LOCUS       NZ_CP029617            22167 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 01529 chromosome, complete genome.
ACCESSION   NZ_CP029617
VERSION     NZ_CP029617.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 01529
  ORGANISM  Streptomyces sp. WAC 01529
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. May-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 202.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945545.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:27:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,297
            CDSs (total)                      :: 7,207
            Genes (coding)                    :: 7,110
            CDSs (with protein)               :: 7,110
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 33 of 97
            Pseudo Genes (incomplete)         :: 81 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7295856
            Orig. end                         :: 7318023
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029617.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22167
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="27"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22167
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22167
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12167](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12167
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            268..2073
                     /locus_tag="DMA15_RS32415"
                     /old_locus_tag="DMA15_32405"
     CDS             268..2073
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039783.3"
                     /locus_tag="DMA15_RS32415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32405"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_164551871.1"
                     /transl_table=11
                     /translation="MHWRARIGTVDGVPRGAGVLVDRARLITCAHVVDGLTEVFVTLPG
                     IAEALPAAVAWTGGWRREGDRGDLAVVELGEPLAVAPCAFAPLDLLRPREGPSAGTAEL
                     RALGFPFGHEKDGTHVTLRTSADRLLGQEWLEIDVEQAHLQRLGEGFSGAAVYDPGTHL
                     VVGIVTDAVLGGDQEGYIGRMLPLETIRGHWEGLDDFLPLDWLPDTPRRELRALFDGVR
                     LDPGTLELTVRRAFPTFRRPLPAFRSLWHAIRYVGEELTGGERLLKLLPELGAVARVPV
                     GPWLRRWMPDRYDDKAHAAITSPRSSPPTGSVVFRAQSMTRGGGIDLSVSSVVDGVPVG
                     RAGPVRVRRQQLRAKTEALLAEQIGGVHGFDWMLEFVVPERLMSEPFEEWQIREPGAAR
                     PRPMRTVPVVVRHLDRMEPLLASYLAGRRWATVRARGRTRPERVECGLPYGYEEFHDWL
                     DADEQLCALAYAATPAPEWLSAALDTGVPIMLWRRRDCGQVNHAQCAPERFLDRITAAV
                     AELDPARLPYEVMRLRKEARSPNKGDAEHCGHRLTLFWDGAENKPDPPLSAVHQAGAGD
                     GGGSGGGSGTTDSRDMEPTESAGSG"
     gene            2075..3208
                     /locus_tag="DMA15_RS32420"
                     /old_locus_tag="DMA15_32410"
     CDS             2075..3208
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014672524.1"
                     /locus_tag="DMA15_RS32420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32410"
                     /product="MoxR family ATPase"
                     /protein_id="WP_125516245.1"
                     /transl_table=11
                     /translation="MTEKTTTWQIYSGSRVPHDGIDRLPAPPPWRTFTGGPPLPIPPGD
                     CGNPHAAASYRPGEDAVRQVNAALYLRRPLLVTGAPGTGKSSLAYAVAHELGLGKVLHW
                     PITSRVTVRDGLYEYDPLTRLYAAERARDKSRRARDESRRARDESRRARDETHHPSGQG
                     GAEPAAGDDDIGDYLRLGPLGTALLPYDRPRVLLVDEIDKSDIDLPNDLLTIFEKGSYE
                     LVELARRAAPTARVMTADRTTERVEIRDGTVTCRAFPLVVMTSNGEREFPPAFLRRCVT
                     VNLKQPASRVELTAIVREHLGPVIGEPDGTLPAGARKVIDRFFERRSSGLLANDQLLNA
                     VYMCHHASFSEEPASVRELADQVMPFLSSEVTRTDDD"
     gene            3198..7583
                     /locus_tag="DMA15_RS32425"
                     /old_locus_tag="DMA15_32415"
     CDS             3198..7583
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF041121.1"
                     /locus_tag="DMA15_RS32425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32415"
                     /product="SAV_2336 N-terminal domain-related protein"
                     /protein_id="WP_125516246.1"
                     /transl_table=11
                     /translation="MTIDRLRDALEALGPPVTPLELAEMLWLAERLPPGEGAGAASSAV
                     RGDPVDLDGFGAIGGVGGVHRAGAHADTLEADRPPGRAPESDREGSGSGPGRADGAPHR
                     AALHVPRGAPRPGGDADEVLVPAPRALCHELAIQRALRPLKQRVPDRHRRTLDERATAE
                     RASRHPGLRPWAPVMVPAADRLLSLALVADTGPAMTVWRPLVRELRDAMQRTGAFRDVR
                     VWHLTDDGRRTGVRSSPGGPLRDPAALVDATGRQVTLVLSDCSGPHWWGGRAAPALHLW
                     ARRGPTAIVQPLPERLWRRTAAPAVPGRAIASRAGAPNTVLRFTPHDGRARFPPADHVP
                     VPVLELAPEWLADWAGLVTASGEHRRDTAVTYVSAAPPPRVQPLAAEGDLPLTERILRF
                     QAAASPTAADLAAHVALSVPALPVMRLIQQRVTPGSHLSDLAELLLSGLLEPVDPGRGL
                     YDFVPGARSALLETLPRPESLAVADLLTRIGEEIEARAGSATRAFRAVVQVAQGAGSLG
                     LDPAGQPFALVSEEALGLLRGRAIRVAERPVEERPVEEAGDAGEPGSSVVVDVEAPRLA
                     VDGLAPPESVRSAPGLTNIPERPQLYFVGRVREIGHLMGELRSAHAPPRLPRGVVVHGP
                     PGIGKSALAAVWAAGVAASGKRTPVWWVTADSPASIAESLALLTRALQPAGAPLLPEES
                     RVEWALRWLRAHDNWALVFDDAQNPADIQGLHLGVGGYVLITSRNASGWGSIAPPLELR
                     APELPEAVRMLQRRAGRELVGAEALCEQLDRLPLAVARAGADLADIEMSVAQYQRGLAL
                     RQLEQRARYASHMETEDAVKVRLRAAATDPGALRLILALAWYGPQPVPLDLLRPPGAEA
                     DTPSALRFLADCSLIELTTDTVILHPNVAEAAREPDDGRGGRDARHIDDARLMAARWLR
                     SALPQRADDPVDWPRWRKLLPHIDALLEHARPVDDNRHFVALLTQTAHFLVEQGESGKA
                     LTYLRRAQRDLNRLSGQEPLKTLKVTAQLARVCATCGATSEALHLYTSVLDALGSAGRD
                     VYDPEVLGMRAERAEVHQQAGDPHRAVRELDEVCLLAARALGDDDPRALRMRARLAAAR
                     EAAGEWGRAVATYEQTLADCRRVSGEDSPDTLAVRAGLASACRAAGDLPRATEVMEGAV
                     RGFRAEFGAHHPRTVMALATLAGLYAEGGRTVRAVEAYEEALGYGISALGVRHPKMLAV
                     RQLLAETLLHVGDTERALPMLEKVLSDRGAAHGEDHSETLRSADVLAAAYGVAGARGEQ
                     RALYERTLAARLRVLEPNDPETLESYDRLADVLEAGNPEITLRVRAHHGRVLVLGEDHP
                     ETLAALDRLAGAHLEEENTEQGIALFRESLRLRLATEGPVHPDTLRVLGTLARIYLSEG
                     DVSQALAVYDLAIAGTASTGEGRREAIMLMERALAQLRPVLGRRHREVRALQAQLARLR
                     "
     misc_feature    3924..3926
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(7629..8501)
                     /locus_tag="DMA15_RS32430"
                     /old_locus_tag="DMA15_32420"
     CDS             complement(7629..8501)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645342.1"
                     /locus_tag="DMA15_RS32430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32420"
                     /product="aldo/keto reductase"
                     /protein_id="WP_125516247.1"
                     /transl_table=11
                     /translation="MDVPPDDLKDRELVSKVPPIILNNGVEMPQLGFGVWQVPDDEAEA
                     TVTTALEAGYRSIDTAAVYGNEEGTGKAIAASGVAREELFVTTKLWNSDQGYDATLRAF
                     DTSLKKLGLDYVDLYLIHWPMPAKDTYVDTYKAFEKIQADGRAKSIGVSNFLPEHLERL
                     LSETSVIPVVNQIELHPHLQQRASREFHAEQGIATEAWSPLGQGKGLLEVPAIVAIARK
                     HGRTPAQVVLRWHIQLGNVVIPKSVTPSRIKENIDVFGFALDPEDMAAISALNEDRRLG
                     SDPATFNDV"
     gene            8831..8989
                     /gene="pqqA"
                     /locus_tag="DMA15_RS37750"
                     /old_locus_tag="DMA15_32425"
     CDS             8831..8989
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_093909485.1"
                     /locus_tag="DMA15_RS37750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32425"
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_125516248.1"
                     /transl_table=11
                     /translation="MPTLPMPAVEHEHSPAARAPREPVAAPADWQTPAYAVVDTALEVT
                     AYRLADR"
     gene            9000..9995
                     /locus_tag="DMA15_RS32440"
                     /old_locus_tag="DMA15_32430"
     CDS             9000..9995
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="DMA15_RS32440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32430"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_125516249.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGLPQWNCACPGCTGARAHPARRRRHAALAVRTG
                     EDRWYLVNATPDLGDQIEATPALHPGARSDVGSDIRHTPLAGVVLTDAELDHTLGLARL
                     REARDGVDVVATPPVRDAVREGLRLDALLEPYTAVRWRELPVDRGPSPAVDRGSPPTLA
                     PGPSPTVTPGLPLGEDAAGIHVVAVPVSAKRPRYAAGTGPDTDTWSVALRLTEPATGRT
                     ALYAPALAVWSDAFEAAARAADCVFVDGTFWDDDEPVRAGFTTRTATAMGHLPITGPTG
                     TAHRLTGLPGRCLYTHLNNTNPLGDPHAEQHKSLAEWGLEAATDGMVIEL"
     gene            10001..10714
                     /gene="pqqC"
                     /locus_tag="DMA15_RS32445"
                     /old_locus_tag="DMA15_32435"
     CDS             10001..10714
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669246.1"
                     /locus_tag="DMA15_RS32445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32435"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_125518150.1"
                     /sec_met_domain="TIGR02111 (E-value: 2.5e-85, bitscore:
                     284.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPAKDADPWTPDELTERLRAVSAERYHDRHPFNVRMHEGTLTRG
                     EVRRWIANRFHYQRHIPVKDALILAKFDDPALRRGWLRRIRDHDGEQDRTGGIERWLSL
                     GEAAGLPRDQLLDASRVLPGVRLAVDGYVNFCRLSPALDAVAASLTELSAPGLMRTRIA
                     AFEKHYPWIDADGLAYFRTRVGQGGRDGQEALGLVLTWARTRQEQERAVAALAFKCDVL
                     WSLLDAVDRGAGGTT"
     gene            10711..11043
                     /gene="pqqD"
                     /locus_tag="DMA15_RS32450"
                     /old_locus_tag="DMA15_32440"
     CDS             10711..11043
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003962382.1"
                     /locus_tag="DMA15_RS32450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32440"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_125516250.1"
                     /sec_met_domain="PqqD_RRE (E-value: 3.7e-15, bitscore:
                     54.2, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-06, bitscore: 27.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAQDAVRDAEPYAVPDRHAARDAVRDPWRPALTRSVLLRHDRVR
                     GVDLLVLPERVVVLRGAAGSIVARCDGEREVAGIVAELARLHPDAPVAEEVPVFLERLR
                     AEGWLR"
     aSDomain        10792..11037
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_DMA15_RS32450_PqqD_RRE.1"
                     /evalue="1.40E-17"
                     /identifier="RREFam006.1"
                     /label="DMA15_RS32450"
                     /locus_tag="DMA15_RS32450"
                     /protein_end="109"
                     /protein_start="27"
                     /score="54.2"
                     /tool="antismash"
                     /translation="PWRPALTRSVLLRHDRVRGVDLLVLPERVVVLRGAAGSIVARCDG
                     EREVAGIVAELARLHPDAPVAEEVPVFLERLRAEGWL"
     gene            11040..12167
                     /gene="pqqE"
                     /locus_tag="DMA15_RS32455"
                     /old_locus_tag="DMA15_32445"
     CDS             11040..12167
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="DMA15_RS32455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32445"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_125516251.1"
                     /sec_met_domain="PTHR43273 (E-value: 2.3e-29, bitscore:
                     101.2, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.3e-25, bitscore: 89.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.2e-06, bitscore: 25.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.3e-06, bitscore: 26.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.5e-09, bitscore:
                     36.1, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTPATLRAATPAPDPPWALLAELTHGCPLRCAYCSNPMELTDRR
                     AELSADQWADVLRQAADLGVVQTHLSGGEPLLRRDLAEIVAAADSAGIHTQLVTSGVGL
                     HRERLARLVDAGLRSVQLSVQHPDPRAAERIAGARAFTAKERAASLVRSAGLPLGLNAV
                     LHRANLDALDDFVELGLSWGADRVELANTQFYGWALRNREALLPDRAQVARARARVERW
                     RERLAGRMELVWVAPDYVDGVAKPCMGGWGAVSLTVAPDGTVLPCPAAAALLGRDAPNV
                     RDHRLDWIWRHSDAFTRYRGEAWMSDTCRGCELRTADFGGCRCQAYALTGDAARTDPAC
                     HRSPDHGLVRALVDGAAARTKEGEPPAYAYRTHAP"
     gene            12248..13324
                     /locus_tag="DMA15_RS32460"
                     /old_locus_tag="DMA15_32450"
     CDS             12248..13324
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014174700.1"
                     /locus_tag="DMA15_RS32460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32450"
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_125516252.1"
                     /transl_table=11
                     /translation="MARTLIALATAGAVTAASLALAGEPGEPGGRGEPGEPTTVSTGWT
                     IPWGTSWLPDGSAALVTERDDFRVWRVSKDGKDKQRLGTVPESQTTGGEGGLMGIAVDP
                     DWATNHHVYVMHTSTEGNRIARMTYDGTTLSGYKPLLKGIKKNKYHNGGRLAFGPDGYL
                     YATTGDAQDKALAQDRNSLSGKILRLTKDGRPAPGNPFGNHVYSMGHRNPQGIAFDARG
                     RLWEAEFGENKKDELNLIKPGGNYGWPTCEGTCDVAGMTNPKKTWAVAEASPSGIAVVD
                     SAVYLAALRGKRLWRVPINADNENVGTAKAYYVGAYGRLRSVTAVPGADALWLSTTNAD
                     GNGGQPDGSDKIFRVPIG"
     misc_feature    12287..12302
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     gene            complement(13347..15146)
                     /locus_tag="DMA15_RS32465"
                     /old_locus_tag="DMA15_32455"
     CDS             complement(13347..15146)
                     /NRPS_PKS="Domain: AMP-binding (16-468). E-value: 5.7e-91.
                     Score: 297.0. Matches aSDomain:
                     nrpspksdomains_DMA15_RS32465_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972428.1"
                     /locus_tag="DMA15_RS32465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32455"
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_164551872.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-88, bitscore:
                     296.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASAPLVGGLADAVFDHAIEDPTRIALGRKTDGRWHDVTSAAFRD
                     EVLALAKGLIAQGVRFGDRVAIMSRTRYEWTLFDFALWSIGAQVVPVYPTSSAEQVVWM
                     LHDAQVSAAMVEHEDHAMTIGSVIDRLPQLRRLWQLDADAVGELTDAGLDIDDEVVHRH
                     RRAVTPESIATIIYTSGTTGKPKGCLISHANFMFEADVMVERWEPVFRAKRGDEATTLL
                     FLPLAHVFGRMVQVAAVRGRVKMGHQPNLNAAALLPDLAAFRPSFILAVPYIFEKVFNA
                     ARRKAEKDGKAGAFDKAVECAVRYADAMEAKAFGLGPGPSAGLRMQHQLFDKLVYSKVR
                     EVMGGRVRHAMSGGSGMDRRLGLFFAGAGVTVYEGYGLTESTAAATANPPERTRYGTVG
                     QPIPGTTVHIAEDGEVWLRGGNIFQGYLNNPGATEATLRDGWLATGDLGSLDEDGYLTI
                     TGRKKEILVTSGGKSVSPAQLEERVRDHPLVAQCVVVGNDRPYIAALVTLDAEAVEHWL
                     TMRRKPMLPPGELVRDPDLETEVRRAVVAANTLVSQAESIRTFRILAHQFSEEHGLLTP
                     SLKLKRKAIEQAYSTEVEALYRS"
     aSDomain        complement(13743..15098)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS32465_AMP-binding.1"
                     /evalue="5.70E-91"
                     /label="DMA15_RS32465_AMP-binding.1"
                     /locus_tag="DMA15_RS32465"
                     /protein_end="468"
                     /protein_start="16"
                     /score="297.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HAIEDPTRIALGRKTDGRWHDVTSAAFRDEVLALAKGLIAQGVRF
                     GDRVAIMSRTRYEWTLFDFALWSIGAQVVPVYPTSSAEQVVWMLHDAQVSAAMVEHEDH
                     AMTIGSVIDRLPQLRRLWQLDADAVGELTDAGLDIDDEVVHRHRRAVTPESIATIIYTS
                     GTTGKPKGCLISHANFMFEADVMVERWEPVFRAKRGDEATTLLFLPLAHVFGRMVQVAA
                     VRGRVKMGHQPNLNAAALLPDLAAFRPSFILAVPYIFEKVFNAARRKAEKDGKAGAFDK
                     AVECAVRYADAMEAKAFGLGPGPSAGLRMQHQLFDKLVYSKVREVMGGRVRHAMSGGSG
                     MDRRLGLFFAGAGVTVYEGYGLTESTAAATANPPERTRYGTVGQPIPGTTVHIAEDGEV
                     WLRGGNIFQGYLNNPGATEATLRDGWLATGDLGSLDEDGYLTITGRKKEILVT"
     CDS_motif       complement(13842..13910)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DMA15_RS32465_0002"
                     /evalue="5.40E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="DMA15_RS32465"
                     /protein_end="435"
                     /protein_start="412"
                     /score="18.8"
                     /tool="antismash"
                     /translation="GEVWLRGGNIFQGYLNNPGATEA"
     CDS_motif       complement(14571..14630)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_DMA15_RS32465_0001"
                     /evalue="6.00E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="DMA15_RS32465"
                     /protein_end="192"
                     /protein_start="172"
                     /score="28.0"
                     /tool="antismash"
                     /translation="ATIIYTSGTTGKPKGCLISH"
     gene            complement(15304..16818)
                     /locus_tag="DMA15_RS32470"
                     /old_locus_tag="DMA15_32460"
     CDS             complement(15304..16818)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125630.1"
                     /locus_tag="DMA15_RS32470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32460"
                     /product="MFS transporter"
                     /protein_id="WP_125516254.1"
                     /transl_table=11
                     /translation="MRTWGPLTAVSLGTFMLLLDVTIVVVALPDMARALDASLADLQWV
                     IDGYALALAALLLGVGAAADVLGRRRLHVMGTALFALASLGCGLASNADVLVAARAVQG
                     LGAAAMFATTLPLLAAAYQDRERSVALGVWGAVSGASAALGPIVGGLLTAGPGWRWIFF
                     VNLPVSVASIWLTLRVVPESRGPAGRRVDWAGTAAFACIAGAGTYGVLRGGTEGWTSAA
                     TVAAFVVSVLALVCFVQVERRTAHPLLDLRLLRKPAFTGVLLGAIGYNAAAFGVIPYIS
                     IWLQTVLGMSAVRGSLVLLPLAATSFVVAAISGRLLHGVAPRLVIGVGLLLIGAGGLCM
                     AVLDAGSSWNALLPGLTIAGIGTGLVAPGLAGAALAAVPPANSGMAGGAVNTFRQLGYA
                     VGVALFGTVLTSRMADSLGHDAAHAVAGGGAPALSGTLSEHSVRAAFAAGLNGASLAAG
                     VTGLVAGVLVLVMVRTSSGQRPGVTGSAAPGAPDRGRKAAVGAGGR"
     gene            16915..17934
                     /locus_tag="DMA15_RS32475"
                     /old_locus_tag="DMA15_32465"
     CDS             16915..17934
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972426.1"
                     /locus_tag="DMA15_RS32475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32465"
                     /product="AsnC family transcriptional regulator"
                     /protein_id="WP_125516255.1"
                     /transl_table=11
                     /translation="MESTYRGPVTVESEAFDELDLKLLHALEVDGRAPFSRIAAVLGVS
                     DQTVARRFRRLRAEAGLRVVGVRDSARLGRDQWMLRLRCTPDGAEAIAAALARRPDTAW
                     VHLTSAGTEVVCMTLPRDPGDYDDLLFGKLLRTRKLIEITAHQLLHYFYGGRTGWIGKH
                     RPLTDEQVAALRPTGPPTAPGPGPAPVSIAPEDEPLVAALKADGRVTYPELQRLTGRSE
                     SAVKRRVAALLGSGALYIDTEYDTAYFGFATAAMLWVTVDPGALDEVGRAMAGHPEIAH
                     ASAVTGSANLMATVVTRDTAELYTYLSGRLGPLDGVRHIESAPLLRRFKELTYPRPLR"
     gene            complement(17969..18835)
                     /locus_tag="DMA15_RS32480"
                     /old_locus_tag="DMA15_32470"
     CDS             complement(17969..18835)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996478.1"
                     /locus_tag="DMA15_RS32480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32470"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_125516256.1"
                     /transl_table=11
                     /translation="MYDPSQLRTFLAVAQTMSFTQAARRLGLRQSTVSQHVRRLEEATG
                     RRLFTRDTHSVELTEDGEAMLGFARRILAVHEQASAFFTRTRLGGRLRFGASEDFVLTR
                     LTDILESFRHAHPDVDLELTVELSGTLHERLDAGKLDLVLAKRRPEDPRGQLVRHDELV
                     WIGSERLRLDPERPVPLIVYPPPGITRALAFEALERRGRPWRVACTSGSLNGLVAAARA
                     GLGVMAHSRGLIPPGLVRVSDRAGLPELGSVDFVLLHGERRAADQAAADALAAAILASG
                     DRLRRGA"
     misc_feature    complement(18927..18940)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            18990..20018
                     /locus_tag="DMA15_RS32485"
                     /old_locus_tag="DMA15_32475"
     CDS             18990..20018
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015293 - symporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007385916.1"
                     /locus_tag="DMA15_RS32485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32475"
                     /product="bile acid:sodium symporter family protein"
                     /protein_id="WP_206302979.1"
                     /transl_table=11
                     /translation="MPVDPYIVALLATVGVAALVPARGGAADAASGASTAAVSFLFFLY
                     GARLSTREALDGLKHWRLHLTVLACTFVVFPLLGLAAKGLVPYVLTPALYSGFLFLTLV
                     PSTIQSSIAFTSMARGNVPAAICAGSFSSLAGIVLTPLLAAALLGGTGGGFSADSVVKI
                     VVRLLVPFVAGQLLRRWVGGFLSRHKKVLGYVDRGSILLVVYTAFSEGMVQGIWHQVTP
                     LRLLALLGVEAVLLTVMLVLTWYGAKRLGFGRGDRVAIQFAGSKKSLAAGLPMASILFG
                     AHASLAVLPLMLFHQMQLMVCAVIAKRRSRDPVGFGGEEAVSGARPGGARRTAAGTAPR
                     SG"
     gene            complement(19954..21219)
                     /locus_tag="DMA15_RS32490"
                     /old_locus_tag="DMA15_32480"
     CDS             complement(19954..21219)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823828.1"
                     /locus_tag="DMA15_RS32490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_32480"
                     /product="DUF4185 domain-containing protein"
                     /protein_id="WP_240660066.1"
                     /transl_table=11
                     /translation="MSDQERHHGVGGRIWLVLLLALALAAVLLVVLPRDDRGGDGDGAS
                     TACRPRTVASWSAEEKVTGAFTRYGDDGTRTDDWTGGDGTHSVRLPDGRVLWLFSDTLL
                     GQVHAPPNTAGQPHTWRDPNAPMVRNSAVVMSRSGTLERTLPAPLFTDPAPQQWRWPVA
                     ARVEPRSLASDEKVVRVLLWNRMASQGPWIYGVPMATEVATLSLPDLRVEGIVKVSDQQ
                     RVADPEKRVLYGTATVDDDGWTYVFGGTDAQATSRPSSHAHVARVPHGRLAEAAAWEYW
                     DGEKWGEGPSRPVLGDGRRKGVGSAFTVVRDEGTYVLFTMAAGAKGLTEVTSYWSCSPT
                     GPWHGPAKGFEAPLPKDSAARQDTAAYNPQAHPALGRDGRVVLSYDVNWLDPVPASAQA
                     NINRNVALYRPRFVSLRLAEPR"
     misc_feature    complement(21446..21460)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.51"
                     /tool="antismash"
ORIGIN
        1 ggcgctcgac cccgacgcga tcgagctgga gttcggcgtc aagctcaccg tcgccgccgg
       61 ggccgtcatc gccaagacgg cgaccgaggg gcatctgacg gtccgcctca ggtggtcgcg
      121 cggtgccgcg tcggagggtg cgccggaggc gggggcggcg gtcccctcgc aggggcggca
      181 ggacgcggag catggggtgc ggcaggacgc cggaccgggc gtgcggcaac acgtacggca
      241 ggacccgcaa ggcgaataat ggcgggcatg cactggcgtg cccggattgg cacggtcgac
      301 ggcgttcccc ggggcgcggg tgtcctggtc gaccgtgcgc ggctgatcac ctgcgcccac
      361 gtcgtcgacg gactgacgga ggtcttcgtg acgctgcccg gcatcgccga ggcgctgccc
      421 gcggccgtgg cgtggaccgg cggctggcgg cgcgagggcg accgcggtga cctggccgtc
      481 gtcgaactcg gcgagccgct ggccgtggcg ccgtgcgcgt tcgccccgct cgacctgctg
      541 cgtccgcgcg aggggccgag cgcgggcacg gccgaactgc gcgccctcgg cttcccgttc
      601 gggcatgaga aggacggcac acacgtcacc ctgcgcacca gcgccgaccg gctgctcggt
      661 caggagtggc tggagatcga cgtcgagcag gcccatttgc agcgtctcgg ggaagggttc
      721 agcggcgccg cggtctacga cccgggcacg cacctcgtcg tcgggatcgt caccgacgcg
      781 gtgctcggcg gcgaccagga gggttacatc gggcggatgc tgccgctgga gaccatccgc
      841 ggccactggg aggggctgga cgacttcctg cccctcgact ggctgccgga cacgccgcgc
      901 cgcgagctgc gggccctgtt cgacggcgta cgcctcgatc ccggcaccct ggaactgacc
      961 gtccgccgcg ccttccccac cttccggcgg ccgctgcccg ccttccgctc cctctggcac
     1021 gccatccggt acgtgggcga ggaactgacc ggcggggaaa ggctgttgaa gctgctgccc
     1081 gagctgggtg cggtcgcgcg cgtacccgtc ggtccgtggt tgcggcgctg gatgcccgac
     1141 cggtacgacg acaaggcgca cgcggcgatc acctcgcccc ggtcgtcccc gcccaccggc
     1201 tcggtcgtct tccgtgccca gtcgatgacc cgcggaggcg gcatcgacct ctccgtctcc
     1261 tcggtcgtcg acggtgtacc cgtcggcagg gccgggcctg tcagggtgcg gcgccagcaa
     1321 ctgcgggcga agacggaggc gttgctcgcc gagcagatcg gcggcgttca cggcttcgac
     1381 tggatgctgg aattcgtggt gccggaacgg ctgatgagcg agcccttcga ggagtggcag
     1441 atacgcgaac cgggcgccgc gcgcccccgg cccatgcgca cggtgcccgt ggtcgtccgg
     1501 cacctggacc gcatggagcc cctgctcgcc tcctatctgg ccgggcggcg ctgggcgacc
     1561 gtccgggccc gcggccggac ccgccccgag cgcgtggagt gcggactgcc ctacggctac
     1621 gaggagttcc acgactggct cgacgccgac gaacagctgt gcgccctcgc gtacgccgcg
     1681 acgccggccc ccgagtggct ctcggcggcg ctcgacaccg gcgtacccat catgctgtgg
     1741 cggcggcgcg actgcgggca ggtgaaccac gcgcagtgcg cgcccgagag gttcctcgac
     1801 cggatcacgg ccgcggtcgc cgagctggac cccgcccggc tgccctacga ggtgatgcgg
     1861 ctgcgcaagg aggcccgttc gccgaacaag ggggacgccg agcactgcgg gcaccggctg
     1921 accctgttct gggacggcgc cgagaacaaa ccggatcccc cgctgtcggc ggtgcaccag
     1981 gcgggcgcgg gcgatggcgg cggctccggt ggcggcagtg gcaccacgga cagcagggat
     2041 atggagccca cggagagcgc ggggagtggc tgagatgacc gagaagacga ccacctggca
     2101 gatctactcg ggaagccgcg tcccgcacga cggcatcgac cggctccccg caccaccccc
     2161 ctggcgcacc ttcacgggcg gcccgcccct gcccatcccg cccggcgact gcggcaaccc
     2221 gcacgcggcc gccagctacc gccccggcga ggacgccgtg cgccaggtca acgccgcgct
     2281 ctatctgcgc aggccgctcc tggtcaccgg cgcccccggc accggcaagt cgtccctcgc
     2341 gtacgcggtg gcgcacgaac tgggcctcgg caaggtcctg cactggccga tcaccagccg
     2401 cgtcaccgtg cgcgacggcc tgtacgagta cgaccccctg acccgcctgt acgccgccga
     2461 acgggcccgc gacaagagcc gtcgcgcccg ggacgagagc cgtcgcgccc gggacgagag
     2521 ccgtcgcgcc cgggacgaga ctcatcaccc ctcgggccag ggcggcgccg agcccgccgc
     2581 gggcgacgac gacatcggcg actacctgcg cctcggcccg ctcggcaccg cgctgctgcc
     2641 gtacgaccgc ccccgcgtcc tgctcgtcga cgagatcgac aagagcgaca tcgatctgcc
     2701 caacgacctc ctcaccatct tcgagaaggg gtcgtacgaa ctcgtcgagc tggcccgccg
     2761 cgcggccccc accgccaggg tgatgacggc cgacaggacc accgaacgcg tcgagatccg
     2821 cgacggcacg gtcacctgcc gcgcctttcc gctggtcgtc atgacgagca acggcgaacg
     2881 cgagttcccg cccgcgttcc tgcggcgctg cgtgaccgtg aacctgaagc agcccgcgag
     2941 ccgcgtggag ctgaccgcga tcgtccgcga acacctcggc ccggtgatcg gcgagccgga
     3001 cggcacgctc cccgcgggcg cccgtaaagt gatcgaccgc ttcttcgagc ggcgcagcag
     3061 cgggctgctc gccaacgacc agctcctgaa cgccgtctac atgtgccatc acgcgtcctt
     3121 cagcgaagaa ccggcgagcg taagggagtt ggcggatcag gtaatgccgt tcctgagcag
     3181 cgaggtgacg cgcaccgatg acgattgacc ggctgcggga cgccctggag gcgctggggc
     3241 cgccggtcac gccgctcgaa ctggcggaga tgctgtggct ggcggagcgg ctgccgcccg
     3301 gcgagggcgc cggggcagcg agcagtgccg tccgaggtga tccggtcgac ctcgacgggt
     3361 tcggggccat cggcggggtg ggtggcgttc accgggcggg cgcccacgcg gacaccctgg
     3421 aggccgaccg accgccgggc agggcccccg aatcggacag ggaggggagc ggcagcgggc
     3481 ccggacgtgc ggacggcgcc ccgcaccgcg ccgccctgca cgtcccccgc ggcgccccgc
     3541 gcccaggcgg tgacgccgac gaagtcctcg tccccgcccc aagggccctg tgccacgaac
     3601 tcgcgatcca gcgcgccctg cgcccgctca agcagcgcgt ccccgaccgg caccgccgca
     3661 ccctcgacga gcgcgccacg gccgagcgcg cctcccgcca ccccggcctg cgcccctggg
     3721 caccggtcat ggtccccgcc gccgaccgcc tcctgagcct ggcgctggtc gccgacacgg
     3781 gccccgcgat gacggtgtgg cgccccctgg tccgtgagtt gcgggacgcg atgcagcgca
     3841 ccggcgcctt ccgcgacgta cgcgtatggc acctcaccga tgacggccgg cgcaccggcg
     3901 tccggtcctc gccaggtggg cccttacggg acccggcggc cctggtcgac gcgacgggcc
     3961 gccaggtcac gctggtcctc agcgactgct cgggcccgca ctggtggggc ggccgagccg
     4021 cgcccgccct gcacctgtgg gcgcggcgcg ggcccacggc gatcgtgcaa ccgctcccgg
     4081 aacgcctctg gcgccgcacc gccgcccccg ccgtcccggg cagggcgatc gcgtcccgcg
     4141 cgggcgcccc caacaccgtc ctgcgcttca ccccgcacga cggccgtgcc aggttccccc
     4201 cggcggacca cgtccccgtg ccggtcctcg aactggcgcc ggaatggctg gcggactggg
     4261 cgggcctggt gaccgcgtcg ggcgagcacc gccgggacac ggccgtcacc tacgtcagcg
     4321 ccgccccgcc cccgcgcgtc caacccctcg ccgccgaggg cgacttgccc ctcaccgaac
     4381 gcatcctgcg cttccaggcg gcggcctccc cgacggcagc ggacctggcc gcgcacgtcg
     4441 cgctctcggt gcccgccctg ccggtgatgc ggctgatcca gcaacgggtc acgccgggtt
     4501 cacacctcag cgacctggcc gaactcctgc tcagcggcct ccttgagccc gtcgacccgg
     4561 ggcgcggcct ctacgacttc gtgccgggcg cgaggagtgc ccttctggag accctgcccc
     4621 gccccgagtc gctcgcggtg gccgatctcc tcacccgtat cggcgaggag atcgaggcga
     4681 gggcaggctc ggcgacccgc gcgttccggg cggtcgtcca ggtggcgcag ggcgcgggca
     4741 gccttgggct cgacccggcg ggacagccgt tcgcgctggt cagcgaggag gcgctggggc
     4801 tgctgcgggg gcgggcgatc cgggtggcgg agcggccggt ggaggagcgg ccggtggagg
     4861 aggccgggga cgcgggggag ccggggtcct ccgtcgttgt ggatgtggag gcgccgcgcc
     4921 tggcggtcga cgggcttgcc ccgccggagt cggtgcggag tgcgccgggg ctgacgaaca
     4981 ttcccgagcg gccgcagctg tacttcgtcg gcagggtgcg tgaaatcggc cacctcatgg
     5041 gggaactgag gtccgctcac gcgccgcccc ggctccctcg gggggtggtg gtccatggcc
     5101 cgccgggaat cggcaagtcg gctctggccg cggtgtgggc ggcgggagtg gccgcctccg
     5161 gcaagcggac cccggtgtgg tgggtcacgg cggactcgcc cgcgtcgatc gccgaaagcc
     5221 tcgcgctcct cacgcgcgcc ttgcagcctg ccggggcacc cctcttgccg gaggagagtc
     5281 gggtcgagtg ggccctgcgg tggctgaggg cgcacgacaa ttgggccctg gtcttcgacg
     5341 acgcgcagaa ccccgccgac atccaaggtc tgcacctcgg cgtcggcgga tatgtactga
     5401 tcaccagcag gaacgcctcc ggctggggca gcatcgcccc accgttggaa cttcgcgccc
     5461 ccgaactccc cgaagcggtt cggatgttgc aacggcgggc gggcagggaa ctggtagggg
     5521 cggaggccct gtgtgagcag ctcgaccgac tgccgctggc cgtggcgcgg gcgggcgcgg
     5581 acctcgcgga catcgagatg tccgtcgccc agtaccaacg cggactggca ctgcgccagc
     5641 ttgagcagcg ggctcgttac gccagccaca tggagaccga ggacgccgtc aaggtacgtc
     5701 tgcgcgccgc cgccaccgac ccgggagcac tacggctcat cctggccctc gcctggtacg
     5761 gcccgcagcc cgtgcccctt gacctgctgc gtccccctgg cgccgaagcg gacacgccga
     5821 gtgccctgcg cttcctggcg gactgttcgc tgatcgagtt gaccaccgac acggtcatcc
     5881 tccacccgaa cgtcgccgaa gccgcgcgcg agccggacga cggccggggc ggccgcgatg
     5941 cgcggcacat cgacgacgcc cggctcatgg cggctcgctg gctcaggagc gcgctcccgc
     6001 agagggcgga cgacccggtc gactggcccc gctggcggaa actgctcccg cacatcgacg
     6061 ccctcctcga acacgcccgg cccgtcgacg acaaccgcca cttcgtggcg ctcctgacac
     6121 agacggccca cttcctggtg gagcaggggg agtccggcaa ggccctcacc tatctgcggc
     6181 gcgcgcagcg cgacctcaac aggctgtccg gccaggagcc gctgaagacg ctgaaggtga
     6241 ctgcccaact ggcgcgggtg tgcgcgacat gcggcgccac cagcgaggcg ctccacctct
     6301 acacctccgt gctggacgcc ttgggcagtg cgggcaggga cgtgtacgac cccgaagtgc
     6361 tggggatgag ggcggaacgc gcggaggtcc accagcaggc gggggacccg caccgggcgg
     6421 tacgggaact ggacgaggtg tgcctgctcg ccgcccgcgc cctgggcgac gatgacccgc
     6481 gggccttgcg gatgcgcgcc cgcctcgccg ccgcccgcga ggcggcgggc gagtgggggc
     6541 gcgccgtggc cacgtacgaa cagaccctgg ccgactgccg acgggtatcg ggtgaggact
     6601 ccccggacac cctggccgtg cgggcgggcc tggcctcggc gtgccgggcg gccggtgacc
     6661 tgccgcgggc caccgaggtg atggaggggg cggtgcgggg ctttcgagcg gagttcggcg
     6721 cgcaccaccc ccgaacggtg atggccctgg ccaccttggc cggtctgtat gcggaaggcg
     6781 gcaggacggt acgggccgtc gaggcgtacg aggaggcgct gggatacggc atctcggccc
     6841 tcggcgtgcg ccatccgaag atgctcgccg tgcggcagct gctcgccgag acactgctgc
     6901 atgtcggaga cacggaacgc gcactcccca tgttggagaa ggtgctgtcc gacaggggcg
     6961 ccgcgcatgg ggaggaccat tcggaaacgc ttcgctccgc cgatgtcctc gcggcggcct
     7021 acggggtggc aggcgcccgc ggcgagcaac gggcgctgta cgaacgcacc ttggccgccc
     7081 gcctcagagt gctggagccg aacgaccccg agaccctgga gtcgtacgac cgcctcgccg
     7141 acgtcctgga agcgggtaat ccggagatca ccctgcgcgt acgggcccac cacggccggg
     7201 tgctggtgct gggcgaggac caccccgaga cgctggccgc gctcgaccgg ctggcgggcg
     7261 cccatctgga ggaggagaac accgaacagg gcatcgcgct gttccgggag tcactacgcc
     7321 tgcggctcgc caccgagggc cccgtccacc ccgacaccct gcgcgtgctc ggaacgctgg
     7381 cccggatcta cttgagcgaa ggcgatgtct cacaggcgct cgccgtatac gacctcgcca
     7441 tcgcggggac ggcctcgacg ggggaggggc gacgggaagc catcatgttg atggagcggg
     7501 ccctggcgca gctgaggccg gtcctgggac gccgccaccg tgaagtacgg gccctgcaag
     7561 cgcagttggc ccgcctgcgc tgacctctga gggccggcgc aggcgggtcg acgtgccgcg
     7621 tcagcgcctc acacgtcgtt gaacgtcgcc gggtccgagc cgagacgccg gtcctcgttc
     7681 agggcggaga tcgccgccat gtcctcgggg tcgagcgcga agccgaacac gtcgatgttc
     7741 tccttgatcc gcgacggggt cacggacttc gggatgacga catttcccag ctggatgtgc
     7801 cagcgcagca cgacctgcgc gggcgtgcgc ccgtgcttcc gcgcgatcgc gacgatcgcc
     7861 ggaacctcca gaaggccctt gccctggccg agcggcgacc acgcctcggt ggcgatgccc
     7921 tgctcggcgt ggaactcccg cgaggcgcgc tgctggaggt gcgggtgcag ctcgatctgg
     7981 ttgacgaccg ggatcacgga cgtctcggag agcagccgct ccaggtgctc gggcaggaag
     8041 ttcgacacgc cgatggactt ggcgcgaccg tcggcctgga tcttctcgaa ggccttgtac
     8101 gtgtcgacgt aagtgtcctt ggcgggcatc ggccagtgga tcaggtacag gtccacgtag
     8161 tcgagaccca gcttcttcag cgaggtgtcg aacgcgcgca gcgtcgcgtc gtaaccctga
     8221 tcgctgttcc agagcttcgt cgtgacgaac agttcctcgc gggccacacc ggaggcggcg
     8281 atggccttgc cggtgccctc ttcgttgccg tagaccgccg ccgtgtcgat gctgcggtac
     8341 ccggcctcca gggcggtcgt cacggtcgcc tccgcctcgt cgtccggcac ctgccagaca
     8401 ccgaagccga gctggggcat ctcgacgccg ttgttcagga tgatcggggg gaccttgctc
     8461 acgagctctc gatccttcaa gtcgtcgggt ggtacgtcca tggtcaacga tcgggggtcg
     8521 cgccgcattc ctgaacggaa gcaggcattc cagaccgccg aatggccgga tttcgaagcg
     8581 acacggaggc cggaacggtc cggaccattg acggtgtccc gtcatgccgc gaccctatga
     8641 cacggcactg aacgcgggac actcatgtga acgctacaag catccccacc gctccagcac
     8701 ccccaccgcc acaaacaccc ccacccccac aagcaagcac ccccacggtc caagcatccc
     8761 cgcgtcccgg tggctcgtcc tgaaaccccc acctcttcag gaaggcagcg tcatgcccct
     8821 ccctatgccc atgcccaccc tgcccatgcc cgccgtcgag cacgagcact ccccggcggc
     8881 acgcgccccg cgcgaacccg tcgccgcacc cgccgactgg cagacccccg cgtacgccgt
     8941 cgtcgacacc gccctggaag tcaccgccta ccgcctcgcc gaccggtaga cccgccgcca
     9001 tgctgctgca ggtgctcggc accgcggcgg gcggcgggct cccccagtgg aactgcgcgt
     9061 gccccggctg taccggggca cgtgcccacc cggcacgccg ccgccggcac gccgcgctcg
     9121 ccgtccgcac gggcgaggac cgctggtacc tcgtcaacgc cacccccgac ctcggcgacc
     9181 agatcgaggc caccccggcg ctgcaccccg gcgcccgctc cgacgtcggc tccgacatac
     9241 ggcacacccc tctcgccggt gtcgtcctga ccgacgccga actcgaccac accctcggcc
     9301 tggcccggct gcgcgaggcc cgcgacggcg tcgacgtcgt cgcgaccccg cccgtgcgcg
     9361 acgcggtgcg cgaagggctg cggctcgacg ctctcctgga gccctacacg gccgttcgct
     9421 ggcgtgagct tccggtcgac cgcgggccgt ccccggccgt cgaccgcggg tcgccgccga
     9481 ccctcgcccc cgggccgtcc ccgaccgtca cccccggcct gccgctgggc gaggacgccg
     9541 cggggattca cgtcgtcgcc gtccccgtct cggccaaacg gccgcggtac gccgcgggga
     9601 ccggccccga cacggacacc tggtcggtcg cgctgcgcct gaccgaaccc gccaccggcc
     9661 ggaccgcgct ctacgccccc gccctcgccg tctggagcga cgccttcgag gcggccgcgc
     9721 gcgccgccga ctgcgtcttc gtcgacggca ccttctggga cgacgacgaa ccggtgcgcg
     9781 ccggcttcac cacccgtacc gccaccgcga tgggccacct ccccatcacc ggccccacgg
     9841 gcacggcaca ccgcctgacc gggcttcccg gccggtgtct ctacacccac ctcaacaaca
     9901 ccaacccgct cggcgacccg cacgccgagc agcacaagtc cctcgcggag tggggcctgg
     9961 aagccgccac cgacggaatg gtgatcgagc tgtgacgacc atggcacccg cgaaggacgc
    10021 ggacccctgg accccggacg aactgaccga gcggctgcgc gccgtgtcgg ccgagcgcta
    10081 ccacgaccgg caccccttca acgtacgcat gcacgaaggc accctcaccc gcggggaggt
    10141 gcgccgctgg atcgccaacc ggttccacta ccagcggcac atccccgtca aggacgccct
    10201 gatcctcgcg aagttcgacg accccgcgct ccgccgcggc tggctgcgca ggatccgcga
    10261 ccacgacggg gaacaggacc gcacgggcgg catcgaacgc tggctgagtc tcggcgaggc
    10321 cgccgggctc ccgcgcgatc aactccttga cgcctcaagg gtgttgccgg gtgtgcggct
    10381 ggccgtcgac ggctacgtca acttctgccg gctcagcccc gccctcgacg ccgtcgccgc
    10441 gtccctcacc gaactgtccg cgcccggtct gatgcgcacc aggatcgccg ccttcgagaa
    10501 gcactacccg tggatcgacg cggacggcct cgcctacttc cgcacccgcg tcgggcaggg
    10561 cggtcgcgac gggcaggagg ccctcggcct cgtcctgaca tgggcgcgca cccgccagga
    10621 gcaggaacgg gccgtcgccg ccctcgcgtt caagtgcgac gtactgtggt ccctgctcga
    10681 cgccgtcgac cgcggggccg ggggcacgac atgagcgccc aggacgccgt acgtgacgcg
    10741 gagccttacg cggtgcccga tcgtcatgcg gcgcgtgatg ccgtacgaga cccatggcgc
    10801 cccgcgctca cccgctcggt gctcctccgg cacgaccggg tacgtggcgt cgacctgctg
    10861 gtgctgcccg aacgcgtcgt cgtcctgcgg ggcgccgcgg gcagcatcgt ggcccggtgc
    10921 gacggcgagc gcgaggtcgc cggaatcgtc gcggagctgg cacgcctgca ccccgacgcg
    10981 cccgtcgccg aggaagtacc cgtgttcctg gagcggttgc gggccgaggg gtggctgcga
    11041 tgaacacccc cgccaccctc cgggccgcca ccccggcacc cgacccgccc tgggccctcc
    11101 tcgccgaact cacccacggc tgccccctgc gctgcgccta ctgctcgaac cccatggaac
    11161 tcaccgacag gcgggcggag ttgagcgccg atcagtgggc ggatgtgttg cgccaggccg
    11221 ccgacctcgg cgtcgtgcag acccatctgt ccggcgggga accgctgttg cgccgcgacc
    11281 tcgccgagat cgtcgccgcc gccgactccg cgggcattca cacgcagctc gtgaccagcg
    11341 gcgtcggcct gcaccgcgaa cgcttggcca ggctcgtcga cgcgggactg cgcagcgtcc
    11401 agctgtccgt ccagcacccc gacccgcggg ccgcggagcg catcgcgggc gcccgggcgt
    11461 tcaccgcgaa ggaacgggcg gcgtcgctgg tgcggtccgc cgggctgccg ctcggcctca
    11521 acgccgtact gcaccgcgcg aacctggacg cactcgacga cttcgtggaa ctgggcctga
    11581 gctggggcgc cgaccgcgtc gagctggcca acacccagtt ctacggctgg gcgctgcgca
    11641 atcgcgaggc cctgctgccg gaccgcgccc aggtcgcccg ggcccgtgca cgcgtcgaac
    11701 ggtggcgcga acggctggcg ggccggatgg agctggtatg ggtggcgccc gactacgtgg
    11761 acggcgtcgc gaaaccctgc atgggcgggt ggggagcggt gtcgctgacc gtcgcccccg
    11821 acggcacggt gctgccctgc ccggccgccg ccgccctcct cggccgggac gcgccgaacg
    11881 tccgggacca ccggctggac tggatctggc gtcactcgga cgccttcacc cgctaccgcg
    11941 gcgaggcctg gatgagcgac acctgccgcg gctgcgagct gcgcaccgcc gacttcgggg
    12001 gctgccgctg ccaggcgtac gccctcaccg gggacgcggc gcgcacggac cccgcctgcc
    12061 accgctcacc cgaccacggg ctggtccgcg ccctcgtcga cggtgcggcc gcccgtacga
    12121 aggagggcga gccgcccgcg tacgcctacc gcacccacgc gccgtaaccg cacccccgcc
    12181 accactcggc agagacacag agacacagag acacagagac accgagacac agagacggag
    12241 aaccggcatg gcaagaactc tcatagccct cgccaccgcg ggagctgtca ccgccgcctc
    12301 actggccctc gccggtgagc cgggcgaacc cggtggaagg ggtgaacccg gtgagcccac
    12361 caccgtgtcc accgggtgga ccatcccgtg gggcacctcg tggctgcccg acggctcggc
    12421 cgccctggtc accgagcgcg acgacttccg ggtgtggcgg gtctcgaagg acggcaagga
    12481 caagcagcgc ctcggcaccg tcccggagtc ccagaccacc gggggcgagg gcggcctgat
    12541 ggggatcgcc gtcgacccgg actgggccac caaccaccac gtgtacgtca tgcacacctc
    12601 caccgagggc aaccgcatcg ctcgcatgac gtacgacggc acgaccctgt ccggctacaa
    12661 gccgctgctc aaggggatca agaagaacaa gtaccacaac ggcggacgcc tggcgttcgg
    12721 ccccgacggc tacctctacg ccaccaccgg cgacgcccag gacaaggccc tcgcgcagga
    12781 caggaactcc ctcagcggca agatcctgcg gctgacgaag gacggcaggc ccgcacccgg
    12841 caaccccttc ggcaaccacg tctacagcat ggggcaccgc aacccgcagg gcatcgcctt
    12901 cgacgcccga ggcaggctgt gggaggccga gttcggggag aacaagaagg acgagctgaa
    12961 cctcatcaag ccgggcggga actacggctg gcccacctgt gagggcacct gtgacgtcgc
    13021 gggcatgacc aaccccaaga agacctgggc tgtcgccgag gcctccccga gcggaatcgc
    13081 ggtcgtcgac agcgcggtct acctggcggc gctcaggggc aagcgcctgt ggcgcgtacc
    13141 gatcaacgcc gacaacgaga acgtcggcac cgcgaaggcc tactacgtgg gcgcgtacgg
    13201 gcgtctgcgc tcggtcaccg ccgtccccgg cgccgacgca ctgtggctct ccaccaccaa
    13261 cgccgacggc aacgggggcc aacccgacgg ctccgacaag atcttccgcg taccgatcgg
    13321 ctgacctggg cgcccggccg gccgtgtcag gaccggtaga gcgcctcgac ctcggtcgag
    13381 taggcctgct cgatcgcctt ccgcttgagc ttcagggagg gcgtcagcaa gccgtgctcc
    13441 tcgctgaact gatgcgccag tatccggaac gtacgaatgg actcggcctg cgagacaagg
    13501 gtgttcgcgg cgacgacggc ccgccgcacc tccgtctcca ggtccgggtc ccgcaccagc
    13561 tcaccgggcg ggagcatcgg cttgcgccgc atggtcagcc agtgctccac cgcctccgcg
    13621 tccagcgtga cgagcgccgc gatgtagggg cggtcgttgc cgacgacgac gcactgcgcg
    13681 accagcggat ggtcgcgcac ccgctcctcc agctgggcgg gcgagacgct cttgccgccg
    13741 gaggtcacca ggatctcctt cttgcgcccg gtgatcgtca gatagccgtc ctcgtcgagc
    13801 gagcccagat cgccggtggc gagccacccg tcgcgcagcg tcgcttcggt ggcccccggg
    13861 ttgttgaggt acccctggaa gatgttgccg ccgcgcagcc agacctcacc gtcctccgcg
    13921 atgtgcaccg tcgtgcccgg aatcggctgg cccaccgtgc cgtagcgggt gcgctcgggc
    13981 gggttggcgg tcgcggccgc cgtcgactcc gtcagcccgt acccctcgta gaccgtcacg
    14041 cccgcgcccg cgaagaacag gccgagccgc cggtccatgc ccgaaccgcc cgacatcgcg
    14101 tgccgcaccc ggccgcccat cacctcgcgc accttggagt acacgagctt gtcgaagagc
    14161 tggtgctgca tgcgcagccc cgccgaagga cccggcccca gaccgaaggc cttggcctcc
    14221 atcgcgtccg cgtaccgcac cgcgcactcg acggccttgt cgaacgcgcc cgccttgccg
    14281 tccttctccg ccttgcgccg cgccgcgttg aagaccttct cgaagatgta cggcacggcc
    14341 aggatgaacg acggccggaa cgccgccagg tcgggcagca gcgccgccgc gttcaggttc
    14401 ggctggtgcc ccatcttgac ccggccgcgc accgccgcga cctgcaccat gcggccgaag
    14461 acgtgcgcga gcggcaggaa gagcagcgtg gtggcctcgt cgccgcgctt ggcgcggaag
    14521 accggctccc agcgctcgac catcacatcc gcctcgaaca tgaagttcgc gtgggagatc
    14581 agacaaccct tgggcttgcc cgtcgtgccg gacgtgtaga tgatcgtcgc gatcgactcg
    14641 ggggtgaccg cgcggcggtg acggtgcacc acctcgtcgt cgatgtccag gcccgcgtcg
    14701 gtcagttcgc ccaccgcgtc ggcatccagc tgccacagcc tgcgcagctg cggcagccgg
    14761 tcgatgaccg aaccgatcgt catcgcgtgg tcctcgtgct cgaccatcgc ggcgctgacc
    14821 tgcgcgtcgt gcagcatcca gacgacctgc tcggccgagg acgtcggata taccggcacc
    14881 acctgggcgc cgatggacca cagcgcgaag tcgaagagcg tccactcata gcgcgtacgg
    14941 gacatgatgg ccacgcggtc gccgaaccgt acgccctgcg cgatcagccc cttcgccagg
    15001 gcgagcacct cgtcgcggaa ggcggccgag gtgacgtcat gccaccgtcc gtccgtcttg
    15061 cggccgaggg cgatgcgcgt cgggtcctcg atggcatggt cgaaaacggc gtcggcaagg
    15121 ccgcccacca gtggcgccga tgccatcgga gggttcgaga actcgcgcaa tgatgctcct
    15181 tgtggcgctc cgcacagcgc cgtgaccgta ccccaattac ttacgctgga gtaagtttcg
    15241 gtgacgtgat ctccaccgaa tctgtacgcg gcgtgcagac ctgcgccgac gggaaacggc
    15301 cccctaccgc cctccggcgc ccactgctgc cttgcgcccc cggtccggag cgcccggggc
    15361 cgccgagccc gtgacgcccg gccgctgacc cgacgacgta cgcaccatga cgagtaccag
    15421 caccccggcc acgagacccg tgacaccggc cgcgagcgac gccccgttca ggcccgccgc
    15481 gaacgcggcc cgcacggagt gctcggagag cgtgccgctc agggcggggg cgccgccgcc
    15541 cgcgacggcg tgcgccgcgt catggccgag cgagtccgcc atgcgggagg tcaggaccgt
    15601 gccgaacagg gcgaccccga ccgcgtatcc gagctggcgg aaggtgttga ccgcgccgcc
    15661 cgccatcccc gagttcgcgg gcggcaccgc ggcgagcgcg gcccccgcga gccccggcgc
    15721 gaccagtccc gtaccgatgc ccgcgatcgt cagcccgggc aggagcgcgt tccaggacga
    15781 cccggcgtcg agcaccgcca tgcagagccc gcccgcgccg atcagcagca gcccgacgcc
    15841 gatgaccagg cgcggcgcca cgccgtgcag cagccgcccg ctgatcgccg ccacgacgaa
    15901 cgaggtcgcc gcgagcggca gcagcaccag gctgccgcgc accgcgctca tgccgagcac
    15961 ggtctgcaac cagatggaga tgtacgggat gacgccgaac gccgccgcgt tgtagccgat
    16021 cgcgccgagc agcaccccgg tgaacgcggg cttgcgcagc agccgcagat cgaggagcgg
    16081 atgggcggtg cgccgctcga cctggacgaa gcagaccagc gcgagcaccg agacgacgaa
    16141 ggccgcgacg gtcgccgccg acgtccaccc ctcggtccca ccgcgcagga cgccgtacgt
    16201 ccccgccccc gcgatgcagg cgaaggcggc cgtgcccgcc cagtcgaccc ggcgcccggc
    16261 ggggcccctg gactccggca cgacccgcag cgtcagccag atggacgcca cgctcaccgg
    16321 caggttcacg aagaagatcc accgccagcc gggcccggcg gtgagcagcc cgcccacgat
    16381 cggcccgagc gcggcggacg ccccgctcac cgcgccccag acgccgagcg cgacggaccg
    16441 ctcgcggtcc tggtaggcgg cggcgagcag cggcagggtc gtcgcgaaca tggccgcggc
    16501 gccaagaccc tgcacggcgc gggccgccac gagcacatcc gcgttggacg cgaggccgca
    16561 gcccagcgag gccagggcga agagcgcggt gcccatcacg tggagccgcc gccggccgag
    16621 cacgtcggcg gcggcgccga cgccgagcag cagcgcggcc agcgcgagcg cgtacccgtc
    16681 gatgacccat tgcagatcgg cgagcgaggc gtccagcgcc cgcgccatgt cgggcagcgc
    16741 caccaccacg atcgtcacgt ccagcaagag catgaatgtc ccgagagaca ccgctgtgag
    16801 cggcccccat gtacgcattt ccgtcttcct ccggctcaag gtccgacgcg tgtgcgtctt
    16861 ctcgtacgat gaggccgcgc cggacgatcc cagcggtacg ggccgctcaa gcgcatggaa
    16921 tcgacatata gggggcctgt aacggtggaa tccgaagcct tcgacgagct ggacctcaaa
    16981 ttgctccacg ccctcgaagt cgacggcagg gcgcccttca gccgtatcgc cgccgtcctc
    17041 ggcgtctccg accagaccgt cgcgcgccgc ttccgccggc tgcgcgccga ggcgggcctt
    17101 cgcgtcgtcg gcgtccgcga cagcgcgcgg ctcggcaggg accagtggat gctgcgcctg
    17161 cgctgtacgc cagacggcgc cgaggcgatc gcggccgccc tggcccgccg ccccgacacg
    17221 gcgtgggtcc acctcacgtc ggccggcacc gaggtggtct gcatgacgct gccccgcgac
    17281 ccgggcgact acgacgacct gctcttcggc aagctcctgc gcacccgcaa actcatcgag
    17341 atcaccgcac accagctcct gcactacttc tacggcggac gcaccggctg gatcggcaag
    17401 caccgcccgc tgaccgacga gcaggtcgcc gccctgcgcc cgaccggacc gccgaccgcc
    17461 cccgggccgg gccccgcccc cgtcagcatc gcccccgaag acgagcccct ggtcgccgcc
    17521 ctgaaggccg acggacgcgt cacctacccc gaactccagc ggctcacggg ccgctccgag
    17581 tccgcggtca aacgccgcgt cgccgcgctg ctcggctccg gcgcgctcta catcgacacc
    17641 gagtacgaca ccgcgtactt cggcttcgcc accgccgcga tgctctgggt caccgtcgac
    17701 cccggagccc tggacgaggt cgggcgggcg atggccgggc accccgagat cgcccacgcc
    17761 tccgcggtca ccgggtccgc caacctgatg gcgaccgtcg tcacccgcga cacggcggag
    17821 ctgtacacct atctgagcgg cagactcggc ccgctggacg gcgtgcggca catcgagtcc
    17881 gcgcccctcc tgcgccgctt caaggaactc acctacccgc gccccctgcg ctagggcctg
    17941 tcccgccgca tgacccgccg gacaggccct aggccccgcg ccgcagccgg tccccgctcg
    18001 ccaggatcgc cgccgcgagc gcgtcggccg ccgcctggtc ggcggcgcgc cgctcgccgt
    18061 gcagcaggac gaagtcgacc gagcccagtt cgggcaggcc cgcccggtcg gagacgcgga
    18121 ccaggcccgg cgggatcagg ccgcgcgagt gcgccatcac gccgaggccc gcgcgggccg
    18181 ccgccaccag gccgttgagg ctgccgctcg tgcaggccac gcgccaggga cggccgcgcc
    18241 gctccagcgc ctcgaaggcg agggcgcgcg tgatgcccgg cggcgggtag acgatcagcg
    18301 gcacggggcg ctcggggtcc aggcgcagcc gctcggagcc gatccacacc agctcgtcgt
    18361 ggcggaccag ctggccccgc gggtcctccg ggcgccgctt ggcgagcacc aggtcgagct
    18421 tgcccgcgtc gagccgctcg tgcagcgtcc cggacagctc gacggtcagc tccagatcga
    18481 cgtccgggtg ggcgtgccgg aaggactcca ggatgtcggt gagccgcgtc aggacgaagt
    18541 cctccgacgc cccgaaccgc agccgcccgc ccagccgcgt ccgcgtgaag aaggccgacg
    18601 cctgctcgtg cacggccagg atgcggcggg cgaaaccgag catcgcctcg ccgtcctcgg
    18661 tcagctcgac gctgtgggtg tcgcgggtaa acagtcggcg cccggtcgcc tcctccagac
    18721 ggcgcacgtg ctggctcacc gtcgactggc gcaggccgag gcgccgggcg gcctgcgtga
    18781 agctcatcgt ctgggcgacc gcgaggaagg tgcggagctg cgaagggtcg tacacgagag
    18841 tcagcctaga cccgctcatc gtgtttcgtg atgacagtca gaacggtgta cgggattcct
    18901 gatcgtgcca ggtgggcgga gcatggagaa ggcatgttcc cgtaccgaca gcatggagcc
    18961 ccgtgaaacg cctgaagtgg ctggcctgga tgccggtcga cccgtacatc gtggcgttgc
    19021 tcgcgaccgt gggcgtcgcg gcgctcgtcc ccgcccgcgg cggcgccgcc gatgccgcct
    19081 cgggggcctc caccgccgcg gtctcgttcc tcttcttcct ctacggggcc cgcctctcca
    19141 cccgcgaggc gctcgacggg ctcaagcact ggcggctcca cctcacggtc ctcgcctgta
    19201 cgttcgtcgt cttcccgctg ctcgggctcg ccgccaaggg cctcgtcccc tacgtcctga
    19261 cgcccgccct ctacagcggc ttcctcttcc tcaccctggt gccgtcgacg atccagtcct
    19321 ccatcgcctt cacctccatg gcccgcggca acgtgcccgc cgcgatctgc gcgggatcct
    19381 tctcctccct ggcgggcatc gtgctcaccc cgctgctcgc ggccgcgctg ctcggcggca
    19441 ccggcggcgg cttctcggcg gactccgtcg tcaagatcgt ggtgcggctg ctcgtgccgt
    19501 tcgtcgccgg gcagctgctg cgccgctggg tcggcggctt cctctcccgg cacaagaagg
    19561 tcctcgggta cgtcgaccgc gggtcgatcc tgctcgttgt ctacaccgct ttcagcgagg
    19621 gcatggtgca gggcatctgg caccaggtga ccccgctgcg gctgctcgcg ctgctcggcg
    19681 tcgaggcggt gctgctcacc gtgatgctgg tgttgacctg gtacggcgcg aagcggctcg
    19741 ggttcggccg cggcgaccgc gtcgcgatcc agttcgccgg ttcgaagaag tccctggccg
    19801 cggggttgcc catggcgagc atcctgttcg gggcgcacgc ctcgctcgcc gtgctgccgc
    19861 tgatgctctt ccaccagatg cagctgatgg tctgcgcggt catcgccaag cgccgctcgc
    19921 gcgatccggt gggcttcggc ggcgaggagg ccgtcagcgg ggctcggcca ggcggagcga
    19981 gacgaaccgc ggccggtaca gcgccacgtt ccggttgatg ttcgcctgcg cgctcgcggg
    20041 caccgggtcc agccagttga cgtcgtaact cagcaccacg cgcccgtcgc ggccgagcgc
    20101 cggatgggcc tgcgggttgt aggcggcggt gtcctggcgt gccgcgctgt ccttcggcag
    20161 gggcgcctcg aaacccttgg cggggccgtg ccaggggccg gtgggcgagc acgaccagta
    20221 cgaggtgacc tcggtcaggc ccttggcgcc cgcggccatg gtgaacagca catacgtccc
    20281 ctcgtcgcgc accaccgtga acgcgctgcc cacccccttc cgcctgccgt ccccgagcac
    20341 cggccgtgac gggccctcgc cccacttctc gccgtcccag tactcccacg cggcggcctc
    20401 ggcgagccgc ccgtgcggga cgcgcgccac atgggcgtgc gaggaggggc gcgaggtggc
    20461 ctgggcgtcg gtgccgccga agacgtacgt ccagccgtcg tcgtcgaccg tcgccgtgcc
    20521 gtacaggacc cgcttctccg ggtccgcgac gcgctgctgg tcggacacct tcacgatccc
    20581 ctcgacgcgc aggtcgggca gggagagcgt ggcgacctcc gtggccatcg ggacgccgta
    20641 gatccagggg ccctggctcg ccatgcggtt ccacagcagg acgcgtacga ccttctcgtc
    20701 cgaggccagg gagcggggct cgacccgtgc ggccaccggc cagcgccact gctggggcgc
    20761 cgggtcggtg aagagcgggg cgggcagggt gcgctccagg gtgcccgagc gggacatcac
    20821 cacggccgag ttgcggacca tgggcgcgtt cgggtcgcgc caggtgtgcg gctggcccgc
    20881 cgtgttgggc ggcgcgtgga cctggccgag gagggtgtcg gagaacagcc acagcacgcg
    20941 cccgtccggc agccgcaccg agtgcgtgcc gtccccgccc gtccagtcgt cggtccgcgt
    21001 cccgtcgtcg ccgtagcgcg tgaacgcgcc ggtgaccttc tcctcggcgg accaggacgc
    21061 caccgtgcgg ggccggcacg ccgtgctcgc gccgtcgccg tcgcctcccc ggtcgtctct
    21121 gggcaggacg acgagcagga cggccgcgag ggcgagggcg agcagcagga ccagccagat
    21181 cctgccgccc accccgtggt gacgttcttg gtcggacacg ccggggacgt tagttgctgc
    21241 cgcgcacgcg gtccatggga agccggacga cggtgtcccg tgtcacaggg gcggcggtgg
    21301 tgcgcagggc ctccacctcg gcgtcgctca gcgccctgtc gtggacccgc acctcgtcga
    21361 tcgccccggt gaagtgggcc cggctgtcga gccgctggcc gatgtgcacg ccgaagggcg
    21421 agttgcggga gaccgagccg ggcacatcgg cggaagtgat ctgcgtaccg tcgacgaaca
    21481 gcgtcaggcg gccgtcgccg cggcgcagcg cgatgtggtg ccactggccg tcgttgtagg
    21541 cgctcgtggt gcgcacggac gcggaccgcg ggggcgtggc gccgtcccgt gtggtgatca
    21601 ggcccgtgac gcggttgctc gcgggctcgc cgcgcagcca cacctgcggc tggttggtgc
    21661 cgatgccgcc catccagagc agcggctgct caccggtggc cgcggagtag cggaaccaca
    21721 gcgaggcggt gaagtcgcgt gacaccagcg ggagttgacg gcggaagggc agtcgtacgg
    21781 cgtcgtcggt gccgtcgaag gagagggcgc cgccgaagcg tccctcggtc tcgcgcgccc
    21841 cgccgagcac ggacgccgat cgggcccagg gggcgtggtc gggggtcttc gggtcgggac
    21901 cgcggcgcgg cttgagccag tcctcggtga agcgggcgaa gcggatctcg tcgcgcgcgt
    21961 cgaccgcgcc gccctcgtac agcaggccga cgtgcgcgcc gtcggcccgc accaggtcgg
    22021 agtagccgga ccagtccgtg gtcaccgtgg ttccccggtc gacgctgtcc caggtgcggc
    22081 cgccgtcgta ggaggagcgg atctgcatcg tgcggcgccg gtcggggtcg ccggggcagc
    22141 cgagcagcat ccgcttgccg aactgca
//
