctcgaac gcctgggacc tcgcggtcct cggccggacg ctgctcaacg
    17941 gcggcgccta cggccgctcc cgcatcctgg agccggagtc ggtggagttg atgttcacgg
    18001 acttcaacac cgcattcgcg ggcgacgagc acggcctcgg cttcgagctc taccagcact
    18061 ggtacatggg cgcgatggcc accccgcgca ccgcggggca caccggcttc accggcacct
    18121 cgctggttct cgacccgacg accgactcct tcctcgtcgt actgggcaac tcggtccacc
    18181 ccgtgcgcag ttggcgctcc ggttccgcgc cccgggtcgc cgccgccgac cacatggcgc
    18241 gggccgtacc ggtacgccca cggcacggtc gtaccgcgtg gttctcggga atggcgagtg
    18301 ccacgaccgc gaccctcgcg ctccccgcgc tcgacacgac ctgcggcgac gtacggctgc
    18361 gctgcgctct gtggtgggac accgaacccc agtcggacgc cctcaccctg gagtcgacga
    18421 ccgacggggg caccacctgg cagcagctcc ccttcacgac aacccgccac ggcgagcgac
    18481 cccaggatca cccgaccggc acggtgaacg gctggtcggg ccgcgtctgg caccggctca
    18541 cggcccagct cccggcgcac cggcagctgg tgatccgctg gcggtacacg accgaccgcc
    18601 tgtacgtggg ccgtggcgcg tacgtcgacg gactgcgcgt cgaaacgccg gccaccgtcc
    18661 tcttcgacga agcccgccct gcggacgcgg cgcggatcga ggcgacgggc tgggcagcct
    18721 ccgccgactg aattctcagc ccctcagtca gtgctgtgtc ggtgaaagga gtaggccttg
    18781 ctgactgcct ggaggaggtt ggcaagggcg agagccgtcc atagagcggt aagccctccg
    18841 gttgtggcta ccggagcggc gacggcggcc aggcctccgt agcagatgaa ggtcgacacg
    18901 aaactcggca cggtgcgctt gagaccgatg aggccgaagc cgacgactgc ctgcagcgcg
    18961 tcggtgacga ccacgaccag caccaggggc agaaggtccg tgatctgggg ccgcacatcg
    19021 acgtcctggg tgaacagcgg aacgacccac gaactgaggg cgatcaccgt tgccgcgatg
    19081 gaccccacaa cggccagtgc cagccacgtg cccgcccgaa cgctgcgccg aatgcgcgcg
    19141 ctgtcgtgct tcgttgcgta gtcggagatc agtgggacgg tggcctggcc gaccgccacc
    19201 gcagctgtga agatgaggtt gaccagggag atgccgacgc tgtgaaccgc ggcgctgtcc
    19261 gtccccatcc tggcggccgc gaaggtcaat acgcccagga ccgcgaactt gacgagtacc
    19321 gtgccggcca gcggaatccc cacggtgccc aatgcccaga cctgcttcac atcaggccgg
    19381 cccggataca aagagtggcc gctgagcacg gtagagcggc tgatggccac ctggttgaca
    19441 caggcgctga ccacgctgga ggcgagcatg gcgatgcctg ccccggtcag gccgtaactc
    19501 ggcagcgggc cgggagcacc cacgaggagg acggacagca tggtggatgc ggcggtcccg
    19561 agcagtccgg cccgcatcac cgactttgag tggccgagtg ccaccaggac ggatgttgct
    19621 gacgagctga ccgcgatggc gagtacgctg ccggccagca ggagggggaa cattcccagc
    19681 tggtcgaggg tggtgcgggg aacctcggcc gctcggccga tcagaggaac ggacgcgacc
    19741 gccgccgcag cgatggcgcc gacggtgatc gcgagccacg ttccgctgcg caccacgggc
    19801 aggagacggt cgggatcctc cttgctcggc gtgacgaacg gcatcacacc gcgcagcgcg
    19861 cctgccaccg tggcagtagc ggggctgaag acggccatgg cgacggcgaa ggccgcgagg
    19921 gttgcggtgg cgtggttgcc gagcagtgcg gtgtcgacca gggcgccggc tgaggcggcg
    19981 atcatcgtca ggtacagcgg gagcgctgca gccgctatca cgatccacgt actgcgtccg
    20041 gctggtccag tccccttgct gatcacgggt tcgatcatca cactgcggga gccgacaggt
    20101 cagcgggagg ggcgaactcg gtctgctggg gcgtgtatcg gaagtggatc atggtggtga
    20161 gtgatggccg gccctggtcc ggagctaaga tcactggccc gacgccgacc tcagggctgc
    20221 accgacgtgc gcgagtggca ggcgcgctgt ccggccgtga tgacgatcga catcggcttc
    20281 tggccctgct cgacggccag gtgcagcttg gtggtcaggc cgccgcgcga gcgtccaagg
    20341 ctctggcgca cgcgactacg cgcccgagtc cggttcggac ttcagccgtt ggcggcctcc
    20401 agcaccgcca tcgccgcatt gtgccccggc acgccgctca ccccgccccc acgcaccgcg
    20461 cccgccccgc acagcagcac gttcgcgtgc cgcgtctcca cgccccagcg tccggtgcct
    20521 tcctgggcgt acggccaggc caggtcgcgg tggaagatgt tgccgcctgg caggcgcagg
    20581 tcgcgttcca ggtccagtgg ggtcttggcc tcgatgcagg ggcgtccgtc cgcatccgtg
    20641 gccagacagt cggcgagcgg ctcggcgagg tgggcgtcca gttgggcgag ggtcgacttc
    20701 agcagttcct cgcgtacggc ttcgttgtcg cgctcgaaga gccgggccgg cgtgtgcagg
    20761 ccgaagaggg tgagggtctg gtagccctgt tctacgaggt cgggtccgag gatcgtgggg
    20821 tcggtcagtg agtggcagta gatctcggac ggcggcgcgg cggggagttc gccggcggcg
    20881 gcctgggcgt gggcggtggc cagttggccg tagctctc
//
