LOCUS       NZ_CP029617            22612 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 01529 chromosome, complete genome.
ACCESSION   NZ_CP029617
VERSION     NZ_CP029617.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 01529
  ORGANISM  Streptomyces sp. WAC 01529
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. May-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 202.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945545.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:27:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,297
            CDSs (total)                      :: 7,207
            Genes (coding)                    :: 7,110
            CDSs (with protein)               :: 7,110
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 33 of 97
            Pseudo Genes (incomplete)         :: 81 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7872675
            Orig. end                         :: 7895287
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029617.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22612
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="32"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22612
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22612
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12612](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12612)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            441..1262
                     /locus_tag="DMA15_RS34595"
                     /old_locus_tag="DMA15_34585"
     CDS             441..1262
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="DMA15_RS34595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="DMA15_34585"
                     /product="DUF4239 domain-containing protein"
                     /protein_id="WP_125516596.1"
                     /transl_table=11
                     /translation="MIITILVAALALIGGLTAHWVLRRRLEETETPSLTIRDFVLPLQT
                     LTVFVLAFVLVTASTSNGKADEAARKEAGVVDHIFEVADYAPASQRQRLQADVVCYARA
                     VRAYEWPAMADGRGAQQPSTWTTDFRAALKQMGTDASAFNMLVSADKERSEARQTRIAE
                     STPAIPSAVYWLTLAALAFLVVALALCLPRKNTMLVTSGLIVLTALLTTVLLVIRDVER
                     PFSGAIQVSPTAITGVVDDITDDYTTAYGDGRLPCTDEGVKTKATRATTPP"
     misc_feature    1276..1292
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.07"
                     /tool="antismash"
     gene            1621..3138
                     /locus_tag="DMA15_RS34600"
                     /old_locus_tag="DMA15_34590"
     CDS             1621..3138
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037926.1"
                     /locus_tag="DMA15_RS34600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34590"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_125516597.1"
                     /transl_table=11
                     /translation="MDADHVRLVVAAQRGDERAREALVAAYLPLLYNIVGRALSGHADV
                     DDVVQETLLRAVRDLPALRAPESFRSWLVSITLRQVNTYWQRQRTLADRTTLIDEALPL
                     PDAAAPLEDTTILRLRMSEERGQAVEASLWLDPEHRVLLSLWWQECAGLLSRQDIADAT
                     GLGVSHTGVRLQRMREQLELSRTIVAALAADPRCPGLSAALSGWDGARTSVWRKRIARH
                     TRDCATCTATAAERVPAELLLSGLTPLAVPAALLGALVAKGLLSGTTVTTAAAASATGT
                     ATGGGALLGKLHAVTAHPIAALATGAVLVTGTATYVAWPEPEHRTPGVAAAPTAGTTTP
                     APSATPAPSTTPTPSTTPAPSVTPSPSGPAVVPLGVRSLESVDRPGQFLTYDGDFATLS
                     SGEAAFTVSKGLADSRCVTFRAADGRYLRHHYLRLRLSADDGSRLFREDATFCPRPGTV
                     DGSVTLYAHNYPGSALRPRDGSIRLDGFNGTRTFTGQASFVVRAPLT"
     misc_feature    1930..1932
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3320..5701
                     /locus_tag="DMA15_RS34605"
                     /old_locus_tag="DMA15_34595"
     CDS             3320..5701
                     /GO_function="GO:0046556 - alpha-L-arabinofuranosidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0046373 - L-arabinose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017241810.1"
                     /locus_tag="DMA15_RS34605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34595"
                     /product="non-reducing end alpha-L-arabinofuranosidase
                     family hydrolase"
                     /protein_id="WP_125516598.1"
                     /transl_table=11
                     /translation="MTRHTDEPRKGLHRLRRPRRTLAIGLTASALVAGVVTLLPTSAGA
                     ASLEAEASSSGRYFGTAIAAGRLSDATYTSIADREFNMITPENEMKWDAIEPSRDNFRF
                     AAADKIVNRSLERGQRLRGHTTVWHSQLPDWVKAINDPNTLRGVTNNHIKTTMSRYKGK
                     IYAWDVVNEAFQDGGSGALRESVFKKVLGSGFIEEAFRTARAADPAAKLCYNDYNIEDW
                     SAAKTQGVYRLVKDFKARGVPIDCVGFQSHFGAGGPPASFKKTLDSFAALGVDVQITEL
                     DIAQASPTHYASAVNACLGVKRCTGITVWGVRDSDSWRADEKPLLFDAAGKPKPAYDAV
                     KKAFDAGSGTTPADPGDGTGQIKGVPSGRCVDVPGSSTANGTQVQLRDCDGQSNQSWTR
                     TAAKQLKVFGDKCLDAKAKGTTNGTEVVIWDCNGGTNQQWNINTNGSISGAQSGKCMDA
                     IGAGTSNGTKIQLYTCADVGNQKWTAPSGSAGGTCALPSTYKWSSTGALAKPANGWASL
                     KDFTHVPYNGKHLVYGSMSTGTSYGSMAFAPFSDWSGMGTATQTKMNQNAVAPTLFYFA
                     PKKIWVLTYQWGASPFSYRTSADPADPNGWSAPRPLFTGSLPDSRTGPIDQTLIGDDQN
                     MYLFFAGDNGKIYRASMPIGNFPGNFGSSYTTVMSDTVKNLFEAPQVYKVQGQNQYLMI
                     VEARGANENRYFRSFTATSLNGTWTPQAATESNPFAGKANSGATWTNDISHGDLIRSNP
                     DQTMTVDPCHLQLLYQGKDPKSDAPYDALPYRPGVLTLKR"
     gene            5755..7944
                     /locus_tag="DMA15_RS34610"
                     /old_locus_tag="DMA15_34600"
     CDS             5755..7944
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003982637.1"
                     /locus_tag="DMA15_RS34610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34600"
                     /product="carbohydrate-binding protein"
                     /protein_id="WP_240660096.1"
                     /transl_table=11
                     /translation="MNISPYTRTGSRRRGLHRRRRGAIALLLAVPAAAVPYLLLTQDDS
                     QAAKARPSAAAPYKWKNAQVVGGGYVSGLVFNQRERGLLYARTDMGGAYRWDVGAEKWI
                     PLTDWLGEKDWNLLGIDSLATDPVDPDRLYLGAGTYTNDWAGNGAILRSTDRGRTFKRT
                     ELPFKLGGNEDGRGAGERLVVDPADHSNLLLGSRKNGLWRSTDYGATWRQVESFPVKGG
                     AGSGAGISFVTYGPKGSDTVYAGVADKSTSLYRSTDSGATWRAVAGQPTGQLPQHGVVT
                     GDGTLYVTYTDNLGPNGVTGGSVRKYTPSGGGWKDVSPSQGSYGFSGLAVDPRKPSTVM
                     VTTLGRWYPEDEIYRTTDGGSTWKALADKSVRDASGAPYVGTHTGHWMTALAIDPFDSG
                     HVLYGTGNGIWRSEDADAGTSHWTIGAKGLEETAILDAIAPPGGATVLTSMGDQGGFRH
                     TDLTRVPPGRMRNPLMSNSTDIDYAASKPSVMARVGTGGKQDGAYSTDGGVTWRGFAAE
                     PVADAHSGRIALAADGSTLVWTQSGQSPYRSTDKGATWSKVRGLGTGAEVVADRSSART
                     FYSLTGGTLYASTDGGATFTARATGLPADGRLKALPGRAGELWIAGGGKGLLHSTDGGG
                     TFTRLTSVTSASAVGFGKAAPRASYQTLYLIGTVKDVTGVFRSTDKGATWTRVNDNAHQ
                     WGAIGSQGVVTGDPDTYGRVYIGTNGRGLQYGDPS"
     gene            complement(8134..9996)
                     /locus_tag="DMA15_RS34615"
                     /old_locus_tag="DMA15_34605"
     CDS             complement(8134..9996)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003986676.1"
                     /locus_tag="DMA15_RS34615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34605"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_125516599.1"
                     /transl_table=11
                     /translation="MTTAPGIEGPRPLTGPADGSHEPDEDTGPERAWASQRALMTHLSP
                     QRWRMAAGVLLGLVGSVMGLAQPLAAKRVMDDMSQGRPTTGPILMLSLLVVTGAVLAGL
                     GHYVLQRSAESMVCAARCRLTERLLRLRVPVVERTEPGDLIARVTSDTTLLRQTAPQAV
                     SAAVTGTLVTAATVVIMGFLDAVLLCVTLGVIAFVGVIVAVVAPRIGRATRQVQDAVGH
                     IGGALERVLGAFRTVKASGAEHWETQALRRAAEHARRRGTRAAAWEAVSATASAVVVQV
                     CFLVVLGVGGARVTAGTISVSTLVAFLLYLFALAPRIGQLVEGVSQFQIGSAAAVRIEH
                     IETLEAEQVKPEHTTEHTRGATARGGSPAMAAEDGRSPLDVTFRQVRFAYRPGLPRVHH
                     EVSFTVPGRGLTAIVGPSGAGKTTVFSLIERFYEPDAGSILVGGKDTRQWPLSQLRASI
                     GYVEQDTPVLAGTLRDNLTLGASDPSGEELAQVLRMARLDTLTDRLPHGLDTHVGHRGS
                     RLSGGERQRVAIARALLRRPRLLLMDEVTSQLDAANEAALRDMITDAARSTTVMVIAHR
                     LSTVTTADRIIVMEAGCVRAIGTHGELIKRDALYSELAHTQLLN"
     gene            complement(10001..10417)
                     /locus_tag="DMA15_RS34620"
                     /old_locus_tag="DMA15_34610"
     CDS             complement(10001..10417)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047207.1"
                     /locus_tag="DMA15_RS34620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34610"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_125516600.1"
                     /sec_met_domain="PF13471 (E-value: 3.1e-26, bitscore: 90.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPEALPYDPCSVPVGRRFAARAAVGCAHVLATMPPGRIRTILA
                     RLRRGARPATLSEAEKARETVLAVSLSAGGQKGCLPRSLATVLLCRWYGHWPTWCVGVR
                     SRPPFAAHAWVEAEGVLVGEDASPTYFQRFFTVE"
     gene            complement(10460..10732)
                     /locus_tag="DMA15_RS34625"
                     /old_locus_tag="DMA15_34615"
     CDS             complement(10460..10732)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047209.1"
                     /locus_tag="DMA15_RS34625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34615"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_276314382.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.4e-18,
                     bitscore: 63.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-14, bitscore: 52.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILVHALRPGVLMTETEYGVALLDQKSAEYWTLNPTAALVLRTLL
                     DGRARGAERAVEALTTQYDDIGADEAAKDVDAIVGELRSAGLLTT"
     aSDomain        complement(10466..10720)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DMA15_RS34625_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="2.90E-20"
                     /identifier="RREFam002.1"
                     /label="DMA15_RS34625"
                     /locus_tag="DMA15_RS34625"
                     /protein_end="89"
                     /protein_start="4"
                     /score="63.1"
                     /tool="antismash"
                     /translation="HALRPGVLMTETEYGVALLDQKSAEYWTLNPTAALVLRTLLDGRA
                     RGAERAVEALTTQYDDIGADEAAKDVDAIVGELRSAGLLT"
     gene            complement(10729..12612)
                     /locus_tag="DMA15_RS34630"
                     /old_locus_tag="DMA15_34620"
     CDS             complement(10729..12612)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010047211.1"
                     /locus_tag="DMA15_RS34630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34620"
                     /product="lasso peptide isopeptide bond-forming cyclase"
                     /protein_id="WP_125516601.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.4e-37, bitscore:
                     128.1, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATYLSLQTAPAWFIALPDTAAAAPFAARAHRYATRSLLHASGRP
                     WLVGRWEEPAAVLGRCGGTRIAVIGEHAVTEHYLEQAAAATGPASLSALDRAARRPGSF
                     HLVASVGGRVHVRGGIVNLRRVFHTETTACGPVSVASDRADVLAELIDADLDERRIALE
                     LLTSGAPYPLSAPPLWRGLRAVPAGHCLTLDADGRTTMRRWWSPPDPVLPLAEGARQLR
                     EALTEAVGVRTRGRELVTADLGGLDSTALCCTAARGDTKVVAYTAALHDESGDDVHWAR
                     RTVQELQGIEHHVVPAEDTAMTFDGIDTLHDILDTPSIITVDRNRRMGIVEMAAARGSH
                     LHMTGLGGDELLAGTPARLHSLLLTHPSTALRNIRGYAAKYQWPRRATLRQLLDRRSYR
                     SWVGRVARDLTGPPPGTNTPLLDWSTPPRMAPWATPDAITAAREQIGAALAGIEPRGRG
                     HGEHRELVAMDGISQWTRHIGQMAAPLGIAVAAPYYDTRVIETCLAVRPQERITPWRYK
                     PLIVEAMRGVVPETSRTRDTKANATFEEEVGLREHRRRLLALCDDSRLAQLGLIDANIL
                     REWCRRSLAAETESYLLHPTIACEVWLRSREMTPPRHGNAVPAQPLADRKE"
     misc_feature    complement(11524..11526)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12762..12869)
                     /locus_tag="DMA15_RS36890"
     CDS             complement(12762..12869)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039305.3"
                     /locus_tag="DMA15_RS36890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_164551888.1"
                     /transl_table=11
                     /translation="MTYERPTLTKAGSFRKVTGIKNTGPKDVLGGKQFL"
     misc_feature    complement(12866..12879)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.85"
                     /tool="antismash"
     misc_feature    complement(12969..12982)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.03"
                     /tool="antismash"
     misc_feature    13229..13245
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.79"
                     /tool="antismash"
     misc_feature    complement(13303..13312)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            13488..15053
                     /locus_tag="DMA15_RS34640"
                     /old_locus_tag="DMA15_34630"
     CDS             13488..15053
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (99-261). E-value:
                     4.4e-20. Score: 64.3. Matches aSDomain:
                     nrpspksdomains_DMA15_RS34640_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020138545.1"
                     /locus_tag="DMA15_RS34640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34630"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_346428940.1"
                     /sec_met_domain="PF00561 (E-value: 1.9e-29, bitscore:
                     101.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGAPAGAAEGDGPDLSRFYDQKFAWASCKVLAGVLEFPGDMQCGK
                     VTVPLDYAAPEKGTIDLFLNRIPASGKKRGSLFLNFGGPGSAGVPGVAGRAKEFGDLTK
                     SYDVVGFDPRGVGFSSPATCGDGSDQPSSALDGDESTAADVMDKFTKAYEECKKHSGPV
                     LQHMGTINVSRDLDVMRHNLGDKKLNFLGFSYGTRLGAVYTAQFPKNTGRLVLDGVDTL
                     TEPLTESSLVGAQGQQTALDNFVTWCARNEGCPLGANPRDAKENIAKLVTTLKAKPVVA
                     GNGQEFTGDDLVHSLGEALYGRGNWPYLSQALTSLITDDDPRSLLRISGSLLPPDPDPD
                     TGPTGSGEEGPGGISPVRVMLRTAQEEEPVKPPPDDNSGIALTAVNCADDPDRLTVADF
                     ENDAKFERMARDYAKASPIFGPSALLQVRMCAGFPAGTDFVRGIKNVHTPKFLLVGTRG
                     DPATPYRWTVETAKRLGDSAVVLDNKGDGHGAYFSSKCVKQKVDDFLLYGSQVKSGSSC
                     GSDK"
     aSDomain        13785..14270
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS34640_Abhydrolase_1.1"
                     /evalue="4.40E-20"
                     /label="DMA15_RS34640_Abhydrolase_1.1"
                     /locus_tag="DMA15_RS34640"
                     /protein_end="261"
                     /protein_start="99"
                     /score="64.3"
                     /tool="antismash"
                     /translation="GDLTKSYDVVGFDPRGVGFSSPATCGDGSDQPSSALDGDESTAAD
                     VMDKFTKAYEECKKHSGPVLQHMGTINVSRDLDVMRHNLGDKKLNFLGFSYGTRLGAVY
                     TAQFPKNTGRLVLDGVDTLTEPLTESSLVGAQGQQTALDNFVTWCARNEGCPLGANPR"
     gene            complement(15107..16399)
                     /locus_tag="DMA15_RS34645"
                     /old_locus_tag="DMA15_34635"
     CDS             complement(15107..16399)
                     /EC_number="2.5.1.76"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03844.1"
                     /locus_tag="DMA15_RS34645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34635"
                     /product="cysteate synthase"
                     /protein_id="WP_125516603.1"
                     /sec_met_domain="PALP (E-value: 4.5e-28, bitscore: 97.2,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGAPCARDGSYQLVCTGCGLRLVDDGTVLECPACADGSLLRTD
                     YGSLRFKPEPGASGIFRYGFWLPACREVPGSSAPHVFRSERLAMAVGLSDLWISFSGFW
                     PERNCRMESGTFKELEAYSVLARVPEGAGTMVVASAGNTAAAFLSACRNFPFPCVLVVP
                     ESALPALNGLPGTGSCARVIALKGADYNQAIAYSKRIIELSPEFFAEGGVRNVGRRDGL
                     ATVTLAAYEAMGRLPDYYVQAVGSGAGAIATYEAATRIARSATTATTALPRLILCQNTA
                     FAPIHDLWNHKTPHSFSAPPPPTEVYAPELVNSAPPYWAHGGIRDILTRTRGDVLTAGR
                     RAADEAAAAFEELEGVDIERPAAVALACLRQAVAVRRIPRDARVLLNVTGGGRRRIHAS
                     TVSRRHQHPPIRLVSMESDPEAVMSRTASRR"
     gene            complement(16396..17004)
                     /locus_tag="DMA15_RS34650"
                     /old_locus_tag="DMA15_34640"
     CDS             complement(16396..17004)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017778.4"
                     /locus_tag="DMA15_RS34650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34640"
                     /product="cysteine dioxygenase family protein"
                     /protein_id="WP_125516604.1"
                     /transl_table=11
                     /translation="MVGVPSRPDAVEGNARLADLVAVVRETVRSSFTAAQRVARTSERL
                     RPFLAAPGLLAAHQREGRADGYRQHLLHAEPGGLFSVVALVWLPGQETPVHDHVSWCVT
                     GVYEGREVEERYRIASTGPGERLVATERLVNSVGDVNGFVPPGDIHVVRNPGPGPAISL
                     HVYGADISRLGTSVRRIYPAHLIDIASPAPSTNDRRSAR"
     gene            17416..18804
                     /locus_tag="DMA15_RS34655"
                     /old_locus_tag="DMA15_34645"
     CDS             17416..18804
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013739.4"
                     /locus_tag="DMA15_RS34655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34645"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_125516605.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.3e-06, bitscore:
                     26.6, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2e-07, bitscore: 29.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLSRKQLLKIMGGTAVAAGMPLGAAEASASQAPTRKRDVCIVGG
                     GASGTYTAMRLRQLGKSVLLVERSDRLGGHTETHRDPVTGDTTEIGVVLWRDLPAVRGY
                     FKRLGVPVEVFSGHESKPPKYADFRTGAPVNAPASPPDLMTSYFKVLKKYPYLATGYDL
                     PDPVPAELYMPFAKFAAKHGLEALVPLLVRVMMGFGDLLTLPTLYVMKSFDIDMVSRLL
                     NGGSFLTTKSGNNSELYEKAATHLDDDVLLNAELIRVNRSRDLVTIRVGTPQGLQTILA
                     KKIVFTAPPTQRNLAPFDLDRTERTLFSRFRPHFYYTGLVRLPGVPDTMTVQNLGSTPP
                     FHMPALPALYHIQSSGVPGLHHVKYGSTVPLTYRQVRANIHADIKRLVAAGTIPATTVK
                     LSTLKSHSPYGMSVSADDIANGFYRRLNALQGRNRTFYNGAAFHAHDSSLLWQFTERLL
                     PNLT"
     gene            complement(18801..19310)
                     /locus_tag="DMA15_RS34660"
                     /old_locus_tag="DMA15_34650"
     CDS             complement(18801..19310)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009079505.1"
                     /locus_tag="DMA15_RS34660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34650"
                     /product="2'-5' RNA ligase family protein"
                     /protein_id="WP_240660098.1"
                     /transl_table=11
                     /translation="MPDAAPLLDAAWRIDPALVRRGVPAHVSLLYPFVPESALTDRDEK
                     GVRSLAASFPAADLLLEEVVTESGFVAVTVPGLQTIVDAFRTRWPGLRPYKGRFGAQPA
                     AHVTVAMGADTPAAAAQVRAAIGSLLPLRTRATAVQLVALTEAGWQPRFAVPLGTSPSA
                     ALRNTL"
     gene            complement(19480..20379)
                     /locus_tag="DMA15_RS34665"
                     /old_locus_tag="DMA15_34655"
     CDS             complement(19480..20379)
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003995565.1"
                     /locus_tag="DMA15_RS34665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34655"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_125516607.1"
                     /transl_table=11
                     /translation="MTAVVIHALSASDAHLFDVLPDPLGAREAHRRTQFRPDWKRVALR
                     DGEVVARGAWWGGPDDSEPVNINWFDVAEGEEEAGAELLRSAPWQVELEINLPGGWREE
                     TDLRAGAESRFAAARAAGYELLVERFLYRWTPERGLPERPGRLRFSAEPDDTVFFDALR
                     RIHSVTLDAHALRAIGEGGLDQAAQEELDFFHWCPSPREWWQTAHTPEGDLAGIHIPAH
                     NPSGPTIGFIGVVPEQRGRGYAYDLLAECTHLLVEQGAEFIGGATDQANFPMAANFARA
                     GFPVVRERINFHPAGRAT"
     misc_feature    complement(20403..20417)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.98"
                     /tool="antismash"
     misc_feature    20404..20418
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     misc_feature    complement(20639..20653)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            20843..22183
                     /locus_tag="DMA15_RS34670"
                     /old_locus_tag="DMA15_34660"
     CDS             20843..22183
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330842.1"
                     /locus_tag="DMA15_RS34670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_34660"
                     /product="cation:proton antiporter"
                     /protein_id="WP_125516608.1"
                     /transl_table=11
                     /translation="MTIADVVFAWLGVGALVAAVLPRVVAGRPVSLPVVFLVSGVVVYA
                     LPLPLPVVDPVEHRLVTEHVTEVCVIIALMGAGLALNRPVGRRLWASTWRLLGITMLLT
                     VVATAVVAWWLLEWPPAAALLLAAVLAPTDPVLASEVRVGEPTEEKHDEDEVRFALTSE
                     AGLNDGLAFPLTYAAIALAAAAGSGWSAEWIGTWAAHDVAYKSVVGVLGGLLIGKLLGW
                     LFFRTRSSVLRLADHREGFVALGATFLAYGVTELAGGYGFLAVFTTACAVRAAERAHGF
                     HNVLHDFVEQVERLLTAVLLFLLGAFIALGGLAPLTWRGAATGLLLLLVVRPLAGWAGL
                     LGGRLRGWERWVVAGYGIRGIGSLYYLAYALGQQDFAVAERELWAVVTFTVLVSVVLHG
                     VTAGPVVSRLDRRRPAPPPEPGEKRGDETARVEEAPRPAVGPAAGDG"
     misc_feature    22211..22224
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.07"
                     /tool="antismash"
ORIGIN
        1 gttcgccgcg ggagtcctcg ccgccgacga gcacgagccg atcggcagcg cctcaagtcg
       61 tcgacaacaa ccgcatcagc gacctcgtcg gatacgacat cctcctcctc gcggacatcc
      121 tccaggacct gccggaccgg aagggcacgg gctacaacca agaccagctc gaccagctcc
      181 tggatgcgac cgcgctcccc gagccgatcg aacttcccgc cgatggcgcc gcgagaacgc
      241 atgggcccaa gagccgaccg aggactggcg gaaggccctg gactggctga agcgaaactc
      301 cttgccgcct tgatcctcgg aggattcagc acctgaaagg gtgatcgcgc gtacgacggc
      361 cgggtcgctg aacaggtacc acgcgatcag ggctagatga tcggtttcgg cgcgttggct
      421 cgaaacgaaa caggtgtcgc gtgatcatca ccatccttgt agcggccctg gccttgatcg
      481 gcgggctgac cgcccactgg gtgctgcgcc gccgcttgga ggaaacggaa accccctccc
      541 tgacgatccg ggacttcgtt ctacccctgc agaccctgac cgtgttcgtc ctcgccttcg
      601 tgttggtgac cgcttccacg tccaatggca aggcggacga ggcggcccga aaagaggccg
      661 gcgtggtgga ccacatcttc gaggtcgccg attacgcccc cgcttcgcag cgccagcggt
      721 tgcaggccga tgtcgtctgc tatgcccgtg cggtacgcgc ctatgaatgg ccggccatgg
      781 ccgacggccg cggcgcacag caacccagca cttggaccac tgacttccgt gccgccctca
      841 agcagatggg cactgatgcc tccgcgttca acatgctggt ctctgccgac aaggaacgct
      901 cagaggcccg ccagacccgc atcgccgagt ccactccggc catccccagt gccgtgtact
      961 ggctcaccct cgccgccttg gccttcctgg tggtcgccct agccctgtgt ctcccacgca
     1021 agaacaccat gctcgtcacc agtggcctca tcgtcctcac cgccctgctc acgactgtcc
     1081 tgctcgtcat tcgggacgtg gagcggccct tcagtggcgc cattcaggtc tctcccaccg
     1141 ccatcaccgg cgtcgtcgac gacatcaccg acgactacac caccgcctat ggcgacggcc
     1201 gtctgccctg caccgacgaa ggcgtcaaga cgaaggccac gagggcaaca accccgccgt
     1261 gagaagcgtg cactgtcgca aaatgctcgc aagggctggc gggggcggcg gccaggaaac
     1321 agccaggggg cgcgtggttg gtggcggtgt tcatgtggtc gctctcccgc gacaccttca
     1381 gcaggctcta cgcacgagcg ttcatcctga acgtgcaggt cacgggggtg gggtcggcga
     1441 tcgcggccag gcccgctgcg cgcagccgac cgttgcggcg actccggcgt cggccgagaa
     1501 gggccactgg cccgcgcgtc gcatgatcgt cgcccctggg ggatgacgcc gtgggccaca
     1561 cggttagggt gtggcgccgt actcggcgga tcactctcct gaacagatgg gaccgggctc
     1621 atggacgcgg atcacgtgag gctggtcgtc gcggcgcaac gcggtgacga gcgggcgcgc
     1681 gaggcgctcg tcgccgcata tctgccgttg ttgtacaaca tcgtcggacg ggcgctgagc
     1741 ggccatgccg acgtggacga cgtggtccag gagacgctgc tgcgcgcggt acgcgacctg
     1801 cccgcactgc gggccccgga gagcttccgt tcctggctgg tgtcgatcac gctccggcag
     1861 gtcaatacgt actggcagcg gcagcgcaca ctcgccgacc ggaccaccct catcgacgag
     1921 gcgcttccgt taccggacgc cgccgcccct ctggaggaca cgacgatcct gcggctgcgc
     1981 atgtcggagg agcgcggaca ggcggtcgaa gcgagccttt ggctcgaccc ggaacaccgg
     2041 gtgctccttt cgctgtggtg gcaggagtgc gccgggctgc tcagccgcca ggacatcgcc
     2101 gacgcgacag gcctcggcgt ctcccacaca ggggttcgtc tgcaacgcat gcgcgagcaa
     2161 ctggaactga gccggacgat cgtcgccgcg ctggcggccg acccgcgctg ccctggcctg
     2221 agcgcggccc tctccggctg ggacggcgcg cgtacgtccg tgtggcgcaa gcggatcgct
     2281 cggcacacgc gcgactgcgc gacatgtacg gcgacggcgg ccgagcgggt gccggccgag
     2341 ttgctcttgt ccggcctcac gccgctggcc gtgccggcgg cgctcctcgg ggcgctggtc
     2401 gcgaagggct tgctgtcggg tacgacggtg acgacggcag ccgccgcgag cgccacgggc
     2461 acggcgactg ggggcggcgc tctgctcggc aagctccacg cggtgaccgc ccatccgatc
     2521 gcggccctcg ccactggcgc ggtgctcgtc accgggaccg ccacgtacgt cgcctggccc
     2581 gaaccggagc accggacgcc cggtgtcgcc gccgcgccga cggccggcac gaccaccccg
     2641 gctccctcgg ccaccccggc tccctcaacc acccccactc cgtcgaccac cccggctccg
     2701 tcggtcacgc cgtcaccgtc gggtccggcc gtggtcccgc tgggcgtacg gtccctcgag
     2761 tccgtggacc ggcccggcca attcctcacg tacgacggtg acttcgcgac gctcagcagc
     2821 ggtgaggccg ccttcaccgt cagcaagggg ctcgcggaca gccggtgtgt cacgttccgt
     2881 gcggccgacg gccggtatct gcgccaccac tatctgcggc tgcgcctgag cgccgacgac
     2941 ggcagccggt tgttccggga ggacgccacc ttctgcccgc gccccgggac ggtcgacgga
     3001 tcggtgaccc tgtacgcgca caactacccg ggctccgccc tgcgcccccg cgacggatcg
     3061 atccgcctcg acggcttcaa cggcacgcgt accttcaccg gccaggcatc tttcgtcgtc
     3121 cgcgcgccgc tgacgtgagc gcggggaacc gctgacttca taaccgcgcc ccgcattacg
     3181 tttttccgct gcgagatccc tcactgcgcg ggcgcgcaca tttttcgtta cgccgtcccg
     3241 ccttccccgg cctcctcttc aggggtgccc cttcacaggc atcccccgct gacctgtccc
     3301 ctgaagaagg ccactcccca tgaccagaca caccgacgaa ccccgcaaag gcctgcaccg
     3361 cctccgccgg ccccgcagga cactggcgat cggcctgacg gcctcggcgc tcgtggccgg
     3421 tgtcgtgacg ttgctcccca cctccgccgg ggccgcgagc ctggaggccg aggcttcctc
     3481 gtcgggccgg tacttcggca ccgcgatagc cgccgggcgg ctgagcgatg cgacgtacac
     3541 gtcgatcgcc gaccgggagt tcaacatgat caccccggag aacgagatga agtgggacgc
     3601 gatcgaaccg tcccgcgaca acttccggtt cgcggccgcc gacaagatcg tcaaccggtc
     3661 cctggagcgc ggccagcggt tgcgcggcca caccacggtg tggcactcgc agttgccgga
     3721 ctgggtgaag gcgatcaacg acccgaacac gctgcgcggc gtcacgaaca accacatcaa
     3781 gaccacgatg agccgctaca agggcaagat ctacgcctgg gacgtcgtca acgaggcctt
     3841 ccaggacggc ggcagcggtg cgctgcgcga gtcggtgttc aagaaggtgc tcggcagcgg
     3901 cttcatcgag gaggcgttcc gcaccgcccg cgcggccgac ccggccgcga agctctgcta
     3961 caacgactac aacatcgagg actggtcggc cgccaagacc cagggcgtgt accgcctggt
     4021 caaggacttc aaggcacgcg gtgtccccat cgactgcgtg ggcttccaga gccacttcgg
     4081 ggcgggcggc ccgccggcca gtttcaagaa gaccctcgac agcttcgcgg ccctcggcgt
     4141 cgacgtgcag atcaccgaac tggacatcgc ccaggcgtcc cccacgcact acgcgagcgc
     4201 ggtcaacgcc tgcctcggcg tgaagcgttg taccggcatc acggtgtggg gcgtccgcga
     4261 cagcgactcg tggcgcgcgg acgagaagcc gctcctcttc gacgcggccg gcaagccgaa
     4321 gcccgcgtac gacgccgtca agaaagcgtt cgacgccggg tcgggtacga ccccggccga
     4381 cccgggcgac ggcaccggcc agatcaaggg cgtgccctcc ggccgctgcg tcgacgtccc
     4441 cggctcctcg accgccaacg gcacgcaagt acagctgagg gactgcgacg ggcagtcgaa
     4501 ccagagctgg acgcgcaccg ctgccaagca gctgaaggtg ttcggcgaca agtgcctgga
     4561 cgcgaaggcg aagggcacga cgaacggcac cgaggtggtc atctgggact gcaacggcgg
     4621 cacgaaccag cagtggaaca tcaacaccaa cggttcgatc tccggcgccc agtccggcaa
     4681 gtgcatggac gcgattggcg cgggcacgtc caacggcacc aaaatccagc tgtacacctg
     4741 cgccgacgtc ggcaaccaga agtggaccgc cccctccggc tcggccggtg gcacgtgcgc
     4801 gctgccgtcc acgtacaagt ggagctcgac cggcgccctg gccaagcccg ccaacggctg
     4861 ggcctcgctg aaggacttca cccacgtccc gtacaacggc aagcacctcg tctacgggtc
     4921 gatgtcgacg ggcacctcgt acggctcgat ggcgttcgcc ccgttcagcg actggtccgg
     4981 catggggacg gctacgcaga cgaagatgaa ccagaacgcg gtcgcgccca ccctcttcta
     5041 cttcgcgccg aagaagatct gggtgctgac gtaccagtgg ggggcctcgc ccttcagcta
     5101 ccgcacttcc gccgacccgg ccgaccccaa tggctggtcc gcgccgcggc ccctgttcac
     5161 cggcagcctg cccgactccc ggaccggtcc gatcgaccag acgttgatcg gcgacgacca
     5221 gaacatgtac ctcttcttcg ccggtgacaa cggcaagatc taccgggcgt ccatgccgat
     5281 cgggaacttc cccggcaact tcggctcgtc ctacacgacg gtcatgagcg acacggtcaa
     5341 gaacctcttc gaggcacccc aggtctacaa ggtccagggc cagaaccagt acctgatgat
     5401 cgtcgaggcg cggggcgcca acgagaaccg ctacttccgc tccttcacgg cgaccagcct
     5461 gaacggtacg tggaccccgc aggccgccac cgagtccaac cccttcgcgg gcaaggccaa
     5521 cagcggcgcg acctggacca acgacatcag ccacggtgac ctgatccgct ccaacccgga
     5581 ccagaccatg accgtcgacc cgtgccacct ccagctgctc taccagggca aggaccccaa
     5641 gtcggacgcc ccctacgacg cgctgccgta ccggccgggt gtgctgaccc tgaagcgctg
     5701 agcccttcca cagacagttg cccgtcagtt atccgcaagg agcacgcctt ccccgtgaac
     5761 atctctccct acacccgcac gggctcccgg cggcgcggtc tgcaccgccg ccgccggggc
     5821 gccatcgccc tgctgctcgc ggtgcccgcc gcggccgtgc cgtacctgct gctcacgcag
     5881 gacgactccc aggccgcgaa ggcccggccg tccgcggcag caccgtacaa gtggaagaac
     5941 gcgcaggtcg tcggcggcgg ttacgtctcc ggcctcgtct tcaaccagcg tgagcggggt
     6001 ctgctgtacg cccgcaccga catgggcggc gcgtaccgct gggacgtcgg cgccgagaag
     6061 tggatcccgc tcaccgactg gctcggcgag aaggactgga acctgctcgg catcgactcc
     6121 ctcgccaccg accccgtcga ccccgaccgg ctctacctcg gcgcgggcac gtacaccaac
     6181 gactgggcgg gcaacggcgc gatcctccgc tccaccgacc gcggccgcac cttcaagcgc
     6241 accgagctgc ctttcaagct cggcggcaac gaggacggcc gcggcgcagg cgaacgcctc
     6301 gtcgtcgacc cggcggacca ctcgaacctg ctcctcggct cccggaagaa cggcctgtgg
     6361 cggtccaccg actacggcgc gacctggcgt caggtcgagt ccttcccggt caagggcggg
     6421 gcgggcagcg gtgccggcat ctcgttcgtg acatacgggc cgaagggcag cgacaccgtg
     6481 tacgccggtg tcgccgacaa gtccacgtcc ctctaccggt cgaccgacag cggtgccaca
     6541 tggcgggcgg tcgccgggca gccgaccggc cagctgccac agcacggtgt cgtcacgggc
     6601 gacggcacgc tgtatgtgac gtacaccgac aacctcgggc ccaacggcgt caccggcggc
     6661 tcggtccgga agtacacgcc gagcggcggg ggctggaagg acgtgtcccc ctcgcagggc
     6721 tcgtacggct tctccgggct cgcggtcgat ccgcgcaagc cgtccacggt gatggtcacg
     6781 acgctgggcc gctggtaccc cgaggacgag atctaccgca ccacggacgg cggttcgacc
     6841 tggaaagccc tcgccgacaa gtcggtacgg gacgcctccg gcgcgccgta cgtcggcacc
     6901 cacaccggtc actggatgac ggccctcgcc atcgatccgt tcgactccgg gcacgtgctg
     6961 tacggcaccg gcaacgggat ctggcggagc gaggacgccg acgccgggac gagccactgg
     7021 accatagggg ccaagggact tgaggagacg gcgatcctcg acgccatcgc cccgcccggt
     7081 ggcgcgaccg tcctgacctc catgggtgac cagggcggat tccgccacac cgacctgacg
     7141 cgggtgccgc ccggacggat gaggaacccg ctgatgagca acagcaccga catcgactac
     7201 gccgcgtcga aaccgtcggt gatggcgcgg gtcggcacgg gcggcaagca ggacggcgcc
     7261 tactccaccg acggcggcgt cacctggcgg ggcttcgccg ccgaaccggt ggccgacgcc
     7321 cacagcggcc gtatcgccct cgcggcggac ggctccacgc tggtgtggac ccagtccggg
     7381 cagtccccgt accgctcgac ggacaaggga gcgacctggt cgaaggtgcg ggggctcggc
     7441 acgggggcag aggtcgtcgc cgaccgctcc tccgcccgca ccttctactc cctgaccggc
     7501 ggcaccctct acgccagcac cgacggcggc gcgaccttca ccgcccgcgc gaccggcctg
     7561 cccgccgacg gccgcctcaa ggccctcccg ggccgggcag gcgaactgtg gatcgcgggc
     7621 ggcggcaagg gcctgctcca ctccacggac gggggcggca cgttcacccg gctcacctcg
     7681 gtgacgtccg cctcggcggt cggcttcggc aaggccgcgc cgcgcgcctc gtaccagacg
     7741 ctgtacctga tcggcacggt caaggacgtc accggcgtct tccgctccac cgacaagggc
     7801 gccacctgga cccgcgtcaa tgacaacgcc caccagtggg gcgccatcgg cagtcagggc
     7861 gtcgtcaccg gcgatcccga cacctatggc cgcgtctaca tcggcaccaa cggccgcggc
     7921 ctccagtacg gcgacccgtc ctgatccccg tgcgtcaccc gtgacagcgg gccgccctcc
     7981 tgaccgtgat gtcgcttcgg tcaggagggc ggcccgcggc gtaaccggcc cgttgggccg
     8041 cgagggtggg cgggggagga ggccctgagc ccgtaaccgt cccgttcggg gcgtgttggc
     8101 cttccatacg ccccggaacc gctgccgagg cagctaattg agcagttgcg tgtgcgccag
     8161 ttcgctgtag agggcgtcgc gcttgatgag ttcgccgtgc gtgccgatcg ctcgtacgca
     8221 tccggcctcc atgacgatga tccggtcggc cgtcgtgacg gtggagagcc ggtgggcgat
     8281 caccatgacg gtggtgctgc gggcggcatc ggtgatcatg tcgcgcaatg ccgcctcgtt
     8341 ggccgcgtcg agttgtgagg tgacctcgtc catcagcagc agtctcgggc ggcgcagcag
     8401 agcgcgggcg atcgccaccc gctgtcgctc gcccccggag aggcggctgc cacggtggcc
     8461 gacgtgggtg tccagcccgt gggggaggcg gtccgtcaag gtgtccagcc gcgccatacg
     8521 cagcacctgg gcgagttctt cgccggaagg gtcgctggca ccgagcgtca ggttgtcccg
     8581 cagtgtgccg gcgaggacgg gagtgtcctg ttcgacgtag ccgatggatg cgcggagctg
     8641 gctcaggggc cactgccgtg tgtccttgcc gcccacgagg atggacccgg catcaggttc
     8701 gtagaagcgc tcgatcagag agaagacggt ggtcttgccc gcgccggagg ggcccacgat
     8761 cgccgtcaga ccgcgcccgg gcacggtgaa ggagacctcg tggtgcaccc tgggcagccc
     8821 gggccggtaa gcgaaacgca cttgacggaa agtcacgtcg agtggtgacc ggccgtcctc
     8881 ggcggccatg gcgggggagc cgcccctcgc tgtcgctccc cgcgtgtgct cggtcgtgtg
     8941 ctcgggtttc acctgttcgg cctcgagcgt ctcaatgtgc tcgatgcgga cagcggccgc
     9001 agatccgatc tggaactggc tcactccttc gacgagttga ccgatgcgag gggcgagggc
     9061 gaagagatac aacagaaagg cgaccagggt ggagacgctg atcgtgccgg cggtgacccg
     9121 ggcgcctccc accccgagca cgacgaggaa gcacacctga acgaccaccg ccgacgccgt
     9181 ggccgacacc gcctcccacg ccgcggcccg cgtacctctg cggcgggcgt gttcggccgc
     9241 acggcgcagc gcttgggtct cccagtgctc ggcgcccgat gccttgaccg tgcgaaaggc
     9301 ccccaggacg cgctccaggg cgcccccgat gtggcccacc gcatcctgca cctgccgggt
     9361 cgcgcggccg atgcgcggag ccacgaccgc gacgatgaca ccgacgaacg cgatcacgcc
     9421 gagagtgacg cagagcagga cggcgtcgag gaagcccatg atgacgacgg tcgcggcggt
     9481 gaccagcgtg ccggtgacgg cggcggacac cgcctggggc gcggtctggc gcagcaacgt
     9541 cgtatcggag gtgacgcggg cgatcaggtc gcccggttcg gtgcgctcca ccacgggcac
     9601 ccgcaggcgc agcagccgct cggtcagtcg gcagcgggca gcgcagacca tggactcggc
     9661 cgaccgttgc agcacgtagt gacccagccc cgcgagtacc gcgccggtga ccaccagcag
     9721 gctgagcatg aggatggggc cggtggtcgg ccggccctgg ctcatgtcgt ccatcacccg
     9781 tttggccgcc aagggctggg ccaggcccat gacgctgccg acgagcccga gcaggacacc
     9841 cgcggccatg cgccaacgct gtgggctcag atgggtcatg agcgctcgtt gggaggccca
     9901 ggcgcgctcg ggacccgtgt cctcatcagg ttcgtgggag ccgtcggcgg ggccggtgag
     9961 ggggcggggg ccctcgatgc cgggggccgt ggtcatcggc tcactccacg gtgaagaagc
    10021 gttggaagta tgtgggtgag gcgtcttctc cgacgaggac accctcggct tccacccagg
    10081 cgtgggcggc gaagggcggt cggctgcgta cgcccacgca ccaggtgggc cagtggccgt
    10141 accaccggca gagcagcacg gtggccaggg atctcgggag gcagcccttc tgcccgcccg
    10201 cggacaggct tacggcgagt accgtctcgc gggccttctc cgcctcggag agggtggcgg
    10261 gccgggcgcc gcgccgcagc ctggccagga tggtgcggat gcggcccggt ggcatggtgg
    10321 ccagcacatg ggcacagccc acggctgccc gggcggcgaa gcggcggccc accggtacgg
    10381 aacacggatc gtaggggaga gcttccgggg tcgtcatgcg tgcctcttcg gtcggaggag
    10441 ggcggggcgc gggggagcgc tatgtggtga ggagtccggc ggagcgcagc tcaccgacga
    10501 tggcgtcgac gtccttggct gcttcgtcgg cgccgatgtc gtcgtactgc gtggtcagcg
    10561 cctcgacggc ccgctccgcg ccgcgggcac gaccgtccag cagggtccgc aggacaaggg
    10621 ccgccgtcgg gttgagggtc cagtactcgg cgctcttctg atcgagcagc gccacgccgt
    10681 attcggtctc ggtcatcagg acgccgggcc tcaacgcgtg caccaagatc attcctttcg
    10741 gtcggcgagg ggctgggcgg ggacggcgtt cccatggcgc gggggcgtca tttcgcggga
    10801 gcgcagccag acttcgcagg cgattgtcgg gtgcagcagg tagctctccg tctccgcggc
    10861 gagagagcgg cggcaccact cacgcaggat gttcgcgtcg atcaggccga gctgggccag
    10921 ccgcgagtcg tcgcacagtg ccagcagtcg ccgacggtgc tcgcgcaggc cgacctcctc
    10981 ctcgaacgtg gcgttcgcct tggtgtcgcg cgtccggctg gtctccggca cgacaccgcg
    11041 catggcctcg acgatcaggg gtttataccg ccagggggtg atccgttcct gtggccgcac
    11101 ggcgaggcag gtctcgatga cgcgagtgtc gtagtagggg gcggcgacgg cgatgcccag
    11161 gggcgcggcc atctggccga tgtgccgggt ccactgggag atgccgtcca tcgcgaccag
    11221 ttctcggtgc tcaccgtgcc ccctgccccg gggttcgatg ccggccaggg cggcgcctat
    11281 ctgttcgcgg gcggccgtga tggcgtcggg tgtggcccag ggtgccatcc ggggtggtgt
    11341 ggaccagtcg agcagcggtg tgttcgtgcc gggaggcggc ccggtcaggt cgcgggccac
    11401 gcggccgacc cagcttcggt aggagcgccg gtccaggagt tggcgcagcg ttgcccgccg
    11461 gggccactgg tacttggcgg cgtatccgcg gatgttgcgc agtgcggtcg agggatgggt
    11521 cagtaacagg gaatgcagcc gggcgggcgt gccggcgagg agttcatcgc cgcccagtcc
    11581 ggtcatgtgc aggtgggatc cgcgggccgc ggccatttcc acgatgccca tccgacggtt
    11641 gcggtcgacg gtgatgatgc tgggcgtgtc caggatgtcg tggagggtgt cgattccgtc
    11701 gaaggtcatg gccgtgtcct cggccggtac gacgtggtgc tcgatgccct ggagttcctg
    11761 gacggtgcgg cgggcccagt gcacgtcgtc gccggattcg tcgtggagcg cggctgtgta
    11821 tgcgacgacc ttggtgtcgc cgcgggccgc cgtacagcac agggcggtgg agtccagtcc
    11881 gcccagatcc gccgtcacca gctcgcgccc gcgggtgcgt acaccgaccg cttcagtgag
    11941 cgcctctctc agctgccggg cgccctcggc gagggggagg accgggtcgg gcggcgacca
    12001 ccaccgcctc atggtggtcc ggccgtcggc gtcgagggtc aggcagtggc ctgcgggtac
    12061 ggcccgcagg ccccgccaca gcgggggcgc cgacagcggg tacggcgctc ccgaggtgag
    12121 cagttcgagg gcgatccggc gttcgtcgag atcagcgtcg atcagttcgg cgagcacgtc
    12181 ggcccgatcc gacgccacgc tgacggggcc gcatgccgtg gtttcggtgt ggaatacgcg
    12241 ccgtaggttc acgatgccgc cccgtacgtg cacccggccg ccgacgctgg ccaccagatg
    12301 gaagctgccg ggccggcgtg cggcgcggtc cagggccgac agcgaggcgg gaccggtggc
    12361 cgcggcggct tgttcgagat agtgctcagt gacggcgtgc tccccgatca ccgcgatacg
    12421 ggtcccgcca caccgcccca gcacggcggc gggctcctcc cagcggccca ccagccacgg
    12481 ccgtccagag gcatggagca gactccgggt ggcgtagcgg tgcgccctgg cggcgaaggg
    12541 cgcggccgcg gcggtgtcgg gcaacgcgat gaaccaggcg ggcgcggtct ggagggagag
    12601 atacgtagcc atgagcaacg gccttcggtc ggcggcgagg tgatgcccgg ggcacaggat
    12661 cgggtggcgg ctggacgcca ccacccgata gtcggcctgt tcaagggccg gcgcatacgt
    12721 tctgcgactc atgaccgctc agcggctggg gccgcccccg atcagaggaa ctgcttgccg
    12781 ccgaggacgt ccttgggacc ggtgttcttg atcccggtca ccttgcggaa gcttccggcc
    12841 ttggtgagag tgggacgctc gtacgtcata atcgttctcc ctttttgagg acgatgcgca
    12901 cagaaaatat gtgcggcgaa ttcaattaga cctcgtctcg aatatcgaga gcggtcaaat
    12961 ccgcaggacc aacgtatgta cgaaaagggc aacatcacaa cacctgctcc gaaccgcgag
    13021 gcggacgatg ggtgcaagag gggcgcgcgt ggggcgcagt ccgtgaggcc gcgaaagcgg
    13081 aagaaggcgc cccctgcatg aggccctcca aggtgcggaa atcgccgcaa aaggggcgcc
    13141 cttccgccct cgcgaggcgc gtttggcgtg cagccctgcg gggctgttct gctgcgcatt
    13201 gggcacggcg cgcactttca tggccgtaca gcaaatttag aacagcacta aattgtccgg
    13261 cataaaaagc gctgcttggg tcgctcctga gtggcatccc ttcgccgcct tcgtggtcag
    13321 ggcgccttgg ccgtcaaatt gaaacgtgga tgcgtgtgcg gaggggctgt ggctgaacgg
    13381 gcggcaccgt tcgagggcgc ctatcgtgag tcgcgggggt atcgctggag gtggtcatgc
    13441 gaatacgctg cgtgattggc agtgccatgg cgcttgccct ggtaggagtg ggagcgcccg
    13501 ctggggccgc ggagggcgac ggccccgacc tgtcccggtt ctacgaccag aagttcgcgt
    13561 gggcgagctg caaggtgttg gcgggcgtcc tcgaattccc cggcgacatg cagtgcggca
    13621 aggtcaccgt tcccctggac tatgcggcgc cggagaaggg cacgatcgac ctcttcctca
    13681 acaggattcc ggcctccggc aagaagcgcg gctctctctt cctcaacttc ggcggccccg
    13741 gttccgcggg cgtccccggg gtcgcgggcc gggcgaagga gttcggggac ctcaccaagt
    13801 cgtacgacgt ggtcggcttt gacccgcgtg gtgtcggctt cagctcgccc gccacctgcg
    13861 gtgacggcag cgaccagccc tcgtctgccc tggacggtga cgagagcacc gcagccgacg
    13921 tcatggacaa gttcaccaag gcatatgagg agtgcaagaa gcactccggg ccggtgttgc
    13981 agcacatggg gaccatcaac gtgtcgcgcg acctggacgt gatgcgccac aacctcggcg
    14041 acaagaagct caacttcctg ggcttctcgt acggaacgcg gctcggcgcc gtctacaccg
    14101 cccagttccc caagaacacg ggccggctcg tgctcgacgg agtggacacg ctcaccgaac
    14161 cgctgaccga gtcatcgctc gtgggcgctc agggccagca gaccgcgctg gacaacttcg
    14221 tgacctggtg tgcgcgcaac gagggctgcc cgctcggcgc gaacccgcga gacgccaagg
    14281 agaacatcgc caaactggtg accacactca aggcgaagcc cgtggtggcc ggcaacgggc
    14341 aggagttcac cggcgacgac ctggtccact ccctggggga ggcgctctac ggcaggggca
    14401 actggcctta cctgtcgcag gcgctcacct cactgatcac cgacgacgac cccaggtcgc
    14461 tgcttcggat cagcggttct ttgctgccgc ctgaccccga ccccgatacc ggccccaccg
    14521 gctccgggga ggagggtccc ggcggcatct ctcccgtacg cgtcatgctg cgcacggcgc
    14581 aggaagagga gccggtcaag ccgccgccgg acgacaactc cggcatcgcg ctgacggctg
    14641 tcaactgcgc ggacgacccg gaccgcctca cggtcgccga ctttgagaac gatgccaagt
    14701 tcgagcggat ggcgcgcgac tacgccaagg cttcgccgat cttcggcccc tccgccctgc
    14761 tccaggtccg gatgtgcgcg ggcttccccg cgggcaccga cttcgtccgt gggatcaaga
    14821 acgtgcacac gccgaagttt ctgctggtgg ggacgcgggg agaccctgcc acgccgtacc
    14881 gctggacggt cgagaccgcc aagcggctcg gagactcggc ggtcgtcctc gacaacaagg
    14941 gcgacggaca tggcgcgtac ttctcctcga agtgcgtgaa gcagaaggtc gacgatttcc
    15001 tgctgtacgg ctcgcaggtc aagagcggct catcctgcgg ctcagacaag tgatccctcg
    15061 tggtgccccg tcaagcgccg ggggtgagag aaggcggtcc gggaggttac cgacgggagg
    15121 cggtgcggga catcacggct tccgggtcgc tttccatgct caccaagcga atggggggat
    15181 gctgatgccg tcgggacact gttgacgcgt ggatgcggcg gcggccgccg ccggtcacgt
    15241 tgaggaggac gcgcgcgtcg cgggggatgc gccggacagc gacagcctgg cgtagacagg
    15301 ccagagccac ggctgccggg cgttcgatat cgacgccctc cagctcctcg aaagctgctg
    15361 cggcctcatc tgccgcccgg cgaccggctg tgagaacgtc gccgcgggtt cgcgtcagga
    15421 tgtcccggat gccgccgtgc gcccagtacg gcggggcgga gttcaccagt tccggcgcat
    15481 agacctcggt gggcggaggt ggcgcggaaa aggagtgcgg ggtcttgtgg ttccacaggt
    15541 cgtggatggg ggcgaacgcg gtgttctggc acaggatgag ccggggcagg gcggtggtgg
    15601 ccgtggttgc tgaccgtgcg atgcgggtgg cggcttcgta ggtggcgatg gccccggcgc
    15661 cgcttccgac tgcttggacg tagtagtcgg gaagccttcc cattgcctcg tacgccgcca
    15721 gtgtcacggt ggcgaggccg tcgcggcggc cgacgttgcg cacgccgccc tctgcgaaga
    15781 actccggaga caactcgatg atccttttgc tgtaggcgat ggcctggttg tagtcggccc
    15841 ccttcagggc gatgacgcgg gcgcaactcc cggtcccggg gaggccgttc agcgcgggga
    15901 gggcgctttc ggggaccacg agaacgcacg ggaaggggaa gttccgacag gcggagagaa
    15961 acgccgcagc cgtgttgccc gcggacgcga cgaccatggt cccggctccc tccgggaccc
    16021 gagccagaac gctgtacgcc tccagctcct tgaaagtccc gctctccata cggcagttgc
    16081 gttcaggcca gaagccgctg aaggagatcc acagatcgct caggccgacg gccatggcga
    16141 gccgttcgct gcgaaacaca tgaggcgcac tcgagccggg cacctcccgg cacgccggca
    16201 accagaagcc gtaacggaag attcccgaag ccccgggctc aggcttgaac cgcagggaac
    16261 cgtagtcggt ccgcaagagg gagccatccg cgcacgcagg acattccagg accgtgccgt
    16321 cgtcgacgag cctcagcccg cagcccgtac acaccagttg gtaagacccg tcacgggcgc
    16381 atggagcgcc gctggtcatc gggcgctccg ccgatcattc gtggacgggg cgggggaggc
    16441 gatatcgatg aggtgcgccg ggtagatccg tcggacgctg gtgcccagcc ggctgatgtc
    16501 cgctccatac acgtggaggg agatggccgg cccgggacca ggattacgga ccacgtgaat
    16561 atcgcctggc gggacgaagc cgttgacgtc tccgacgctg ttgaccagcc gctccgtggc
    16621 aacgagtctc tcccctgggc cggtcgaggc gatgcggtac cgctcctcga cctccctgcc
    16681 ttcatatacg cccgtcacgc accaggaaac atggtcgtgg acgggggtct cctgtcctgg
    16741 aagccacacg agcgcgacca cagagaagag cccgcctggc tcggcgtgca gcaagtgctg
    16801 ccggtatcca tcggccctcc cctctcgctg gtgcgccgca agcaggcccg gggcggcgag
    16861 aaaggggcgt agccgttcgg acgttctggc cactcgctgt gccgcagtga acgacgatct
    16921 caccgtctcg cgcaccactg ccacaagatc tgccagtcgc gcgtttccct caaccgcatc
    16981 agggcgggac ggcacaccga ccacgaagcc actcctcagt cacgtcaggc ctcggccgga
    17041 gagacaagcc cgagccagat cgtgctccac gctatccacg cagatgacac agcgcctttg
    17101 ttgctcggcc agctgggggc ctggctgcgc tccggcagca cagcagagcg cagccgggtc
    17161 gtcctctacg gcccgcgggt gggagccgga ccgggaccga cccgacgggg caccagcggc
    17221 acgatcgacg gcaggcgagc cctatgcggg ccgaaagggt gaccgccgta ccgcgggccg
    17281 ggtcggggag cggattggag agtccgaagc cggatgatgg cgaggcttgt agggctgtga
    17341 cggttcggcg tggtggcccc gggcgctggc ggtcaccggc cgccgacgcc gtcggtgcgt
    17401 tgaggaggat gctcgatgag tttgtcccgc aagcagctgc tgaagatcat gggcgggacc
    17461 gctgtcgcgg ccggtatgcc gttgggcgct gccgaggctt cggcgtccca ggctccgaca
    17521 cggaagcgag atgtctgcat cgtcggtggt ggggcgtccg gcacctacac cgccatgcgg
    17581 ctgcgtcagc tcggcaagag cgtgctcctg gtcgaacgtt ccgacaggct cggtgggcac
    17641 accgagaccc accgtgatcc cgtcaccggc gacaccaccg agatcggcgt ggtcctctgg
    17701 cgcgatctgc ccgccgtccg cggctacttc aaacggctcg gtgtccccgt cgaggtcttc
    17761 tccggccacg agtcgaagcc tccgaagtac gccgacttcc ggaccggggc tccggtcaac
    17821 gccccggcgt ccccacctga tctgatgacg tcctacttca aggtcctcaa gaagtatccg
    17881 tacctcgcga ccggatacga cctgcccgac ccggtccccg ccgagctgta catgccgttc
    17941 gcgaagttcg ccgccaaaca cggcctggaa gctctcgtcc ccctccttgt acgggtcatg
    18001 atgggcttcg gtgacctgct caccctgccc acgctctacg tcatgaagag cttcgacatc
    18061 gacatggtgt cccgcctcct caacggcggc tcctttctca ccacgaagag cgggaacaac
    18121 agcgagctgt acgaaaaggc ggccacgcac ctggacgatg acgtcctgct caacgccgaa
    18181 ctcatccggg tcaaccggtc ccgtgacctc gtcaccatcc gggtcggcac gccgcagggg
    18241 ctccagacga ttctcgccaa aaagatcgtc ttcaccgcac cgccgacgca gcgcaacctg
    18301 gccccattcg acctcgaccg cactgaacgg actctgttca gccgcttccg tccgcacttc
    18361 tactacaccg ggctcgtacg tcttcccggc gttcccgaca ccatgacggt ccagaacctc
    18421 ggttccacgc cgccgttcca catgcccgct ctgcctgcgc tttaccacat ccagtcgagc
    18481 ggtgtgcccg gtctgcacca tgtgaaatac ggcagtacgg tcccgctcac ctataggcag
    18541 gtgcgggcga atatccacgc cgacatcaaa cggctcgtag ccgccgggac gattccggcg
    18601 acgaccgtga aactctccac cctcaagagc cacagcccgt acggaatgag cgtcagcgcc
    18661 gacgacatcg ccaacgggtt ctaccgcagg ctgaacgccc tccaaggccg caaccgcacc
    18721 ttctacaacg gtgccgcctt ccacgcgcac gactcgtcgc tgctgtggca gttcaccgaa
    18781 cggctcctcc ccaacctcac ctaaagggtg ttgcggagtg cggccgaggg cgaggtgccg
    18841 agcggtaccg cgaaccgcgg ctgccagcct gcctccgtca gtgccaccag ctgaaccgcc
    18901 gtcgcccgag tgcgcagcgg cagcagactg ccgatcgcag cgcggacttg ggcggcggct
    18961 gccggggtgt ccgcacccat ggcgaccgtg acatgggcgg cgggctgcgc cccgaagcgg
    19021 cccttgtacg ggcgcaaccc aggccagcgg gtgcggaacg catcgacgat cgtctggagt
    19081 cccggaacgg tgacggcgac gaagccggac tccgtcacga cctcctccaa gagcagatcg
    19141 gctgccggaa aactcgcggc cagggaccgc acgcccttct cgtcccgatc tgtcagcgcc
    19201 gattccggca cgaacgggta gaggagcgag acgtgcgccg gcacgccacg acgcaccagg
    19261 gccgggtcga tacgccatgc cgcatcgagg agcggggcgg catcgggcaa gacaatgacg
    19321 acggcagtgg tccctggctc tggcacgccg tcatcatcgc aggccagtcc gctgctgcgc
    19381 gcggatctgg tcgtggccgt ccctacagcg agcgccgccg cacggagcgt aaggggtccg
    19441 gacctgacct tggcccggac ccctcagtgc tactccccgc taggtcgctc ggcccgccgg
    19501 gtggaagttg atgcgttccc tgacgacggg gaagccggcc ctggcgaagt tcgcggccat
    19561 ggggaagttg gcctggtccg tcgctccgcc gatgaactcc gcgccctgct cgacgaggag
    19621 gtgggtgcac tccgcgagga ggtcgtaggc gtagccgcga ccgcgctgtt ccgggacgac
    19681 cccgatgaag ccgatggtcg ggccggaggg gttgtgggcc gggatgtgga tgccggccag
    19741 gtcgccctcc ggcgtgtgcg cggtctgcca ccactcccgt ggggaggggc accagtggaa
    19801 gaagtcgagt tcctcctggg cggcctggtc gagaccgccc tccccgatag ccctgagcgc
    19861 gtgggcgtcc agggtgacgg agtggatgcg gcgcaacgcg tcgaagaaca cggtgtcgtc
    19921 gggttcggcg ctgaagcgca ggcgtccggg ccgttcgggc agccctcgct ccggggtcca
    19981 gcggtacagg aagcgttcca ccaggagttc gtaccctgcg gctcgtgcgg cggcgaagcg
    20041 tgactcggcg ccggcacgca ggtcggtctc ttcccgccag ccgcctggca ggttgatctc
    20101 gagttcgacc tgccagggag cggagcgcag gagttcggca cctgcctcct cctcgccctc
    20161 ggccacgtcg aaccagttga tgttgacggg ctccgagtcg tcggggccgc cccaccaggc
    20221 gccgcgtgcg acgacctcgc cgtcgcgcag ggcgacgcgc ttccagtcgg ggcggaactg
    20281 ggtacgccga tgggcttcac gggcgcccaa gggatcgggg agtacgtcga agagatgagc
    20341 gtcgctcgcg gagagcgcgt ggatgaccac ggcggtcatg gattcctccg ggatacaggc
    20401 tgcttggagc gctcccggtc agaacctacg aaccacgccg ggacagcgga aagagggagc
    20461 gctggaaagg tgtgaaccgc acggcactcg cctccttcca tccgtctcag ggcgtggagc
    20521 cacacattaa gtggcccact gcgcgcccgt ccaccaattt cggatcgagg cgcgggtggc
    20581 cgggcgaaac ggcaccgtga acgtgggtgt tggtacggcg gtaccggcca gacgagggat
    20641 tgacgccggt gatcgtctgc ggcggggtgt cggcgtggtc ctcggggtta gacgtatgac
    20701 agtcatacga aagctgagga gttccgatga gccgcccctt tcaccaggac ccggtgaccc
    20761 gagaggacgg acctgcccgg ccgccgctgt gccgtcaggc ccccgcgagt gagcgtcacg
    20821 agagcccggt gagcacagcg cagtgaccat tgccgatgtg gtgttcgcgt ggctgggagt
    20881 gggggcgttg gtcgccgcgg tgctgccccg cgtagtggcg gggcggccgg tgtcgttgcc
    20941 ggtggtgttc ctggtgagcg gcgtcgtcgt gtacgcgctt ccgctgccgt tgccggtggt
    21001 cgacccggtg gagcaccggc tcgtgacgga acacgtcacc gaggtctgcg tcatcatcgc
    21061 cctgatgggc gccggactgg cgctcaaccg gccggtgggc cggcgcctgt gggcctcgac
    21121 ctggcgtctg ctgggcatca cgatgctgct gacggtcgtg gcgaccgccg tggtggcgtg
    21181 gtggttgctg gagtggccgc cggccgccgc gttgctgctc gcggcggtcc tcgcgccgac
    21241 ggatcctgtg ctcgcgtcgg aggtgcgggt gggggagccc accgaggaga agcacgacga
    21301 ggacgaggtg cggttcgccc tcaccagcga ggcgggcctc aacgacggcc tggccttccc
    21361 cctcacgtac gcggcgatcg cgctggccgc cgccgcgggc agcggctggt cggccgagtg
    21421 gatcggcacg tgggcggcgc atgacgtcgc gtacaagagc gtggtcggtg tgctgggcgg
    21481 actgctgatc ggcaagctgc tgggctggct gttcttccgg acccgctcct cggtgctgcg
    21541 gctggccgat caccgggaag gtttcgtcgc gttgggcgcc accttcctgg cgtacggggt
    21601 caccgaactc gccggtggct acggctttct cgccgtcttc accaccgcct gcgcggtccg
    21661 ggcggccgag cgcgcccacg gcttccacaa cgtgctgcac gacttcgtgg aacaggtcga
    21721 gcgactgctg accgcggtgc tgctgttcct gctgggcgcg ttcatcgcgc tgggcggtct
    21781 ggcaccgctg acctggcggg gcgccgcgac cggtctgctg cttctgctgg tcgtccggcc
    21841 gctggccggg tgggccgggc tgctgggagg ccgcttgcgg ggctgggagc gctgggtcgt
    21901 ggcgggctac gggatccgcg gtatcggctc gctgtactac ctcgcctacg cgctcgggca
    21961 gcaggacttc gcggtagccg agcgcgagct gtgggcggtg gtgaccttca cggtgctggt
    22021 atcggtcgtg ctgcacggcg tcacggccgg gccagtggtg tcccgtctgg accggcggcg
    22081 gcccgcaccg cccccagaac cgggggagaa gcgcggggac gagacagcgc gagtggagga
    22141 agccccacgt ccggccgtgg gccctgcggc gggcgatggc tgagccacgg gccgatcagc
    22201 cgaggagcgc cgaacacggg ttcgcctttg cgcccttcgg gtgttcctct gagattccct
    22261 gccgcagccc cggatctttc cacttggatg tccgaggcgg cgtgggcacc ttgggcggcg
    22321 cgagcacctt gggcacgcgg gcaccttggg cagggggtgg cgagtgaatc ggcaggtgtg
    22381 cttcgagtac gtgtgcccgg cgctgcccgc acaaccccag gcggtctcca tactggacgc
    22441 ggcccatcac ccggtggggt gcctcgaata ccaggtctgc catgtgtgtc gcatcgggta
    22501 cgtggccaac atcgccgtcg ccactcactg gcagggccag gggctcggcc gccaggccct
    22561 gcacacggcc atggccccgt gcaggggtta cgcctggtcc acgtcccggc ag
//
