LOCUS       NZ_CP034587            10939 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   NZ_CP034587
VERSION     NZ_CP034587.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2018) School of Life Sciences, Ludong University,
            186 Hongqi Road, Zhifu Distric, Yantai, Shandong 264025, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 247.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003970715.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:34:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,575
            CDSs (total)                      :: 6,474
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 104 of 198
            Pseudo Genes (incomplete)         :: 118 of 198
            Pseudo Genes (internal stop)      :: 12 of 198
            Pseudo Genes (multiple problems)  :: 30 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:02:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 188011
            Orig. end                         :: 198950
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034587.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10939
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="4"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10939
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10939
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5939](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5939
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    529..542
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.02"
                     /tool="antismash"
     misc_feature    complement(529..543)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.91"
                     /tool="antismash"
     gene            complement(534..1199)
                     /locus_tag="EKH77_RS00860"
                     /old_locus_tag="EKH77_00860"
     CDS             complement(534..1199)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008735287.1"
                     /locus_tag="EKH77_RS00860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00860"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_126912523.1"
                     /transl_table=11
                     /translation="MKISELSRRAGVPVASIKYFRREGLLPAGRATAATLAEYGEEHVQ
                     RLRLIKALTTLGGLSIAATRDVLAAVGEAHTTEGKLGAISYALPVPVADSPVADSAQGA
                     ADQTAAEAEVAELIAAMHWQTPDASPHVRGLTEALKALRRVDADYRPGELAAYAELANS
                     IARLDLERAATFGDDAEAVAERAVIVFALSAPVLELLRRLAQEDQVRRRVAERGEAFS"
     gene            1334..2641
                     /locus_tag="EKH77_RS00865"
                     /old_locus_tag="EKH77_00865"
     CDS             1334..2641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019070453.1"
                     /locus_tag="EKH77_RS00865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00865"
                     /product="YhgE/Pip family protein"
                     /protein_id="WP_240667156.1"
                     /transl_table=11
                     /translation="MSSLPSSSVLRSPRLWIGSGLILAVVSTLFALLYVGGNVNPKGNL
                     RDLPVALVNSDKGLDANGKHMNLGEQVVSGIKKSAEGNKSFDWQVLSRQEADKKLGQGK
                     LYGAVVVPQNFTAAVTGLTSPQQTQPARPTMTVLTNQSAGSFGSSMASQATQKAAHAAS
                     AQLGKQLLDRAAAQKAPLAPAAKLLLADPVSVQVADGHPLGTHSAMGLSAFYYALVLVV
                     CGMLGANALTNQVDTALGYLHSDFGPFRLRQPLQHTSRVRTLAISSVLMLAFSLVMGSI
                     VEAATVGILGMDASHLGLLWVYSVATIAVVGISALTLLSVFGVPGMLLSAIVFVAMAVP
                     SSGATVPLEALPGFFRWLSEFEPLRQITGGMRSILYYDAQADAGLTRAWVSMGIALVVA
                     LLFGFGVTRLYDRKGLHRVPRPTEPADEAVPATAAA"
     misc_feature    2689..2704
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 21.81"
                     /tool="antismash"
     misc_feature    2696..2709
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.88"
                     /tool="antismash"
     gene            2913..4211
                     /locus_tag="EKH77_RS00870"
                     /old_locus_tag="EKH77_00870"
     CDS             2913..4211
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014696.4"
                     /locus_tag="EKH77_RS00870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00870"
                     /product="phosphatidylserine decarboxylase family protein"
                     /protein_id="WP_126912524.1"
                     /transl_table=11
                     /translation="MPRTTGTTFSAQQLETRYRNSFGRAAGYLPKNRAALDAWLEDFSR
                     GVHERRARNAIVRRRSVDDLARLIERDGIVRMYVSLMIDKANELHPDAKHRVNDIPDLL
                     DHLDCIVTSTPEYHPQGDPDRNFFPLSSLFVYMMMTEPGYAVFRDQGFNRALLGILREW
                     CAHLDSDDSQEVVNRTDGWLSPAAWDELGLDQFRIDPDDPHGGFPSYNAFFHRELKDDA
                     RPIDGDPNVVVSANDGRVVRIRRNIEHRDEQFWAKGQLYSLADMLDGSDLTDSFIGGDV
                     FQSFLSGGDYHRWHAPVTGVVRSARVVEALMFTELEGVEEPNAGTQSQVYGASVNTRGL
                     VFIEAPAPIGMVCVMPLGMTEISSVTLTVRPGDQVTKGDQLGYFSYGGSSMCLLFQKGA
                     IGEFLVPDNTTGDMEKGDPIKVNAGIARTTGRA"
     gene            4237..5046
                     /locus_tag="EKH77_RS00875"
                     /old_locus_tag="EKH77_00875"
     CDS             4237..5046
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKH77_RS00875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKH77_00875"
                     /product="hypothetical protein"
                     /protein_id="WP_126912525.1"
                     /transl_table=11
                     /translation="MEANGCGRPATGEELHVCMGLNSCAGQDADRTATMAGTGRCATVQ
                     HVCHGEGACRGQGGCGYAGDDFEQFHPGEQACCYNGSCASPINESRVFSGGPMKGRSVW
                     QQARRLFEARMYAAGKAFGPSPGQGVPDEHIPAYDHLTTPTVGASDKVTALFRASADNP
                     RRHEGVRFPDLQAIARNSVGRHLPGTEITFTVPDGDSALLYFKPDSGPQSAACTVTADD
                     QGVATAVPLYAGHTATEDQWVTVTATSSDGAARCEFHVRVLSPEGQR"
     gene            5001..5939
                     /locus_tag="EKH77_RS00880"
                     /old_locus_tag="EKH77_00880"
     CDS             5001..5939
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003818.1"
                     /locus_tag="EKH77_RS00880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00880"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_206279785.1"
                     /sec_met_domain="DUF692 (E-value: 7.7e-96, bitscore: 319.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVPCEGPVARGAAIKPGKAAGTATRTDTAARPPTPHLGFGLGLR
                     GPHIPYIRAHRPPVDFFEIISENHLRPGTDRRRVLDEIAEHYPIVLHGVSLSIGSTDPL
                     DLDYLRRLKRLADAVDTPWVSDHVCWTGVLGVHTHDLLPLPFTEESLRHVVRRARTVQE
                     ALERPLALENPSSYVEFRASTLTEWEFLSRLAEEADCGLLLDVNNVHVSAVNHGYDPEV
                     YLKALPHDRVWQMHLAGHTDYGTHLVDTHDAEVPDPVWDLYRLAVELTGGAATVIERDD
                     SLPPFPVLQAELDKARAVAAERAGPEGDRRD"
     gene            5932..6561
                     /locus_tag="EKH77_RS00885"
                     /old_locus_tag="EKH77_00885"
     CDS             5932..6561
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021364.4"
                     /locus_tag="EKH77_RS00885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00885"
                     /product="DNA-binding domain-containing protein"
                     /protein_id="WP_126912527.1"
                     /transl_table=11
                     /translation="MTDVPRSLDAIQQWMQTALLAPGGAAHVAEVITASGRMSAEERLR
                     VYRRGYRLRLLGCMRGQYPAMAHFLGRELFDGFAMEYLDAHPSRSPTLDDLGAGFPDHL
                     ARTRPDAGADDTPPEAWIDLLIDLARFERDFAAAFDAPDADTSTGADTGTRFFEARFPV
                     HRYAAAVRRGEEPEPPEAEPVRLSLTRRDGTVVVHDLTAPRPPQAG"
     gene            6592..7812
                     /locus_tag="EKH77_RS00890"
                     /old_locus_tag="EKH77_00890"
     CDS             6592..7812
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024306.4"
                     /locus_tag="EKH77_RS00890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00890"
                     /product="ferritin-like protein"
                     /protein_id="WP_126912528.1"
                     /transl_table=11
                     /translation="MPHLTARSAVRATDGITTLDELARHLTDAARIELSTIPPYLYAAY
                     SLKTSGYSQWAQGASAQRTLIGIAIEEMLHMALVRNVMVATKCETVDGKEFRFYDTDTI
                     PAYPGDMLHRLPPLTLHTQRISTAAIEGFMEVELPESKQQQTRKPSDEYHTLGELYDAI
                     GKGIVALSGRIAWGLDNTRWRQQYRRGYWNQWGGPPKPLPVVDQGSALDALYVIVEQGE
                     GAPDEQEDSHYQKFTRVRDHVDGIGVVDESGQQKYTIDSGDEAVWPVVTDPKATDFTGP
                     VRTLAELSDAAYCYVLALLDKLYRTPADDPMGNDAGPESVRYGLERGFVAAMQGVLSPV
                     AGLLVATPVGGGKNAGPTFGYYDLGARPKQALQDLCVRPELMAAYPQLGGGDGVLHQIS
                     LLPDFTL"
     gene            complement(7825..8310)
                     /locus_tag="EKH77_RS00895"
                     /old_locus_tag="EKH77_00895"
     CDS             complement(7825..8310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003985965.1"
                     /locus_tag="EKH77_RS00895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00895"
                     /product="DUF5709 domain-containing protein"
                     /protein_id="WP_126912529.1"
                     /transl_table=11
                     /translation="MSDDVMGDEVYQPARSDRRDNPGDLDLENALDGDLLDEVLDEGYS
                     PPEKPLGVGHHGTTAREQRERESLDQRLAEEVPDLPVPDGDGIGDQPGGDGEPIDEEVG
                     DVRAGRLTATIDAMPPRRNDVFARDVGIDGGAASAEEAAMHVVPDEPVAEFGEDIGT"
     gene            complement(8423..9376)
                     /locus_tag="EKH77_RS00900"
                     /old_locus_tag="EKH77_00900"
     CDS             complement(8423..9376)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020119296.1"
                     /locus_tag="EKH77_RS00900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00900"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_126912530.1"
                     /transl_table=11
                     /translation="MTTVALAVTDGVSHFELAAPCEVFGVDRSDLADPWYELTVCGPAG
                     ARVGGRFRLEPDEGLDGLVRAHTVIVPAWADLDEEPPAELVDAVRAAHRAGARIVSLCT
                     GAFVLAAAGLLDGRRATTHWLHAPALAAKYPGVRVDADVLYVDDGSVLTSAGKAAAMDL
                     CLHLVRLDHGSAVANAVARRLVVPPQREGGQAQFVATPAPDPRSHALSGLFTWALRRLD
                     RPLTVEDLARQANMSSRNLARHFNAVTGTTPLRWLRAHRIRRAQELLETTDDSVEAIAE
                     ATGMGTAASLRRHFNRTVGVPPDTYRRTFRGRTAGG"
     gene            9500..10543
                     /locus_tag="EKH77_RS00905"
                     /old_locus_tag="EKH77_00905"
     CDS             9500..10543
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010471644.1"
                     /locus_tag="EKH77_RS00905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00905"
                     /product="saccharopine dehydrogenase NADP-binding
                     domain-containing protein"
                     /protein_id="WP_126912531.1"
                     /transl_table=11
                     /translation="MGTSGQVAVLGAYGHTGRFVVAELLERGLRPVLCGRDTGRLDALA
                     GRHSGVRPGLGVRPATVGDPASLDRALAGADAVINCAGPFAGTASPVIEAALRARIPYV
                     DVAGEVEAVADTFTQFAERAEAAGVTVVPAMAFFGGLGDLLVTAALGDRRSADEVFLAY
                     ALSSWHPTAGTRASSAVSRERREGRRLVHADGRLELRTDKAPTGRWSFPAPVGNQAVVR
                     EFTTADSVTISRHVSVPVVDTCMTSGAVQDVLAPGAPAPAPVDDLGRSAQTFLVEAVVR
                     SGGTERRAVARGRDIYAVSAPLAVEAVLRVLGGRARRAGVASAGELFDARDFLASLAPH
                     VSVEFAH"
     misc_feature    10688..10702
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.93"
                     /tool="antismash"
ORIGIN
        1 tgtccttgat ctggtcgtag accttgttcc agcccaccgg cttgtaccgc atcagcgccc
       61 cctccttctt ccagcggggg aagtcgtcga gggtctggag gtggacgacg tcggcgacga
      121 ccttgtgctc ggctatctgg ttgtcgaggc gggcgtcgtg gttcttgctg aagtcgacga
      181 cggtgtcgac cttcatcttg gggaactgct tgaggaaggc gttcttgagg tagtcggcct
      241 ggcccggctt gtcgccgccg gcgtagacga ccaggcgacc gccctcggcc agagcgtcct
      301 tgtacagctt ctgcagctgc tcgtcctcgc tcgcgctctt cgccgcgggg tgggcggagg
      361 gggtggcggc ggcgacggtg gctccgctcg cggcgagcac gccgagggcg actgccgtgg
      421 cccatgcctt ccgggtggac ttcacaacga ctccttcgtg aggggggaag ccagagttct
      481 tgaagtttca agaaccggct cgcggctcac tctaggccga tgttcttgaa ctttcaagaa
      541 aaggcttcgc cacgctccgc gacgcggcgg cggacctggt cctcctgcgc gaggcggcgc
      601 agcagctcca gcacgggggc ggagagggcg aagacgatga ccgcccgttc ggccacggcc
      661 tccgcgtcgt caccgaaggt ggccgcgcgt tcgaggtcca gccgggcgat ggagttggcc
      721 agctccgcgt aggcggcgag ctcacccggc cggtagtccg cgtcgacccg cctgagcgcc
      781 ttcagcgcct cggtcagccc ccgtacgtgc ggggaggcgt cgggcgtctg ccagtgcatg
      841 gccgcgatca gctcggccac ctccgcttcg gcggccgtct ggtccgccgc gccctgagcg
      901 gagtccgcga cgggcgagtc cgccacgggc accggcaggg cgtagctgat ggcgccgagc
      961 ttcccctcgg tggtgtgggc ctcgccgacg gccgccagca cgtcccgggt ggcggcgatg
     1021 gacagccctc ccagcgtggt cagcgccttg atcagccgca gccgctggac gtgctcctcg
     1081 ccgtactcgg ccagcgtcgc ggccgtcgcc cggccggcgg gcagcaggcc ttcgcgccgg
     1141 aagtacttga tgctggcgac gggcacgccg gccctgcggc tgagctcgga gatcttcatg
     1201 cggcttcctc gctggtgatg cgaaccgggt atccgggttc aacgattgga cacccctgtt
     1261 ggatactgcc actatctagc acctggatac cttcgatatc tagctactct gcgtcatcac
     1321 cccggagcga tcattgtctt ccctcccgtc ctcgtccgtg ctccgcagcc cacggctgtg
     1381 gatcggctcg ggcctcatcc tcgcggtggt ctccaccttg ttcgccctgc tgtacgtggg
     1441 cggcaacgtc aaccccaagg gcaacctgcg cgacctgccc gtcgccctgg tcaacagtga
     1501 caaggggctc gacgccaacg gcaagcacat gaacctcggc gagcaggtcg tctccggcat
     1561 caagaagtcc gccgagggca acaagagctt cgactggcag gtcctcagcc gtcaggaggc
     1621 cgacaagaag ctcggccagg gcaagctcta cggcgcggtc gtcgttccgc agaacttcac
     1681 cgccgcggtg acagggctga ccagccccca gcagacccag ccggcccgtc cgacgatgac
     1741 ggtgctcacc aaccagtcgg cgggcagctt cggctcctcg atggcgagcc aggccacgca
     1801 gaaggccgca cacgccgcct ccgcgcagct cggcaagcag ctcctcgacc gcgccgccgc
     1861 ccagaaggcc ccgctcgccc cggccgccaa gctgctgctc gccgacccgg tgtccgtcca
     1921 ggtcgccgac ggccacccgc tcggcaccca cagcgccatg ggcctgagcg ccttctacta
     1981 cgcgctggtg ctggtcgtct gcggcatgct cggcgccaac gcgctcacca accaggtgga
     2041 caccgcgctc ggctacctcc actccgactt cggccccttc cgcctgcggc agcccctcca
     2101 gcacaccagc cgcgtgcgca cgctggccat cagctccgtc ctcatgctgg ccttctccct
     2161 ggtgatgggc tccatcgtcg aggccgccac cgtcggcatc ctcggcatgg acgcctccca
     2221 cctcggtctg ctgtgggtct actccgtggc cacgatcgcc gtcgtcggca tcagcgccct
     2281 gacgctcctc tccgtgttcg gcgtccccgg catgctgctc tcggccatcg tcttcgtcgc
     2341 catggccgtc ccgtcctccg gtgccaccgt gccactggag gcgctgcccg gcttcttccg
     2401 ctggctctcc gagttcgagc cgctccgcca gatcaccggc ggcatgcgct ccatcctcta
     2461 ctacgacgcc caggccgacg ccggcctgac ccgcgcctgg gtctccatgg gcatcgccct
     2521 ggtcgtcgcc ctgctcttcg gcttcggcgt cacgcgcctc tacgaccgca agggcctcca
     2581 ccgggtcccc cgccccaccg agccggccga cgaggccgtg ccggcgaccg cggcggcctg
     2641 atgtagccga cagcacatga agtgagggcg gggtccatcc ggaccccgcc ctcacttttt
     2701 tcacgccaac gggaggtttt tccaaggcgg ttgagaacgg gccaaactgt gtcgaaggcg
     2761 gcggacccct tagctgcgcg tgtcctccgg cgcgccggtc cggtaccgcc acggcggtgt
     2821 cctgttcccg gcaccatccc catggcgcgg ggttgagccg tctcggcggg atccgggaac
     2881 ctggtcggcc gcagccgaag gaggaggcat ccatgccccg taccaccggc acgaccttca
     2941 gcgcacagca gctcgagacc cgctaccgga attcgttcgg ccgggccgcc ggctatctgc
     3001 cgaagaaccg ggcggcgctc gacgcgtggc tggaggactt cagccgcggc gtccacgaga
     3061 ggcgcgcccg gaacgcgatc gtacggcgcc gttccgtcga cgacctggcc cggctgatcg
     3121 agcgggacgg gatcgtccgc atgtatgtga gcctgatgat cgacaaggcg aacgagctcc
     3181 accccgacgc caagcaccgg gtgaacgaca tccccgacct gctcgatcac ctggactgta
     3241 tcgtcacgtc cactcccgag taccaccccc agggcgaccc ggaccgcaac ttcttccccc
     3301 tgtcgtccct gttcgtctac atgatgatga cggagcccgg gtacgcggtc ttccgcgacc
     3361 aggggttcaa cagggcgctg ctcggcatcc tgcgcgagtg gtgcgcgcac ctcgacagcg
     3421 acgacagcca ggaagtggtg aaccgcacgg acggctggct gtcgccggcc gcctgggacg
     3481 agctcggcct cgaccagttc cggatcgacc cggacgaccc ccacggcggg ttcccctcct
     3541 acaacgcgtt cttccaccgc gagctcaagg acgacgcccg tcccatcgac ggcgacccga
     3601 acgtggtggt ctcggcgaac gacggcaggg tggtgcggat ccggcggaac atcgagcacc
     3661 gcgacgaaca gttctgggcc aaggggcagc tctactccct cgccgacatg ctcgacggca
     3721 gcgatctgac cgactcgttc atcggcggcg acgtcttcca gtcgttcctc tcgggcggcg
     3781 actaccaccg gtggcacgca cccgtcaccg gcgtcgtccg cagcgcccgg gtggtggagg
     3841 ccctgatgtt cacggagctg gaaggggtgg aggagcccaa cgccggtacg cagtcgcagg
     3901 tctacggcgc ctcggtcaac acccgggggc tggtgttcat cgaggccccc gcgccgatcg
     3961 gcatggtgtg cgtcatgccg ctgggcatga ccgagatctc atcggtcacg ctcaccgtgc
     4021 gccccggtga tcaggtgacc aagggcgacc agctcggcta cttcagctac ggcggctcca
     4081 gcatgtgcct gctgttccag aagggggcca tcggcgagtt cctcgtaccg gacaacacca
     4141 ccggcgacat ggagaagggc gacccgatca aggtcaacgc cgggatcgcc cgcaccaccg
     4201 gcagggcctg agagcggacg ggagaggaga cggccaatgg aagcgaacgg ctgcggccgc
     4261 ccggccacgg gcgaggaact ccacgtctgc atgggcctca actcctgcgc gggccaggac
     4321 gccgacagga ccgccaccat ggcgggcacc ggccggtgcg ccaccgtcca gcacgtgtgc
     4381 cacggcgagg gagcatgccg ggggcagggc ggatgcggtt acgccggtga cgacttcgag
     4441 cagttccacc ccggcgaaca ggcctgctgc tacaacggca gttgcgccag ccccatcaac
     4501 gagagccggg tcttctccgg cggaccgatg aagggcagga gcgtctggca gcaggcgcgc
     4561 cgtctcttcg aggcacggat gtacgcggcg ggcaaggcgt tcggcccctc ccccgggcag
     4621 ggcgtcccgg acgagcacat ccccgcctac gaccatctca ccaccccgac ggtcggggcc
     4681 tccgacaaag tcaccgcact gttccgcgcc tccgccgaca accctcgccg gcacgagggg
     4741 gtgcggttcc cggacttgca ggccatcgcc cgcaacagcg tcggccggca cctccccggc
     4801 acggagatca ccttcaccgt ccccgacggc gactcggccc tcctgtactt caagcccgac
     4861 agcgggccgc agagtgcggc ctgcacggtc accgccgacg accaaggggt ggccacggcc
     4921 gtcccgctct acgccgggca cacggccacc gaggaccaat gggtcaccgt caccgccacg
     4981 agctccgacg gggccgcgcg gtgcgagttc catgtgaggg tcctgtcgcc cgaggggcag
     5041 cgataaagcc ggggaaggcg gccggcacgg cgacgcggac ggacaccgcg gcccgacccc
     5101 cgacacccca cctggggttc gggctcgggc tgcgggggcc gcacatcccc tacatccgcg
     5161 cgcaccggcc gcccgtcgac ttcttcgaga tcatctccga gaaccacctc cggcccggca
     5221 ccgaccgcag gcgcgtcctg gacgagatcg ccgagcacta cccgatcgtc ctccacgggg
     5281 tgtcgctgtc catcggcagc accgacccgc tcgacctcga ctacctgcgt cggctgaaac
     5341 gactggccga cgcggtggac accccgtggg tgtcggacca cgtgtgctgg accggagtgc
     5401 tcggcgtcca cacccacgac ctgctgccgc tgcccttcac cgaggaatcg ctgcgccacg
     5461 tcgtacgccg cgcccggacc gtacaggagg cgctggagcg tccgctcgcc ctggagaacc
     5521 ccagcagcta cgtggagttc cgcgcctcca ccctcaccga gtgggagttc ctgagccggc
     5581 tggccgagga agcggactgc gggctgctcc tcgacgtcaa caacgtccac gtctccgccg
     5641 tcaaccacgg ctacgacccc gaggtgtacc tcaaggccct tccgcacgac cgggtgtggc
     5701 agatgcacct ggccgggcac accgactacg gcacccacct ggtcgacacc cacgacgccg
     5761 aggtgcccga cccggtctgg gacctctacc ggctcgccgt ggagctcacc gggggtgccg
     5821 ccacggtcat cgaacgggac gacagcctgc cgcccttccc cgtcctccag gccgaactcg
     5881 acaaggccag ggcggtggcg gcggaacgcg ccggcccgga gggcgaccgt cgtgactgac
     5941 gtaccgcgct cgctcgacgc gatccagcag tggatgcaga ccgccctgct ggcacccggc
     6001 ggggccgcgc acgtggcgga ggtgatcacc gcctccgggc ggatgtcggc cgaggaacgc
     6061 ctccgcgtct accgccgggg ctaccggctc cggctgctgg gctgcatgcg cggccagtac
     6121 cccgcgatgg cacacttcct ggggcgcgag ctcttcgacg ggttcgccat ggagtacctg
     6181 gacgcgcatc cgtcccgctc ccccacgctg gacgatctcg gcgccggctt ccccgatcac
     6241 ctggcccgca cccggccgga cgccggcgcg gacgacacac cgcccgaggc gtggatcgac
     6301 ctgctgatcg acctggccag gttcgaacgg gacttcgcgg cggccttcga cgcacccgac
     6361 gccgacacca gcaccggcgc cgacaccggc acccggttct tcgaggcccg gttccccgtc
     6421 caccgctacg cggccgccgt ccggcgcggc gaggaacccg agccgcccga ggccgagccg
     6481 gtccgcctct cgctgacccg ccgtgacggg accgtcgtcg tccacgacct gaccgcgccc
     6541 cggccaccac aggccggctg acaccgctcc gtcgcgaatc ggaggaaccc catgccccac
     6601 ctcaccgccc gctccgccgt ccgggcgacc gacggcatca ccaccctcga cgaactggcc
     6661 cggcacctga cggacgcggc gcgcatcgag ctgtccacca tcccgcccta cctctacgcc
     6721 gcctactccc tcaagacctc cggctactcc cagtgggccc agggcgcgtc cgcgcagcgc
     6781 accctcatcg gcatcgccat cgaggagatg ctccacatgg ccctggtgcg caacgtgatg
     6841 gtcgccacca agtgcgagac ggtcgacggg aaggagttcc gcttctacga cacggacacg
     6901 atccccgcct accccggtga catgctgcac cgccttccgc cgctgacgct gcacacgcag
     6961 cggatctcga cggccgccat cgaggggttc atggaggtcg aactccccga gagcaagcag
     7021 cagcagaccc gcaagccctc cgacgagtac cacacgctcg gcgagctgta cgacgcgatc
     7081 ggcaagggca tcgtcgcgct gagcggtcgg atcgcgtggg ggctggacaa cacccgctgg
     7141 cggcagcagt accggcgtgg ctattggaac cagtggggcg gcccgcccaa gcccctcccc
     7201 gtcgtggacc agggcagcgc cctcgacgcg ctctacgtca tcgtcgagca gggggagggc
     7261 gccccggacg agcaggagga ctcccactac cagaagttca cccgcgtccg cgatcacgtg
     7321 gacggcatcg gcgtcgtgga cgagtccggc cagcagaagt acaccatcga cagcggggac
     7381 gaagccgtct ggccggtggt gacggacccc aaggcgacgg acttcaccgg gccggtgcgg
     7441 acgctggccg agctctccga cgccgcctac tgctacgtac tggcgctgct cgacaagctc
     7501 taccggacgc cggcggacga cccgatgggc aacgacgctg ggccggagtc cgtgcgctac
     7561 ggcctggagc gcgggttcgt cgccgccatg cagggcgttc tttcccccgt ggccggtctg
     7621 ctggtcgcga cgcccgtcgg cggcgggaag aacgcgggcc ccaccttcgg gtactacgac
     7681 ctgggtgcgc ggcccaagca ggcgctgcag gacctgtgcg tccggccgga gctgatggcg
     7741 gcctaccccc aactgggtgg cggcgacggc gtgctgcacc agatctcgct gctgcccgac
     7801 ttcacgctct agcggcccgg cggctcacgt cccgatgtcc tcgccgaact cggccacggg
     7861 ctcgtcgggc acgacgtgca tcgccgcctc ctcggcggag gccgcgccgc cgtcgatgcc
     7921 cacgtcccgg gcgaagacgt cgttgcgccg gggcggcatg gcgtcgatgg tggcggtgag
     7981 ccggccggcc cgcacgtcac cgacctcctc gtcgatcggc tcgccgtcgc cgccgggctg
     8041 atcgccgatg ccgtccccgt cgggcaccgg gaggtcgggg acctcctcgg cgagccgctg
     8101 gtcgaggctc tcgcgctccc gctgctcccg ggccgtggtc ccgtggtggc ccacgcccag
     8161 cggcttctca ggaggcgagt agccctcgtc gagcacctcg tcgagaaggt caccgtccag
     8221 ggcgttctcc aggtccagat caccggggtt gtcccggcgg tccgaacggg ccggctgata
     8281 gacctcgtca cccatcacgt cgtcggacat gatcccctac ccttcctcct cccgcgcgct
     8341 cccgggacta cggcacacct ccagtctccc ctgtccggcg gcaccgcgct cttcggaggg
     8401 cgacagcgag taagtacctt tttcaaccac cggctgttct gccacggaag gtgcggcggt
     8461 aggtgtccgg gggcacgccg accgtccggt tgaagtgccg gcgcagcgag gcggccgtgc
     8521 ccatgccggt ggcctcggcg atggcctcga cgctgtcgtc ggtggtctcc aggagctcct
     8581 gggcgcggcg gatccggtgg gcgcgcagcc agcgcagcgg agtggtgccg gtgacggcgt
     8641 tgaagtggcg ggccaggttc cgggagctca tgttggcctg gcgggcgagg tcctcgaccg
     8701 tcagcggccg gtcgagccgc cgcagcgccc aggtgaacag gccggagagc gcgtgggagc
     8761 gggggtcggg cgccggggtg gcgacgaact gggcctgtcc gccctcgcgc tggggaggca
     8821 cgaccaggcg gcgggccacg gcgttggcga cggccgagcc gtggtcgagc cggaccaggt
     8881 ggaggcacag gtccatggcc gccgccttgc ccgccgaggt gaggacgctg ccgtcgtcga
     8941 cgtagagcac gtccgcgtcg acccgtaccc cggggtattt ggcggccagg gcgggggcgt
     9001 gcagccagtg ggtggtggcc cggcggccgt ccagcaggcc ggcggcggcc aggacgaacg
     9061 cccccgtgca cagcgagacg atccgcgcgc cggcccggtg tgccgcgcgc acggcgtcga
     9121 cgagctcggc gggcggctcc tcgtcgaggt ccgcccaggc cgggacgatc accgtgtgcg
     9181 ctcgcaccag cccgtcgagc ccctcgtcgg gttcgagccg gaaccggccg ccgacccggg
     9241 ctccggcggg tccgcagacg gtgagctcgt accacgggtc ggcgaggtcg gaccggtcga
     9301 cgccgaacac ctcgcagggc gcggccagtt cgaagtggct caccccgtcg gtgacggcca
     9361 gggcgacggt agtcatgtcc gaaactgtac gaggcgtggc actcccgaca ctcgtcggcc
     9421 ccacccgcct cgggggagcc tgtcccggtc gatggatcaa gcagtcgtgg atcggcacgt
     9481 catggatcgg agagcactca tgggaacgag cggacaggtg gccgtcctcg gcgcctacgg
     9541 acacaccggg cgcttcgtgg tggccgaact cctggagcgc ggcctgcggc cggtcctctg
     9601 cggacgcgac accggccggc tcgacgcgct ggccggccgc cactccgggg tccgccccgg
     9661 gctcggcgtc cggccggcga cggtcggcga tccggcctcg ctcgaccggg cgctggccgg
     9721 cgcggacgcc gtgatcaact gcgcgggccc cttcgccggg acggcctccc ccgtgatcga
     9781 ggcggcgctg cgcgcccgga tcccctatgt ggacgtcgcg ggcgaggtgg aggccgtcgc
     9841 cgacacgttc acgcagttcg cggaacgggc ggaggccgcg ggggtgacgg tcgtcccggc
     9901 gatggcgttc ttcggcgggc tgggcgatct gctggtgacc gccgcgctgg gcgaccggcg
     9961 gtcggccgac gaggtgttcc tcgcctacgc gctgagcagc tggcacccca ccgccgggac
    10021 ccgcgcctcg tcggcggtct ccagggaacg ccgcgagggc cgtcgcctcg tgcacgcgga
    10081 cggccggctg gaactgcgga ccgacaaggc gccgaccggc cggtggtcct tcccggcgcc
    10141 ggtggggaac caggccgtgg tgcgggagtt caccacggcg gacagcgtga cgatctcacg
    10201 gcacgtcagc gtgcccgtcg tcgacacctg tatgacgtcc ggcgccgtcc aggacgtgct
    10261 ggctcccggc gcccccgctc cggcgccggt ggacgacctc ggacggtcgg cccagacctt
    10321 cctggtcgag gcggtcgtcc gctccggtgg taccgaacgc cgggccgtgg cccggggccg
    10381 ggacatctac gccgtcagcg cgcccttggc agtggaggcg gtcctgcgtg tcctcggcgg
    10441 gcgggcgagg agggccgggg tcgcctcagc cggggagttg ttcgacgcgc gggacttcct
    10501 ggcctcgctc gccccgcacg tctcggtcga gttcgctcac tgaccggtgg gcgccggcag
    10561 cacgccgtcg gccaccagcc ccgccaggac cgcctcgccc atggtgtgga cggccgaccg
    10621 gggccggacc atgaccgtga actcctcgat cctgccgtcg tcgccgaagt gcagcaggtc
    10681 gatgccgtgg atctcctttc cctccacggt ggcccggaag agcaggacgg cggaggggcg
    10741 ggtcttcccg tcggcgctcg tctccgcctc ccccgcgtag tgaccgatgt agcggaagtc
    10801 ctcgaaggtg cgcaggagga cctggaacag ggcgagcacc gtcggcttgc cctcgaacgg
    10861 ccggaacttc acggggctgt agaagcggat gtcgtccgtg aacaggtcgt ccagcgcggc
    10921 caggtcgcgg ttgtcgacg
//
