LOCUS       NZ_CP029617            17355 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 01529 chromosome, complete genome.
ACCESSION   NZ_CP029617
VERSION     NZ_CP029617.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 01529
  ORGANISM  Streptomyces sp. WAC 01529
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. May-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 202.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945545.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:27:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,297
            CDSs (total)                      :: 7,207
            Genes (coding)                    :: 7,110
            CDSs (with protein)               :: 7,110
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 33 of 97
            Pseudo Genes (incomplete)         :: 81 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8010629
            Orig. end                         :: 8027984
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029617.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..17355
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="33"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     cand_cluster    1..17355
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..17355
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:12355]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..12355
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     gene            complement(495..665)
                     /gene="rpmF"
                     /locus_tag="DMA15_RS35240"
                     /old_locus_tag="DMA15_35230"
     CDS             complement(495..665)
                     /GO_component="GO:0000315 - organellar large ribosomal
                     subunit [Evidence IEA]"
                     /GO_component="GO:0022625 - cytosolic large ribosomal
                     subunit [Evidence IEA]"
                     /GO_function="GO:0003735 - structural constituent of
                     ribosome [Evidence IEA]"
                     /GO_process="GO:0006412 - translation [Evidence IEA]"
                     /codon_start=1
                     /gene="rpmF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018487568.1"
                     /locus_tag="DMA15_RS35240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35230"
                     /product="50S ribosomal protein L32"
                     /protein_id="WP_125516740.1"
                     /transl_table=11
                     /translation="MAVPKRKMSRSNTRHRRAQWKASTPQLVPVTVDGERHMVPQRLLK
                     AYERGLLRPES"
     misc_feature    complement(712..726)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 20.17"
                     /tool="antismash"
     misc_feature    complement(713..728)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(734..1987)
                     /locus_tag="DMA15_RS35245"
                     /old_locus_tag="DMA15_35235"
     CDS             complement(734..1987)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014150779.1"
                     /locus_tag="DMA15_RS35245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35235"
                     /product="MFS transporter"
                     /protein_id="WP_125516743.1"
                     /transl_table=11
                     /translation="MAGKRSLGRRFGWLWSAYAVSTFGTRLAFDAFPLIAILVLGSGPT
                     EVAVLAASGLAVGAAVAVPLGPWVEFRRKRPVMIAMDLVRCAALVSVPAAYALGVLGFG
                     QLLVVSVVVAAADITFGAASGAFLKGLVAPRDLLVANGRFESTAWTATMLGPPLGGAAI
                     GLFGPVMTVAADAVSYLLSAVGIGAIRGKEPRPVRADPAARLRARDLLDGWRFILADPV
                     LRPLFFHTVLVNGLIMAAMPLLAVLMLGSLGFAPWQYGLAFALPCLGGLLGSRLAPRLV
                     ARLGQRGVLLASGVLRVCWPLGLALVHSGVSGLVLVMVVEFGVITCSSVYAPVLATYRL
                     EQLPAERVVRTLSAWSVTGKIATAAMTALWGLLAAATGPRAAIATAGLLMLATPLLLPR
                     RESASSTAGAAAGVSEER"
     misc_feature    complement(2017..2030)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.92"
                     /tool="antismash"
     gene            2130..3065
                     /locus_tag="DMA15_RS35250"
                     /old_locus_tag="DMA15_35240"
     CDS             2130..3065
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020397757.1"
                     /locus_tag="DMA15_RS35250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35240"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_125516744.1"
                     /transl_table=11
                     /translation="MDLHAVRAFVAAAEAGQFQGAAADLSITQQAVSKRIATLEKELAV
                     RLFTRTARGARLTIDGQVFLPHARELLQAEERAAASVRPGSRALRVDVIGRRLAPAALL
                     RDFHRARPDAALDVVTLFDADAAISAVRAGTIDAAFRAVTVPARQLPDGIVADRVHDEP
                     LQLLTGPGHALAGARSVTLSQLVGHRIWMPGIVTGTEWAAYYEELAAAFGLTIEATGPD
                     FGTEPLLDTIADAPGLATFVGEQTRLVWPADDDLRRIPVVDPAPVYPHSLIRRDDNPHP
                     TLTALRAHLAAARPTDDATATWTPGWAREG"
     misc_feature    2131..2144
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.74"
                     /tool="antismash"
     gene            complement(3096..3683)
                     /locus_tag="DMA15_RS35255"
                     /old_locus_tag="DMA15_35245"
     CDS             complement(3096..3683)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010359145.1"
                     /locus_tag="DMA15_RS35255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35245"
                     /product="DUF402 domain-containing protein"
                     /protein_id="WP_125516746.1"
                     /transl_table=11
                     /translation="MFGFGDIIRRREMLDGREWIVYPVRVVEDTEDHLAVYLAKGTPLT
                     FGQGDFRWGTHPWANFDHIWQSDGVLQVQRPGDGYSVWHFWKGDTFSGWYINFQEPMRR
                     DARGFDTLDQELDIWVPADGSSFQWKDVEHFEERERLGGFHPGEADAVRTEAQRVVAML
                     DAGTTWWSDRWTDWSAPAIWEVPGRMDLSAPA"
     gene            complement(3711..4940)
                     /locus_tag="DMA15_RS35260"
                     /old_locus_tag="DMA15_35250"
     CDS             complement(3711..4940)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024925.4"
                     /locus_tag="DMA15_RS35260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35250"
                     /product="ATP-grasp domain-containing protein"
                     /protein_id="WP_125516748.1"
                     /sec_met_domain="ATP-grasp (E-value: 2.2e-05, bitscore:
                     22.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 6.5e-06, bitscore:
                     25.0, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPEAVILLFSGTKPRHAPLLDSAVRAVHDAGLAAVCVAPSKVAL
                     SGGEPDAWGVYRPGAGHEDRVIEAAHEASGPFRAVRVISLFEDDVRAAATLREQLGVEG
                     LTVEQSIYFRDKNAMNVRAAELGLRTAIWTLPHTKNHVRQFAAEHQYPIVIKPYDGVSC
                     TNTYKVTSDEELDRTWPLLQAQRHDYRVEAFIHGKQFHVDTMVRDGEVLFESVGEYTAQ
                     ILENWQDAPMGSVTHPATGVHREMLDAARTVVTSFGLRTGIAHTEFYLDDEGTLTFGET
                     AARMAGAWVPSMYRHAYGIDLAYDSVRAEVEPGYTPAGDISGCTGASYLWSSATGRIDR
                     ITDADSLSALPYVCHVEVNKAPGDVLPPVVGTRGQDLGHVVVAGKSPAEVSENLRDIHT
                     RFSVLTTNVP"
     gene            complement(5001..6119)
                     /locus_tag="DMA15_RS35265"
                     /old_locus_tag="DMA15_35255"
     CDS             complement(5001..6119)
                     /EC_number="1.1.1.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358790.1"
                     /locus_tag="DMA15_RS35265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35255"
                     /product="iron-containing alcohol dehydrogenase"
                     /protein_id="WP_125516751.1"
                     /sec_met_domain="Fe-ADH (E-value: 1.1e-82, bitscore: 276.5,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHFDFHIPTRIRFGRGRLDELGSVVAEFADSALLMTGRHAMKAAG
                     FQERALASLRAAGVRGVVFDQISANPRSDEVDRALELARGLKVGAVVGMGGGSVLDSAK
                     ATAAAIHLGPVGPLVGTTLAADTPTLPMIAVPTTAGSGAEVTKGAILTDTARGFKSGIR
                     GDAIFPRAALVDPALTDGLPRHVALESGFDALAHAIEGAVARRSTALNKNLSRQAVDLL
                     SVHLREVADGRADAESRDALSLAALLGGINVATASTCLPHRLQQAMGRGARNEPSHGLG
                     LAILYPAWLRAAYPYAPTAFDDLAAVLGDESIHQGVGRLLKDTGLDITLTAAGYAADDI
                     AGFLANLSGNVDNDPITDIPRELIAEIYRNSL"
     gene            complement(6109..7326)
                     /gene="pgk"
                     /locus_tag="DMA15_RS35270"
                     /old_locus_tag="DMA15_35260"
     CDS             complement(6109..7326)
                     /GO_function="GO:0004618 - phosphoglycerate kinase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pgk"
                     /inference="COORDINATES: protein motif:HMM:NF012389.4"
                     /locus_tag="DMA15_RS35270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35260"
                     /product="phosphoglycerate kinase"
                     /protein_id="WP_125516753.1"
                     /transl_table=11
                     /translation="MSASTTLHSVGLLREQPIHPGQRWVYSAGFNVVSGMTDTSRIDCE
                     LDDLRYLADRGARVAILSHQGSHRDGTAVHLAGTAEYLGKRLGRPVTYIPESASDDAVT
                     AARSLADGQVALFGNTRLHSGEEDNDPVLAAQFARLGDYAAIGGFSKAHRRHASNVGIL
                     RHLPGWAAGSLIDETRRLEPWAGRSPKTPSIAAVGGVKSEKSVVGLPCFARDYDIVVPG
                     GIVLNHVLHHLGYAIGSSPLGNDVERRAAATKAALANPRARIHVPRRVVIARADRHGWH
                     EAHTVSVSEGVPTGFSIVDFHLHPWLIQELRRVAACGGRLIIAGTPNLHTHGFTQASSA
                     LLDAARTPTVSAMLLGGDTVAELPFDGVTSTGGGSALCYLDQADVVVLDALRRNNGLTM
                     RSRRAL"
     gene            complement(7329..8429)
                     /gene="argC"
                     /locus_tag="DMA15_RS35275"
                     /old_locus_tag="DMA15_35265"
     CDS             complement(7329..8429)
                     /EC_number="1.2.1.38"
                     /GO_function="GO:0003942 -
                     N-acetyl-gamma-glutamyl-phosphate reductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006592 - ornithine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="argC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1219: N-acetyl-gamma-glutamyl-phosphate reductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358785.1"
                     /locus_tag="DMA15_RS35275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35265"
                     /product="N-acetyl-gamma-glutamyl-phosphate reductase"
                     /protein_id="WP_125516755.1"
                     /transl_table=11
                     /translation="MNHQTLNVAVVGGTGYSGGELCRLLLNHPRVGSIWPTARGDEEFE
                     RIHANLRGSGLRFVTLEDVQARVDELDVVFFCTPSGQAMRQAGWFLERDVKVVDVSADF
                     RFADPATYQRVYGTAHAVPELLAEAAYGVTELNREAIAKSRLVANPGCYVITAILGLTP
                     LLRAGWADLSSPLHLSAVNGTTGAGNKPKRPIMHAEALNSMLPYSMEGHRHGPELETHL
                     AVAAGRDLVVDFNTAHGNFARGIHLQANLAVNPDLAATMSRERLLGCLTEFYGAGAEGE
                     FFVRVNDLAKSGGLNAKDYDVYPGVASVTGSNFCHIGADYDERRGIIKILSVTDNLVKG
                     AAGSAIQNMNVMLGLEETLALRTYGL"
     gene            complement(8524..9501)
                     /locus_tag="DMA15_RS35280"
                     /old_locus_tag="DMA15_35270"
     CDS             complement(8524..9501)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072: dehydrogenase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010358783.1"
                     /locus_tag="DMA15_RS35280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35270"
                     /product="hydroxyacid dehydrogenase"
                     /protein_id="WP_125516757.1"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.7e-58, bitscore:
                     194.5, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFKPPTVQRHTLPRVLVVDPLASDALEALRRIYDVTVQMQPAED
                     ELAVLLRQTDAIVLRSGVKLPGHLIADAPDLKVIARAGNGTDNIDLAAARSAGVQVFNI
                     PGVSSPAVAELALGLAFSVARHIAAADQQVRANVWRKADLVGSELSGKTMGVVGLGSIG
                     SRVAELARGIGMSVIASARRRDDERREACRRSGIDLRSTEEVLAEADVVVLACPLNDHT
                     RGLIDADALRLMKPTAFLVNVARGGVVDEDALRVALLEGVIAGAALDVHAAERAPSGLA
                     GLDNVVLTPHIGAMTRDSQERIGQLLLEGLRLALSGRDAPTRVC"
     misc_feature    complement(9469..9479)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    9492..9506
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 21.13"
                     /tool="antismash"
     misc_feature    9503..9518
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.57"
                     /tool="antismash"
     misc_feature    complement(9521..9535)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.83"
                     /tool="antismash"
     misc_feature    9777..9792
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.02"
                     /tool="antismash"
     gene            10163..11431
                     /locus_tag="DMA15_RS35285"
                     /old_locus_tag="DMA15_35275"
     CDS             10163..11431
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="DMA15_RS35285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35275"
                     /product="MFS transporter"
                     /protein_id="WP_125516759.1"
                     /transl_table=11
                     /translation="MQQRHAKRLIRQLRGLLPDAGAARRLCLLTAVQSAGSGVFLSSSV
                     IFFSRYAGLSPTQVGLGLAVAGGVGFLATVPAGRLADRFRPRSLLALGYSALVPLFISY
                     GFVRTFPAFIAAASLISVCETTGSPLRATLMHQLFREEGAVRVRAQMRSFFNVGYMLGA
                     AVASIALTVGTSRAFYAVLLLNALAQACCVYIVLSVRVPAAAPRAAPPRKGMRGALSNV
                     PFLALTAVNGILELHYTIFTVGVPLWIVTHAHVPAGLNSVVIALDTVLVILLQVPLSRG
                     TGTLAEGANQMRRGAWFMAIACAVYALSQSSSEVVAICFLLVGTVILVFGEIFQSAGSW
                     TISFKLPPAGKQGEYQGVYALGRGVREFAGPALLTALIVPLAWCGWIVLMAIFLALSTL
                     VGPLAEMAERHASRAVVEPTPSR"
     gene            11492..12355
                     /locus_tag="DMA15_RS35290"
                     /old_locus_tag="DMA15_35280"
     CDS             11492..12355
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231: carboxyvinyl-carboxyphosphonate"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019075322.1"
                     /locus_tag="DMA15_RS35290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35280"
                     /product="isocitrate lyase/phosphoenolpyruvate mutase
                     family protein"
                     /protein_id="WP_125516761.1"
                     /sec_met_domain="phosphonates-like (E-value: 3.9e-114,
                     bitscore: 379.0, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.8e-101, bitscore:
                     335.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2e-64, bitscore:
                     216.1, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRPQSPSFRSVVAKGEIVRVAGAHDALGGILAEQAGFDAVWSSS
                     LEVSAARCLPDASVLTMTEYLEAAANMQKALGIPVIADCDTGYGNNLNVVHMVHEYEAA
                     GITAVCMEDKLFPKLNSFAGGDQTLLSTEEFCGKIRAAKKAQRTDEFFVVARTEALING
                     LSVDVALERAYAYAEAGADAVLIHSKSKEKDEVEEFLNRWDGCRPVVIVPTTYPNWHID
                     DIAKAGASVVIYANQGLRATVSSLRKTFESIRRHGDTTALEESIAPVKEVFGLQKLKDW
                     QALETV"
     gene            12653..12883
                     /locus_tag="DMA15_RS35295"
                     /old_locus_tag="DMA15_35285"
     CDS             12653..12883
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004979480.1"
                     /locus_tag="DMA15_RS35295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35285"
                     /product="hypothetical protein"
                     /protein_id="WP_125516763.1"
                     /transl_table=11
                     /translation="MSEYPYVTHPRITVLGVQPGSPPFRIVEIDGEVVGTAKTVTDVLD
                     AAVMAGITVHDLDDPDAVRWVGGDKFTWRPR"
     gene            complement(12944..14050)
                     /locus_tag="DMA15_RS35300"
                     /old_locus_tag="DMA15_35290"
     CDS             complement(12944..14050)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018090418.1"
                     /locus_tag="DMA15_RS35300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35290"
                     /product="glutathione S-transferase C-terminal
                     domain-containing protein"
                     /protein_id="WP_125516765.1"
                     /transl_table=11
                     /translation="MSAAESEPAAGGSAEGGSAEGGSAEGGSAEGGSAEGNASYGHKEF
                     KRSKSHFADRVTADGRDGWPVEAGRYRLVVSRACPWAGRSLVSRRLLGLEDALSLGVTD
                     PIQDDRSWRFTLDPGGRDPVLGIRFLSEAYEARESGFPGGVSVPALVDVPSGKLVTNDF
                     QQITLDFATQWTALHREGAPDLYPQPLRDEIDSVMEGIFRDVNNGVYRAGFAPDQGAYD
                     AACRDVFRRLELTSERLASRRYLVGETITEADIRLFSTLVRFDAVYHGHFKCNRRKLTE
                     DPVLWAYARDLFQTPGFGDTIDFDHIKRHYYQVHSGINPTGIVPLGPDLDGWLTPHHRE
                     ELGGRPFGDGTPPGPVPAGEEVPAPGRP"
     gene            complement(14047..14340)
                     /locus_tag="DMA15_RS35305"
                     /old_locus_tag="DMA15_35295"
     CDS             complement(14047..14340)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015031627.1"
                     /locus_tag="DMA15_RS35305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35295"
                     /product="hypothetical protein"
                     /protein_id="WP_240660108.1"
                     /transl_table=11
                     /translation="MTGTTSEELLAAQACLRLLHTARAALSDGSEVPPAAAASLLAGPI
                     AEADDALRRAGLAGNEAVLIERIYDLTPPPRSAEQAAPSGVARSCAREGSQS"
     gene            complement(14428..15909)
                     /locus_tag="DMA15_RS35310"
                     /old_locus_tag="DMA15_35300"
     CDS             complement(14428..15909)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020127645.1"
                     /locus_tag="DMA15_RS35310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35300"
                     /product="cytochrome P450"
                     /protein_id="WP_125516767.1"
                     /sec_met_domain="p450 (E-value: 4.7e-79, bitscore: 265.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQTTRSAAGPTEPVGPPPKGFRSAELGWPELHRIPHPPRRLPFL
                     GDVLGADVRTPLQDSMRMGRRLGPIFRRKAFGKEFVFVWGAALAADLADETRFAKHVGL
                     GVANLRPVAGDGLFTAYNHEPNWQLAHDILAPGFSREAMAGYHPLMLDVARRLTARWDE
                     WEAAGRAVDVPGDMTKLTLETIARTGFGHDFGSFERSAPHPFVRAMVGTLSFAQRRNVV
                     PPLLTPVLLRGAVRRNDADMAYLNRTVDAVVAARRAASSSGGQGDLLDRMLEVAHPETG
                     ERLSPENIRRQVITFLVAGHETTSGALSFALHYLSRSPEVLSRARAEVDEVWGAEGEPA
                     YEQVAKVRYLRRVLDESLRLWPTAPAFAREARQDTVLGGVHPMRRGAWALVLATMLHRD
                     PAAWGERPDEFDPDRFAPSAVRARPAHVFKPFGTGARACIGRQFALHEATLVLGLLLRR
                     YDLHADPGYRLRVAERLTLMPDGLTLRLTRRSPAA"
     gene            16019..16627
                     /locus_tag="DMA15_RS35315"
                     /old_locus_tag="DMA15_35305"
     CDS             16019..16627
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010040678.1"
                     /locus_tag="DMA15_RS35315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35305"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_125516769.1"
                     /transl_table=11
                     /translation="MAANPPERTRRRMSTEERREQLLSVGARLFAQKPYDDVWIERVAE
                     IAGVSRGLLYHYFPAKRDFFAAVVQRESERMLRLTAAVPGLPVREQISAGLDAFLGYVE
                     SHAQGFRAFHRAEAAGDPLVREVYGRGLAAQERQILAALAADPDAADLIRDPPALRLAV
                     RGWLAFMVAVCLEWLAEPELTRAQVRDLCARALLGAITR"
     gene            complement(16665..17303)
                     /locus_tag="DMA15_RS35320"
                     /old_locus_tag="DMA15_35310"
     CDS             complement(16665..17303)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018563814.1"
                     /locus_tag="DMA15_RS35320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_35310"
                     /product="HAD family phosphatase"
                     /protein_id="WP_240660109.1"
                     /sec_met_domain="HAD_2 (E-value: 8.4e-09, bitscore: 34.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDLMNDPVNGPAHDILLFDMFGVIARHQSEDGKARLTALADVPE
                     SRFWEAYWGLRQPYDRGDIAGFDYWRGVADALGTDFGPHRIARLIEADIASWSSVDDTM
                     VALVEELAAAGRPIALLSNIPEELAVHYEGRHPWLKHFQVRGFSCRIGHAKPEPGAYRW
                     CLDALGAEPERVLFVDDREDNIRAAGASGIRGHLFTTPARLREALRLSA"
ORIGIN
        1 accgcgctcc acgaggccgt caccgccggt gagttccggc aggaagttgg cggcgtccac
       61 caccgtcacc atcgtgtcga gccgggccag atcgccgagc gtggcgccgt cgtcgcgcgg
      121 gaacgcgaag gtcgcggcca ccggcatcgg ctcggagatg ccgctcgact cgatgagcag
      181 atggtcgaag cggccctcgc gggccagccg gtcgacctct tcgagcaggt cgtcgcggag
      241 ggtgcagcag atgcagccgt tggtcagctc gaccaggcgt tcctcggtgc gggagagggc
      301 ggcctcgccg ccgcgcacca gagcggcgtc gatgttgacc tcgctcatgt cgttgacgat
      361 caccgcgacg cgcaggccgt cgcggttgcc taggacgtgg ttgagcagcg tggtcttgcc
      421 cgcgccgaga aagccggaga ggacggtcac gggcagccgc gcggtcggta cgtgcgtcat
      481 gtgcgggacg gctctcagct ctcggggcgc agcaggccgc gctcgtacgc cttgagcagc
      541 cgctgcggga ccatgtgccg ctcgccgtcg acggtgacgg gcaccagctg cggggtgctg
      601 gccttccact gggcgcggcg gtggcgggtg ttgctgcggg acatcttccg cttgggtacg
      661 gccatggggt cctcctgaga tgagggggtg agcgacgcct gcgacgctat atgaaaatgg
      721 atcccattaa caactagcgc tcttcgctga ccccggccgc ggcgcccgcc gtgctggacg
      781 cggactcccg ccgcggcagc agcagcggag tggccagcat gagcagcccg gcggtcgcga
      841 tcgcggcgcg agggcccgtg gcggcggcca gcagccccca cagggccgtc atggccgccg
      901 tggcgatctt gccggtgacc gaccacgcgg acagggtgcg gaccacgcgc tccgccggaa
      961 gctgttcgag gcggtaggtg gcgagcaccg gcgcgtacac gctcgagcag gtgatcacgc
     1021 cgaactcgac gaccatcacg aggacgagtc cgctgacgcc ggagtggacg agggcgaggc
     1081 cgaggggcca gcacacgcgc agcacccccg aggcgagcag gaccccgcgc tgcccgagcc
     1141 gtgccacgag gcgcggggcc agccgcgagc cgagcagacc gccgaggcag gggagggcga
     1201 aggccaggcc gtactgccag ggcgcgaagc cgaggctgcc gagcatcagg acggcgagca
     1261 gcggcatcgc cgccatgatc aggccgttga ccagcaccgt gtggaagaac agcggacgca
     1321 gcaccggatc ggcgaggatg aagcgccacc cgtccagcag gtcccttgcc cgcagccggg
     1381 ccgccgggtc ggcgcggaca gggcggggct ccttcccgcg gatcgccccg atgcccacgg
     1441 ccgagagcag gtagctgacc gcgtcggcgg ccacggtcat cacggggccg aagaggccga
     1501 tcgccgcccc gccgaggggc ggcccgagca tggtcgccgt ccaggccgtc gactcgaacc
     1561 gcccgttcgc gacgagcagg tcccgtggcg ccaccagccc cttgaggaag gcaccggaag
     1621 ccgcgccgaa ggtgatgtcg gccgcggcga ccacgaccga gacgacgagc agctgcccga
     1681 agccgagcac cccgagcgcg tacgcggcgg gaacgctcac aagcgccgcg caccgcacca
     1741 gatccatcgc gatcatcacc ggccgcttgc ggcggaactc cacccacggc ccgagcggca
     1801 cggccaccgc cgcccccacc gcgagccccg acgcggcgag gaccgccacc tccgtgggcc
     1861 cggagcccag caccaggatc gcgatcaggg gaaacgcgtc gaacgccagc cgcgtaccga
     1921 acgtactgac cgcgtacgcc gaccacagcc acccgaaccg ccgcccgagc gaccgcttcc
     1981 ccgccactgc ccaaccccac ttcgaacaac cccgcgttga cctgcgtcat ccaaccgaat
     2041 gacccgtcgc ccgagcaaac aaccgactcg cgtggtcggc cacaaccgcg cgttgtgttc
     2101 ccgggtgcgt gctccctagg gtggccgtca tggatctcca tgcagtgcgc gccttcgtcg
     2161 ccgccgcgga ggcgggccag ttccagggag ccgccgccga cctgtcgatc acccagcagg
     2221 ccgtctccaa gcgcatcgcc acgctggaga aggagctggc ggtacggctg ttcacccgca
     2281 ccgcccgcgg cgcacggctc accatcgacg gacaggtgtt cctgccgcac gcccgcgaac
     2341 tcctccaggc cgaggagcgc gccgccgcct ccgtacggcc cggcagccgc gcgctgcgcg
     2401 tcgacgtgat cggccgccgc ctcgcaccgg ccgccctgct gcgcgacttc caccgcgccc
     2461 gtcccgacgc cgcgctggac gtggtgacgc tcttcgacgc cgacgcggcc atctccgccg
     2521 tcagggccgg cacgatcgac gcggcgttcc gcgccgtcac cgtgcccgcc cggcagctcc
     2581 ccgacggcat cgtggccgac cgggtccacg acgagcccct ccagctcctc accgggccgg
     2641 gccacgcgct cgccggggcc cgctcggtca ccctgtccca gctcgtcggg caccggatct
     2701 ggatgcccgg catcgtcacc ggaaccgagt gggccgccta ctacgaggaa ctcgccgcgg
     2761 ccttcgggct caccatcgag gcgacgggac ccgacttcgg caccgaaccg ctcctggaca
     2821 ccatcgccga cgccccgggg ctcgccacct tcgtcggcga gcagacccgc ctggtctggc
     2881 ccgccgacga cgacctgcgg cgcatcccgg tggtcgaccc ggcaccggtc tacccgcact
     2941 ccctgatccg ccgcgacgac aacccgcacc ccacgctcac cgcactccgc gcccacctcg
     3001 ccgccgcccg ccccaccgat gacgccaccg cgacctggac accgggctgg gcccgggaag
     3061 ggtgagcggc ccctccgggt gaccgcgggc aatgatcaag caggggcgga aaggtccatg
     3121 cgtcccggca cttcccagat cgcgggagcg gaccagtccg tccacctgtc gctccaccac
     3181 gtggtgcccg cgtccagcat ggccaccact cgctgggcct cggtgcgcac ggcgtcggcc
     3241 tcgcccgggt ggaagcctcc caggcgctcc cgctcctcga aatgctccac atccttccac
     3301 tggaaggaac tgccgtctgc gggcacccag atgtccagtt cctgatcgag ggtgtcgaac
     3361 cccctcgcgt ccctccgcat gggctcctgg aaattgatgt accaccccga aaatgtgtca
     3421 cctttccaga agtgccatac ggagtagccg tcgcccggcc gctgcacttg gagcacaccg
     3481 tcggactgcc agatgtgatc gaagttcgcc cagggatggg tgccccatcg gaaatccccc
     3541 tgcccgaacg tgagtggcgt ccccttcgcc aagtacacgg cgagatggtc ttcggtgtcc
     3601 tcgaccacgc gcaccgggta gacgatccat tcacggccgt cgagcatttc gcgccgccgg
     3661 atgatgtcac cgaagccgaa catgtgcacc actctctccg tttgtcgatc tcaaggaacg
     3721 tttgtggtga gaactgagaa tcgggtgtgg atgtcccgaa ggttctcgct cacttctgcc
     3781 ggtgactttc ccgccacgac tacgtggccg aggtcctggc ctcgcgtacc gacgactggg
     3841 ggcaagacgt cgccgggagc cttgttcacc tcgacgtggc agacgtaggg cagggctgac
     3901 agggagtcgg cgtcagtgat gcggtcgatc ctgccggtgg cggaactcca gaggtacgag
     3961 gcgcctgtgc agccggagat gtcgccggcc ggggtgtagc cgggctcgac ctcggcgcgt
     4021 acggagtcat acgcgagatc gattccgtag gcatgccggt acatcgacgg cacccatgca
     4081 ccggccatac gtgcggctgt ctcgccgaac gtcagcgttc cctcgtcgtc gaggtagaac
     4141 tccgtgtgcg ctatccctgt gcgcagtccg aaggaggtga ctaccgtccg tgccgcgtcg
     4201 agcatctccc ggtgaacccc tgtggccggg tgcgtgacgc ttcccatcgg ggcgtcctgc
     4261 cagttctcca gtatctgtgc cgtgtactcc ccgaccgatt cgaagagaac ttcgccgtct
     4321 cgcaccatgg tgtccacgtg gaactgcttg ccatgaatga aggcttcgac gcggtagtca
     4381 tggcgctgcg cctgcaggag aggccaggtg cggtcgagtt cttcgtccga cgtcaccttg
     4441 taggtgtttg tgcaggacac tccgtcatac ggctttatca cgatggggta ttgatgttcc
     4501 gccgcgaact gccgtacatg gttcttggtg tgggggagcg tccagatggc ggtccgcagg
     4561 cccagttccg ccgcgcggac gttcatcgcg ttcttgtcgc ggaagtagat gctctgttcg
     4621 acggtcagcc cctcgacgcc gagctgttcg cgcagtgtcg ccgcggccct gacgtcgtcc
     4681 tcgaagagcg agatcacccg gactgcgcga aaaggtccgg atgcctcgtg tgcggcctct
     4741 atgactcgat cctcatggcc cgcgcccggc cggtagacgc cccatgcgtc gggttcgcca
     4801 cctgagagtg ccaccttcga gggggcgacg cagacggcgg ccagaccggc gtcgtgcacg
     4861 gcgcgcaccg cgctgtcgag caacggcgca tgacgtggct tggtgccgga gaagaggaga
     4921 atgacggcct ctggcttcat ggttgccctt cggctgagtt tgatcgaaag ggaatcgaaa
     4981 gggagtaggc gggcggagcc tcacagggag ttgcggtaga tctcggcgat cagttccctg
     5041 ggtatgtccg tgatgggatc gttgtcgaca tttccgctca ggttcgcgag gaagcccgcg
     5101 atgtcgtccg ccgcgtatcc ggcggccgtc agggtgatgt cgagtccggt gtccttcagg
     5161 aggcgtccga cgccctggtg gatgctctcg tctcccagga ccgcggccag gtcgtcgaag
     5221 gcggtcggag cgtaggggta ggcggcgcgg agccaggcgg ggtagaggat ggcgagaccc
     5281 agaccgtgtg agggttcgtt gcgggcaccg cggcccatcg cctgctgcaa gcggtgggga
     5341 aggcaggtgc tcgccgtggc cacgttgatt ccacccagca acgcggccag gctcaaggcg
     5401 tcccgggact cggcgtcggc acgtccgtcg gcgacctcgc gcagatgcac ggagagcagg
     5461 tcgacagcct ggcgggagag gttcttgttg agggctgtgg agcgtcgggc gactgcgccc
     5521 tctatcgcgt gggccagtgc gtcgaagccc gactcgaggg ccacatggcg gggaagccca
     5581 tcggtgagag cgggatccac gagcgcggca cgggggaaga tggcgtcacc gcggatgccg
     5641 gacttgaacc cgcgcgcggt gtcggtgagg atcgcgcctt tggtgacctc cgcgccgctc
     5701 ccggcggtgg tgggcaccgc gatcatcggc agtgtggggg tgtcggctgc cagagtggtg
     5761 ccgaccagcg ggccgaccgg accgaggtgg atggctgcgg ccgtcgcctt ggcggagtcg
     5821 agcacactcc ctccgcccat gccgacgacg gcgccgacct tgagaccgcg cgccagctcc
     5881 agcgcgcgat ccacctcgtc cgaccggggg ttcgccgaga tctggtcgaa gacgacgccc
     5941 cgtacgccgg cggcccggag actggcaagc gcacgttcct gaaatccggc agccttcatt
     6001 gcgtgccgtc cggtcatcag caaggcgctg tcagcgaact cggcgacgac cgaacccagt
     6061 tcgtccaggc ggccgcgacc gaaacggatg cgggtgggaa tgtggaagtc aaagtgcacg
     6121 acggctcctc atggtcagcc cgttgttgcg cctgagcgcg tcgaggacga caacgtccgc
     6181 ctggtcgagg tagcacagag ccgagccgcc cccggtcgac gtgacgccgt cgaacggcag
     6241 ctcagctacg gtgtcaccgc ccaacaacat ggcgctgacc gtgggtgtgc gcgcggcgtc
     6301 caggagcgcg gaggacgctt gggtgaaccc gtgggtatgg aggttggggg tgcccgcgat
     6361 gatgagccgg cccccgcacg cggccactct cctcagttcc tggatgagcc aggggtggag
     6421 gtggaagtcg acgatggaga agccggtcgg caccccctcg ctgacggaaa cggtgtgggc
     6481 ttcgtgccat ccgtggcggt cggcccgggc gatcacgacg cgtcgtggga catggatacg
     6541 ggctcgggga ttcgccaggg cggccttggt ggccgcggcc cggcgctcga catcgttgcc
     6601 caggggtgag ctgccgatgg cgtatcccag gtggtgcagc acatggttga ggacgatgcc
     6661 gccggggacg acgatgtcgt aatcgcgggc gaagcatgga aggccgacga cgctcttctc
     6721 gctcttcacc ccgccgaccg ccgcgatcga cggcgtcttg ggggacctcc ccgcccaggg
     6781 ttcgagtctg cgggtctcat cgatgagact gccagcggcc cagccgggca gatgacggag
     6841 gattcccacg ttcgaggcgt ggcgtcggtg ggccttggag aatccgccga tcgccgcgta
     6901 gtcgccgagc cttgcgaact gggccgccag gacaggatcg ttgtcttctt ccccgctgtg
     6961 caggcgggtg tttccgaaga gggcgacctg cccgtcggcg agtgagcgtg cagcggtgac
     7021 cgcgtcgtcc gaggcgctct cggggatgta ggtgaccggg cggccgagcc gcttgcccag
     7081 gtactcggcg gtccctgcca gatgcacggc cgtgccgtcg cggtgacttc cctggtggga
     7141 gaggatggcc acgcgcgcgc ctcggtcggc gaggtagcgc aggtcgtcga gttcgcagtc
     7201 gatgcgggac gtgtcggtca tgccggagac gacgttgaag ccggccgagt acacccagcg
     7261 ctgtccgggg tgaatgggct gctctcgcag gaggccgacg gagtggaggg tcgtgctcgc
     7321 tgacatggtc acagtccgta cgtccgaaga gccagcgtct cctcaagacc gagcatgacg
     7381 ttcatgttct ggatggccga tcccgccgct cccttcacca ggttgtcggt gacggaaagg
     7441 atcttgataa tgccgcgccg ctcgtcgtaa tcggcgccga tgtggcagaa gttggagccc
     7501 gtgaccgagg ccacgcccgg gtagacgtcg tagtccttgg cgttgagacc accgctcttg
     7561 gcgaggtcgt tgacgcgaac gaagaactcc ccttccgcac cggcgccgta gaactccgtc
     7621 aggcatccca ggagcctctc gcgcgacatg gtcgccgcca ggtcgggatt gaccgccaga
     7681 ttcgcctgga ggtggatgcc acgggcgaag ttgccgtggg cggtgttgaa gtcgacgacc
     7741 agatcacgcc cggccgccac agcgaggtgg gtttccagtt cggggccgtg gcggtggccc
     7801 tccatgctgt agggaagcat ggagttgagg gcctcggcgt gcatgatggg ccgcttgggc
     7861 ttgtttccgg cgccggtggt tccgttgacg gcactgaggt gaagggggct gctcaaatcc
     7921 gcccatccgg ctcgcagaag aggagtgagt cccaagatgg cggtgatgac atagcagccc
     7981 gggttggcca cgagcctgct tttcgcgatg gcttcacggt tgagttcggt cacgccgtag
     8041 gccgcttcgg ccagcagttc gggcacggcg tgagcggtgc cgtatacgcg ctgatacgtc
     8101 gcgggatcgg cgaaacggaa gtcggcactg acgtcgacaa ccttgacatc gcgttcgagg
     8161 aaccagccgg cctggcgcat ggcctgcccg gaaggagtgc agaagaagac cacgtcgagt
     8221 tcgtccacgc gcgcctggac atcctcaagg gtgacgaagc gcaggccgct gccgcgcagg
     8281 ttcgcatgaa tccgctcgaa ctcctcgtct ccccgggcgg tgggccagat cgatccgaca
     8341 cgagggtggt tgagcaggag gcggcagagc tccccgccgg agtagccggt tccgccaacg
     8401 acggcgacgt tgagcgtctg gtggttcacg tacgtagtcc tcgacaaatg gttgcgaaaa
     8461 gagagaagag agagaagaga gaagagaaga gagaaggggg atcggcctgg ggatcgacgg
     8521 cgatcagcag actcgggtgg gggcgtcccg cccggacagc gccaaccgga ggccttcgag
     8581 cagcagttgg ccgatgcgtt cctgggagtc ccgggtcatc gcgccgatat gcggggtgag
     8641 gacgacgttg tcgagccctg ccaggccact gggagcacgc tccgccgcgt gtacgtcaag
     8701 ggcagcgccg gcgatgaccc cttcaagcag ggcgacgcga agggcatcct cgtcgacgac
     8761 accgccacgg gccacgttca ccaagaaggc ggtgggcttc atcagtcgca gcgcgtcggc
     8821 gtcgatgagg ccgcgggtgt ggtcattgag cgggcacgcg aggaccacga cgtccgcttc
     8881 ggccaggacc tcctcggtcg accgcaggtc gatccctgac cggcggcacg cctcgcgccg
     8941 ctcgtcatcg cgccgccgcg ccgacgcgat gacggacatg ccgattcccc gggcgagttc
     9001 ggcgaccctg gagccgatgc ttcccagccc gaccacaccc atggtcttgc cggacagctc
     9061 gctgccgacc agatcggcct tgcgccatac gttcgcgcgg acctgctggt cggccgccgc
     9121 gatgtgacga gccaccgaga aggcgagccc cagagccagt tcggcgaccg ccggcgagga
     9181 aacgccggga atgttgaaga cctgcacccc cgccgaccgt gcggccgcca ggtcgatgtt
     9241 gtccgtccca ttgccggcac gcgcgatcac cttcaggtca ggtgcgtcgg cgatcagatg
     9301 gcccggcagt ttcacgccac tgcgcagcac gatggcatcg gtctggcgca gcagtacggc
     9361 cagttcatcc tcggcaggct gcatctggac ggtcacgtcg tagatgcgcc gcagcgcttc
     9421 gagggcgtcg gaagcgaggg gatcgacaac gagaacacgt gggagtgtgt gacgttgcac
     9481 cgtcggaggc ttgaaagtca tgtcctgatt cttttcacgg tggccgaaga gaacgacctt
     9541 cgaacggtga cctggcgctc gcacccgctg cggcaggccc cgtctcgcga ctcggaagac
     9601 acggatcgtt cctccgcgcc tgggcggcag gcggagatcc gatccggggc aggcctcacg
     9661 cccggcgccg tccggcgcac cttgcgctcg tcggccagtg gcgttcagca gacgctgtgc
     9721 cgtcgctcgc cgggggacct gccggacaca aagcaagcac cccaccgaaa gggctgtcaa
     9781 cgatttgttg ccttcgccac atacgcatgc gaagcgaagc aactcgccct gaataaaagg
     9841 gagttggtca ctggcttgcg cttaatcacc catgctttta cttgatcatt gctgacggcc
     9901 aagttgatct tgacttgccg tgaggcgccg ctcacatccc aagtagggac cggtggcgaa
     9961 aaagggacat cttgcagccc cccgcgcagg ttcacccgtc gtcggcttgc cgttcattca
    10021 cttgacatct ttcgggtgac gggcgaatgt cctgaatgcc aacgaccaca agtcaacaga
    10081 ttccatcgcc acttgagcgc tcaccgcatg cgcgcacccc gcggccccgg ctgcctcaac
    10141 gcgatgacgg gttcggttct tcatgcaaca aagacatgcc aagaggctca tacggcaatt
    10201 gcgagggctc ctgcccgacg ctggtgccgc gcgcagactc tgtctcctga cagccgtcca
    10261 gtcggcgggt agcggagtat tcctgtcgtc gagcgtgatt ttcttcagtc ggtacgcggg
    10321 gctgtcaccc acacaagtgg gcctcggtct ggcggtggcg ggcggagtcg gattcctggc
    10381 cacggttccg gcgggccggt tggccgatcg cttcaggccg cgaagcctcc tggctctcgg
    10441 atactccgca ctcgtcccgc tcttcatcag ctacggattc gtgcgcacct ttccggcctt
    10501 catcgccgcc gcatccctca tctcggtctg cgagaccacg ggaagcccgc tgcgtgccac
    10561 gctgatgcac cagctcttcc gcgaagaggg cgcggtccgc gtccgagccc agatgaggag
    10621 cttcttcaac gtcggctaca tgctgggggc cgcagtggcg tccatcgcgc tgacggtggg
    10681 cacctcgcgc gcgttttatg cggtgctcct gctcaacgcg ctggcccagg cctgctgcgt
    10741 ctacatcgtc ttgtcggtgc gagtccctgc tgccgcgccc cgcgccgcac ccccgagaaa
    10801 ggggatgcgc ggggctctgt cgaacgtgcc attcctcgcc ttgacggctg tcaacggaat
    10861 cctggagctc cactacacga tattcacggt gggcgtcccc ttgtggatcg tgactcatgc
    10921 tcatgtcccg gcaggcttga attccgtcgt catcgctctc gacaccgtct tggtgatact
    10981 cctgcaagtt cccttgagcc gagggacggg cacgctggcc gagggtgcga atcagatgcg
    11041 gcgcggtgca tggttcatgg caatcgcctg cgccgtctac gcactcagtc agtcgagttc
    11101 agaagtggtc gcgatttgct ttctgcttgt gggcactgta attcttgttt tcggcgagat
    11161 atttcagtcg gccggcagct ggaccatttc gttcaaactt ccacccgccg gcaagcaggg
    11221 tgaataccag ggtgtatatg ctctggggcg aggtgtccga gaattcgcag gaccggctct
    11281 gctcaccgca ctgattgtgc ctctcgcctg gtgtggctgg atcgtcctca tggcgatttt
    11341 cctcgcactt tccaccctgg tcggaccgct cgcagaaatg gccgagcggc acgcgtcccg
    11401 agcggtcgtg gagccgactc cctctcgctg agcgggacca tttaatcacc cgctattttt
    11461 ctgcctcacc gaaagaatcg gagtttcagc tatgcagcgc ccccagtccc cctccttccg
    11521 gtcggtcgtg gccaagggag agatcgttcg tgtggccgga gcccacgacg cgctcggcgg
    11581 catcctggcc gagcaggcgg gcttcgatgc cgtgtggtcg tccagcctcg aggtgtccgc
    11641 tgcccgttgc ctgcccgatg ccagtgtgct cacgatgacc gagtacctgg aggccgccgc
    11701 caatatgcag aaggcgctcg gcattccggt catcgccgac tgcgacacgg gctatggcaa
    11761 caatctcaac gtcgtgcaca tggtccacga gtacgaggcc gccggcatta cggccgtatg
    11821 catggaggac aagctgttcc cgaagctgaa cagcttcgct ggcggcgacc agaccctcct
    11881 gagcaccgaa gagttctgcg gcaagatccg agcggccaag aaggcgcagc gcaccgacga
    11941 attctttgtg gtggcgcgta cggaagccct catcaacggt ctgagcgtcg atgtcgcact
    12001 cgagcgcgcg tacgcgtacg ccgaggcagg cgcggatgcc gtcctcatcc actccaagtc
    12061 caaggagaag gacgaggtcg aggagttcct caaccgctgg gacggctgcc gcccggtggt
    12121 cattgtcccc accacctacc cgaactggca catcgacgac atcgccaagg ccggcgcgtc
    12181 cgtcgtcatc tacgccaacc agggcctgcg tgcgacggtc tcctccctgc gcaagacctt
    12241 cgaatccatc cggcgtcacg gcgacaccac tgctctcgag gagagcatcg ctcccgtcaa
    12301 ggaagtgttc ggtctccaga agctcaagga ctggcaggcc ctggagaccg tctgagcccg
    12361 gctctgacca cccgagcgag gcggcccctc accggcccgt gccggtgaag tccgcccgct
    12421 cctgggcggg ttgagtacgc gcgtggtgct cggcctgcgc ggcgcggatc gcaagagcgc
    12481 gctcgcgtcg gccggatcgg cggcgcggcg gccggtcggg cgggcggggg agtagcggcg
    12541 ggagtgccgg gggccgggga gcctggggtc caggggcagc gggagccggg gagtagcccg
    12601 agcggccgac aggtgaggcg gtccttcggc tcaccgtgga agagttccag gcatgagcga
    12661 gtacccgtac gtgacgcacc cccggatcac ggtcctcggg gtccagcccg gcagcccgcc
    12721 ctttcgcatc gtggagatcg acggcgaggt cgtcggcacg gcgaagacgg tcacggacgt
    12781 cctggacgcg gccgtgatgg cgggcatcac cgtgcacgac ctcgacgacc cggacgccgt
    12841 gcgctgggtg ggcggcgaca agttcacctg gcgaccgcgc tgacgccgcc gaccgggccc
    12901 ggcgccgacc tagccgctgg gcgaaccgtg gcgcacgtgc cgctcagggc cgcccgggcg
    12961 ccggcacctc ctccccggcc ggcacgggac ccggcggtgt gccgtcgccg aacggccgcc
    13021 cgcccagctc ctcgcggtga tgcggcgtca gccacccgtc gaggtcgggg ccgagcggca
    13081 cgatgccggt cgggttgatg cccgagtgca cctggtagta gtgccgcttg atgtggtcga
    13141 agtcgatggt gtccccgaac ccgggcgtct ggaagagatc cctggcgtac gcccacagga
    13201 ccgggtcctc ggtcagcttc cggcggttgc acttgaagtg gccgtggtac accgcgtcga
    13261 accgcaccag cgtgctgaac agccggatgt ccgcttccgt gatcgtctcc ccgacgaggt
    13321 agcggcggct cgccagacgc tcggaggtca gctccagacg gcggaacaca tcgcggcacg
    13381 ccgcgtcgta cgcaccctgg tcgggcgcga aacccgcgcg gtacacgccg ttgttgacgt
    13441 cgcggaagat gccctccatc accgagtcga tctcgtcgcg cagcggctgc gggtacaggt
    13501 cgggcgcccc ctcgcggtgc agcgccgtcc actgggtggc gaagtccagg gtgatctgct
    13561 ggaagtcgtt cgtgaccagc ttcccgctcg gcacgtccac gagcgcgggc acgctgacgc
    13621 cgcccggaaa gccgctctca cgcgcctcgt aggcctcgct caggaagcgg atgccgagga
    13681 ccgggtcacg gccgccggga tccagcgtga agcgccagct ccggtcgtcc tggatcgggt
    13741 cggtgacccc cagggacagg gcgtcctcca ggccgagcag gcgccgggag accagtgagc
    13801 ggcccgccca ggggcaggcg cggctcacca ccaggcggta gcgccccgcc tcgacgggcc
    13861 agccgtcgcg gccgtcggcg gtcacccggt ccgcgaaatg gctcttggag cgcttgaact
    13921 ccttgtgccc gtacgaggcg ttgccctcgg ccgagccgcc ctcggccgag ccgccctcgg
    13981 ccgagccgcc ctcggccgag ccgccctcgg ccgagccacc cgccgcgggc tcgctctccg
    14041 ccgcgctcat gactggctcc cctcccgcgc gcaggagcgg gcgaccccgg agggcgcggc
    14101 ctgctcggcg gagcgtgggg gcggcgtgag atcgtagatc cgctcgatga gcaccgcctc
    14161 gttgcccgcg agcccggcgc ggcgcagcgc gtcgtcggcc tccgcgatcg gccccgccag
    14221 cagcgaggcc gcggcggcgg gaggaacctc ggacccgtcg gacagcgcgg cgcgcgcggt
    14281 gtgcagcagg cgcaagcagg cctgcgcggc gagcagttcc tcggacgtcg tgccggtcat
    14341 gtcgagcgac tcctctgcgc tggatggcgt ggcggcatcg cgacgatgcc acctccactg
    14401 tggcgcaagg gtctgacaat cgcgttccta cgcggccggt gagcggcgcg tgagccgcaa
    14461 agtgaggccg tccggcatga gggtcagacg ctcggcgacg cgcagccggt agccggggtc
    14521 ggcgtgcagg tcgtagcggc gcagcagcag acccagcacc aacgtcgcct catgcagcgc
    14581 gaactgacgt ccgatacagg cccgcgcgcc cgtgccgaac ggcttgaaga catgggcggg
    14641 cctcgcccgt accgccgaag gggcgaaccg gtcggggtcg aactcgtcgg gccgctcgcc
    14701 ccacgcggcc ggatcgcggt gcagcatcgt cgcgaggacc agcgcccacg ctccccggcg
    14761 catcgggtgc acgcccccca gcacggtgtc ctggcgggcc tcccgtgcga acgcgggagc
    14821 ggtcggccac agccgcagcg actcgtcgag cacccggcgc agatagcgca ctttggccac
    14881 ctgctcgtac gcgggctccc cctcggcgcc ccacacctcg tccacctcgg cccgcgcgcg
    14941 ggagagcact tccggggaac gcgacaagta gtgcagcgcg aaggagagcg ccccggacgt
    15001 cgtctcgtgc cccgcgacca ggaaggtgat gacctgtcgg cggatgttct ccggagacag
    15061 ccgctccccg gtctcggggt gagccacctc cagcatgcgg tcgagcagat ccccctgacc
    15121 tcccgaactg gacgcggcgc ggcgcgcggc gaccaccgcg tcgacggtgc ggttgaggta
    15181 cgccatgtcg gcgtcgttgc gccgcaccgc tccgcgcagc agcaccggcg tcagcagcgg
    15241 cggaacgaca ttgcgccgct gtgcgaagga gagtgtgccg accatggccc gcacgaaggg
    15301 atgcggcgcc gaccgctcga aggagccgaa gtcatggccg aaacccgtgc gggcgatcgt
    15361 ctccagcgtc agcttcgtca tgtcgcccgg cacatccacc gcccggcccg ctgcctccca
    15421 ctcgtcccag cgcgcggtca gccggcgcgc cacgtccagc atcagcgggt ggtagcccgc
    15481 catcgcctcg cggctgaacc cgggggcgag tatgtcgtgc gccagctgcc agttgggctc
    15541 gtggttgtac gccgtgaaga gcccgtcgcc cgcgaccgga cggaggttgg ccacccccag
    15601 ccccacatgc ttggcgaagc gcgtctcgtc cgccaggtcg gcggcgagag cggcgcccca
    15661 cacgaagacg aactccttgc cgaacgcctt gcgccggaag atcggcccca gcctgcgccc
    15721 catccgcatc gagtcctgca acggcgtccg cacgtcggcg ccgaggacgt cgccgaggaa
    15781 cggcaggcgg cgcggcgggt gcggtatccg gtgcagttcg ggccagccca gctccgcgct
    15841 gcggaagccc ttgggcggcg ggcccaccgg ctccgtcggc cccgccgcgg accgcgtcgt
    15901 ctgcgccatg tgcccatctc ccttgcgcgg cgggcccatt ggggcctgtt atacgtgggt
    15961 tcaataagag ttcccagtct ggggccgcta ttgaattcac gtcaagtaag gtgcccgcat
    16021 ggccgcgaac ccaccggagc gcacgcgccg cagaatgagc accgaggagc ggcgtgagca
    16081 gctgctttcg gtcggggcgc gactgttcgc acagaagccg tacgacgatg tgtggatcga
    16141 gcgggtcgcg gagatcgcgg gcgtctcacg cggcctcctg taccactact tccccgccaa
    16201 acgggacttc ttcgccgccg tcgtgcagcg cgagagcgag cgcatgctgc gcctgacggc
    16261 ggccgtgccc ggcctcccgg tgcgggagca gatcagcgcc gggctcgacg cgttcctcgg
    16321 ctatgtggag agccacgcgc agggtttccg cgccttccac cgggcggagg cggcgggcga
    16381 cccgctggtc cgcgaggtct acgggcgggg cctcgccgcc caggagcggc agatcctcgc
    16441 ggccctcgcg gcggacccgg acgcggcgga cctcatccgg gacccgcccg cgctgcgcct
    16501 cgcggtgcgg ggctggctcg ccttcatggt cgccgtctgc ctggagtggc tggccgaacc
    16561 ggagctgacg cgcgcacagg tacgggacct ctgcgccagg gcgctgctgg gcgcgatcac
    16621 gcgctgagcc gccccgcgct gagccgtccc gcgctgagcc gtcgtcacgc gctgaggcgc
    16681 agcgcctccc gcagtcgggc gggggtggtg aagaggtggc cgcggatgcc gctcgccccg
    16741 gcggcacgga tgttgtcctc gcggtcgtcg acgaagagca cccgctccgg ctcggcgccc
    16801 agggcgtcca ggcaccagcg gtaggcgccc ggctcgggct tggcgtggcc gatgcggcag
    16861 gagaagccgc gcacctggaa gtgcttgagc caggggtgcc gtccttcgta gtggacggcc
    16921 agctcctcgg ggatgttgga gagcagcgcg atcggcctgc ccgccgcggc cagttcctcg
    16981 accagcgcga ccatcgtgtc gtcgacggag ctccagctgg cgatgtccgc ctcgatgagc
    17041 cgcgcgatcc ggtgcggccc gaagtccgtg ccgagcgcgt cggccacgcc ccgccagtag
    17101 tcgaagccgg ctatgtcccc acggtcgtac ggctgacgca gcccccagta cgcctcccag
    17161 aaccgcgact cgggaacgtc ggcgagggcg gtcagacgcg ccttgccgtc ctcggactgg
    17221 tggcgcgcga tgacgccgaa catgtcgaag agcaggatgt cgtgcgcggg gccattcacc
    17281 gggtcgttca tcagatcact cacaggtcat acctttcgta cggtcacgcc cgccgcggcc
    17341 agtgcgtcgg tctcc
//
