LOCUS       NZ_CP034587            10378 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   NZ_CP034587
VERSION     NZ_CP034587.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2018) School of Life Sciences, Ludong University,
            186 Hongqi Road, Zhifu Distric, Yantai, Shandong 264025, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 247.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003970715.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:34:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,575
            CDSs (total)                      :: 6,474
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 104 of 198
            Pseudo Genes (incomplete)         :: 118 of 198
            Pseudo Genes (internal stop)      :: 12 of 198
            Pseudo Genes (multiple problems)  :: 30 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:02:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1249567
            Orig. end                         :: 1259945
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034587.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10378
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="15"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10378
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10378
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5378](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5378
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     misc_feature    149..164
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.23"
                     /tool="antismash"
     gene            249..1478
                     /locus_tag="EKH77_RS05025"
                     /old_locus_tag="EKH77_05025"
     CDS             249..1478
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174904.1"
                     /locus_tag="EKH77_RS05025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05025"
                     /product="glycoside hydrolase family 18 protein"
                     /protein_id="WP_240667696.1"
                     /transl_table=11
                     /translation="MPGPLRKRARTWLTAVAAGAALLAGGLTASPATADDTTDTSAGRR
                     VVGYFTDWGVYERNYHVKNIETSGSAAKLTHINYAFGNVTGGKCAIGDAYADYDRFYDA
                     VGSVDGKADTWDDGALRGNFNQLRKLKKLHPNLKVVWSFGGWTWSGGFGEAAKNPAAFA
                     ESCYGLVKDPRWADVFDGIDIDWEYPNACGLTCDTSGRTAFRDVMAALRARFGSKSLVT
                     AAITADASAGGKIDAVDYAGAARYVDWYNPMTYDYFGAWEAKGPTAPHSPLTSYNGIPK
                     AGFDTDATITKLQALGIPSSKLLLGIGFYGRGWTGVTQSAPGGTATGPAKGTYEAGFED
                     YRVLRNTCPATGTVGGTAYAKCGNDWWSYDTPSTIAGKMAYKNRQNLGGTFFWELSGDT
                     ADGELIKSIN"
     gene            complement(1559..2431)
                     /locus_tag="EKH77_RS05030"
                     /old_locus_tag="EKH77_05030"
     CDS             complement(1559..2431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016432720.1"
                     /locus_tag="EKH77_RS05030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05030"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_126913229.1"
                     /transl_table=11
                     /translation="MTASWLGPGKASAVALTFDVDAETGVLSMGEKYARHAMTMTHQAF
                     GPDVGVPRILGILRELGVPATFFFPGWVAERRPNLVARVVEAGHEVAHHSYSHVPATSM
                     TFAEERNDFERALEVFQKQDVPVYGHRAGLWEASWQTASLVAEYGLAYDSSMMNDDRPY
                     HVPTERGDVVELPPHWSLDDWEQYAFLPAPQIGSIIEDPQKVLSMWKYELDAMRRYNSL
                     FMLTNHPFLTGRPGRAEALRSLIEYGMSHGDVEFLTCREIAERAKADTSLATRPLEQPE
                     IEPGLFPSE"
     misc_feature    complement(2425..2445)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.85"
                     /tool="antismash"
     gene            2700..3251
                     /locus_tag="EKH77_RS05035"
                     /old_locus_tag="EKH77_05035"
     CDS             2700..3251
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013756.4"
                     /locus_tag="EKH77_RS05035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05035"
                     /product="flavin reductase family protein"
                     /protein_id="WP_164737742.1"
                     /transl_table=11
                     /translation="MALPPTSRVRAQPEECPEREFRAAAGKFASGVTVVATRNGGEVFA
                     KTVSAFGSLSLEPRMVSVSIGRMSPLVTAVLATEVFAVSVLRDDQQRVSRHFATRGNGR
                     AIGSFPSVATESFVTGAPVVSGSLSYFDCRLESVVGGGDHALLIGRVVATGSVPGRPLV
                     YFDGGYREIDASGATTGVSA"
     misc_feature    2706..2708
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3248..4738
                     /locus_tag="EKH77_RS05040"
                     /old_locus_tag="EKH77_05040"
     CDS             3248..4738
                     /NRPS_PKS="Domain: AMP-binding (7-398). E-value: 1.1e-67.
                     Score: 220.3. Matches aSDomain:
                     nrpspksdomains_EKH77_RS05040_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006344658.1"
                     /locus_tag="EKH77_RS05040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05040"
                     /product="AMP-binding protein"
                     /protein_id="WP_126913231.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-69, bitscore:
                     233.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPLTAAFDDHARHTPEAPALIWRGTSVPYGELGALAGVFQERLR
                     HLGGHRAAPVCVPARRTPETLALLVAALRDGRPVLLPSAELGADTLRELTAGAGIDRVL
                     TAEPAYDAPGGLGVETIVPRPDAPAVPEGTGLLLTTSGSTGTPKVVPLPLDAVGRFISW
                     AAEHFGLGPDTAVLNYAPLNFDLCLLEVWTTLAVGGRVVLVDPDRATDGAHLRELISAH
                     DIHLVQGVPLLYRLLTEGADPAEPLKSVRHVVLTGDAVPPRLLARLPGLFPDASFANVY
                     GCTETNDSLILDAGPLLPGDPETAGPLPLGRPLPGVRALVLGEDGQPLDGPGTGELLVH
                     TPFQAHGYLDPARGADRFVRRADADGPRVWFRSGDLVRRTADGTLHLVGRTDFQVKVRG
                     VRISLEEVEQTLLAHPEVADAVVVTVPDEAAGKRLQALVRRTPGSALHVLALREHCARR
                     LARTAIPSDIRVVDAALPKGPTGKNDRAAVGDVRRLKG"
     aSDomain        3269..4441
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKH77_RS05040_AMP-binding.1"
                     /evalue="1.10E-67"
                     /label="EKH77_RS05040_AMP-binding.1"
                     /locus_tag="EKH77_RS05040"
                     /protein_end="398"
                     /protein_start="7"
                     /score="220.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FDDHARHTPEAPALIWRGTSVPYGELGALAGVFQERLRHLGGHRA
                     APVCVPARRTPETLALLVAALRDGRPVLLPSAELGADTLRELTAGAGIDRVLTAEPAYD
                     APGGLGVETIVPRPDAPAVPEGTGLLLTTSGSTGTPKVVPLPLDAVGRFISWAAEHFGL
                     GPDTAVLNYAPLNFDLCLLEVWTTLAVGGRVVLVDPDRATDGAHLRELISAHDIHLVQG
                     VPLLYRLLTEGADPAEPLKSVRHVVLTGDAVPPRLLARLPGLFPDASFANVYGCTETND
                     SLILDAGPLLPGDPETAGPLPLGRPLPGVRALVLGEDGQPLDGPGTGELLVHTPFQAHG
                     YLDPARGADRFVRRADADGPRVWFRSGDLVRRTADGTLHLVGRTDFQVKVR"
     CDS_motif       3656..3700
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKH77_RS05040_0001"
                     /evalue="2.80E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="EKH77_RS05040"
                     /protein_end="151"
                     /protein_start="136"
                     /score="13.9"
                     /tool="antismash"
                     /translation="LLTTSGSTGTPKVVP"
     CDS_motif       4247..4321
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKH77_RS05040_0002"
                     /evalue="5.50E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="EKH77_RS05040"
                     /protein_end="358"
                     /protein_start="333"
                     /score="12.4"
                     /tool="antismash"
                     /translation="TGELLVHTPFQAHGYLDPARGADRF"
     CDS_motif       4409..4471
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EKH77_RS05040_0003"
                     /evalue="5.60E-09"
                     /label="NRPS-A_a8"
                     /locus_tag="EKH77_RS05040"
                     /protein_end="408"
                     /protein_start="387"
                     /score="28.2"
                     /tool="antismash"
                     /translation="VGRTDFQVKVRGVRISLEEVE"
     gene            4745..5014
                     /locus_tag="EKH77_RS05045"
                     /old_locus_tag="EKH77_05045"
     CDS             4745..5014
                     /NRPS_PKS="Domain: PP-binding (13-61). E-value: 7.1e-07.
                     Score: 21.4. Matches aSDomain:
                     nrpspksdomains_EKH77_RS05045_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147: putative acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105939.1"
                     /locus_tag="EKH77_RS05045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05045"
                     /product="phosphopantetheine-binding protein"
                     /protein_id="WP_126913232.1"
                     /sec_met_domain="PP-binding (E-value: 3.2e-05, bitscore:
                     22.9, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRPAEIKRFLISEFLPDLSADQLDPDYDLLATGVIDSLQVVRVV
                     NWVTTRYGIPLDQVEITPGDFRSVNAIDAFVTAFEETRNHHVHA"
     aSDomain        4784..4927
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKH77_RS05045_PP-binding.1"
                     /evalue="7.10E-07"
                     /label="EKH77_RS05045_PP-binding.1"
                     /locus_tag="EKH77_RS05045"
                     /protein_end="61"
                     /protein_start="13"
                     /score="21.4"
                     /tool="antismash"
                     /translation="EFLPDLSADQLDPDYDLLATGVIDSLQVVRVVNWVTTRYGIPLDQ
                     VEI"
     gene            5001..5378
                     /locus_tag="EKH77_RS05050"
                     /old_locus_tag="EKH77_05050"
     CDS             5001..5378
                     /GO_function="GO:0033990 - ectoine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005321771.1"
                     /locus_tag="EKH77_RS05050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05050"
                     /product="ectoine synthase"
                     /protein_id="WP_126913233.1"
                     /sec_met_domain="ectoine_synt (E-value: 5.3e-30, bitscore:
                     102.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTREKDKVQTVEWGNGRSSRLLTESDGMGFTVADTLVRAGTKSR
                     LQYRRHLEACYCISGRGEVISADGSKSLAIEPGVLYALDEHDAHFLIADPDTDLHLISV
                     FNPPLRGDEVHSLDESGFSHY"
     gene            5457..6593
                     /locus_tag="EKH77_RS05055"
                     /old_locus_tag="EKH77_05055"
     CDS             5457..6593
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018105935.1"
                     /locus_tag="EKH77_RS05055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05055"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_346429046.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.5e-17, bitscore:
                     62.9, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.5e-22, bitscore:
                     78.2, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 2.7e-34, bitscore:
                     117.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHWSEDQRELRAAIAALGERLGEGHLERDRTGEFSHDNWKLLRES
                     DLFRLPFEERWGGLGQSLITTLYVLEGLGQACRDAGLSFSATTHMVSTGVPIQRFGSPA
                     LKERFLPAVCAGEVIGAHAISEPEAGSDMLSLRTTGRVEDGHLVLNGGKAFVTNGPIAD
                     VFVVYVSTGERGSPFGITAVVVERDRPGLTVGGPMAKMGLRTSPLSELFFDDCRVPLEN
                     VIGRVGTGFVVFDHVMKWEVLCSFVVNVGEMRARLERVVDYARTREQFGRPIGSHQAVA
                     HRIARMRVATDTARTALYEAARKVEAGEDATVEVATAKLLASEGNLASAVAAVQTFGGY
                     GYMAEYGLEQDLRNAVAGTIYSGTTDIQYSRIATTMGL"
     gene            6599..7291
                     /locus_tag="EKH77_RS05060"
                     /old_locus_tag="EKH77_05060"
     CDS             6599..7291
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010060204.1"
                     /locus_tag="EKH77_RS05060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05060"
                     /product="transglutaminase-like domain-containing protein"
                     /protein_id="WP_126913235.1"
                     /transl_table=11
                     /translation="MSTPDFAELLRPTEFLDHDSPEVRDFVARSGALEETTAAGKAVRL
                     YYAVRDGVDYEVYGTSLERAALRASSVARAGKGFCLHKSVLYAAAVRSVGVPSRLVYAD
                     VRNHLASERLRRMVGGEVFHHGLVSVHLDGRWTRVTPVFNGLLCRLYGMTPLEFDGTAD
                     SVYHPYDAQGARQMEFLTDYGDHADVPYERLMARMRAKHPGMFAEGAAGAAISGSGSLA
                     DEAPVPAP"
     gene            7348..7668
                     /locus_tag="EKH77_RS05065"
                     /old_locus_tag="EKH77_05065"
     CDS             7348..7668
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020419418.1"
                     /locus_tag="EKH77_RS05065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05065"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_126913236.1"
                     /transl_table=11
                     /translation="MAWIYLLIAIAFEIVFALGANASKGFTRLWISLITLVGIVGGIYF
                     ISLALRTLDVSVGYTIWTSVGALGTVVLGAVIFKEKITPAKLLCFAAIIGGVVGLKSMG
                     AA"
     misc_feature    complement(7391..7406)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.07"
                     /tool="antismash"
     gene            7668..8093
                     /locus_tag="EKH77_RS05070"
                     /old_locus_tag="EKH77_05070"
     CDS             7668..8093
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004955023.1"
                     /locus_tag="EKH77_RS05070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05070"
                     /product="multidrug efflux SMR transporter"
                     /protein_id="WP_126913237.1"
                     /transl_table=11
                     /translation="MGERRTESAKAWTLLLIAAAFEIVFALSSAANEGFTRLVPSLITA
                     VAGGGGVYLLSLALKTLDVGIGYTVWTGIGSVGAVVFGALLFGESITVGKVVCLVAIIG
                     GVLGLHMTTESTPEADQAADDAAGRPESVEPERTAKQ"
     gene            8090..9328
                     /locus_tag="EKH77_RS05075"
                     /old_locus_tag="EKH77_05075"
     CDS             8090..9328
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003952561.1"
                     /locus_tag="EKH77_RS05075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_05075"
                     /product="styrene monooxygenase/indole monooxygenase family
                     protein"
                     /protein_id="WP_126913238.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-06, bitscore:
                     26.7, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHSTRSIAVVGAGQAGLQLALGLRRSGHHVTLVSNRTARQVLDG
                     RVMSTQIMFADALETERRLGLDHWQGEAPAIEGLTFTVAPDAVKAIDFEARLAAPGQSV
                     DQRVKIAAWLEEFTAAGGELRIAEAGVAELEELAASHDLVLVTAGKGEISRIFERDAER
                     SPFTAPQRVAAVSYVHGLRPRDSFVACSASLMPGVGEYFIVPALTKSGPCDCLFLNGVP
                     GGPLDAFADVRSPEEHLDVTKKLLAEFLPWEAERAADAVLTDPGGVLAGRLTPTVREPV
                     ATLPSGRKVLGVADVLVVNDPLTGQGSNSAAKCADVYLREILARGDEPFDADWMTATFE
                     RFWEYARHVTRWTNGLLPPAPAHVVDLLDAAQRQPGLASRIAEGFNNPTGLDPWWHEPE
                     AARREILPEPAVR"
ORIGIN
        1 gcgccgggtc gcgacatcgc gtgacctgcg gctgtggcgg ttggagtatg cccgttcgcg
       61 ggcgccgcgt caccggtcgg cagatcttga atccctacgg gccgcgggcg gaccatacgc
      121 aacggctttg gtacgaacca ttgaccgtat tggtctagtc ctcctacggt ttccccattg
      181 ttcaacgcgt ccatgccaag agcacgttcc tcccccaccg aggagacctc atgcccagac
      241 cgcacggaat gcccggaccg ctccgcaagc gcgcccgcac ctggctcacg gcggtggccg
      301 ccggggccgc cctgctcgcg ggcggcctca ccgcgagccc ggccacggcc gacgacacca
      361 cggacacctc ggccggccgg cgcgtggtcg gctacttcac cgactggggc gtctacgagc
      421 gcaattacca tgtgaagaac atcgagacct ccggctccgc cgcgaagctc acccacatca
      481 actacgcctt cggcaatgtc accggcggca agtgcgcgat cggcgacgcc tacgccgact
      541 acgacaggtt ctacgacgcc gtcggcagcg tcgacggcaa ggccgacacc tgggacgacg
      601 gcgccctgcg cggcaacttc aaccagctgc gcaagctcaa gaagctccac ccgaacctca
      661 aggtggtctg gtccttcggc ggctggacct ggtccggcgg cttcggcgag gcggcgaaga
      721 accccgccgc gttcgccgag tcctgttacg ggctggtcaa ggacccgcgc tgggccgatg
      781 tcttcgacgg catcgacatc gactgggagt accccaacgc ctgcgggctg acctgtgaca
      841 ccagcggccg caccgccttc cgcgacgtca tggcggcgct gcgcgccagg ttcgggagca
      901 agagcctggt gacggcggcc atcactgccg acgcctccgc cggcggcaag atcgacgccg
      961 tcgactacgc gggcgccgcc cgctacgtcg actggtacaa ccccatgacc tacgactact
     1021 tcggcgcctg ggaggccaag ggccccaccg ccccccactc gcccctgacg tcctacaacg
     1081 gcatcccgaa ggccgggttc gacacggacg ccaccatcac caagctccag gcgctcggca
     1141 tcccgtcgtc caagctgctg ctgggcatcg gcttctacgg gcgcggctgg accggcgtca
     1201 cccagtccgc ccccggcggc acggccaccg ggcccgcgaa gggcacctac gaggccggct
     1261 tcgaggacta ccgggtgctc aggaacacct gcccggccac gggcacggtc gggggcaccg
     1321 cctacgccaa gtgcggcaac gactggtgga gctacgacac accgtcgacc atcgccggga
     1381 agatggcgta caagaaccgg cagaacctgg gcggcacgtt cttctgggag ctcagcggcg
     1441 acacggccga cggcgagctg atcaagtcca tcaactgatc cccgactgat cccaccgaaa
     1501 aagcgcctcc cgtccggcag tcccggacgg gaggcgctcg tcgtctccca ctcggatctc
     1561 actccgacgg gaagagcccc ggctcgatct ccggctgctc cagcggccgg gtggccagcg
     1621 aggtgtcggc cttggcgcgc tcggctatct cacggcacgt caggaactcc acgtcgccgt
     1681 gcgacatccc gtactcgatc agggagcgca gcgcctccgc ccggcccgga cggccggtga
     1741 ggaaggggtg gttggtgagc atgaacagcg agttgtagcg ccgcatcgcg tccagctcgt
     1801 acttccacat cgacagcacc ttctgcgggt cctcgatgat ggagccgatc tgcggcgccg
     1861 gcaggaacgc gtactgctcc cagtcgtcca gcgaccagtg cgggggcagt tccacgacgt
     1921 cgccccgctc ggtgggtaca tggtaggggc ggtcgtcgtt catcatcgac gagtcgtagg
     1981 ccagcccgta ctccgcgacc agcgaggccg tctgccagct cgcctcccac agcccggccc
     2041 ggtggccgta cacgggcacg tcctgcttct ggaagacctc cagggcgcgc tcgaagtcgt
     2101 tccgttcctc ggcgaacgtc atcgacgtcg ccggtacatg gctgtaggag tggtgcgcca
     2161 cctcgtggcc cgcctccacc acccgcgcca ccagattcgg gcggcgctcg gccacccagc
     2221 ccgggaagaa gaacgtggcg ggcacgccga gttcgcgcag aattcccagg atgcgcggca
     2281 cgccgacatc ggggccgaat gcctgatggg tcatcgtcat cgcgtgccgt gcgtacttct
     2341 cgcccatgga gagcacaccg gtctcagcgt ccacatcgaa tgtgagcgcc accgccgagg
     2401 cctttccggg gccaagccag gatgcagtca tgaaagtgac cctaaacagg gcggaggccc
     2461 ttcacaatgg acactcgcac atgatcacga ccccttccgt gtagatctgt acaaccgccc
     2521 ccaccggtag cctggttagc ggccgcgacc tgcgccgata cggtcccgcc gggacccctc
     2581 accactcgga cgggtagccg ggcggcacta cccgaagagg tagtggaagc ggcttcaccg
     2641 cacctcgtac agtcatggac gtccccgaga aaagccctca cggaatggca gtgacagtga
     2701 tggcattacc cccgacgtcc cgggtgcggg cgcagcccga agaatgcccg gagcgggaat
     2761 tccgcgcggc ggccggtaaa ttcgcgtccg gtgtcacggt ggtcgcgaca agaaatggcg
     2821 gcgaagtgtt cgccaagacc gtctcggcat tcgggtcgct ctccctggag ccgcggatgg
     2881 tgtccgtgtc catcgggcgg atgagcccgc tggtgacggc ggtcctcgcc accgaggtct
     2941 tcgcggtcag cgtgctccgc gacgaccagc agcgcgtctc ccgccacttc gccacccgag
     3001 gcaacggcag ggccatcggc tccttcccgt ccgtggccac cgaatcattc gtcaccggcg
     3061 ccccggtcgt cagcggatcc ctcagctatt tcgactgccg gctggagagc gtggtgggcg
     3121 gcggcgacca cgccctcctg atcggccggg tggtcgccac cggcagcgtc ccgggccgcc
     3181 cgctggtcta cttcgacggc ggctaccggg agatcgacgc gtccggcgcc acgacgggcg
     3241 tctccgcatg agcccgctca ccgccgcctt cgacgaccat gcccggcaca ccccggaggc
     3301 ccccgccctg atctggcgcg gcacgtccgt cccgtacggc gaactgggcg cgctcgcggg
     3361 cgtcttccag gagcggctgc gccacctggg cggccaccgc gcggcccccg tgtgcgtacc
     3421 cgcccgccga acgcccgaga ccctggccct gctcgtcgcc gctctgcgcg acggccgtcc
     3481 cgtgctgctg ccctccgccg agctcggcgc cgacaccctg cgcgagctga ccgccggcgc
     3541 gggcatcgac cgggtgctga ccgccgaacc cgcctacgac gcgcccggcg gcctcggcgt
     3601 cgagacgatc gttccccggc cggacgcccc ggccgtcccc gaggggacgg gcctgctgct
     3661 caccacgtcc ggctccaccg ggacgcccaa ggtggtgccc ctgccgctgg acgccgtcgg
     3721 ccgcttcatc tcctgggcgg cggagcactt cggcctcggg ccggacacgg cggtgctcaa
     3781 ctacgcgccc ctcaacttcg acctgtgcct gctggaggtg tggacgaccc tggccgtcgg
     3841 cggccgcgtg gtgctcgtcg acccggaccg ggccaccgac ggggcgcatc tgcgcgagct
     3901 gatctccgcc catgacatcc acctcgtgca gggcgtgccg ctgctctacc ggctgctcac
     3961 cgagggcgcg gaccccgcgg agccgctgaa gtcggtgcgg catgtcgtcc tcaccggtga
     4021 cgcggtgccg ccgcggctgc tcgcccggct gccggggctc ttcccggacg cctccttcgc
     4081 caatgtctac ggctgcaccg agaccaacga cagcctgatc ctcgacgccg ggccgctgct
     4141 gcccggcgac ccggagacgg cgggcccgct gccgctcggc agaccgctgc cgggcgtccg
     4201 cgccctcgtc ctcggggagg acgggcagcc gctcgacggg cccggcaccg gcgaactgct
     4261 ggtgcacacc cccttccagg cgcacggcta cctggatccc gcgcgcggcg ccgaccggtt
     4321 cgtccgccgc gccgacgcgg acgggccccg ggtctggttc cgcagcgggg acctcgtccg
     4381 gcggaccgcc gacggcaccc tccacctggt cgggcgcacc gacttccagg tcaaggtgcg
     4441 cggcgtgcgg atctcgctgg aggaggtcga gcagaccctg ctggcccacc ccgaggtggc
     4501 cgatgccgtg gtcgtcaccg tccccgacga ggcggccggc aaacggctcc aggccctcgt
     4561 gcgccgcacc cccggctccg ccctccatgt cctcgccctg cgcgagcact gcgcccggcg
     4621 gctggccaga accgcgatac ccagcgacat ccgcgtcgtc gacgcggccc tgccgaaggg
     4681 ccccaccgga aagaacgacc gcgccgccgt cggcgacgta cggcggctga agggataaca
     4741 gggcatgaac cgccccgcgg aaatcaagcg cttcctgatc tcggagttcc tgccggacct
     4801 gagcgccgat cagctcgatc ccgactacga cctgctggcg acgggcgtga tcgacagcct
     4861 tcaggtggtc cgggtcgtca actgggtcac cacccgttac ggcatcccgc tcgaccaggt
     4921 cgagatcacc cccggcgact tccgttccgt gaacgccatc gacgcgttcg tcaccgcttt
     4981 cgaagagacg aggaaccacc atgttcacgc gtgagaagga caaggtccag acggtcgagt
     5041 ggggcaacgg gcgcagcagc aggctgctga ccgagtccga cggcatgggg ttcaccgtgg
     5101 ccgacacgct cgtccgcgcc ggcaccaagt cccggctgca gtaccgccgg cacctggagg
     5161 cctgctactg catcagcggc cggggcgagg tcatcagcgc cgacggctcg aagagcctcg
     5221 ccatcgagcc cggtgtgctc tacgccctcg acgagcacga cgcccacttc ctcatcgccg
     5281 accccgacac cgatctccac ctgatcagcg tcttcaaccc gccgttgcgg ggcgacgagg
     5341 tgcacagcct cgacgagagc ggcttctccc actactagag cgcccgtgga cgggaggccg
     5401 ggcacttctc ccctccggcc tccccgtccg gaccacaccg agaaggtcga tagctgatgc
     5461 actggtcgga agatcagcga gaactgcggg ccgcgatcgc ggccctgggc gaacggctcg
     5521 gcgaggggca cctggagcgc gaccgcacgg gcgagttctc gcacgacaac tggaagctgc
     5581 tgcgcgagtc ggacctgttc cggctgccct tcgaggagcg ctggggcggc ctcggccagt
     5641 ccctcatcac caccctgtac gtcctggagg gcctcggcca ggcgtgccgc gacgcgggcc
     5701 tgagcttctc ggcgaccacg cacatggtga gcaccggtgt gccgatccag cgcttcggct
     5761 cgcccgcgct caaggagcgg ttcctgccgg cggtgtgcgc gggcgaggtg atcggcgccc
     5821 acgcgatctc cgagccggag gccggctcgg acatgctctc cctgcgcacc acgggccggg
     5881 tcgaggacgg tcacctcgtc ctcaacggcg gcaaggcgtt cgtcaccaac ggccccatag
     5941 ccgacgtgtt cgtcgtgtac gtctcgacgg gcgagcgcgg cagcccgttc gggatcacgg
     6001 ccgtcgtcgt cgagcgcgac cggcccggcc tgacggtggg cggtccgatg gcgaagatgg
     6061 gcctgcgcac ctccccgctc tccgagctgt tcttcgacga ctgccgggtg cccctggaga
     6121 acgtcatcgg ccgcgtcggc acgggcttcg tcgtcttcga ccacgtgatg aagtgggagg
     6181 tcctgtgctc cttcgtcgtg aacgtcggcg agatgcgggc ccgcctggag cgcgtggtcg
     6241 actacgcccg cacccgtgag cagttcggca ggccgatcgg ctcccaccag gccgtggccc
     6301 accggatcgc gcggatgcgc gtcgccaccg acaccgcccg gaccgccctg tacgaggcgg
     6361 cgcggaaggt cgaggcgggc gaggacgcca cggtggaggt cgccaccgcc aagctcctgg
     6421 ccagcgaggg caacctcgcc tccgccgtcg cggccgtgca gaccttcggc ggctacggct
     6481 acatggccga gtacggcctg gagcaggacc tgcgcaacgc cgtcgccgga acgatctact
     6541 cgggcaccac cgacatccag tactcccgca tcgccaccac gatgggtctt tgaggacgat
     6601 gagcacacca gacttcgcgg aacttctgcg tcccaccgaa ttcctcgacc acgactcccc
     6661 ggaggtccgc gacttcgtcg cgcggtccgg ggccctggag gagaccaccg cggccgggaa
     6721 ggccgtccgg ctctactacg ccgtgcgcga cggcgtcgac tacgaggtct acggcaccag
     6781 cctggagcgc gccgcgctgc gggcgagctc ggtggcccgc gccggaaagg gcttctgcct
     6841 ccacaagtcc gtgctctacg cggcggcggt ccgctcggtc ggcgtcccca gccggctggt
     6901 ctacgccgat gtgcgcaacc acctcgcctc ggagcggctg cggcgcatgg tgggcggcga
     6961 ggtcttccac cacggcctgg tctccgtcca cctcgacggc cgctggacgc gcgtcacccc
     7021 ggtcttcaac ggcctgctgt gccgcctgta cgggatgacg ccgctggagt tcgacggcac
     7081 cgccgacagc gtgtaccacc cctacgacgc ccagggcgcg cggcagatgg agttcctcac
     7141 ggactacggc gaccacgccg acgtgccgta cgagcggctg atggcgcgca tgcgcgccaa
     7201 gcaccccggc atgttcgccg agggggccgc cggggccgcg atctccggca gcggctcgct
     7261 cgccgacgaa gcgcccgtcc ccgcaccgta gaccgccccg aaaaccaccc ggcaacaccc
     7321 ggaaaaccac ccggaagtca ccactccatg gcctggatct accttctcat cgccatcgcg
     7381 ttcgagatcg tcttcgctct cggcgcgaac gcctccaagg gcttcacccg cctgtggatc
     7441 tcgctgatca ccctggtcgg catcgtcggc ggcatctact tcatcagcct cgccctgcgc
     7501 acgctggacg tgagcgtcgg ctacacgatc tggacgagcg tgggcgccct gggcacggtc
     7561 gtcctcggtg ccgtgatctt caaggagaag atcacgcccg ccaagctgct gtgcttcgcc
     7621 gccatcatcg gcggcgtggt cggcctcaag tcgatggggg cggcctgatg ggcgagcgac
     7681 gcaccgagag cgcgaaggcg tggacgctgc tgctgatcgc ggccgccttc gagatcgtct
     7741 tcgccctgag ctccgccgcc aacgagggct tcacgcgcct cgtgccgtcc ctgatcaccg
     7801 cggtggcggg cggcggcggc gtgtacctgc tgagcctcgc gctcaaaacg ctcgacgtcg
     7861 gcatcggcta caccgtctgg accggcatcg gctcggtggg cgcggtggtc ttcggggccc
     7921 tgctgttcgg cgagagcatc acggtcggca aggtcgtgtg cctcgtggcg atcatcggcg
     7981 gcgtgctggg cctccatatg acgacggaga gcacccccga ggcggaccag gcggcggacg
     8041 acgcggccgg ccgtccggaa tccgtggaac cggaaaggac agcgaagcaa tgaagcacag
     8101 cacgcggtcg atcgccgtcg tcggggcggg ccaggcgggc ctgcagctcg ccctcggcct
     8161 gcgccgctcc ggccatcacg tcaccctcgt gtcgaacagg accgcgcggc aggtcctcga
     8221 cggccgggtg atgtccaccc agatcatgtt cgccgacgcc ctggagaccg agcgccgcct
     8281 gggcctggac cactggcaag gcgaggcacc cgccatcgag ggcctgacct tcaccgtggc
     8341 ccccgacgcc gtcaaggcca tcgacttcga ggcccggctg gcggccccgg gccagtcggt
     8401 cgaccagcgc gtcaagatcg ccgcctggct ggaggagttc acggccgccg gaggcgagct
     8461 gcgtatcgcc gaggcgggcg tggcggagct ggaggagctg gccgcgagcc acgacctcgt
     8521 gctcgtcacc gccggcaagg gcgagatctc ccggatcttc gaacgcgacg cggaacgctc
     8581 accgttcacc gccccgcagc gcgtcgcggc cgtctcctat gtccacggcc tgcgcccccg
     8641 cgactccttc gtcgcctgct cggccagcct catgccgggc gtcggcgagt acttcatcgt
     8701 cccggcgctg acgaagagcg gcccctgcga ctgcctgttc ctcaacggcg tgcccggcgg
     8761 ccccctggac gccttcgcgg acgtccgctc ccccgaggag cacctggacg tcaccaagaa
     8821 gctgctcgcc gagttcctgc cgtgggaggc cgagcgggcc gccgacgcgg tgctcaccga
     8881 cccgggcggg gtgctcgccg gacggctgac gccgaccgtg cgcgagccgg tcgccaccct
     8941 gccctcgggc cggaaggtcc tgggcgtcgc cgacgtcctc gtcgtcaacg acccgctgac
     9001 cggccagggc tccaacagcg ccgccaagtg cgccgacgtc tacctgcggg agatcctcgc
     9061 gcgcggggac gagcccttcg acgccgactg gatgacggcc acgttcgagc ggttctggga
     9121 gtacgcccgg cacgtcaccc gctggaccaa cggtctgctg cccccggcgc ccgcccatgt
     9181 ggtggacctg ctcgacgccg cccagcggca gcccgggctg gcgagccgga tcgcggaggg
     9241 cttcaacaac ccgacgggcc tggacccctg gtggcacgaa cccgaggcgg cccgccggga
     9301 gatcctcccc gaaccggccg tccgctgagg gggcggggag aggcatcatg acggacctgc
     9361 ccggtctgtc cttccgggcc gccctcgcgg cggcccggaa ggaggacccg cacacccacc
     9421 acacctacga ccagccgctc acccgccacg agatcgccgc acactacgcc gcgcggcacg
     9481 cgggcatccc cgccacgtcc tcctcgcgcg ccgaggacat cgccctgtac acccgcgtca
     9541 ccgacgcgtc cgccggaatg ccggtggtgc tcggggcgtt cggcgacgcg gagcgcctgc
     9601 ggcgctggct gcccggcctg ccccggcggg tgaacgggga caccgtctcc cggctgctcg
     9661 ccgcctgcca ggagcccaag cacctggaga gctcgccgtt cccccaggta cagcgcggcg
     9721 cggacgtcga cctcggggcg ctgcccgcgc tgtgggccac cgagcgcgac gccggcccct
     9781 acctgaccac cgggctgctg tacgcccacg acccccgcac cgggcgtgcc gccaccgccg
     9841 tgcaccggat gctcgtccgg gaccggaacc agctggtgat ctggatgctg cccagccgcc
     9901 ggctgctggc gatgtaccac gaggcggtgg agcggggcga tcgcctgccg gtgtcggtga
     9961 acctcggcgc gccgcccgcc gcgatggtgg cgtcggcggt gggcagcgac ttcctgcccg
    10021 ccggcacgag caaggcggcc ctggcgggcg cgctggccgg cgggccggtg acgctggccc
    10081 cggcggtgag ccggccggtg ccggtgttcg ccgagtcgga gatcgtcctg gaggggtact
    10141 tcgacgggac gaccgcgccg gaggcgctgc cgggccggga ggtgggtcac tcgctgccgg
    10201 aggtgctggg ctacgacggc aacgcggccg agagccttcc ggcgatcacg gtcacggcgg
    10261 tgacgtcgcg cgatgcgccg gtgttcccgg cggtgatcgg gccgggccgg gagcagtcgc
    10321 tgatcctggg gctggcgggc gcggtggcgc tggggctgtc gggggcgggc ggcgagct
//
