LOCUS       NZ_CP025227            22670 bp    DNA     circular CON 14-APR-2024
DEFINITION  Actinomyces wuliandei strain 299 chromosome, complete genome.
ACCESSION   NZ_CP025227
VERSION     NZ_CP025227.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces wuliandei
  ORGANISM  Actinomyces wuliandei
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3107761)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2017) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, No.155 ChangBai Road, Changping District, beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004010955.1-RS_2024_04_14
            Annotation Date                   :: 04/14/2024 19:14:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,606
            CDSs (total)                      :: 2,544
            Genes (coding)                    :: 2,496
            CDSs (with protein)               :: 2,496
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 18 of 48
            Pseudo Genes (incomplete)         :: 37 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 9 of 48
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 986438
            Orig. end                         :: 1009108
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025227.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22670
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="5"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22670
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22670
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12670](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12670)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(121..135)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.57"
                     /tool="antismash"
     gene            complement(552..1235)
                     /locus_tag="CWS50_RS04065"
     CDS             complement(552..1235)
                     /NRPS_PKS="Domain: AMP-binding (39-194). E-value: 3.2e-09.
                     Score: 27.8. Matches aSDomain:
                     nrpspksdomains_CWS50_RS04065_AMP-binding.1"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="phenylacetate--CoA ligase family protein"
                     /protein_id="WP_127841761.1"
                     /transl_table=11
                     /translation="MMGPTELHSTGDTFGDVFRSLGHSSIKMWPHSPVVGFDRASHLLQ
                     RLPITGLTCTPGMTILLARHLLASGVDPSALGIRVILTVGEMATPQLLKQIGQLWDADI
                     YSCMYASQEASILAVCQSDGRLRTTPLNYYYEIIEPNTGMVLNPKSDEREGELVITHLY
                     RGAKPLIRYRTGDLVRTRGAGQDFTITPIGRVLDELHIGNTIYAAYDFEAVVLQDCPNF
                     LDYQV"
     aSDomain        complement(654..1118)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CWS50_RS04065_AMP-binding.1"
                     /evalue="3.20E-09"
                     /label="CWS50_RS04065_AMP-binding.1"
                     /locus_tag="CWS50_RS04065"
                     /protein_end="194"
                     /protein_start="39"
                     /score="27.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ASHLLQRLPITGLTCTPGMTILLARHLLASGVDPSALGIRVILTV
                     GEMATPQLLKQIGQLWDADIYSCMYASQEASILAVCQSDGRLRTTPLNYYYEIIEPNTG
                     MVLNPKSDEREGELVITHLYRGAKPLIRYRTGDLVRTRGAGQDFTITPIGR"
     misc_feature    1231..1245
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.07"
                     /tool="antismash"
     gene            complement(1665..2105)
                     /locus_tag="CWS50_RS13415"
     CDS             complement(1665..2105)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF020947.4"
                     /locus_tag="CWS50_RS13415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2000 domain-containing protein"
                     /protein_id="WP_139738299.1"
                     /transl_table=11
                     /translation="MNTEHQKRGHKTVIVVDRHLPTGLAVNAASIVAAMIAVKFPELMG
                     PPAKTADSELPGVILAPLPVLAGSAKLLTSAWSHADQDDSGIDAFPFTRLAQGCKTYDE
                     YIAKLGSTISRDLELAAIGLCGPKKAINSLTGDLPLYPVKEK"
     misc_feature    complement(1926..1928)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2102..2479)
                     /locus_tag="CWS50_RS13420"
     CDS             complement(2102..2479)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0005215 - transporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013088.4"
                     /locus_tag="CWS50_RS13420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DMT family transporter"
                     /protein_id="WP_341472744.1"
                     /transl_table=11
                     /translation="MSGGGIGFCLLIHLLPEGTTINLSSPAIWLIVYLAVGCSALAFLL
                     YTFGLTVLKPSQAVAILNLVPVFGVVWAVVIAGEEVTILKLVGAITVIIGVVMSSRSTL
                     PPSRKQRTLDSIPQFQKESRL"
     misc_feature    complement(2105..2107)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(2222..2224)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2442..2455
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.9"
                     /tool="antismash"
     gene            complement(3062..3385)
                     /locus_tag="CWS50_RS04075"
     CDS             complement(3062..3385)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019491.4"
                     /locus_tag="CWS50_RS04075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Dabb family protein"
                     /protein_id="WP_164860072.1"
                     /transl_table=11
                     /translation="MNGTHLIHVVAFTLKPGISREDPRVQAAATITGGHPATIPEIATW
                     ACGWDTSRRPDSADFLVVGTFDTAVDYDTFQTHPDHQRGKEAWKQIATWSVADILAVNS
                     EQP"
     gene            3928..4329
                     /locus_tag="CWS50_RS04080"
     CDS             3928..4329
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_243118450.1"
                     /transl_table=11
                     /translation="MRAVVWTASAKAAPVLADNLVAVLTAAPGQEPLLESYAHENLGTV
                     ASLGIGKGVARILGHSLRGFVAWTAHRGYHVYAVPTLNRKVRIMMDWFAAVVFRRDLAS
                     FGSVAAPGVAFARATANDARIASRHHQPG"
     gene            complement(4403..6904)
                     /locus_tag="CWS50_RS04085"
     CDS             complement(4403..6904)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="CWS50_RS04085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_127841763.1"
                     /transl_table=11
                     /translation="MNQVLLSSVRAHVGRLIATGLAVTLSVAFVVTTLLLSSSYRQTMV
                     DGLTAQMDQADLQVAVTDNDAETADIDEQVATALEGLHRLEEVAAADAQRSSYVQVAFG
                     ARRANASVEPLLSPQNRWQELSSGDWPSAPGEVAIDDGNAEALGVTVGDTLRVTNAVGH
                     GGSSDLTVVGLTSAANAGFSQGTPVLITTEATFEALGPSAVTTGILVSASEGVSPGALS
                     ARVAEHVVVGSSLSVLTREEAVEHQLAELSGSSTLLTNMMLVFGAVSLLVSGFVIANTF
                     RVLVAQRTAELALLRCIGAGVAQVYRLILLEAGIVGLVFSAAGAAIGTGVAAALVSASA
                     SGGTGLPLSAFSIPPLMVAGATACGTVVTTVSALGPARNATKVRPIAALRPLEAVSTRR
                     VPVAAAVIGPGLTVLGAVAMVHAAGRGSIAVAVAGGLVASLGVLVVSSVLLPLTVRLLG
                     MLISPVSAPTQLAAANVNRNRRRTAATGAALLIGSILLAMLTTGVSSARESVVAQIDDR
                     RPIDLIAETAPGQAIDTETIAAITNVPDVVASAEILTGAVDLESASTTVQQAVAEGVDQ
                     QATSSVARSEVSVPQAGSVHVSPDDPAARYGGQHITARGADGETTLVVVVDEDVPEGIV
                     QVASSELVDIDSSPDVTRLQLRLEDGMSPTDIQSVMTDISALDEDINVSGGAQERAYYN
                     QILDTMLMVVLALLAVAVVIAFVGIGNTAALSVVERRRESALLRTVGLGRGQLMAMICT
                     EAGLTAIVSTALGLVAGVLLGWAGVTTLGQSASEVEMTLHVPWGQLAAILAGAAVAGTL
                     AALLPAYAASRRRPVEDLAAA"
     misc_feature    complement(5549..5551)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6901..7656)
                     /locus_tag="CWS50_RS04090"
     CDS             complement(6901..7656)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005507396.1"
                     /locus_tag="CWS50_RS04090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_127841764.1"
                     /transl_table=11
                     /translation="MQSSKAAVRAVNLRKTYGSGEAAVTALGGVDLEVAQGSFLAVMGP
                     SGSGKSTLMQTMAGLDSLDAGEVWIEGTNITRLRDRQLTRMRRDRIGFIFQSFNLVPTL
                     TAEQNILLPLKIARKKQDKEWVSLVVKELGIGDRLSHRPHELSGGQQQRVAIARAVMTQ
                     PAVVFADEPTGNLDSSSGTRILYLLRDMVSELGQTVIMVTHDPKAASYADEVLILADGK
                     ARETIQEPTQRAVLEALSRLESDDEEPTS"
     misc_feature    complement(7576..7578)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7802..8803)
                     /locus_tag="CWS50_RS04095"
     CDS             complement(7802..8803)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CWS50_RS04095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_243118507.1"
                     /transl_table=11
                     /translation="MTAGASGAVDAALIVSVQALAGFLLGQVSQVTGSFSQVAQGWTLL
                     ERVTDILIRPEDSTFRGHETPAPGAAVVVDNVTFSYDSFTNPVLSDVTLSIPSGATVAL
                     VGRSGSGKSTLGRLIVGLHEPSVGRTEIDGRAVSEFDRHQFYANVAYVPQNVVLDTGTL
                     RDNLIMGAGKVTDTDIMEAARNVGFEDDICSLPLGLDTPVAQMGQNFSGGQRQRIALTR
                     AALKKARIVVLDEATSSLDNTAEARVTKFFSGLSATRVVIAHRLSTVIDADIIFVIDNG
                     KVVERGRHQELIERGGAYSELYLRSRSEDSLWDGSRPDDGAGSDPSTARPGG"
     misc_feature    complement(8315..8317)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8672..8674)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(8775..10004)
                     /locus_tag="CWS50_RS04100"
     CDS             complement(8775..10004)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="CWS50_RS04100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_127841766.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-24, bitscore:
                     82.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVRARRRPKLVRQLNQTECALCCCAILLRSQGSSVTMNDLRLR
                     YTVGRDGLNIAHIAEILRQEGATPHVFAVTADEVIGLREPAICHWNSNHYVVVDPRNNV
                     RIRIVDPGAGVIRLGFQEFSDKFGGYAITIDPHPEPVRRNVPTAFSVLWRLARSHVLLL
                     LITLAVALGSALATLWLPQLLSATFSMDIAGSSSLLWPLSVLAGIALGYALLTLTRSIV
                     SLIAATAVGKSMSQTVFSRMMRLPYGDLAHRGVGDLLFTLDSVQRLRMLITTDFIVVVV
                     GAIMVTTLIIWLTVVSPLAGIVAVGLIVLLVVLALASGRGVRRFSLEETRRRAELQSIQ
                     VSAVSGLESIRTNAMEDAYIQRWRTSNNSVQRYSVGLQSIQGVFTALSASMQLVDPHRL
                     DRDCRCVRCC"
     misc_feature    complement(9108..9110)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9219..9221)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9411..9413)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9651..9653)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9759..9761)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9873..9875)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9915..9917)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(10001..12670)
                     /locus_tag="CWS50_RS04105"
     CDS             complement(10001..12670)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="CWS50_RS04105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_164860074.1"
                     /sec_met_domain="DUF4135 (E-value: 1.5e-67, bitscore:
                     225.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.3e-20, bitscore:
                     69.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTYYEPERVRDLFPELPDIEAVNLLLAEVSSMDPAMVPSPAHNVL
                     KLSSVAPVRPTESSQEYLGFDGFARRVCHADRVVLQKIFEGAEVSIKHALDLAESAWLV
                     LVDRVQQVSSRTLIAAMHVLRDNGQLQGNSSEERYEYFCRLSASEEFERGLLRVFPELS
                     NQISYLRAEAAKTLRTFLVRLERIKKDDQFQAIVGSNPALLSLTSAGSDPHAGGQSVLI
                     AEFENNNNRIVYKPRQMGAELGFGRLVERFNQSAATNLPTLRIIDSDDHGWQEYANMKD
                     GGCADEYFRKCGHLLAILHITGASDMHYENVINHNGGPVVVDAETLFSVNMRRNEGGKE
                     ADDAMVALAESVFSTGFLPSRIDTVDGSSESVDVGFLGYEPGQTAITASTIFRDIGTDR
                     MSVDFGFGEISEPSVVPPTATSPDAPGTVASAFGQLYDWISAHKREVSNWIDELFSGVH
                     VRAVLDNTRKYYQLLSLATHPEFQMSPELTTVLFHRCGIGRMEHVTPAVIRAEIRDLKQ
                     RDIPYFTLRSDETGVYDSQYKAVADPLAMPPLTRARQSLERMSEHKREFNIRTIHSSFV
                     NKTSADLDRPGWGNRSERRNRPAWNSSVLSSNGLDDLVRIIAEQYARFAIRPRNGDPVE
                     WLGATLSNTTQVHPWRFRQLSDGLYAGRSGLSLFLTAASEHLGDSKYADLAEDYLLPRA
                     NERIYSGYAHGLAGLMAALSTYGVHSPCASALLDDLEQKFVSLFEEVEMPWSISSDAAD
                     RRAHGWCHGAPGILVSELVRFRNGSDSRGQQIEELTELVADECFDLNFSLCHGDIGNLV
                     ILQQAADLQDRADLLVKVNQRANALAAEIVPRAMARYNAKTLLNDAFMVSLPGVAYGLV
                     QLQGGGWLPDIFTCGVVQ"
     misc_feature    complement(10061..10063)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10298..10300)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10553..10555)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10640..10642)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10748..10750)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(10832..10834)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12185..12187)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12206..12208)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12236..12238)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(12536..12538)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(12756..12938)
                     /gene="allorf_0999194_0999376"
                     /locus_tag="allorf_0999194_0999376"
                     /protein_id="allorf_0999194_0999376"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MRENAFDAAGSVAKELSLQEIDERAAQTAGGLWTVPTTSTIGLVC
                     TLSWECTRPPRLCGS"
     CDS_motif       complement(12846..12938)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MRENAFDAAGSVAKELSLQEIDERAAQTAGG"
                     /locus_tag="allorf_0999194_0999376_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(12756..12845)
                     /prepeptide="core"
                     /locus_tag="allorf_0999194_0999376_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-2.10"
                     /molecular_weight="3016.5"
                     /monoisotopic_mass="3014.6"
                     /core_sequence="LWTVPTTSTIGLVCTLSWECTRPPRLCGS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MRENAFDAAGSVAKELSLQEIDERAAQTAGG"
                     /leader_location="[12845:12938](-)"
                     /alternative_weights="3034.5"
                     /alternative_weights="3052.6"
                     /alternative_weights="3070.6"
                     /alternative_weights="3088.6"
                     /alternative_weights="3106.6"
                     /alternative_weights="3124.6"
     gene            complement(13388..14008)
                     /locus_tag="CWS50_RS04110"
     CDS             complement(13388..14008)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CWS50_RS04110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_127841768.1"
                     /transl_table=11
                     /translation="MTFAYSEDDPPVFTDLSMRFPREGLVALQSPNGSGKSTLVELVSG
                     YLRPGAGRVLVCGHDAASPSARPWRRVVRTRPALYPAMSLYDHLAFSSHLAGSQFHDVL
                     ERAGRYRLEDWLDTRADELSSGTERKLWLIMCTLGDFDVVMLDEPFIALDDQARAELNR
                     EMCRWREEGRLVVVAAHGSPEGFQPTATLRLPPPRTTGKEEKE"
     gene            complement(14005..15399)
                     /locus_tag="CWS50_RS04115"
     CDS             complement(14005..15399)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841769.1"
                     /transl_table=11
                     /translation="MTATPVTAAALLWAYDAATRFGLRWRPRTLLAVVTGLTVLAVVPV
                     LALALLVGRLGAATDVTPPWPALGAAWAVWQLAHTAVSQKREELTAPVLAPLMRAVDLG
                     MPQWFLVRFAVPAVVKGLFTGLAASGLLVGNGADSTWAAPTLLVIAAGTAAELALMAQL
                     MTHQRGPRQLLTAVLLCLVGALALALVSTSTLPRQLGLVGACAALTGLAAAELRTVAGA
                     AWVPARTRRHRHRTALPLWVPVAVRTLVVLRLGCWVPPVRALLLRFLTLAVLLCVALVA
                     ARTSIPEIGTVVARNGESAARVVTLGALLPALAITDTGVSWYGVRSRCYQLRAAWEAGA
                     CGYGLAVGSTLAHLLDGLLVSGAVSLVCLALAAPPTAAGLLLPVGASLAGPLGSALVPA
                     PQLPDGRCRSSLAGALAGMALLGPHLYAVLTPSAAALPVTATVVLLGGLPWVSLMVIRN
                     ASFSIV"
     gene            complement(15414..15755)
                     /locus_tag="CWS50_RS04120"
     CDS             complement(15414..15755)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS04120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841770.1"
                     /transl_table=11
                     /translation="MLVLTAVSAVCGCGTALLGSTGGIPLAVAGVGASLVLVSLLTRLH
                     ERAVGAWLIFIGAVMLAVTGTLRHTHTLETVPPTLSAWVGIIASGLLAVLAVMTWTERA
                     EASRPSRNF"
     gene            complement(15911..16816)
                     /locus_tag="CWS50_RS04125"
     CDS             complement(15911..16816)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013720.4"
                     /locus_tag="CWS50_RS04125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_127841771.1"
                     /transl_table=11
                     /translation="MSTMIAPSSTSVCHTPLRRTHDRLGARLRTVSGWAMPWSYVGEQA
                     EHRAARHSAGILDLSHTGEVRVEGPGAAAALDGVLADRVSTLAVGRSGCSAIAGPDGGV
                     IDGVLDEVVVHHVGEEEFLLVTSAASRERVAAELVLRCAGTGARVTDLSLDTALIAVLG
                     PRAPEVLCHVVGSGPGIPAALGPAPGQTEPGGDVPDVLCGTGIVARLRCCAIVRATAAG
                     HSVLLARTRRHGQDGFELFCGWEDAEDLWHTITGAAAALPANHGDAADLAVLTPCGLGA
                     HGLLRREAGVAGVTKGPESS"
     misc_feature    16867..16882
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.04"
                     /tool="antismash"
     gene            17096..18841
                     /gene="miaB"
                     /locus_tag="CWS50_RS04130"
     CDS             17096..18841
                     /EC_number="2.8.4.3"
                     /GO_function="GO:0016782 - transferase activity,
                     transferring sulphur-containing groups [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="miaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006549428.1"
                     /locus_tag="CWS50_RS04130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA (N6-isopentenyl
                     adenosine(37)-C2)-methylthiotransferase MiaB"
                     /protein_id="WP_127841772.1"
                     /sec_met_domain="PF04055 (E-value: 1.5e-27, bitscore: 94.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTADTSTSVAPAPSAPALDARGASTVPRTYHVRTLGCQMNVHDS
                     EHMAGLLEGAGYRRAQDVPQAAARATPAGDGGADVVILNTCSVRENAANRLFGNLGQLA
                     EVKRQRPGMQIAVAGCLAQQMGERIVERAPWVDVVFGTHNLDVLPALLERARHNRAAAV
                     ELEESLKVFPSTLPTRRESPYAAWVSVAVGCNNTCTFCIVPSLRGRQRDRRPGDVLAEV
                     EAVAAQGAIEVTLLGQNVNSYGVGFGERGAFARLLRAVGQVEGIERVRFTSPHPAAFTD
                     DVIDAMASTPTVMPSLHMPLQSGSDTVLRAMRRSYRSRRFLALLEKVRARMPQAAITTD
                     IIVGFPGETEEDFQATLEVVEAARFASAFTFEYSPRPGTPAADREDQVPTEVVKERYQR
                     LDALVRRITHEENTAQEGRVVEVLVAEGEGRRDAATARVSGRAVDNRLVHLALPEGLDA
                     GDYAGGAPRPGDMVSVRVTHGAPHHLIADSARCAGPGSAGGPGTPGAVAGGSAGAAGGG
                     GAGGAGGSGGRFWLDDAPALFEVRRTRAGDAWQRRQTEARAVPEPDSAPVPIGMPRIRV
                     GAPTS"
     gene            complement(18884..19906)
                     /locus_tag="CWS50_RS04135"
     CDS             complement(18884..19906)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009233658.1"
                     /locus_tag="CWS50_RS04135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FAD:protein FMN transferase"
                     /protein_id="WP_243118452.1"
                     /transl_table=11
                     /translation="MVATSAGQARAQYLDHNGSALNAPGAPGPGDHLRYSWSLPATGTT
                     WQVRTRHPLGERPREAVTALVEQFEQTWSRFLPSSLVRQAADGRLGQGPLVLALPAGSS
                     TMLDLYDHLYRLTNGRLDPLAGADLVELGYGPGLDFRVRDGAAHRLGAVHGRPTWGTTV
                     SHTGDRLRLEAPVLVDVGAVGKGFLADLVGALLADHGVEELLVDASGDLLVRSSRPVRV
                     GLEQPGRPGHVVGTVETCRGAVCGSGTDRRTWGHGLHHLLDAVTGLPVQQVAAAWVVAS
                     SCAVADGLATALFTTAPQDLARGVQGAPGFDYDFALLRTDGSASVSRGFRDLPAEIFTA
                     "
     misc_feature    complement(19969..19987)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.86"
                     /tool="antismash"
     misc_feature    complement(19971..19991)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.04"
                     /tool="antismash"
     gene            20090..21928
                     /locus_tag="CWS50_RS04140"
     CDS             20090..21928
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008732738.1"
                     /locus_tag="CWS50_RS04140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FTR1 family protein"
                     /protein_id="WP_127841773.1"
                     /transl_table=11
                     /translation="MFSAPTARTGPVPGPVVAALLLLVVLVLSPVVLVTGALSPARASD
                     SDTDHDTWSEAAAVVDERLHSALTKYEDGDTAGAASGFQRAYHSSYKASNMSAAVSETL
                     GEDVAEDHREKFEALRTAAYSLGNDQALSDGVTGLSQEVTEAATQLDATTDLAGPRDYA
                     EEQAAAIASQRAEIQASRTSVNEGRGDRTWTEVAEEMTGLINQGVEEAQAGDGEAGAAL
                     VNDAYYGYYEKLGFEKTVMAAISGSRVSEVENQFKVVRKAMVAQDSTGDVAAQAQLLTT
                     MLAEDAAALDGGAGEISPVRAFLSGSFGQAFLILLREGLEAILVVAAVIAYLVKVGMRN
                     RVRYIYLGVALGLAASGVVAVLFSVLFSSASAHQEVLEGVVALVAMVMLLFTSSWMLSK
                     SSVESWNRYIRDRTEASVSQGGVWALASLSFLAVFREGAETVMFYQALLALDPGGSASV
                     WQGFAAGAAVLVAVFLLIRFTSVRIPLRPFFLVTSAMMAVLVVVFAGGGVHALLEGDVV
                     PATYVVGWPTYDYLGVYPYVETLAAQAVMAVVVIGLALVSAVRRRREAVAAPGEPESSR
                     QEAEEVEQDGAHDSRDSKAPQEAEAVEDAEEGTGSP"
ORIGIN
        1 ttccgaataa tgagttcctc tgcgattccg atgagctcgt caacgccttc acggagttca
       61 atccgaagag cgcggcacga ggcgtgcatt ggcttaaaat gttccctggc tttgaatatt
      121 cggatatgag tttcaccctg gctacggtag gcgcggatac cttcgaatac tgcggtgccg
      181 tattggaggc cttgagtaga aaggccgaga tggggcaagg tcgcgtcaac ccactgacca
      241 tcgaggtaag caaatgctgt catgacgttg ttctgcgttc ccgctggata gcgattctgt
      301 cagcggaacc tacctcaact tcctgcaggt tgttgcggtg gtctcgaatc cgagcagcct
      361 tccagctgac catggctcct gtagaggtcc gcgcgtccgt tttgccccac agtacacgaa
      421 caggaacgcc aaggttgtgt gcgagaactc tagcatgccg ttctgccgac atatggtctt
      481 ctgcagaggg tgcgtgcgag gattcaagaa gcagatctac ttcgtccagg ccgtcatcac
      541 gtcggtggat gtcaaacctg atagtcgagg aaattggggc aatcctggag cacgacagcc
      601 tcaaagtcat atgcggcata gatggtgtta ccgatgtgca gttcatcgag aacacgaccg
      661 atcggggtta tggtgaagtc ctgacctgca ccacgggtgc ggacgagatc accggtgcgg
      721 tatcggatga ggggcttggc accgcggtac aggtgggtga tgacgagttc tccctcccgc
      781 tcatctgact tggggttcag caccatccca gtattgggtt cgatgatctc atagtagtag
      841 ttcaaaggcg tcgtccgcag gcggccgtca ctttgacata cggccaggat agatgcttcc
      901 tgcgaggcat acatacaact gtagatgtcg gcatcccaga gttggccgat ctgcttcaac
      961 aactgcggag tcgccatctc gccaacagtg aggatcactc ggatgcctag agcagaggga
     1021 tcgactcccg aggcgaggag atgccgggcc aggagaatgg tcattccggg tgtgcaggtc
     1081 agaccagtga ttggcagccg ttgaagtagg tgtgaggcgc ggtcgaagcc gacgacaggg
     1141 gaatgtggcc acattttgat gctgctgtgg ccgagacttc gaaatacgtc accgaaggtg
     1201 tcgccggtcg agtgcagttc cgtcggcccc atcacagcga tcgataggtg cgcaccatag
     1261 ttggttaaga ggtctcgata gccttcataa agagcgaccc cagtgcgaat ggaatcctcg
     1321 gcggtgcgtg ggcacggggt ggaggcaccc gtggtgcctg tagtctcgta gtagacccat
     1381 gtgcgattaa ggctcaggct tggtacttca tcaagatgac gccggagatc atctttggta
     1441 gtgaacggca gtgcattgaa taggtgtcgt cgatttcagg cccgcaaggc gattctggta
     1501 gaaaggagag ttgctctggc aatattctat agtttgccgt aagttcgtgg actgccatgt
     1561 atctagcgca tccgcactca tctcaccagt ccattggcgt ttctgggcga cggtaaattc
     1621 cttcgcagtc tcccacaggt ctgcgtctcc gagtggaatc atggctactt ctccttgacg
     1681 ggatagagcg gaagatcgcc ggtgagggag ttaatggcct tcttggggcc acagagacca
     1741 atcgcagcga gttcgaggtc gcgagagatc gtcgacccca gtttggcgat gtactcatca
     1801 taggtcttgc atccctgcgc caggcgagtg aaggggaaag cgtcaatccc agaatcatcc
     1861 tgatcggcgt ggctccacgc ggatgtgagc aattttgcac tgccggccag gacgggaagc
     1921 ggggctaaga tgaccccagg caactcggag tcagccgttt ttgcaggagg acccatgagt
     1981 tcggggaact tgactgcgat cattgccgcg acaatcgagg cggcattgac ggcaaggccc
     2041 gtagggagat gacggtcgac gacgattacg gtcttgtggc cccttttctg gtgttctgta
     2101 ttcataagcg ggactccttt tggaactgag ggatactgtc cagagttctt tgttttcttg
     2161 aagggggaag agtgctgcgc gagctcatga cgacaccgat gatgaccgtg attgcgccga
     2221 ctaacttgag gatggtgacc tcttctccgg cgattacgac cgcccacacg actccgaaca
     2281 cgggcacaag gttcaggatt gcgacagcct ggcttggttt cagcacggtg agcccgaacg
     2341 tgtagagaag gaacgccaga gcggagcagc cgacggcgag atagacaatc aaccagatcg
     2401 caggcgaact gaggttgatg gtcgtcccct ccggaagaag atgtatgagc aggcaaaatc
     2461 cgatcccccc cccagagatt ctgcaagcct gtcgtgggaa gtacgtcgag gtgttggcgt
     2521 gacgccacgt tagtaggctt ccgggttgaa atcatgttgt aggcggtcca cgcaactccg
     2581 ccaaggaaga ggaagagaat cccccaaggt cggtggattg cttcctgggc gggcgcgtcg
     2641 atggtaacga acgctacgcc gatgaaagcg gtcagaactc caacgacgtt gatcagggct
     2701 ggccgacgac ggtgaaatgc tacttcagca agcattgcta taaccggata ggaagccacg
     2761 atcagggcgg catcggtggc ggtagccagg gcaactccat agttctcgag ggtaaaataa
     2821 atcgtgatgc cgactagccc cgcgcccgcg acggacgcgt gggctcgcca aggtgcgcgc
     2881 aggtttgttc gggtgagggc gcagacgatt atcagcagta tggctgcgac caggaacctg
     2941 atcgccccga gggccagttc tcccacgtaa gggagcacga ctttcgttac cgcaaacgag
     3001 gtactccaca gtagggcggc gcccacgacg gcgctgatgt ggggcagtgc cgagtcgcgt
     3061 ctcatggttg ttcgctgtta actgcgagaa tatctgccac gctccaagtc gcgatctgct
     3121 tccatgcttc cttgccccgt tggtggtcgg ggtgagtctg gaaggtgtca tagtcaacgg
     3181 cagtatcaaa tgtgccaacg acgaggaagt cggcagagtc gggcctgcgg ctggtgtccc
     3241 acccgcaagc ccaggtggcg atctccggga tggttgcagg gtggccgccg gtgatcgtgg
     3301 cggcggcctg aacccggggg tcctcgcggg agattcctgg cttcaatgtg aacgcgacga
     3361 cgtgtattag atgagtcccg ttcaatatgg ctttccttcg cttatcggag gtggggcgcg
     3421 cctcgctcag ggtgagggga tcgcaactct ctgggcaact agattcctgc ggttaagagt
     3481 atatattaca tccggatgtt agccaagtgc gggcgagtgt gacgtgcaac gccttctgac
     3541 tggctgtcag tcaggtcccg cacgttctgt atggtggggt cctacgcagc gatgccaggg
     3601 gtgctgcctg cagaacgtgc gggcaccgtg ttgcgtctag tgttgcgtgt cgctagttgt
     3661 tggatgtgtt gtgggagagg cggggtgtgg ccacgttgtg ttgctcctgg cccgctgctg
     3721 catgaggggg gactgcgagg tctttgagtc ctggacccgt tcgcgtagcg tgcggtctcg
     3781 tctggttgcc aggtcgcgga tcgtcctgct ggcggcccag aacgtgctac acatcgagac
     3841 cggtctggcg tgtggggggt ttcgtgccaa acggtggtga cctggcgggc gcagtccttc
     3901 cggttggcca ccgtccctgc ggttgatatg cgcgctgttg tgtggactgc tagtgccaag
     3961 gctgctcctg tcctggctga caatctggtg gccgtgctca ccgccgcgcc cggccaggag
     4021 cccctcctgg agtcctacgc ccacgagaac ctgggcactg tggcctccct gggcatcggc
     4081 aagggggtgg cccgtatcct cgggcacagc ctgcgcgggt tcgtggcctg gacggcgcac
     4141 cgtggctacc acgtctacgc cgtgcccacc ctcaaccgca aggtgcgcat catgatggac
     4201 tggttcgccg ccgtggtgtt ccgcagggac ctggcctcct tcgggtccgt ggcggcaccg
     4261 ggggtggcct tcgcccgggc caccgccaac gacgcccgga tcgcctcccg gcaccaccag
     4321 ccgggctgag gccggaggga ggcggcggca gggcgggttc cggtcctgct gctgagggga
     4381 ccgggactcg ggcacgggag gctcatgcgg ctgccaggtc ctcgacagga cgcctgcgtg
     4441 acgctgcgta cgcgggcagg agggcagcga gcgtgccggc gacggcggcc ccagccagga
     4501 tggcggccag ctgtccccac ggtacgtgca gggtcatctc gacttccgat gctgactgcc
     4561 cgagtgtggt gacgccagcc caccccagga ggaccccggc taccaggccg agcgcggtcg
     4621 acacgatggc cgtcagcccg gcctcggtgc agatcatggc catgagctgt cctcgtccca
     4681 ggcctactgt gcgaaggagc gcggactccc gacgccgttc gaccaccgac agcgcggccg
     4741 tgttgccgat accgacgaag gcgatgacga ccgcgacagc cagcagggcg agcaccacca
     4801 tgagcatggt gtcgaggatc tggttgtagt aggcacgctc ctgggcgcct ccggagacgt
     4861 tgatgtcctc gtcgagggcc gagatgtcag tcatgaccga ctgaatgtcg gtggggctca
     4921 tcccgtcctc cagccggagc tgcagccgag tgacatctgg gctggagtcg atgtcgacga
     4981 gttcagacga cgcgacttgc acgatgcctt cgggcacgtc ctcgtccacg acgaccacca
     5041 gcgtcgtctc accgtcagcg ccacgtgcgg tgatgtgctg gccgccatac cgagcggccg
     5101 ggtcatccgg gctcacgtgg acgctgcctg cctgcgggac ggagacctct gagcgggcga
     5161 cactgctcgt cgcctgctgg tccacgcctt ctgcgacggc ctgctgcaca gtggtcgagg
     5221 cgctctccag gtccacggct cctgtgagga tctccgcgct ggcgacaaca tccggcacgt
     5281 tcgtgatagc tgcgatcgtt tccgtgtcaa tcgcctggcc gggcgctgtc tcagcgatga
     5341 ggtcaatcgg gcgccggtcg tcgatctgag caaccacgga ctcacgtgca gagctgacgc
     5401 ccgttgtcag catcgcgagc agaatgctgc caataaggag ggcggccccg gttgcagcgg
     5461 tgcgtcgtct gttgcgattg acgtttgctg cggccaactg tgtgggtgcg gacacgggcg
     5521 agatgagcat ccccaggagc ctcacggtta atgggagcag gaccgacgat accacgagaa
     5581 ctccaaggct ggcgacgagg ccaccagcaa cggccacagc aattgatccc cgtcctgccg
     5641 cgtgcaccat tgcgactgcg ccaagaactg tcagccctgg tccgatgacg gccgccgcaa
     5701 ccggtacccg tctcgtggag acagcctcaa gaggccgcag ggcggcaatg gggcgcacct
     5761 tggtagcgtt gcgagccggc cccagcgcgg acaccgtggt cacgacggtg ccgcacgcag
     5821 tcgccccggc caccatcagc gggggtatgg agaaggccga cagcggtagt ccggtgccgc
     5881 ccgaggcgct tgctgacacg agtgcagctg cgacaccagt accgatggcg gcaccagcgg
     5941 cagagaagac cagccccaca atgcctgcct ccagcaggat caggcggtac acctgggcaa
     6001 cgcctgcccc gatgcaccgc aggagggcca gctctgcggt ccgctgggcg acaagcacac
     6061 ggaacgtgtt ggcgatgacg aacccggaca cgagcagtga caccgccccg aacacgagca
     6121 tcatgttggt cagcagcgtg ctgctgcccg acagctcggc aagctggtgc tcgacagcct
     6181 cctcacgcgt gaggactgac agggatgagc cgacaacgac atgctcggcg acacgggccg
     6241 acagcgcccc aggcgagacc ccctcggagg cgctcacaag tattcccgtg gtcacagccg
     6301 acggcccaag tgcctcaaac gtcgcctcag tcgtgatcag tacaggggtt ccctggctga
     6361 aaccagcgtt ggcagctgag gtgagcccga cgacggtgag gtcagaagac ccaccgtgac
     6421 caactgcgtt cgtcaccctg agagtatcac cgactgtcac ccccagtgcc tcagcgttgc
     6481 cgtcatctat cgccacctca ccaggggcgc tcggccagtc tcctgacgac agctcctgcc
     6541 accggttctg cggtgacagc aggggctcca cacttgcatt ggcgcgtcgc gcgccgaagg
     6601 cgacctgcac gtaggacgac cgttgcgcgt ctgctgccgc aacctcctca agtctgtgca
     6661 ggccctcaag agcggttgcg acctgctcgt cgatatcagc agtctcagcg tcgttgtcgg
     6721 tgaccgcgac ctgaaggtcg gcctggtcca tctgggctgt gaggccgtca accattgtct
     6781 gcctgtagga cgaggacagc agcaaggtcg tcacgacgaa ggcaacagac agcgtgaccg
     6841 ccagaccagt cgcaatcagc cgaccgacgt gtgcccggac ggaggagagc agtacctggt
     6901 tcatgaggtg ggctcctcgt cgtcagactc cagcctgctg agcgcctcaa gcacggcgcg
     6961 ctgcgtcggc tcctgtatgg tctcgcgcgc cttgccgtct gcaagaatga ggacctcatc
     7021 cgcgtatgag gcggctttcg ggtcatgcgt caccatgatc actgtctggc cgagttcgga
     7081 gaccatgtcc ctcagcaggt acaggatccg tgtgccagag ctggagtcca ggtttcccgt
     7141 gggctcgtcg gcaaagacaa cggctggctg cgtcatgacc gcccgtgcga tggcgacgcg
     7201 ctgctgctgc ccgccggaga gctcgtgcgg cctgtggctc aggcggtccc cgataccgag
     7261 ctccttgaca accagcgaca cccactcctt gtcctgcttc ttgcgcgcga tcttgagtgg
     7321 gaggaggatg ttctgctcgg cggtgagtgt ggggacaaga ttgaatgact ggaagatgaa
     7381 accaatgcgg tcccggcgca tcctcgtcag ctgacggtcg cgcagtcgcg tgatattggt
     7441 tccctcgatc cagacctcgc ccgcgtcaag cgagtccagc ccggccatgg tctgcatgag
     7501 cgtggacttt ccggaaccag atggccccat caccgccaga aaacttcctt gagcgacctc
     7561 gaggtctacc cctcctaaag ccgtcactgc cgcctcgccc gaaccatacg tcttccgaag
     7621 gttgaccgct cgtactgccg ccttgcttga ttgcatacta gtcctctctt gtttttgcga
     7681 tcgatgctgg aagtcgattg cctgtgttca gcatctaggg tactccaaat agaacttatg
     7741 catcatcgaa cttgggtgcc atgtcccact ttcaggatca tcctcccgga ggagctgacg
     7801 gtcatcctcc agggcgagcc gtcgaggggt cgctcccggc accgtcgtct ggtcgcgatc
     7861 cgtcccacaa cgagtcctca cttctcgacc gcaggtacaa ctcactgtag gcgccgcccc
     7921 tttcgatcag ttcctgatgg cggccccgtt ccactacttt cccgttgtct ataacaaaaa
     7981 tgatgtcagc gtcaatcacc gttgacagcc gatgggcgat caccacgcga gtcgcagaaa
     8041 gtccactaaa aaacttggtg acccgagcct ctgccgtgtt gtccaatgag ctagtggctt
     8101 cgtcgaggac gacgatacgc gccttcttca atgcggcccg tgtgagcgcg attctctggc
     8161 gctggccacc cgagaaattc tgccccattt gtgccaccgg agtgtccaac cccaatggca
     8221 gtgaacatat gtcatcttcg aaccctacat ttctggcggc ttccatgata tccgtgtcgg
     8281 tgaccttgcc tgcccccatt ataaggttgt ctcttaaagt tccggtgtca aggacaacgt
     8341 tctgagggac atatgcgaca ttggcgtaga attgatgtct gtcaaattcc gatacagcac
     8401 gtccgtcgat ctcggtacga cccacggatg gttcatggag ccctacgatg aggcgaccaa
     8461 gggtactttt tcctgaaccc gagcgaccaa ccagcgcgac cgtcgctcca gagggaatac
     8521 taagagtgac atcggacagc actggattag tgaaagaatc atatgagaac gtgacgttgt
     8581 cgaccacaac agcggcaccc ggcgcgggag tttcgtggcc gcgaaacgtc gagtcttccg
     8641 gccggataag tatgtccgtg acccgctcaa gtaacgtcca cccttgggcg acctgggaga
     8701 aagagcccgt cacctgagag acctggccaa gcaagaagcc tgcaagagcc tgcacagaga
     8761 cgatcagagc cgcgtcaaca gcacctgacg cacctgcagt cacgatcaag acgatgagga
     8821 tcgacgagct gcatactagc actcagcgca gtaaagacgc cctgtatact ttggaggcca
     8881 accgaatagc gttggacgct attattcgag gttcgccacc tttgaatgta ggcgtcctcc
     8941 atcgcgttgg ttctgatgga ctccagcccc gagactgcag agacctggat cgattgcaac
     9001 tctgcccggc gccgggtctc ttcgagagag aaccgtcgaa cccctcgtcc agacgctagc
     9061 gcgagtacta cgagaaggac gatcaaacca acagccacga taccggctaa tggagacacg
     9121 acggtcaacc agatgatcag ggttgtcacc atgatcgccc caacgactac gacgataaag
     9181 tcggtggtga tgagcatgcg aagtcgctga accgagtcta aagtgaagag aaggtcgccg
     9241 acacctctat gagccaggtc accataagga agcctcatca tgcgactaaa cacagtttgc
     9301 gacatcgact taccgactgc tgtagccgcg atgagcgaga cgatcgagcg ggtaagtgtc
     9361 aaaagggcgt atcccaacgc aataccagca agcacggaaa gcggccacag taaactgctc
     9421 gaccctgcta tatccattga gaatgtcgcc gacagaagtt gaggtagcca cagtgtcgca
     9481 agggccgatc caagtgctac ggcgagcgta atcaagagca gaaggacgtg tgatctcgca
     9541 agccgccaaa gtaccgaaaa cgcggtaggc acgtttcgtc gtactggttc gggatgaggg
     9601 tcgatagtga tcgcgtatcc gccgaacttg tcgctgaatt cctggaagcc taagcggatg
     9661 actccagcac ccggatcaac tatgcgaatt ctgacattat ttctggggtc gaccactacg
     9721 tagtggttgc tattccagtg gcagatcgca ggctctcgta accctattac ctcatcagca
     9781 gtaactgcga acacgtgcgg agtcgctcct tcttgacgca ggatctccgc aatatgcgca
     9841 atgttcaatc catccctgcc aacggtgtat cttaaccgaa ggtcgttcat ggtaaccgaa
     9901 gaaccttgtg accgtaatag aatcgcgcag cagcacagag cgcactccgt ctggttcagt
     9961 tggcgcacaa gttttggccg acgacgggca cggactcggc tcattgaacc acgccgcaag
    10021 tgaagatatc cgggagccaa ccgcctccct ggagttgcac taatccgtaa gccacaccag
    10081 ggagactgac catgaaggcg tcgttcagga gggtcttcgc gttgtaacgc gccatcgcac
    10141 gaggaactat ctcggcagca agggcgttgg ccctctgatt gactttaaca agaagatctg
    10201 ctctgtcttg cagatcggca gcttgctgga gaatgacgag gttgccgata tccccatggc
    10261 agagagaaaa gttgaggtca aagcattcgt cggcaactaa ctccgtcagc tcctcaatct
    10321 gctgaccccg ggagtctgac ccgttcctga accgaacaag ctcactcacg agaattccag
    10381 gtgctccatg gcaccatccg tgcgcacgcc ggtctgctgc gtcgctacta atcgaccacg
    10441 gcatctccac ctcctcgaac aaggagacaa acttctgctc caagtcatca agaagcgccg
    10501 acgcacaggg gctgtggact ccatatgtcg agagcgccgc catcaatcct gctaagccat
    10561 gagcgtaccc actgtagata cgctcgtttg cccggggtag gagatagtct tccgccagat
    10621 ctgcgtattt ggaatcgcct aaatgttctg acgcggcagt taggaatagt gagagacctg
    10681 aacgaccggc gtagaggccg tcgctgagtt gccgaaatcg ccatgggtgc acctgggtcg
    10741 tgttcgataa cgttgcgccc aaccattcaa ccgggtcccc attccgtggt cgaatagcga
    10801 accgggcgta ctgctcagcg atgatcctaa ctaagtcatc aaggccgttc gaggagagca
    10861 cactagagtt ccatgctgga cggttgcgtc gctccgacct gtttccccaa ccagggcggt
    10921 ccaagtctgc gctggtcttg ttgacgaaac ttgagtggat cgtccgaatg ttgaattcac
    10981 gtttgtgttc tgacattctc tcaagggact gacgcgccct cgtcaaggga ggcattgcca
    11041 gtgggtccgc gacagccttg tactgggagt cgtagacccc agtttcgtcc gagcgcaggg
    11101 tgaagtacgg tatgtctcgt tgcttgaggt cgcggatctc tgcccggatg acggccgggg
    11161 tgacgtgttc catccgtccg atgccgcacc ggtggaagag aactgttgtc agttccggtg
    11221 acatctgaaa ctcagggtgt gttgctaggc tcaatagctg atagtatttt ctggtattgt
    11281 ccaacactgc acggacgtga acacctgaga acaactcgtc gatccagttc gacacttctc
    11341 gcttgtgagc actgatccaa tcataaagtt gcccaaatgc actcgctaca gttccaggag
    11401 cgtctggtga cgttgcagtt ggtggcacga ctgatggttc gctgatctct ccgaacccga
    11461 aatcgacgga catcctgtct gttccgatgt cgcggaatat ggtacttgcc gtgattgcgg
    11521 tctgtccggg ttcataaccg agaaacccga cgtcaaccga ctccgatgag ccgtcgactg
    11581 tatctattct ggacggaaga aatcctgttg agaacacaga ctcagcgagc gcaaccattg
    11641 cgtcgtcggc ctctttacct ccctcgttgc gccgcatatt gaccgaaaat agggtctccg
    11701 cgtcgaccac cactggtccg ccgttatgat tgatcacatt ctcgtagtgc atgtccgacg
    11761 cgccagtaat gtgcaggatc gcaaggagat ggccgcattt ccgaaagtat tcgtcagcgc
    11821 agcccccgtc tttcatgttc gcgtattctt gccatccgtg atcatctgag tcgattattc
    11881 ggagcgtcgg gagattggtg gcggcgcttt ggttgaaccg ttccacgagt cgcccgaaac
    11941 cgagttcggc gcccatctgt cgcggtttat acacgatgcg gttattatta ttctcgaact
    12001 cggcaatgag aacagattgg ccgccggcat gcgggtcgct tccggctgag gtcagggaga
    12061 ggagtgctgg gttggagccc acgattgcct ggaactggtc gtccttcttg atgcgctcca
    12121 gtctgacgag gaaggtgcgc aacgtcttgg cggcttcggc cctgagatag gaaatttgat
    12181 tacttaactc aggaaacacc cgcaataatc ctctttcaaa ttcctcgctt gcacttaacc
    12241 tgcagaagta ctcgtagcgc tcctcgctgg agttgccttg tagttgtccg ttgtcgcgca
    12301 gaacgtgcat cgctgcgatg agggtacggg atgacacctg ctgaactcga tcgactagaa
    12361 ccaaccaagc tgattctgcc aggtctagcg cgtgcttgat tgaaacctct gcgccctcaa
    12421 aaattttctg gagaacgacc cgatcagcat ggcatacgcg tcgggcaaaa ccgtcgaatc
    12481 cgagatattc ctgcgaactt tctgtcggtc gcacgggggc cacactgctg agctttaaaa
    12541 cattgtgcgc aggactgggg accattgcgg ggtccatact ggagacctcg gccaggagga
    12601 ggttaactgc ctcgatgtct ggcagttcgg gaaagaggtc acgtacacgc tcaggctcat
    12661 agtaggtcat aagttttccg ctcatagtca tgtctgtgcc ggagcagcag cgacgctgct
    12721 gctccggcac agatcagcag attgctaagg acagttcagg agccgcaaag gcgaggcggc
    12781 cgtgtgcact cccatgatag cgtgcagaca aggccgatag tgctggtcgt cggcactgtc
    12841 cacagaccac cagcggtctg ggccgccctc tcgtcgattt cctgcagcga cagttccttc
    12901 gccacgctgc cagcggcatc aaacgcattc tcgcgcatga tttatctttt ctcttgtcga
    12961 tcccctgcca cggtgacagg tagtttgacc gtaatccgcc tggcttgcat aagcaacccc
    13021 gtcgccttcg cggcaaaact gttgtcagtg gcgtaggcac ataaataatt tcgaccaggt
    13081 gtttttcctg ctctcctcgc tactctgttc gccggtggcg aatctaatgt acccgtttag
    13141 ttccgtgtct gactcgtcaa ggaccaacag tcgcggctgt ggggcgagag tgagccgctg
    13201 ctgcatgctt agcgacagct ggcccagccg tcgccctttc agcgtgctca ggccgacggt
    13261 cttcagcagc tcgtcaacgc gccttcgtgg cagaccaagg ctttgacacc aggatgcaag
    13321 taggtgacgc tgctgggagc cgtagacggc tcccagcctg tgtgcgcgga cggtcgcacc
    13381 cactggttta ctccttctct tccttccccg tcgtccttgg cgggggcagc cgaagcgtcg
    13441 cggtcggctg gaacccctcg gggctgccgt gggcggcgac gacgaccagc ctgccctcct
    13501 cgcgccaccg gcacatctcc cggttgagct ccgcgcgggc ctggtcgtcc agggcgataa
    13561 agggctcgtc cagcatgacg acgtcgaagt cccccagggt gcacatgatg agccacagct
    13621 tgcgctcagt acccgaggag agctcgtcgg cgcgcgtgtc cagccagtcc tcaagccggt
    13681 agcggccagc gcgctccagc acgtcgtgga actgggagcc cgccaggtgg ctggagaagg
    13741 cgaggtggtc gtagagactc atcgccgggt agagggcggg cctggtccgc accaccctgc
    13801 gccaggggcg ggcactgggg ctggcggcgt cgtgcccgca caccaggact cgtccggccc
    13861 ccggcctgag gtagccgctg accagctcga caagtgtcga cttgccggag ccgttggggg
    13921 actgcaaggc tacgagcccc tcgcgcggga acctcatgga gaggtcggtg aagaccggtg
    13981 ggtcgtcctc cgagtaggca aaagtcacac gatcgagaac gacgcgttcc ggatgaccat
    14041 gagggacacc cacggcagac ctccaagcag gacgacggta gcggtgacgg gcagtgcggc
    14101 ggctgagggg gtcaggaccg cgtagaggtg gggtcccagc agggccatgc ctgccagcgc
    14161 ccctgccagg gaggaccggc agcgtccgtc tggcagctgc ggcgcgggta cgagcgcgct
    14221 gcccaggggg ccggccagcg aggcccccac cggcaacagg agccctgccg ccgtgggagg
    14281 ggctgccagg gcgaggcaga ccagactgac ggcgccggag accaggagac cgtcaagaag
    14341 gtgggccagg gtgctgccga cggccagccc gtagccacag gcacccgcct cccaggcggc
    14401 ccgcagctgg tagcaccggc tgcgcacgcc gtaccagctg acccctgtgt ccgtgatcgc
    14461 cagggcgggc agcagcgccc cgagcgtgac gacacgagcc gcagactcac cgttgcgtgc
    14521 caccaccgtg ccgatctcag ggatgctcgt cctggcagcg accagggcca cgcacaggag
    14581 cacagcgagc gtcagaaacc gaagcagcag cgcccgcacc ggtggcaccc agcaccccag
    14641 ccgcagcacc accagcgtcc gtaccgccac aggcacccac aggggcaggg cggtacggtg
    14701 gcggtgccgc cgtgtacggg ctggcaccca ggctgcgccc gctaccgtcc gcagctctgc
    14761 ggcggctagg ccagtgagtg cggcacaggc gccgacaagc ccgagctggc ggggaagcgt
    14821 gctcgtcgag acaagggcaa gggcgagggc acccacaagg cagagcagca cggcagtgag
    14881 cagctggcgg gggccgcgct ggtgcgtcat gagctgggcc atgagagcga gctcggcagc
    14941 cgtgcccgca gcgatgacga gaagggtcgg ggcggcccag gtgctgtccg ccccgttgcc
    15001 cacaagcagg ccgctggccg ccaggccggt gaagaggccc ttgaccaccg ccggtaccgc
    15061 gaaccggacc aggaaccact gaggcattcc caggtccacc gcccgcatga gtggtgccag
    15121 caccggtgcc gtcagctcct cccgcttctg ggagactgct gtgtgtgcca gctgccagac
    15181 agcccaggcg gctcccaggg caggccaggg cggggtgacg tcagtggcgg cgccgagccg
    15241 accgaccagc agtgccagcg caagcaccgg caccactgcc agcacggtca gcccggtgac
    15301 gacggcgagg agcgtcctgg gcctccatct caggccgaag cgtgtggccg cgtcataggc
    15361 ccacaggagc gccgccgctg tcacgggggt ggccgtcatg gcagtctgcc tgatcagaag
    15421 ttcctgctgg ggcggctcgc ctcagcccgc tcggtccagg tcatgacggc gaggacagcc
    15481 agcaggccgg aggcgatgat gcccacccag gcgctcaggg tgggtgggac cgtctcaagg
    15541 gtgtgcgtgt ggcgcagcgt cccggtgacg gcaagcatga cggcaccgat aaagatcagc
    15601 cacgcaccca ccgcgcgctc gtggagcctg gtgagcagcg acaccaggac cagtgaggca
    15661 ccgactcccg cgacagccag gggtattccc cctgttgagc ccaggagcgc cgtgccgcag
    15721 ccgcagacgg cactgacggc agtcagtacg agcatgaggc ggcgtagtgg gcgtccagct
    15781 gtaggtcctg tcgtgcgtcg tgccatggtg ccttctagag tgcgaccgga gacaacgtca
    15841 tgagcaccgt aacagacacg tgtccctcgg gtcgaggatg cgactagccg cttctgggag
    15901 gcctggttgt ctaggacgac tccggtccct tagtcactcc agccactccc gcctcccggc
    15961 gcagcaggcc gtgggcgccc aggccgcagg gggtgagcac cgccaggtcg gccgcatcgc
    16021 catggttggc gggcagcgcg gcagcggcgc cggtgatcgt gtgccatagg tcctcagcgt
    16081 cctcccagcc gcagaacagc tcgaagccgt cctggccgtg gcgcctggtg cgggccagga
    16141 gcaccgagtg ccccgcggcc gtggcgcgca cgatggcgca gcagcgcagg cgcgccacga
    16201 tgcccgtccc gcacaggacg tcggggacgt ccccgcccgg ctcggtctgg ccgggtgctg
    16261 gacccagggc cgcagggatg cccgggccgg agcccacgac gtggcacagc acctccggtg
    16321 cgcgtggccc caagaccgcg ataagagcgg tgtctaggga caggtcggtg acacgggccc
    16381 cagtgcccgc gcagcgcagg accagttccg ccgccacgcg ctcgcggctg gcggcactag
    16441 tgaccaggag gaactcctcc tcgccgacgt ggtggaccac gacctcgtcc agaacgccgt
    16501 cgatgacacc gccatcagga cccgcgatcg ccgagcagcc cgatctgccc actgccaggg
    16561 tggagacgcg gtcggccagg accccgtcca gcgctgctgc cgctcctggt ccctccaccc
    16621 tgacctcccc cgtgtgggac aggtccagga tcccggccga gtgacgggcc gcccggtgct
    16681 ctgcctgctc gccgacgtag gaccagggca tggcccagcc gctgacagtg cgcagacggg
    16741 ctcccaggcg gtcgtgggtg cggcgcagcg gcgtgtggca cactgaggtg ctcgacggcg
    16801 cgatcatggt gctcatgggc tctccctggg tcctcctggt ccttcccggg gccttgccga
    16861 ccccgtactg gtctggtcct ggcctgtctc ggtgtcttct ctcagtgtct tcctggtgtc
    16921 ctgatctggt gcagcctggc gagtcgcggt cgcccctgcc tgctctgcct acgatacctc
    16981 gcttctggct gagactcgtg ccctgccctg taggggcgcc gcagcagcac gacgcctccc
    17041 gtctgctgcc gacccgctgt ctatccaccg tctgtccgcc gtagaatcac tgccgatgac
    17101 cacggcagac acctcgacct ccgttgcccc cgccccgtcc gccccggccc tggacgcccg
    17161 gggcgccagc accgtgccgc gcacctacca cgtgcgcacg ctgggctgcc agatgaacgt
    17221 ccacgactcc gagcacatgg ccggcctcct ggagggggcc ggctaccggc gtgcccagga
    17281 cgtgccgcag gctgcggccc gggccacccc ggccggtgac ggcggggccg acgtcgtcat
    17341 cctcaacacc tgctcggtgc gggagaacgc cgcgaaccgc ctgttcggca acctcggcca
    17401 gctggcggag gtcaagcgcc agcgccccgg catgcagatc gctgtcgccg ggtgcctggc
    17461 ccagcagatg ggggagagga tcgtcgagcg ggcgccgtgg gtggacgtcg tcttcggcac
    17521 ccacaacctg gacgtgctgc ccgccctgct ggagcgcgcc cggcacaacc gcgccgccgc
    17581 cgtggagctg gaggagtccc tcaaggtctt cccctccacc ctgcccaccc gcagggagtc
    17641 accctacgcg gcctgggtgt cggtcgccgt gggctgcaac aacacctgca ccttctgcat
    17701 cgtgccctcc ctgcggggca ggcagcgtga ccgccgcccc ggtgacgtcc tggccgaggt
    17761 cgaggccgtg gccgcccagg gcgccatcga ggtgaccctc ctggggcaga acgtcaactc
    17821 ctacggggtg ggcttcgggg agcggggcgc cttcgccagg ctgctgcggg ctgtgggcca
    17881 ggtcgagggc attgagcggg tgcgcttcac cagcccccac ccggcggcct tcaccgacga
    17941 cgtcatcgac gccatggcct ccacccccac cgtcatgccc agcctgcaca tgccgctgca
    18001 gtccggctcg gacacggtgc tgcgcgccat gcggcgctcc taccgctccc ggcgcttcct
    18061 ggccctcctg gagaaggtgc gcgcccgtat gccgcaggct gccatcacca ccgacatcat
    18121 cgtgggcttc cccggggaga ctgaggagga cttccaggcc accctggagg tggtcgaggc
    18181 cgccagattc gcctccgcct tcacctttga gtactccccc cgcccgggca cgcccgcagc
    18241 ggaccgtgag gaccaggtgc ccaccgaggt ggtcaaggag cgctaccagc gcctggacgc
    18301 cctggtgcgc cgcatcaccc acgaggagaa caccgcccag gaggggcgcg ttgtggaggt
    18361 gctcgtcgcc gagggggagg ggcgccgtga cgccgcgacc gcccgggtct cagggcgtgc
    18421 ggtggacaac cggctggtgc acctggcgct gcccgagggc ctggacgcag gtgactacgc
    18481 cggtggcgcg ccgcgacccg gtgacatggt gagcgtgcgc gtcacccacg gcgcccccca
    18541 ccacctcatc gccgactccg cccggtgcgc gggaccaggc agcgcgggtg ggccggggac
    18601 gccgggcgcg gtagcaggtg gcagcgccgg tgctgctggt ggtggtggtg ccggtggtgc
    18661 tggcggctca gggggccgct tctggctcga cgacgccccg gctctcttcg aggtccgccg
    18721 tacccgggcg ggggacgcct ggcagcggcg ccagaccgag gcccgcgcgg tcccggagcc
    18781 ggactccgcc ccggtgccca tcggcatgcc gaggatccgc gtcggcgccc cgacgtcctg
    18841 aggactcgta ggagccacag gagtcacaca ggagtcacag aggtcacgcg gtaaagatct
    18901 ctgcgggcag gtcgcggaag ccgcgtgaga ccgacgccga cccgtcggtg cgcagcagcg
    18961 cgaagtcgta gtcaaacccc ggggcgccct ggacgccccg agccaggtcc tggggcgcgg
    19021 tggtgaacag tgccgtagcc aggccgtcgg ccacggcgca ggagctggcc accacccacg
    19081 cggccgccac ctgctgaacg ggcaggccgg tcacggcgtc gagcaggtgg tggagcccgt
    19141 ggccccaggt gcggcggtcc gtgcccgagc cgcacaccgc gccccggcag gtctccacgg
    19201 tacccacgac gtgccccggc ctgcccggct gctccagccc caccctcacg ggccgcgacg
    19261 agcgcaccag caggtcgccc gaggcgtcta ccaggagctc ctccacgccg tggtcggcga
    19321 gaagggcgcc taccaggtcc gccaggaacc ccttgcccac cgcgccgacg tcgacgagga
    19381 ccggtgcctc gagtctgagc ctgtcgccgg tgtggctcac ggtggtaccc caggtcggtc
    19441 ggccgtgaac ggctcccagg cggtgcgcgg caccgtcacg cacccggaag tcgaggccgg
    19501 ggccgtaccc cagctcgacc aggtcggcgc cagccagcgg gtcgaggcgc ccgttcgtca
    19561 gccggtacag gtggtcgtag agatcaagca tcgtggagct gcctgcgggc agcgctagca
    19621 cgagcggtcc ctgccccagg cggccgtccg ccgcctgccg gaccagggag gaggggagga
    19681 accgcgacca ggtctgctca aactgctcca cgagagcggt taccgcctca cggggccgct
    19741 ctcccagcgg atgcctggta cggacctgcc aggtggtccc cgtggcgggc agggaccacg
    19801 agtacctcag gtggtcgcct gggccggggg cgcccggggc gttgagggcg ctgccgttgt
    19861 ggtccaggta ctgggcccgg gcctgcccgg cgctggtcgc taccacggct gccgcctcct
    19921 cctgccagcc tttgacgaga gctattacct cagcatagtc ttcgccataa aggaaagcct
    19981 cacctatgct tttggtgatg aacccacaac aacctcgctc atgacctcac cacgacggtg
    20041 acaccctgac cctgccacac gaccctgcca catgaaggac ccctccagca tgttctcagc
    20101 ccccacagcc cgtaccggcc cggttcccgg cccggttgtc gcggctctgc tgctcctggt
    20161 ggtcctcgtg ctgtccccgg tggttcttgt gacgggcgcg ctctccccgg cccgcgcctc
    20221 ggactccgac accgaccacg acacctggag cgaggccgcg gccgtcgtgg acgagcgcct
    20281 gcactcggcg ctgaccaagt acgaggacgg cgacaccgcc ggggccgcct ccggcttcca
    20341 gcgcgcctac cactcctcct acaaggcctc caacatgtcg gcggccgtct ccgagaccct
    20401 cggggaggac gtggccgagg accacaggga gaagtttgag gcgctgcgca ccgcggccta
    20461 ctccctgggc aacgaccagg ccctcagcga cggcgtcacc gggctgagcc aggaggtcac
    20521 cgaggccgcc acccagctcg acgccaccac cgacctggcg ggtccccgcg actacgccga
    20581 ggagcaggct gccgcgatcg cctcccagcg tgccgagatc caggccagca ggaccagcgt
    20641 caacgagggc cgtggggacc gcacctggac cgaggtggct gaggagatga ccgggctgat
    20701 caaccagggc gtggaggagg cccaggccgg ggacggtgag gcgggggccg ccctggtcaa
    20761 cgacgcctac tacggctact acgagaagct cggctttgag aagaccgtca tggcggcgat
    20821 ctcaggcagc cgcgtctccg aggtggagaa ccagttcaag gtggttcgca aggccatggt
    20881 ggcccaggac tcgaccgggg acgtcgctgc ccaggcgcag ctgctgacca ccatgctcgc
    20941 cgaggacgcc gccgccctgg acggcggcgc gggcgagatc agccccgtgc gggccttcct
    21001 cagtgggtcc ttcggccagg ccttcctcat cctgctgcgt gagggcctgg aggcgatcct
    21061 cgtggtcgcg gcggttatcg cctacctggt caaggtcggg atgaggaacc gtgtgcgcta
    21121 catctacctg ggggtggccc tggggctggc cgcctcgggc gtggtcgcgg tgctcttctc
    21181 ggtcctgttc agttccgcct ctgcccacca ggaggtcctg gagggcgtgg tggccctggt
    21241 cgccatggtc atgctcctgt tcacctccag ctggatgctg tcgaagtcct cggtggagtc
    21301 gtggaacagg tacatcaggg accgcactga ggcgtcagtc tcccaggggg gcgtgtgggc
    21361 gctggcgtcc ctgagcttcc tggccgtctt ccgcgagggg gcggagacgg tcatgttcta
    21421 ccaggcgctc ctggccctcg accccggtgg cagtgccagc gtctggcagg gattcgccgc
    21481 aggggccgca gtgctggtgg cagtcttcct cctcatccgc ttcacctcgg tgcgcatccc
    21541 cctgcgcccc ttcttcctgg tgacctcagc catgatggcg gtcctcgtcg tcgtcttcgc
    21601 tggcggcggg gtccacgccc tcctggaggg cgacgttgtc ccggccacct atgtcgtggg
    21661 gtggcccacc tacgactacc tgggcgtcta cccctacgtg gagacgctgg ctgcccaggc
    21721 ggtcatggcg gtcgtcgtca tcggcctggc cctggtctct gcggtgcgtc gtcgccgtga
    21781 ggccgtggcg gcacccgggg agcccgagtc ctcacgacag gaggccgagg aggtcgagca
    21841 ggacggtgcg cacgacagcc gcgacagcaa ggccccgcag gaggcagagg ccgtggagga
    21901 cgcggaggag ggcaccggta gcccgtaagc ctgactctgt gagcctgact ctgactactg
    21961 accggctact gacctaggac cccgccgccc cgggaggacc ggggagcacg gctgtcaact
    22021 tacccacaac cgagcaaagg agcccacatg cgctcactca cgatcacctc cgccgtcagc
    22081 gccctcgtcc tcgccggtgc tctcggcctg gccgcctgct cctccggcgg ctcagacgac
    22141 gcctcctccg ggaccgccgc ctccgactcc gcagctgact ccggcggcga ctcgggtgcc
    22201 ggcttcgagg agttcccggt cggggaggac caggaggctg aggaccagat caacgtggcg
    22261 gtcgtctact tccagcccat cgacatggag ccggctgact ccggcctggc cgccagcgac
    22321 gccgacctcc acctggaggc cgatatctcc gccctggacg gcaacacctt gggctacggt
    22381 gccggcgact tcatccccgg cctcaccgtc gagtacgcca tcacggacaa ggccagcggc
    22441 gaggaggcca ccagcgggac cttcatggcg atgaacgcct cggacggccc tcactacgga
    22501 ggcaacatcg ctcttcctga tgccggggag tatgagctga cgcttactat cgacagcccc
    22561 gagggtcagg gatgggtcct gcacgttgac gacgagacgg gcgtggaggg ccgcttctgg
    22621 accgagccca tcgagctcac ctgggactgg gactacacgc ctcaggagtg
//
