LOCUS       NZ_CP025227            21812 bp    DNA     circular CON 14-APR-2024
DEFINITION  Actinomyces wuliandei strain 299 chromosome, complete genome.
ACCESSION   NZ_CP025227
VERSION     NZ_CP025227.1
KEYWORDS    RefSeq.
SOURCE      Actinomyces wuliandei
  ORGANISM  Actinomyces wuliandei
            Bacteria; Actinomycetota; Actinomycetes; Actinomycetales;
            Actinomycetaceae; Actinomyces.
REFERENCE   1  (bases 1 to 3107761)
  AUTHORS   Zhu,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2017) National Institute for Communicable Disease
            Control and Prevention, Chinese Center for Disease Control and
            Prevention, No.155 ChangBai Road, Changping District, beijing
            102206, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. HGAP 3.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 200.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_004010955.1-RS_2024_04_14
            Annotation Date                   :: 04/14/2024 19:14:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 2,606
            CDSs (total)                      :: 2,544
            Genes (coding)                    :: 2,496
            CDSs (with protein)               :: 2,496
            Genes (RNA)                       :: 62
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 50
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 48
            CDSs (without protein)            :: 48
            Pseudo Genes (ambiguous residues) :: 0 of 48
            Pseudo Genes (frameshifted)       :: 18 of 48
            Pseudo Genes (incomplete)         :: 37 of 48
            Pseudo Genes (internal stop)      :: 3 of 48
            Pseudo Genes (multiple problems)  :: 9 of 48
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 19:15:49
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 713151
            Orig. end                         :: 734963
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP025227.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21812
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="4"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..21812
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21812
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11812](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11812)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     misc_feature    621..630
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     misc_feature    complement(822..836)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 21.59"
                     /tool="antismash"
     gene            933..1967
                     /gene="iolC"
                     /locus_tag="CWS50_RS02855"
     CDS             933..1967
                     /EC_number="2.7.1.92"
                     /GO_function="GO:0047590 - 5-dehydro-2-deoxygluconokinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019310 - inositol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="iolC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276: PfkB domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010614610.1"
                     /locus_tag="CWS50_RS02855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5-dehydro-2-deoxygluconokinase"
                     /protein_id="WP_127843186.1"
                     /transl_table=11
                     /translation="MTAQVATTAAAGQMPGAEVLTIGRCGIDIYPLQVGVGLEEVESFG
                     KFLGGSPTNVAVAAARYGHGSAVVTGVGADPFGRFVRAEMRRLGVADDYVVTKADYNTP
                     VTFCEIFPPDSFPLYFYREPSAPDLELEVEDVPLQAVREASVFWVSATGLSKDPSRRAH
                     HAALDARGDARGDARGRQAVTVIDLDYRPMFWESREAARREVSAVLPKVTVAIGNREEC
                     EVAVGERDPERAAEALLEAGVELAIVKQGLEGTLARTRDERVEMPVTRVETKNGLGAGD
                     AFGGAVCHGLLEGWSLEKTVFAASTAGAIVSSRLECSTAMPTEPELLDMMRRNREVCAP
                     DLDL"
     gene            1978..2943
                     /locus_tag="CWS50_RS02860"
     CDS             1978..2943
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016444714.1"
                     /locus_tag="CWS50_RS02860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="deoxyribose-phosphate aldolase"
                     /protein_id="WP_243118429.1"
                     /transl_table=11
                     /translation="MGQSTPVEAAGGPGETGAALEAGPPVAVPGSTSRTPLTEAVVEVR
                     ATRPDLVSQVLRHRPRPALEQVRSLMVVACDHPARGALGAGTEPMAMASREDLLARCVE
                     ALSRPGVNGFLGTPDVVEDLALLGALDGKMVWGSMNRVGLQGASFEADDRFSGYDAAGI
                     KASGLDGGKMLTRICYTDPASASLLEACAGAVTSLAERGLTAMVEPFVSCWQGGRLVND
                     LSPEAVIRSVSVAQALGRTSAYTWLKLPCVEDMERVMESTTLPSLILGGEVSRDPEAAM
                     ASWARALALPNVRGLVLGRSLLYPPDDDVAAAVDGAVALL"
     gene            3165..4079
                     /gene="iolB"
                     /locus_tag="CWS50_RS02865"
     CDS             3165..4079
                     /EC_number="5.3.1.30"
                     /GO_function="GO:0016861 - intramolecular oxidoreductase
                     activity, interconverting aldoses and ketoses [Evidence
                     IEA]"
                     /GO_process="GO:0019310 - inositol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="iolB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003784310.1"
                     /locus_tag="CWS50_RS02865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="5-deoxy-glucuronate isomerase"
                     /protein_id="WP_127841588.1"
                     /transl_table=11
                     /translation="MTQQPQPDQPGQSQYVIRAGGLAHDAYELDLTAERAGWEWSSLRV
                     LALEPGRGVDVPGGEHEFLVLPLSGGCTVEVEGEAAGQVLEVTGRDSVFTDITDYVYVP
                     RRTDVRLTSAQGARVALPGARATTDKPLRYCPREEVGTGLRGAGPSSRQVSNYALGNEV
                     ETSHLLACEVLTPGGNWSSYPPHKHDEHTEVERVLEEIYYYQVREGADGAQGFALQRIY
                     PSPGHDIDVCTEVRDGDVVVMPYGYHGPSVAAPGYDLYYLNVMAGPAEDSVWLMTDDPH
                     HTWVRQTWEAQEVDPRLPMTPMN"
     gene            4123..6030
                     /gene="iolD"
                     /locus_tag="CWS50_RS02870"
     CDS             4123..6030
                     /EC_number="3.7.1.22"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016823 - hydrolase activity, acting on
                     acid carbon-carbon bonds, in ketonic substances [Evidence
                     IEA]"
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019310 - inositol catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="iolD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010614614.1"
                     /locus_tag="CWS50_RS02870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione
                     acylhydrolase (decyclizing)"
                     /protein_id="WP_127841589.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-33, bitscore:
                     112.9, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.5e-39, bitscore:
                     129.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNEAYAGTVRLTVAQATIRFLTNQYSERDGVEHRLIEGAFGIFG
                     HGNVAGIGQALLQNEVDPAEGEGEMPYIMPRNEQGAVHAAAAFAKTRDRMSTYMVTASI
                     GPGSLNMVTGAALATTNRLPVLLLPSDQFATRVPDPVLQQLEDPTTLDVTVNDAFRPVS
                     RFFDRVNRPEQLIPSLLNAMRVLTDPAETGAVVIAMPQDVQAEAHDWPVELFRRRVWHV
                     RRPVPEPAALERAVDAIRAAKRPMVIAGGGVIYSQASEELRAFASATGIPVADTQAGKG
                     AINFDHPCAIGGVGSTGGDSGNHIADKADLVIGIGTRYSDFTTASKTQFKNPEVGFVNI
                     NVRAFDAAKQSAEMVVADAREALTALSTALEGYRVSPEYSAEVTAEREAWLVRTQECYH
                     RGHGPLPAQTEVFGALNELMGEEDIMINAAGSMPGDLQALWQARTPVQYHVEYAFSCMG
                     YEVPAALGVKLARPQSEVVSIVGDGTYQMLPMELATVVQENIKVIYVLLQNYGFASIGS
                     LSESRGSQRFGTRYRQRGQGSHLQDEQKVAGVDIAANAESWGLTVYRVSTIEDFRQAYA
                     QARAEDRACMIHIETDLYGPNPPGSSWWDVPVSGVSRLESTQKAYEDYVQDRRPQRHYL
                     "
     misc_feature    complement(6034..6051)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.89"
                     /tool="antismash"
     misc_feature    complement(6186..6200)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     gene            6191..7693
                     /locus_tag="CWS50_RS02875"
     CDS             6191..7693
                     /EC_number="1.2.1.-"
                     /GO_function="GO:0018478 - malonate-semialdehyde
                     dehydrogenase (acetylating) activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017: aldehyde dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003794175.1"
                     /locus_tag="CWS50_RS02875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CoA-acylating methylmalonate-semialdehyde
                     dehydrogenase"
                     /protein_id="WP_127841590.1"
                     /sec_met_domain="Aldedh (E-value: 1e-133, bitscore: 443.5,
                     seeds: 89, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVKHWVSGGPWTGSGTETLPIENPATGEVIDELVLASEEDLDHV
                     VEVAREAQKKWARTSLAKRVDVMFRMRELVNQHADELAELIVREGGKTHGDALGEIARG
                     RETIDFACGINAALKGEFTDQAATGVDVHTLRQPVGVVAGICPFNFPVMVPMWMHPIAL
                     ATGNAFILKVASLVPSASLKIAELYKEAGLPDGLFNVVAGNRTIVTRVLEHPGIDAISF
                     VGSSPVAHIVQDTGVSHGKRVQALGGANNHAIVMPDANMEFAAQHVSAGAFGAAGQRCM
                     ALPVVVAVGDAAERLIPLVKERAQAIVTGPGTDKASEMGPVITRKDLQRIEGWIARAEE
                     GGADVVLDGRGYRPEGEDYQDGFWLGPTIVDRVPTEQSLYCEETFGPVLVVVRAETYEE
                     AIELVNSSEFGNGAAIFTSDGDAARQFVVDVEAGMVGVNVPIPVPVAYYSFGGWKESLL
                     GDHHIHGPEGVRFYTRGKVVTSRWARRGEKVGYVGMNFPTNG"
     gene            7737..>8199
                     /locus_tag="CWS50_RS13390"
                     /pseudo=""
     CDS             7737..>8199
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_049770842.1"
                     /locus_tag="CWS50_RS13390"
                     /note="frameshifted; internal stop; incomplete; partial in
                     the middle of a contig; missing C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTPQGRQWCVDVGVWQG"
     gene            complement(8552..9364)
                     /locus_tag="CWS50_RS02885"
     CDS             complement(8552..9364)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="CWS50_RS02885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_164860058.1"
                     /transl_table=11
                     /translation="MTPSQSDRASAQDWFNDPLLTHISSAHDYRETTATGKLSAAFLFS
                     RYEALNGFSPSSFLDVGCGEGLVLSYVANSDPEVSLTGTDTVAETLSCARQIVPSARLL
                     LREGAPEGSFDTILAHLTLGLWERPLHLLAHAVQQLSTRGLMYIVDINVKDLELGLSYA
                     INDEERSYLRSQYDSAYTLQQFTDLLIRSAPAEQGYEVLTGTSTFAGFDFGTREHLQLM
                     TAPRVITALRQQERSTGSRLPQLLHGWVFARRGTIDNCYSTTARHSPP"
     misc_feature    complement(8630..8632)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(8975..8977)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9251..9253)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(9369..9872)
                     /locus_tag="CWS50_RS02890"
     CDS             complement(9369..9872)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="CWS50_RS02890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_164860059.1"
                     /sec_met_domain="Abi (E-value: 2.6e-10, bitscore: 37.8,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIAAGVLAMPVALLYPNCVGHLLMIAAWAGFGILMPCAVWLITG
                     QRIRKRRHRTDLSTLPAAAVGEELLWRVTAPLLLTHWGLSNYAAVATSAAGFIALHYPK
                     NKRMAFFLYICLFTTFSWAAILSGAVFAAIVFHVAHNFALAFLKPGNGTIMATQPPPPS
                     RNVW"
     misc_feature    complement(9432..9434)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(9768..9770)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    9967..9977
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     gene            complement(10001..10822)
                     /locus_tag="CWS50_RS02895"
     CDS             complement(10001..10822)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="CWS50_RS02895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_127841594.1"
                     /sec_met_domain="PF00881 (E-value: 1.5e-18, bitscore: 64.6,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEIERHATNLVDVVYGNEYLSYDDPTENWFEASKVYRASMAWDA
                     PGVSRLTRSPALQVIATRAGKRFDDLPATQLPAPLTPSISLLEAAEERRSTNYFTGEEI
                     TLTQLATMLDFSYGVTYRPEGLRRRVPSGGALYPIDIYVFASRITKLRHGVYHYDPYRT
                     CLVRLADFRDELLAQALLQEDMVASSAATIVLSASFWRNRFKYDPRSGRFVFLDAGHIM
                     QNLTLITPAISLGGRPFGGFIDDELSQMIGYTNGVDTAPIYAFVVGISGDI"
     gene            complement(10850..11812)
                     /locus_tag="CWS50_RS02900"
     CDS             complement(10850..11812)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: TIGR03604"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03604.1"
                     /locus_tag="CWS50_RS02900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YcaO-like family protein"
                     /protein_id="WP_206610495.1"
                     /sec_met_domain="TIGR03604 (E-value: 1.8e-79, bitscore:
                     264.5, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="YcaO (E-value: 6.3e-56, bitscore: 187.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDFGYDRWTDDLPLWWREGKDAITGTAVWAPAQLIHMAGQWRNE
                     PAVGYATSNGLACGITYTEAALSGLFEVVERDGFMLTWYNKLSLPQIEVISSPTLQDYI
                     ERHFTPTGLDIHLVNMSAFSGIPAILAVVRSRTSVLAPFAIGAASAATVERACVKAATE
                     AMYTRTWMKTEQREGRVIRHPADFSKTLRTFEDHIRLYAGTPIMTEADFLTTSPCRCEV
                     SELPSFDDTSPNRLWHNLVEHLSQQGHRVITFDLTSPDIRDAGVHVVKTVVSGLRPLDT
                     SYNARFMGGQRLLNHAHQLGLCSRPFTVDSLNQAPHPFP"
     misc_feature    complement(10985..10987)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11552..11554)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11603..11605)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(11814..11827)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.54"
                     /tool="antismash"
     misc_feature    12576..12594
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.81"
                     /tool="antismash"
     misc_feature    complement(12952..12967)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.1"
                     /tool="antismash"
     misc_feature    12953..12967
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.67"
                     /tool="antismash"
     misc_feature    complement(13105..13125)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 22.95"
                     /tool="antismash"
     gene            13669..13860
                     /locus_tag="CWS50_RS02910"
     CDS             13669..13860
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CWS50_RS02910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_127841596.1"
                     /transl_table=11
                     /translation="MIEFGMLFSRVDSVSPSVSSRCVRLVEIITVSHELLTTPLSCCRL
                     GAELPTKSMIWTGAQMKD"
     misc_feature    13786..13788
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(13934..14710)
                     /locus_tag="CWS50_RS02915"
     CDS             complement(13934..14710)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013245.4"
                     /locus_tag="CWS50_RS02915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_127841597.1"
                     /transl_table=11
                     /translation="MSTTTLKNPIYLALVQAKFQLSEAVRIPISILMGLFAPSIGLLFF
                     VVPQRAVAEDSELATSAVIGLAVFGVMVNSLFQFATEVSQARERPWGTYTRTLPCGAGS
                     RLLSYLLSSGVLSAASVIPLILLAAFSTEASLTLPRLLAGIAALLVTSAPSMLIGIAIG
                     YLLGSKAAVAVAQVLMLALAFGGGLFIPPHAFPEQFATVSLAMPTRSALELSSWATGVG
                     TEHFAPALVGFFTWTIGLTVICLIRASRDSDREYDS"
     misc_feature    complement(14333..14335)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(14390..14392)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(14691..15605)
                     /locus_tag="CWS50_RS02920"
     CDS             complement(14691..15605)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="CWS50_RS02920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_164860060.1"
                     /transl_table=11
                     /translation="MDMTTGAHPTVAHFDSICKKYRRQAALTDITLQITAGEAVGLVGP
                     NGAGKTTLLALLAGLRRPTCGTVRLFGGDPTNPRSRTRLGMAPQALSLPETARVGEVLA
                     YVQAFYQKTAKISKLVEEFNIGHLLGRQVGGLSGGQRRLVTVALAFVGNPKLVLLDEPT
                     TGLDDESRELLWTRVAARVDAGTTLIVTSHYLEDIERLSQRVVALKEGRVVQDAPITDI
                     RAASRLAKVRISTTTPDAYHAIYRHGESHYRNGVLEFITDDLDETLRWALHNTGTLNNI
                     EVVNNALSAASRNTRIIDEHDNA"
     misc_feature    complement(15042..15044)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15198..15200)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(15426..15428)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    15701..15714
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 16.23"
                     /tool="antismash"
     gene            16591..17523
                     /locus_tag="CWS50_RS02930"
     CDS             16591..17523
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003779297.1"
                     /locus_tag="CWS50_RS02930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_127841600.1"
                     /transl_table=11
                     /translation="MTSKAVNTSDPRYSKLTIGVCPDQWGVWFPEDPKQMDPRQAWEEM
                     AEAGFEVIETGPWGYFPTDPKELQKWCDDYGMRVVAGTGWGILHKEEAWETTLTTFRAI
                     AETHAAVGAEYIVHLPPLYRDDKTWEWTDDRVLSDDAWKLYVEHANALGQMLLDDYDLK
                     MVLHPHGDSHIETPEEIARIFDATDPRYVNLCLDSGHVVYGGGDPVELCRKYPERITYV
                     HIKAFDEAITKEAHEKDWPFGEAVTKGASVCPPAGLPEMHDFVDALADLDKPIYCICEQ
                     DCYPCDPSFPKPNAINMRTYLAECGLGLA"
     gene            17724..18731
                     /locus_tag="CWS50_RS02935"
     CDS             17724..18731
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009393474.1"
                     /locus_tag="CWS50_RS02935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_127841601.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 3.1e-27, bitscore:
                     92.9, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 4.2e-15,
                     bitscore: 53.1, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVRIGLIGAGGMGRAHVERIENELAGGRVVAVADLNLDAAKEVA
                     EPLGATAYGSGAELIADPDVDAVLVATFGKVHAPDVIAAVEAGKYVLCEKPLATTPQDC
                     IAIMDAEQKAGKKLVTVGFMRRFDPGYQEMRATLAGGELGYATLVHCRHRNPSVPEGYV
                     TRNMIDDTAIHEIDTCRYLLNEEIVSVRVDAPRSTSRRFDHLRDPLVLVARTESGVLID
                     DEVNVNIQFGYSIECELVMEAGTIRLGDQNTTVTRDSHGNRNPICRSHVDRFHTAFNQE
                     VQQWIRAVERDEHTGSTSWDGYAATCVVDAALESLENEGREVTVSTIDKPALYA"
     gene            18806..19678
                     /locus_tag="CWS50_RS02940"
     CDS             18806..19678
                     /GO_function="GO:0016853 - isomerase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003779286.1"
                     /locus_tag="CWS50_RS02940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar phosphate isomerase/epimerase"
                     /protein_id="WP_127841602.1"
                     /transl_table=11
                     /translation="MVDIALDPNMYYRTMPTVRTLYKAAELGFEHVELSPNADFHLWHH
                     RPAADDAFVAELNKAQKETGVRVRTLNPVFNWSSPVEEERTAQVSNWRRLLELADQLDV
                     REITSEFSGDRNQARRSEEQWFRSIEELAPHFERYGIRLNMEAHPYDFVELHDPALRLV
                     RAVNKDWIGYEFCCPHAFHLSDGAGDVERMIRTAHEAGKLREVHVADGFNHRANDGNRY
                     IVNPPGADVTVHQHNEVGNGEVDWDAVFSTLRDIRFDGVLSVCVFGWHEHADDINRRVL
                     ARLKDELGA"
     gene            19834..21279
                     /locus_tag="CWS50_RS02945"
     CDS             19834..21279
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009233365.1"
                     /locus_tag="CWS50_RS02945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_127841603.1"
                     /transl_table=11
                     /translation="MTSPAPRSPLRLRLYAWVAGVLLGSLEGVLAVVVAGGAGRGAATA
                     GLPGGGSGVEEATGGALGAANPAPAVPVALVLCAMVVVGALCGPRLSRLLGRRVADLGA
                     GALIVAGALLAAALTGGEGPLGARTAGAVVAGLVGPAAAGAGAGLLLLVAPQVCHELSL
                     PGHRRLMPQAMALMPAGAALVVLGGTLGARWLPDPARGAWLGVLVLGAVHLGVGISLPE
                     SPVWLAERGGDVRAFEALRRLHGNLEAAVAVDWARHEAGMAREQQRLTAADLRIPQIRQ
                     ATVTSVVLVVAQEAPLGAAALVLAPAVADHLGGGARTVAAACVGWGVVSVLALLLGRVE
                     TLERLRFLRVVLGSVVAVVAATVLVTTTSAGGGGPSDADLPGGALAGTVVGCLVALVAG
                     QYVLVLPACQGAVDPQIPPWLVGTQRRLVAVGQSLAHAGAIVVPLLVYQRWGLDVVGWV
                     MFTLTVVALAVVLVRMPRALRAA"
     misc_feature    20206..20208
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(21266..21562)
                     /locus_tag="CWS50_RS02950"
     CDS             complement(21266..21562)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013777.4"
                     /locus_tag="CWS50_RS02950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_164860062.1"
                     /transl_table=11
                     /translation="MGSYGAACTAYRDSALLKQLKELVEDDFLERTDHGEPPPRVDYRL
                     TRRGESLRPLVQTMWDWSDMWAWSEKEFEFSQEEAEQMRQAHETLGVPQVRQP"
ORIGIN
        1 agcagcgctg cccgcctgcg ctcgtggagg agctcggcct ccttcgtggt ggcgttgcgg
       61 gcgccaatga cctgccgggc cgtcgtgggg acgaccccgc tggtgcgcag gagctcgtag
      121 agccctgagg tctccaggtc ctcgcgcgcc ggggcgactg cggccggcac gaggttgtgc
      181 atgatggcga cgggctcgtc gtcggcggcc cggatgcgcg tgaaggtgac gacggggcgg
      241 ccctcctggg tctccagcct gtctgcctcc tcgggggagg cggggtgctc gtcgtagtcg
      301 aggagtgtgg tggagggggt gtgcccggct gccgacaggt ctgccaggag gctggtcagc
      361 tccatcgggc ggtggacgtg gggcggggcg acgacggtac ccacgccgcg gcgccgggtg
      421 agcagcccgc ggtcaaccag gtgctggaga gcctggcggg cggtcggccg ggagacctgc
      481 agacgccggg ccatggacag ctcgtcctcc agccgcgtcc cggggggcag ggtgccgtcg
      541 aggatgagtg tcgccagagg ctcggatatc tggacgtgca ggggggtgcg tatcgtgcgg
      601 tcgatggtga cgtcgagggc gaaggcggcg tcggcgcgag gctcggcggg cgcctcggca
      661 ggtgtggcgt gtgcagtagg cgtggtaggc atggagcacc ttgtggcggt cggtcgtgtc
      721 gggcgcagct cggtagccga cggtgccagc atacggaata cggggcctgg tggtgacgct
      781 gcctgctgcc gcctcgtgtc gctgtcggac cgggacccca aaatgttctg acaaatactt
      841 gacctgaggg ggtggagtgg ggcaggcttc gtcatgtgtc caggccgtcc cgggcacagg
      901 cgatccgccc cgatgacgtg gaagagaacg tgatgaccgc acaagtagcg acgaccgcag
      961 cggccgggca gatgcctggg gccgaggtcc tgaccatcgg acgctgcggg atcgacatct
     1021 acccgctcca ggtgggtgtg ggcctggagg aggtggagtc cttcggcaag ttcctgggag
     1081 gcagtcccac caacgtggcc gtggcagcgg cccgctacgg ccacggctcg gccgtggtca
     1141 ccggggtggg ggctgacccc ttcggccgct ttgtccgtgc tgagatgcgc cgcctgggcg
     1201 tggccgatga ctacgtcgtc accaaggccg actacaacac cccggtcacc ttctgtgaga
     1261 tcttcccccc ggacagcttc cctctctact tctaccgcga gccctctgcc ccggacctgg
     1321 agctggaggt ggaggacgtc cccctccagg cggtccgtga ggcgtcggtc ttctgggtct
     1381 ccgccacggg gctgagcaag gacccctccc gtcgcgccca ccacgcggcc cttgacgcta
     1441 ggggtgacgc caggggtgac gccagggggc gtcaggccgt gacggtgatc gacctggact
     1501 accgtccgat gttctgggag agccgcgagg ccgcccgccg tgaggtctca gcggtcctcc
     1561 ccaaggtcac ggtggctatc gggaaccggg aggagtgcga ggtcgccgtc ggggagcgtg
     1621 accccgagcg tgccgccgag gccctcctgg aggcgggtgt cgagctcgcg atcgtcaagc
     1681 aggggctgga ggggaccctg gccaggaccc gtgacgaacg ggtggagatg ccggtgacac
     1741 gggtggagac caagaacggc ctgggagcag gggacgcctt tggtggcgcc gtctgccacg
     1801 gcctgctgga ggggtggtca ctggagaaga cggtcttcgc ggcctcgacc gccggggcga
     1861 tcgtctcctc ccgtctggag tgctccacgg cgatgcccac cgagcccgag ctgcttgaca
     1921 tgatgcggcg caatcgtgag gtctgcgccc ccgacctgga cctgtgaggt gatggtgatg
     1981 gggcagagca cacccgtcga ggcggcgggc ggaccgggtg agacgggtgc ggccctggaa
     2041 gcgggaccgc ccgtggcggt cccgggctcc acgtcgcgca cccctctgac ggaggcggtc
     2101 gtggaggtcc gcgctaccag acctgatctt gtctcccagg tcctgcgaca ccgccctcgg
     2161 cccgccctgg agcaggtccg ctcgctcatg gtggtcgcct gcgaccaccc tgcccgtggc
     2221 gccctgggtg ctgggaccga gcccatggcc atggcctcgc gcgaggacct cctggcacgc
     2281 tgcgtggagg cgctgtcccg gccgggggtc aacggcttcc tgggaacgcc tgacgtcgtg
     2341 gaggacctgg cgctcctggg tgccctggac ggcaagatgg tgtgggggtc gatgaaccgg
     2401 gtgggtctgc agggagcctc ctttgaggcg gacgaccggt tcagcgggta cgacgccgcc
     2461 ggcatcaagg cctccgggct ggacgggggg aagatgctca cccgcatctg ctacaccgac
     2521 cctgccagcg cgtcgctcct ggaggcctgc gccggtgctg tcacctccct ggccgagcgc
     2581 ggtctgaccg ccatggtgga gccctttgtc tcctgttggc aggggggacg cctggtcaac
     2641 gacctgagcc cggaggcggt gatccgctcc gtcagcgtcg cccaggccct ggggaggacc
     2701 tcggcctaca cctggctcaa gctgccctgc gtggaggaca tggagcgggt catggagtcc
     2761 acgaccctgc ccagcctcat cctgggaggg gaggtgtccc gggacccgga ggctgccatg
     2821 gcctcgtggg cgcgggcact ggccctgccc aacgtcaggg ggctggtcct cggccggtcc
     2881 ctgctctacc cgcctgacga cgacgtcgcg gccgccgttg acggcgccgt cgcgctcttg
     2941 tgagcctggt gcctgcctca gagaccaccg gggcagcctc tagcctctgc agcttctgcc
     3001 accagcgccc gtcccccggg cacggtgccg ttccgcccgg tcctgtcggg acaggcccgc
     3061 cggtacctgc ccccgaccgc cgcacctgta catcacactc aataccgaac cgcatccacc
     3121 ctacctcagg ctttcagccg gacacgacac gtgaggacac tcctatgacc cagcagcccc
     3181 agcctgacca gccaggccag tcacagtacg tcatcagagc cggcgggctc gcccacgacg
     3241 cctacgagct cgacctcacg gccgagcgtg ccgggtggga gtggtcctcc ctgcgggtcc
     3301 tggcgctgga gccggggcgg ggcgtggacg tccccggcgg cgagcacgag ttcctggtcc
     3361 tgccgctgag cggcgggtgc accgtagagg ttgaggggga ggccgcgggc caggtcctgg
     3421 aggtgacagg ccgcgactcg gtgttcaccg acatcaccga ctacgtctac gtcccgcgcc
     3481 gcaccgacgt gcgcctgacc agcgcccagg gcgcgagggt cgcgctgcca ggtgcccggg
     3541 ccaccacgga caagcccctg cggtactgtc cccgtgagga ggtcggcacc gggctgcgcg
     3601 gcgcgggtcc ctcctcccgc caggtgagca actacgccct gggcaacgag gtggagacct
     3661 cccacctgct ggcctgcgag gtgctcaccc ccggggggaa ctggtcctcc taccctcccc
     3721 acaagcacga cgagcacacc gaggtggagc gcgtcctgga ggagatctac tactaccagg
     3781 tgcgcgaggg cgctgacggc gcccagggct tcgccctcca gcgtatctac ccctctcccg
     3841 gccatgacat cgacgtgtgc accgaggtgc gtgacggcga cgtcgtcgtc atgccctacg
     3901 gctaccacgg cccgtcggtg gccgcccccg gctacgacct gtactacctc aacgtcatgg
     3961 ccggccccgc ggaggactcg gtgtggctca tgacggacga cccccaccac acctgggtgc
     4021 gccagacctg ggaggcccag gaggtcgacc cccgtctgcc catgaccccg atgaactgac
     4081 agccactcac tgaccaccag caacgacagg aagaagacac acgtgagcaa cgaggcctac
     4141 gccggtacgg tccgcctgac cgtggcccag gcgactattc ggttcctgac caaccagtac
     4201 tccgagcgtg acggcgtgga gcaccgcctc attgagggcg ccttcggcat cttcggccac
     4261 ggcaacgtgg ctgggatcgg ccaggcgctg ctgcagaacg aggtcgaccc cgccgagggc
     4321 gagggcgaga tgccctacat catgccgcgc aacgagcagg gtgccgtgca cgcggccgct
     4381 gccttcgcca agacccggga caggatgtcc acctacatgg tcacggcctc tatcggcccg
     4441 ggctccctca acatggtcac cggtgccgcc ctggccacga ccaaccgcct gccggtcctc
     4501 ctcctgccct ccgaccagtt cgccacccgg gtgcccgacc ccgtcctcca gcagctggag
     4561 gaccctacga ccctggacgt caccgtcaac gacgccttcc ggccagtgtc ccggttcttt
     4621 gaccgcgtca accggcccga gcagctcatc ccctccctgc tgaacgccat gcgggtcctc
     4681 accgaccccg ccgagaccgg cgccgtggtc atcgccatgc cccaggacgt ccaggccgag
     4741 gcccacgact ggccggtcga gctgttccgc aggcgggtgt ggcacgtgcg ccgccccgtc
     4801 cccgagccgg ccgccctgga gcgcgccgtg gacgccatca gggccgccaa gcgccccatg
     4861 gttatcgccg gtggtggcgt catctactcc caggccagcg aggagctgcg cgccttcgcc
     4921 tcggccacgg ggatccccgt ggccgacacc caggcgggca agggtgccat caacttcgac
     4981 cacccctgcg ccatcggggg agtgggatcc accgggggcg actccggcaa ccacatcgcc
     5041 gacaaggctg acctggttat cggcatcggc acgcggtact cggacttcac cacagcgtcg
     5101 aagacccagt tcaagaaccc ggaggtgggt ttcgtcaaca tcaacgtgcg cgcctttgac
     5161 gccgctaagc agagcgcgga gatggtggtg gccgacgcgc gtgaggcgct gaccgccctg
     5221 agcaccgccc tggagggcta ccgggtgtcc ccggagtact ccgcggaggt caccgctgag
     5281 cgggaggctt ggctggtccg tactcaggag tgctaccacc ggggccacgg ccccttgccc
     5341 gcccagaccg aggtctttgg cgccctcaac gagctcatgg gggaggagga catcatgatc
     5401 aacgccgccg gctccatgcc cggcgacctc caggccctgt ggcaggccag gaccccggtc
     5461 cagtaccacg tcgagtacgc cttctcctgc atgggctacg aggtcccggc cgccctgggg
     5521 gtcaagctcg cccggcccca gagcgaggtg gtctccatcg tcggtgacgg cacctaccag
     5581 atgctgccca tggagctggc caccgtggtc caggagaaca tcaaggtcat ctacgttctg
     5641 ctacagaact acggcttcgc ctccatcggc tccctgtcgg agtcccgcgg ctctcagcga
     5701 ttcggcacca ggtaccgcca gcgcggccag ggtagccacc ttcaggacga gcagaaggtc
     5761 gccggagtgg acatcgccgc caacgccgag tcctgggggc tcacggtcta ccgggtctcc
     5821 acgatcgagg acttcaggca ggcctacgcc caggcccgcg ccgaggaccg tgcctgcatg
     5881 atccacatcg agaccgacct ctacggcccc aacccgcccg gctcctcctg gtgggacgtc
     5941 ccggtgtcgg gggtctcccg cttggagtcc acccagaagg cctacgagga ctacgtccag
     6001 gaccgcaggc cgcagcgcca ctacctgtga tattgtccgg acaataggac acgatgcgcc
     6061 agacggacca aggtcctcaa agagggcgta gtgtcatgtc tgtcgacctg gggccgggcg
     6121 acctgcccgg ccccaggcac ctccagaccc cggaggaccc cggggtcacc caagactcaa
     6181 aggagagata atgacagtca agcactgggt ctccggcggc ccgtggaccg gatcgggaac
     6241 tgagacgctg ccgattgaga acccggccac cggcgaggtc attgacgagc tggtgctggc
     6301 ctcggaggag gacctcgacc acgtggtaga ggtggcgcgc gaggcccaga agaagtgggc
     6361 ccgtacctcg ctggccaagc gtgtagacgt catgttccgg atgcgcgagc tggtcaacca
     6421 gcacgcggac gagctggccg agctcatcgt gcgcgagggc ggcaagaccc acggtgacgc
     6481 cctgggggag atcgcccgcg gccgggagac cattgacttt gcctgcggca tcaacgctgc
     6541 cctcaagggg gagttcaccg accaggcggc caccggggtc gatgtccaca ccctgcgcca
     6601 gccggtgggg gtcgtcgcgg ggatctgccc gttcaacttc cccgtcatgg tgcccatgtg
     6661 gatgcacccc atcgccctgg ccaccggtaa cgccttcatc ctcaaggtgg cctcgctggt
     6721 gccctcagcc tccctgaaga ttgctgagct ctacaaggag gcgggcctgc ctgacggcct
     6781 gttcaacgtg gtggcgggca accgcacgat cgtcacccgg gtgctggagc accccggcat
     6841 cgacgccatc tcattcgtgg gctcctcgcc ggtggcccac atcgtccagg acacgggcgt
     6901 gtcccacggc aagcgcgtcc aggccctggg cggggcgaac aaccacgcca tcgtcatgcc
     6961 tgacgccaac atggagttcg ccgcccagca cgtctccgcc ggcgccttcg gggcggccgg
     7021 gcagcgctgc atggccctgc cggtggtcgt ggccgtgggt gacgcggccg agcgcctgat
     7081 cccgctggtc aaggagcgtg cccaggcgat cgtcaccggg ccgggcacgg acaaggcctc
     7141 cgagatgggg ccggtcatca cccgcaagga tctgcagcgt atcgagggct ggatcgcccg
     7201 ggccgaggag ggcggcgctg acgtggtgct cgacggccgc ggctaccgtc ccgagggtga
     7261 ggactaccag gacggcttct ggctgggccc cacgatcgtg gacagggtgc ccaccgagca
     7321 gtccctctac tgtgaggaga ccttcggccc ggtgcttgtg gtggtgcggg ccgagaccta
     7381 cgaggaggcc atcgagctgg tcaactcctc ggagttcggc aacggcgcgg ccatcttcac
     7441 ctctgacggg gacgctgcgc gtcagttcgt ggttgacgtg gaggctggca tggtcggggt
     7501 caacgtgccc atcccagtgc cggtggccta ctactccttc ggcgggtgga aggagtcgct
     7561 cctgggtgac caccacattc acggcccaga gggtgtgcgc ttctacacca ggggcaaggt
     7621 ggtcacctcc cggtgggcgc gccgtggcga gaaggtcggc tacgtgggga tgaacttccc
     7681 gaccaacggg taggtgggca ggccagcagt tcggtacagc ccacgtcaac gcaccactga
     7741 cgccccaggg gcgtcagtgg tgcgttgacg tgggcgtctg gcaggggtag tcgctgcacc
     7801 gtgcggctga gaggctccag gtcagcccgg ctacaaccag gcgctgggct agcagccgac
     7861 aggtggggcg gcccctgacc gaccgcagtt ccaggccgcg ctcctggcct ggtcggctgg
     7921 cgctggttcc accacgccgt gggcggccgc tccaggggcg tgtgccccga gatccttgat
     7981 gacgagacca gggacactgc cgcaggcttc tagtggcgcg ccagcgcctt cttcgcctcc
     8041 ctgggcgtga ctgtgcagga ggtcatgacc ggcgacaggg cctgctaccg gtccagggtc
     8101 ttcaaccagg cactccaggc aaccggggtc gggcaccgct gcacccgccc ctaccgcccc
     8161 cagacaggcg ccaaggtcga gcgcctcaac cccaccctgc aagaggagca ggctggggtg
     8221 gggggcttct cggctgctgg gatcaaagca caactctttg tgaagggtga tctttgtgaa
     8281 gggtgatctt tgtgaagggt gatctttgtg aagggtgaag gaggccgtgc caggggacac
     8341 gctgctgtga cgaaacggct actgccgcca tacacccggt tagtaggcag gaacagttta
     8401 tgggcgaact gagatctagg gtcctcggcc tgtatgccgg gcatcctccc accagtcact
     8461 cgtccccacg agtcactcgc cactgcatag cacgcggcgc aaacatatcc gaaaggaact
     8521 acgtatgtgg ctagaacacg attagattta cttaaggagg actgtgtcga gccgtagtcg
     8581 agtagcagtt atctatggtg ccacggcgtg cgaataccca tccgtgaagt aactgcggga
     8641 gccgtgaacc ggtggatcgt tcctgctgcc tgagggcagt gattactcgt ggagcggtca
     8701 tcaactgcag atgctctcgg gtgccaaaat cgaaacccgc aaacgttgaa gtcccggtaa
     8761 ggacctcata tccctgttcg gccggagctg aacggatgag gagatcagtg aactgttgca
     8821 aggtgtaggc ggagtcgtac tgacttctca ggtaagaacg ttcttcgtcg ttgatggcgt
     8881 atgagagccc tagttcgaga tccttgacgt tgatgtcgac gatatacatc aaccctcgcg
     8941 tcgacagttg ctggacggcg tgggcgagta ggtgtaaagg cctttcccaa agtccaagag
     9001 tcaagtgtgc gagaatagta tcaaaactcc cttcgggtgc tccttcccga aggagcaggc
     9061 gcgctgatgg aactatctgg cgtgcacaag aaagcgtctc tgccaccgtg tctgtgcctg
     9121 ttagtgaaac ttcaggatcg ctgttagcaa cataagaaag gacaagcccc tcgccacagc
     9181 cgacgtcgag aaaactgctg ggagaaaagc cgttaagggc ctcgtatcta ctgaaaagaa
     9241 aagcagctga taactttccg gtggctgttg tttctcgata atcatgcgca gaactgatgt
     9301 gcgtgagcaa tggatcattg aaccaatctt gagccgaagc ccggtctgac tgtgaaggtg
     9361 tcatcgcact accatacatt ccgcgagggt ggagggggtt gtgtcgccat tatcgtaccg
     9421 tttcccggct ttaaaaaagc caatgcaaag ttgtgtgcca catgaaacac aattgctgca
     9481 aaaactgctc ccgacaggat tgcagcccaa gaaaaggtag tgaacaaaca aatatagaga
     9541 aaaaatgcca tgcgtttatt tttagggtag tgcagtgcaa tgaagcccgc cgctgaagtt
     9601 gcaacagctg catagttaga cagcccccag tgtgttagca ggagcggggc tgtcacccgc
     9661 cacagcagtt cttcacctac ggcagcggcg ggaagagtag aaagatcagt gcggtgccgc
     9721 ctctttcgta tacgctggcc agttatcagc caaaccgcac agggcattaa tatgccaaat
     9781 cccgcccacg cggcaatcat caaaagatga ccaacacagt tagggtacag gagtgcaacg
     9841 ggcatagcaa ggacgcctgc ggcaattgtc acgagatcgt agtggcgttg gggcgtgagt
     9901 gacaaattca tctgacccca aatgccggtc ctgggaaaaa atgcaacctg cactggtgca
     9961 gtgagatgca atgtcagtcc gagggatgaa agaactatat tcatatgtca ccagaaatcc
    10021 caacaacaaa agcgtatatc ggcgcagtgt cgactccatt agtatagccg atcatctgag
    10081 atagctcgtc gtcaatgaac ccgccgaatg gtctgcctcc gagtgagatt gctggagtta
    10141 ttagagtcag gttctgcata atatgaccag catcaagaaa cacgaacctc cccgaacgag
    10201 ggtcgtactt gaaacggttt cgccagaaac tggctgaaag cacaatggta gcagcagaag
    10261 atgccaccat gtcttcttgc aacagtgctt gggcaaggag ctcatctcta aaatctgcaa
    10321 gacggacaag acatgttcgg tatggatcgt agtgataaac gccgtgcctc agtttagtga
    10381 tacgactagc gaaaacatag atgtcgattg ggtacaacgc tccgcccgaa ggaacacgac
    10441 ggcgtagtcc ttccggccga taagtaaccc cgtaactgaa atcaagcata gtggcgagtt
    10501 gggtcaatgt aatttcctcg ccagtgaaat agttagtact tcgtcgctcc tccgctgctt
    10561 ctagaagact aatggaggga gtcaatggtg ctggaagttg tgttgctggt agatcgtcga
    10621 accgttttcc ggcacgtgta gcaattactt gcaatgcggg tgaacgggtg agtcgactaa
    10681 cacctggggc atcccatgcc attgaagccc ggtatacctt gctagcctca aaccagttct
    10741 cagtaggatc gtcgtaggaa agatactcat tcccataaac aacgtcaacc aggttggttg
    10801 catgacgttc tatttcactc atttcggtag tgtccttcct ggtcctagat catgggaatg
    10861 ggtggggcgc ctgattcaaa ctgtcaacgg tgaagggccg cgaacatagg ccaagttgat
    10921 gggcatggtt tagaagtcgt tggcccccca tgaaacgagc gttgtaggag gtgtcaagag
    10981 gccgtaaacc agatacgacc gtctttacta catgcacccc tgcatcgcgt atatccgggc
    11041 tggtgagatc gaatgtaatg actcggtgac cttgttgaga caaatgttct accagattat
    11101 gccatagcct atttggggat gtgtcgtcga aagatgggag ttctgaaacc tcgcaacgac
    11161 aagggcttgt tgtcaaaaaa tctgcttcag tcatgatagg ggtgccagcg taaaggcgaa
    11221 tgtgatcctc aaatgtgcgc agagtttttg agaagtctgc ggggtgacgg attactcttc
    11281 cttctctctg ctcggttttc atccaagtcc tagtgtacat tgcttctgtt gcggctttga
    11341 cgcaggcacg ttctacagtc gcagcactgg cagcaccgat cgcgaatggc gcaagtaccg
    11401 aggtgcggct gcggactact gcgaggatgg ctggaatgcc gctgaacgct gacatgttca
    11461 caagatgaat gtcaagacca gtgggcgtga agtgtctttc aatgtagtct tgcagggttg
    11521 gactcgagat tacttcaatc tgcgggaggc ttaatttgtt gtaccaggtg agcatgaagc
    11581 cgtcccgctc gaccacttca aataagccag agagcgccgc ttcggtgtac gtgataccac
    11641 aagcgagacc gttgctggtg gcatagccaa cagcgggctc attgcgccat tgtccggcca
    11701 tgtggatcaa ttgtgcaggt gcccatactg cagttcctgt gatggcgtct tttccttctc
    11761 gccaccacag cggcaggtcg tcagtccacc gatcgtaacc gaagtccttg atgttatact
    11821 actgatcagc aaacatagcg aaatcatcag cgctcagtag gtctagttcg tgcctaagat
    11881 catgagtggt cccatatctt acagatgctg agtctgtcgg tgcgtaggca gcactatacc
    11941 gttccaccgt ctcgccgatt gcagccaggc gggcgctaat gagatcaggt gatcctccac
    12001 cgttgtattg taagtgctac cagggacgtc gaaaagcaaa ctgctatctg tgctgtgggc
    12061 accaacagaa tgagcaagga tgtcgtcaac atcacggagc ttcatgtact cacgacgcgt
    12121 gattcccaca tacggatcag aaagtggcag caagatcgcc gctgcttgct gggtgctagt
    12181 ccactcgctc attgcgttgc cttcgagtct ctactctcta cgctgacagg atcgtcgtga
    12241 aaccaaactt gagggaagcc cgtgtcggct actggggagc agtcgggaca acggggtacc
    12301 ctcaggactc tacgggtttg aacttccaat ccggtgtcac cgatggtgat tgtggtcagt
    12361 ccgccaggca tagtgcatgg cccatggctg cggagcgtga cactttctag aagcagattg
    12421 gaaactatcc ccgcctggat gtaatgtagt gggttcgggc cgaagtcagg ggcagggtta
    12481 tcaataggtt gaagcttaag gagttccgga cggaagatat catcggagaa atttgctgat
    12541 ctgcgaagtt gaaagcattt tatacaggcg gattgatatg ggatacagaa tggtcctacc
    12601 cacgctgttt ccgagtcgaa ggctatcaca ggaagcagcg gtgtgttagt ttttagcgcg
    12661 tggctgttgg caagaaagag cgttggatct atgtaggagt ttgcgactat gacaagtata
    12721 tctccccgcg cttctggaac cgaactgaac acctgtatat tcgggccctg tgccgttgcg
    12781 gctagttgga tggtatccgc taaggcgctc cccggacgag acatcaagga tacagatgtc
    12841 ttcttcaggc gctgttcgat ggtgtcatca gatgcctgac gtcctgggcg tagagcggct
    12901 aagatgactg atggaggata gcgcttctgc gcagtggtca atagacctgc ttcgactaat
    12961 cggtccagca cggccgaaac ctgactgacc gggagagaca tggtttcagc caagtcttcg
    13021 gcagagatgt atccatccat tcccagctcg tgcaacaact cagtggcgaa actggtaact
    13081 ccgtcgccgt gaatagtggt agcgaactta gctgcaacta tgactaaact ttcgtctaga
    13141 gacgccgtct cggcaaaagg tgccgacggt agaacttatc tggtttgagg tcattggcat
    13201 gtgagctcac agttgcctcc tagtgtccgt gagagataag ttgcggagtg agtggctgcc
    13261 ttccaagtat tttcgatagg acctgggtag ttgctgacag cagcggatcg gaagtggtgt
    13321 gttggtagtt ggccacccaa tatgcatctg tgtcagacat tccgtttgcc aggagtttgt
    13381 ctgtgaactc atctggttgc aggcacgcca attcaatgtc catatttaag ttatgtgcca
    13441 tagtgtcgcg aaggtgggtc atcggtatgc gcgcaggccc ggtcaggtcg tacgcttgac
    13501 cttttttctt ggatatgggt tggggtaatc cggctaatag cttcggccag gtctgacgtc
    13561 tgtatccatg ctacaccttc ttcgtggaag gatgacatga gaattccagc tgcttgcgcc
    13621 cacgaccaca gcagcgggag cgataagtct aacggcgagc atcgaagtat gattgagttc
    13681 ggaatgctgt tcagcagggt agactccgtg tcgccgagcg tgtcatcaag gtgtgtccgc
    13741 ctcgtcgaga taataacagt ctcccatgag ttgttgacga cgcctttaag ctgttgcaga
    13801 ctcggtgctg aacttccaac taagtcgatg atctggacgg gtgcacagat gaaggactga
    13861 agcgtctcgg cgaggccatt tcatgccccg atatagtgag caccattgat tgctgacgga
    13921 taggttgtcg gggtcatgag tcgtactccc ggtcgctgtc gcggctggcg cggataaggc
    13981 atatgacagt gagaccgatg gtccaagtga agaagccgac gagtgcggga gcaaagtgtt
    14041 cagtacctac gcccgttgcc caactgctaa gttcgagtgc cgagcgggtg ggcattgcga
    14101 gggagacggt ggcgaactgc tcagggaagg catgaggagg tataaacagg ccgcctccga
    14161 aggcgagtgc aagcatgagc acctgggcaa ccgctactgc tgctttggaa cctagcaggt
    14221 acccaatcgc gattccgatc aacatagatg gggcagaggt gacaagcagg gctgcgattc
    14281 ccgcaagcag gcgaggcaga gtgagcgagg cttccgtgct gaaggctgca agtaagatta
    14341 gcggaattac cgatgctgcg gaaagtactc ctgatgacag gaggtaggat aatagcctag
    14401 atcctgctcc gcagggcagt gtccgggtat aagtgcccca agggcgttct ctcgcctggg
    14461 aaacttccgt ggcgaactgg aacaaggaat tgaccataac gccgaatacg gccaggccaa
    14521 tcactgcgct ggtggctagt tccgagtctt ctgcaaccgc gcgttgcggt acgacaaaga
    14581 acagtaggcc gatgctggga gcgaagagac ccatgaggat gctgatgggt attctcacgg
    14641 cttcactgag ctggaactta gcttgtacta gggctaggta gatggggttc ttaagcgttg
    14701 tcgtgctcat cgattatcct cgtgttgcgg ctggcggcgg agagtgcatt gttaacgact
    14761 tcgatgttgt tgagtgtgcc tgtgttatgc agtgcccagc gcaaggtttc gtctaggtcg
    14821 tcggtgatga actctagtac tccgttgcgg tagtgggact caccgtggcg gtagattgcg
    14881 tggtaggcat ctggggtggt ggtcgagatc cgcacctttg ctagtctgct tgccgctcgg
    14941 atatctgtga taggtgcgtc ttggacgact cgtccttctt tgagggcgac tactcgctgg
    15001 gacaatcgtt cgatgtcttc caagtagtgg ctcgtgacta ttaatgtagt accggcatcg
    15061 actcgtgctg ctactcgcgt ccacagcagt tctcgtgatt catcatccag gccggtcgtt
    15121 ggttcgtcga gtagaactag tttcgggttg ccgacgaatg cgagggcgac ggtcactagt
    15181 cgtctctgcc caccagataa tccgcccacc tgccttccca gcagatgtcc aatgttgaac
    15241 tcctccacca atttagatat ttttgcggtt ttttggtaga acgcttggac atatgcgagc
    15301 acctcgccaa cccttgctgt ttcaggcagg ctcaatgcct gcggtgccat gccgagcctg
    15361 gtacgcgatc gcgggttcgt cgggtcgcct ccaaacagtc ggactgtccc gcaggtcggt
    15421 cgtcgtaacc cggcaagcaa cgccagcagc gtagtcttgc ccgccccatt gggccctaca
    15481 agccccacag cctcacccgc agttatttgc aaggtaatat cggttagtgc cgcctgcctt
    15541 cgatattttt tgcatattga gtcgaagtga gcgactgttg gatgggcgcc cgtcgtcatg
    15601 tccatggatc tagcgtagcg cgttgcgact ttgcattgca aaacactttg tgaggcagac
    15661 atggatttca gcgtgctgtg gagccagtct gtatttcacc tgttattaat atcatagttt
    15721 ctttggttgt gcttgatgta tggtgtgtat tgcgctgatg cagtcagtgt gcagatcttg
    15781 gcgagccgga cgcgagagga ggtggttatg gaagccatcg ccttgccgga tgtatctacg
    15841 atgacgatca cgagtttcgg tgagggtcag cacctgtttg agcctatggc ggctcgatgc
    15901 acgaccacga ccatcatctc cagttccagc tgcttctagg cgtgaggtcg ccatgacttt
    15961 gtgttgtcgc agtgggcatg tggttccgcg aagttgaatg cctttgcgga accacatgtg
    16021 tgtctggctg ggaacttagg tgctttggtg gtgggtgagt gggtctggtg atgagatgtt
    16081 gggtcttgtc gcgcggtggt gcgttgttaa gctgcggcgg tgaagctttg cttgtgtcac
    16141 ttcccctggg gatgcttgtt ctggtgacgg gctcgatccg tggggtctgg tctgggtgag
    16201 gtcggagact gcagggctgt gacgcgtgtg actgccttga ctgtcggcgt gggaggtgtt
    16261 cttgctgcgt atggcgggac cctcctgtgg gtggcgcgag tcaggctggt gcgggcgtgg
    16321 ctgtgaaggt ggtgggggtc ctggccccgc tgctggtctc cgggaccttg tgcgcaagac
    16381 gtcttgcgtg gtagtgcggg tctgttggtg gtcagccgcc ataggccacc tgaagatgtg
    16441 cagcatggga gcctggaggt gtaggcgctg cgggcggggc acgaccaacg ctgtatgtcc
    16501 tgacaaagcc tggacttctt gacgtgggtg cggtaacctc ggtctcacgt ccgaaacgat
    16561 tcggacgaaa cctgcgactg aggagcgaca atgacgtcca aggctgtcaa caccagtgac
    16621 cccaggtact ccaagctgac catcggcgtg tgccccgacc agtggggcgt ctggttccct
    16681 gaggacccca agcagatgga cccccgccag gcctgggagg agatggctga ggccggcttc
    16741 gaggtgatcg agaccggccc ctggggctac ttccccaccg accccaagga gctccagaag
    16801 tggtgcgacg actacggcat gcgggtcgtg gccggcaccg ggtggggcat cctccacaag
    16861 gaggaggcct gggagaccac gctgacaacc ttccgggcca tcgcggagac ccacgccgcc
    16921 gtgggcgcgg agtacatcgt ccacctgccc ccgctctacc gcgacgacaa gacctgggag
    16981 tggaccgacg accgcgtgct ctccgacgac gcctggaagc tctacgtgga gcacgccaac
    17041 gccctggggc agatgctcct ggacgactac gacctcaaga tggtcctcca cccccacggg
    17101 gactcccaca tcgagacccc cgaggagatc gcccgcatct ttgacgccac cgaccccagg
    17161 tacgtcaacc tctgcctgga ctccggccac gtcgtctacg gcggcggcga cccggtcgag
    17221 ctgtgcagga agtaccccga gcgcatcacc tacgtccaca tcaaggcctt cgacgaggcc
    17281 atcaccaagg aggcccacga gaaggactgg ccctttggcg aggcggtcac caagggcgcc
    17341 tcggtctgcc cgcccgcagg cctgcccgag atgcacgact tcgttgacgc cctggcggac
    17401 ctcgacaagc ccatctactg catctgcgag caggactgct acccctgcga cccgtccttc
    17461 cccaagccca acgccatcaa catgcgcacc tacctggccg agtgcggcct ggggctggcc
    17521 tgaggcggct ggaccttccg ggcgctgact gaccgcgtgg ctgcggtgct atgtggcgcc
    17581 ggtgggtgcc cgccgacggc gccgggctgc cctgccgagg tggtctcggc gccaacccgg
    17641 ccgcgccgtg gacactgctc ggcaggccga cttcctccaa tatccaatat cactgactga
    17701 cgctactcaa cgaggagaca accatgagtg tccgtattgg actgatcggg gccggcggca
    17761 tgggccgcgc ccacgtcgag cgcattgaga acgagctggc tggcgggcgc gtcgtcgccg
    17821 tggccgacct caacctggat gctgccaagg aggtcgccga gcccctgggt gccacggcct
    17881 acggcagcgg tgccgagctc atcgccgacc ccgatgtcga cgccgtcctg gtggcgacct
    17941 tcggcaaggt ccacgcccct gacgtcatcg ccgccgtcga ggcgggcaag tacgtcctgt
    18001 gcgagaagcc gctggccacc acgccgcagg actgcatcgc catcatggat gccgagcaga
    18061 aggcgggaaa gaagctcgtc accgtgggct tcatgcgccg cttcgacccc ggctaccagg
    18121 agatgcgcgc caccctggcc ggcggggagc ttggctacgc caccctggtg cactgccgcc
    18181 accgcaaccc ctcagtgcca gagggctacg tcacgcgtaa catgattgat gacaccgcca
    18241 tccacgagat cgacacctgc cgctacctgt tgaacgagga gatcgtctcc gtgcgcgtgg
    18301 acgccccgcg ctccaccagc cgccgttttg accacctgcg tgacccgctg gtgctggtgg
    18361 ccaggacgga gtccggcgtg ctcattgacg acgaggtcaa cgtcaacatc cagttcggct
    18421 actctatcga gtgcgagctg gtcatggagg ccggcaccat ccgcctgggg gaccagaaca
    18481 ccacggtcac ccgtgactcc cacggcaacc gcaacccgat ctgccgcagc cacgtggacc
    18541 gcttccacac ggccttcaac caggaggtcc agcagtggat ccgcgcggtg gagcgcgacg
    18601 agcacaccgg gtccacctcc tgggacggct acgccgccac ctgcgtggtg gacgccgccc
    18661 tggagtccct ggagaacgag ggtcgggaag tcactgtctc taccatcgac aagcccgccc
    18721 tctacgcctg agcctcgctg acagatgccc ctagcgtggt gcgacgacgt cggttggcgc
    18781 tgtcgcaccg gagaggagac cacctgtggt cgatatcgcc cttgacccca acatgtacta
    18841 ccgcaccatg cccaccgtcc gcaccctgta caaggcggcc gagctgggtt ttgagcacgt
    18901 ggagctgtcg cccaacgcgg acttccacct ctggcaccac cgcccggccg ccgacgacgc
    18961 cttcgtcgcc gagctgaaca aggcgcagaa ggagaccggt gtgcgggtgc gcaccctcaa
    19021 cccggtcttc aactggtcct cgccggtgga ggaggagcgc accgctcagg tctccaactg
    19081 gcgccgcctc ctggagctgg ccgaccagct tgacgtgcgt gagatcacct cggagttctc
    19141 cggggaccgc aaccaggccc gccgcagcga ggagcagtgg ttccgctcca ttgaggagct
    19201 ggccccgcac ttcgagcgct acgggatccg cctcaacatg gaggcccacc cctacgactt
    19261 cgtcgagctg cacgacccgg ccctgcgcct ggtgcgtgcg gtcaacaagg actggatcgg
    19321 ctacgagttc tgctgcccgc acgccttcca cctgtctgac ggcgccggcg acgtggagcg
    19381 gatgatccgc accgcccacg aggccggcaa gctgcgcgag gtccacgttg ccgacggctt
    19441 caaccaccgt gccaacgacg gcaaccgcta catcgtcaac ccgcccggcg ccgatgtcac
    19501 cgtgcaccag cacaacgagg tcggtaacgg cgaggtcgac tgggacgcgg tgttctccac
    19561 cctgagggac atccgctttg acggcgtgct gtcggtgtgc gtcttcggct ggcacgagca
    19621 cgccgacgac atcaaccggc gcgtcctggc ccgcctcaag gacgagctcg gcgcctgaga
    19681 cgcggctggg cggatccctg acctgtgctg cggcctcacg ggacgcccgt gaggccgcag
    19741 ccgttcattc ttcccggggc accgcctgtc cccgacaggg gaggtgtgtc gagaccgtat
    19801 cctgccgcct atgacgtaca cggtgagccg gtcatgacct cgcccgcgcc gcgcagcccc
    19861 ttgcggctgc gcctgtacgc gtgggtggca ggtgtgctcc tgggctccct ggagggggtg
    19921 cttgcggtcg tcgtcgcagg tggcgctggc aggggcgccg caacggctgg cctcccaggt
    19981 gggggcagcg gtgtggagga ggcgactggc ggtgcgctcg gcgcggccaa cccggcgcct
    20041 gccgtgccgg tggccctcgt cctgtgcgcc atggttgtgg tgggggcgtt gtgcggcccg
    20101 cggctgagcc gcctgctcgg caggagggtg gcggacctgg gggccggggc gctgatcgtg
    20161 gccggggcgc tgctggcggc tgccttgaca gggggtgagg gtcccttagg cgccaggacc
    20221 gctggtgccg tggtggctgg cctggtcggg cctgctgccg caggggctgg tgcggggctc
    20281 ctgctgctgg tggcccccca ggtctgtcac gagctctccc tgcccggtca cagacgcctc
    20341 atgccccagg cgatggcgct tatgccagcg ggtgctgcgc tggtggtgct ggggggaacc
    20401 ctgggtgcgc ggtggctgcc ggatcctgcg cgcggggcgt ggctgggtgt cctcgtgctg
    20461 ggtgccgtgc acctgggggt gggcatcagc ctgcccgaga gtccggtctg gctggcggaa
    20521 cggggagggg acgtcagagc cttcgaggcg ctgcggcgcc tgcatggcaa cctggaggct
    20581 gctgtcgccg tcgactgggc ccgccacgag gcaggcatgg cccgcgagca gcagcggctg
    20641 accgccgccg acctcaggat tccccagatt cgccaggcca ccgtgaccag cgtggtgctc
    20701 gtggtggcgc aggaggcgcc cctgggggcc gctgcgctcg tcctggctcc tgcggtggct
    20761 gaccacctgg gaggaggcgc gcgcacggtc gccgccgcct gcgtgggctg gggcgtcgtc
    20821 agtgtcctgg ccctgctcct ggggcgggtg gagaccctgg agcggctgcg cttcctgcgg
    20881 gtggtgctgg gcagcgtggt cgcggtggtg gctgccacgg tgctggtgac caccactagc
    20941 gctggtggcg ggggaccgtc agacgcggac ctgccaggag gggcgctggc cgggactgtc
    21001 gtcggctgcc tcgtcgcgct ggtggcaggc cagtacgtcc tggtgctgcc cgcatgccag
    21061 ggtgcagtag atccgcagat tcccccgtgg ctggtaggca cccagcgtcg gctggtagcg
    21121 gtggggcagt ccctggccca tgccggcgcg atcgtggtcc ccctgctggt ctaccagcgc
    21181 tggggcctgg acgtggtggg ctgggtgatg ttcaccctga ccgtggtcgc gctggcggtg
    21241 gtgctggtcc ggatgccgcg tgcgctcagg gctgcctgac ctgtgggact cccagggtct
    21301 cgtgtgcctg gcgcatctgc tccgcctcct cctgggagaa ctcgaactcc ttctcgctcc
    21361 aggcccacat gtcgctccag tcccacatgg tctggacaag cggcctgagg ctctctccgc
    21421 gacgggtcag gcggtagtcc accctgggcg ggggctcgcc gtggtcggta cgctcaagaa
    21481 agtcgtcctc aaccagctct tttagttgct tgagcagcgc ggagtcccga tatgccgtgc
    21541 aggcagcacc gtagctgccc acagtgcctg acgtccgcca gggcgacgta gaagaggatc
    21601 tcaatcctcc acttcccgcc gataaccttc tgacgggacg tgattgcagg gcaccacgtg
    21661 atcttggggg cctctggcat tgaccccacc tcttgtcgtg ggtactgaga gaaaggcagt
    21721 actaggaagt cgtggccgcg ctcgctacgg tagtcatgcc gcaggacatg agcaagtctg
    21781 aggccggtgg ccgcgtgcgt tgtcccgtga gg
//
