LOCUS       NZ_CP034587            10408 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   NZ_CP034587
VERSION     NZ_CP034587.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2018) School of Life Sciences, Ludong University,
            186 Hongqi Road, Zhifu Distric, Yantai, Shandong 264025, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 247.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003970715.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:34:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,575
            CDSs (total)                      :: 6,474
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 104 of 198
            Pseudo Genes (incomplete)         :: 118 of 198
            Pseudo Genes (internal stop)      :: 12 of 198
            Pseudo Genes (multiple problems)  :: 30 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:02:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2507911
            Orig. end                         :: 2518319
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034587.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10408
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="17"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10408
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10408
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5408](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5408
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            534..1493
                     /locus_tag="EKH77_RS10755"
                     /old_locus_tag="EKH77_10755"
     CDS             534..1493
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060736.1"
                     /locus_tag="EKH77_RS10755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10755"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_126914180.1"
                     /transl_table=11
                     /translation="MAHLATAPGPRRRRARERLRVLGFLSPWLIGFTVFFGYPLTATVY
                     FSFTRYNQIQPPSFVGLRNWRYVFTQMPLFGPALWNTLWLVVVMVALRVVFGLGTGLLV
                     TKVKTGAGFFRTAFYLPYLAPPVAATVAFVFLLNPGTGPVNDALTALGVPAPDWFNDPH
                     WAKPSLVLLSLWGIGDLMVIFLAALLDVPKERYEAAQLDGAGPIATFRYVTWPAITPVV
                     MFAVVTGVVQTMQYYTQALVAGKLASGVSVGPGTTVQPGYPDHSTLTVTQLVYSLGFQN
                     FNTGAACVLSLVLFAIAMAAASLLMRGRAGLLGAEDRP"
     gene            1511..2341
                     /locus_tag="EKH77_RS10760"
                     /old_locus_tag="EKH77_10760"
     CDS             1511..2341
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643166.1"
                     /locus_tag="EKH77_RS10760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10760"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_240667305.1"
                     /transl_table=11
                     /translation="MRRGRVLHWIAVHTLAVAAALFFTLPFVFVLLTSVMSDDQALSGE
                     LWPRSWHWSNYAEVFRTPGFLTWWRNSLLYAGLGTLFTVCSSLPVAYALARFRFRGRRT
                     ALVLVIATMTLPPQVVVIPMYLVWAQQLHLSGTLWPLIVPLAFGDAYSIFLLRQFLLTI
                     PAEYLEAARLDGCGELRTLLRVVAPMAKPGIAAVALFQFFACWNDYFGPQIYAAQNPGA
                     WTLSYGLESFKSAHSVNWNLTMAATLLVMAPVIAVFFFAQKAFVEGVTLTGVKG"
     gene            2338..3591
                     /locus_tag="EKH77_RS10765"
                     /old_locus_tag="EKH77_10765"
     CDS             2338..3591
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179641.1"
                     /locus_tag="EKH77_RS10765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10765"
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_126914182.1"
                     /transl_table=11
                     /translation="MKLAVVGGGSTYTPELVDGFARLRDVLAVEELVLVDPAAERLEPV
                     GRLARRILAAQGHPGRVTWTDDLDAAVDGADAVLLQLRVGGQAARERDETWPLECGCVG
                     QETTGAGGLAKALRTVPVVLDIAERVRRRNPGAWIVDFTNPVGIVTRALLTAGHRAVGL
                     CNVAIGFQRKFAALLGVAPGEVELDHVGLNHLTWERAVRVGGRDVLPGLLAEHGDAIAA
                     DLRMPRRLLDRLGVVPSYYLRYFYEHDAVVEELRKKPSRAAEVAEMERTLLEMYADPAL
                     DHKPELLAKRGGAFYSEAAVALTSSLLTGTGPVQVVNTLNNGTLPFLPDDAVVEVPAAV
                     DAAGARPLPVRPLEPLFAGLVAHVTAYEHLALEAALKGGRDRVFAALLAHPLVGQADRA
                     EKLTDALLHHNREHLAWA"
     gene            3582..4586
                     /locus_tag="EKH77_RS10770"
                     /old_locus_tag="EKH77_10770"
     CDS             3582..4586
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045974.1"
                     /locus_tag="EKH77_RS10770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10770"
                     /product="BadF/BadG/BcrA/BcrD ATPase family protein"
                     /protein_id="WP_126914183.1"
                     /transl_table=11
                     /translation="MGVIVAIDAGNSKTDVVVTGTDGTVFGRARGGGFRPHAVGVEQAV
                     DTLQSAVAEAMSDAAAELALPLDVRLFSACLANADFPVEEAELAEAIARRNRAAGDPAG
                     YPPVRVANDTFALLRAGLSDEGEPAGVAVVCGAGINCSGLAPGGRVARFAAVGRISGDW
                     GGGAHLAEEAVWWAARAADGRGEATALARELPAHFGLSTMPELIEALHLGRIERARRHE
                     LAPVLFAVAAAGDAVAGAIVARQADEVVALASAALDRLGLLDAAVPVVLGGGVLAARHP
                     LLHERVMRGLAGRAPLAVPRVVTAPPVLGAALLALDHLGAPTAAYARLREHFA"
     misc_feature    4655..4672
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.39"
                     /tool="antismash"
     misc_feature    4658..4673
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.89"
                     /tool="antismash"
     misc_feature    complement(4676..4691)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     misc_feature    4773..4787
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.79"
                     /tool="antismash"
     gene            5001..5408
                     /locus_tag="EKH77_RS10775"
                     /old_locus_tag="EKH77_10775"
     CDS             5001..5408
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018091618.1"
                     /locus_tag="EKH77_RS10775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10775"
                     /product="tyrosinase cofactor"
                     /protein_id="WP_126914184.1"
                     /sec_met_domain="melC (E-value: 2.6e-45, bitscore: 152.6,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKNVTRRVVLRGTAIAVAGAALAAPAAMAATRAALPMDHTGMDH
                     SGHGSHGPQPFDEVYQGRRIVGTPVTTGHEAHHGGFAVTIDGKELHVMRNADGTWISVI
                     NHYQTYPDPLALTRAAVDKLQGASLVPITTR"
     gene            5477..6298
                     /locus_tag="EKH77_RS10780"
                     /old_locus_tag="EKH77_10780"
     CDS             5477..6298
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_030787646.1"
                     /locus_tag="EKH77_RS10780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10780"
                     /product="tyrosinase family protein"
                     /protein_id="WP_126914185.1"
                     /transl_table=11
                     /translation="MAVRKNQATLTATEKRNFVNALLALKKSGKYDEFVRTHNEFIMSD
                     GDDTDRVGHRSPSFLPWHRRFLIQFEQELQRIDSSVTLPYWDWTADRTVTASIFAADFL
                     GGNGRSRDAQVTTGPFAYSTGQWNINVSADDRPYLQREMGASVRALPTRAEVDSVLAMA
                     TYDMAPWNSASDGFRNHLEGWRGVNLHNRVHVWMGGQMATGVSPNDPVFWLHHCFIDKL
                     WADWQRMHPTSGYLPTGGTTNVVDLKDTMRPWNNVTPADMLDHTKFYTYDR"
     gene            6594..7979
                     /locus_tag="EKH77_RS10785"
                     /old_locus_tag="EKH77_10785"
     CDS             6594..7979
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006605589.1"
                     /locus_tag="EKH77_RS10785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10785"
                     /product="hypothetical protein"
                     /protein_id="WP_206279839.1"
                     /transl_table=11
                     /translation="MSPAQPDPGTRRTAWREGLERIADAATTEPGRLRVIGAVLAALLV
                     AFGAVTAWQVTDRSSAADAVIDRSQPLSADAADIYRSLADADTAAAAGFLAGRDEPRTV
                     RRRYEKDIGVASELLVKAAADTGGSSSAREQIARLNQQLPVYTGLVESARAAGRQGLPL
                     GGAYLRYASDRMREDLLPAARALYEAETGRLRSDYADAKSWPWTALTTGVVALGALGWA
                     QRRAFLRTNRVFNHGLLAGTAAGAVVLLWLTVGHAVARADLTDSYENGAKSLQVLSEAR
                     IASLQARGDESLTLVARGAVLTASGDDAYEASYRTGMRKLIGGDVTASGEPAPDSLLGR
                     ARSLADGSEGRDPVLEAIHDVKQWQQRHGEARTADVGGYYGQALAKVIGEKGSARGSTG
                     ESFDQVDTALRQALTHEEDDFRRAAEDGRGAFTGLAAGAAVLAVLGAAGAVLGIGRRLS
                     EYR"
     gene            7997..8962
                     /locus_tag="EKH77_RS10790"
                     /old_locus_tag="EKH77_10790"
     CDS             7997..8962
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091: glutamine-binding lipoprotein glnH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538917.1"
                     /locus_tag="EKH77_RS10790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10790"
                     /product="glutamate ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_126914186.1"
                     /transl_table=11
                     /translation="MGGRRGTRAGAVVTACVWTLAVALGAAVLPAARPTGPVARIPAAA
                     PAAAVRAPATCVAPEASLRPSTADGPAVRRIKERGRLIAGVDQNSYRWGYRDPATGELS
                     GFDIDLVHAIAKAVLGDPGKVVFLAIPTNQRIPALEKGKVDIIARTMTINCDRARQVAF
                     STAYFEAGQQVLAPKASPVTAFDDTLEGKKVCTAKGSTGESELKNESHGASVLTVPNQL
                     DCLVRLQLGQVDAVITDSALAAGQAAQDPSVRLVGKPFTTESYGVAMNLKDEDLVRRVN
                     AVLEDYRRGGEASPWMLAYRKWLAADLQGITAPPEPRYRD"
     gene            9032..10354
                     /locus_tag="EKH77_RS10795"
                     /old_locus_tag="EKH77_10795"
     CDS             9032..10354
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950105.1"
                     /locus_tag="EKH77_RS10795"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_10795"
                     /product="hypothetical protein"
                     /protein_id="WP_126914187.1"
                     /transl_table=11
                     /translation="MVVAGPTGPALSREEVDRALARLGAEHEAVESTLLALQDHAGRRL
                     LEGAELTGVTRSRWESTELLITQLWVYFDAYTDALEAARELRGRRRWPTSGELSELTDL
                     LRGTAVTLPAGPPQAGMVTLGVAARLSERLSLTELVERMNSWYAQALDVLVIADAVWSA
                     LPTRIDLLAAELGRVRSLAHSVGVLPGEHPAGDDLERLTMELAALRSEVISDPLVFWTG
                     APPSSAPGGRPDTARYDRAERALEDVRREVEAVLDVRQDAERRLMRVRDVLSRADRTLG
                     EARRARMEVLSKIAAYEVPVVSGPPTVLYEQLETAGEYRRRAAWHRLSPLLEGLERHAE
                     EELLRARESLTAVTAPLAVRAELRGRLDAYKAKAARLGLAEDGLVMERYDVARRMLWSA
                     PCDLVAAEQAVLRYQRAVAGAPAPRGSAASEPTGTGGTHDR"
ORIGIN
        1 caaggagacc ggcacggact tccgctgggg cacggccccg ctgcccgtac ccgacgacca
       61 ggccgacgcc tacgggcgcg gctgcctcac cggcacggtc gtcggcatcg cccacagcag
      121 ccggcaccag aacgcggcct gggagctggt gcgattcctg acgaccgaca ccgatcaggt
      181 cgtcgccttc gcgaacgcca tccacaacgt gccctccacc aaggcggcgc tcgcctcccc
      241 cgcgctcgac gccgaccccg ccttccgcac cttcgtcggc atcgccggcg acccccacag
      301 cgtctccgtg ccgccctcgg ccaacggcgg gatgtacatc ctcgccctgc gcgacttcgc
      361 ctacgacagc gaggcgggcc gggtccccga cctggaccgg gggctgcgcc gcctcgaccg
      421 gcggatcgac gacgacaccc gccagaccgc cggctgacca ccggaccgcc ggccgaccac
      481 cggaccgccg gccgacccgc ccacgccgcc cgccacccga cgaaggccct gtcatggcac
      541 acctcgccac cgcccccggc ccacgccgcc gacgcgcccg ggaacgcctg cgcgtcctcg
      601 gcttcctctc cccctggctg atcggcttca ccgtcttctt cggctatccg ctgaccgcca
      661 ccgtctactt ctccttcacg cgctacaacc agatccagcc cccgtccttc gtggggctgc
      721 gcaactggag gtacgtgttc acacagatgc cgctgttcgg gccggcgctg tggaacacgc
      781 tgtggctggt cgtggtcatg gtggccctgc gcgtcgtctt cgggctgggc accgggctgc
      841 tggtcaccaa ggtgaagacg ggcgcgggct tcttccgcac cgccttctac ctgccctacc
      901 tcgccccgcc cgtggccgcg acggtggcct tcgtcttcct cctcaacccg ggcaccggcc
      961 cggtgaacga cgccctcacg gccctcggcg tccccgcccc cgactggttc aacgaccctc
     1021 actgggccaa gccctcgctg gtgctgctgt cgctgtgggg catcggcgac ctgatggtca
     1081 tcttcctggc cgccctgctg gacgtgccca aggagcggta cgaggccgcc cagctcgacg
     1141 gcgccgggcc catcgcgacg ttccgctatg tcacctggcc ggcgatcacc ccggtggtga
     1201 tgttcgcggt cgtgacggga gtcgtgcaga cgatgcagta ctacacccag gcgctcgtcg
     1261 ccgggaagct cgcctccggc gtcagcgtcg gccccggcac gaccgtccag cccggctatc
     1321 cggaccactc cacgctcacc gtgacccagc tcgtctactc gctcggcttc cagaacttca
     1381 acaccggcgc cgcgtgcgtg ctctccctgg tgctgttcgc catcgccatg gccgccgcct
     1441 cgctgctgat gcgcggccgc gccgggctgc tcggggcgga ggaccggcca tgagaacgag
     1501 gaccaggccc atgagaagag gacgcgtcct ccactggatc gccgtgcaca ctctcgccgt
     1561 cgccgcggcg ctcttcttca ccctgccgtt cgtcttcgtc ctcctcacct ccgtgatgag
     1621 cgacgaccag gccctgagcg gcgagctgtg gccgcgttcc tggcactggt ccaactacgc
     1681 ggaggtcttc cgcacccccg gcttcctcac ctggtggcgg aactcgctgc tgtacgccgg
     1741 tctgggcacc ctgttcaccg tgtgctcctc cctcccggtc gcctacgcgc tcgcgcggtt
     1801 ccgcttccgg ggccggcgga ccgcgctcgt cctcgtgatc gccacgatga cgctgccgcc
     1861 gcaggtcgtc gtcatcccca tgtacctggt gtgggcccag caactgcacc tgtcgggaac
     1921 actgtggccg ctgatcgtgc cgctggcgtt cggcgacgcg tactcgatct tcctgctgcg
     1981 gcagttcctg ctcaccatcc ccgccgagta cctggaggcc gcgcgactgg acggctgcgg
     2041 cgagctgcgc accctgctgc gcgtcgtcgc gccgatggcg aagccgggca tcgcggcggt
     2101 cgcgctgttt cagttcttcg cctgctggaa cgattatttc gggccgcaga tctacgccgc
     2161 ccagaacccg ggcgcctgga cgctgagtta cggcctggag tccttcaaga gcgcccacag
     2221 cgtcaactgg aatctgacga tggccgccac cctgctggtc atggcgccgg tcatcgccgt
     2281 cttcttcttc gcccagaagg ccttcgtcga aggcgtcaca ctgacaggag tcaagggttg
     2341 aagctcgcag tagtgggtgg cggctccacc tacacccccg aactcgtcga cggattcgca
     2401 cggctgcgcg acgtcctcgc cgtcgaggag ctcgtcctcg tcgaccccgc cgccgagcgg
     2461 ctggaaccgg tcggccgcct ggcgcggcgc atcctcgccg cgcagggcca cccgggccgg
     2521 gtcacctgga ccgacgacct cgacgcggcc gtcgacggcg ccgacgccgt gctgctccag
     2581 ctgcgcgtcg gcggccaggc ggcccgcgag cgggacgaga cgtggccgct ggagtgcggc
     2641 tgcgtgggac aggagaccac gggcgcgggc ggcctcgcca aggcgctgcg gacggtcccg
     2701 gtggtcctcg acatcgccga gcgggtgcgc cgccgcaacc ccggcgcctg gatcgtggac
     2761 ttcaccaacc ccgtcggaat cgtcacccgc gccctgctga ccgccgggca ccgcgctgtc
     2821 gggctgtgca acgtggccat cggtttccag cggaagttcg ccgccctgct cggggtggcg
     2881 cccggcgagg tcgagctgga ccacgtcggc ctgaaccacc tcacctggga gcgggcggtg
     2941 cgcgtcggcg gccgggacgt cctgcccggg ctgctcgcgg agcacggcga cgcgatcgcg
     3001 gcggacctgc ggatgccgcg ccggctgctg gaccggctgg gcgtcgtccc ctcgtactac
     3061 ctgcgctact tctacgagca cgacgcggtc gtcgaggagc tgcggaagaa gccctcgcgg
     3121 gcggccgagg tcgcggagat ggagcggacg ttgttggaga tgtacgccga cccggcgctg
     3181 gaccacaagc cggagctgct ggccaagcgc ggcggggcgt tctactccga ggccgccgtg
     3241 gcgctcacct cgtcgctgct gaccggcacc gggcccgtcc aggtggtcaa caccctcaac
     3301 aacggcacgc tgcccttcct ccccgacgac gccgtcgtcg aggtgccggc ggcggtggac
     3361 gcggccgggg cgcgccccct gcccgtccgg ccgctggagc cgctgttcgc cgggctcgtc
     3421 gcgcatgtga cggcctatga gcacctggcg ctggaggcgg ccctcaaggg cggccgggac
     3481 cgggtcttcg cggcgctcct cgcccacccg ctcgtcggcc aggccgaccg ggcggagaag
     3541 ctgacggacg ccctcctcca ccacaaccgg gagcacctgg cgtgggcgtg atcgtggcga
     3601 tcgacgccgg caacagtaag accgacgtgg ttgtcaccgg tacggacggc acggtgttcg
     3661 gccgggcgcg gggcgggggc ttccggccgc acgcggtggg cgtcgagcag gccgtggaca
     3721 ccctccagtc ggccgtcgcc gaggcgatgt ccgacgcggc ggcggagctc gcccttccac
     3781 tggacgtccg cctcttctcg gcctgtctcg ccaacgccga cttcccggtg gaggaggcgg
     3841 agctggcgga ggcgatcgcc cggcggaacc gggcggcggg cgacccggcg gggtatcccc
     3901 ccgtccgggt cgccaacgac accttcgcgc tgctgcgcgc ggggctgtcc gacgagggcg
     3961 agccggcggg cgtcgccgtc gtgtgcgggg cgggcatcaa ctgctcgggg ctggcgcccg
     4021 ggggccgggt cgcccgcttc gccgccgtcg ggcggatctc gggcgactgg ggcggcgggg
     4081 cgcacctggc cgaggaggcg gtgtggtggg cggcgcgggc ggcggacggg cgcggcgagg
     4141 cgacggcgct ggcgcgggaa ctccccgccc acttcgggct gtcgacgatg ccggagctga
     4201 tcgaggccct ccatctgggg cggatcgagc gggcgcggcg gcacgaactg gcgccggtgc
     4261 tcttcgcggt ggccgccgcc ggtgacgcgg tggccggggc gatcgtggcg cggcaggccg
     4321 acgaggtggt cgccctggcc tcggcggccc tggaccggct ggggctgctc gacgcggcgg
     4381 tgccggtggt gctgggcggc ggggtcctgg cggcccgtca cccgctgctc cacgagcgcg
     4441 tcatgcgggg gctggcggga cgggcgcccc tggccgtgcc ccgtgtggtg accgcgccgc
     4501 ccgtgctggg ggcggcgctg ctggccctgg accacctcgg ggcgcccacc gccgcgtacg
     4561 cgcggctgcg ggagcacttc gcgtagcgcg cgagatcggc ggaaaccgcg ccgtggactc
     4621 cggccttccc ggccggagtc cacggcgcgg cgccatgttc gcgtcatgtt cacgccgtga
     4681 gagacgtcac cggcggaggc ggtccgccgt aaatccttcg cgcgggatca ccccggggcg
     4741 gcggacttcc tgacacccgc gtcaatagcg ggattggcca gaaattcctc ccctaccgct
     4801 ggttgaccat tcatataccc aatgtccgta ttcgggtcaa ccatttcccc ctctcttcaa
     4861 gatcgtgcaa acatccggcc acgcatggat tgatcacgaa atacgacaaa gaactgccgc
     4921 aactcgcccc aaaagggcgt tgccgagcat tcgtgacagc ccctgctccc gacccacaga
     4981 tcccgagggg ggatacacgt atgtcgaaga acgtcacccg ccgcgtcgtc ctgcgcggca
     5041 ccgcgatagc cgtcgccgga gcggccctcg ccgctccggc cgccatggcg gcgacgcgcg
     5101 ccgccctgcc catggaccac acgggcatgg accactccgg tcacggctcc cacggccccc
     5161 agcccttcga cgaggtctac cagggccggc gcatcgtcgg cacgcccgtc acgaccggcc
     5221 acgaggccca ccacggcggc ttcgccgtga cgatcgacgg caaggaactg cacgtcatgc
     5281 ggaacgcgga cggtacgtgg atcagcgtga tcaaccacta ccagacgtat cccgacccgc
     5341 tggcgctgac gcgtgccgcc gtcgacaagc tccagggcgc ctcgctcgtc ccgatcacca
     5401 cccgctgacc ccggccgact gccgaccgtc cggcccgacg cggccggtcc cccgaaccga
     5461 gaggacgtag acccccatgg cagtgcgcaa gaaccaggcg accctgacgg ccacggagaa
     5521 gcgcaacttc gtcaacgccc tgctggcgct gaagaagagc ggcaagtacg acgaattcgt
     5581 gcgtacgcac aacgagttca tcatgagcga cggcgacgac accgaccgcg tcggccaccg
     5641 ttcgccgtcc ttcctgccct ggcaccgccg cttcctcatc cagttcgagc aggagctcca
     5701 gagaatcgat tcctcggtga cgctcccgta ctgggactgg accgccgacc gcaccgtcac
     5761 ggcctccata ttcgccgccg acttcctcgg cgggaacggc cgcagccgcg acgcgcaggt
     5821 caccaccggc ccgttcgcgt actccaccgg ccagtggaac atcaacgtct cggccgacga
     5881 ccgcccctac ctccagcggg agatgggcgc gagcgtccgc gcgctgccca cccgcgccga
     5941 ggtcgactcc gtgctcgcca tggccaccta tgacatggcc ccctggaaca gcgcctccga
     6001 cggcttccgc aaccacctcg agggctggcg cggcgtcaac ctccacaacc gcgtccacgt
     6061 gtggatgggc ggccagatgg ccaccggcgt ctcccccaac gacccggtgt tctggctgca
     6121 ccactgcttc atcgacaagc tgtgggccga ctggcagcgc atgcacccca cctcgggcta
     6181 cctgccgacc ggcggcacca ccaacgtcgt ggacctcaag gacacgatgc gcccgtggaa
     6241 caacgtgacc ccggccgaca tgctcgacca cacgaagttc tatacgtacg accgctgacg
     6301 gccactccgc tcgtggggca cgcgccgcga gacgccgggg gtgacgggca cgaccgcccg
     6361 tcacccccgg cgttcccgtt tccgggtact ccgtccgcac gggaaccgaa cagacgcccc
     6421 acgcgtgaaa tggggtgaaa ggccgaaacg gacacccggg cgacgctcac gacccgtgca
     6481 agatcgatgc acaaccggtg tgtttgtcag tccctgcggc catactgctg gcctggcacc
     6541 cgttccccgc cgcccggggg acagcgggcc gcggcgaccg agggggaggt cacgtgtcac
     6601 cagcgcagcc ggatccggga acgcggcgca ccgcgtggcg cgaggggctg gagcggatcg
     6661 cggacgcggc cacgacggag cccggcagac tcagggtcat cggcgcggtc ctggccgcgt
     6721 tgctggtcgc cttcggcgcc gtcaccgcct ggcaggtcac cgaccggtcg tcggcggcgg
     6781 acgccgtgat cgaccgcagc cagccactga gcgccgacgc cgccgacatc taccgctccc
     6841 tggccgacgc cgacacggcg gccgccgccg gcttcctggc cggccgggac gagccccgca
     6901 cggtccgccg gcgctacgag aaggacatcg gcgtcgcctc cgagctcctg gtgaaggccg
     6961 ccgccgacac cgggggctcc agctcggccc gcgagcagat agcccggctc aatcagcaac
     7021 tccccgtcta caccgggctg gtggagtccg cccgcgcggc gggccggcag ggcctgccgc
     7081 tgggcggcgc ctatctgcgc tacgccagcg accggatgcg cgaggacctg ctgccggccg
     7141 cccgcgccct ctacgaggcc gagaccggac gcctccgttc cgactacgcg gacgccaagt
     7201 cctggccctg gacggccctc accacgggcg tcgtggccct cggcgccctc ggctgggccc
     7261 agcgtcgcgc cttcctgcgc accaaccggg tgttcaacca cggcctcctc gccgggaccg
     7321 ccgccggcgc ggtggtcctg ctgtggctga ccgtcggcca cgccgtggcc cgcgcggacc
     7381 tgaccgactc ctacgagaac ggggccaagt ccctccaggt gctcagcgag gcccggatcg
     7441 cctcgctcca ggcccggggc gacgagagcc tcaccctggt ggcccggggc gccgtgctca
     7501 ccgcgtcggg cgacgacgcc tacgaggcca gctaccgcac gggcatgcgc aagctgatcg
     7561 gcggcgacgt caccgcctcc ggcgagcccg cccccgacag cctgctcggc cgggcccgct
     7621 ccctcgcgga cggctcggaa gggcgcgatc cggtgctgga ggcgatccat gacgtcaagc
     7681 agtggcagca gcggcacggc gaggcccgca ccgccgacgt cggcgggtac tacggccagg
     7741 cgctcgccaa ggtgatcggg gagaagggca gcgcccgggg cagcaccggc gaatcgttcg
     7801 accaggtgga caccgcgctg cgccaggccc tcacccacga ggaggacgac ttccgccggg
     7861 cggcggagga cgggcgcggc gcgttcacgg ggctggcggc cggagccgcc gtcctggccg
     7921 tgctcggggc cgcgggcgcg gtgctcggca tcggccgcag gctgtcggag taccggtgag
     7981 acggggaggc ggagcgatgg gcggacgacg cggaaccagg gccggggccg tggtgacggc
     8041 ctgcgtgtgg acgctcgccg tcgccctggg cgcggccgtc ctgccggcgg cgcgccccac
     8101 cggccccgtg gcccggatcc cggcggccgc gccggcggcg gccgtgcgcg cgcccgcgac
     8161 gtgcgtcgcc cccgaggcga gcctgcggcc ctcgacggcc gacggcccgg ccgtccggcg
     8221 catcaaggag cgcggccggc tcatcgccgg cgtcgaccag aacagctacc gctggggcta
     8281 ccgcgacccc gccaccggcg agctcagcgg cttcgacatc gacctggtcc acgccatcgc
     8341 caaggccgtc ctcggcgacc ccggcaaggt cgtcttcctg gcgatcccca ccaaccagcg
     8401 catacccgcc ctggaaaagg gcaaggtgga catcatcgcg cgcaccatga cgatcaactg
     8461 cgaccgggcc cggcaagtcg ccttctccac ggcctacttc gaggccggac agcaggtgct
     8521 ggcccccaag gcctcaccgg tcacggcgtt cgacgacacc ctggagggga agaaagtctg
     8581 tacggccaag ggatccacgg gcgagagcga gctgaagaac gagtcgcacg gcgcgtccgt
     8641 gctgaccgtc cccaaccagc tcgactgcct ggtccggctc cagctcggac aggtcgacgc
     8701 ggtgatcacc gacagcgccc tggccgccgg acaggcggcc caggacccgt ccgtgcgact
     8761 ggtcggcaaa ccgttcacca ccgagtccta cggcgtggcg atgaacctca aggacgaaga
     8821 cctggtacgc cgggtcaacg cggtactgga ggactaccgc cggggcggcg aggcgagccc
     8881 ctggatgctg gcgtaccgca agtggctggc ggccgacctc cagggcatca ccgctccgcc
     8941 ggagccccgg taccgggact gacggcacgg aaggaccgaa gcaccacacc gttcgcgcgc
     9001 ggcaccggcc gcgggacagg agaggggacc gatggtggtc gcggggccca ccgggccggc
     9061 cttgagccgc gaggaggtgg accgtgcgct ggcacggctc ggcgcggagc acgaggcggt
     9121 cgagtccacc ctgctcgccc tccaggacca cgccgggcgg cggctgctgg agggcgcgga
     9181 gctgaccggc gtcaccagga gccggtggga gtccaccgag ctcctcatca cccagctgtg
     9241 ggtgtacttc gacgcctaca ccgacgccct ggaggcggcg cgtgagctgc gcggccgccg
     9301 ccgctggccc acctcgggcg agctgtccga actgaccgac ctgctgcgcg gcaccgccgt
     9361 caccctgccc gccgggccgc cccaggcggg catggtgacc ctgggcgtgg cggccaggct
     9421 gagcgaacgg ctgagcctga cggagctcgt cgaacggatg aactcctggt acgcccaggc
     9481 cctggacgtg ctcgtcatcg ccgacgccgt ctggtcggcg ctgcccaccc ggatcgacct
     9541 gctcgccgcc gagctcgggc gcgtccgctc cctcgcccac tccgtgggcg tcctgccggg
     9601 cgagcacccg gcgggcgacg acctggagcg cctcaccatg gaactggccg cgctgcggtc
     9661 cgaggtgata tccgatccgc tcgtcttctg gaccggcgcc ccgcccagct ccgcgcccgg
     9721 cggccgcccc gacaccgccc gctacgaccg tgccgagcgc gccctggagg acgtgcgccg
     9781 ggaggtggag gccgtcctcg acgtccgcca ggacgccgag cgccggctga tgcgcgtgcg
     9841 cgacgtcctc tcgcgcgccg accgcaccct gggcgaggcc cgccgggccc ggatggaggt
     9901 cctgtcgaag atcgccgcct atgaggtgcc cgtggtctcc gggccgccga ccgtgctcta
     9961 cgagcagctg gagacggccg gcgagtaccg caggcgcgcc gcgtggcacc ggctctcccc
    10021 gctcctggag ggcctggagc ggcacgccga ggaggagttg ctgcgcgccc gcgagtcgct
    10081 gacggcggtc acggcgccgc tggccgtacg ggccgagctg cgcggccggc tcgacgcgta
    10141 caaggccaag gcggcgcggc tgggcctggc ggaggacggc ctcgtcatgg agcggtacga
    10201 cgtggcgcgc cgcatgctgt ggagcgcgcc ctgcgatctc gtcgccgccg agcaggcggt
    10261 gctgcgctat cagcgggccg tggccggggc gccggcccca cggggctcgg ccgcctcgga
    10321 accgacgggc acagggggga cgcatgaccg gtgaggagtg ccagcgcccg ggctgcgccg
    10381 gccgctacga agacgtgggc gacggcga
//
