LOCUS       NZ_CP034587            23103 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces luteoverticillatus strain CGMCC 15060 chromosome,
            complete genome.
ACCESSION   NZ_CP034587
VERSION     NZ_CP034587.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces luteoverticillatus
  ORGANISM  Streptomyces luteoverticillatus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     The whole draft genome of Streptomyce luteoverticillatus CGMCC 15060
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7367863)
  AUTHORS   Feng,Z., Chen,G., Zhang,J., Zhu,H., Yu,X., Zhang,W. and Zhang,X.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-DEC-2018) School of Life Sciences, Ludong University,
            186 Hongqi Road, Zhifu Distric, Yantai, Shandong 264025, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. 2.3
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 247.0x
            Sequencing Technology             :: PacBio RSII
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003970715.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:34:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,575
            CDSs (total)                      :: 6,474
            Genes (coding)                    :: 6,276
            CDSs (with protein)               :: 6,276
            Genes (RNA)                       :: 101
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 104 of 198
            Pseudo Genes (incomplete)         :: 118 of 198
            Pseudo Genes (internal stop)      :: 12 of 198
            Pseudo Genes (multiple problems)  :: 30 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 20:02:22
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 49713
            Orig. end                         :: 72816
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP034587.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23103
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..23103
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23103
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13103]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13103
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(33..677)
                     /locus_tag="EKH77_RS00230"
                     /old_locus_tag="EKH77_00230"
     CDS             complement(33..677)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018523607.1"
                     /locus_tag="EKH77_RS00230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00230"
                     /product="hypothetical protein"
                     /protein_id="WP_126912421.1"
                     /transl_table=11
                     /translation="MSRTRITVTTLTAFLSLAAITGCSSESGDEPGKPLTKQLEQGEIT
                     QALPGPGEVLPGWEPYKDKRVTSEGQYCTEVKKDASPKGWVRGGSAWFMYNGSTDNMMD
                     VDICLFDTPENAKSAYTEWKGTEQSKEKAPKKPVGDETVFVVNPGLSENSVNGFTRSGT
                     VNIRVKIQGTGGDTTGVQDMLAATLKRLQQVQDGKRATATAGDEAAKAAKK"
     gene            complement(813..3536)
                     /locus_tag="EKH77_RS00235"
                     /old_locus_tag="EKH77_00235"
     CDS             complement(813..3536)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040347.3"
                     /locus_tag="EKH77_RS00235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00235"
                     /product="DUF6185 family protein"
                     /protein_id="WP_164737677.1"
                     /transl_table=11
                     /translation="MTAVARRAGRCTALLLACLVWSGVPPARAEGPAEARTEVRTEAPT
                     KGRTEARAEARPEARAETPAAPRTQAPTTPHGEAPAAPTPTPAAECHADQLATARTQAT
                     LRIDNRAQSVAAAIATMTIRAPTSWAHANDLLLSENSAAHQQAMRCLLRDPRDVMRPDE
                     FRPHSPQVVTEASWVKVRYDTLFQFNKGGQSRIGPWAIGVRPELWTLSLVPPPALAGAH
                     WDDVRIELGGLATSQVTPRPAQADSANLLWRDLGPPGPQGSTVTVQLVPPWQRAWVATS
                     SSSEPWLVANAAGMTTWWLGAAGIIVFAALQARRWPAGPGTTDLQDGSSTALLRWGLLK
                     AVLGVLVLLLYKMVLDSARALKIAPAWLGYELRWPVLVGFLAAWTLIATARPRNTVLAA
                     ATALTLAGGLVAAAPSLFGLPPPLVVPQSPATATDIPALLAMAAAMLWLWLAGLVLWAR
                     MLAHDGGLLRPHTSPWRLGRTGTCLTVTTLLFLGWAVWASERHWKRVSWLSDQHAPDYR
                     ARYHTFLSKDLVAFTAELPAWFYSHTWALTGIAIVALLRARDLAPRMPYASPTKLDRLL
                     LAVFFAIVVAWRQGSYAGSQLLASLWLVLDLAALYGLLAVGQRRAVLTQHFEGCPRAPA
                     LGESISETGLNDLIARARRYRELIGLLRGMDQAQHPDAPGGRHAVEKEMSRLHHWRPQG
                     GTRGSPRLWLPGEITVVDVALSWGPYARWWDNARRAALLAAVFGLPGSVILVWASYAPE
                     QVWMRQKQYFFGAPEMVWAFISWELTWAGAGLVLGALWRLLPGRRGPARALSLVIAYAL
                     LIGLGSLGNLITNQGVGNVAFGVCLMLLVLTLTGLAMDLDTFRSERRLWPSRIQLLLSI
                     YQIKSFSAQIAYVLVQVVAVLSILRFFVGPESRSLK"
     gene            complement(3595..4005)
                     /locus_tag="EKH77_RS00245"
                     /old_locus_tag="EKH77_00245"
     CDS             complement(3595..4005)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006602217.1"
                     /locus_tag="EKH77_RS00245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00245"
                     /product="hypothetical protein"
                     /protein_id="WP_240667142.1"
                     /transl_table=11
                     /translation="MGRQAEVARRVLPSFEEAEGLGPQDGAFVRDLVAVLDKHGNLDRF
                     GLCLLHDHFRLAPDEVLVETHDLDARTLQVKVEKAATTTHTRPSQWRFAKAPGKAKASR
                     NAGGADVESHVCQVVLQCSPISGCPGKKSAQR"
     gene            4395..5234
                     /locus_tag="EKH77_RS00250"
                     /old_locus_tag="EKH77_00250"
     CDS             4395..5234
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0032259 - methylation [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (60-182). E-value: 3.6e-16. Score:
                     50.2. Matches aSDomain: nrpspksdomains_EKH77_RS00250_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982088.1"
                     /locus_tag="EKH77_RS00250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00250"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_240667143.1"
                     /transl_table=11
                     /translation="MIREPEHNQRPIPPAVQEAYGADDLGTKPIFAGGFINFGHWQAID
                     ISSGLSHEDRVRSQQDMYRHILNALPPTEQRRALEVGSGTGAGTALALQEYGFAQITGM
                     DIHPRQIERAQQSNSRLLAERPEHLGFVQGAAESMPFDDEEFDFLYSVEAAQHFSDLTA
                     FGRETARVLRPGGHAVIASFFTTDDTPGHAERLAALLDCYANGLDLAHPVPHVVDALAQ
                     AGLTHTRATSIGPAVWQGWDRWINHVSGPDAWPRNFLRVHEEGILDYYVITATRPAD"
     aSDomain        4575..4940
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EKH77_RS00250_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.60E-16"
                     /label="EKH77_RS00250_oMT.1"
                     /locus_tag="EKH77_RS00250"
                     /protein_end="182"
                     /protein_start="60"
                     /score="50.2"
                     /tool="antismash"
                     /translation="DMYRHILNALPPTEQRRALEVGSGTGAGTALALQEYGFAQITGMD
                     IHPRQIERAQQSNSRLLAERPEHLGFVQGAAESMPFDDEEFDFLYSVEAAQHFSDLTAF
                     GRETARVLRPGGHAVIAS"
     gene            complement(5305..5907)
                     /locus_tag="EKH77_RS00255"
                     /old_locus_tag="EKH77_00255"
     CDS             complement(5305..5907)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676823.1"
                     /locus_tag="EKH77_RS00255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00255"
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_126912423.1"
                     /transl_table=11
                     /translation="MDGHPDTGGGAEPSDVLEVAPTARTAVAWLPPQELWPPIQDIRWE
                     HDPQVRRWPPHVNLLFGFVPEEEFVRAVPLLSAAVAESAAFTARLAGVRYFRHRSYATV
                     WLDPAAADPAAWARLHRALELRFPLCRGRGGRFTPHLSLGRTRDPQRLAAECAVRLGGL
                     SAVVEEVALLSRRGEGPMQPRAVIRLGTGEVRRTQEH"
     gene            6072..7214
                     /locus_tag="EKH77_RS00260"
                     /old_locus_tag="EKH77_00260"
     CDS             6072..7214
                     /EC_number="6.3.2.2"
                     /GO_function="GO:0004357 - glutamate-cysteine ligase
                     activity [Evidence IEA]"
                     /GO_process="GO:0042398 - cellular modified amino acid
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1165: carboxylate-amine ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF010041.0"
                     /locus_tag="EKH77_RS00260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00260"
                     /product="glutamate--cysteine ligase"
                     /protein_id="WP_126912424.1"
                     /transl_table=11
                     /translation="MHPHPAEEPPTIGVEEEFFLVHPGSRRLVAAGARVVARASAELRG
                     GVSGEFTEFQVEGRTPPCSGPQELRGELRRARAALAAAARAEGLRLCASGTPVLADDSG
                     TGTTGADIGDHPRYRAGLLQYRRLLDQFVLCAFHAHVHLPDRETAVLVSNHLRPWLPLL
                     VAMSANSPYHHGQDTGYASWRAVIRSCFPCLGPPPYAASLDEYGHLATAMAATEAMLEP
                     GMPFWDVRPNPHLPTLEVRTMDVLPDTDDTVAMTLIIRALVTTAASRVADGDPGPRVGA
                     ELLRAAYWRAARDGWPGQGLDTLTGHVLPSSEQAQRLVDDIRPALHAYGDEDEVTAFLH
                     RLRQRGSGAERQRARMTHEPHLSAVVDGCLVQETCADGCG"
     gene            complement(7263..7916)
                     /locus_tag="EKH77_RS00265"
                     /old_locus_tag="EKH77_00265"
     CDS             complement(7263..7916)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005320886.1"
                     /locus_tag="EKH77_RS00265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00265"
                     /product="2OG-Fe dioxygenase family protein"
                     /protein_id="WP_126912425.1"
                     /transl_table=11
                     /translation="MLSAEVWACLGADTASWAGFAAHWDDLVTDPYAAENGTRRLRRYG
                     IFSLTREGRLIARPNDAFVQPEASNPMYVGVDRRFEPLTDACTADPLLVSLIRLLGQVA
                     AGLEDCEEWVVQVHPFRVLASAGQDGQATPEGRHRDGVTLVSSLLIGRENATGGESSVY
                     DMAGAPVLATTLSEPGSLLLGDDRRTLHEVSPIRPLDPAQRARRDVLVTTLLPR"
     gene            complement(8925..10001)
                     /locus_tag="EKH77_RS00275"
                     /old_locus_tag="EKH77_00275"
     CDS             complement(8925..10001)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018845680.1"
                     /locus_tag="EKH77_RS00275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00275"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_126912426.1"
                     /transl_table=11
                     /translation="MPPAPLPTAQPTIVARGLCRSYPGVKAVRGVDLTVYPGETFGFLG
                     PNGAGKSTTIAMLCTLTRPTAGQARVAGADITEDPGTVRRRMGLVFQELTVDGELTANE
                     NLRFHADLYGLSKRVARARTTEMLDLVGLADRRNSLVRTFSGGMKRRLEIARGLLHSPQ
                     VLFLDEPTIGLDPLSRAQLWEHLHHVRKEQAVTLFLTTHYLDEAEHCDRIAIMDDGRIV
                     TEGTPAALKAAIGTDRIRLHTTDDRAAATALRRQFGLNATAGPDGLCTQAPDGAAFVPA
                     LCAHLGVPVLSITVTSPSLDDVFLRYTGRTIHDAEKRSGRQTPPAPRSTDTPGTRLSRH
                     PGRPWRRRKARKTRSQAP"
     gene            complement(10001..10450)
                     /locus_tag="EKH77_RS00280"
                     /old_locus_tag="EKH77_00280"
     CDS             complement(10001..10450)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024862.4"
                     /locus_tag="EKH77_RS00280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00280"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_126912427.1"
                     /sec_met_domain="PF13471 (E-value: 9.8e-23, bitscore: 79.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVAVTVDKPPRIPIHRRPLPLLAVVAGHLIGGLSPRTVRNVLTV
                     CARGARPAGYAEARRARARVVAVSVRCAGEGCLPRSIATALLCRAGGAWPTWHAGVQTM
                     PFRAHAWVEAENRPVDEPLSTTHMQPLVTVPPGGQPPPSSPAERP"
     gene            complement(10447..10701)
                     /locus_tag="EKH77_RS00285"
                     /old_locus_tag="EKH77_00285"
     CDS             complement(10447..10701)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014627213.1"
                     /locus_tag="EKH77_RS00285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00285"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_126912428.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.4e-07,
                     bitscore: 28.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 3.3e-21,
                     bitscore: 73.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.1e-14, bitscore: 51.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSLRQDISAATVEDGMVLLDERSGRYYQLNGSGALVLRILIEGG
                     GEKEAADALTEHYDVPRDRALADIGRIVRRLCGAGLMTP"
     aSDomain        complement(10453..10692)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EKH77_RS00285_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.40E-23"
                     /identifier="RREFam002.1"
                     /label="EKH77_RS00285"
                     /locus_tag="EKH77_RS00285"
                     /protein_end="83"
                     /protein_start="3"
                     /score="73.7"
                     /tool="antismash"
                     /translation="LRQDISAATVEDGMVLLDERSGRYYQLNGSGALVLRILIEGGGEK
                     EAADALTEHYDVPRDRALADIGRIVRRLCGAGLMT"
     misc_feature    complement(11015..11032)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.1"
                     /tool="antismash"
     misc_feature    11062..11075
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.64"
                     /tool="antismash"
     misc_feature    complement(11103..11118)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     gene            11141..11272
                     /locus_tag="EKH77_RS00290"
                     /old_locus_tag="EKH77_00290"
     CDS             11141..11272
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033521.1"
                     /locus_tag="EKH77_RS00290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00290"
                     /product="lasso RiPP family leader peptide-containing
                     protein"
                     /protein_id="WP_126912429.1"
                     /transl_table=11
                     /translation="MDERTEVLYEPPALTEAGDFTEKTRGGTGELQEPIFGRFNPQQ"
     CDS_motif       11141..11215
                     /prepeptide="leader"
                     /note="peptide class: lassopeptide"
                     /note="predicted sequence: MDERTEVLYEPPALTEAGDFTEKTR"
                     /locus_tag="EKH77_RS00290_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       11216..11272
                     /prepeptide="core"
                     /locus_tag="EKH77_RS00290_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class II"
                     /score="6.00"
                     /molecular_weight="1957.1"
                     /monoisotopic_mass="1955.9"
                     /core_sequence="GGTGELQEPIFGRFNPQQ"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MDERTEVLYEPPALTEAGDFTEKTR"
                     /leader_location="[11140:11215](+)"
     gene            11304..13103
                     /locus_tag="EKH77_RS00295"
                     /old_locus_tag="EKH77_00295"
     CDS             11304..13103
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="EKH77_RS00295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00295"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_126912430.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.5e-37, bitscore:
                     128.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHWFVVLPDCVAAQAVPRMLSGAALLASHASGRPWLIGRIPAEQR
                     TVLTAGDQRLAVLGQSPGTAGHLMRLAQRVRGPRGLSFPTDALPGSAHLVLSVNGHVRA
                     QGTASGLRRVYRTTWQGVTVAADRADVLAELTGAELDDRWLATTLLTSELPHPLNVRSP
                     WRRIEAVPPGSALLITPDGRARLHRWWQPPAPVRSLAEGAPAVREALSAAVSARVNTLG
                     AGQPLGCDLSGGLDSTSLCFLAHRFGAARLVTMTVQLRDPSNDDVLWADRAALSLPLAT
                     RLVLHSQALPAQYAALEQAPSVTDAPSLLLRSRAVLDVCAQRYACHRVTVHLAGHGGDE
                     VLQAPPSYLRDLLRRDPLLVLRHSRGHRAHYRWPLSRMLHGLADRRSYARWLADETHLL
                     QAPDTASPPLGWGPPLRMAPWATPRAVKAVAFLLEEAAHRAEPLAPERSRHQALHRIHT
                     ASQLYRLMRQDLAEPWIALPYLDDHVLEACLAVRPDERGTPWRYKPLLAAALDGIVPTA
                     LLNRTTKAGSGSDFYRGLRQHRRQLLDLVDQSQLAQRGLIDPVPLRAALLTPCSRTVQA
                     LENALAVEHWLAYLPPRPCPTHA"
     gene            13469..13822
                     /locus_tag="EKH77_RS00300"
                     /old_locus_tag="EKH77_00300"
     CDS             13469..13822
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569699.1"
                     /locus_tag="EKH77_RS00300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00300"
                     /product="beta/gamma crystallin domain-containing protein"
                     /protein_id="WP_126912431.1"
                     /transl_table=11
                     /translation="MVSKTKKVVRSAAVAFAAAATITMTVPAGDAFAIDHIPCRGGENF
                     LKIWSHNGGSQSVDCYANRGRTDFGGWWVDKISTGNNDLIYYDANGDSVKIERWHEITF
                     PNRPPKVNSIEIL"
     misc_feature    complement(13954..13969)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.6"
                     /tool="antismash"
     gene            14521..15381
                     /locus_tag="EKH77_RS00305"
                     /old_locus_tag="EKH77_00305"
     CDS             14521..15381
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /GO_process="GO:0007155 - cell adhesion [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129584.1"
                     /locus_tag="EKH77_RS00305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00305"
                     /product="leishmanolysin-related zinc metalloendopeptidase"
                     /protein_id="WP_126912432.1"
                     /transl_table=11
                     /translation="MVEYETHYARADAGRARELAATTSPYTIKVQFLGGLNSTQKAAFT
                     KAADRWAKVIVGDLPDVSVDGEVIDDLLILAQGTSIDGPGNILGEAGPTVLRPANGPGA
                     FLPAKGTMSFDTDDLEEMAANGTLVDVITHEMGHVCGIGTRPWTEKNLLQGAGGDNPVF
                     RGTSAMEEYGKLVGAGQPRPVPVENQGGPGTRDGHWRETVFANELMTGFVGGAPNPLSR
                     LTVGSLNDLGYVVDMAAADEYALPNHLELAERGELRTHAAPVGAGTVQRTIPVILPEDS
                     LLASA"
     gene            15532..15759
                     /locus_tag="EKH77_RS00310"
                     /old_locus_tag="EKH77_00310"
     CDS             15532..15759
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EKH77_RS00310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EKH77_00310"
                     /product="hypothetical protein"
                     /protein_id="WP_126912433.1"
                     /transl_table=11
                     /translation="MRPAPNRFSHVLEEMHPYWFERSEQAPQPDGMLPAGTPVLLLREE
                     GDHCRVVTGTGLYVTVARVNLRKLPGDGDG"
     gene            <16069..>16215
                     /locus_tag="EKH77_RS00315"
                     /old_locus_tag="EKH77_00315"
                     /pseudo=""
     CDS             16069..>16215
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126802.1"
                     /locus_tag="EKH77_RS00315"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="EKH77_00315"
                     /product="ABC transporter permease"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLVVALGLALGIALVITVTSVSAGMAKAQDKVLQSLYGLGTDMTV
                     TKAQ"
     gene            complement(16476..16700)
                     /gene="infA"
                     /locus_tag="EKH77_RS00320"
                     /old_locus_tag="EKH77_00320"
     CDS             complement(16476..16700)
                     /GO_function="GO:0003743 - translation initiation factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006413 - translational initiation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="infA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675926.1"
                     /locus_tag="EKH77_RS00320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00320"
                     /product="translation initiation factor IF-1"
                     /protein_id="WP_126912434.1"
                     /transl_table=11
                     /translation="MTKTAKGIEVEGTVTECLRNATFKVELKNGHTVLAHISGKIRKNY
                     IKILPYDRVLVELSPYDLTRGRILYRYRA"
     gene            complement(16756..17553)
                     /locus_tag="EKH77_RS00325"
                     /old_locus_tag="EKH77_00325"
     CDS             complement(16756..17553)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018538072.1"
                     /locus_tag="EKH77_RS00325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00325"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_126912435.1"
                     /transl_table=11
                     /translation="MNITHSISGTGDHTVAVTRVSDTQWHAMEDDRVVGRGDASRRPDG
                     RLFISIDAWHSAVFDRIADAMLTDLRTPLYTVVDEADHDSRSAWERAGFAAARREWGYL
                     VPTDPQVTGLGSPRLPSGVTIVPAGEAEEGPLRALDRVIRDEVEAAAGWRTMPTEVLPR
                     PAGTTVVDPSKYTVARHFDQYVGLIRVAPLPRQPRIGLIAVRTDSHRRGIARALLAHAL
                     GSLHRSGTASAWAEVSESNAAATALFESIGARRAAATLELVRR"
     gene            17929..19164
                     /locus_tag="EKH77_RS00330"
                     /old_locus_tag="EKH77_00330"
     CDS             17929..19164
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004950313.1"
                     /locus_tag="EKH77_RS00330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00330"
                     /product="xylan 1,4-beta-xylosidase"
                     /protein_id="WP_240667677.1"
                     /transl_table=11
                     /translation="MDDQGGAQLGWGFTHTQYSADHGVPDATRRAGALLSGQPMPQNQH
                     LMGWGAENPEPAPGRYDFEALDQRVELMRATGAAPVLTLCGAPDWMKGGRKGRTDWSRL
                     EAAPDPRHFADFARLAGVVARRYPDIRHFLVWNELKGFYDEDKRRWDYEGYTELYNLVH
                     AELKRQNPECLVGGPYVVVDHEPPGDEDGSPEVRGAWGALDRRSVDVIRYWNKYKVGAD
                     FVVVDGASYTREGHRTIPDEFAATEKFTDVTRWLRNVTGLPVWWAEWYVEPPAEDDRAG
                     GRDGWSEQHRAAVQATAMTRLALGGAATALYWNPQRIEGDCPGCLWRSTHLDDGGGGLP
                     MARLLGWFAREFPPGTVFRRVAVSAEAGARIHVLAHESVVLVVSTERRQVMASVDGQEL
                     TLAPYEVRWLDG"
     gene            19200..20306
                     /locus_tag="EKH77_RS00335"
                     /old_locus_tag="EKH77_00335"
     CDS             19200..20306
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566099.1"
                     /locus_tag="EKH77_RS00335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00335"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_126912437.1"
                     /transl_table=11
                     /translation="MDFAHALARREELSESEPGPLPVPSGAPPLDPELGAALEALGHVV
                     REPITPENLAARQERDAAVRPRPTVRDLRDDGRFEVEELRVPGASGGPDVTLVSARPAG
                     IDRARPLPLLYYMHGGGMISGNAWSVLPRLLREWACALELVVVSVEYRLAPQARYPGPV
                     EDCYAGFVWVAAHAAELGIDAGRIVIGGKSAGGGLAAALALLVRDRGGPAPIGQLLLCP
                     MLDDRNDTFSSHQMAGVDVWDRTSNATAWQALLGDRYGAADLSPYAAPARATDLSDLPP
                     AYVEVGSAETFRDEGVAYANAIWQAGGQAELHVWPGAFHGFDTFAPQAALSQDARDARF
                     RWLRRVLTQSTQSTPSTQSGASSGPGSV"
     gene            complement(20329..>20511)
                     /locus_tag="EKH77_RS00340"
                     /old_locus_tag="EKH77_00340"
                     /pseudo=""
     CDS             complement(20329..>20511)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019359616.1"
                     /locus_tag="EKH77_RS00340"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00340"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GKVVCFFRSAEKFKARYATLGFSDQAKLDDGPMWAAGFALTEVTA
                     EVEARISALVKRAVS"
     gene            complement(20565..22145)
                     /locus_tag="EKH77_RS00345"
                     /old_locus_tag="EKH77_00345"
     CDS             complement(20565..22145)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004941409.1"
                     /locus_tag="EKH77_RS00345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EKH77_00345"
                     /product="MFS transporter"
                     /protein_id="WP_126912438.1"
                     /transl_table=11
                     /translation="MRKWWPLVAVSLGAFILLVDVTIVNVALPQMAEALDAPFSSLQWV
                     VDAYALSLAALLLAAGSIADLFGHRKLYVSGLALFALASLACGLAPNAGVLVAARAVQG
                     AGGAAMFATSAALLGATYQGRDRGTAFGIWGAVNGAAAATGPILGGLLTEHIGWQAIFL
                     VNLPIAAVAILLTLRVVRADRTARPQARTGRVDIPGAVAFTLAAAAVTYGLIRSAETGW
                     TSPTVIISFAVAAASLIAFVLVETRLGRRGGQPMLDLALLRRPSFAGLMGGALLLQGGA
                     FGCLVLVSLWLQSVLGLGPVEGGLALTPMAVVSFLVAAIAGRHIQRLAPRLPIGIGLLL
                     IAAGMYLLYDAMSADATASSLAIGLAVSGAGVGLATPVLVSAATGSVPPQRMGMAAGAV
                     NTFRQLGMTLAIAVLGAVFTHTAQKRLSGLVPDAHEAASALAGGQAQRLVAAAPHGSQA
                     EARELIHRVFADGMQDVFLCAAAAAAVGGLLVLALVRPTPTHPAPGTPGAAGPAGSAEP
                     AEEPATVGQ"
     misc_feature    complement(23025..23039)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.48"
                     /tool="antismash"
ORIGIN
        1 accgtcatgg ccaccggtgt acccgttgcg ggttacttct tcgcggcctt ggccgcctcg
       61 tcccccgctg tggctgtggc gcgcttgccg tcctggacct gctgcaggcg cttgagcgtc
      121 gcggccagca tgtcctggac gccggtggtg tcgccgccgg tgccctggat cttcacccgg
      181 atgttgacgg tgccggagcg ggtgaaaccg ttcaccgagt tctcgctcag gcccgggttc
      241 acgacgaaca ccgtctcgtc ccccaccggc ttcttgggag ccttttcctt gctctgctct
      301 gtgcccttcc attcggtgta ggcgctcttg gcgttctcag gtgtgtcgaa caggcagatg
      361 tctacatcca tcatgttgtc ggtggagccg ttgtacatga accacgcgct gccgccccgc
      421 acccagccct tgggcgaggc gtccttcttc acctccgtgc agtactgccc ctccgaggtc
      481 acgcgcttgt ccttgtaggg ctcccagccg ggaagcacct cgccggggcc ggggagagcc
      541 tgggttatct cgccctgttc gagctgcttg gtgaggggtt tgcccggctc gtccccggac
      601 tccgaggagc agccggtaat ggcggccagg ctgagaaacg ctgtgagggt ggtgacggtg
      661 atgcgcgtgc gtgacatgga catatcttac ggacggtggc cggtgagaag atcaaccgga
      721 tccggagccg ggcgccctgt cgtagctgtc gcgtccgtgg gcggtcgacg acgggtgccc
      781 gggggaaggc ggtcacttcg cggttgcttc ggctacttca gcgatctcga ctcggggccg
      841 acgaagaacc tcagaatgga cagcaccgcg accacctgaa ccagtacgta ggcgatctgc
      901 gcggagaagc tctttatctg gtagatcgac aggagcagtt ggatgcggct gggccacagg
      961 cggcgttccg agcggaaggt gtccaggtcc atggcgaggc cggtgagggt gagtaccagg
     1021 agcatgaggc agacgccgaa ggccacgttg ccgacgccct ggttggtgat gaggttgccc
     1081 aggctgccga ggccgatcag cagggcgtag gcgatcacca ggctcagggc gcgggccggg
     1141 ccgcggcggc cggggagcag ccgccacagg gctccgagta ccaggcccgc gcccgcccag
     1201 gtcagttccc aggagatgaa ggcccagacc atctcggggg cgccgaagaa gtactgcttc
     1261 tggcgcatcc acacctgctc cggcgcgtag gaggcccaga cgaggatgac gctgccgggc
     1321 aggccgaaga cggcggccag gagggcggcc cgccgggcgt tgtcccacca tctggcgtac
     1381 ggtccccagc tcagggcgac gtccacgacc gtgatctcgc cggggagcca cagccgcggg
     1441 gagcctcggg tcccgccctg gggccgccag tggtgcaggc ggctcatttc cttctccacc
     1501 gcgtgtctgc cgccgggggc gtccgggtgc tgggcctggt ccatgccgcg caggagacca
     1561 atcagttccc ggtagcggcg ggcacgtgcg atgaggtcgt tgaggccggt ctcgctgatc
     1621 gattcgccca gtgccggggc gcgagggcag ccctcgaagt gctgggtgag gacggctcgt
     1681 cgctgcccga ccgccagcag tccgtacagc gcggcgaggt ccagcaccag ccagaggctg
     1741 gcgagcagct ggctgccggc gtaggagccc tggcgccagg ccaccacgat ggcgaagaag
     1801 acggccagca ggagccggtc cagtttggtg gggctcgcgt agggcatgcg tggcgcgagg
     1861 tcccgggccc tgaggagggc cacgatggcg atgccggtca gcgcccaggt gtgggagtag
     1921 aaccaggcgg ggagctcggc ggtgaaggcc accaggtcct tgctgaggaa ggtgtggtag
     1981 cgcgcccggt agtccggggc gtgctggtcg ctgagccagc tgacccgttt ccagtgacgt
     2041 tcgctcgccc acaccgccca gcccaggaac agcagggtgg tgacggtgag gcaggttcct
     2101 gtgcggccta gccgccaggg ggaggtgtgg ggccggagca gtccgccgtc gtgggccagc
     2161 atgcgggccc acagcaccag tccggcgagc cagagccaga gcatggccgc ggccatcgcc
     2221 aggagggcgg ggatgtccgt tgcggtggct gggctttggg ggacgacgag tggcgggggc
     2281 agaccgaaca gggacggtgc ggcggccacc aggcctccgg ccagggtcag cgcggtggcg
     2341 gccgccagta cggtattcct ggggcgggcg gtggcgatga gggtccaggc ggcgaggaag
     2401 ccgacgagga caggccagcg gagttcgtac cccagccagg ccggcgcgat cttcagtgcc
     2461 ctggcgctgt cgaggaccat cttgtacagg aggaggacca gcacaccgag cacggccttg
     2521 agcaggcccc agcgcagcag ggcggtgctg ctgccgtcct ggagatcggt ggtcccgggg
     2581 ccggcgggcc agcggcgggc ctggagggcg gcgaagacga tgatgcccgc ggcgcccagc
     2641 caccaggtgg tcatcccggc cgcgttggcc accagccacg gttcgctgct ggagctcgtc
     2701 gccacccagg cgcgttgcca tggggggacc agctggaccg tcaccgtgga accttgtggc
     2761 ccgggtggtc cgaggtcgcg ccacagcagg ttcgcgctgt ccgcctgcgc cggccggggc
     2821 gtcacctgtg aggtggccag gccgcccagc tcgatccgta cgtcgtccca gtgcgcgccc
     2881 gccagcgccg ggggcggcac gagcgagagg gtccacagct cgggccgcac gccgatcgcc
     2941 catggcccga tccgggactg cccgcccttg ttgaactgga agagggtgtc gtagcgcacc
     3001 ttgacccagg acgcctcggt gaccacctgt gggctgtgcg ggcggaactc gtcgggacgc
     3061 atgacgtccc tcgggtcccg cagcaggcag cgcatcgctt gctggtgggc ggcggaattc
     3121 tcgctcagca gcaggtcgtt ggcgtgcgcc caggaggtgg gggcccggat ggtcatcgtc
     3181 gcgatggccg cggccacgga ctgggcgcgg ttgtcgatgc gcagcgtggc ctgtgtgcgg
     3241 gcggttgcca gctggtcggc gtggcattcg gcggcggggg tgggagtagg ggcggcgggg
     3301 gcttccccat ggggggtggt gggggcctgg gtgcgggggg ccgcaggggt ttcggcgcga
     3361 gcttccggac gggcttcggc gcgggcttcc gtacggccct tggtgggggc ctccgtgcgg
     3421 acctccgtcc gggcctcggc ggggccctcc gcgcgggcgg gagggacgcc tgaccacacc
     3481 aggcaggcca gcagcagcgc cgtacaccgc cccgcccggc gggccacggc ggtcatcgcc
     3541 gccgacggcc gtccgggcac cggcccgggc ggccggcagg agcggtgggt ggcctcaccg
     3601 ctgcgcgctc ttcttccccg gacatccact gatcgggctg cactgcagca ccacctggca
     3661 gacgtggctc tcgacgtcgg cgccaccggc gttccgggat gccttcgcct ttcccggtgc
     3721 cttcgcgaag cgccactggg aaggcctggt gtgcgtggtc gtggcggcct tctccacctt
     3781 gacctgcagg gtacgagcgt cgaggtcgtg ggtctcgacc agcacttcgt cgggggcgag
     3841 gcggaagtgg tcgtgcagca ggcacaggcc gaaccggtcg agattgccat gcttgtccag
     3901 caccgccacg aggtcgcgca cgaaggcgcc atcctgcggt cccagccctt cggcctcctc
     3961 gaacgaggga agcactcgac gcgcgacttc ggcctgtcta cccatgatta gcctccttgg
     4021 cgacgctttg ttcttgatgg atgtaatgcg cggaattagc gtaatcatgc atatgtatgc
     4081 ctgcaatcca gagggtgcct ggggttggtc cggcgaccgc tgcgccggtg ttccacgggc
     4141 cgtgggctcg acggccatag cccttatggc cgtcatcctg atgggcgggc agggcgaccg
     4201 cccccggcca cctgaacgcc gctctgcgca gaacgtgtac ttcccgaggc catgcccacg
     4261 ggcatcgctg acctcaagag ccgcaaaagg acaggcggac acccgctcat ccgcgtcatt
     4321 agactgcgac ccgctccctg ccacatatct gatgcgtgaa gggcgatacg ccctgccccg
     4381 aggaggcacc ggaattgata cgagagcccg agcacaacca gcggccgatc ccacccgcgg
     4441 tgcaggaggc ctacggagcg gacgacctcg gcaccaagcc catattcgcc ggaggattca
     4501 tcaacttcgg ccactggcag gccatcgaca tcagctccgg cctctcccac gaggaccgcg
     4561 tccgcagcca gcaggacatg taccggcaca ttctgaacgc cctgccgccc actgagcagc
     4621 ggcgggcgct ggaggtcggc tccggcaccg gggccggtac cgcgctggcg ctccaggagt
     4681 acggcttcgc gcagatcacc ggcatggaca tccacccccg acagatcgag cgagcgcagc
     4741 agtccaactc ccgtctcctg gcggaacggc cggagcacct cggcttcgtc cagggcgcgg
     4801 ccgagagcat gcccttcgac gacgaggagt tcgacttcct ctacagcgtc gaagccgccc
     4861 agcacttcag cgacctgacc gccttcgggc gcgaaacggc ccgtgtgctg cggcccggcg
     4921 gacacgccgt gatcgccagc ttcttcacca ccgacgacac acccggtcac gccgaacgcc
     4981 tcgccgcgct cctcgattgc tacgccaacg gcctcgacct cgcccacccc gtcccccacg
     5041 tcgtcgacgc cctcgcccag gccggactga cacacacccg ggccacatcg atcggaccag
     5101 ccgtatggca gggctgggac cgctggatca accacgtctc aggacccgac gcgtggcccc
     5161 gcaacttcct ccgcgtccac gaagaaggca tcctcgacta ctacgtcatc acagccaccc
     5221 ggcccgcgga ctgaacaacc gccgcaccac tcccccgccc ccgggcggcg tccggcagcc
     5281 cccggctcgc gcggcccgtg tcttctagtg ctcctgtgtc cggcggacct cgcccgtacc
     5341 cagcctgatc acggcacgcg gctgcatcgg cccctcacct cgcctggaga gcaaggccac
     5401 ctcctcgacc accgcggaca acccaccgag ccggacggcg cactcggcgg ccagccgctg
     5461 cgggtcccgg gtgcggccga gcgacagatg cggggtgaag cggccaccac gaccgcgaca
     5521 cagcgggaat cgcagctcca gcgcccggtg gagccgggcc cacgctgccg ggtccgcggc
     5581 ggccgggtcg agccacaccg tcgcgtagga ccggtgccgg aaataccgca cacccgccag
     5641 acgcgccgtg aacgccgcgc tctccgccac tgcggcggac agcagcggca cagcccgtac
     5701 gaactcctcc tccggcacga acccgaacag cagattcacg tgcggtggcc accgccggac
     5761 ctgcggatcg tgctcccaac ggatgtcctg gatcggcggc cagagctcct gcggtggcag
     5821 ccaggccacc gccgtccggg ccgtcggcgc cacctcgagc acgtccgagg gctcagcccc
     5881 accaccggta tccgggtgtc cgtccacagt gtcatgatcc gtgctccgct caacccggtg
     5941 gcggcctggg tgggccagcc gggtcaacgg ttcgcaaagg gagccgggtg acggccggcc
     6001 gatcgcggct tccgccgcca gggcaccggg gtgagggcga caactccgtg ggggcaggtg
     6061 atcctggagc cgtgcaccct caccctgcgg aggagccacc cacgatcgga gtggaagagg
     6121 agttcttcct cgtccatccc ggcagccgcc gcctggtggc ggccggcgcg cgggtggtcg
     6181 cgcgtgcctc ggcagagttg cggggaggtg tctccggaga gttcacggag ttccaggtcg
     6241 agggcaggac accaccctgc tccggcccgc aggagctgcg cggggagctg cgtcgtgccc
     6301 gggcggccct ggcggccgcg gcgcgagccg aaggcctgcg cctgtgcgcg tccggcacac
     6361 cggtcctcgc tgacgacagc ggtaccggca cgacgggtgc ggacatcggt gaccaccccc
     6421 gctaccgcgc cggactcctg cagtaccgca ggctgctcga ccaattcgtt ctgtgcgcct
     6481 tccatgcaca cgtacacctg cccgaccggg agacggccgt cctggtgagc aaccacctgc
     6541 ggccctggct gccactcctg gtggccatga gcgccaactc gccctaccac cacggccagg
     6601 acaccggcta cgccagctgg cgcgcggtga tccgcagttg cttcccctgc ctgggcccgc
     6661 caccgtacgc cgcgtcgctc gacgaatacg gacacctcgc caccgcgatg gccgccaccg
     6721 aggcgatgct cgagcccggc atgcccttct gggacgtacg gcccaacccg cacctgccca
     6781 ccctggaggt acggaccatg gacgtactgc ccgacaccga cgacaccgtg gccatgaccc
     6841 tgatcatccg cgccctcgtc accaccgcgg catcccgcgt ggcagacggc gatcctggcc
     6901 cccgcgtcgg cgcggaactg ctgcgcgcgg cctactggcg cgccgcgcgg gacggctggc
     6961 cgggccaggg cctggacaca ctcaccggcc acgtactgcc ctcctcggaa caggcacaaa
     7021 ggctcgtcga cgacatacgc cccgcattgc acgcctacgg cgacgaggac gaagtcacag
     7081 cattcctgca ccggctgcgg cagcgcggct cgggagccga gcggcagcga gcccggatga
     7141 cccacgagcc gcacctgagc gcggtggtgg atggttgcct ggtgcaggag acgtgcgcgg
     7201 acggctgcgg ctgaccggcc ggcggtctga tgggctccgt ggtgggatgg gctccgtggt
     7261 ggtcagcgcg gcaagagcgt cgtcaccagg acgtcacgac gtgcccgctg cgccgggtcc
     7321 agcggtcgga tcggcgagac ctcatgcagg gtgcgccggt cgtcaccgag caaaagactg
     7381 cccggctcgc tcagcgtcgt cgccagcacc ggcgcaccag ccatgtcgta caccgagctc
     7441 tcaccacctg tggcgttctc acggccgatc aacagcgacg aaaccagcgt gacaccgtca
     7501 cgatgccgcc cttcgggagt ggcctgcccg tcctgaccgg ccgaggcgag cacccggaac
     7561 gggtgcacct gaaccaccca ctcctcgcag tcctccagac ctgcggccac ctgccccagc
     7621 aaccggatca gggacaccag cagaggatca gcggtacagg catcggtcaa cggctcgaaa
     7681 cgccggtcga ccccgacata catcgggttg ctcgcctccg gctgcacgaa cgcgtcgttc
     7741 ggccgggcga tcagacgccc ctcccgcgtc agggagaaga tcccgtagcg gcgcaggcga
     7801 cgcgtgccgt tctccgccgc gtacgggtcg gtcaccaggt cgtcccagtg ggcagcgaat
     7861 cccgcccagc tcgccgtgtc cgcacccaga cacgcccaca cctcggcaga cagcatcgaa
     7921 cacacccccg ccgaagacag ggaccgccca gccgcagcga tcgacgacac cgtgtgtcgt
     7981 cctaccggtg accacgtccc ccatcgtccg ccctcccccc acccaccgca tccgcacgcg
     8041 actcggacgc gacgcccacc ggcgatcagc ggggcgagag aagcgacggg cggcaagggt
     8101 aagtgctgcc aagccgatcg tgacggtgat cgcgagttcc acggcggtgg acggctgcca
     8161 acccgtcggc caggtgatcg ctccggcggc tgtcggccct gaaacatgcg ccgcgacagc
     8221 gtggcggagg aggtcgactg tgtaggtcat ggggttgacc aggcagagtg ccgcaagcca
     8281 ggcaggcagg tcggccaagg ggaacatggc tccggagagg aagaccatcg gtgtcagggc
     8341 gaagctcatc acggcctgga aggtctgtat gcgggtgata cagacggcag caaggctacc
     8401 gagggctgtc aacgtcagtg cagtgacggc cagctcgccg atgagggtgg cgatcagagc
     8461 cggcctgtag ggcacgtgag cggtccaggc gaggctgagg acgacgaggc cctggcagct
     8521 cgccacggtt gctccgccca ggcatttgcc caggagcagg ctgctgcgcc ggacgggggc
     8581 gacgagcatt tcgcgcagga agccggtctc gcagtcccag atgatggatg cgccggcggc
     8641 gacggcgggc atctgcacgg tcatcaccag cacgccgggg aagaggtatg cgcggtagtc
     8701 acccgtcccg gtgggggtgg cgacgagggc gttgaggcct gtcccgagta ccagcaacgt
     8761 gagggccggt tgcagcaggt tcatggccat caggctccgg ttgcgcaaga aacggatcat
     8821 ttcgcgctgc cagacgacct ttacggcgcg cagctctccg gagagtctcc gcttggccgg
     8881 gggtggctcc gaggtggtga tgtggggagc gtgagcggtc gtggtcatgg tgcttggctc
     8941 cgtgtttttc gtgcttttcg tcgtctccaa ggtctccctg gatgtcgtga cagccgggtg
     9001 ccgggggtgt ctgtcgaccg gggtgccggg ggtgtctgtc gaccggagcg cttttcggcg
     9061 tcgtggatgg tgcgtccggt gtatcgcaga aatacgtcgt cgaggctggg gctggtcaca
     9121 gtgatcgaca ggaccggcac gccgaggtgg gcgcacagtg ccggtacgaa ggccgcgccg
     9181 tcgggcgctt gggtgcacag tccgtcgggt ccggcagtgg cgttgaggcc gaattgccgg
     9241 cgcaaagcgg tcgccgccgc tcggtcatca gtggtgtgga gacggattcg gtccgtgccg
     9301 atcgcggctt tgagcgcggc tggtgttccc tcggtgacga tacggccgtc gtccatgatg
     9361 gcgatcctgt cgcagtgctc ggcctcgtcc aggtaatggg tggtcaggaa gagggtgacg
     9421 gcctgctctt tgcgaacgtg gtgcaggtgt tcccacagct gtgcccggga cagcgggtcc
     9481 aggccgatgg tgggttcgtc caggaacagc acctgtggcg agtgcagcag gccccgggcg
     9541 atctccagtc gtcgtttcat gccgccggag aaggtacgga caagactgtt ccggcgatcg
     9601 gccaggccca ccagatcgag catttcagtc gtcctggctc gtgcgacgcg tttcgatagg
     9661 ccgtagagat cggcgtggaa ccgcaggttt tcgttcgctg tgagctctcc gtcgacggtg
     9721 agttcctgga agaccagtcc catgcggcgg cgtaccgtgc cgggatcctc ggtgatgtcc
     9781 gctcctgcca ctctcgcctg gccggcggtg ggccgggtaa gagtgcacag catggcgatg
     9841 gtggtggact tgcccgcacc gttgggaccg aggaacccga aggtttctcc cgggtacacg
     9901 gtgaggtcga ccccgcgcac cgctttcacc cctgggtacg acctgcacag gccacgggcg
     9961 acaatcgtcg gctgagccgt cggcaagggg gcgggaggca tcaggggcgc tccgccgggc
    10021 tcgacggagg cggttggcct ccgggcggga cggtgaccag tggctgcatg tgggtggtgg
    10081 aaagcggctc gtcgacgggg cggttttccg cctcgaccca tgcgtgggcc cggaaaggca
    10141 tggtctgcac tcccgcgtgc caggtaggcc acgcaccacc ggcccggcag agcaaggcgg
    10201 tcgcgatgga cctgggcaga cagccctctc cggcgcagcg cacgctgacg gcgaccaccc
    10261 tcgcacgcgc ccttctcgcc tccgcataac cggccggtcg ggcgccgcgt gcgcaaacgg
    10321 tgaggacgtt gcggaccgtg cgcggtgaca gtcccccgat caagtggccc gcgacgactg
    10381 cgagcagtgg cagcggtcga cggtggatcg ggatgcgtgg cggcttgtcc acggtgacgg
    10441 ccacgctcat ggtgtcatca gtcctgcgcc gcagagccgg cggacgattc tgccgatgtc
    10501 ggccaacgcc cggtctctcg ggacgtcata gtgctcggtg agggcatcag cggcttcctt
    10561 ctcgccaccg ccctcgatca gaatgcggag aaccagggca ccgctgccgt tgagctggta
    10621 atagcggcca ctgcgttcgt ccagcaacac catgccgtct tcgacggtgg ccgcggaaat
    10681 atcctgtctc aggctgggca tccgtccacc tcctcctcac cgaggctttc gggtcgatgc
    10741 accgaaccta cgtctcgccc ccgaacatcg tctcctgaaa gaggagaaaa gaagggggca
    10801 ggatggtggg acaaccgaga gttcccggga tcagagcgtg cggttcgtcg aagattcttt
    10861 aaatagcgcc gacggaatgc cacccgaatg gctcagcctc caggtgcgcc ggtgaactca
    10921 ggagacgcgg ggtccacgga acctgtttgc gttgggagct gacggtctca gtcgcatgcc
    10981 gatcacgaaa caaagccccc atcggatctc acccttcaca tacccgtaac ccttttgagg
    11041 gattcccagg gcatgctatg gctttctcgc aaaaaaggcg gacagtgcgc tacaggcaag
    11101 acgagacagt ctcgtgacgc cgaaccagga ggtgttttcc atggacgagc gcaccgaggt
    11161 tctgtacgag ccgccggcgc tgacggaagc cggggatttc acagagaaga cccgcggggg
    11221 gaccggcgaa ctccaggaac cgattttcgg tcgtttcaac ccccagcagt aaggctgatc
    11281 accttttccc acgtgagggc accgtgcact ggttcgtggt tctcccggat tgcgtcgcgg
    11341 cccaggccgt tcccaggatg ctgagtgggg cggccttgct cgcctcacac gcctccggtc
    11401 gtccgtggct gatcgggcgg ataccggcgg agcagcgcac cgttctcacg gccggcgatc
    11461 aacggctggc ggtgctcggg cagagcccgg ggaccgccgg ccacctcatg cggctggccc
    11521 agcgggtgag agggccgagg ggcttgagct tcccgaccga cgcgctgccg ggaagtgcgc
    11581 acctggtgct gtcggtcaac ggccatgtgc gcgcccaggg cacggcttcc ggactgcgcc
    11641 gggtctaccg caccacgtgg caaggggtga cggtggccgc cgaccgggcc gatgttctcg
    11701 cggagttgac gggagccgaa ctggacgatc gctggctcgc gactacattg ctcacgtccg
    11761 agctgcccca tccgctcaac gtccgctccc cttggcggcg gatcgaggcc gtcccgccgg
    11821 gcagcgccct gctgatcaca ccggatgggc gggcgcgact acacaggtgg tggcagccgc
    11881 ccgctccggt gcggtcgctc gccgaggggg caccggcggt gcgagaagct ctgtcggcgg
    11941 ccgtcagcgc gagggtgaac acgctcgggg ccgggcaacc actcggttgc gacctgtccg
    12001 gagggttgga ctccacctcg ctgtgtttcc tcgctcatcg cttcggcgcc gcccgcctcg
    12061 tgacgatgac ggtacagctg cgcgacccga gcaatgacga cgtcctctgg gccgaccgtg
    12121 cagcgctcag tcttccgctt gccacccggc tcgtcctcca ctcgcaggcg ctgcccgccc
    12181 agtacgccgc gctcgagcag gcgccttcgg tgaccgatgc tccctcgctg cttctgcgga
    12241 gccgcgctgt cctcgacgtc tgtgcccagc ggtacgcctg tcaccgtgtc acggttcact
    12301 tggccggtca cggcggcgac gaagtgctcc aggcgccgcc cagttacctc cgagacctac
    12361 tgcgccgtga tccgctgctg gttctgcggc actcgcgggg acaccgcgcc cactaccgat
    12421 ggccgctgtc ccgaatgctg cacggactgg ccgaccgccg ttcgtacgct cgctggctcg
    12481 ccgacgagac acatctcctc caggcgcctg atacggccag cccacctctc ggctggggtc
    12541 ctccgctgcg catggcgccc tgggcgacgc cacgggcggt gaaggcagtc gccttcctcc
    12601 tggaggaagc cgctcaccgg gccgagcccc tggcccccga acgcagccgg catcaggcac
    12661 tccaccgcat ccatacggcg agccagctct accgtctgat gcggcaagac ctggccgaac
    12721 cgtggatcgc cctcccttac ctggacgacc acgtgctcga agcctgcctc gcggtacggc
    12781 cggacgaacg cggcacgcca tggcgctaca agcctctgct cgccgcagcg ctcgacggca
    12841 tcgtgcccac ggccctgctg aaccgcacca ccaaggccgg cagcggatcc gacttctacc
    12901 ggggactgcg tcagcatcgt cggcagcttc ttgatttggt ggaccagtcc cagctcgcgc
    12961 aacgcgggct gatcgaccct gtcccgctgc gggcagcgct gttgacgccc tgctcccgga
    13021 ccgtccaagc cctggagaac gctctggccg tcgagcactg gctcgcgtac cttcctccgc
    13081 gcccctgccc gacccacgcg taggcctgcg cggcaggaac acccgaccgg ctgtatcgaa
    13141 gcgaatggca gggtgctgac gtcgccgtcc tcgtatcgcg ccgttcagcg tcttgtggcg
    13201 acggtagtca cggtcgcccg acacacaaac atgaacctgt caattcccgc gtggggccga
    13261 tctggacatt cggggaagag tttcagccgg gggtcatgac gatggttgcc tcatacagca
    13321 gtcttccagg atcgtcgatt gagcaagcgc gagacgaggc aacgcgatgg ccgtatcacg
    13381 cggccgtcga gctgcttgtt cagcacgtcg cggcccatag cggttgcgac gtgaactccc
    13441 ggttcgacat tcgaattaag gaggaatcgt ggtctcgaag acgaagaagg tcgtgcgttc
    13501 cgctgccgtg gcgttcgccg cagcagccac gatcaccatg accgtgccgg ccggcgatgc
    13561 tttcgccatc gatcatatcc cctgccgtgg cggggagaac tttctgaaga tctggtcgca
    13621 caacggtgga agtcagagcg tggactgcta cgccaaccgt ggaaggaccg acttcggcgg
    13681 gtggtgggtc gacaagatct ccaccgggaa caacgacttg atctactacg acgccaatgg
    13741 cgattcggtg aaaatcgagc gctggcacga gatcactttc ccgaaccgcc cgcccaaggt
    13801 caactccatc gagatcctgt gacgagttga agggccggct ctccacgggc cgactctcca
    13861 ggaatggcag acgcgccaat ttcgctgatt gtccattctt gggtactgcc gttttccggg
    13921 cgggcatcag gtattccgta gcgttttccg atgtgtgaat ccgctcgcac ccggctcgcc
    13981 aatgccggcc acgcctccgg acgtggccgg cattggctcg gcttggcagc ctcagcagag
    14041 acctcgtcct gcggtaccag cgacgttacg acggccagtc gcgctcagca tcgccgtaca
    14101 taggctcaca cggaggacgg cgacccggcc tcgccgaggc gagggctcga cagtgtcggg
    14161 gcggtcgggg gctcctcgga aggccttcgt acctcaccgt actgctcggt cggcgagccc
    14221 gtcgtacctc gtggacgcgg attggccgac gacccgaaca cgcgtagcct ggaaagtagt
    14281 ggagcacagg gtccgctgct cgggcagcag accaccaagg cgcacaccat ctcaacagtg
    14341 cgcgtggcgc cgggagcccg ccggacctgc atgggctgac tcggctgcct gggcggtttc
    14401 ctcgctcctt tatgagcctt gtgagcctgg ggcagacact ccgcagacgg cttctcgaca
    14461 cgatctcctg tggttctccg gcgcagccgt aaacaactcc tccccggagg agggagaccc
    14521 atggtcgagt acgagaccca ctacgcgagg gccgatgcgg ggcgcgcgcg tgaactcgcc
    14581 gccacaacct ccccgtacac gatcaaagtg cagttcctgg gcgggctgaa ctcgacgcag
    14641 aaggccgcgt tcaccaaggc cgcggaccgc tgggcgaagg tcatcgtcgg agacctgccg
    14701 gatgtgagcg tcgacggcga ggtcatcgac gacctcctga ttctggcgca gggcacatcg
    14761 atcgacgggc ccgggaacat cctgggcgaa gcgggaccga cggtgctgag accggccaac
    14821 ggtcccggtg cgttcctgcc cgcgaagggc acgatgtcat tcgacacgga cgacttggag
    14881 gaaatggcgg ccaacgggac gttggtggat gtgatcaccc atgagatggg gcacgtctgc
    14941 ggcatcggta cccgtccttg gacggagaag aatctgctcc agggcgcggg cggcgacaac
    15001 cccgtcttcc gtggcacgag cgccatggag gagtacggga agctggtggg cgcgggtcag
    15061 cccaggcccg taccggtcga gaaccagggc gggccgggga cacgcgacgg acattggcgt
    15121 gagacggtgt tcgccaacga gctgatgacc ggattcgtgg gcggagcccc caatccgctc
    15181 agccgtctca cggtgggcag cctgaacgac ctcggctacg tcgtggacat ggcggccgcc
    15241 gacgagtacg cgctgcccaa ccacctggag ctggccgaac ggggcgaact gcgcacccac
    15301 gcggcacccg tcggcgccgg cacggtgcag cgcaccatcc cggtcatact gcccgaggac
    15361 agtctgctcg cgtcggcgtg aggatcagcg ctcatgaacg gtgagcgaga gcaccgggcc
    15421 cggggcgggc gcgaagacgc acgcggagca cgcggagagg agaagcgtgc cgtcctgagg
    15481 cccgatacca ccgtcctcag atccgaggcg gtcattccac gggacaacgt cgtgcggccg
    15541 gcgcccaacc ggttcagtca tgtcctggag gagatgcacc cgtactggtt cgagcggtcc
    15601 gagcaggctc cgcagcccga tgggatgctg cccgccggga ccccggtgct cctccttcgg
    15661 gaggagggcg accactgccg tgtggtcacc ggaaccggtc tctacgtcac cgtcgcacgg
    15721 gtgaacctgc ggaagctgcc gggcgacggt gacgggtgac ggcaggtgtg atgccacacc
    15781 gctcaactac gcaccccgta gcacggcggc gcggcgccga ctgccagccg ccagacgacg
    15841 cccgtggcgt cgccggcccg gccgcccggt cagccatggt gcacgtcaac cgtccccggt
    15901 ctcctgctgc cgcgccggat gattcacgcc cgctggtggc cggctggaac gacgggggcc
    15961 gctgcggccg acagggcgca tacggcagta atcgtgacag ccacggggcc cgtcgcggcg
    16021 tgcgcgtccg ctgccgtctc tgcccggtga tcctgagccg gacagcccgc actcgtcgtc
    16081 gccctgggcc ttgccctcgg catcgcgctg gtgatcacgg tcacctcggt gtccgcgggc
    16141 atggccaagg cccaggacaa ggtgctgcag tcgctgtacg gcctgggcac cgacatgacc
    16201 gtgacgaagg cccagccgac cgttccggca ccctgacgaa gagccctggc aaccgtcctt
    16261 gacagtccgg aagcttaggt tggcgcgaga cagggtgcct ggggtcgaac gccgcttgcg
    16321 cgattccgtc agaagggcgc cggatcgggg acccgctgtc acgggctgac cgagcgccag
    16381 acgtagagcc ggcgacgggc gtctgcgacg acgggtccca ggacgagggc ctcgagcgga
    16441 ggcgggcaga tcggcaagcc gaccggcccc tgccgtcacg ccctgtatcg gtagaggatc
    16501 cggccacggg tgaggtcgta ggggctgagt tccacgagca ccctgtcgta cggcaggatc
    16561 ttgatgtagt tcttccggat cttcccgctg atgtgggcga gcaccgtgtg cccgttcttg
    16621 agctccacct tgaaggtggc attgcgcagg cactcggtga cggtgccttc gacttctatg
    16681 ccctttgctg ttttcgtcat ggtctctcaa ctcttccgtt ctgtgacggt gaacgcggtg
    16741 tggtgtggcc gggtgtcagc ggcggacgag ctccagggtg gctgccgcgc gccgggcgcc
    16801 gatgctctcg aacagggcgg tggccgccgc gttggactcg ctcacctcgg cccatgccga
    16861 ggcggttccg gagcggtgca gtgagcccag tgcgtgggcc agcagcgccc gggcgatgcc
    16921 gcggcggtgg ctgtcggtcc ggacggcgat cagcccgatc cgtggttgcc ggggcagggg
    16981 cgccactcgg atcagtccca cgtactggtc gaagtgccgc gccaccgtgt acttcgacgg
    17041 gtcgaccacg gtggtccccg ccgggcgggg cagcacctcg gtcggcatcg tccgccatcc
    17101 ggcggcggcc tcgacctcgt cgcggatgac gcggtccagg gcgcgcagcg ggccctcctc
    17161 cgcctcaccg gcggggacga tcgtcacgcc cgacgggagc cgcggcgagc cgagcccggt
    17221 gacctgcggg tctgtgggca cgagatagcc ccattcgcgg cgtgcggcgg cgaagccggc
    17281 ccgctcccag gcggacctcg agtcgtggtc ggcttcgtcg acgacggtgt acagcggtgt
    17341 ccgcaggtcc gtcagcatcg cgtcggcgat gcggtcgaag accgcgctgt gccacgcgtc
    17401 gatactgatg aagagccgcc cgtcgggtcg gcgcgaagcg tcgccgcggc cgaccacccg
    17461 gtcgtcctcc atggcgtgcc attgcgtgtc cgaaacccgc gtgaccgcga ccgtgtggtc
    17521 gcccgtgccc gaaatggaat gcgtaatgtt cattggtgtt gcctctcggg agtgccttgt
    17581 gtgaggcgct cccggcgaca cctgcgtcaa tcgccgaccg tgacgaaaag ggggagcacc
    17641 catagggata cagccttcat gggtctcgcc tcctcgcgtt ctttcacggc tgcccagacc
    17701 gtaccagcgg ggatccgtcg gcccaaccga tttatcgcag gggccccgcg gacggcctgc
    17761 cgttctcgtg gcccgtaccc gtgggaaatc cggacgatca cgaatactct ggtcgtcgtg
    17821 gggccaaacg acggggtgtg gaagtcggcg ctgtccggct tggagcggtg ggggctcggg
    17881 gcgctgttcg gtgggcgcgg gggcgagcag gggcggtcgt ccggcgggct ggacgatcag
    17941 ggcggggcgc agctgggctg ggggttcacg catacccagt acagcgcgga ccacggtgtt
    18001 ccggacgcca cgcggcgggc cggcgctctg ctctccgggc agcccatgcc gcagaatcag
    18061 catctcatgg gctggggcgc ggagaatccc gaacccgcgc cagggcggta cgacttcgag
    18121 gcgctcgacc agcgcgtcga gctgatgcgg gccaccggcg cggcccccgt cctcaccctg
    18181 tgcggcgctc ccgactggat gaagggcggg cggaaggggc gtaccgactg gtcgcggctg
    18241 gaggcggctc ccgatccccg gcacttcgcc gacttcgcgc ggctggcggg cgtggtcgcg
    18301 cgccggtatc cggacatccg gcacttcctc gtgtggaacg agctgaaggg tttctacgac
    18361 gaggacaagc gccgctggga ctacgagggg tacaccgagc tgtacaacct cgtgcacgcc
    18421 gagctgaagc ggcagaatcc ggagtgtctc gtcggcggcc cctatgtggt ggtcgaccat
    18481 gagccgcccg gtgacgagga cggttcaccg gaggtgcgcg gcgcgtgggg tgcgctcgac
    18541 cggcgctccg tcgatgtcat ccgctactgg aacaagtaca aggtgggggc ggacttcgtc
    18601 gtcgtggacg gggccagtta cacccgtgaa gggcatcgga cgatccccga cgagttcgcc
    18661 gccaccgaga agttcaccga tgtcacgcgc tggctgagga acgtcaccgg gcttccggtg
    18721 tggtgggccg agtggtacgt cgaaccgcct gccgaggacg accgggcggg cggccgggac
    18781 ggctggagcg agcagcaccg cgccgccgtg caggccaccg cgatgacgcg actcgccctg
    18841 ggtggggccg ccaccgctct ctactggaac cctcagcgga tcgagggcga ctgtcctggt
    18901 tgtctgtggc ggagcaccca cttggacgac gggggcgggg ggttgcccat ggcgcggctg
    18961 ctgggctggt tcgcccgcga attcccgccg gggaccgtct tccgccgggt cgccgtctcg
    19021 gccgaggccg gtgcccgcat tcacgtcctc gcccacgaga gtgtcgtgct cgtcgtcagc
    19081 accgagcggc ggcaggtcat ggcgagcgtg gatgggcagg agctgacgtt ggctccgtac
    19141 gaggtgcgct ggctggacgg ttgagtaagc ggagccgggc gggtggttga ctacgtcgca
    19201 tggatttcgc acatgctctc gcgcggcggg aggagctttc agagtccgag cccggccctt
    19261 tgccggtgcc ttcgggcgcg cctcctctcg accccgaact gggcgctgcc ctcgaggctt
    19321 tggggcacgt ggtgagggag ccgatcaccc ctgagaacct cgcggcccgg caggagcggg
    19381 acgccgcggt ccggccgagg ccgacagtcc gggatctccg ggacgacggc cgcttcgagg
    19441 tcgaggagct gcgggtgccg ggagcgtcgg gtgggccgga cgtcacgctc gtgagcgcgc
    19501 ggcccgccgg gatcgacagg gcgcggccgc tgccgctgct gtactacatg cacggcggcg
    19561 gaatgatcag cggtaacgcg tggtccgtgc ttccccggct gcttcgcgaa tgggcttgcg
    19621 ccctggagtt ggttgtcgtc tctgtcgagt accggctggc gccgcaggca cggtatcccg
    19681 gaccggtgga ggattgttac gccggattcg tctgggtggc cgcgcacgcg gccgagctgg
    19741 gcatcgacgc gggccgtatc gtcatcggag ggaagagtgc cggtggtggg ctcgccgcgg
    19801 cgctcgccct gctcgtccgt gaccggggcg ggcccgcgcc gatcgggcaa ctgcttctgt
    19861 gcccgatgct cgacgaccgc aacgacacct tctccagtca ccagatggca ggcgtcgacg
    19921 tctgggaccg gacctccaac gcgaccgcgt ggcaggcgct gctgggtgac cggtacggtg
    19981 ccgccgacct gtcgccctac gcggctcccg ctcgggccac ggatctgtcc gacctacccc
    20041 ctgcctatgt cgaggtcggg tcggccgaga ccttcaggga cgagggtgtg gcctacgcca
    20101 acgcgatctg gcaggccggt ggccaggccg aactgcacgt atggcccgga gcgttccacg
    20161 gcttcgacac cttcgcaccg caggcggctc tcagccagga cgctcgcgat gcccggttcc
    20221 gctggctccg gcgcgttctc acgcagtcca cgcaatccac gccgtccaca cagtccggtg
    20281 cgagcagcgg gcctggcagc gtatgagtgc cggcccatcg ggctcgcgtc agctcaccgc
    20341 ccgcttcacg agcgcgctga tccgcgcctc cacttcggcc gtcacctcgg tcagggcgaa
    20401 cccggccgcc cacatcggcc cgtcgtccag cttcgcctgg tcgctgaaac cgagcgtcgc
    20461 gtagcgtgcc ttgaacttct ccgcgctccg gaagaagcag acgaccttgc cgtgacgcac
    20521 cgggagggcg gcagggcacg ccctgccgcc ctcccggtgg accactactg gccgacggtt
    20581 gccggttcct cggccggttc ggcgcttccc gcaggccccg cggctcccgg cgtgcccgga
    20641 gcggggtgcg tcggcgtggg gcggaccagg gccaggacga ggaggccgcc cacggccgct
    20701 gccgccgccg cgcagaggaa gacgtcctgc atgccgtcgg cgaacacccg gtggatcagt
    20761 tcccgcgcct ccgcctggct gccgtgcggc gcggcggcga cgaggcgctg cgcctggccg
    20821 ccggccaggg cggacgcggc ttcgtgcgcg tccgggacca ggcccgagag ccgcttctgg
    20881 gcggtgtggg tgaacacggc gcccaggacc gcgatggcca aggtcatgcc gagctgccgg
    20941 aaggtgttga ccgcgcccgc cgccatgccc atccgctggg gcggcacgct gccggtggcg
    21001 gcggagacca ggacgggggt ggccaggccg acgcccgcgc cgctcacggc gagcccgatg
    21061 gcgagggagg acgcggtggc gtcggcggac atggcgtcgt acagcaggta catgcccgcg
    21121 gcgatcagga gcaggccgat gccgatcggc agccgtggcg cgagccgctg gatgtggcgg
    21181 ccggcgatcg ccgcgacgag gaaggagacc acggccatgg gggtcagggc caggccgccc
    21241 tcgacggggc cgagcccgag gacggactgc agccacagcg agacgagcac caggcagccg
    21301 aaggcgccgc cctggagcag cagcgcacct cccatgagcc cggcgaagga cgggcggcgc
    21361 agcagcgcga ggtcgagcat gggctggccg ccacggcgtc ccaggcgggt ctccacgagg
    21421 acgaacgcga tgagggaggc cgccgccacg gcgaacgaga tgatcaccgt cggtgaggtc
    21481 cagcccgtct cggcgctccg gatcagcccg taggtcacgg ccgccgcggc gagggtgaag
    21541 gcgacggcgc ccgggatgtc gacacggccg gtccgggcct ggggccgcgc ggtccggtcg
    21601 gcgcgtacga cgcgcagggt cagcaggatg gcgacggcgg cgatgggcag gttgacgagg
    21661 aagatcgcct gccatccgat gtgctcggtg agcagtccgc ccaggatggg gcccgtcgcc
    21721 gcggcggcgc cgttgacggc tccccagatg ccgaacgccg tgccgcggtc gcggccctgg
    21781 tacgtggcgc cgagcagggc cgcggacgtg gcgaacatcg cggcgccgcc cgcgccctgc
    21841 accgcccgcg cggccaccag cacaccggcg ttcggggcga ggccgcaggc cagggaggcc
    21901 agggcgaaga gtgcgagccc ggacacgtag agcttgcggt gcccgaagag gtcggcgatc
    21961 gagccggcgg cgaggagcag cgcggccagc gacagcgcgt aggcgtcgac gacccattgg
    22021 agggaggaga agggggcgtc cagggcctcc gccatctgtg gcagcgccac attgacgatg
    22081 gtgacgtcca ccagaaggat gaaggcgccc agggataccg ccaccagggg ccaccacttg
    22141 cgcatcgatg gaactccgtt cgattcggcc gcgtactggt gcgacgcggt cgtgtccgct
    22201 caggatgggt gcgaggcgcc cgagcgcccc agccagaagg cggtctcgcg cgaaatccga
    22261 cacagcgtaa gctcatgtgg tgaatctcga catcgagcgc ggtgcccttc cggcactcga
    22321 cgcgcaggat cagatgctcg cccacgcgct ccaggtcgac gggcgtgcgt cgttccgccg
    22381 gatcgccgag gtgctcgggg tgtccgacca gaccgtcgcc cgccgctaca cccggctgcg
    22441 gtcggccgga gtcctgcgcg tcctcgggct gaccgatccg ctgcggctcg gcgaggtgcc
    22501 ctggttcgta cggatccgct gcgcgccgag cgccgccgcc cagatcggtg aggcgctggt
    22561 gcggcgcagg gacaccacct gggtccatct cgcgggaggc ggcacggaga tcttctgcct
    22621 cgtgcgggcg cgggggccgc acggggacac gctgctggag aggctcccgg gtacgccccg
    22681 ggtcgtggac gtctccgcgc actgccttct gcacgtcttc ttcggccagg accggagcct
    22741 gatcaccaag acgggaccgt tgacgagcgc gcaggtcacc gccctgaagg cgcaggacgg
    22801 acaggacgcg cccccggaga ccacactcga cggcccggcc ccggcctacc ccctggagga
    22861 agcggactgc cggctgctgg acgcgctggc gcgggatggc cgtgcgagta tcggcgagct
    22921 cgccgtggcg accggctggt cgcagaccac ggtccgccgc cggctggcgg agctgcggtc
    22981 ggccggggtg ctctacttcg acgtcgagta cgcccctcgg gtcatggacc gggacttccg
    23041 cgcctcgctg tggctgagcg tggagccgtc ccacctcgac gcggtgggag aggcgctcgc
    23101 ctc
//
