LOCUS       NZ_CP029617            11329 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 01529 chromosome, complete genome.
ACCESSION   NZ_CP029617
VERSION     NZ_CP029617.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 01529
  ORGANISM  Streptomyces sp. WAC 01529
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. May-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 202.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945545.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:27:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,297
            CDSs (total)                      :: 7,207
            Genes (coding)                    :: 7,110
            CDSs (with protein)               :: 7,110
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 33 of 97
            Pseudo Genes (incomplete)         :: 81 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6504125
            Orig. end                         :: 6515454
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029617.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11329
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="22"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11329
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11329
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6329](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6329)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(428..2059)
                     /locus_tag="DMA15_RS28995"
                     /old_locus_tag="DMA15_28980"
     CDS             complement(428..2059)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (117-484). E-value:
                     1.1e-21. Score: 69.4. Matches aSDomain:
                     nrpspksdomains_DMA15_RS28995_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643866.1"
                     /locus_tag="DMA15_RS28995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_28980"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_125515676.1"
                     /sec_met_domain="PF00561 (E-value: 6.9e-26, bitscore: 90.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAAAARYGTAGSLVLTALVAAPAGSASATPPSPEAHGTAVAAQR
                     AEAAGIRWGICAKAERLPATLQCGTVSVPLDYAHPHGEQIKLTVSRTKPKAKAKKHGTA
                     KGTAKGKAVARQGALVFNPGGPGASGMYFPMIGVMPEWKRVAAAYDLIGYAPRGVGRSA
                     PLSCQDPKEFGKAPSSAPVHPDDAYKQERIARAKAYARGCAARNPGLRHYTTLNNARDL
                     DVLRAALGEKKLTFMGASYGTYFGAVYATLFPTHVRRMVFDSAVNPAPAQIWYRNNLDQ
                     SAAFERRWADFRTWVAKHDKTYHLGTTPEKVMENYEKVRDELGRKPAGGKVGQGQLHAA
                     YLQAGYYDDYWPERAKALSAYLKGDPKPLIEQAAPERRAAADDENGNAVYTAVECNDAP
                     WPTDFATWDRDNTLLARLAPFETWDNAWMNLPCAYWQAPRQQPLDVRADGDELAPTLIL
                     AAERDAATPYEGARELHRRLANSVLVTEREAGTHGIGGGPNECVNGYLEAYLLEGRLPV
                     RRAACAPHKEPRPESGGRAVERPRAL"
     aSDomain        complement(608..1708)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS28995_Abhydrolase_1.1"
                     /evalue="1.10E-21"
                     /label="DMA15_RS28995_Abhydrolase_1.1"
                     /locus_tag="DMA15_RS28995"
                     /protein_end="484"
                     /protein_start="117"
                     /score="69.4"
                     /tool="antismash"
                     /translation="ALVFNPGGPGASGMYFPMIGVMPEWKRVAAAYDLIGYAPRGVGRS
                     APLSCQDPKEFGKAPSSAPVHPDDAYKQERIARAKAYARGCAARNPGLRHYTTLNNARD
                     LDVLRAALGEKKLTFMGASYGTYFGAVYATLFPTHVRRMVFDSAVNPAPAQIWYRNNLD
                     QSAAFERRWADFRTWVAKHDKTYHLGTTPEKVMENYEKVRDELGRKPAGGKVGQGQLHA
                     AYLQAGYYDDYWPERAKALSAYLKGDPKPLIEQAAPERRAAADDENGNAVYTAVECNDA
                     PWPTDFATWDRDNTLLARLAPFETWDNAWMNLPCAYWQAPRQQPLDVRADGDELAPTLI
                     LAAERDAATPYEGARELHRRLANSVLV"
     misc_feature    complement(2097..2113)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.74"
                     /tool="antismash"
     misc_feature    2102..2115
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.6"
                     /tool="antismash"
     misc_feature    complement(2130..2144)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.89"
                     /tool="antismash"
     gene            complement(2169..2942)
                     /locus_tag="DMA15_RS29000"
                     /old_locus_tag="DMA15_28985"
     CDS             complement(2169..2942)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983660.1"
                     /locus_tag="DMA15_RS29000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_28985"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_125515677.1"
                     /transl_table=11
                     /translation="MFWVPLLLLAWAVTGLACGRLCLAASRAADQERAAPRGHELTLYE
                     AAFLSGGPARVADVALVAMARARRLLIAHTGWATVVDPVGRDDMERSVLGAIGPAGQSR
                     IAPIRRGAATAEAVRALADRLVAAGLAVPEGVGSHVASAVRQVRAATVAVLALGAAAVL
                     MPAQGQGASGQVPVAVWFGLPLLMCVGCLAIARVEVHPYTRWASPAGQRLLGALPTRDD
                     QLAAVAVRGVRAVAEPELRAALTDRGRRGVAQGGL"
     misc_feature    2975..2990
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.4"
                     /tool="antismash"
     gene            complement(2983..3792)
                     /locus_tag="DMA15_RS29005"
                     /old_locus_tag="DMA15_28990"
     CDS             complement(2983..3792)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643868.1"
                     /locus_tag="DMA15_RS29005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_28990"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_125515678.1"
                     /transl_table=11
                     /translation="MRSPAINGTGLIVAGLVATLAALLFPLWSYEDRSGTGLDRLNAET
                     VSTDFGPLSALDRDFITKVRLAGLWELPAGQQAEERGTTKAVRTAGEHLVEGHAFLDAR
                     VREVATRLSLELPSQPNPQQRRWLAELSRARGETYNQKFANILRRAHGKVFSVVAEVRA
                     NTRNSLVRALADDANTTVLDHITVLEATGLVDFEGIARDAATAGPPPLTRSPAPPGPAT
                     SPDPATPVTPSPTYPLPPAASRPEPERPNARPQTERYIPVTPRPHSE"
     misc_feature    complement(3795..3811)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.35"
                     /tool="antismash"
     gene            complement(3911..4996)
                     /locus_tag="DMA15_RS29010"
                     /old_locus_tag="DMA15_28995"
     CDS             complement(3911..4996)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="DMA15_RS29010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_28995"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_125515679.1"
                     /transl_table=11
                     /translation="MSIAGIMYTVLVLASSAALIRGVVAAGRPQGPDPAGDDHGDFVRG
                     TWEAAFLSGGPARLADALIAGLHDDGRLVVAGPGVVGIPRPTARNPAEQAVIDTHRAAP
                     SASLHWLRAAVTHSGPVRETGDALAARGLLMRPGPRRTWRTWAGAQLFACFLGFLVASM
                     LTVAQYADDAAQLGGTDRVLDAILHMVPASVIGFAIALGCLSVTEKQLTAAGRRALDEY
                     VASSGHLTGAAHLVATRGLAAAHPDLRAQLIAAARVRRRTPAAAGPHLAPSRDPGAWGG
                     PSGFACSGRSGCGSGSGAACSGGGLACSGGSGYACSSGGGSACSGGSGVACSSGGGGSS
                     CSGGGGGGGGGSSCSSSSSSF"
     gene            complement(5001..6329)
                     /locus_tag="DMA15_RS29015"
                     /old_locus_tag="DMA15_29000"
     CDS             complement(5001..6329)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122140.1"
                     /locus_tag="DMA15_RS29015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29000"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_125515680.1"
                     /sec_met_domain="DUF692 (E-value: 8.5e-97, bitscore: 322.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRLGTGIGWRPEIADAVEAMPGIDWVEAVAENVCPGHLPDSLLR
                     LRERGVTVVPHGVSLGLGGADRPDEGRLTALAERALALGSPLVTEHIAFVRAGGDLTAT
                     QPLEAGHLLPVPRTRDALAVLCENVRIAQDALPVPLAVENIAALISWPGEEMTEGQFLY
                     ELVERTGVRLLIDVANLHTNHVNRGEDPAKALDELPVEAIAYVHVAGGFERAGVWHDSH
                     AHPVPEPVLAILADLASRVTPPGVLLERDENFPEPAELERELDAIRATVWGAAGPGAGS
                     GVDPADGRREGLPGGPLGELPPTAAARQRSALAQAALLSALVAGTPAPEGFDRVRLKVQ
                     SQALAAKRADVVAKVAPELPGILGAAYRADFLAYAHSRPMTGGYRQDALGFAEYLLLAG
                     RPEDADARARLSDWWLERSGPAPLSRGPAARLLQATRRVLLRR"
     gene            complement(6446..7213)
                     /locus_tag="DMA15_RS29020"
                     /old_locus_tag="DMA15_29005"
     CDS             complement(6446..7213)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643870.1"
                     /locus_tag="DMA15_RS29020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29005"
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_125515681.1"
                     /transl_table=11
                     /translation="MRRVNGTALIIAALVATLGAIAFPVWSYADRSGTGPANLAAGSVA
                     TQWGPLSAADRDLLVKVRLAGLWEIPAGQQAVERAPTEAIKEAGDHLIVGHTDLDQRAR
                     TTAAKLGVELPNQPTEQQQGWLKELTEASGETYQRKFANLLRVAHGKVFSVVAQVRDTT
                     RNSLIRQLATDANQTVLDHITMLEATGLVDFDGIANDAASNATASPSGPPPPSGVTPPE
                     PVPARPSGDISTTSRPSPGPPGQINTGRPEPQM"
     gene            complement(7363..8121)
                     /locus_tag="DMA15_RS29025"
                     /old_locus_tag="DMA15_29010"
     CDS             complement(7363..8121)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128420.1"
                     /locus_tag="DMA15_RS29025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29010"
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_240659990.1"
                     /transl_table=11
                     /translation="MSDENTTAENTSAESTTAQDSPFRHETTSRDEAPQFVLPLVARIE
                     RAAPPARTDALETAARAVLVMLSDERSLGDGEWAQAMRDWQDARIRKVVRRARGAEWRR
                     AEALPGLTVTGKSAEVRVFPPVPLDGWPKELARLQVSGTDLDDPEPPAGADPTHPVLWM
                     SPDLDMSAGKAMAQAGHGAQLAWWELSAEDRTAWRDAGFPLSVRTPEAAHWRELTASGL
                     PVVRDAGFTEIAPGSCTVVADHPALRPPRP"
     gene            8204..9199
                     /locus_tag="DMA15_RS29030"
                     /old_locus_tag="DMA15_29015"
     CDS             8204..9199
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012999909.1"
                     /locus_tag="DMA15_RS29030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29015"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_125515683.1"
                     /transl_table=11
                     /translation="MERDLVVRLGGVGRRYGVRGPWVLRGVDLGVRAGALVRVEGANGS
                     GKSTLLRLLAGIDAPSEGRVTGRPRTAYVPERFPAAMPFTAIGYLTHMARIHGVARGAA
                     SRGAAARSAERWLERFGAAEYARTPLSELSKGSSQKVAVAQALLAAPDLLVLDEAWTGL
                     DAPARAELDRAVAERTAAGGAVAFVDHDPGRLAGAVDETYGVVGTGPGEAERVPRALRI
                     RRGWSRSSPHPQAAPPLGALMRGRHVVIETRGPRGAELPAPVAAAATVVTDAPEGAIRF
                     TVPESRSDLVLRELLTAGPPWHVVTVTRAPAGAPVPPQAPAQAPTEGRGR"
     gene            9199..9867
                     /locus_tag="DMA15_RS29035"
                     /old_locus_tag="DMA15_29020"
     CDS             9199..9867
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997023.1"
                     /locus_tag="DMA15_RS29035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29020"
                     /product="ABC transporter"
                     /protein_id="WP_125515684.1"
                     /transl_table=11
                     /translation="MSALLTYQAALLARSQRWLAPVILYAVFLAVGVQSGQPVLDSLAY
                     AAAALLPVAAWLVRICVSNEPPAARSCSAAAAGPGRAHLASLLAAFLAASALGALAVLV
                     VTVMSDGASTNGRLPVPRVPAGAAGLIAMLVSALLGTAVGALTNWPLLRSPAKSVPTML
                     LAALLLLVTTGSPAQSVLTDLTTGSREGSVPWPLGALAGAVVAAVAAGWAACAMSSRRG
                     "
     gene            complement(9896..10051)
                     /locus_tag="DMA15_RS36805"
     CDS             complement(9896..10051)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675663.1"
                     /locus_tag="DMA15_RS36805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_164551845.1"
                     /transl_table=11
                     /translation="MTDGDHGAETGADRPECVLCQAPTEYPESHRGITLCPPCEWQEAQ
                     RTMCSG"
     gene            complement(10061..10933)
                     /locus_tag="DMA15_RS29040"
                     /old_locus_tag="DMA15_29025"
     CDS             complement(10061..10933)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003993757.1"
                     /locus_tag="DMA15_RS29040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_29025"
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_125515685.1"
                     /transl_table=11
                     /translation="MITLVRRRAALCALGALTTVLAGCSSGDTTASGHPGRQARPAASA
                     SPAAPPTLAPGPSGLTPVFSNGSRTQGRTVALTFDADMTVNQGARAAAGERFDHPELVA
                     TLRRLKVPATFFMTGRWAEEYPDQAKAIGKDPLFEVANHSYSHHAFTGDCYGLPTVPPE
                     RMRADMERAFDAFRKAGVERPLPYFRFPGGCYDQRSLRALAPGGVTAVQWDVVSGDAFA
                     TDADAVARQVIDGVRPGSVVVMHCTRSAAPTTERALRTIVPKLRERGFRFVRVSEQIGS
                     TRGAAGARG"
     misc_feature    complement(10926..10941)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.79"
                     /tool="antismash"
     misc_feature    complement(10954..10971)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 18.77"
                     /tool="antismash"
ORIGIN
        1 gccctggagc cggtctggtc gaacatggcg ctgcaccgcc ccgccgagtt caacaagtcg
       61 cacatcccgg ccttcctcgc cgacgagacg ccccgcgact acgtctccgt ctaccccttc
      121 gtgcgctcct acgactggta cctgctgccc gacgaggacc gccgccgcat gctcgccgac
      181 cacggcaaga tggcccgcgg ctaccccgac gtgcgcgcca acaccgtcgc ctcgttctcc
      241 ctcggcgact acgagtggct gctcgccttc gaggccgacg agctgtaccg catcgtcgac
      301 ctcatgcgtc acctgcgcgc ctccgaggcc cggatgcacg tacgtgaaga ggtgccgttc
      361 tacaccggcc gccgcaagtc cgtcgcggac ctcgtcgcgg gcctggcgta accgcgggac
      421 gggtcggtca gagcgccctc gggcgctcca ccgcccgccc gccggactcc ggccggggct
      481 ccttgtgcgg tgcgcacgcc gcgcgccgca ccgggaggcg gccctccagg aggtacgcct
      541 ccaggtatcc gttgacgcac tcgttggggc cgccgccgat gccgtgcgtg cccgcctccc
      601 gctcggtgac gagcaccgag ttcgccagcc tgcggtgcag ctctcgcgcc ccctcgtacg
      661 gggtcgcggc gtcgcgctcg gcggccagga tcagcgtcgg ggccagctcg tcgccgtccg
      721 cgcgcacgtc gagcggctgc tgccggggcg cctgccagta ggcgcacggc aggttcatcc
      781 aggcgttgtc ccaggtctcg aagggcgcga ggcgcgcgag gagcgtgttg tcgcggtccc
      841 aggtggcgaa gtccgtcggc cagggggcgt cgttgcactc cacggccgtg tagacggcgt
      901 tgccgttctc gtcgtcggcg gccgcgcgcc gctcgggcgc ggcctgctcg atcagcggct
      961 tcgggtcgcc cttcagatac gcggagagcg ccttggcccg ctccggccag tagtcgtcgt
     1021 agtacccggc ctggaggtac gcggcgtgga gctggccctg accgaccttg cctcccgcgg
     1081 gctttcggcc cagctcgtcg cgtaccttct cgtagttctc catgaccttc tcgggcgtcg
     1141 tgcccaggtg gtacgtcttg tcgtgcttgg ccacccaggt gcggaagtcc gcccagcgcc
     1201 gctcgaaggc cgccgactgg tcgaggttgt tgcggtacca gatctgcgcg ggggcggggt
     1261 tgaccgccga gtcgaagacc atgcggcgca cgtgcgtcgg gaagagcgtc gcgtagacgg
     1321 ccccgaagta ggtgccgtac gaggcaccca tgaacgtcag cttcttctcg ccgagcgcgg
     1381 cccgcagcac gtccaggtcg cgcgcgttgt tcagggtcgt gtagtgccgc aggccggggt
     1441 tgcgggccgc gcacccgcgc gcgtacgcct tcgcccgcgc gatgcgctcc tgcttgtacg
     1501 cgtcgtcggg gtggaccggg gccgatgagg gtgccttgcc gaactccttc gggtcctggc
     1561 aggagagcgg ggccgagcgg ccgacaccgc gcggcgcgta gccgatgagg tcgtaggcgg
     1621 cggcgacgcg cttccactcg ggcatgacgc cgatcatcgg gaagtacatg ccggacgcgc
     1681 cgggtccgcc ggggttgaag acgagcgctc cttgccgggc gacggctttc cccttcgccg
     1741 tccccttcgc cgtcccgtgc ttcttcgcct tcgccttcgg cttggtgcgg ctgacggtca
     1801 gtttgatctg ctcgccgtgg gggtgcgcgt agtccagcgg cacggagacc gtgccgcact
     1861 ggagggtggc gggaaggcgc tcggccttgg cgcagatgcc ccagcggatc ccggcggcct
     1921 cggcgcgctg ggcggcgacg gcggtgccgt gcgcctcggg ggagggcggg gtggcgctcg
     1981 cgctccccgc gggggcggcg acgagggcgg tcaggaccag ggatccggcg gttccatagc
     2041 gggcggctgc tgctctcatc gcgcttcact acctcttttg ttcggccatg cgttccaggc
     2101 gatcttcgaa caaaagggat gattcgtgtg atattcggag aagtaaagca ccggtcgccg
     2161 gtgtcggctc aaagcccccc ttgcgcgacc ccccgccgcc cccggtcggt gagggcggcc
     2221 cgcagctccg gctcggcgac cgcgcggacc ccgcgcacgg ccacggcggc cagctggtcg
     2281 tcccgggtgg gcagcgcgcc aaggagccgc tgaccggcgg gcgacgccca ccgcgtatac
     2341 ggatggacct cgacgcgggc gatcgccaga caccccacgc acatgagcag cggcagcccg
     2401 aaccagaccg cgaccggcac ctgccccgag gctccctgtc cctgcgccgg catgaggacc
     2461 gccgcggcgc cgagcgcgag cacggccacc gtcgccgccc gcacctggcg gacggcggag
     2521 gcgacatggg aacccacgcc ctccgggacg gcgagccccg cggcgacgag ccggtccgcg
     2581 agcgcccgca cggcctcggc ggtggccgcg ccccggcgta tcggggctat ccgcgactgg
     2641 cccgccgggc cgatcgcgcc gagcacggaa cgctccatgt cgtcgcggcc caccgggtcg
     2701 accacggtcg cccaccccgt gtgcgcgatg agcagccgcc gcgcccgggc catcgccacc
     2761 agcgccacgt cggcgacgcg ggcgggcccg ccggagagga acgcggcctc gtagagcgtg
     2821 agttcgtggc cgcgcggcgc cgccctctcc tggtcggcgg cgcggctcgc ggccagacag
     2881 aggcgaccgc aggcgaggcc ggtgacggcc caggcgagga ggagcagagg gacccagaac
     2941 atggcggtgt ttctatgcga agcggtcact gggcgccacg ggttattcac tatgcggacg
     3001 cggggtgacg ggtatataac gttccgtttg cggccgggcg ttcggcctct ccggctcggg
     3061 gcgggacgcg gcgggcggca ggggatacgt cggtgacggg gtgaccggcg tggccgggtc
     3121 cggtgaggtg gccgggcccg gtggcgcggg ggagcgggtc aggggcggcg ggcccgcggt
     3181 cgccgcgtcc cgggcgatgc cctcgaagtc gacgaggccg gtggcctcca ggacggtgat
     3241 gtggtcgagg acggtcgtgt tcgcgtcgtc ggcgagggcc cgcaccagtg agttgcgggt
     3301 gttcgcgcgg acctcggcca ccaccgagaa caccttgccg tgcgcgcgcc gcaggatgtt
     3361 ggcgaacttc tggttgtacg tctccccgcg cgcccggctc aactcggcga gccagcgccg
     3421 ctgctggggg ttgggctggc tgggcagttc gaggctgagc cgggtggcga cctcccgtac
     3481 gcgcgcgtcc aggaacgcgt gcccctcgac gaggtgctcg cccgcggtcc gcaccgcctt
     3541 ggtcgtgccg cgctcctccg cctgctgtcc ggcgggcagt tcccacaggc ccgcgaggcg
     3601 gaccttggtg atgaagtccc ggtccagggc ggagagcggc ccgaagtcgg tcgacaccgt
     3661 ctcggcgttg agtcggtcga ggccggtgcc cgagcggtcc tcgtaggacc agagggggaa
     3721 gagcagcgcg gccagggtcg cgacgagtcc cgcgacgatg aggcctgttc cattgatggc
     3781 tggggatcgc atggtgcctc ctgttgcggc accgcacgtt agtgcgcctc gggcgcggga
     3841 tgacgggtta tcgcggggtg tacgtcagct gccgtacggc tgtgtggggc ggggccgttg
     3901 gcgggtgccc tcagaaggag gaggacgagc tgctgcaact ggacccgccg cctccgccgc
     3961 caccaccccc ggagcaggag gagccgccgc ctccactgga gcaggccacc ccgcttccgc
     4021 cggagcaggc agacccgcct ccacttgagc aggcgtagcc gctcccgccg gagcaggcca
     4081 agccgccgcc ggagcaggcc gccccgctcc cggagccgca gccggagcgg cccgagcagg
     4141 cgaagccgct ggggccgccc cacgccccgg gatcccggga cggggcaagg tgcgggcccg
     4201 ccgcagcagg cgtccgcctc cgcacgcggg cggcggcgat cagctgggcg cgcaggtcgg
     4261 ggtgggccgc cgcgaggccg cgggtcgcca cgaggtgcgc cgcgcccgtg aggtggcccg
     4321 aggaggcgac gtactcgtcg agagcgcggc gccccgcggc ggtgagctgc ttctcggtga
     4381 ccgagaggca gcccagggcg atcgcgaaac cgatgacgct ggcgggcacc atgtggagga
     4441 tggcgtcgag gacgcggtcg gtgccgccga gctgcgccgc gtcgtccgcg tactgcgcca
     4501 cggtcagcat ggaggccacg aggaacccca ggaagcacgc gaagagttgc gccccggccc
     4561 aggtccgcca cgtccgccgc gggcccggcc gcatgaggag gccgcgtgcc gccagcgcgt
     4621 cgcccgtctc ccgcaccggg ccgctgtgcg tcacggccgc gcgcagccag tgcagggagg
     4681 cgcttggcgc cgcgcggtgg gtgtcgatga cggcctgctc ggcggggttc ctcgccgtgg
     4741 gccgggggat gccgacgacg ccgggcccgg ccacgaccag gcggccgtcg tcgtgcaggc
     4801 ccgcgatcag cgcgtcggcg agccgggcgg gaccgccgga gaggaacgcg gcctcccacg
     4861 tcccgcgcac gaagtcgccg tggtcgtccc cggccgggtc cgggccctgg gggcgcccgg
     4921 ccgccaccac gcctctgatc agcgcggcgg aggaggccag gacgaggacc gtgtacatga
     4981 ttcccgcgat gctcaccgtg tcaccgcctc agcaggaccc gccgggtggc ctggagcagt
     5041 cgggcggcgg gcccccgcga caggggcgcg gggccggagc gctccagcca ccagtcgctc
     5101 aaccgcgccc tggcgtcggc gtcctcgggc cgcccggcga gcagcaggta ctcggcgaag
     5161 cccagcgcgt cctggcggta gccgcccgtc atgggccggg agtgggcgta ggcgaggaag
     5221 tcggcgcggt acgccgcgcc gaggatgccc ggcagctcgg gcgcgacctt cgcgacgaca
     5281 tcggcccgct tggcggccag cgcctggctc tgcaccttca gccgcacccg gtcgaaccct
     5341 tcgggcgccg gggtccccgc gacgagcgcg gagagcagag cggcctgcgc gagggcgctg
     5401 cgctggcggg cggcggcggt cggcgggagt tccccgagcg gcccgccggg gaggccctca
     5461 cggcgcccgt cagcggggtc cacgcccgaa cctgctcccg gacccgccgc cccccacacc
     5521 gtggcccgga tcgcgtccaa ctcgcgctcc agctccgccg gttcggggaa gttctcgtcc
     5581 cgctccagga ggacccccgg cggggtcacc cgggaggcga ggtcggccag gatggcgagc
     5641 accggttccg gtacggggtg cgcgtggctg tcgtgccaga cgccggcccg ctcgaagccg
     5701 cccgccacat ggacgtacgc gatggcctcg accggcagct cgtccagcgc cttggccggg
     5761 tcctcgccgc ggttgacgtg gttcgtgtgg aggttggcga cgtcgatgag cagacgtacg
     5821 cccgtacgct cgaccagctc gtacaggaac tgcccctccg tcatctcctc gcccggccag
     5881 gagatcagcg cggcgatgtt ctccacggcg agcggcactg gcagcgcgtc ctgcgcgatg
     5941 cggacgttct cgcagagcac ggcgagcgcg tcgcgggtgc gcggcaccgg cagcagatgc
     6001 ccggcttcga ggggctgcgt ggcggtgagg tcgcccccgg cgcgtacgaa ggcgatgtgc
     6061 tcggtgacca gcggcgagcc gagcgccagc gcccgctcgg cgagcgcggt cagccgcccc
     6121 tcgtcggggc ggtcggcgcc accgaggccg agggagacgc cgtgcggcac gacggtcacg
     6181 ccgcgctcgc gcagccgcag cagggagtcg ggcagatggc ccggacagac gttctccgcg
     6241 acggcctcta cccagtcgat gccgggcatc gcctccacgg cgtccgcgat ctccggacgc
     6301 cagccgatac cggtccccag acgccgcatg gcgctcccct ttcgtccccc ggtctcccgg
     6361 tcccccgaat cggtcccccc gatcccgtcc ccgggtcatt caccggggcg gggtcggccg
     6421 aaccctcagg gggagacgtt cagagctaca tttgaggttc cggccgtccg gtgttgatct
     6481 gtccgggcgg gccgggcgag gggcgggacg tggtggagat gtcgccgctc ggccgggcgg
     6541 gcacgggctc cgggggagtg accccggacg gcgggggagg cccggagggg ctggcggtcg
     6601 cgttcgacgc ggcgtcgttc gcgatcccgt cgaagtcgac gagcccggtg gcctccagca
     6661 tcgtgatgtg gtcgaggacg gtctggttgg cgtccgtggc gagctgccgg atcagggagt
     6721 tgcgggtggt gtcgcgcacc tgggcgacca cgctgaacac cttgccgtgc gcgacccgca
     6781 gcaggttcgc gaacttgcgc tgatacgtct cgccgctcgc ctccgtcaac tccttcagcc
     6841 agccctgctg ttgctcggtg ggctgattgg gcagctccac gccgagtttc gcggcggtgg
     6901 tgcgggcccg ctggtcgagg tcggtgtggc cgacgatgag gtggtcgccc gcctccttga
     6961 tggcctcggt cggcgcgcgc tccacggcct gctggccggc cggtatctcc cagagcccgg
     7021 cgagccgcac cttcaccagc agatcccggt cggccgccga gaggggcccc cactgggtgg
     7081 ccacggaccc ggcggccaga ttggcgggcc ccgtgcccga gcggtcggcg tacgaccaca
     7141 cggggaacgc gatcgccccg agcgtggcga cgagcgccgc gatgatcaga gccgtgccgt
     7201 tgacgcgccg caaggtgcct cccgtgtcgc tcccgtactc ccccggtgat accgaggagt
     7261 acggaagata cgggtggggt gttcaaacgc gcgagaggtt gtacgaattg gcgtgcgtgc
     7321 tgacgtgtcg acgtgttgac gtgctgcggt gcgcggcgcc ggtcacggcc ggggcgggcg
     7381 cagggcgggg tggtcggcga ccaccgtgca ggaacccggg gcgatctccg tgaagcccgc
     7441 gtcgcggacc accggcagcc ccgaggcggt cagttcacgc cagtgggcgg cctcgggggt
     7501 gcgcacggag agcggaaaac cggcgtcgcg ccaggccgtg cggtcctcgg ccgacagctc
     7561 ccaccaggcc agctgggcgc cgtggcccgc ctgcgccatc gccttgcccg ccgacatgtc
     7621 gaggtcgggg ctcatccaca ggacggggtg cgtcgggtcg gccccggccg ggggctcggg
     7681 gtcatccagg tccgtgccgg agacctggag ccgcgccagc tccttgggcc agccgtccag
     7741 cgggaccggc gggaagacgc ggacctccgc cgacttgccg gtgacggtga gaccgggcag
     7801 cgcctccgcc ctgcgccact cggcgccccg cgcccggcgc accaccttgc ggatgcgggc
     7861 gtcctgccag tcgcgcatgg cctgcgccca ctcgccgtcg ccgagggaac gctcgtcgct
     7921 cagcatcacc aggacggcgc gggccgcggt ctccagggcg tcggtgcggg ccgggggagc
     7981 ggcgcgttcg atgcgggcga cgaggggcag cacgaactgc ggggcctcgt cgcgcgaggt
     8041 ggtctcgtgc cggaaggggc tgtcctgggc ggtggtgctc tccgcggagg tgttctcggc
     8101 ggtggtgttc tcgtcgctca cgcgtccagt ctgccaggcg ggagttccgc ccccgccggg
     8161 gctcggggcg gcccggggag gggcgtgcgc gaggatggcc cgcatggaac gtgatctcgt
     8221 ggtgcggctg ggcggggtgg gccggcgcta cggcgtgcgc ggcccatggg tgctgcgcgg
     8281 tgtcgatctc ggcgtgcgtg cgggtgccct ggtgcgggtg gagggcgcca acggcagtgg
     8341 caaatcgacc ctgttgcggc tcctcgccgg tatcgacgcg ccctccgagg ggcgggtgac
     8401 ggggcgcccg cgcacggcgt acgtccccga acgcttcccc gcggccatgc cgttcaccgc
     8461 gatcggctac ctcacgcaca tggcgcggat ccacggtgtc gcgcggggtg cggcgagccg
     8521 gggtgcggcg gcgcggagcg cggaacggtg gctggagcgc ttcggcgccg ccgagtacgc
     8581 gcgtacaccg ctctccgaac tctccaaggg cagcagccag aaggtcgccg tggcacaggc
     8641 gctgctggcc gcccccgacc tgctcgtcct cgacgaggcg tggaccggcc tggacgcccc
     8701 cgcccgcgcg gaactcgacc gcgcggtggc ggagcgcacg gcggcgggcg gcgcggtcgc
     8761 cttcgtggac cacgatccgg ggcggctcgc gggggcggtg gatgagacgt acggggtggt
     8821 cgggacgggg ccgggggagg ctgagcgggt ccctcgtgcc ctgcgcattc gtcgtggctg
     8881 gtcgcgcagt tccccgcacc cccaggcggc tccgccgctg ggggcgctca tgcgggggcg
     8941 gcacgtggtc atcgagacgc ggggcccgcg gggcgcggag ctgccggctc cggtcgccgc
     9001 ggcggcgacc gtcgtgaccg acgctccgga gggagccata cggttcacgg tcccggaaag
     9061 ccgctctgac ctggtcctgc gggaactcct gacggcggga ccgccctggc acgtggtgac
     9121 ggtgacacgc gcgccggcgg gggcgccggt cccgcctcaa gccccggcgc aggctcccac
     9181 tgaagggcgg ggccggtgat gagcgctctc ctcacctacc aggcggccct gctggcgcgg
     9241 tcgcagcggt ggctcgcgcc ggtgatcctc tacgcggtct tcctggccgt cggcgtccag
     9301 agcgggcagc ccgtcctcga ctccctcgcc tacgcggcgg ccgcactgct gccggtcgcc
     9361 gcctggctgg tgcgtatctg cgtgagcaac gaaccgcccg cggcgcgcag ttgctccgcc
     9421 gccgcggccg ggccggggcg tgcgcacctg gcctcgctgc tggcggcgtt ccttgccgcg
     9481 tccgcgctgg gcgcgctggc cgtgctcgtg gtgacggtca tgagcgacgg ggcgtccacc
     9541 aacgggcgcc tgcccgtgcc tcgcgtcccc gcgggcgccg caggcctcat cgcgatgctg
     9601 gtcagcgcgc tgctcggcac ggccgtcggc gccctcacca actggcccct gctgcgctcc
     9661 ccggccaagt ccgtccccac gatgctgctc gccgcgctgc tcctcctggt cacgacgggc
     9721 tccccggccc agtcggtgct gacggacctg acgaccggct cacgagaggg ctcggtcccc
     9781 tggccgctgg gcgcgctggc cggggcggtg gtcgcggcgg tggcggcggg atgggcggcc
     9841 tgcgcgatga gttcgcggcg cgggtgaggt cggtgccgtc cggccgcccg ctcgctcagc
     9901 ccgagcacat ggtgcgctgg gcctcctgcc attcgcaggg cgggcagagc gtgatgcctc
     9961 tgtgggactc cgggtactcc gtgggcgcct ggcacaggac gcactcgggc ctgtccgccc
    10021 ccgtctccgc gccgtggtcg ccgtccgtca tgcgtccagc ctagccccgc gcccccgccg
    10081 ctccccgggt cgaaccgatc tgctccgaca cccgcacgaa acggaagccc cgctcccgca
    10141 gcttcgggac gatcgtccgc agcgcgcgtt ccgtcgtcgg ggccgcgctg cgcgtgcagt
    10201 gcatgacgac gaccgacccc ggccgcaccc cgtcgatcac ctggcgggcc accgcgtccg
    10261 cgtccgtcgc gaaggcgtcg ccgctgacca cgtcccactg cacggcggtg acgccgccgg
    10321 gcgcgagcgc gcgcagggac cgctggtcgt aacagccgcc ggggaagcgg aagtacggca
    10381 acgggcgctc gacgcccgcc ttgcggaacg cgtcgaaggc acgctccatg tccgcccgca
    10441 tccgctccgg gggcacggtc ggcaggccgt agcagtcacc ggtgaaggcg tggtggctgt
    10501 aggagtggtt ggcgacctcg aagagcgggt ccttgccgat ggccttggcc tggtccggat
    10561 actcctccgc ccagcgaccc gtcatgaaga aggtcgcggg caccttcagc cggcgcagcg
    10621 tcgcgaccag ctcgggatgg tcgaaccgct cgcccgccgc ggcgcgtgcc ccctggttca
    10681 cggtcatgtc cgcgtcgaag gtcagcgcga cggtacggcc ctgggtgcgg gagccgttgc
    10741 tgaagacagg ggtgaggccc gaggggccgg gcgcgagcgt gggcggggcg gccggcgacg
    10801 cggaggccgc gggccgtgcc tggcggcccg ggtggccgga ggccgtggtg tcgccggacg
    10861 agcacccggc gaggacggtg gtcagagcgc ccagggcgca gagagcggcg cgtctccgta
    10921 cgagagtgat cacgcggtga cgatatgtgc gcgaatccga taaacaggtt atcggcccac
    10981 atgtccgcct cgatgccacc cgtctgggcc ggaagcaggg gcaggaagca cgggtcggaa
    11041 gcccgggtcg ggggctcggc ggcagacagc gaccccgtcg gcagcgtggt ggtttattgc
    11101 gttgcgggga ggtcgaagaa cgttttagcc tcgcgtggtt ccgtcggtgc ccgttccggg
    11161 gccccggcgc tgtgtttcga ggtgatgacg tatctcccag gccaagtagc cgctcgttct
    11221 gaggctcttt tccggttgtc cgcgatcgcg ggctcccgac gcatgcctcg acggcggtgc
    11281 tcccgatggc ctgggcttgt cgcaccctgc tcccccctgt cgcgccgta
//
