LOCUS       NZ_CP025227            26427 bp    DNA     circular CON 14-APR-2024
DEFINITION  Actinomyces wuliandei strain 299 chromosome, complete genome.
ACCESSION   NZ_CP025227
VERSION     NZ_CP025227.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces wuliandei
  ORGANISM  Actinomyces wuliandei
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3107761)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2017) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, No.155 ChangBai Road, Changping District, beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004010955.1-RS_2024_04_14
            Annotation Date                   :: 04/14/2024 19:14:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,606
            CDSs (total)                      :: 2,544
            Genes (coding)                    :: 2,496
            CDSs (with protein)               :: 2,496
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 18 of 48
            Pseudo Genes (incomplete)         :: 37 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 9 of 48
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1150800
            Orig. end                         :: 1177227
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025227.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26427
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="linaridin"
                     /region_number="6"
                     /rules="(cypemycin or cypI)"
                     /tool="antismash"
     cand_cluster    1..26427
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cypemycin or cypI)"
                     /kind="single"
                     /product="linaridin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26427
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16427]"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16427
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cypemycin or cypI)"
                     /neighbourhood="10000"
                     /product="linaridin"
                     /protocluster_number="1"
     gene            complement(64..1977)
                     /locus_tag="CWS50_RS04730"
     CDS             complement(64..1977)
                     /EC_number="4.1.3.27"
                     /GO_function="GO:0004049 - anthranilate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009749384.1"
                     /locus_tag="CWS50_RS04730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="anthranilate synthase component 1"
                     /protein_id="WP_127841854.1"
                     /transl_table=11
                     /translation="MTLPPPTVLTRATSYHRDAGLLLEHLAAASLVPTTAGADGTPRPC
                     DIVLLETADVTTKASRTTVMVLEASARLTCTGSTVTVEALPPAGADGRAAVERVRTALG
                     RYVVSEPAPGPTPQPALGPALQRTQQPTQASPSSGATPASSRAAEQVTLAFPDPPEDGS
                     LEERERLTATSTVEPLRVLAATEVDHPHLPLEAGVLAFDYLATVETLPEVATGANTCPD
                     YLFYDARIILVIDHPTRTATLVGASVDAPDLERRLEELAAAIDTATADTATDTAIDQAA
                     ALPRERPGHAAASKDSQGTEGSGDPAPQPPGPPAAPPQDPAPRAAVPATTLTAHPTVSD
                     SDFEALVDQMQGHIAAGDVYQVVPSRGFTMPCPNALAAYHRLRGSNPSPYMFYLGTPDF
                     ELLGASPESALLHSARTGRVAIRPIAGTRPRGLAPDGSIDHERDTRLELELRTDAKEVA
                     EHVMLVDLARNDVARVSVPGTRQIDDLMRVDRYSRVMHLVSEVSGQLAPDLDALDALRA
                     SMTMGTLTGAPKLRAAELIRTAEGVRRGSYGGSVGYLRGDGELDTCIVIRSAFVREGTA
                     LVQAGAGVVADSVPAAEAAETLHKARAVLEAVAAAQGAELVIDTDPDDTPVPAATAPEA
                     RH"
     gene            2320..3747
                     /locus_tag="CWS50_RS04735"
     CDS             2320..3747
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082742.1"
                     /locus_tag="CWS50_RS04735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_127841855.1"
                     /transl_table=11
                     /translation="MRQAVVVGSGPNGLAAAVTLAEAGLSVRVVEAGDRIGGGVGSEEL
                     TLPGLVHDTCSAFHPFGPVSPFMSRFNLAAEGLRWRWAPYELAHPLPDGRGAVLHRSVA
                     GTAAGLGRDGVAWARLLGPLAGHFDALSAEILQPVAHLPAHPLVLARYGASAALPAVVL
                     ARVWRGEAARALFAGAAAHALRPLGAAFSSAIGLALLAAAHGSGWPVAEGGSGAIRDAV
                     LRRARRAGVEIETGRRIRSRREVGPGSLLMLDTTPAAAAQILGDALPGHVARAYRAYRH
                     GPGVAKVDMAVAEGVPWRHLPSRQAGTVHLGGTLAQVAAAEREVWRGRMPQRPFILVGQ
                     QYLADPGRARGGVYPLYAYAHVPAGWPGDVTRLVMGEIERYAPGFRERVLASASLSALD
                     LQAANANYVDGDVIAGASTARQLVARPRPAANPYATGVPGAYLCSAATPPGAGAHGMCG
                     YLAARAALTEMGMGERR"
     gene            3744..5159
                     /locus_tag="CWS50_RS04740"
     CDS             3744..5159
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF019350.4"
                     /locus_tag="CWS50_RS04740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_127841856.1"
                     /transl_table=11
                     /translation="MTWLAGPGGQGAQDGHASGVHRAGRVGPGGQAGRVGLAGPGGQGT
                     AAAPTRRDRPRALPHDWWRRDLAVALLALVLCGVETEAVRSLGVLERGGTVVAAYGFAG
                     GLALLCVWRRRFPLSVAACVFLLFLVVNLTEPDVLNLLGNKAVLALVLFSTAAWAWPRR
                     RARTVLAALVAGLLLLGAVLTVRGAVASGLWSQPTLHLLPPGLALLIDNLLLNALWCGL
                     PVLAGTIAWHLVQERMLVEEQAALIDAQAEERRADAVADERLWIARDLHEVASRDVAAV
                     GVSAAALRRNLTSPPPEVAQGLQDMEAMSREAVRALRLVVGSLRQDDGGGLPPGLDSLP
                     GLVEELGRRGLRVRYSQVECCSGMTGRVPAAVGLSLYRVAQGSLSSVLASSTADEASLV
                     LRVLHQGAGHAAEVEVVDRGRRRETASGDRRGLLGVSERLAAHGGTAEIGPRLAGGYGV
                     RVRLPFRPVEELG"
     gene            5156..5827
                     /locus_tag="CWS50_RS04745"
     CDS             5156..5827
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009085178.1"
                     /locus_tag="CWS50_RS04745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_127841857.1"
                     /transl_table=11
                     /translation="MSQIRVLLADDHTAMRRGFALMLQAEPDIVVVGEAADGAAAVRQA
                     RALSPDVVLMDVQMPGVDGIKATEQVTGAGLAQVIILTAFDDDEALFSGLSAGAAGYLL
                     KTADPDEIAEAIRQVHRGHGQLAPEVTRRVLARLPHQGRGAAPSADLDSLTPREREVLR
                     LVAQGRTNQEIAEELIVGVTTVKSYLSACLAKLHARDRVQLVVLAYELGLVRPGEGGSP
                     S"
     gene            6094..6996
                     /locus_tag="CWS50_RS04750"
     CDS             6094..6996
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010613564.1"
                     /locus_tag="CWS50_RS04750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_127841858.1"
                     /transl_table=11
                     /translation="MLEVRHLVRRFGAVTAVEDMSLSVRRGEVVGFVGANGSGKTTTMR
                     MIMGVLAPHGGEVLWDSRPVDAAVRRRLGYLPEERGLYPKQAVADQLVYLGRLAGSSRS
                     QARQTAARLLEELGIEEYARSALESLSLGNQQRVQVAAASMNRPVALVLDEPFSGLDPQ
                     AVDQMAEMLRRDADRGVPVLFSSHQLDLVERLCDRVVVVDKGRVVAEGTPGQLRGEQDP
                     VVLIRLGDDAGWLRDEPGLEVRDIEGGKAVVRLGSWTTTDLLRAALRRGGVHELRPWQP
                     SLAEIFREVVSDANGTEDV"
     gene            6971..8278
                     /locus_tag="CWS50_RS04755"
     CDS             6971..8278
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024110.4"
                     /locus_tag="CWS50_RS04755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_127841859.1"
                     /transl_table=11
                     /translation="MPTAPRTSETAETTEQPGTTKRTTNQSGSHEQPAGAAARGAWLVV
                     AGREISVQLRSRTFLVTVVTTALGLMITISVSGFIASLMSGSGGGPTRVAVTDEAGTRL
                     VQRAQQLAEAADAGDTSRLEPREVADEAAARQEVLSGEAELAVVTGDGGEVILMVRSDP
                     SSPQASLVAEAWAQLRLEDNASAQGVPVEALLEGTQVSEVVLAPGEPSPGTVRLTGWVL
                     TGVFYLLAVMFGAQLAQVVLEEKQNRVVEIIASLIPVRALLYGKLAGSWVVSVVQMAAY
                     ACAALTGFWLRGSGVDLSRVSTVLVWFVVLLAAGLVGTNALWAVAGSMSTRSEDLAQTA
                     TPVTLLLMAVLPVGFLATGPAATVLSFVPLANVAAMPTRMLAGSVGWWEPVLSLVITLA
                     VFTPLLVMLATAVYRRSLMQTQGRLTMRQALRLPAD"
     gene            complement(8521..8700)
                     /locus_tag="CWS50_RS12905"
     CDS             complement(8521..8700)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS12905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_164860076.1"
                     /transl_table=11
                     /translation="MNELLDKVNSDTVVIVDRTQVPVLATPAAFLGGLAAGAKAAGALV
                     GAAAGGAAVGAATR"
     misc_feature    8955..8970
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.29"
                     /tool="antismash"
     misc_feature    complement(9264..9279)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.96"
                     /tool="antismash"
     gene            complement(9282..10004)
                     /locus_tag="CWS50_RS04765"
     CDS             complement(9282..10004)
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="CWS50_RS04765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_127841860.1"
                     /transl_table=11
                     /translation="MTGAPQYDQVMADLYDPFISRASDPTELVSRCAPYVRGRNTLEIG
                     IGTGRVALPLAEVAASYTGIDNSEPMLEHLLTKRLPESLLARLADVRLPLPFYSGEFEV
                     AVSAMGSLSYVDSLEEYADCLRHVREVLVPGGTLIAENYSLSTYRALSEAGPSRFPVPD
                     GQGWCEFQASWDGDLMETEARVHYPDGTDSLFRERVLVLGEGEFESLARQAGFDPVQAE
                     YATHGAPFDWFALKRGTP"
     gene            complement(10001..10540)
                     /locus_tag="CWS50_RS04770"
     CDS             complement(10001..10540)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="DUF5819 family protein"
                     /protein_id="WP_127841861.1"
                     /sec_met_domain="cypI (E-value: 3e-25, bitscore: 86.4,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALLRRLLPAVFAVWLVVTALSQHPDRSFDRVRQVDRTGTGLLI
                     PNWRFFAPNPAVHDQHFLYRLANEDRSDHTPWMSVYEAEPRRWWHAFWFPARRMEKSIF
                     DAASTILNNQAASVPTEKEAVESAKRLVTSFVRARVTPREGYPYFQVLLVRYSGYDHSE
                     NPLYDMVFDYEPVEAS"
     misc_feature    complement(10517..10519)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10537..11520)
                     /locus_tag="CWS50_RS04775"
     CDS             complement(10537..11520)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (62-167). E-value:
                     1.6e-12. Score: 39.5. Matches aSDomain:
                     nrpspksdomains_CWS50_RS04775_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="CWS50_RS04775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_127841862.1"
                     /sec_met_domain="PF00561 (E-value: 3.3e-08, bitscore: 30.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.4e-16, bitscore:
                     58.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVMRDTVTVTAAALGIGLAHQAYATARSLRRHSGYEHHVVSCRS
                     GNELSCYRGDSAGDSRATVLFASGLMNTSTSWLLLASHLSGMTPVLYDRAGYGRSLWRS
                     EAPYHLQESVADAADVVKEVCSGDDPIWLAGHSMGGYLVHRLAGQLDNIAGVILIDPMH
                     PREMVVSQPQREGAKATDLTLRTAPLPVALGAGLLMDKGGVLSSAAGSPSLGRLRAEIS
                     AASTWYAAAREWRYLYPYLLDGGAPLEQVATPVYVIAAEATVAGSSEQGGLYDEYVASG
                     SAGGRRLDLEDCDHLSIINAPQAAPRLAEQVVSLVQERPEPREVTS"
     aSDomain        complement(11020..11334)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CWS50_RS04775_Abhydrolase_1.1"
                     /evalue="1.60E-12"
                     /label="CWS50_RS04775_Abhydrolase_1.1"
                     /locus_tag="CWS50_RS04775"
                     /protein_end="167"
                     /protein_start="62"
                     /score="39.5"
                     /tool="antismash"
                     /translation="TVLFASGLMNTSTSWLLLASHLSGMTPVLYDRAGYGRSLWRSEAP
                     YHLQESVADAADVVKEVCSGDDPIWLAGHSMGGYLVHRLAGQLDNIAGVILIDPMHPRE
                     M"
     CDS_motif       complement(11071..11133)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CWS50_RS04775_0001"
                     /evalue="6.00E-06"
                     /label="NRPS-te1"
                     /locus_tag="CWS50_RS04775"
                     /protein_end="150"
                     /protein_start="129"
                     /score="18.8"
                     /tool="antismash"
                     /translation="PIWLAGHSMGGYLVHRLAGQL"
     gene            complement(11517..12362)
                     /locus_tag="CWS50_RS04780"
     CDS             complement(11517..12362)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841863.1"
                     /transl_table=11
                     /translation="MPAPRPVVDSVLSRALGAPLGTAERVSAVCQLLSSAEYLVRRADR
                     AKGGLNDWSLARDQVPSRLQLTRRMRDLVATEAVTSGLHVAQVGAGLVLLSPVRHQGVR
                     AGADLLLAGSQLLLYPRHLYGTDGSDQVSFLVAAAAGLGRAGGTAGTRRAAIEFIGAQT
                     ILSYSAAGITKMPGALWKSGDALVSIMRTQTYGDEGFYRLLTRFPRSARALCRGVVAFE
                     ALFPLLAVGRGRYMDWGLAVMAAFHAANARFMGLSRFSWAFVSTYPAVRSLVRREEVSA
                     "
     misc_feature    complement(12165..12167)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12922..13302
                     /locus_tag="CWS50_RS04785"
     CDS             12922..13302
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020947.4"
                     /locus_tag="CWS50_RS04785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2000 domain-containing protein"
                     /protein_id="WP_127841864.1"
                     /transl_table=11
                     /translation="MATDQQKTVIVVDRHLPVGLAVNAASIVSAMVASACPQIMGPSVR
                     TADSELPGVVLTPLPVLAGDSGLLASVWSRAEAQGSGVDVFPFTRLAQGCRTYEEYVSR
                     LGSALTRDLELAAHVTWSWRHT"
     misc_feature    13434..13448
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     misc_feature    14098..14115
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            14963..15859
                     /locus_tag="CWS50_RS04795"
     CDS             14963..15859
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="CWS50_RS04795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_127841865.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.8e-07, bitscore:
                     29.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGFERGLVASACSVIGASQAVQLSQYSLERTRRNGLNGPSLARM
                     DDGSVVEFIYENAQDSDHVVIFENGLGECLEAWDWVCHVLGDKYGTLRYHRAGYGRTTA
                     TISAPKILEQLYSNYCAGKSVTIVAHSIGAFFFAQHMAYGGEVSHAVKKVVLIDTTKFD
                     TFLTERNDLVRSGRFLQSLVQTGVSTVAGTHAWSTNQVDRELDYRPDIRRAVFLFSRSL
                     STLRNSWREYRSTVVPDLRTIAAPECHVLAAEDNVDEQKGVANDLGARFDVVAGSAHHS
                     IIGKLECVEEVCRIVWG"
     misc_feature    15215..15217
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15506..15508
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15635..15637
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15818..15820
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15954..16427
                     /locus_tag="CWS50_RS04800"
     CDS             15954..16427
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     linaridin: cypI"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841866.1"
                     /sec_met_domain="cypI (E-value: 3.6e-18, bitscore: 63.6,
                     seeds: 22, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSKTPFLPQPPQWKFFAPNPGVENYYVFYRFRSKEDAESAGAGA
                     WRVFPMTRQSKWYSFLWNSGSRRGKALFDVVQQVRILAGHSGSYEWAKRSQAFIILEKI
                     IEKHIGAIRKSERPEEAGREGPSHYQFMIMGSLPAAGEDGFKPIAVSPWIEIS"
     misc_feature    16167..16169
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16475..17074
                     /locus_tag="CWS50_RS04805"
     CDS             16475..17074
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Flavoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014494.4"
                     /locus_tag="CWS50_RS04805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="flavoprotein"
                     /protein_id="WP_257493438.1"
                     /sec_met_domain="Flavoprotein (E-value: 9.2e-13, bitscore:
                     45.5, seeds: 143, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGNAPSVRASSLHLWITGSISASLVPYWMRWIIETYHGIHISATV
                     SHAATRFVAPEAVHQIARDTGGWAALDDWDESGPTGRLSHADIAMAAEAFLVFPGTVNS
                     VMSLACGLSSTPSMLALQVSEKPLVIAASFPCMNTVLSSGLEKLNERANVAFSPLVLAK
                     GVSSGKWSELSGLFAPLVMAELGTLEEELYDGRRSE"
     misc_feature    16808..16810
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16907..16909
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17151..17888
                     /locus_tag="CWS50_RS04810"
     CDS             17151..17888
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CWS50_RS04810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_243118514.1"
                     /transl_table=11
                     /translation="MSAAEHVVTSLVRPVALRPGVEYIHTSGLSVGFEGHPVCSSVDLK
                     VGPGEALFVVGANGAGKSTLLRTCLGLQPAISGSSLVMGEVADPRSSLQRSCVARDLGD
                     EAFFPSLSVREHLELVSYGHGVKNARSIVESVMEEMGLLAVADSVPDRLSSGQRRRLSL
                     SSVLVRPRSILVLDEPEQRLDAATRKALAGYLNAEREAGGALLVVSHDPVLVEASASAV
                     LVVGSETMIYDVGAGVLALKEGT"
     misc_feature    17454..17456
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17505..17507
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    17790..17792
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17885..19450
                     /locus_tag="CWS50_RS04815"
     CDS             17885..19450
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841869.1"
                     /transl_table=11
                     /translation="MSSVPDLYQLRAWTRVRVTERRRSSLTKTDGFSDIYVLMLGVGVW
                     APMLFHFFARSDVRLSPVYVDTFTGITRFSPMWFGTGTALLGAAACVGALRRLGPLFLR
                     VEETIWWLSCPGDRGHLMRLLARRIVAGGALVGAVAAAALVWLLGGDAFGVAGAAGSAA
                     SMIACGLVLTVRSQVINRGAGVLRLFFLMVATIAICISGIFVDSSPYRMWIVGCSVLAT
                     VAGTYAAWLVTAPSLGSVPDVILSESAQRGASLRAVGLALDTRGLGFVLAPPVRRPLRP
                     DSLAVVRWALLGEGLFRWIFTGSRSRSVLGVVQADLLLLRRQPWRTVTALCLAVIAGLL
                     LLFDAYGFGLAMLLVFAWLVSLICADAARRAQRDDAPDSLWPAAPVWVRLGHFIIPALF
                     MIFWWCAVDLVVVFGSAIMNDDVPGELLVAGFLSGPGWAGVSLRSGFRRDSDWSMSVPT
                     PVGLIPIGLLQSVTVGPDAAVVLVIPVLIADTLSVSMSLCLAQLGLSFLVVILGFLTGR
                     DNMR"
     misc_feature    18455..18457
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18662..18664
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18719..18721
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    18959..18961
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19076..19078
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19283..19285
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19286..19288
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19403..19405
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19910..20440)
                     /locus_tag="CWS50_RS04825"
     CDS             complement(19910..20440)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010615017.1"
                     /locus_tag="CWS50_RS04825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VTT domain-containing protein"
                     /protein_id="WP_127841871.1"
                     /transl_table=11
                     /translation="MMDRIHELPYPGVFLFFWCLAMMRSHTMYWMGRGVTAGTARTRWA
                     RVLESPVYARAQAWSARWGVLAVPLSFLTVGLQSAIQLSAGVTRMPLHRYALATAVGAL
                     AWAGVYTTIGMAVLAAWYTSPAGRVVAVAAVCVLAAIIVARYRRARRGCVPATPTANST
                     AQEQRNHSPAAPA"
     misc_feature    complement(20423..20436)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 19.79"
                     /tool="antismash"
     misc_feature    complement(20441..20459)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 25.45"
                     /tool="antismash"
     gene            20817..23762
                     /locus_tag="CWS50_RS04830"
     CDS             20817..23762
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009054729.1"
                     /locus_tag="CWS50_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="WP_127841872.1"
                     /transl_table=11
                     /translation="MLSINWNDVWNVVASLRPQLIAIGVVLLLAVVVTVAVRRRDRPVR
                     KLVRSTTWVAAALAVAVAVTSMMYGGLRTILDLSSGAGTLSEETSATVEELGNTISEEG
                     MVLLKNTDGALPLEEGSALNVLGWASTNPIYGGTGSGSLSPDNPTTTLLDGLHNAGFTT
                     NEELTSLYTGYRAERPEVGMFEADWTLPEPTSQAYTSDVVTGLEEFSDTSVVTIARSGG
                     EGFDLPQDVNAEVADNPAFSYTDNAEDTPDFADGQGYLELTAPERDLIELAKTSSQTTV
                     VVINSANAMELGELEADPDIDAIIWAVPGGQVGFNALGRILDGEVNPSARTPDTFVTDI
                     TSSPAANNFGDFTYTNMEGYGQTSPFTDTTTYPGFVSYVEGIYVGYRWYETAAAEGVID
                     YDKEVVYPFGYGLSYTTFRQEMGEVTYADGTVSFDVTVTNTGDVAGKDVVEAYYTAPYT
                     DGGIEKSAVDLADYAKTGLLEPGASETVTISFDDDDMASYDSQDAKAWVLEAGDYTVSI
                     RSDSHTVIDSAEVTVPGTVTYTGETTHDGDAVAATNQFDDAAGDVTYLSRADSFANYEE
                     ATAAPSSLEMSQEHRESFVANDTYDASQEDDPDAEMPTTGADNGLVLGDMHGLDYDDPQ
                     WDRLLDQLSVEEMNDLIAHGGYGSVAVDSVGKVRVSDVDGPASLNNNFTGVGSIGLATA
                     VSVAATWNKEIAHDFGTAIGTMAHDMDVAGWYAPATNTHRYAYAGRNFEYFSEDPVLAG
                     NQVAQEIQGAKELGVYAFVKHFAFNDQETNRTNMLVTWSQEQALREIYLRSFEIGIKEG
                     GAGAVMTAFNYIGTTYAGASPALQQAVLRDEWGFRGMTLTDYFAGYGYQNADQLVRNGG
                     DMMLATTDIGVNFVQHTSAAGVQAMRTASHNILYTVASSWVYEDGQPETQRASWEYVTW
                     AVLGVLGVVLLGLEALAVRRFLARRRQAAAQAADGAAAQPSGSSGSAGSAE"
     misc_feature    23871..23886
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    complement(23879..23891)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.83"
                     /tool="antismash"
     gene            23919..26321
                     /locus_tag="CWS50_RS04835"
     CDS             23919..26321
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009211928.1"
                     /locus_tag="CWS50_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 3 protein"
                     /protein_id="WP_127841873.1"
                     /transl_table=11
                     /translation="MTPDPRDLTLLEAAALLSGASEWQSRALPARGVRSFVLSDGPHGV
                     RRQLGSGDHLGIAASQPATCFPTAATVANSWDPELAEEMGAALGQEARALGVDVLLGPG
                     LNIKRSPLCGRSFEYYSEDPLLSGRMAAGVVRGIQSQGVAATPKHFAVNSQELRRMASD
                     SVVDERTMRELYLTAFEIVVREAAPRALMSAYNKVNGVYANENHHLLTEILRQEWGFDG
                     MVVSDWGGSNCAPAAAGAGSSLEMPAPGLHSAREVVAAVESGELSHEQVQARAAEVLAL
                     AEAASSHGQRPGLGAREHHHLARRVAEESIVLLRNEDAILPLAPGTRVAVIGDMARTPR
                     YQGAGSSQVNPVRLENLLEAVGETELELVGYAQGYQRDGTPDPVLSRRAAVLAARAEVA
                     LVCLGLDELSESEGLDRSHMRLPQAQTRVLAEVARANPRTVAVVSAGSAVETHWEAHAR
                     AVVHTYLSGQAGASATLRVLTGAVNPSGRLAETYPVRYEDHPVAAWFPATGEHALYREG
                     PYVGYRYFTTTGTPVAHPFGFGLSYSSFDYSDLEVDAQGARFTLTNTSQVDGAEVAQLY
                     VRPPGGLWGPSIQLKGFAKVWLEAGQSCKVRVPFDRYTFRHYDVGEQAWCVEGGTWTVE
                     VGRNVEDLPLRAELEVEGTRPQPACQELGPYLTGEVTQVSDAQFRALLGRPLPVARTGR
                     EVGVNDPVSSLAQARSLLARAAVRVLTWRRARAEARGRPDLNILFLLNMPLRAMAKMTS
                     GMVDGEMVEGVVDIANGHPLRGVRRTAVGYLRNRRADRVTRRELSGC"
ORIGIN
        1 gcgaactggt ccaccaggtt gtagacgaag gagtcgcggt tgtcgagcag gaccacgtgc
       61 atatcagtgc ctcgcttccg gtgcggtggc cgcggggacc ggagtgtcgt ccgggtcggt
      121 gtcgatgacg agctcggccc cctgggccgc agcgacagcc tccaggaccg cccgggcctt
      181 gtggagggtc tcagcggcct cggcggccgg cacggagtcg gccacgactc ccgccccggc
      241 ctgcaccagc gccgtcccct cacgcacgaa ggcggagcgg atgacgatgc aggtgtcgag
      301 ctccccgtcg ccacgcaggt acccgaccga gccgccgtag ctgccgcgcc gcaccccctc
      361 ggcggtgcgg atgagctcgg cggcgcgcag cttgggggcg ccggtgaggg tgcccatggt
      421 catggaggcg cgcagggcgt ccagggcgtc caggtccggg gccagctgcc cgctgacctc
      481 ggagaccagg tgcatgacgc gggagtagcg gtccacgcgc atgaggtcgt caatctggcg
      541 ggtcccggga acgctcaccc gcgcgacgtc gttgcgggcc aggtccacca gcatgacgtg
      601 ctcggcgacc tccttggcgt cggtgcgcag ctccagctcc aggcgggtgt cgcgctcgtg
      661 gtcgatgctg ccgtcggggg ccaggccgcg tgggcgggtg ccggcgatgg ggcggatggc
      721 gacccgcccg gtcctggctg agtgcagcag ggcggactcc ggggaggccc ccagcagctc
      781 gaagtcaggg gtgcccaggt agaacatgta ggggctcggg ttggagccgc gcagccggtg
      841 gtaggcggcc agggcgttcg ggcacggcat ggtgaagccg cgtgagggca ccacctggta
      901 gacgtccccg gcggcgatgt ggccctgcat ctggtccacc agggcctcga agtcgctgtc
      961 ggagacggtg ggatgggcgg tcagggtggt ggccggcacc gctgcccggg gggccgggtc
     1021 ctgcggaggg gctgctggag gccctggcgg ctgcggggcc gggtccccgg agccctcggt
     1081 gccctgagag tccttggagg cagcggcgtg cccggggcgc tcccggggga gggcggccgc
     1141 ctggtcgatg gcggtgtcgg tagcggtgtc ggcggtagcg gtgtcgatgg cggcagccag
     1201 ctcctccagg cgccgctcca ggtcaggggc gtccacggag gcccccacca gggtggctgt
     1261 gcgcgtgggg tggtcgatga ccaggatgat gcgggcgtcg tagaagaggt agtcggggca
     1321 ggtgttggcg cccgtggcca cctcgggcag ggtctcgacg gtggccaggt agtcgaaggc
     1381 gagcacaccc gcctccaggg gcaggtgggg gtggtccacc tcggtggcgg ccaggacacg
     1441 caggggctcg acggtggagg tggcggtgag ccgctcgcgc tcctccaggc tgccgtcctc
     1501 gggcgggtcc gggaaggcca gggtgacctg ctcggcggcc cggctgctgg ccggtgtggc
     1561 cccggaggag gggctggcct gcgtgggctg ctgcgtgcgc tgtagcgcgg ggcctagagc
     1621 gggttgtggc gtggggcctg gtgcgggctc gctgacgacg tagcggccca gggcggtgcg
     1681 cacccgctcc acggcggcgc ggccgtcggc tccggcaggg gggagggcct cgacagtgac
     1741 ggtagagccg gtgcaggtca gccgggcaga ggcctccagg accatgacgg tggtgcggga
     1801 ggccttggtg gtgacgtcgg ccgtctccag cagcacgatg tcgcaggggc gcggtgtgcc
     1861 gtcggcgccc gcagtggtgg ggaccaggct cgccgcagcc aggtgctcca gcagcagacc
     1921 cgcgtcgcgg tggtagctgg tggcccgtgt cagcacggtg ggcgggggaa gcgtcatgag
     1981 ggccttcctg ttcgtgccac cagcaggacc cgcccgttga cgcgcaggac ctcgcccggt
     2041 ggcgagctct tgcggtgcgg tgccgactgc acggagtcag cggctgcggg tggctcgcct
     2101 cctggggagc caccaccact ggctggtgcg gggcgtggtc atggccgaac cctatgacgg
     2161 gcggggccgt gcgcacaagc ggggcaccac tggagtggtg gcatctccgg cgcagcgaca
     2221 ggggtcttga cacggtttct aggtcacggg tagcgtcaca cggagacgtg gcctgcgggc
     2281 tgctgagcca gtgcttggcg aggagttggc gaggagccta tgaggcaggc agttgtcgtg
     2341 ggcagcggcc ccaacgggct ggctgccgct gtgacgctgg ccgaggctgg cctgtccgtg
     2401 cgcgtggttg aggcgggtga caggatcggt ggcggtgtcg gctcagagga gctgacgctg
     2461 cccgggctgg tccatgacac gtgctcggcg ttccacccct ttggcccagt ctctcccttc
     2521 atgagccgct tcaacctggc ggcggaggga ctgcggtggc gctgggcacc ctacgagctg
     2581 gcccacccgc tgcccgacgg gcgtggggcc gtcctgcacc gcagcgttgc gggcacggcg
     2641 gctggcctgg gcagggacgg ggtggcctgg gccaggctgc tcggtccgct ggccggtcac
     2701 tttgacgcgc tgtcggcgga gatcctccag cccgtggcac acctcccggc ccacccgctg
     2761 gtcctggccc ggtacggtgc ttctgctgcg ctgcccgcag tggtgctggc gcgggtgtgg
     2821 aggggcgagg cggcccgcgc cttgttcgcc ggtgccgctg cgcacgccct gcgcccgctg
     2881 ggggcggcct tctcctcggc catcgggctg gcgttgctgg cggcggccca tggcagtggg
     2941 tggccggtgg ccgaaggagg ttccggcgcg atcagggacg cggtgctgcg ccgggcgcgg
     3001 cgtgcggggg tcgagatcga gaccgggcgg cgtatcaggt cacgcaggga ggtggggccg
     3061 ggcagcctgc tcatgctgga caccaccccc gccgcagccg cccagatcct tggtgacgcc
     3121 ctgccggggc acgtggcgcg ggcctaccgg gcctaccggc acgggccggg ggtggccaag
     3181 gtggacatgg ctgtggccga aggggtgccc tggcggcacc tgccttcccg gcaggcgggc
     3241 acggtccacc tcggggggac cctggctcag gttgctgccg ctgagcggga ggtctggcgc
     3301 gggcggatgc cgcagcgccc cttcatcctg gtgggccagc agtacctggc cgacccgggc
     3361 cgggcccgcg ggggcgtgta ccccctctac gcctacgccc acgtcccggc aggctggccc
     3421 ggtgacgtca cacggctggt catgggcgag atcgagcgct acgccccggg cttccgcgag
     3481 cgtgtcctgg cctccgcctc cctctcggcc ctcgacctcc aggcggccaa cgccaactac
     3541 gtcgacgggg acgtcatcgc gggcgccagc acggcccgcc agctggtggc gcggccgcgc
     3601 cctgccgcca acccgtacgc caccggtgtg cccggggcct acctgtgctc ggctgccacc
     3661 ccgccgggtg ctggcgcgca cggcatgtgc ggctacctgg ccgcgcgggc cgctctcacg
     3721 gagatgggga tgggggaaag gcgatgacct ggctggctgg tccgggcggc cagggcgccc
     3781 aggacggtca cgcgagcggt gtgcaccggg cagggcgcgt cggcccgggc ggtcaggctg
     3841 gccgggtcgg gctggctggt ccgggcggcc agggcaccgc tgccgccccg acccgcaggg
     3901 accgcccaag ggcactgccc cacgactggt ggcggcgcga ccttgcggtc gccctcctcg
     3961 ccctcgtgct gtgcggggtg gagaccgagg ccgtgcgcag cctcggcgtg cttgagcgcg
     4021 gcggcacggt tgtggcggcc tacggcttcg cgggcgggct ggccctgctg tgcgtgtggc
     4081 ggcggcggtt ccccctgagc gtggccgcct gcgtgttcct cctgttcctg gtcgtcaacc
     4141 tgactgagcc cgacgtgctc aacctgctgg gcaacaaggc ggtcctcgcc ctggtgctgt
     4201 tcagtaccgc agcctgggcc tggccgcgtc gccgggcgag gaccgtgctg gccgccctgg
     4261 tggcaggcct cctccttctg ggtgcggtgc tcacggtgag gggtgcggtg gccagcggcc
     4321 tgtggtcgca gccgacgctc cacctgctgc cccccggcct ggccctgctt atcgacaacc
     4381 tgctgctcaa cgcgctgtgg tgcgggctgc cggtgctggc gggcaccatc gcgtggcatc
     4441 tggtccagga gcggatgctg gtggaggagc aggccgctct cattgacgcc caggctgagg
     4501 agcgccgggc cgacgcggtc gctgacgagc ggctgtggat cgcccgcgac ctgcacgagg
     4561 tcgcgtcacg cgacgtggca gccgttggtg tgtcggcggc ggcgctgcgg cgcaacctca
     4621 ccagccctcc cccggaggtg gcccaggggc tgcaggacat ggaggcgatg tcgcgcgagg
     4681 cggtgcgtgc cctgcgcctg gtcgtggggt cgctgcgcca ggatgacggg ggcggcctgc
     4741 ccccgggcct ggacagcctc ccggggctgg ttgaggagct gggccgccgt ggcctgagag
     4801 tgcgctactc gcaggtggag tgctgttccg ggatgaccgg cagggtcccc gcagcggtgg
     4861 gcctgtcact gtaccgggtg gcgcaggggt ccttgtccag cgtgctggcc tcctctaccg
     4921 cggatgaggc ctccctggtg ctgcgggtgc tgcaccaggg cgcgggccac gccgccgagg
     4981 tcgaggtggt ggaccgggga cgcaggcggg agaccgcctc cggtgatcgg cgcggcctgc
     5041 tcggtgtctc ggagcgtctc gccgcccacg gcggcacggc tgagatcggc ccccgcctgg
     5101 ctggcgggta cggtgtgcgg gtgagactgc ccttccgtcc ggtggaggag ctgggatgag
     5161 ccagatccgg gtgctcctgg ccgatgacca caccgccatg cgccgaggct tcgcgctcat
     5221 gctccaggcc gagcccgaca tcgtggtggt gggagaggcc gctgacggtg cagccgcagt
     5281 gcgccaggcc cgcgcgctga gccccgacgt cgtcctcatg gacgtgcaga tgcccggcgt
     5341 ggacggcatc aaggccaccg agcaggtgac cggggcagga ctcgcccagg tcatcatcct
     5401 cacggccttt gacgacgacg aggccctgtt ttccgggctg tcggccgggg ctgcgggcta
     5461 cctgctcaag accgccgacc cggacgagat cgccgaggcc atccgccagg tccaccgggg
     5521 ccacggccag ctggcgccgg aggtgaccag gcgggtgctg gcccgcctgc cgcaccaggg
     5581 gcggggcgcg gcgccgtccg ccgatctcga ctccctgacc ccgcgggagc gggaggtgct
     5641 gcgcctggtg gcccaggggc gcaccaacca ggagatcgcc gaggagctga tcgtgggtgt
     5701 cacgacggtc aagagctacc tgtcggcgtg cctggccaag ctgcacgccc gcgaccgcgt
     5761 ccagctggtg gtcctggcct acgagctcgg gctcgtgcgg cctggcgaag gcggttcccc
     5821 gtcctgatcc tggctcgcgc ggcggcagcc tgccgggtgc agccgggagg ctgcgcgggt
     5881 cgaggcagct gtctcacgtg ggcacgagac ctgccaggtg tgcggctggg tctgctcctt
     5941 cgtggggagg ggcggtgggc tgtgagctct ccttcctcgg cagggggagg ttccggctcc
     6001 cggcaggatg aggtctgggg tggctgctcc tagcctggtg gttggcaagg agacactgac
     6061 aggcggtgac agggagacag caaggaggtg gcgatgctgg aggttcggca cctggtgcgg
     6121 cgcttcgggg ccgtgacggc ggtggaggac atgagcctca gtgtgcgtcg tggcgaggtc
     6181 gtcggcttcg tgggggccaa cgggtcgggc aagaccacga cgatgcgcat gattatgggc
     6241 gtcctggccc cgcacggagg ggaggtcctg tgggactccc gccccgtgga cgccgccgtg
     6301 cgccgccgcc tgggctacct gcccgaggag cgcggcctct accccaagca ggcggtggcc
     6361 gaccagctgg tctacctggg caggcttgcg ggcagcagcc ggtcccaggc ccgccagacc
     6421 gccgcacggc tgctggagga gctcggtatc gaggagtacg ccaggtctgc cctggagtcc
     6481 ctctccctgg gcaaccagca gcgggtccag gtggcggcag cctccatgaa ccggcccgtg
     6541 gcgctcgtgc ttgacgagcc gttctcaggg ctggacccgc aggccgttga ccagatggcg
     6601 gagatgctcc gcagggacgc cgaccgtggg gtccccgtcc tgttctcctc ccaccagctg
     6661 gacctggtgg agcgcctgtg tgaccgggtc gtcgtcgtgg acaaggggcg ggttgttgct
     6721 gaggggaccc ccgggcagct gcgcggcgag caggaccctg ttgtcctcat caggcttggg
     6781 gacgacgccg ggtggctgcg cgacgagcct ggtctcgagg tccgcgacat tgagggaggc
     6841 aaggctgtgg tgcgcctggg ctcgtggacc acgacggact tgctgagggc ggccctcaga
     6901 cgtggtggcg tccacgagct gcgcccgtgg cagcccagcc tggcagagat cttcagggag
     6961 gtggtcagcg atgccaacgg caccgaggac gtctgagacg gctgagacga ctgagcagcc
     7021 ggggacgacg aagaggacaa cgaaccagtc tggctcgcat gagcagccag cgggggctgc
     7081 tgcgcgcggg gcctggctgg tggtggccgg gcgggagatc tccgtccagc tgcgcagcag
     7141 gacgttcctt gtcaccgtgg tgacgacggc cctggggctg atgatcacca tctccgtgag
     7201 cggatttatt gcgagtctga tgagcgggtc cggcggtggc cccacgcgtg tggccgtcac
     7261 cgacgaggcg ggcacccgcc tggtccagcg tgcccagcag ctggctgagg cggcagatgc
     7321 aggggacacg agccgcctgg agccccgcga ggtggctgac gaggctgctg cgcgccagga
     7381 ggtgctctcc ggcgaggccg agctagccgt ggtgactggc gatggcggcg aggtcatact
     7441 catggttcgc agtgacccgt cgtcgccgca ggccagcctg gtggcagagg cgtgggcaca
     7501 gctccggctg gaggacaacg ccagcgccca gggcgtgccg gtagaggcgc tgctggaggg
     7561 cacgcaggtc agcgaggtgg tcctggcacc gggagagccc tcgccaggga ctgtccggct
     7621 caccggctgg gtcctgaccg gggtgttcta cctgctggcg gtgatgtttg gtgctcagct
     7681 ggcacaggtg gtgctggagg agaagcagaa ccgggtggtg gagatcattg cctccctgat
     7741 cccggtgcgc gccctgctct acggcaagct ggcgggcagc tgggtggtct ccgtggtcca
     7801 gatggccgcc tacgcctgtg ctgctctgac gggcttctgg ctgcgaggct ccggggtgga
     7861 cctgtcacgg gtcagtacgg tgctggtctg gttcgtggtg ctgcttgcgg ccggtctggt
     7921 ggggaccaac gccctgtggg cggtggcggg gtcgatgtcc acccgtagtg aggaccttgc
     7981 ccagacggct acaccggtca cgttgctgct catggcggtg ctcccggtcg ggttccttgc
     8041 cacgggtccg gccgcgacgg tgctctcctt tgtcccgctg gccaacgtgg ccgcgatgcc
     8101 cacaaggatg ctggcaggca gtgtcggctg gtgggagccg gtcctctccc tggtgatcac
     8161 gctcgctgtc ttcaccccgc tgctggtcat gctggccacg gctgtctacc gccgctcgct
     8221 catgcagacc caggggcgcc tcaccatgcg ccaggcgctg cgtctgcctg ccgactgact
     8281 aagccttttc tgacggtaaa gcacacggct tcttcttcgc gttccgtggc agcccagacg
     8341 tagttttcgc cgtcatcgtt gtcctaggta aggttgagcc gcaactctgt cgccaacgag
     8401 aaaggtagca gcaggacagg cgcctggagc aactgcctgc ggtgtcagtg ctccaggcgc
     8461 ctgtatgtcg ccgtgggttc ggtgctgagt ttccgccaca cgccacgaga tgggactgga
     8521 ctagcgggtc gctgcgccaa cggccgcacc gccagcagcg gcgcccacca gggcgcctgc
     8581 agccttggcg cccgcagcta gtccccccaa gaaagctgcg ggggtggcga gtacaggaac
     8641 ctgggtgcgg tccacgatga ccacggtgtc ggagttgacc ttgtcaagca gctcgttcat
     8701 gagtcctcct tctgttctgt tgatcctcag cgcgccgcga cccggtaggc accgtatgcg
     8761 gccccactca cagcgcccgc tcctacggct gctccagccg cccacgcaag ggcggcgggt
     8821 gtggcgagta ccggcgtacc taccctgctg gcccgcagtc gaagcgatcc cttcagtgtg
     8881 ggatccgagt tgaccttgtc aagcagtatc tgcatacgct ctctcctttc tgtcccaagg
     8941 gggacaatct gtccagtgag aacttttctc ctggaggtct agtcgtcagg tgacgatacg
     9001 aagagcagcg ctaccactac tcccgctgtc acggccaata caatcgagga cgccgctcta
     9061 cctggattag ccatatgatc gaacatgagt agataggcga caggacctgc atacattgtt
     9121 gtcagccaga atgcgtacca cctagacatc tgcacctcct aacaagcagg cgaggtgctt
     9181 ggtcctcacg tctttcagag gctgctgaga cgcccggaaa cattgagtga cgcgcatctg
     9241 tccgatctgg gagtcattgc gtggatattg gtgctgattt ctcatggcgt gccccttttc
     9301 agagcgaacc agtcgaaggg tgcgccatgc gtggcgtact ctgcctgcac ggggtcaaac
     9361 cctgcctgcc gtgcgagtga ctcgaactct ccctcgccca gcaccagcac cctctctcgg
     9421 aagagagagt ccgtgccgtc cgggtaatga accctggctt cggtctccat gaggtccccg
     9481 tcccacgatg cctggaactc gcaccacccc tggccgtctg gcaccgggaa gcgcgatggt
     9541 ccggcctcgg agagggcgcg ataggtggac agcgagtagt tctctgcgat cagggttcct
     9601 ccggggacca gcacctctct gacgtgccgc aggcagtccg cgtactcctc aaggctgtcc
     9661 acgtaggaga gtgaccccat cgcagagact gctacctcaa actccccaga atagaagggg
     9721 agcggcagcc tgacgtcagc cagccgggcc aacaggctct ccggcagccg cttggtcagc
     9781 aggtgctcca gcattggctc agagttgtcg ataccggtgt aggaggccgc cacctcagcc
     9841 agcggcagcg ctacccgccc ggtccctata ccgatttcca gggtattgcg tccgcgaacg
     9901 tagggagcgc acctggacac aagctctgtc gggtcactgg cccggctgat gaacggatca
     9961 tacaggtcag ccatgacctg gtcgtactgg ggcgctcctg tcatgaggcc tccaccggct
    10021 cgtagtcgaa caccatgtcg tacagcggat tctccgagtg gtcgtatcct gagtaccgca
    10081 ccaggagcac ctggaagtag gggtatccct cgcgtggtgt gaccctggcg cgcacaaagc
    10141 tggtgaccag cctcttggcc gactccaccg cctccttctc cgtagggaca gaggcggcct
    10201 ggttgttcag gatggtggag gcggcgtcga agatgctctt ctccatacgc cgggccggga
    10261 accagaacgc gtgccaccac cgtctgggct cagcctcgta gactgacatc cacggggtgt
    10321 ggtccgatcg gtcctcgtta gcgaggcggt acaggaagtg ctggtcgtgg actgccgggt
    10381 taggggcgaa gaagcgccag ttggggatga gcaaccccgt gccggtgcgg tccacctggc
    10441 gtacccggtc aaagctgcgg tcagggtgct gggacagggc cgtgaccacc agccacacgg
    10501 caaacactgc cggtagtaag cggcgcagca aggctttcat gaggtgacct cccggggctc
    10561 ggggcgttcc tggaccagtg agacgacctg ctcggccagg cgcggggcag cctgcggggc
    10621 gttgatgatg ctcaggtggt cgcagtcctc caggtccagg cgcctgccgc ccgccgagcc
    10681 tgaggccacg tactcatcgt agagcccgcc ctgctccgag gagcccgcca cggtcgcctc
    10741 cgcagcgatc acatagaccg gggtggctac ctgctccagg ggcgccccgc cgtccagcag
    10801 gtaggggtag aggtagcgcc actcccgggc tgcggcgtac caggtggagg ctgccgatat
    10861 ttctgcgcgc aggcgcccca gggaggggct gccagccgcc gagctcagga caccgccctt
    10921 gtccatcagc aggcccgcgc ccagcgcgac aggaagcggg gcggtgcgca aggtgaggtc
    10981 agttgccttg gccccctctc tctgcggctg gctcaccacc atctcgcgag ggtgcatagg
    11041 gtcgatgagg atgaccccgg caatgttgtc gagctggcca gccagccggt gaaccaggta
    11101 gccgcccatg gagtgcccgg ccagccagat gggatcatcc ccggagcaca cctccttcac
    11161 cacgtcggct gcgtcggcaa cagactcctg gaggtggtag ggggcctctg agcgccacag
    11221 cgagcgcccg tagcccgcgc ggtcgtagag gacaggtgtc atgccagaca ggtgcgaggc
    11281 cagcagcagc cacgaggttg aggtgttcat gagcccgctg gcgaacagca ctgtggccct
    11341 gctgtccccg gcggagtcac cccggtagca ggacagctcg ttgccgctgc ggcagctcac
    11401 cacgtggtgc tcgtagccag agtgacgcct cagcgaacgg gcagtcgcgt acgcctgatg
    11461 tgccaggccg atccccagcg ccgccgccgt cacagtaact gtgtcacgca tcacgctcat
    11521 gcggacacct cctcccggcg caccaggctt cgtaccgcag ggtaggtaga cacgaacgcc
    11581 caggagaacc tcgacagccc catgaaccgg gcattggccg cgtggaaggc cgccatgaca
    11641 gccaggcccc agtccatgta ccggcctctg cccacagcca gcagcgggaa gagggcctca
    11701 aaggccacga caccccggca cagtgcccgc gccgaacgcg ggaaccgcgt cagcagacgg
    11761 tagaagccct cgtcaccata ggtctgggtg cgcatgatgc tgaccagggc gtccccgctc
    11821 ttccacaggg cacccggcat cttggtgata cccgctgcgc tgtaggacag gatggtctgt
    11881 gccccgatga actcgatcgc ggcgcgcctg gtgccagccg tgccaccggc ccgtccgagc
    11941 cctgctgcgg ccgcaaccag gaaggagacc tggtccgacc cgtccgtccc atacaggtgc
    12001 ctggggtaca gcagcagctg agacccggca aggagcagat ccgctccggc acgcaccccc
    12061 tggtgcctca caggcgacag cagcaccagc cccgcgccga cctgcgccac gtgcaggccc
    12121 gaggtcaccg cctcggtagc aacaaggtcg cgcatcctac gggttaactg cagccttgag
    12181 ggcacctggt ccctggcgag actccagtcg ttgagcccgc ccttggctcg gtcagcccgt
    12241 cggacaaggt actcggcgct ggacagcagc tggcacacgg ccgacacccg ctcagcagta
    12301 cccagaggcg cccccaacgc cctcgacagc acgctgtcga caacagggcg aggtgcaggc
    12361 acacgctctc gcgatctcct cagactcttc attgaacccc tccgaaagtc atgcagaaac
    12421 ttggcacagc agccagcggc agagcctgct gacctgctga gtagcgtgtg ccgtgctcgg
    12481 cgttgaacca gcgttttctt cgataagaaa tgtagatgag gaaggttgtc ggctgctcct
    12541 accagaggcc ggaggctgtc ctgctgtggg aggaggttcg tggggccttt cctccttctg
    12601 gcggagagcc tggaaccgtg cgctgccggg gctggtcgag ctctgggtgc tctccgttgc
    12661 ggacgagggc agagggggtg tggtgcgccg ccgggctggg cgaggtcggt gtgctccgac
    12721 cgccacagga gcacagggcg gcgggcgtta tgatcactca gcggtctgcg cgcaggtccg
    12781 tgaagccgct gccctgcccg cctgtcctgg ctggggtctt gcctgcacgg atcgcccggg
    12841 ctccggggga cggacagaag cacgggcgcg atccggatcc cacggctgcg agccgaactc
    12901 ctgactgaaa ggaacgtact catggccacc gaccagcaga agacggtgat cgtggttgac
    12961 cggcacctcc cggtgggcct ggctgtcaac gctgcctcca tcgtctccgc gatggtcgcc
    13021 agcgcctgcc cgcagatcat ggggccatcg gtgaggacgg ctgactccga gctgccgggc
    13081 gtcgtcctca ccccgctgcc cgttcttgct ggtgacagcg ggctgctcgc ctcggtgtgg
    13141 agccgtgccg aggcgcaggg ctccggcgtt gatgtctttc ccttcacccg cctggcgcag
    13201 gggtgcagga cttatgaaga gtatgtctcc aggctcggtt ctgccctcac acgtgacctg
    13261 gagctggcgg cacacgtgac ctggagctgg cggcacacgt gacctggagc tggctgtgat
    13321 cggtctccag gccccaggag gtccgtcacc tccctgaccg gtgacctgcc gctgcacccc
    13381 acgaaggacg cgtaggagac aaggggggca ggacaacgct gcttcttccc agaagcaggc
    13441 ttgtcgatca catgacctgc atagcacgcc agacctatga ctgccgtgcg gctgtgtcaa
    13501 ggaactaacc tgcaccagtt acagccatgc ccattgcatt ctgatacctc gctcaatcga
    13561 tagacggggc aatccaacca aatgcctcta gttgtaggtg catcggcgac cagtggacat
    13621 tgagagtaca actatttatg gttccatacc agagtcgact ttgctgacac aaaaaagtac
    13681 caacaaatta tgatcctgtt atcaggagac gtccagtaaa ggggctgacc tgcggcgatg
    13741 aggtagtgcg gtgctgttca gggtcgccta ttgtgccaac aaagtagggt caatgctagc
    13801 cacctcttga caagaactcc cacataaggc taacataaat gcagcagggg aggcgcagcc
    13861 taaactatgc tgacccaaca actaaggagg aacgtgtatg tccgatctag ggatcgctcc
    13921 aactgtcgag cagttggaaa aggtggcgaa tcgggagttt agtggaatca gtgaggggtt
    13981 cgtcaactcg cacaatctcc ccacgatgac aactcccgtg acaccggcaa cgcccggcgc
    14041 acttgaggtg gttgtgactg ggagcaccat ctgccttggc tgctaaacat ggatggctag
    14101 cctcgggggc ggatagcctt agggccatag ttagacctag cggaagcagg tccgactatg
    14161 tgcattcctc gctcgcgata gtcgcagcgg agaaggtcat atccgcctcc gaggccttgg
    14221 ccgatattaa agcgtacgac cggggtgaga tactggaagg aataagcttc catcggggaa
    14281 gcagatggct gccgacccgc gcacgaaaag caattgactc taaggcaggg gctgctgcgc
    14341 ttcagttagc aacactggtt ggttctgcgc ttgccctcag ttcccgtagg tcgcggaagt
    14401 gtcaagttgt gggggcgggc gtactcgcat taaccagcgt gatcgaaagt tacaggtgcc
    14461 cctatggcaa cgacggggca gaccagatgt ccgccgtaat atgcggctac agggctgtta
    14521 ctggcctcat accagatcac agcctgtccg atgacatcta cctcagggct gttaacgcgc
    14581 aaacatttct ggcctacttg actcctggct tagcgaagtt aatttcgagt tcctggcttt
    14641 ctggcaccgc tcttcagagg gtccttgaaa caagtcagta cggatcaagt gcaattgcgg
    14701 tgcaactacg gcgttaccct ggcctatcaa aggcgctaac atggatcact attgtatggg
    14761 aaacggcatt tccattggtt tatttgttgc ctgcacgcct ggtgaaccct gccctaggag
    14821 ccgtgaagtt gtttcacgca ggggttgcgc tcactatgga cctacctagg ttcttctggt
    14881 cctttagtgc ggctcattca gcggttctgt atataactga ctctagagtt agtcgtcccg
    14941 ctatcggagg tgggttgtta tcatgagcgg ctttgagcgt ggcctagttg cgagtgcttg
    15001 cagtgtaatt ggggctagcc aggctgtgca actgtcacag tactcgctag agcgtacgcg
    15061 gcgtaacggt ctcaacgggc cttcacttgc tcgtatggat gacggcagtg tagtcgagtt
    15121 catttatgag aatgcgcagg atagtgatca tgtggttatt tttgaaaacg gtcttggtga
    15181 atgtctagaa gcatgggact gggtatgtca cgtattaggt gacaagtacg gtacattgcg
    15241 ctatcaccgt gcaggatacg gtcgcacaac agcgacaata tcggcgccga aaattctcga
    15301 gcaactgtac agtaattatt gtgctgggaa gtccgttacg attgtagcgc attctatcgg
    15361 ggcatttttt ttcgcgcagc acatggccta cgggggtgag gtatcgcatg cagtgaagaa
    15421 ggttgtgctg atagacacga ctaagtttga cacttttctc actgaacgca acgatctggt
    15481 ccggtcggga aggtttcttc agtccttagt gcagacaggc gtgtcaaccg ttgccggaac
    15541 acatgcatgg tccacgaacc aggtggaccg cgaacttgat tatcggccgg atatacgtcg
    15601 cgcagttttt cttttttctc gcagcctttc gacgttaaga aattcctggc gagagtatcg
    15661 ttccacagtt gttcctgatc ttcggactat tgccgcccct gaatgtcatg tgctggcggc
    15721 cgaggacaac gttgatgaac agaaaggagt tgcgaatgac ttgggggcca gattcgacgt
    15781 tgttgcagga tctgctcatc attctattat aggaaagtta gagtgcgttg aagaggtttg
    15841 tagaattgta tgggggtagg catcgtatgc gtaactacgc attagtgcga tggttactat
    15901 atgggcatat tgtccttacg ctgttggaca atttgccctc ctccactctt tctgtggtat
    15961 ccaagacgcc attcctccct caacctcctc aatggaagtt ctttgccccc aacccagggg
    16021 ttgaaaatta ttatgtcttc tatcgcttta gaagcaagga agacgccgaa tctgcaggtg
    16081 ctggcgcatg gcgggtattt cccatgacgc gtcagtcgaa atggtacagt tttttgtgga
    16141 actctggaag ccgccgggga aaggctttat ttgatgtggt ccaacaggta cggatcctcg
    16201 caggacactc aggatcctat gagtgggcca agcgaagcca ggcctttata attctggaga
    16261 aaataataga aaagcacatt ggggctatta ggaagagcga acgtcccgaa gaagcgggcc
    16321 gtgaagggcc atctcattac cagttcatga taatggggtc cctgccggcc gccggagagg
    16381 atggtttcaa gcctatcgca gtctcaccat ggatcgagat ttcatgacgt ttgaatttcg
    16441 tgtcgtgtcc gatgtaggga cattgagttc ctacatgggg aacgcgcctt ctgtgcgagc
    16501 aagttcccta cacctttgga ttactggttc catatccgct agtctcgtac catactggat
    16561 gcgttggatc atcgagacct atcacggtat tcacatttca gcaactgtct ctcatgctgc
    16621 tactcgtttc gtagcacctg aagcagtaca tcagattgca cgtgatactg gagggtgggc
    16681 tgctctagac gattgggatg agtctggtcc tacggggcgg ctctcacatg ctgatatcgc
    16741 catggccgct gaagcgttcc tggtctttcc tggaaccgtt aattcggtga tgtccctggc
    16801 ttgcggatta tcgtctacgc cgtcaatgct ggcgttgcag gttagtgaaa aaccactggt
    16861 gattgctgcc tcgtttccat gcatgaatac tgtcttgtca agtgggttag aaaagttgaa
    16921 tgagcgggct aacgtggctt tttctcctct tgtccttgct aagggtgttt catccggaaa
    16981 gtggtcggag ttgagcggac tttttgctcc gctcgttatg gcggaactgg gtactctaga
    17041 ggaagagttg tatgatgggc gcagatcgga gtgatggcac agtgcggtgc ggtagccttt
    17101 cgtggccagc gcagcatagt ttatatttgc cgtatggttt gtagtttatg atgtctgctg
    17161 ctgagcatgt tgttactagc ctagttcgtc cagttgcact gaggccggga gtggaatata
    17221 ttcatacatc cgggctgtca gtaggctttg agggtcaccc agtatgttcg tcagtcgact
    17281 tgaaagttgg tcccggagaa gctctatttg tcgttggagc caatggtgct ggcaagtcca
    17341 ctcttctgcg aacctgcctc ggtctgcagc ctgccatctc cggtagttcg ctcgtcatgg
    17401 gtgaagtcgc tgatccacgg tcatcacttc agcgttcctg tgtcgcacgc gatttaggcg
    17461 atgaggcgtt tttcccatcg ttgagtgtac gtgagcactt ggaattagtc agttatgggc
    17521 atggtgtgaa gaatgctaga agcattgttg agtcggtgat ggaggaaatg gggttgttgg
    17581 ctgtggcgga ttccgtccca gacaggctat cttctggtca gcgccgtcgg ctttccctat
    17641 cgagtgttct tgttcgcccg cggagtatac tggtcctgga cgagcctgag caacgtcttg
    17701 atgcggctac tcgtaaggcg cttgccggtt atctgaatgc tgagcgtgag gcgggggggg
    17761 cactgcttgt cgtgtcacat gaccctgttt tagttgaggc gagcgctagc gcggtgcttg
    17821 tggtgggctc ggagacgatg atttatgacg tgggtgccgg tgtgcttgct ctgaaggaag
    17881 gcacatgagt tctgttccgg acctttacca gttgcgcgcg tggacacgtg ttcgcgttac
    17941 agaacgtcga cgaagtagtt tgacgaagac tgatggattc tctgacatct acgtgttgat
    18001 gctgggtgtc ggtgtatggg cacccatgct ttttcatttt tttgcacgtt ctgatgtgcg
    18061 gctttcccct gtatacgttg atactttcac gggtattact cggtttagtc cgatgtggtt
    18121 tggtaccggt acggctttgc taggtgctgc tgcgtgcgtt ggggcgctac gaaggctcgg
    18181 cccccttttt cttcgcgtcg aagagacgat atggtggttg tcctgtcctg gagatcgggg
    18241 ccaccttatg cggctgcttg cacggcgtat cgttgcgggt ggggcgctgg taggtgcagt
    18301 tgctgctgct gcgcttgtgt ggctgctggg cggagatgct tttggagtgg ctggcgcggc
    18361 gggatctgct gcgtcgatga ttgcatgtgg ccttgtactt actgttcgta gccaggttat
    18421 taaccggggc gcgggtgttt tgcggctatt ttttttaatg gtagcaacta tagctatctg
    18481 catctctggt atttttgttg attcatctcc atacagaatg tggatcgtgg gttgctctgt
    18541 gctggcgacg gtggctggta cgtatgcggc ttggttggtg acggctccga gtttgggcag
    18601 cgtgcctgac gttatcctct ccgagtctgc gcagcgtggt gctagtcttc gggctgtggg
    18661 cttagctctg gacacgcgcg ggctggggtt cgttcttgca ccgccagttc ggcgaccgtt
    18721 acgccctgac agcctcgctg ttgttcggtg ggctctactt ggcgaggggc tgtttcgctg
    18781 gattttcact ggatcacgtt ctcgtagcgt gttgggcgtg gtgcaggcag atcttctttt
    18841 gctgcgacgt caaccgtgga gaaccgtgac ggcgttgtgt cttgcggtca ttgcgggcct
    18901 gcttctgttg tttgatgcct atggatttgg gctcgcgatg ctccttgttt ttgcgtggtt
    18961 agttagtctc atctgcgctg atgcggcgcg gcgtgcgcag cgtgacgacg caccggatag
    19021 cctatggcct gcggctcctg tatgggtccg tttgggacac tttattattc cggctttatt
    19081 catgattttc tggtggtgtg ctgttgattt ggtagtcgtt tttggaagtg ctattatgaa
    19141 tgacgatgtc cccggagagt tgctggtagc gggttttttg tccgggccgg gttgggcggg
    19201 tgtgtcactg cgttctggtt ttcgacgtga ctctgactgg tcgatgtcag ttcctacgcc
    19261 tgttggcttg attccgattg ggttattaca gtctgtcacc gtgggtccgg atgctgccgt
    19321 ggttctggtt ataccggttc ttattgctga caccctgtcg gtctctatga gtctgtgtct
    19381 tgcccagctc ggcctcagtt tcttagttgt tatattggga tttttgaccg gacgtgacaa
    19441 tatgcgatga gttacagctt ctcgtcgttg gatcgtggat cctggttggt tgcgggattt
    19501 ctgttcgctg cgacctagac gtatgcggcg tgcatggtga ttgcttctga cgccgtgcga
    19561 tgatcggtta tatctgttag ggctttggtt gacgcttggt gtgggtgctt ggatcgtttc
    19621 acattacgtt tcggaaagat gggtgctggg aacttctatc acactcgaac atccggtccg
    19681 gtgggcctgg gcggattgct atgcacgcct ggcgcagggg tgcaggactt atgaagagta
    19741 tgtctccagg ctcggttctg ccctcacacg tgacctggag ctggcggcgc tggggctccg
    19801 aggacccagg aggcaggtca cctccctgac gggtgacctg ccgctgtacc ccgcgaagga
    19861 cgcgtgacat agcggcaggt gcaggagggg ctgtctcagg caggcgcgct caggcaggcg
    19921 cggcgggcga gtggttgcgc tgctcctggg cggtactgtt ggcagtgggg gtggctggga
    19981 cgcagccccg gcgggcacgt cggtagcgcg ccacgatgat ggcggccagc acacacacgg
    20041 ctgccaccgc caccacgcgg cccgcagggc tggtgtacca ggcggccagg accgccatgc
    20101 cgatcgtggt gtagaccccc gcccaggcca gtgcccctac tgccgtggcc agggcgtagc
    20161 ggtgcagtgg catgcgggtc actcctgcgg acagttggat ggcgctctgg aggcccaccg
    20221 tgaggaagga cagggggacg gccagcacac cccaccgtgc tgaccaggcc tgggcgcgtg
    20281 cgtacaccgg ggactccagc accctggccc aacgggtgcg ggccgtgccc gccgtgacgc
    20341 cccgccccat ccagtacatg gtgtgggacc gcatcatggc caggcaccag aagaacagaa
    20401 agactcccgg gtagggcagc tcgtggatcc ggtccatcac gtaggccagc ctaacttagg
    20461 cggggcaggg caacgtaatc gtcataggac aacacggcac cgtgttgtcc tatgacgatt
    20521 tggtgccgtg agccgggcgg ggcgggcccg gtgccgtgag cggggcctgg gcgcagaaca
    20581 ggtcctggaa tcgacaggtt ggtcctgcgg gctggctctg ccgcagggga accggcttga
    20641 ctgtgcccag gcctccctga cggtgaccaa cggtgccagg cgcccgcctg cgctcccgtc
    20701 ccaccagcgg cggctccgtg ctcctgccca ctcagcctcg tgcacggacc acgcgtcagc
    20761 ggggcacaca gccacagaca cagaggtaca gaagaggtac agagaggtac tcggccatgc
    20821 tgtcgatcaa ctggaacgac gtctggaacg tcgtggcaag cctgcgacca cagcttatcg
    20881 ccattggcgt cgtgctcctg ctggccgtgg tcgtcacggt tgccgtaaga cgcagggaca
    20941 ggcccgtgcg caagctggtg cgctctacca cgtgggtcgc ggccgcgctc gccgtggcgg
    21001 tggccgtcac ctccatgatg tacggcggcc tgcgcaccat cctggacctg tcctccggtg
    21061 cgggcacgct cagcgaggag accagtgcca ccgtcgagga gctggggaac accatctccg
    21121 aggagggcat ggtgctgctg aagaacaccg acggcgccct gccgctggag gagggctccg
    21181 cgctcaacgt gctcggctgg gcctcgacca acccgatcta cggcgggacc ggctcgggct
    21241 cgctcagccc ggacaacccc acgaccacgc tcctggacgg cctgcacaac gcggggttca
    21301 ccaccaacga ggagctcacc tccctgtaca ccggctaccg cgccgagcgc cccgaggttg
    21361 gcatgttcga ggctgactgg accctgccag agcccacctc gcaggcctac acctcagacg
    21421 tcgtcaccgg ccttgaggag ttctccgaca cctctgtggt cactatcgcc cgctccggcg
    21481 gggagggctt tgacctgccc caggacgtca acgccgaggt cgccgacaac cctgccttca
    21541 gctacaccga caacgccgag gacacccccg acttcgccga cgggcagggc tacctggagc
    21601 tgaccgcccc cgagcgcgac ctcatcgagc tggccaagac cagctcacag accaccgtcg
    21661 tggtcatcaa ctcggccaac gccatggagc tgggcgagct ggaggccgac cccgacatcg
    21721 acgccatcat ctgggccgtc cccggaggcc aggtaggctt caacgccctg gggcgcatcc
    21781 tggacggcga ggtcaacccc tccgcccgga cccccgacac cttcgtcacc gacatcacgt
    21841 cctctcccgc agccaacaac ttcggggact tcacctacac caacatggag ggctacggcc
    21901 agacctcccc gttcaccgac accacgacct acccggggtt cgtcagctac gtggagggga
    21961 tctacgtcgg ctaccgctgg tacgagaccg ctgcggccga gggggtcatc gactacgaca
    22021 aggaggtcgt ctaccccttc ggctacgggc tgtcctacac caccttccgc caggagatgg
    22081 gggaggtgac ctacgctgac gggaccgtct ccttcgacgt cacggtcacc aacaccggtg
    22141 acgtggcggg caaggacgtc gtggaggcct actacaccgc cccctacacc gacggcggca
    22201 ttgagaagtc ggccgtcgac ctggccgact acgccaagac cggcctgctg gagcccggcg
    22261 cctccgagac ggtgaccatc agctttgacg acgacgacat ggcctcctac gactcccagg
    22321 acgccaaggc ctgggtgctg gaggccggcg actacaccgt gtccatccgc agcgactccc
    22381 acacggtcat cgactcggcc gaggtcacgg tccccggcac cgtcacctac accggtgaga
    22441 ccacccacga cggggacgcc gtggcggcca ccaaccagtt cgacgacgcc gcaggtgacg
    22501 tcacctacct gtctcgtgcc gactccttcg ccaactacga ggaggctacc gccgccccct
    22561 cctcgctgga gatgtcgcag gagcaccggg agtccttcgt ggccaacgac acctacgacg
    22621 cctcccagga ggacgacccc gacgccgaga tgccgaccac gggggcggac aacgggctcg
    22681 tcctgggcga catgcacggc ctggactacg acgacccgca gtgggaccgg ctgctcgacc
    22741 agctgagcgt ggaggagatg aacgacctca tcgcccacgg cggctacggg tcggtggccg
    22801 tcgactcggt gggcaaggtc cgcgtctccg acgtggacgg ccccgcctcc ctcaacaaca
    22861 acttcaccgg ggtgggctcc atcggcctgg ccaccgccgt gtccgtggcg gccacctgga
    22921 acaaggagat cgcccacgac ttcggcaccg ccatcggcac catggcgcac gacatggacg
    22981 tggcaggctg gtacgccccg gccaccaaca cccaccgcta cgcctacgcc gggcgcaact
    23041 tcgagtactt ctccgaggac ccggtcctgg caggcaacca ggtggcccag gagatccagg
    23101 gggccaagga gctgggcgtc tacgccttcg tcaagcactt cgccttcaac gaccaggaga
    23161 ccaaccgcac caacatgctc gtcacctggt cccaggagca ggcgctgcgt gagatctacc
    23221 tgcgctcctt cgagatcggc atcaaggagg gtggcgccgg ggcggtcatg accgcgttca
    23281 actacatcgg gaccacctac gcgggcgcct ctcccgccct ccagcaggcc gtcctgcggg
    23341 atgagtgggg cttccgcggc atgacgctca ccgactactt cgcgggctac ggctaccaga
    23401 acgccgacca gctggtgcgc aacggtggtg acatgatgct ggcgaccacc gacatcgggg
    23461 tgaacttcgt ccagcacacc tcggccgcag gcgtccaggc gatgcgcacc gcctcgcaca
    23521 acatcctcta caccgtggcc agctcgtggg tctatgagga cggccagccc gagacgcagc
    23581 gtgcgtcctg ggagtacgtg acctgggccg tgctcggggt gctgggtgtg gtcctcctgg
    23641 gcctggaggc cctggctgtg cggcgcttcc tggcccgcag gaggcaggcg gcggcccagg
    23701 cggccgacgg cgctgccgcg cagccctccg gctcctcagg gtctgcgggc tccgctgagt
    23761 aggcgctgct cgccccaggc agcaggaggt gggcgggcgc gcccgtgccc gcccacactc
    23821 ccggccggcg gactgtcccg gccgctggca cccgtcctgt gccccccttc ttctaccgtt
    23881 gcaaactgcc actggaacga cctgagaaag gacgcctcgt gacccccgac ccccgcgacc
    23941 tcaccctgct ggaggccgcc gccctgctct cgggcgcctc cgagtggcag tcccgggcac
    24001 tgcccgccag gggcgtgcgc tccttcgtcc tgtccgacgg ccctcacggg gtgcgccgcc
    24061 agctcggcag cggcgaccac ctgggtatcg ccgcctcaca gcccgccacc tgctttccca
    24121 cagccgccac cgtggccaac agctgggacc ccgagctggc tgaggagatg ggggcggccc
    24181 tggggcagga ggcccgtgcg ctgggggttg acgtcctctt gggaccgggg ctcaacatca
    24241 agcgctcacc gctgtgcggg cgcagcttcg agtactactc cgaggacccg ctgctgtcgg
    24301 gccgcatggc ggccggggtg gtgcgcggca tccagtccca gggggttgcc gccaccccca
    24361 agcacttcgc tgtcaacagc caggagctgc gccgcatggc ctcggactcg gtggtcgatg
    24421 agcgcaccat gcgcgagctc tacctcaccg ccttcgagat cgttgtgcgt gaggcggcgc
    24481 cgcgcgccct catgagcgcc tacaacaagg tcaacggcgt ctacgccaat gagaaccacc
    24541 acctgctcac cgagatcctg cggcaggagt ggggctttga cggcatggtc gtctccgact
    24601 ggggaggctc taactgcgca cccgctgcgg cgggggcagg aagctccctg gagatgcccg
    24661 cccccgggct gcactcggca cgggaggttg tcgccgcggt ggagtccggg gagctctccc
    24721 acgagcaggt ccaggcccgc gccgccgagg tcctggccct ggcggaggcg gcctcctccc
    24781 acgggcagcg cccgggcctg ggggcgcggg agcaccacca cctggctcgg cgcgtggccg
    24841 aggagtccat cgtgctgctg cgcaacgagg acgcgatcct ccccctggcc ccggggacca
    24901 gggtggccgt catcggtgac atggcccgca cgccgcgcta ccagggtgct ggctcctccc
    24961 aggtcaaccc cgtccgcctg gagaacctcc tggaggccgt cggggagacc gagctggagc
    25021 tcgtcggcta cgcccagggg taccagcgtg acggcacccc ggacccggtc ctgtcccgcc
    25081 gggcggccgt cctggccgcc agggccgagg tggccctggt gtgcctcggc ctggacgagc
    25141 tcagcgagtc cgagggcctg gaccgcagcc acatgcgcct gccccaggcg cagacccgtg
    25201 tgctggccga ggtggcccgg gccaacccgc gcacggtcgc cgtcgtgtcg gccgggtccg
    25261 ccgtggagac gcactgggag gcccacgccc gcgccgtcgt ccacacctac ctgtccgggc
    25321 aggccggggc gtcggcgacg ctgcgggtgc tcaccggggc ggtcaacccc tccggccgcc
    25381 tggccgagac ctacccggtg cgctacgagg accacccagt cgccgcctgg ttccccgcca
    25441 ccggggagca cgcgctgtac cgggagggac cctacgtcgg ctaccgatac ttcaccacca
    25501 ccgggacccc ggtggcccac cccttcggct tcggcctgtc ctactcctcc ttcgactact
    25561 ccgacctcga ggttgacgcg cagggggcac ggttcaccct gaccaacacc tcccaggttg
    25621 acggcgctga ggtggcccag ctctacgtgc gcccgcccgg cggcctgtgg gggccgagca
    25681 tccagctcaa gggcttcgcc aaggtgtggc tggaggccgg gcagtcgtgc aaggtgcgcg
    25741 ttcctttcga ccgctacacc ttccgccact acgacgtggg ggagcaggcc tggtgcgtgg
    25801 agggagggac ctggaccgtg gaagtgggac gcaacgtcga ggacctgcct ctccgggcgg
    25861 agctggaggt ggaggggacc cgcccgcagc ccgcatgcca ggagctgggt ccctacctca
    25921 ccggcgaggt cacccaggtc agcgacgccc agttccgggc cctcctgggg cgcccgctgc
    25981 ctgtggcccg cacaggccgg gaggtgggcg tcaacgaccc ggtgtcgtcc ctggcccagg
    26041 cgcgcagcct cctggcgcgc gcggccgtca gggtgctcac ctggaggagg gccagggccg
    26101 aggccagggg cagacccgac ctcaacatcc tcttcctcct caacatgccg ttgagggcca
    26161 tggccaagat gacctcgggc atggtcgatg gggagatggt ggagggcgtc gtcgacatcg
    26221 ccaacgggca ccccctgcgg ggggtgcggc gcaccgccgt gggctacctg cgcaaccggc
    26281 gcgcggaccg ggtcacccgg cgtgagctgt ccgggtgcta ggccgcccgg gaacctagcc
    26341 tcctgggcgc cgccaggcag cagcaggcag accaccacac agacaacgta gacactgcaa
    26401 agtagaccct gcaaacagtg caaggag
//
