LOCUS       NZ_CP025227            23330 bp    DNA     circular CON 14-APR-2024
DEFINITION  Actinomyces wuliandei strain 299 chromosome, complete genome.
ACCESSION   NZ_CP025227
VERSION     NZ_CP025227.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces wuliandei
  ORGANISM  Actinomyces wuliandei
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3107761)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2017) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, No.155 ChangBai Road, Changping District, beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004010955.1-RS_2024_04_14
            Annotation Date                   :: 04/14/2024 19:14:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,606
            CDSs (total)                      :: 2,544
            Genes (coding)                    :: 2,496
            CDSs (with protein)               :: 2,496
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 18 of 48
            Pseudo Genes (incomplete)         :: 37 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 9 of 48
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1794933
            Orig. end                         :: 1818263
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025227.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23330
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="8"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23330
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23330
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13330](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13330)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(297..316)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.47"
                     /tool="antismash"
     gene            complement(1925..2125)
                     /locus_tag="CWS50_RS07415"
     CDS             complement(1925..2125)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS07415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127842271.1"
                     /transl_table=11
                     /translation="MLLSLSRLAGWVLMVLGSMMVPLAAALNQPGLQALAILILLAATA
                     ALSASLKEDATGRWWADGRDR"
     CDS             complement(2264..2392)
                     /gene="allorf_1797197_1797325"
                     /locus_tag="allorf_1797197_1797325"
                     /protein_id="allorf_1797197_1797325"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRPPGRHGELCVSPGGPEVLPGAVRVVSSFWGRSGSCFPSRG"
     CDS_motif       complement(2345..2392)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRPPGRHGELCVSPGG"
                     /locus_tag="allorf_1797197_1797325_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2264..2344)
                     /prepeptide="core"
                     /locus_tag="allorf_1797197_1797325_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-1.30"
                     /molecular_weight="2599.0"
                     /monoisotopic_mass="2597.4"
                     /core_sequence="PEVLPGAVRVVSSFWGRSGSCFPSRG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRPPGRHGELCVSPGG"
                     /leader_location="[2344:2392](-)"
                     /alternative_weights="2617.0"
                     /alternative_weights="2635.0"
                     /alternative_weights="2653.0"
                     /alternative_weights="2671.1"
     CDS             complement(2320..2424)
                     /gene="allorf_1797253_1797357"
                     /locus_tag="allorf_1797253_1797357"
                     /protein_id="allorf_1797253_1797357"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRQAAAGAQSWCAPRGGTVSSASARAVPRSCPVL"
     CDS_motif       complement(2401..2424)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRQAAAGA"
                     /locus_tag="allorf_1797253_1797357_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(2320..2400)
                     /prepeptide="core"
                     /locus_tag="allorf_1797253_1797357_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="2489.9"
                     /monoisotopic_mass="2488.3"
                     /core_sequence="QSWCAPRGGTVSSASARAVPRSCPVL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRQAAAGA"
                     /leader_location="[2400:2424](-)"
                     /alternative_weights="2507.9"
                     /alternative_weights="2525.9"
                     /alternative_weights="2543.9"
                     /alternative_weights="2562.0"
     gene            complement(2458..3366)
                     /gene="dapA"
                     /locus_tag="CWS50_RS07420"
     CDS             complement(2458..3366)
                     /EC_number="4.3.3.7"
                     /GO_function="GO:0008840 - 4-hydroxy-tetrahydrodipicolinate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010613644.1"
                     /locus_tag="CWS50_RS07420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4-hydroxy-tetrahydrodipicolinate synthase"
                     /protein_id="WP_127842272.1"
                     /transl_table=11
                     /translation="MSIAASRTFGSVGVAMVTPFTPGGEVDVDAACALAVSLVDDGVDT
                     VLLSGTTGEAPTTHLPEKQLLIREVKAALGERAMVIAGAGSNDTAHAVRIGVGSQEAGA
                     QGLLVNAPYYNRPSQEGVYRHIMAVVEATDLPVMIYDIPGRTGVRISDQTLARLAEHPR
                     VKAVKDATGDVEQGFERMEATGLEYYSGDDGLNFAWLTHGASGVVSVVAHADAHSWREM
                     IAEVDSGDLAGARAVAQRMRPLVRAMMGGGQGAVMAKEALVLQGRLPHAALRLPLVRAQ
                     AEEVEALRTTLEACGLLAQEV"
     gene            3495..4322
                     /locus_tag="CWS50_RS07425"
     CDS             3495..4322
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009406098.1"
                     /locus_tag="CWS50_RS07425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_127842273.1"
                     /transl_table=11
                     /translation="MTAPSTPDTPEGDGPDDVAPGPVPGPSHADAGARDADTTGATGAN
                     GFVREARPEDLAAIGSVHAASMLASLEAGHRGAHGTGLPEGVRAMISAPVIATGWQEAV
                     TSPPSREHHVLVATQAGSVVGLLGLAPTQSLSTARAASDRDADPGSPEDGASEHPAAGA
                     GALAPTGAGGAQGPLLLNDAQAPEDREPLPAAEVTALGVDPAHQRRGHGSRLLAAAADT
                     ARGHGARALVVWAVRGDESLSWFLRSAGLEPTGAQRQLGVGQGVTEDCWVAGL"
     gene            complement(4479..4784)
                     /locus_tag="CWS50_RS07430"
     CDS             complement(4479..4784)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005986096.1"
                     /locus_tag="CWS50_RS07430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HigA family addiction module antitoxin"
                     /protein_id="WP_243118231.1"
                     /transl_table=11
                     /translation="MTTTDRIAPVHPGEVLMEDFIKELGITQNKVAVAVGVPPRRINEI
                     VLGKRAVTADTAARLARYLGTTAEFWLNLQARYDLDLVEDSHGEALARIRPLGHVA"
     gene            complement(4771..5052)
                     /locus_tag="CWS50_RS07435"
     CDS             complement(4771..5052)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008730511.1"
                     /locus_tag="CWS50_RS07435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type II toxin-antitoxin system RelE/ParE family
                     toxin"
                     /protein_id="WP_127842275.1"
                     /transl_table=11
                     /translation="MIRSFADKATERLWRREHVASLDARVERVALRKLRQLGAAASLED
                     LRAPPGNHLERLRGDRSGQHSIRINAQWRLCFVWTAAGPEEVEIVDYH"
     gene            complement(5194..5946)
                     /gene="dapB"
                     /locus_tag="CWS50_RS07440"
     CDS             complement(5194..5946)
                     /EC_number="1.17.1.8"
                     /GO_function="GO:0008839 - 4-hydroxy-tetrahydrodipicolinate
                     reductase [Evidence IEA]"
                     /GO_process="GO:0009089 - lysine biosynthetic process via
                     diaminopimelate [Evidence IEA]"
                     /codon_start=1
                     /gene="dapB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003786326.1"
                     /locus_tag="CWS50_RS07440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4-hydroxy-tetrahydrodipicolinate reductase"
                     /protein_id="WP_127842276.1"
                     /transl_table=11
                     /translation="MSITVAVIGAAGRMGSTVCQAVEQAEGLELVARLDVGDTLDAEHL
                     GGAQVAVDFTVPSVTETNVHALVDAGCDVVVGTTGWSEEAYKRVREHLARPEAAGRSVL
                     VAPNFALSAVLAMSLAARAARFFESAEVIELHHPDKVDAPSGTALATARGIAAARAAVG
                     LGPVPDATQADPDGARGAVVDGIHVHAVRLRGLTAHEEVVLGNPGEQLTIRTDSFDRAS
                     FMPGVILAVRQVGGLEGLTVGLDALLEV"
     gene            complement(5987..6748)
                     /locus_tag="CWS50_RS07445"
     CDS             complement(5987..6748)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS07445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127842277.1"
                     /transl_table=11
                     /translation="MTEERSVQPVVTWRRVLVSELGKAVRTRSVQVLVVLELCVVAFFS
                     SHVGVPGVQLASLPAGLAGVVVAGAEYSSGAIMSTVVAAGRRSRLFWAQMVGTGVVVGI
                     PALLLMLGLVATTGPYADYRGVPLELAASLETVVRAALVLALVSVAGALVAMGTRSVAT
                     AAMALALVVGVAQVLVILVPAVLTMGRWTIRLPDWVHTVMPNAVIARLQGVASIPPSTW
                     LEEPVPTVLVAAAWCLPLLLWGHHRLTRSDL"
     gene            complement(6745..7644)
                     /locus_tag="CWS50_RS07450"
     CDS             complement(6745..7644)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CWS50_RS07450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_127842278.1"
                     /transl_table=11
                     /translation="MLFLRDVEKRYQGVLGFSCTSFAAPDGMVTCVVGPNGAGKTTALK
                     TIGGLVRADGGEVLVDGAAPGALPDPLRHLGLVLGPDHWVGSRTGLQCLAGLARTCGVP
                     VARVRQCLDEAGIGAVGDRRVGTYSLGMRQRLSLAAAMLGDPHNLVLDEPFNGLDPEGV
                     RWLRSLLRRLAGQGRAVLVSSHLLAEVEDVADRVVALKEGRVLAQVRTDEVRRPGGVLV
                     RVDELSQAVALARSRGWQVATTVREGESKDAVVIDAGIQEVQTAFLDEGVLFTEMREAR
                     RSLEDWFFRVQEEGGQES"
     misc_feature    7608..7626
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.88"
                     /tool="antismash"
     misc_feature    7656..7669
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.09"
                     /tool="antismash"
     gene            complement(7682..9805)
                     /locus_tag="CWS50_RS07455"
     CDS             complement(7682..9805)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="CWS50_RS07455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_243118539.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.6e-27, bitscore:
                     93.2, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFRRVPFVRFQQSETDCGLACVSMLLASFGRGVSMEALREMVSW
                     GRDGTSVAAITELFDKLAVHYVVEQIDDISYFSGSEFRGPCIVYWRFSHWVVVEGASRR
                     GFAVVDPQRGRYMVSVEEYSRSFTGILIRVVDTSSQRFSRLARLGAAIQRSCSAGRLFF
                     RFVDRPRLLLSIAAAFVVQAVPALGAWLTATLFGRVTLGLNYDTFVVCCLSLLAFGLGS
                     GLAMLARGVASAQLGASVRMSVSSQLLSAFLNASFRYVQGRSIGDVVNRIVGVQVVQNL
                     VANVLLMAIFDLGSMLVSVVVLALLWTEVGACVCIVLTLYAFFLFFSGRRLYHLSMASV
                     NAASSAQGQLVGICAAAEAIKLAQAEHRVSSSWAGSLGAEVLSEYMFSRFQSVVQAVGI
                     FVQQVLPLCILAYGLLMFTQGGVSIGLIAGVNSLLGSVLGSAMMISYSAQQILTSGVAL
                     ERVRDLLSAPQESSKAVSGGEVGDATFRRSLTLSNVVKRYGGSSAPVLRDVSLTVKPGD
                     FIGIKGRTGSGKTTLLRTVIGLENIDGGDIKFDGVSKDMLTVKSVRSLFGVVSQDPQIM
                     AGSLRYNLLLGVEDSFSDDLLFQALDVVELSHEVRMMPMELDTVVGDAGVGISGGQRQR
                     LAIARAVLRDCSVMVLDEATSALDVSTEMVVIDRLRRRGMAVICATHRDSTLRSADAVY
                     EISGGRLMRARLR"
     misc_feature    complement(7703..7705)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8018..8020)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8585..8587)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8660..8662)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9221..9223)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9620..9622)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..13330)
                     /gene="lanM"
                     /locus_tag="CWS50_RS07460"
     CDS             complement(10001..13330)
                     /GO_process="GO:0009403 - toxin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0018193 - peptidyl-amino acid modification
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="lanM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CWS50_RS07460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM"
                     /protein_id="WP_164860102.1"
                     /sec_met_domain="DUF4135 (E-value: 1.3e-77, bitscore:
                     258.8, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 8e-41, bitscore:
                     137.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIEAIAKKASFIDEEIVVTPESVSTEKGAVRMKMILEQYPGYEA
                     GDEQLFLQEHGFKSLADMSSRLGIVDYSSQSIVHSNVDGTWVATLLQILALVTETEEND
                     GVGQGSRTDAVEIFLRPFEKYISNQLNSEIKRVAASFENMRLGDEFVKQFCAAPRDELK
                     MLVTQTLILEVHVAKHEHEHAGSRYTLADYTSTMGRSSFYEELFEEYATLGRRLVTRVL
                     TTVRSRRELLNRLLSDEQQLLKDYLQGLSVMTGVSFSKGDKHNGGRSVTVIYFEGGKGL
                     VYKPRSMQAEALFFGYIERLSSRLGLSLMVPSCFCKEGYGWQEYIEHLPADGHFAFSQF
                     YEELGVLLAAAYAFGLTDLHHENIVASGAHPVLIDAETLFAPQVDKVVRPGLSLNLESS
                     DEARTFTCLHTGILPTDQNDDAAHIWGAAYSEGRRSPFEVPIIPSVDSLDSEVKYDYVE
                     MGAEANAPYYGSEAGDWTSYETEVIRGFELAYRHIKENKAELVGPRGLIDEFNGAPVRI
                     VLKATMAYSIMLMTSNHPDYMREGTEVERLFSYVWRFPSLADPRIWFSELKQMRRLDVP
                     FFSVPFAETKIVDTDGTEVADIRQDLRSWWSTHVNAFDDDDLERQLWFIRASYVTSVAG
                     EDYELDHPNRIHPLLLRGSVNTGSQLELSVKECASEAAREVTRRLCRKALLGNKGGWYS
                     ITVVGNEKWSVQPVAMDLYNGDSGIGYALMYLGLAFADRDAEETSVALARQVSMFLTHV
                     ARSVSENTSDSQNPPYNDIGLYGAIGGGIYFLSHVVAVLGDEDGYLKESLAAITKALMM
                     RRPDERYLDVVSGSAGLIEALRSLSAAVPEVREATAKLAEMHARNLCSTAEWGKSGSCS
                     WQQDHMGRNALVGYSHGASGVVNALADASVLCDTDEFRSFIDGGLVFEKEWRDTLGFWP
                     DLRDETSSSPGVPGMISWCHGAPGVALARLQLLEKGFSPDIFSESGIVEDMLDAIEETV
                     SRSLLKEGSHYMNSMALCHGRLGSLEILSRIERFRMRSSELFSDCTAVSLLQEADTYWR
                     SVIVQAYEDGLVCGVPRGLEVPGVMTGLSGIGLSLMRYGGDRWNFPLLICADIPRVDLA
                     FD"
     misc_feature    complement(10211..10213)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10214..10216)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12416..12418)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12605..12607)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12680..12682)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12761..12763)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13750..13765
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.14"
                     /tool="antismash"
     misc_feature    complement(13752..13765)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.13"
                     /tool="antismash"
     misc_feature    13752..13766
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.6"
                     /tool="antismash"
     misc_feature    13753..13766
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.07"
                     /tool="antismash"
     misc_feature    complement(13753..13768)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.79"
                     /tool="antismash"
     CDS             14034..14213
                     /gene="allorf_1808967_1809146"
                     /locus_tag="allorf_1808967_1809146"
                     /protein_id="allorf_1808967_1809146"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRFVWLSLGFLVFRGSSCVTYYSTPLTLEMRMCQTMLCRYSLRQL
                     QQQGVLWHCSQAPP"
     CDS_motif       14034..14141
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MRFVWLSLGFLVFRGSSCVTYYSTPLTLEMRMCQTM"
                     /locus_tag="allorf_1808967_1809146_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       14142..14213
                     /prepeptide="core"
                     /locus_tag="allorf_1808967_1809146_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="2630.1"
                     /monoisotopic_mass="2628.4"
                     /core_sequence="LCRYSLRQLQQQGVLWHCSQAPP"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRFVWLSLGFLVFRGSSCVTYYSTPLTLEMRMCQTM"
                     /leader_location="[14033:14141](+)"
     misc_feature    14715..14728
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 17.37"
                     /tool="antismash"
     gene            complement(14861..15391)
                     /locus_tag="CWS50_RS07465"
     CDS             complement(14861..15391)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="CWS50_RS07465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavoprotein"
                     /protein_id="WP_127842281.1"
                     /sec_met_domain="Flavoprotein (E-value: 6.7e-18, bitscore:
                     62.1, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTVITGAVGAALMPAWMLQLRNDHDISIKCVLTPSAEHFLSTNA
                     MSAITGQQTYLESSWQVSGKATHKELAYWADKVLVAPASLNSMVKIKQLSSSNLALAAI
                     AFTVAPVYIVPAVSGPIVKKRRYKELLESLESDHTLILPSTEGSSVSLVNFSKEEGGMA
                     TYEDVRAQMLSGY"
     misc_feature    complement(14873..14875)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15558..16019)
                     /locus_tag="CWS50_RS07470"
     CDS             complement(15558..16019)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS07470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127842282.1"
                     /transl_table=11
                     /translation="MSSDLQAQASCKTQPIPSRLMVVRLLFLAGALLCCAHAASIYLSM
                     QRLPNGSETTAGPVVAMLALMLEHAAWWYWLRNISETKIKWAKRMSYMHVVMFVSATLN
                     NSPQRSSNLLLGAPTISDGIVAEAAPPLLVAVSVVAAILLKIYFNQRRH"
     misc_feature    complement(15624..15626)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15681..15683)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15876..15878)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16281..17150)
                     /locus_tag="CWS50_RS07475"
     CDS             complement(16281..17150)
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013070.4"
                     /locus_tag="CWS50_RS07475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PRD domain-containing protein"
                     /protein_id="WP_127842283.1"
                     /transl_table=11
                     /translation="MSAGSRAAHWQIVRVLNNNAVLARDRDAGQAVLLGRGIGYGRHLG
                     DPVDAGSVSEVFVPDADHSVPRLVSFLSETPLETVRLASEALEPVRAQGRVGVSQALVL
                     AVADHLRFAVERSRAGISVEHPLRWEVQQLYPEETRWGRQTVVLVGERLGVRLEDGEAT
                     TLALHLVNAQFAGSDLAPTVRMTRTITQILGVVSAVLGIQVDEQAMSTARFATHLRYLF
                     VRLEDGRQISDSLEDLVTPIRRAQPLAFRAATRVRALLELNGPRLTDAELAYLTLHIAR
                     LASECQPR"
     gene            complement(17187..19208)
                     /locus_tag="CWS50_RS07480"
     CDS             complement(17187..19208)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0015573 - beta-glucoside transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0009401 - phosphoenolpyruvate-dependent
                     sugar phosphotransferase system [Evidence IEA]"
                     /GO_process="GO:0015759 - beta-glucoside transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1145: Glucose-specific phosphotransferase enzyme IIA"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR01995.1"
                     /locus_tag="CWS50_RS07480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="beta-glucoside-specific PTS transporter subunit
                     IIABC"
                     /protein_id="WP_127842284.1"
                     /transl_table=11
                     /translation="MAEKVRDYPRLARDIIKVVGGGDNIRQASRCATRLRLVLASTPEG
                     AKDKVSQMAGVITVVESGGQFQVVIGNHVTEVYDAVAEELDLANRADAEAEVPRQSVLN
                     RVIATMSGVFAPFIYVLAAAGILQGALIITRMVHPAFTGTGTDQVLSFMSWTPFTFLPV
                     LIAITASRHFQTNMFIAVLCCAAIMNPDWTTLADSISEGETVSFLTIPMSPTVYTSSVL
                     PPLILVWLLSYLERFLNKYLPAAARQLFTPFFCLVIMVPLTFLVIGPLSSAGATGIANG
                     YNWLVERAPVVAGAIIGGVWQVAVIFGVHWGVTPMVLANYDLYGQDTFQAFQTAAVIGQ
                     VGAAVGVLTRTRSRQMRGVAGSAAVTGIFGITEPAIYGVTLRLKRPFVMGCAAGAAGAV
                     VVALFGSRSYAYAGLPGPLTILNSYSETVPSSLVGEVIGCLVAFLGAIVLVWVTGFEDP
                     QDSDKDSDNAGDVSGAGRDVGTAEGNGASAEPGTMVSQLGEESYDEQLAAASQRYVVSS
                     PVSGDLVPLRDVPDAVFASGAMGKGVAVEPGEDGIYAPFDGRVVMVAATRHALGLISED
                     GVELLIHIGIDTVELDGQHFTSHVEAGQEVRAGDLLMELDREAIAKAGYRTLTPVVVTN
                     ADAYDKVLLYPQSSVRHGEELATALRGAREPAGSGDLT"
     CDS             complement(19481..19564)
                     /gene="allorf_1814414_1814497"
                     /locus_tag="allorf_1814414_1814497"
                     /protein_id="allorf_1814414_1814497"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MSRAEVPAMARGVVVPCPGVVAGSRRT"
     CDS_motif       complement(19538..19564)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSRAEVPAM"
                     /locus_tag="allorf_1814414_1814497_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19481..19537)
                     /prepeptide="core"
                     /locus_tag="allorf_1814414_1814497_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.90"
                     /molecular_weight="1699.1"
                     /monoisotopic_mass="1698.0"
                     /core_sequence="ARGVVVPCPGVVAGSRRT"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSRAEVPAM"
                     /leader_location="[19537:19564](-)"
                     /alternative_weights="1717.1"
     gene            complement(19620..21101)
                     /locus_tag="CWS50_RS07485"
     CDS             complement(19620..21101)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009232130.1"
                     /locus_tag="CWS50_RS07485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pitrilysin family protein"
                     /protein_id="WP_243118232.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 2.4e-33, bitscore:
                     112.5, seeds: 24, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M16_C (E-value: 8.3e-36,
                     bitscore: 121.0, seeds: 139, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMTSAAGSAARSATARATDGRADSASGGTVPSTGSSPGAGPGTPV
                     VGAQRSEGYTEAELVRGVPGQAGTELSLEDDGALTRRSVLPGGVRVITEAVPGLRSTAI
                     GLWLGVGSRDEASGQEGSTHFLEHLLFKGTTTRSASEIAEAFDMIGGEANAATSKEHTS
                     YYARVLAPDAMDALDVVTDMVTSSLLDPDEVETERGVIVSELAEAADDPAEVAQEAFAR
                     AAFGDGTPLGRPIGGSYETVSEVPREAVWDHYRRTYASDALVVAAAGAVDHDELCERVS
                     QDLARAGWDSSPVAPRPRRFETEPVTPLEVHDVRVGRDTEQAHLYLACQGIPVRDERRW
                     AMSVLTTVLGGGMSSRLFQEVRERRGLAYTTYAFDISYAGAGAFGLYAGCAPRKVEEVG
                     AVMLGEFEKLAAHGPTQREMARARGQLRGAMVLGGEDSLARMSRLGRSEVVTGRLRSMG
                     ESLRLLDQVTAQEVRDLAAWLVAQQRCQVLVGPGD"
     gene            complement(21449..22993)
                     /locus_tag="CWS50_RS07490"
     CDS             complement(21449..22993)
                     /EC_number="1.11.1.6"
                     /GO_function="GO:0004096 - catalase activity [Evidence
                     IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076632.1"
                     /locus_tag="CWS50_RS07490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="catalase"
                     /protein_id="WP_257494609.1"
                     /transl_table=11
                     /translation="MEKPINLSSGSGSTTANGAPATSERHSITLGPDGPLLLHDHHLVS
                     SLAHFNRENIPDRKPHAKGSGAFGELVITHDISRYTKAAALQPGTHTRALLRFSTVAGE
                     AGSPDTWRDVRGFALKLYTTEGNWDLVGNNTPVFFLRDPMKFPHFIRSQKRLGDKGLRD
                     QTMQWDFWTLSPESAHQVAYLMGDRGLPRTWRHMNGYGSHTYMLINEAGERFWTKFHFH
                     TNQGVENWAGQDAEELAGIDSDFHRRDLFEAIERGDYPSWTLSIQVMPYEEAKTYRINP
                     FDLTKTWPHADYPLITVGTLTLNENPANFFAQIDQAAFAPSNIVPGIGFSPDRMLLARV
                     FAYADAHRARLGVNHDQLPVNQPLPEVRERANTYTFDGPMRYFHSGGQPTYAANSGGRP
                     YADEQGRLEDGWEADGEMVVAAQTLREDDDDFSQAGTLVRDVFTEAQRQRLVETVSDSL
                     VQVERPEVLERALWYWDSIDAAVGQRIRDAVARLTSQAGAVSVERTPLREGDSEEE"
ORIGIN
        1 agcgtgccgg ggactcgggc ctgtaccacc ggccccacta ccagccaggc atccctgcga
       61 tcatcaaggt acctgactcc ggcgtgagca gcctgctgga gacggctgca aacttctacc
      121 cccagcgggt cgccctggac ttcatgggtg ccaccctcac ctacgccgag ctccttgagg
      181 cctccgaacg tgccgcctgg ctgctgcacc atgccggcgt gcgccacggc gaccgtgtgg
      241 ccctgctgct gccaaactgt ccccagcacg tcgtcgccat ctacgcggcc ctgcggctgg
      301 gggcgatcgt ctccgagcac aaccccctgg ccccggccgc ggaggtccgc tcccagctgg
      361 ccagcaacgg cgcgcgggtg ctggtggcct gggagaaggg tgtggagcgc ctcctgggcc
      421 gccagagctc tcctggtgct gatcctgtgc ctggtcacgc gcccggccgc gtgcctggcc
      481 gcacggactc cctgccgacg gacctgacag tcttcagcgt ggacctgtcg gcagccatgc
      541 cccgtcgggt gcgggcggcc ctgcacctgc ccgtgccccg cgcccgccag gcacgcgcct
      601 ccatgagggc tgaccacctc ccgacgcgag tccggtcctg ggaccgtgag gtggcccgtt
      661 gccagcgcct gcccgccacc cacccctacc ctgcggtcca cgacgtcgcg gtcctgctct
      721 acaccggtgg caccacgggc acacccaagg cggcgatgct gacccacgcc aacctgcggg
      781 ccaacgtgaa ccaggcgatc gcctgggtgc cgatgctgca cgagggggcg gagaccttcc
      841 tggcgctcct gccattcttc cacgccttcg ggctgacctt caacgtgctc agcgccgtgc
      901 acaaggcggc gacccaggtg ctgctccccc ggttcgacgt ggaccaggtg ctggccgccc
      961 acaggcgtcg gcccttcacg ttcttcgtcg gggtgccggt catgttctcc cgcatcctgg
     1021 agggcgccca ggcccgcggg gtgtccctgc ggaccctgcg ctacggcgtg tgcggtgcgg
     1081 cacctatgcc gcgtgaggtc ggccagcgct gggaggaggc gaccgggggc tacttcgtgg
     1141 agggctacgg gatgaccgag accagcccca tcgtctcggg cacgccgatg ggaccgggac
     1201 gtcggctggg ctctctgggg ctgcccttcg cctccaccga cgtgcgtgtg gtggaccccg
     1261 acgacccctc ccgggaggtg cccgacggcg agccaggcga gctcctggtg cgcggccccc
     1321 aggtcttcgc cgggtactgg gaggaccccg aggccaccgc agccgccctg ctggagggcg
     1381 ggtggctgcg caccggtgac atggtgcgtc gggaggactc cttcctgtgg atggccgacc
     1441 gcaggcgcga gctcatcctc accgggggct tcaacgtcta cccctcccag gtggaggcgg
     1501 cggtgcgctc cctggaagcc gtggccgacg tggccgtggt gggcctgccg gacggggccg
     1561 gcggggaggt ggtggcggcc gtggtggtcc tggagccggg caggcaggtg acgctggcgg
     1621 aggtgcgcgc ccacgcggag gcgaccctgc cccgctacgc cctgcctcgc tgcctcgagg
     1681 tggtcgagga gctaccgcgc tcaatgatcg gcaaggtgct gcgccgggag gtcaggctca
     1741 ggctgctgga gggcggctca tgacaggtgg tgaccacggc tgccgctagc ccaccacatg
     1801 gcggccaggc agggcgggac gggacgcggc aggcgcgcca cccggcgtca cctagcgtct
     1861 cggcgcctgt gccgcctacc tcccacgccg ggacggtcgc caacggcccc gccccgtcta
     1921 ctcgtcacct gtcccgcccg tctgcccacc acctgccggt ggcgtcctcc ttgagcgagg
     1981 cgctcagggc ggccgtggcg gcaagcagga tgaggatggc cagggcctgc agccccggct
     2041 ggttgagcgc ggcggccaga gggaccatca tggaccccag gaccatgagg acccacccgg
     2101 cgaggcggct aagagacaga agcacggtac ggtcctttcc tgatcaggcc ccggccgggc
     2161 acccccgggg ccgggggacc tgcaagggcc acaagagaca cggacggccg acgagctgcc
     2221 gacctgacag gtcctattcc acaggaggcg ccgcgaccgc gaatcacccc cgggaaggaa
     2281 aacacgaacc agatctcccc cagaaggagg agaccaccct cacagcaccg ggcaggacct
     2341 cgggaccgcc cgggctgacg cagagctcac cgtgccgccc cggggggcgc accaggactg
     2401 ggcgccagca gcggcctgcc gcaaccggac cagcgcaggt cctgcggcag gtggcagtca
     2461 gacttcctgc gccagcagcc cacaggcctc cagggtggtg cgcagcgcct cgacctcttc
     2521 cgcctgcgcg cgtaccaggg gcaggcgcag ggcggcgtgg ggcaggcgcc cctggagcac
     2581 cagggcctcc ttggccatga ccgccccctg gccacccccc atcatggccc gcaccagggg
     2641 cctcatgcgc tgggcgacgg cccgggcacc tgccaggtcc ccggagtcga cctcggcgat
     2701 catctctcgc caggagtggg cgtcggcgtg agccaccacg gatacgacgc cggaggcacc
     2761 atgggtcagc caggcgaagt tgaggccgtc gtcgccggag tagtactcca gccctgtggc
     2821 ctccatgcgc tcaaagccct gctcgacgtc accggtggcg tccttgaccg ccttgacgcg
     2881 ggggtgctcg gccaggcggg ccagggtctg gtcactgatc cgtaccccgg tgcggccggg
     2941 gatgtcgtag atcatgaccg gcaggtcggt ggcctctacc acggccatga tgtggcggta
     3001 gacgccctcc tgactgggac ggttgtagta gggggcgttg accaggagcc cctgcgcccc
     3061 cgcctcctgg gagcctacgc cgatacgtac cgcgtgggcg gtgtcgttgg agcctgcccc
     3121 ggcgatgacc atggcgcgct cccccagggc cgccttgacc tccctgatga gcagctgctt
     3181 ctccggaagg tgggtggtgg gggcctcccc ggtggtgccc gacagcagga ccgtgtccac
     3241 accgtcgtcc acgaggctga cggccagggc acaggcggcg tccacgtcca cctcgccacc
     3301 aggggtgaag ggcgtgacca tggcgacacc gacggagccg aaggtgcggg aggcagcgat
     3361 gctcatggga caagcctacc ggtagcgctc agcacagcct atcgctttgg tcatgtgttc
     3421 ttcgccagcc cgtcggtccc ctccccggac cgcccggatg gctgggtggc gcccgggcag
     3481 gataggctcc gggcatgacg gctcctagca cgcctgacac gcctgagggc gacggccctg
     3541 acgacgtcgc accgggccca gtgccaggcc cgtcgcacgc ggacgccggt gcccgggacg
     3601 cggacaccac aggcgccaca ggtgccaacg ggttcgtgcg agaggcccgc cccgaggacc
     3661 ttgccgccat cggctccgtc cacgccgcct ccatgctggc ctccctggag gccggtcacc
     3721 gcggcgccca cggcacgggc ctgcctgaag gggtgcgcgc catgatctcc gcccctgtca
     3781 tcgccaccgg ctggcaggaa gccgtgacct cgcccccctc ccgggagcac cacgtgctcg
     3841 ttgcgacgca ggcagggtca gtggtcggcc tgctggggct cgcgccaacc cagtcactca
     3901 gtacggccag ggcagccagt gaccgggacg cggaccccgg cagccccgag gacggcgcga
     3961 gtgagcaccc cgctgctggc gcaggcgccc tggcacccac gggagctggc ggagcgcagg
     4021 gtcctctgct cctcaatgac gctcaggcgc ccgaggaccg ggagcccctg cccgcggccg
     4081 aggtgacggc cctgggcgtg gacccggccc accagcgacg cggccacggc tcccgcctgc
     4141 tggccgccgc cgccgacacc gcccggggcc acggagcccg ggcgctcgtg gtatgggcgg
     4201 tgcgggggga cgagtcgctg tcctggttcc tgcgctcagc cggtctggag cccaccgggg
     4261 cacagcgcca gctcggcgtg ggtcagggag tcaccgagga ctgctgggtg gccgggctgt
     4321 aggggcgcac tgagcaggcc taccagcccc gcgtcaggcc gccgtgtcct cccggctctt
     4381 cgcagatcta ccgactcctc gccacatacc accgtacgcg tagcttccga ggagtcggta
     4441 ggtctcgaca gctggccccg caaatccagc accttccctc aggcgacgtg gcccagcggc
     4501 ctgatccgcg ccagcgcctc accgtgggag tcctctacca gatcgaggtc gtacctggcc
     4561 tggaggttca gccagaactc cgccgtcgtg cccaggtatc gggccagccg ggctgccgtg
     4621 tcggcggtca ccgctcgctt gcccagcacg atctcgttga tgcggcgcgg cgggaccccg
     4681 accgccaccg cgaccttgtt ctgggtgatc cccaactcct tgatgaagtc ctccatgagt
     4741 acctctcccg gatggaccgg ggcgatgcgg tcagtggtag tcaacgatct caacctcctc
     4801 agggccagca gcagtccaca cgaagcagag ccgccactgg gcgtttatcc tgatactgtg
     4861 ctgaccagac cggtcgcccc tcagacgctc gaggtggttt cccggtggcg cccgtaggtc
     4921 ttcaagagac gcggcagcac cgagctggcg aagcttgcgc agggcaaccc gttcgacgcg
     4981 cgcgtcaagt gaggcaacgt gctcgcgacg ccacagcctt tctgttgcct tgtccgcgaa
     5041 cgacctgatc acggcccaag catataacgg accgcgtcat taacgcaaga cggtaaacgg
     5101 attcctcgga acagccgagg tgcagccagc gcgtcgggac acctgccacc ggtcctgagg
     5161 ctggtcacgt cttttgatca cggggatctc ccgctacacc tccagcaggg cgtccagccc
     5221 caccgtcagg ccctccagcc cgcccacctg gcgcaccgcc aggatgacac cgggcatgaa
     5281 ggaggcgcgg tcaaaggagt cggtacggat ggtcagctgc tcccccgggt tgcccaggac
     5341 cacctcctcg tgcgccgtca gcccgcgcag gcgcacggcg tggacgtgga taccgtccac
     5401 caccgcgccc cgggcaccgt ctgggtcggc ctgggtggcg tcaggcaccg gacccagacc
     5461 gaccgccgcc cgggcggcgg cgatcccacg ggcggtggcc agggcggtgc cagagggggc
     5521 gtccaccttg tccgggtggt ggagctcgat gacctctgcg gactcgaaga agcgtgcggc
     5581 cctggcagcc aggctcatgg ccagcacggc ggacagggcg aagttcgggg cgacgagcac
     5641 gctgcgcccg gcggcctcgg ggcgggccag gtgctcacgc acgcgcttat aggcctcctc
     5701 gctccagccg gtggtaccca cgacgacgtc gcagcccgcg tcaacaagcg cgtggacgtt
     5761 ggtctcggtc accgacggca cggtgaagtc cacggcgacc tgcgcgccac ccaggtgctc
     5821 ggcgtcgagg gtgtccccca cgtccagacg ggccaccagc tccagcccct cagcctgctc
     5881 caccgcctgg cacacggtgg agcccatgcg cccggcggca ccgatgacag cgacggtgat
     5941 actcatgacc cgaccctagc agccgtagcc acaggcggcg cacggtctag agatcgctcc
     6001 tggtcagtct gtggtggccc cacaggagca ggggcaggca ccaggctgca gcgaccagca
     6061 ccgtgggcac cggctcctcc agccaggtgg aggggggtat gctggccacg ccttgcagcc
     6121 tggcgatgac ggcgttgggc atgaccgtgt gcacccagtc aggaagccgg atggtccacc
     6181 tgcccattgt cagcaccgct ggcaccagta tgaccagcac ctgggccacc cccaccacca
     6241 gcgccagggc catggcggca gtcgcgaccg agcgcgttcc catcgccacc agagcgccgg
     6301 ccacgctgac aagggccagc accagcgccg cacggaccac ggtctccagg gaggcagcca
     6361 gctcgagggg gacgccccgg tagtccgcgt agggaccggt cgtcgcgaca agccccagca
     6421 tgagcagcag cgctgggata cccacgacca ccccggtacc gaccatctgt gcccagaaca
     6481 gcctggaacg cctgcctgct gccaccaccg tggacatgat ggcgccggag gagtactcag
     6541 caccagcgac gacgacgccc gcgagcccgg cgggcagcga cgcgagctga accccgggga
     6601 cccccacgtg ggaggagaag aaggcgacaa cacagagctc gaggacgacg agaacctgga
     6661 cagaacgggt ccttaccgcc ttgccgagct cgctgaccag cacccggcgc caggtcacca
     6721 ctggctggac ggatcgctcc tcagtcatga ctcctggcct ccttcctcct gcacgcggaa
     6781 gaaccagtcc tccagggacc gcctcgcctc acgcatctcc gtgaagagga cgccctcgtc
     6841 caggaaggcc gtctgcacct cctggatacc cgcgtctatg actacagcgt ccttgctctc
     6901 accctcgcgc accgtggtcg ccacctgcca gccccgcgag cgtgccaggg caaccgcctg
     6961 gctgagctcg tcaacgcgca cgaggacccc accagggcgc cgcacctcgt cggtgcgaac
     7021 ctgggcgagc accctgccct ccttgagggc gacgacgcgg tcagcaacgt cctcgacctc
     7081 cgcgagcagg tgggaggaga ccagcacggc cctgccctga ccggccagcc tgcgtagaag
     7141 agatcgcagc cagcgcaccc cctcggggtc aagaccgttg aagggctcgt ccagcacgag
     7201 gttgtgcgga tcgcccagca tggccgctgc cagcgacagg cgctggcgca tccccaggga
     7261 gtaggtaccg accctgcggt ccccgaccgc gccgataccg gcctcatcca ggcactgccg
     7321 cacacgggcc accgggacgc cgcaggtacg cgccagaccc gcgaggcact ggagccctgt
     7381 gcgggagccc acccagtggt ccggtcccag taccagtccc aggtgccgca gcgggtccgg
     7441 cagcgcccct ggtgcagcac cgtccaccag gacctctccc ccgtccgcac gtaccagtcc
     7501 accgatcgtc tttagggcag tggtcttgcc ggcaccgtta ggaccgacca cacaggtcac
     7561 catgccgtca ggtgccgcaa aggaggtaca agagaatcca agcacacctt gataacgctt
     7621 ctctacatcc ctcaaaaaaa gcattgtaac ctcatgccac ccttcgtaaa ctagcgaaca
     7681 atcaacgcag ccgagccctc attaacctac cacccgaaat ttcataaaca gcatcagctg
     7741 acctcaatgt ggaatcacga tgggtagcac agataaccgc cattcccctt cttctcagcc
     7801 tgtcaataac caccatttcc gtagacacat ccaaagcgct agtggcctca tcaagaacca
     7861 tcaccgagca gtctctaagt accgcgcgcg caatagccag cctctgacgc tggccgcccg
     7921 agatgcctac accggcgtca cccaccactg tgtccagttc catgggcatc atcctaactt
     7981 catgagaaag ttcgacaacg tccagggcct gaaaaagtaa atcatcagaa aacgaatcct
     8041 caacgccgag caacaaatta tacctaagcg atcccgccat gatctgaggg tcctgggaga
     8101 caaccccgaa aagactccgg acggacttaa cagtcagcat gtccttgcta acaccatcga
     8161 atttgatatc tccaccgtca atgttttcca agccaataac agtacgcaga agcgtagtct
     8221 taccggagcc agtcctaccc ttgatcccta taaaatcgcc aggctttact gtcaaggaaa
     8281 catctctcaa cacaggggca gaagaacctc cgtaacgctt gaccacgtta gacaaagtca
     8341 ggctacgccg aaaagtggca tcaccaactt caccacctga cactgccttc gaactttcct
     8401 gcggagcaga aagaagatcc ctaacacgct ccaaagcgac gcctgatgtc aggatctgct
     8461 gagcggaata tgatatcatc atcgcagagc ctagcaccga accaagaagg gagttaactc
     8521 ccgcaatcaa accaatagag acaccgccct gagtaaacat aagcaaacca taagcaagaa
     8581 tacataaagg caatacttgc tgcacaaaaa taccaacagc ttgaaccacc gactggaaac
     8641 gcgaaaacat atactcgctt aaaacctcag cgccaagtga accggcccaa ctagatgaaa
     8701 cacgatgttc agcctgagcg agcttaatag cctcagccgc tgcacatatt ccaaccaact
     8761 ggccttgagc ggaactcgcc gcattaacgc tagccataga cagatgatac aaccgccgac
     8821 cagagaaaaa gaggaaaaat gcgtagagcg tgagaacaat acacacgcat gcaccgacct
     8881 ctgtccacaa caaggccaat accacaacgg aaaccaacat ggaacccaag tcgaaaatcg
     8941 ccatcagcaa aacgttggcc accaagttct gcacaacctg cactccgaca attctattaa
     9001 cgacgtcccc gatagaccga ccttgcacat aacgaaaaga agcgttaaga aacgcagaaa
     9061 gcaactggga actcacagac atacgtacgc tggcacccag ttgcgcagaa gctacgccac
     9121 gcgcaagcat cgccaagccc gagccaaggc caaatgcaag caaagacaaa cagcatacta
     9181 caaaggtatc atagttgagg ccaagcgtta cgcgaccgaa taacgttgcc gtcaaccaag
     9241 caccgagtgc cggaacagct tgaacgacga atgccgcagc gatcgaaagc aaaagccttg
     9301 gccgatcaac aaaccgaaaa aacagccgtc cagcagaaca actccgctgg atcgcagcgc
     9361 ccagccgagc tagacgactg aatcgttgag aagaagtgtc cacaactcta atcaagatgc
     9421 ccgtaaacga cctagaatac tcctcaactg aaaccatata acgtccccgc tgaggatcaa
     9481 cgactgcaaa tcctcgtcga ctagcacctt caacaacaac ccaatgagaa aaacgccaat
     9541 atacgatgca aggaccccga aattcgctgc cactaaaata actgatgtca tctatttgct
     9601 cgaccacgta gtgaactgct aacttatcga acaattccgt tatagcagca acggaagtac
     9661 cgtcccttcc ccaactaacc atttcccgca acgcctccat cgaaacacct cgtccgaagg
     9721 acgcgagcaa catactgaca catgcaagac cacagtcagt ttcagactgc tgaaaacgta
     9781 caaatggaac gcgccgaaaa gacatcaaca ccacccgaaa attatagaac gacgaagaga
     9841 acccaggcag cccccgaggc gaccaagacg accagcgacg ctaccagcat cagcaatgga
     9901 aatacgataa taggccgata cacctctcga ggaagcccac gatatcgttc cttatgtgcc
     9961 ctcattgcgt cctctcgaaa caaccgtcgc ccacctctca tcagtcaaat gccaaatcaa
    10021 ctctaggaat atcagcacag ataagaagtg ggaagttcca gcgatcgccg ccgtaacgca
    10081 taagcgacaa accaattccc gaaagacccg tcatcacacc cggaacttcc agtccccttg
    10141 gtacgccaca gaccaggccg tcttcatatg cctgaacaat tacagaccgc caataagtat
    10201 cagcctcctg taataaactg acagcagtgc agtccgaaaa caactcacta ctcctcatcc
    10261 taaaacgttc aattcgacta agtatctcca atgagccaag tcgtccgtga cacaaagcca
    10321 tcgagttcat gtaatgactc ccctccttca gcaaactacg agaaacagtc tcctcaatgg
    10381 cgtccagcat gtcttctaca atgcccgact cggaaaatat gtctggagaa aaccccttct
    10441 ccaacaactg gagccttgcc agagcgactc ccggtgctcc atgacaccat gatatcatac
    10501 ctggtacccc aggagaagaa gatgtctcgt cccttagatc gggccagaat cccagagtat
    10561 cacgccattc tttctcaaac acaagtcctc cgtctatgaa actacgaaac tcgtccgtgt
    10621 cgcatagtac ggaggcatcc gcaagggcat tgacgacacc agaagcacca tgagagtacc
    10681 ccactagcgc attcctgccc atatgatctt gctgccacga acaagatccc gacttccccc
    10741 attctgcagt tgaacaaaga ttacgggcat gcatctcagc caacttagca gtcgcctctc
    10801 taacctcagg caccgcagcc gaaagactcc gcaatgcctc aatgaggccc gctgaaccag
    10861 acaccacatc aaggtatcgt tcatcaggac gccgcatcat caacgccttg gtaatggcag
    10921 caagagactc cttcaggtat ccatcttcgt ctccaagtac cgcaactacg tgagacaaaa
    10981 agtatattcc tccacctata gcaccataca agcctatgtc gttataaggc ggattctggg
    11041 aatcggatgt gttctcagat acagacctgg ccacatgtgt aaggaacatg gagacctggc
    11101 gggccaaagc aacactcgtc tcctccgcat ccctgtcagc aaaggcaagg cccaaataca
    11161 tgagcgcgta accaattcca gaatctccat tataaagatc cattgccaca ggctgtacgg
    11221 accatttctc attccctact actgttatag agtaccagcc acctttgttc cccaacaatg
    11281 ctttccggca aagccttcta gtaacctctc gagccgcttc ggaggcacac tccttaacac
    11341 tcaactccaa ctgcgaacct gtgttaacag acccgcggag aaggagggga tgaatacggt
    11401 tagggtgatc gagctcataa tcctcaccag caacagacgt cacatatgag gcgcggataa
    11461 accacagttg tctctcgaga tcgtcatcgt caaatgcatt gacatgggtt gaccaccagg
    11521 aacgcaggtc ctgtcgaata tcagcgacct cagtgccatc agtatcgaca atcttcgttt
    11581 ccgcgaacgg aacagaaaag aaaggaacgt ccagtcttct catctgtttc agttcgctga
    11641 accatatacg aggatctgcc agcgagggaa agcgccagac ataactgaat agacgctcaa
    11701 cctctgttcc ttccctcatg tagtcgggat ggttagaggt catgagcata atggaatagg
    11761 ccatagttgc cttaagaact atacgcactg gcgctccatt gaactcatca attagtccgc
    11821 gtggccccac cagctctgcc ttgttttcct tgatatggcg gtaagccaac tcaaatcctc
    11881 taattacctc cgtttcgtaa ctcgtccagt caccggcctc agatccatag tatggagcat
    11941 tagcttctgc gcccatttca acatagtcgt acttgacctc agagtcaagg ctgtctactg
    12001 agggaataat tggaacctcg aacggacttc ttctgccttc ggagtaagca gcgccccaga
    12061 tatgtgcagc atcgtcattc tggtcagtcg gcagtattcc ggtatgaaga caggtgaaag
    12121 tgcgagcctc gtctgagctc tccagattaa gagacagtcc tggcctcacc accttatcca
    12181 cttgaggagc gaacagagtc tccgcgtcga ttagcaccgg atgagctcca cttgccacta
    12241 tattctcgtg atgtagatcg gtaagcccaa acgcatatgc tgccgcaagg agcactccta
    12301 gttcttcata gaactgagag aaagcaaaat gcccatcagc cggtaggtgt tcgatatact
    12361 cctgccaccc atatccctcc ttacagaagc aactaggtac cataagcgac agtcctaagc
    12421 gagaagacag ccgttcaatg taaccaaaga acagcgcctc ggcttgcatt gacctaggtt
    12481 tgtatacaag acccttccct ccctcaaagt agattaccgt taccgaccgt ccaccattat
    12541 gtttatcacc cttcgagaac gatactccgg tcataacgct caggccctgt aggtaatcct
    12601 tcagtaactg ttgctcatcg ctgagcagcc tattaagcag ttctctcctg gaacgcactg
    12661 ttgtcagaac ccttgtcact aaccttctac caagcgtagc atactcctcg aacaactcct
    12721 catagaagga acttctgccc atcgtcgaag tatagtccgc taacgtatag cgcgaaccgg
    12781 catgctcgtg ctcgtgttta gctacatgaa cctccaagat tagggtctga gtcaccaaca
    12841 tcttaagttc gtcacgagga gccgcgcaga actgtttcac aaattcgtca cccaaacgca
    12901 tattctcaaa actcgctgca actcgcttta tttccgagtt gagttgattg ctaatatact
    12961 tttcaaaagg tcgaagaaag atctccaccg cgtcggttct actaccttgt ccgacaccgt
    13021 cgttctcctc tgtctccgta actagagcta gtatctggag gagtgtagcc acccaggttc
    13081 cgtctacgtt cgaatgaaca attgactggg aggaataatc gacgatgcca agccgcgacg
    13141 acatatcggc aagtgacttg aatccgtgtt cctgaagaaa tagttgctcg tcgccagcct
    13201 cgtaaccggg gtactgctcc agtatcatct tcattcgaac agctcccttc tctgtactga
    13261 cagattccgg tgttacaacg atttcctcat caataaaaga cgccttcttc gcgatggcct
    13321 cgatatccac gtctcctcct ggaaaactac acatagaact tgaactcgag tacactgtgc
    13381 tggggacaac cgcgactgag gttgtcccca gcacagtcag tacggaggct gtcatcccca
    13441 gtcctcagac tggggacgac ccatctcaca gcctcggttg ctgagtcagc aggtacagct
    13501 cgcataggcc gatggacatg gagtcttgtt caccgtaacg cagttaaacg cggtatgtcc
    13561 gcaatctcct cttgtcaggc caccgcaaca accgaggctc cagaagtcgc cgttattgga
    13621 gccagcgcca gcaagttctg agacactaga caacgttgct atgctcagtt ctgcgctgcc
    13681 acttgggtga tttgttgtag tcgcgctgtt cacttggtcc agacgcttgt aaggtgtctt
    13741 ccacatttcg atgatagtca ttatgatcat tccctgatgg tgctaaactt acgaaagaca
    13801 tgtatgcagg ttgaggcgcc aggagaatcg gtgcaccagt ttatgccgtt ggagcaagca
    13861 gaacatgttg tcatttcctc aaccacgtct ggttgagccc accgatggat accattacca
    13921 caagtatcca cgggtatcgg catgatacat acagttcttt atctcgggcg cgcatgttgg
    13981 gactctaacc gtttatacga tgctgttcat atgatcactt ccacaacttt tgattgcgtt
    14041 tcgtgtggtt gtctttagga ttcctggtct tcagagggag ttcctgcgtt acatactaca
    14101 gcaccccttt gaccctcgaa atgcgcatgt gccaaacaat gttgtgcaga tatagtttaa
    14161 gacagttaca gcaacaggga gttctttggc attgctctca agctccccca taagcagcga
    14221 ttctgggagg tcagcccttc ctgctggatc atacccaatg tctgacacaa tagttcgctg
    14281 cttactctgt gccggagttt gccaggttgt caatgtcggg aaactacttt ctgcccccac
    14341 ggtgttagta gaagtcatga cagattacct ttcttcaaga gtcatagcga tattagttgg
    14401 tggatggttg tttttcagca acatcccttg gtgaatgcgc cacaggttcc agcgcaggct
    14461 gttgtgtcaa aagtgaagca tcccaatgct actgtcgctc ctattcctat ggtccacgta
    14521 ccgaacttat tggcatcaga cccagcgccg cttgcggaga tctcttcggg tgacaaactc
    14581 gatctgccgc atacagcatt tgcaagagtc gccttaatgt tctgttcgcg ccgactgtgc
    14641 ggcgagtctt tataactgga ggaacacatc ttaacccttt cctagaaact gtctgttatg
    14701 ggatggtgta tggctagaat tagtgaaatg agcacataag ttgtctccta ctattgtttg
    14761 ctagtgataa ctgccttaaa caagttcaac cctgacgaat ccagatgacc gtatactgcg
    14821 catacaagca aagacacagt ttcatgtcaa ctatacgcta tcagtacccg gataacattt
    14881 gagctcggac atcttcgtac gttgccattc ccccttcttc tttgctgaag ttcactagcg
    14941 aaacagaaga accttcagtt gaggggagaa tcaacgtgtg gtcgctttcc agtgattcaa
    15001 ggagttcttt gtatctcctt tttttgacga ttgggccact tacggcgggt actatataga
    15061 caggtgcgac agtaaatgct atggccgcca aagccagatt actgctactg agctgcttta
    15121 ttttgaccat tgagttgagg gacgctggcg caacgagaac tttatccgcc cagtacgcta
    15181 gttccttatg agttgctttg ccgctgactt gccaggaact ttcgaggtat gtctgctgac
    15241 ctgttattgc tgacatagcg ttagtagaca ggaagtgctc agcactcgga gtcagtacac
    15301 atttgattga tatatcatga tcatttctta gttgcagcat ccatgcgggc atcagtgcag
    15361 cccccacagc tccggtgata actgtcagca tatgcaacac ggttttcttc tttctcggaa
    15421 gcaaaagttg tcgggataca gcgccgcagc tacagtctcc gctgcttgtt tatgtggcgg
    15481 aaatatcgtt ctgacgcaga atgacgagcg cggcatgggt atcgcatcat cagaccgttt
    15541 tcgacgtaac tgttgcttta atgtctcctt tggttgaaat atattttcag aagaatagca
    15601 gcgacgacac ttacagccac caataatggc ggagcagcct ctgcaactat gccgtcagag
    15661 atggttggcg ctcccaggag taagttgctc gatcgctgcg gagagttatt cagggtagcg
    15721 ctgacaaaca taactacatg catgtaactc attctttttg cccatttgat tttagtctcg
    15781 ctgatgtttc tcagccagta ccaccatgcg gcatgttcca gcatgagtgc cagcatcgct
    15841 actactggac ctgctgttgt ttctgatccg ttcggtaacc gctgcatcga caggtagatg
    15901 ctggccgcgt gcgcgcaaca gagcaaagcg cctgcaagaa aaagcagccg cacaaccatc
    15961 agtcttgaag gaataggctg ggtcttgcat gatgcctgtg cctgcaagtc ggaactcata
    16021 ggccacctct ccagttacgg aggctgattg gtgaggacgt ccttgtatct ttccggtcga
    16081 atccaaggta actgcccaag tccgaggacg caaggggggg ggcggcatga tgtcaagttc
    16141 agggcagtgt tgtttgtcac gtaacatagc ggccttaggc tacccttttc cgcatcgagc
    16201 cccgtcgatt caggctaggc gcctgcccgc gcaccaccag gatgagaccg ggcatggaag
    16261 cgagaccggt ctgagggcag ctacctcggc tggcactcac tggccaggcg ggcgatgtgg
    16321 agggtcaggt aggccagctc ggcgtcggtc aggcgcggcc cgttgagctc caggagggcg
    16381 cgcactcgcg tggcagcgcg gaaggccaga ggctgcgccc ggcggatcgg tgtgaccagg
    16441 tcctccaggg agtcagatat ctggcggccg tcctccagac ggacgaacag gtagcgcagg
    16501 tgggtggcga atcgcgcggt gctcatggcc tgctcgtcca cctggatccc caggacggcg
    16561 gagaccactc cgaggatctg ggtgatggtc ctggtcatgc gcaccgtggg ggcaaggtcg
    16621 gaaccggcga actgcgcgtt gaccaggtgc agtgccaggg tggtggcctc gccgtcctcc
    16681 agcctcaccc ccaggcgctc gcccaccagg acgaccgtct gccgccccca ccgggtctcc
    16741 tccgggtaga gctgctggac ctcccagcgc agcgggtgct ccacgctgat accggcccgg
    16801 ctgcgctcca cggcgaagcg caggtggtcg gcgacggcca acaccagtgc ctggctgacg
    16861 ccaacccgtc cctgggcacg caccggctcc agcgcttccg aggcgagccg cacggtttcc
    16921 agcggcgtct cggacaggaa ggacaccagc ctgggcacgg agtggtcggc gtcggggacg
    16981 aagacctccg agaccgaccc ggcgtccacc ggatccccca ggtgcctgcc gtagccgatg
    17041 ccccgtccca ggagcaccgc ctggcccgcg tcgcggtccc gggccagcac ggcgttgttg
    17101 ttgagcaccc tgacgatctg ccagtgcgca gccctgcttc ctgccgacat gcctgtgccc
    17161 ttccccgccg ctggctcagg cccgcctcac gtgaggtccc ctgacccggc tggctccctg
    17221 gccccccgga gagccgtagc cagctcctcg ccgtgcctga cgctggactg cgggtagagc
    17281 agcaccttgt cgtaggcgtc ggcgttagtg acgacgaccg gggtgagggt cctgtacccc
    17341 gccttggcga tcgcctcgcg atcgagctcc atgagcaggt cgccggccct cacctcctgg
    17401 ccggcctcga cgtggctggt gaagtgctgg ccgtcgagct cgacggtgtc gatgccgatg
    17461 tggatgagga gctcgacacc gtcctcagag atgagtccca gcgcgtgcct ggtggcggcg
    17521 accatgacca ccctgccgtc aaagggcgcg tagataccgt cctcaccggg ctccacggca
    17581 acacccttgc ccatggcacc ggaggcgaag acagcgtcgg ggacgtcgcg caggggcacg
    17641 aggtccccgg acaccgggct ggagacgacg tagcgctggg aggccgccgc cagctgctcg
    17701 tcatagctct cctcgcccag ctgggagacc atcgtgccgg gctccgcaga ggccccgttc
    17761 ccctcggcgg tgccgacgtc cctgcccgca ccactgacgt ccccggcgtt gtcagagtcc
    17821 ttgtcagagt cctgggggtc ctcgaagccg gtcacccaca ccaggacgat cgcgccaagg
    17881 aaggccacca ggcagccgat gacctcgccg accagcgagc tgggcacggt ctcggagtag
    17941 ctgttgagga tggtcagcgg gccgggcagg ccggcgtagg cgtaggagcg agagccgaac
    18001 agggccacaa cgaccgctcc ggccgcgccg gcggcgcagc ccatgacgaa gggccgcttg
    18061 agcctcaggg tgacgccgta gatcgcaggc tcggtgatac cgaagatgcc ggtgaccgcg
    18121 gccgagccag ccaccccgcg catctggcgc gagcgggtgc gggtgagcac gcccacggcg
    18181 gcccccacct ggccgatgac cgccgcggtc tggaaggcct ggaaggtgtc ctggccgtag
    18241 aggtcgtagt tggccaggac catgggtgtg accccccagt ggacaccgaa gatgacggcg
    18301 acctgccaca ccccgccgat gatggctccc gccacgacgg gggcgcgctc gaccagccag
    18361 ttgtacccgt tggcgatccc ggtggcgccc gcgctggaca gcgggccgat gaccaggaag
    18421 gtcaggggca ccatgatgac gaggcagaag aagggggtga acagctgcct ggcggccgct
    18481 ggcaggtact tgttgaggaa gcgctccagg taggacagca gccacacgag aatgaggggt
    18541 ggcagcaccg aggaggtgta gacggtgggt gacatgggga tggtgaggaa gctgacggtc
    18601 tccccctccg agatggagtc cgccagggtg gtccagtccg ggttcatgat ggccgcgcag
    18661 cacaggacgg cgatgaacat gttggtctgg aagtggcgcg aggcggtgat cgcgatgagg
    18721 acgggaagga acgtgaaggg cgtccaggac atgaaggaca gcacctggtc cgtcccggta
    18781 ccggtgaagg ccgggtggac catgcgggtg atgatcagtg ccccctggag gatgccggca
    18841 gccgcgagca cgtagatgaa gggggcgaag acgccggaca tcgtggcgat gacccggttg
    18901 aggacggact gcctggggac ctcggcctcc gcatcagcac ggttggcgag gtcgagctcc
    18961 tcggcgacgg cgtcgtagac ctcggtgacg tggttgccga tgacgacctg gaactggcca
    19021 cccgactcga cgacggtgat gacgccggcc atctgggaga ccttgtcctt ggctccctcc
    19081 ggcgtgctgg ccaggaccag ccgcagccgg gtggcgcagc gcgaggcctg gcggatgttg
    19141 tcgccaccgc cgacgacctt gatgatgtcg cgggcgagcc tggggtagtc gcgaaccttc
    19201 tcagccattg agaaacgctc cttcgagggg tcaacgtcga tgcacccggg caaccacaac
    19261 agccgcgcgc cacagcagca ctgacagtgc cgcacgggtc aggctggccc aggtgtggcg
    19321 ccacgccgcc cacgtcctga cgggacagca gcgggtacca cggtcgactt cgggttcttg
    19381 cctcgacgga gtaacaggcc cgacagccag catccaggct acgtggcacg acggcgccag
    19441 cacaagcccc tggcgctagc caggaggatc acggaacctt tcaggtcctc cgggatcccg
    19501 caacgacacc cggacagggc acgacaacac cccgggccat cgcaggcacc tcggcacgag
    19561 acacctcgcc ctcagcagag tcccaggtgt agtcccgcag ggacagcggc caggtcgggt
    19621 cagtcccccg gccccaccag cacctggcag cgctgctggg ccaccagcca cgctgccagg
    19681 tcacgcacct cctgggcagt gacctggtcc aggagacgca ggctctctcc catggagcgc
    19741 aggcgcccgg tcaccacctc gctgcggccc agtcggctca tcctggccag ggagtcctcg
    19801 cctcccagca ccatggcgcc acgcagctgg ccgcgagcgc gagccatctc ccgctgcgtg
    19861 gggccgtggg cggccagctt ctcgaactca ccgagcatga cagcccccac ctcctccacc
    19921 ttgcgcggcg cgcagcccgc gtacaggccg aaggcccccg ccccggcgta ggagatatca
    19981 aaggcgtagg tggtgtaggc cagcccacgc ctctcccgga cctcctggaa caggcgcgag
    20041 gacatgcctc cgcctagcac ggtggtcagc acgctcatgg cccagcggcg ctcgtcacgc
    20101 accggaatac cctggcaggc caggtagagg tgggcctgct ccgtgtcacg ccccaccctc
    20161 acatcgtgga cctccagggg cgtgacaggc tcggtctcga aacgacgtgg cctgggtgcc
    20221 accggggaag agtcccaccc cgcacgagcc aggtcctggc tgacccgctc gcacagctcg
    20281 tcatggtcca ccgctccggc agcagccacg accagggcgt cggaggcgta ggtgcgccgg
    20341 tagtggtccc acacggcctc gcgcggcacc tcggagacgg tctcgtagga cccgccgatc
    20401 ggccgaccca gcggggtccc gtccccgaag gcggcccggg cgaaggcctc ctgggcgacc
    20461 tcggcagggt cgtcggcggc ctcagccagc tcggagacga tgacgccgcg ctcggtctcc
    20521 acctcatcag ggtccaggag ggaggaggtg accatgtccg tcacgacgtc cagcgcgtcc
    20581 atggcgtcag gggccaggac ccgggcgtag taggaggtgt gctccttgga ggtggcggcg
    20641 ttggcctcac cgccgatcat gtcgaaggcc tcggcaatct cgctggcgct gcgagttgtg
    20701 gtgcccttga acagcaggtg ctccaggaag tgggtcgaac cctcctgccc gctggcctcg
    20761 tcgcgggagc ccacccccag ccacagaccg atcgccgtgg agcgcaggcc cggcaccgcc
    20821 tcggtgatga cgcgcacgcc gccaggaagc acgctgcgcc gcgtcagcgc cccgtcgtcc
    20881 tccagcgaga gctcggtgcc agcctgccca ggcacaccac gcaccagctc ggcctcggtg
    20941 tagccctcag agcgctgcgc gccgacgacg ggtgtccccg gcccggcccc cggggaggag
    21001 ccggtcgagg ggaccgtccc gcctgacgca ctgtctgccc taccgtcagt ggcacgagct
    21061 gtcgcgctgc gtgccgcact acctgctgca ctggtcatca ccggctgagc ctaccgaaca
    21121 gcgagggctc cggcagaccc gttccaggtg ccaggtgggc tggcgcgcag ccatcccttg
    21181 ctgacgcccc cacccggtcg ggctccgtcc aacctcgtga agaagccggc tgacgctatt
    21241 cctgacaccc cccacccagg cgagatccgt gccaggtggg ttggcacgga tcccgctgag
    21301 atggaactac tcacaggggt tgtcccaagc cacccggaga atgtgacagc acacgcataa
    21361 actgacctct tcgcgggacg gtgcggctgc ttgtcctgcc gggcgatccg ccttgaggct
    21421 gcactcaggc cgagcccccg ctcgtgcgtc actcttcttc tgagtccccc tcccgcagcg
    21481 gcgtgcgctc caccgagaca gcgccagcct gagaggtgag ccgggcgacg gcgtccctga
    21541 tgcgctggcc gaccgcggca tcaatgctgt cccagtacca cagggcacgc tccagcacct
    21601 cgggccgctc gacctggacc aggctgtccg agactgtctc caccagccgc tggcgctggg
    21661 cctcggtaaa gacgtcacgc accagggtgc cggcctggct gaagtcgtcg tcgtcctccc
    21721 ggagggtctg ggcagcgacc accatctcgc cgtcagcctc ccacccgtcc tccaggcggc
    21781 cctgctcgtc agcgtagggg cggccaccgg agttggcggc gtaggtcggc tggccgccag
    21841 agtggaagta gcgcatcggc ccgtcgaagg tgtaggtgtt ggcgcgctca cgcacctccg
    21901 gcaggggctg gttgaccgga agctggtcgt ggttgacgcc gagcctggcc cggtgtgcgt
    21961 cagcgtaggc gaagacacgg gccagcagca tgcggtccgg ggagaacccg atgcccggga
    22021 cgatgttgga gggggcgaag gctgcctggt cgatctgggc gaagaagttt gccgggttct
    22081 cgttgagcgt cagggtcccc acggtaatga gcgggtagtc cgcgtggggc caggtcttgg
    22141 tcaggtcaaa ggggttgatc cggtaggtct tggcctcctc gtagggcatg acctggatgg
    22201 acagcgtcca gctcgggtag tcgccccgct cgatggcctc aaacaggtcg cgtcggtgga
    22261 agtcggagtc tatcccggcc agctcctcgg cgtcctgacc agcccagttc tccacgcctt
    22321 ggttggtgtg gaagtggaac ttggtccaga acctctcacc cgcctcgttg atgagcatgt
    22381 aggtgtggga cccgtagccg ttcatgtgcc gccaggtgcg cggcaggccc cggtccccca
    22441 tgaggtaggc aacctggtgg gcgctctccg gggacagtgt ccagaagtcc cactgcatgg
    22501 tctggtcgcg caggcccttg tcccccaggc gcttctggct gcggatgaag tgggggaact
    22561 tcatggggtc ccgaaggaag aagaccgggg tgttgttgcc caccaggtcc cagttgccct
    22621 cggtggtgta gagcttgagg gcgaagccgc gcacgtcgcg ccaggtgtcg ggcgagccag
    22681 cctcccccgc gacggtggag aagcgcagca gtgcccgtgt gtgcgtaccg ggttggaggg
    22741 cggcagcctt ggtgtagcgg ctgatgtcgt gggtgatgac cagctcgccg aaggctcccg
    22801 agcccttggc gtggggcttg cggtcaggaa tgttctcgcg gttgaagtgg gccagggagc
    22861 tgaccaggtg gtggtcgtgg agcagcagcg gcccgtccgg gcccagggtg atgctgtggc
    22921 gctcgctcgt ggccggggcg ccgttggctg tcgtggaccc ggacccgcta ctcagattga
    22981 tcggcttttc caaagcatta cctcctcatt gacggtaaac acaatagaat cacaaggagc
    23041 ttcagatcac cagcaggttg cggccacagc caccaggagg agcgacaatc acgagaatgg
    23101 cgccagaaga cccacgccga cgaacacgct caccagcgtc agtcgtgtca cgacagagtc
    23161 ggcacctctg cctatccatc accttcctgt tgcgaattac cagccagcag gatcacggag
    23221 ccactggggc cagactgagc gcgcaccgag cacgcacggt ggggccgggc ctctcggccc
    23281 ggccccactc gcagcagtag ccagcagtga ccgacagcgc cagccaacga
//
