LOCUS       NZ_CP034587            10990 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   NZ_CP034587
VERSION     NZ_CP034587.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2018) School of Life Sciences, Ludong University,
            186 Hongqi Road, Zhifu Distric, Yantai, Shandong 264025, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 247.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003970715.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:34:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,575
            CDSs (total)                      :: 6,474
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 104 of 198
            Pseudo Genes (incomplete)         :: 118 of 198
            Pseudo Genes (internal stop)      :: 12 of 198
            Pseudo Genes (multiple problems)  :: 30 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:02:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3518205
            Orig. end                         :: 3529195
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034587.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10990
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="butyrolactone"
                     /region_number="19"
                     /rules="AfsA"
                     /tool="antismash"
     cand_cluster    1..10990
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="AfsA"
                     /kind="single"
                     /product="butyrolactone"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10990
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5990](+)"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5990
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="AfsA"
                     /neighbourhood="5000"
                     /product="butyrolactone"
                     /protocluster_number="1"
     gene            complement(209..652)
                     /locus_tag="EKH77_RS15485"
                     /old_locus_tag="EKH77_15485"
     CDS             complement(209..652)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008746400.1"
                     /locus_tag="EKH77_RS15485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15485"
                     /product="rodlin"
                     /protein_id="WP_126914948.1"
                     /transl_table=11
                     /translation="MLKKVLATAALSASAVGAVASPAMAIGNDQDVLNANGARTGYGNT
                     ATGGKESPQMSLIQGTLNKPCIAIGKLGIQSVLALINIGVQDIPILTSQQQQQCTDNST
                     INDGDDPLSHILDEIPILSGNGSGNSEGGEGEEFESHEHGHGH"
     gene            complement(812..1156)
                     /locus_tag="EKH77_RS15490"
                     /old_locus_tag="EKH77_15490"
     CDS             complement(812..1156)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKH77_RS15490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKH77_15490"
                     /product="hypothetical protein"
                     /protein_id="WP_126914949.1"
                     /transl_table=11
                     /translation="MVRVDMARHVAAAIDYYAHDYYATGLAAAGGTRHDAPADTAPDDR
                     APAGRSPAEPLPAVFEGLSVPVRTAASLLGLSPWTVAHLIERGELRSERGGQYRYVTLT
                     SIFSYRRMTR"
     gene            1404..2003
                     /locus_tag="EKH77_RS15495"
                     /old_locus_tag="EKH77_15495"
     CDS             1404..2003
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155537.1"
                     /locus_tag="EKH77_RS15495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15495"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_126914950.1"
                     /transl_table=11
                     /translation="MGSTPQPRKSDTRERIQRTALGLFVSRGYEKTSLREIAEELGVTK
                     AALYYHFKTKEDILGALSDQLGRPVDELIAWGREQPATLATKRELLRRYSAALREAAPI
                     YHILQENQATLRELAIGETLRKRVTAVSGLLHDGEAPLDTRVRLSSALLAVHFGALTMD
                     ALPGDREDKREAVLRVALEILDSTAHEAPAPAVTAG"
     gene            complement(2270..2974)
                     /locus_tag="EKH77_RS15500"
                     /old_locus_tag="EKH77_15500"
     CDS             complement(2270..2974)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003991562.1"
                     /locus_tag="EKH77_RS15500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15500"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_126914951.1"
                     /transl_table=11
                     /translation="MAKQDRAIRTRQSILEAAAVVFDERGYDAATITEILARAEVTKGA
                     LYFHFASKEELALAVIDAQMMTDMPAAEPGRASKMQELVDMGMIFAHRLLVDPLLRGSV
                     RLTLEHGSTNLNRSGPFHGWTELHTRVLAEGKERGEVLPHVVPADTAELIVGAYAGINT
                     MSQAINNRADLERRATILYEHVMPSVAVPSVLARLDMAPGRGARALAEAERQRLRAAEA
                     EAALEAAPAGVG"
     misc_feature    complement(3117..3135)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.72"
                     /tool="antismash"
     gene            complement(3173..3946)
                     /locus_tag="EKH77_RS15505"
                     /old_locus_tag="EKH77_15505"
     CDS             complement(3173..3946)
                     /EC_number="1.1.1.47"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (12-178). E-value: 3.1e-16.
                     Score: 51.7. Matches aSDomain:
                     nrpspksdomains_EKH77_RS15505_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019886500.1"
                     /locus_tag="EKH77_RS15505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15505"
                     /product="glucose 1-dehydrogenase"
                     /protein_id="WP_126914952.1"
                     /sec_met_domain="adh_short (E-value: 1.5e-36, bitscore:
                     124.6, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7.5e-31, bitscore:
                     106.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSDQGLLRDRIALITGASSGIGAAAARVFAREGATVVLAARRED
                     RLRELVAELREAGAEAAYVVTDVTRREDTARAVAFAVERYGRLDSAFNNAGWGAGRTPL
                     HLMDDDLYDAIMDVNARGTWNCLRDEIAAMLESGDGGSIVNNSSVGGLLATPVAAPYVA
                     AKHAVIGFTRAAAAEYAASGIRVNAVAPGTTRTEVVAEWFERHPGIEAALHAASPQPRT
                     AEPEEIAEAAAWLLSDRSSFVTGATVPVDGGFHMV"
     aSDomain        complement(3413..3910)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKH77_RS15505_PKS_KR.1"
                     /evalue="3.10E-16"
                     /label="EKH77_RS15505_PKS_KR.1"
                     /locus_tag="EKH77_RS15505"
                     /protein_end="178"
                     /protein_start="12"
                     /score="51.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALITGASSGIGAAAARVFAREGATVVLAARREDRLRELVAELREA
                     GAEAAYVVTDVTRREDTARAVAFAVERYGRLDSAFNNAGWGAGRTPLHLMDDDLYDAIM
                     DVNARGTWNCLRDEIAAMLESGDGGSIVNNSSVGGLLATPVAAPYVAAKHAVIGFTRAA
                     AAE"
     CDS_motif       complement(3818..3907)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKH77_RS15505_0001"
                     /evalue="6.20E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="EKH77_RS15505"
                     /protein_end="43"
                     /protein_start="13"
                     /score="12.5"
                     /tool="antismash"
                     /translation="LITGASSGIGAAAARVFAREGATVVLAARR"
     gene            complement(3964..4746)
                     /locus_tag="EKH77_RS15510"
                     /old_locus_tag="EKH77_15510"
     CDS             complement(3964..4746)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003953814.1"
                     /locus_tag="EKH77_RS15510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15510"
                     /product="HAD family hydrolase"
                     /protein_id="WP_240667367.1"
                     /transl_table=11
                     /translation="MVESLRRIRLAAVNIDGVLLNDTFSPVIHRFVTDRGGRYTADVEY
                     AVFSQPQLVAARALGAAAGVDWAPEKVLEVYFRERAAYLEHDPVRLLDGAVELLRRLRA
                     LGLRVVCYGGLDAAHFDRHLGAHADLFDGPRYVCTNDFRPGVKEITTEIFGLGLDEAVF
                     VDDVARVAETARELGVAFIGHPSGFAHGYQGELMRAAGVRHLAGSLAAIDESLLRTVDA
                     EAAAGTSWAAATGPGDAQRTGIMEPVDGAAPDGTAAGA"
     gene            5001..5990
                     /locus_tag="EKH77_RS15515"
                     /old_locus_tag="EKH77_15515"
     CDS             5001..5990
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     butyrolactone: AfsA"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018546905.1"
                     /locus_tag="EKH77_RS15515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15515"
                     /product="ScbA/BarX family gamma-butyrolactone biosynthesis
                     protein"
                     /protein_id="WP_240667368.1"
                     /sec_met_domain="AfsA (E-value: 1.9e-23, bitscore: 80.9,
                     seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQTTSAPASFAPALPRLTTTVPREYVHRAAVAEVLLTGWRKVEA
                     NRFRVWAQWPRGHSFFSPLRGVQHDPMLVAETVRQIGSLLAHAEFDVPLGFQFLMWHLD
                     YSLRPRHTALESTPAELVLDVECSEIRRKGRSFGGMRYDVVIRRDGAVAATGSASYTCT
                     SPEVYRRLRGDRIPGTPPALGAPVRPRRVGRRSPFDVVLAEEDAPGAARWRLRADGRHP
                     VLFDHPVDHVPGMVLLEAARQAAAVLSPDPVILPTELTSSFHRYAELDSPIWIEAARET
                     AAGGRNGPATTVVRGHQDDELLFTCALTSIRPRNAPAPPGDTAVNPSE"
     misc_feature    5709..5711
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6080..7144
                     /locus_tag="EKH77_RS15520"
                     /old_locus_tag="EKH77_15520"
     CDS             6080..7144
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004947428.1"
                     /locus_tag="EKH77_RS15520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15520"
                     /product="alpha/beta hydrolase-fold protein"
                     /protein_id="WP_126914954.1"
                     /transl_table=11
                     /translation="MGLSLTSTAFLVLLIVASVLAVVATLLLWARVPGPAPLRWLGRVL
                     LIGLCQATAICVVAVSINSSYGLYASWDDLFGRKSTGPVSMPGPPAHRARFSQADYGMQ
                     ETYFRGSRSQLSGQVLVWTPPQYEQARYRRTAFPVVVLLHGVPGSPQSWMELGRMPGAY
                     ERLLREGATRPFILAVPIINPGGVDTDCSDVPGRKVATWLSEDVPELLRTHFRTGRGPE
                     SWGVLGISTGGYCAAKLPLQYPRAYAAGAALDPDPLNGDGGAIPDPGLRKRNSPTWLVR
                     HTDADVGLFVATSRQDRDSPPRYVEEFQREAAGGKVRLRTMLLPSGGHNYGTWINLYPA
                     AFSWMSGQLRGGPG"
     gene            complement(7238..8578)
                     /locus_tag="EKH77_RS15525"
                     /old_locus_tag="EKH77_15525"
     CDS             complement(7238..8578)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1104: putative esterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980391.1"
                     /locus_tag="EKH77_RS15525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15525"
                     /product="alpha/beta hydrolase-fold protein"
                     /protein_id="WP_126914955.1"
                     /transl_table=11
                     /translation="MGLTSRSLLYTVVFAAVLCVGLTVWIWPRLAGRGVRPVLGRLGVI
                     ATTQLTIMASLALAVNSWGGFYGTWNQLLGRVDKAPVNVNEMGRNGPYATVGASKDGLV
                     QPAGPQGLDKVGGIPRGPADKEGKVQSVRIVGQRSRAINPAFVYLPPQYFQKQYERHRF
                     PVMVVISGYPGGIMNLAQHLQVPQTAGSLLKENKMQPTVIVMLRPTIAPPRDTECVDVP
                     DGPQAETFFTKDLPDALKTTYRVGHDPSAWGVLGYSSGGTCALELAMRQPDVYPAAAAL
                     SGDYKVGNDLTTGNLFGSGPDAKRKQQEHDLIWRLGNMPVPRVNVLVTSSKKGEKNYAE
                     TEKFLGAVKQPMTASSIILPEGSHHFTTWRREIGPVLEWMSQQLTFPQDTADKPKPRDG
                     GKPSGTPEPSQAPKPSQEAKPSEDVKPSEAPKPSEEDKPSERPEAAE"
     misc_feature    complement(8547..8562)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.33"
                     /tool="antismash"
     misc_feature    8557..8572
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.11"
                     /tool="antismash"
     misc_feature    complement(8608..8621)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.25"
                     /tool="antismash"
     misc_feature    complement(8803..8817)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.35"
                     /tool="antismash"
     gene            8902..10254
                     /locus_tag="EKH77_RS15530"
                     /old_locus_tag="EKH77_15530"
     CDS             8902..10254
                     /GO_function="GO:0016702 - oxidoreductase activity, acting
                     on single donors with incorporation of molecular oxygen,
                     incorporation of two atoms of oxygen [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004947423.1"
                     /locus_tag="EKH77_RS15530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_15530"
                     /product="carotenoid oxygenase family protein"
                     /protein_id="WP_126914956.1"
                     /transl_table=11
                     /translation="MNRNPDAEVRNPYLGGLYAPVTDETTAYDLPVTGRLPESLRGRYL
                     RNGPNPVHVDDPAGYHWFGGDGMIHGVRLRDGRAEWYRNRWVRSDAVAGRLGEKLLHGR
                     RHRGLDFAPNTHVQSFAGHCLALVEGGALPYELDPELHTIGPFDFHGTLPGGFSAHPVT
                     DPHDGELHAVAYCPAWPYVQYVVAGRNGCVRRHVEIPVAGSPMMHAFSLTERYVLLYDL
                     PVVFGRDPRDGGAHPRWVPDRPARLGLLPRDGGAAETRWLETEPCFVFHPMNAYQRDDG
                     RITVHLAVYDRYFDRRRPLPGDHLARLERWTVDPVAGTVRRLPLDDRPVEYPRVDPRRL
                     TVRHRFGYVMRERVAGRDTALIKYDLERGTSEEFEVPAGGDVGEGVFVPAAPGAAEDEG
                     WVLAYAYDPARGAGELVVLAAQDFAAGPVARVHLPGRVPLGFHGSWIPDCP"
ORIGIN
        1 gagcgcggcc gtggccacaa ccttcttgaa cacgttcttc cctcagctcc ggtcgacgaa
       61 cttcctgact cactgcctaa ctcggagccg ccgccgaggt tatctgcctt cattccttcg
      121 gcccagcgcg ggaaaaaggg gagtcccccc gcagcgggtc ccgcacaccc gccgcagagg
      181 gactctttcc gttcgccgga cggtccggtc agtgaccgtg accgtgctcg tgcgactcga
      241 actcctcgcc ctcgccgccc tcgctgttgc ccgagccgtt gcccgacagg atcgggatct
      301 cgtcgaggat gtgcgacagc gggtcgtcgc cgtcgttgat cgtcgagttg tcggtgcact
      361 gctgctgctg ctgcgaggtg aggatcggga tgtcctggac gccgatgttg atgagcgcga
      421 ggacggactg gatgcccagc ttgccgatgg cgatgcacgg cttgttcagc gtgccctgga
      481 tcaggctcat ctgcgggctt tccttgccgc cggtggccgt gttgccgtaa cccgtcctgg
      541 cgccgttggc gttgagaaca tcctggtcgt ttccgatggc catcgccggc gaggcgacgg
      601 cgccgaccgc ggaagccgac agggcggccg tggcgagaac cttcttgagc acgtctatgc
      661 ctttcgatcg agtagcgccc ccacagagaa agcgttctga ataactccgg cccattccct
      721 gggttgcggg gtttcactcg ttcgatccag tgggacgcgc tatccccgat cggcgttcac
      781 atcggcgttc atagcgaaaa ccaaaaggcc ctcaacgggt cattcgccga taggaaaaaa
      841 tgctggtcag ggtcacgtac cggtattgcc cgccgcgttc gctgcgcagt tcgccgcgct
      901 cgatgagatg ggccacggtc cacggggaga gccccagcaa cgaggccgcc gtgcgcaccg
      961 ggacactcag cccctcgaat accgcgggca ggggctccgc cggggaacgg ccggccggag
     1021 cacggtcgtc cggcgcggtg tcggcgggcg cgtcatgacg cgtaccaccg gccgcggcga
     1081 gacccgtcgc gtagtagtcg tgtgcgtagt agtcgatcgc ggcagcaaca tgtcgtgcca
     1141 tgtcgacgcg caccatcccc tcggtccagt cacatttacg tacctgccgc caggctagtc
     1201 agctaggccg gaagcgtagg aggcccctag ccgggcgtca agtatggttt cgccttgcct
     1261 gccgtccggc tagattccct gcgtcgcacc tgtcccggcc gccacaaggg caccgatgag
     1321 gcagggcacc cgttacttac ttgccgacgg gctagttagg gacataaaga aagcgcacca
     1381 cggaccagca ggagagtgag cccatgggca gcacacccca gccacgcaag agcgacaccc
     1441 gcgagcgcat ccagcggacg gccctcggcc tcttcgtctc gcgcggctac gagaagacct
     1501 cgctgcggga gatcgccgag gagctcggcg tcaccaaggc cgcgctgtac taccacttca
     1561 agaccaagga ggacatcctc ggcgccctct ccgaccagct cggccgcccg gtcgacgagt
     1621 tgatcgcctg gggccgggag cagcccgcca ccctggccac caagcgcgag ctgctgcgcc
     1681 gttacagcgc ggccctgcgc gaggcggcgc cgatctacca catcctccag gagaaccagg
     1741 cgaccctgcg ggagctcgcc atcggcgaga cgctgcggaa gcgggtgacg gcggtctccg
     1801 ggctgctcca cgacggcgag gcgccgctgg acacccgggt gcgcctctcc agcgcgctgc
     1861 tggccgtcca cttcggcgcg ctcaccatgg acgcgctacc gggggaccgg gaggacaagc
     1921 gggaggccgt cctgcgggtc gcgctggaga tcctggattc caccgcccac gaggcccccg
     1981 cgccggccgt caccgcgggc tgacgccgct cggcgcggtg aaaagtcggg ccggccgctc
     2041 gggaaaagtg gctggccaat acacccttca ataccgtcac gtcggtttgc tctgctgccg
     2101 acgaatactt tcggccgcca ctttccggcc agcttaagag aaacgggtgc cctgcggcac
     2161 cctatttacg gaataagaca ctccgccccg gtgaaaagac cggggacggc tgctttcggc
     2221 ccctggttca ggcgtccctg gttcaggcac ccccgctcgg gccgggagtt cagcccaccc
     2281 cggccggcgc ggcctccaga gcggcctccg cctcggccgc ccgcaggcgc tgccgctccg
     2341 cctcggccag ggcgcgggca ccgcgccccg gtgccatgtc gagccgggcc agcaccgagg
     2401 gcacggccac gctgggcatc acgtgctcat agaggatcgt ggcgcgacgt tccaggtcag
     2461 cacggttgtt gatggcctgg gacatggtgt tgatgccggc gtaagcgccg acgatcagct
     2521 ccgccgtgtc cgccgggacc acatgcggca gcacctcgcc gcgctccttg ccctcggcca
     2581 ggacgcgcgt gtggagctcc gtccaaccgt ggaaggggcc gctgcggttg aggttcgtcg
     2641 aaccgtgttc gagggtgagc cggacgctgc cgcgcaacag cgggtccacc agcagccgat
     2701 gggcgaagat catccccatg tcgaccagtt cctgcatctt ggaggcgcgg cccggctcgg
     2761 cggccggcat gtccgtcatc atctgggcat cgatcacggc gagcgccagc tcctccttgg
     2821 aggcgaagtg gaaatacagc gcccccttgg tcacttcggc ccgggccagg atctccgtaa
     2881 tggtggcggc gtcgtaaccc cgctcgtcga acaccaccgc ggccgcttcc agaatggact
     2941 ggcgagtcct gatcgcgcgg tcctgctttg ccacggtctg cctccggatc gatgagatag
     3001 ctccgccgcg tcccggcggc gagggcgaca tgtcgccggc catacgtgcc gcggtcgccc
     3061 cggaaatcaa accggcgagt acgtatccta tcaagagccg tctggcaaca tggcgcaata
     3121 cactcgatac caattcgtcc ggggcaccgc ggccggtcgc ccaactcccg tgtcacacca
     3181 tgtggaagcc gccgtccacg ggaacggtgg cgccggtgac gaaggacgag cggtcgctca
     3241 gcagccaggc cgcggcctcc gctatctcct ccggctccgc ggtgcggggc tgcggggacg
     3301 ccgcgtgcaa cgccgcctcg attcccgggt gccgttcgaa ccactccgcc accacctcgg
     3361 tgcgcgtggt gcccggggcc acggcgttca cccggatgcc gctcgccgcg tattcggcgg
     3421 ccgccgcccg ggtgaaaccg atgaccgcgt gcttggcggc cacgtacgga gcggccacgg
     3481 gagtggccaa cagcccgccc acgctgctgt tgttgacgat ggaaccaccg tcgcccgact
     3541 ccagcatggc ggcgatctcg tcccgcaggc agttccaggt gccccgggcg ttgacgtcca
     3601 tgatggcgtc gtagaggtcg tcgtccatca ggtgcagcgg agtgcgtccc gcgccccaac
     3661 ccgcgttgtt gaaagcggag tcaagtcttc cgtaacgctc cacggcgaag gcgaccgcgc
     3721 gggcggtgtc ctcgcgccgg gtcacgtcgg tgaccacgta cgccgcctcg gcccccgcct
     3781 cgcgcagctc cgcgaccagc tcgcgcagcc ggtcctcgcg ccgggccgcc agcacgacgg
     3841 tcgccccctc gcgggcgaag acccgtgcgg ccgccgcgcc gatgccactg ctggcaccgg
     3901 tgatcaaggc aatccggtcc cgcagcaatc cctggtcact cttcatcaaa ggaacccctt
     3961 cactcacgct ccggcagcgg taccgtcggg agcggcaccg tcgaccggct ccatgatgcc
     4021 ggtccgttgg gcatcgcccg gcccggtggc ggccgcccac gacgtcccgg cggcggcctc
     4081 cgcgtcgacg gtgcgcagca gcgactcgtc gatggcggcg agcgagccgg ccaggtgccg
     4141 tacgcccgcc gcccgcatca actcgccctg gtagccgtgg gcgaagccgg aggggtgccc
     4201 gatgaacgcc acgccgagct cacgtgccgt ctccgcgacc cgggccacgt cgtcgacgaa
     4261 caccgcctcg tcgaggccga gcccgaagat ctcggtggtg atctccttga cgcccggccg
     4321 gaaatcattg gtgcagacgt accgggggcc gtcgaagagg tccgcgtgcg cgccgaggtg
     4381 gcggtcgaag tgagcggcgt ccaggccgcc gtagcagacg acgcgcaggc ccagggcgcg
     4441 cagccggcgc agcagctcca cggcgccgtc gagcagccgg accgggtcgt gctccagata
     4501 cgcggcgcgc tcccggaagt agacctccag caccttctcc ggcgcccagt ccaccccggc
     4561 cgccgcgccg agcgcgcggg ccgccaccaa ctggggctgg gagaagacgg cgtactccac
     4621 gtcggcggtg taccggccgc cccggtcggt gacgaaccgg tggatcaccg ggctgaacgt
     4681 gtcattgaga aggacgccgt cgatattgac ggcggccagc cgtatccgtc gcagggactc
     4741 gaccacaatc ggcctccatt gtcgaacgaa agaacagacg gggggaacgt gccctcgaat
     4801 tacaaagcga cgcaccgcga ttgccccagg tgagagaggt aaatcacatc ggcgctgaaa
     4861 ggccgtcacc cgccttgtat cttgaccccc cgaagggcgt tgaccggggg gccgtcagcc
     4921 gctcgaggag ccctgacagc acgcaccttg acatacccgc agtcgatcct gggcgctgca
     4981 tgccgatccg agggggaacc ttgtcccaga ccacctccgc gccggcgtcc ttcgccccgg
     5041 ccctgccacg gctgaccacc accgtgccgc gcgagtacgt ccaccgcgcg gcggtcgccg
     5101 aggtcctgct cacgggctgg cgcaaggtcg aggcgaaccg gttccgggtc tgggcccaat
     5161 ggccgcgcgg ccacagtttc ttctccccgc tacggggggt gcagcacgac cccatgctgg
     5221 tcgccgagac cgtacgacag atcggttcgc tgctcgccca cgcggaattc gacgtaccac
     5281 tcggattcca gttcctgatg tggcacctgg actactcact gcgcccccgg cacacggcgc
     5341 tcgagtccac ccccgccgaa ctggtgctgg acgtcgaatg ctcggaaatc cgcaggaagg
     5401 gccggagttt cggcgggatg cggtacgacg tggtcattcg ccgggacggg gcggtcgccg
     5461 ccaccggcag cgcctcgtac acctgtacct ctccggaggt ctaccgccgg ctgcgcggcg
     5521 accggatccc cggcacaccc cccgcgctgg gcgccccggt gcgtccccgg cgcgtcggcc
     5581 ggcgctcccc gttcgacgtg gtgctcgccg aggaggacgc gcccggcgcc gcccgctggc
     5641 ggctgcgcgc cgacggccgg caccccgtcc tcttcgacca tcccgtcgac cacgtccccg
     5701 ggatggtctt actggaggcc gcccgtcagg ccgccgccgt cctctcaccg gacccggtca
     5761 tcctccccac cgaactcacc agcagcttcc accgctacgc ggagctggac agccccatct
     5821 ggatagaggc cgcccgcgag accgccgccg gggggcggaa cgggccggcc accaccgtcg
     5881 tccggggcca ccaggacgac gaactgctct tcacctgcgc gctgacctcc atacgcccgc
     5941 ggaacgcccc cgctccgccc ggcgatacgg ccgtcaaccc atccgagtag ccctgcgccg
     6001 ttttctccgg cgctccctca gccgctccat taaggtcgtc ccgccatcgg gaccgacgag
     6061 ccgagggggc gtccgcggga tgggcctgag tctcaccagc accgcgttcc tcgttctgct
     6121 gatcgtcgcg tcggtgctcg ccgtggtcgc cacgctgctg ctgtgggcgc gggtccccgg
     6181 gcccgcaccg ctgcgctggc tgggccgggt gctgttgatc ggcctctgcc aggcgaccgc
     6241 gatctgcgtg gtcgccgtct cgatcaactc cagctacggc ctctacgcct cctgggacga
     6301 cctcttcggc cgcaagagca ccgggcccgt ctcgatgccc ggcccgcccg cccaccgcgc
     6361 ccgcttcagc caggccgact acggcatgca ggagacgtac ttccggggct cgcgctccca
     6421 gctctccggc caggtcctgg tgtggacgcc gccgcagtac gagcaggcgc gctaccgccg
     6481 gaccgccttc ccggtggtcg tcctgctgca cggggtgccc ggctccccgc agtcctggat
     6541 ggagctgggc cggatgccgg gcgcctacga gcggctgctg agggagggcg cgacccgccc
     6601 gttcatcctg gccgtgccga tcatcaaccc cggcggcgtg gacaccgact gctccgacgt
     6661 gcccggccgc aaggtggcga cctggctgtc ggaggacgtg cccgagctgc tgcgcaccca
     6721 cttccgcacg ggccggggcc cggagtcctg gggcgtgctg ggcatctcga ccggcggcta
     6781 ctgcgcggcc aagctgccgc tgcagtaccc ccgggcgtac gcggcgggcg cggccctgga
     6841 cccggacccg ctcaacggcg acggcggcgc gatccccgac cccgggctgc ggaaacgcaa
     6901 cagcccgacg tggctggtgc ggcacaccga cgccgacgtc gggctgttcg tggcgacgtc
     6961 ccggcaggac cgggacagcc cgccgcgcta tgtcgaggag ttccagcggg aggcggcggg
     7021 cggcaaggtc cggctgagga cgatgctgct gccgtccggg ggccacaact acggcacctg
     7081 gatcaacctc tacccggcgg ccttctcctg gatgagcggg cagctgcggg gcggacccgg
     7141 ctgacgccgg gtcctgagga cggccgaagt cggccggtgt ccgcggcacg accctgctgg
     7201 gcgggcggct tcgcgagccg cgcacaggcc gaggcggtta ttccgccgcc tcgggccgct
     7261 ccgagggctt gtcctcctcg gaaggcttcg gggcctccga gggcttgacg tcctccgagg
     7321 gcttggcctc ctgcgagggc ttcggggcct gcgaaggctc cggcgtcccg gacggcttcc
     7381 cgccatccct cggcttgggc ttgtcggccg tgtcctgcgg gaacgtcagc tgctggctca
     7441 tccactccag caccggtccg atctcccgcc gccacgtcgt gaagtggtgg ctgccctcgg
     7501 ggaggatgat cgaggaggcg gtcatcggct gcttgacggc ccccaggaac ttctcggtct
     7561 ccgcgtagtt cttctcgccc ttcttgctgc tggtcaccag cacgttcacc cggggcacgg
     7621 gcatgtttcc cagccgccag atcaggtcgt gctcctgctg cttgcgcttg gcgtccgggc
     7681 cggagccgaa gagattgccg gtggtgaggt cgttgccgac cttgtagtcg ccggagagcg
     7741 cggcggcggc ggggtagacg tcgggctgcc gcatcgcgag ctccagcgcg caggtgccgc
     7801 ccgaggagta gccgaggacg ccccaggcgc tcgggtcgtg gccgacgcgg taggtggtct
     7861 tgagcgcgtc gggcaggtcc ttggtgaaga acgtctccgc ctgcgggccg tcgggcacgt
     7921 ccacgcactc ggtgtcgcgc ggcggggcga tcgtcggccg gagcatcacg atgacggtcg
     7981 gctgcatctt gttctccttc agcagcgacc ccgccgtctg cggcacctgg aggtgctggg
     8041 ccaaattcat gatcccgccg ggataaccgc tgatcacgac catgacggga aagcggtgac
     8101 gctcgtactg cttctggaag tactgcggcg ggagatagac gaatgccgga ttgatggccc
     8161 gcgagcgctg tccgacgata cggaccgact ggaccttccc ctccttgtcg gcgggaccgc
     8221 gcggaattcc gcccaccttg tcgagcccct gcggcccggc gggctgcacg agcccgtcct
     8281 tcgacgcgcc gaccgtcgcg tacgggccgt tccggcccat ctcgttcaca ttgaccgggg
     8341 ccttgtcgac ccgcccgagg agctgattcc aggtcccgta gaagccgccc caggaattca
     8401 cggccagcgc cagcgacgcc atgatcgtca gctgggtggt cgcgatgacc cccagccgtc
     8461 ccagcaccgg ccggaccccg cggccggcca gccggggcca gatccagacg gtgagcccca
     8521 cgcacaacac ggcggcgaat accaccgtgt acaagagtga cctgctggtc aggcccatgc
     8581 gcctctcaac tccctgcccc cgtggtgggt actcatgttc ggtccggtaa tactcacgga
     8641 taaagaggcc ggaacaggcg gagagggttg ccctgacctc atttattgcc ctgctcttgc
     8701 cctgcccttg tcctgggctt ccccgggcgt tcccgagaac gaaaggcccc ttcgggcggt
     8761 tacccgcgcc cggtgaagac ggatcgacgg tcggatggag actggccgaa cgcctccttc
     8821 cgctgtttgg tggaatcacg gccgagcgac gggggcaccg cccgggggcg gcggagaccg
     8881 ggccggtgga ggtgggacgg catgaaccgg aatccggacg ccgaggtgcg caacccgtac
     8941 ctcggggggc tctacgcccc cgtgacggac gagacgaccg cctacgacct gcccgtgacc
     9001 ggccggctgc ccgagtcgct gcgcggccgc tatctgcgca acggccccaa ccccgtgcac
     9061 gtcgacgatc cggccggcta ccactggttc ggcggcgacg gcatgatcca cggcgtccgg
     9121 ctgcgcgacg gccgcgccga gtggtaccgc aaccgctggg tgcgctccga cgccgtcgcc
     9181 gggcggctcg gcgagaagct gctgcacggg cggcgccacc ggggcctgga cttcgcgccc
     9241 aacacccacg tgcagtcctt cgccgggcac tgcctggccc tggtcgaggg cggggcgctc
     9301 ccctacgagc tcgatcccga gctccatacg atcggcccgt tcgacttcca cggcaccctg
     9361 ccgggcggct tctccgccca cccggtgacc gacccgcacg acggcgagct gcacgcggtg
     9421 gcgtactgcc cggcctggcc gtatgtgcag tacgtcgtcg ccgggcggaa cggctgtgtg
     9481 cgccggcacg tcgagatccc cgtcgcgggc tccccgatga tgcacgcctt ctcgctcacc
     9541 gagcggtacg tgctgctgta cgacctgccg gtggtcttcg ggcgggaccc gcgcgacggt
     9601 ggcgcccatc cgcgctgggt gccggaccgg ccggcccggc tcgggctcct gccgcgcgac
     9661 ggcggggcgg cggagacgcg ctggctggag accgagccgt gcttcgtctt ccaccccatg
     9721 aacgcgtacc agcgcgacga cggccggatc accgtccatc tcgccgtcta cgaccggtac
     9781 ttcgaccgtc gtcggccgct gcccggcgac cacctcgccc ggctggagcg ctggaccgtc
     9841 gaccccgtcg cgggcaccgt gcgccgactc ccgctggacg accggccggt ggagtacccc
     9901 cgcgtcgacc cccggcggct caccgtccgc caccgcttcg gctacgtcat gcgcgagcgg
     9961 gtggcgggac gggacaccgc gctcatcaaa tacgacctgg agcgcggcac gagcgaggag
    10021 ttcgaggtgc cggcgggcgg cgacgtgggc gagggcgtgt tcgtcccggc cgcgcccggg
    10081 gcggcggagg acgagggatg ggtgctggcg tacgcgtacg acccggcgcg cggggcaggc
    10141 gaactggtgg tcctggcggc ccaggacttc gcggccggtc ccgtggcccg ggtgcacctc
    10201 ccgggccggg tgccgttggg cttccacggg agctggatcc cggactgccc atgacacgta
    10261 ccacggcgtg tcgggtgtga acgtactgga ccggacttga cagctagcct tacgtagtcg
    10321 tcaagcatgc ggacttttac gagcagtacg gacatatatc tcccctctcc ggcatcactc
    10381 gcacccgaga cacacgacct gagacacacg aagggcatct ccccatgggc attcggagtc
    10441 tgctgcggaa cgcgttcggc cgcgccaagg cccccggacg cgacgaaccg agcctccccc
    10501 agcagaacgc gggccccgac cacaccgcga acccggtgtc cgtcccggcc cagccgaccg
    10561 ccgagaccgc cgaccgcgcc ggctcgaccg ttcccgaccc cggcccgctc gggcccatcc
    10621 ccaccccggg ccccgcccgg cccgagccga tccccgagcc ggagccgtcg ccgacgccga
    10681 tgccgaagcc caagcccgtc cccgagccgg acccgacgcc ccggccggac ccccaccccg
    10741 tgcccgaacc gccccccggc ccggacccgg agcccgcgcc cgcgatgacg gcggaggcgc
    10801 cggtgctgac ggcggaggcg gccgtgctga cggcggaggc tcccgccatg acggcggaga
    10861 cggcggccgt gagcctcacg aaggttcagg agaccgcgcc cggcctcgtc agcctctaca
    10921 agtcggcggg cgtctcgctg cggaagcagg gcctggcggg ccaacgggcg gcggtctacc
    10981 tcgtcctgga
//
