LOCUS       NZ_CP029617            10405 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 01529 chromosome, complete genome.
ACCESSION   NZ_CP029617
VERSION     NZ_CP029617.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 01529
  ORGANISM  Streptomyces sp. WAC 01529
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8270461)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. May-2016
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 202.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945545.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 04:27:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,297
            CDSs (total)                      :: 7,207
            Genes (coding)                    :: 7,110
            CDSs (with protein)               :: 7,110
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 97
            CDSs (without protein)            :: 97
            Pseudo Genes (ambiguous residues) :: 0 of 97
            Pseudo Genes (frameshifted)       :: 33 of 97
            Pseudo Genes (incomplete)         :: 81 of 97
            Pseudo Genes (internal stop)      :: 9 of 97
            Pseudo Genes (multiple problems)  :: 22 of 97
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:50:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1763630
            Orig. end                         :: 1774035
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029617.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="6"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](+)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5405
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            889..1989
                     /locus_tag="DMA15_RS07965"
                     /old_locus_tag="DMA15_07950"
     CDS             889..1989
                     /NRPS_PKS="Domain: Aminotran_5 (17-286). E-value: 1.8e-28.
                     Score: 91.4. Matches aSDomain:
                     nrpspksdomains_DMA15_RS07965_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644018.1"
                     /locus_tag="DMA15_RS07965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07950"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_240660173.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.2e-21, bitscore:
                     75.7, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLSAQHFAAIEARVARLLDTEQDVVIMQGEALLPLE
                     GCIRGAARPGTTALNVITGPYGQTFGDWLRDCGADVVDLAVPFHTAVTADQVRQAFAEH
                     PEIDFVSLVHAEAATGNTNPVAEIGEVVREHGALFMLDAVASVGAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWQRIAANPQAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIETEGLDALMARHATAAAATRAGALALGGGLEPYVYEARDAAPVA
                     TTLRVPSGADASELVARALAADPVLPLVAGGGALAKEMIRVNHYGPDATRGVVHACLAA
                     LGAALTESGLTVDLEAARRAVTATWS"
     aSDomain        940..1746
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS07965_Aminotran_5.1"
                     /evalue="1.80E-28"
                     /label="DMA15_RS07965_Aminotran_5.1"
                     /locus_tag="DMA15_RS07965"
                     /protein_end="286"
                     /protein_start="17"
                     /score="91.4"
                     /tool="antismash"
                     /translation="AIEARVARLLDTEQDVVIMQGEALLPLEGCIRGAARPGTTALNVI
                     TGPYGQTFGDWLRDCGADVVDLAVPFHTAVTADQVRQAFAEHPEIDFVSLVHAEAATGN
                     TNPVAEIGEVVREHGALFMLDAVASVGAEPLLPDAWGVDLCVIGAQKAMGGPAGVSAVS
                     VSERAWQRIAANPQAPRRSYLSLLDWKERWIDGGRKALLHAPAQLEMLALEACVERIET
                     EGLDALMARHATAAAATRAGALALGGGLEPYVYEARDAAPVATTLRV"
     gene            2221..2671
                     /locus_tag="DMA15_RS07970"
                     /old_locus_tag="DMA15_07955"
                     /pseudo=""
     CDS             2221..2671
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016840.4"
                     /locus_tag="DMA15_RS07970"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07955"
                     /product="DinB family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHRATLALKCSGLDDEQALRTSVEPSSLSLFGLVQHLAEVERNWI
                     QRIFDQRDVPPIFEKSPDGGFTPDRDRTFAEVRGVGGRGRRQPEDMRGARAGRDGPARV
                     RGGGRRGRRGRGQPPLGPDPPHRGVRTPQRPRGSPARTHRRRDGKV"
     misc_feature    2864..2881
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.5"
                     /tool="antismash"
     misc_feature    complement(2866..2881)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: medium,
                     score: 17.62"
                     /tool="antismash"
     misc_feature    2876..2891
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     misc_feature    3025..3039
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.38"
                     /tool="antismash"
     gene            3048..3599
                     /gene="ectA"
                     /locus_tag="DMA15_RS07975"
                     /old_locus_tag="DMA15_07960"
     CDS             3048..3599
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013004616.1"
                     /locus_tag="DMA15_RS07975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07960"
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_125511958.1"
                     /transl_table=11
                     /translation="MTAAQADLPTDLQAKFPKMPEGLRLDSPAVADGAAIWRIARDSKV
                     LDLNSSYSYLLWCRDFAATSVVARDAAGEAVGFITGYIRPERPDTLMVWQVAVDHDQRG
                     RGLAGALLDGLTAKVAAGRALSTIETTIAPSNTASERLFLSYARRHGASVERRVLFDAG
                     LFPDDGHEPEVLYRIGPLGP"
     misc_feature    complement(3090..3104)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.91"
                     /tool="antismash"
     gene            3677..4948
                     /gene="ectB"
                     /locus_tag="DMA15_RS07980"
                     /old_locus_tag="DMA15_07965"
     CDS             3677..4948
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-365). E-value: 3.9e-74.
                     Score: 241.6. Matches aSDomain:
                     nrpspksdomains_DMA15_RS07980_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="DMA15_RS07980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07965"
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_125511960.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.4e-78, bitscore:
                     261.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRAQGSRMFDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYLERDGVVHGLDMSTTAKRAFLESFQNIILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYLDGQTPDFIWFERLLEDQGSGLNQPAAVIVETVQGEGGINVART
                     EWLRKLADVCERWDMLLIVDDIQMGCGRTGAFFSFEEAGITPDIVTVSKSISGYGMPMS
                     LCLFKPELDVWEPGEHNGTFRGNNPAFVTAAAALETYWTDGSAMEKQTRARGEQVEQAL
                     SAIVDENRAEIKEFRGRGLVWGIEFLDKDRASAVAKRAFELGLLIETSGPEGEVVKLLP
                     ALTITPDELDEGLRTLARAVRETA"
     aSDomain        3761..4771
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS07980_Aminotran_3.1"
                     /evalue="3.90E-74"
                     /label="DMA15_RS07980_Aminotran_3.1"
                     /locus_tag="DMA15_RS07980"
                     /protein_end="365"
                     /protein_start="28"
                     /score="241.6"
                     /tool="antismash"
                     /translation="FDRAQGSRMFDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYLE
                     RDGVVHGLDMSTTAKRAFLESFQNIILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYLDGQTPDFIWFER
                     LLEDQGSGLNQPAAVIVETVQGEGGINVARTEWLRKLADVCERWDMLLIVDDIQMGCGR
                     TGAFFSFEEAGITPDIVTVSKSISGYGMPMSLCLFKPELDVWEPGEHNGTFRGNNPAFV
                     TAAAALETYWTDGSAMEKQTRARGEQVEQALSAIVDENRAEIKEFRGRGLVWGIEF"
     gene            5001..5405
                     /locus_tag="DMA15_RS07985"
                     /old_locus_tag="DMA15_07970"
     CDS             5001..5405
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="DMA15_RS07985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07970"
                     /product="ectoine synthase"
                     /protein_id="WP_125511962.1"
                     /sec_met_domain="ectoine_synt (E-value: 2.3e-52, bitscore:
                     174.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAASGTWESKRIVLAKERVGFSLHETILY
                     AGTETSMWYANHIEAVVCTKGEAELTDDTTGEKYTITPGTMYLLDGHEKHTMRIKEDFH
                     CLCVFNPPVTGREDHDENGVYPLLTEPDPV"
     gene            5456..6355
                     /gene="thpD"
                     /locus_tag="DMA15_RS07990"
                     /old_locus_tag="DMA15_07975"
     CDS             5456..6355
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358305.1"
                     /locus_tag="DMA15_RS07990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07975"
                     /product="ectoine hydroxylase"
                     /protein_id="WP_125511964.1"
                     /sec_met_domain="PhyH (E-value: 1.2e-37, bitscore: 128.9,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPERTTDLYPTRGAEEVLIERKDPVVWSEPGAEGPIAAGDLA
                     GFERDGFLAIDQLITPDEVSVYHAELERLMNDPVMRADERAIVEPRSQEIRSLFEVHKI
                     SELFGRLAADPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLP
                     NMRTVSVSIALTKNHDTNGGLMIMPGSHKTFLGCAGATPKDNYKRSLQMQDAGIPSNET
                     LTHLAADHGIRLFTGEAGSATWFDCNAMHGSGDNITPYPRSNVFIVFNSVENKAVEPFA
                     APVRRPEFIGARDFTPVR"
     gene            complement(6422..7483)
                     /locus_tag="DMA15_RS07995"
                     /old_locus_tag="DMA15_07980"
     CDS             complement(6422..7483)
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003947424.1"
                     /locus_tag="DMA15_RS07995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07980"
                     /product="alkene reductase"
                     /protein_id="WP_125511965.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLSGTTLANRIAMAPMTRSRAGQGGVATDLTVAYYAQ
                     RASAGLIITEGIQPSVVGQGYPDTPGLHSAEQVASWRKVTDAVHAAGGKIFAQIMHAGR
                     IGHPVLLPDGLVNVAPSAVTAQGQVYTAEGPKDFVTPHELTDAEVRATIADFATAARHA
                     IDAGFDGVELHGANGYLIHQFLAPGTNRRTDEWGGSVENRLRFAVEVAKAVAAEIGAAR
                     TGFRLSPGNPFNDIAEPDPEPTYTALVKELAALDLAYLHVLEVGEIRELVTRLRQDFGG
                     TFILNPQTEGPTGQDALALVEDGTADIIAFGALFLANPDLPARLKAGGPYNTPDPTTFY
                     GGTEKGYTDYPAL"
     gene            7607..8131
                     /locus_tag="DMA15_RS08000"
                     /old_locus_tag="DMA15_07985"
     CDS             7607..8131
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643608.1"
                     /locus_tag="DMA15_RS08000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07985"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_125511966.1"
                     /transl_table=11
                     /translation="MKADPAPTDPAGPACPPGLPAVAMAGPASHAVSRVARLHRIAAGK
                     VLKGVGLYPGQEFVMMHLWEAGPVRQSELIKAVELDPSTVTKMLQRLEQAGHVRRRPDP
                     ADRRAVLVEASDASCGLLAQVERAWGELERHTLAGLDEDERAELLRLLAKVEENLCTET
                     AECPERRAAQG"
     gene            complement(8142..9200)
                     /locus_tag="DMA15_RS08005"
                     /old_locus_tag="DMA15_07990"
     CDS             complement(8142..9200)
                     /NRPS_PKS="Domain: Aminotran_5 (17-346). E-value: 2.7e-21.
                     Score: 67.8. Matches aSDomain:
                     nrpspksdomains_DMA15_RS08005_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156955.1"
                     /locus_tag="DMA15_RS08005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07990"
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_125517417.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.4e-15, bitscore:
                     53.9, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIGDGTDHAGEFAPTTTYLNTASCGLLPRRAVAAVQALAAEVGA
                     GERGGSGDFGKVEAARESFARLAGVAPSRVATGGSVAVHVGLIAASLPSGAEVLFPEGD
                     FSSLINPFVLRGDLKPRYAPLEGLAEAVRPETALVAFSTIQSADGREADCAAIRGAAAA
                     HGARTLADATQSAGWLPFDAGAYDYSVTGAFKWLLCPRGTSFLTVGEAAQESLLPLHGG
                     WLAAADSWHSTYGPIGELAPGARRFDEPPAFLAYHGAAAALSLIEEVGVDAIHAHDVAL
                     AERYRAGLAALGHSPVPGTSPIVSVPGLADREPELTRAGIIAAARAGHLRATFHLYNTE
                     ADVDRLLDVLAG"
     aSDomain        complement(8163..9149)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMA15_RS08005_Aminotran_5.1"
                     /evalue="2.70E-21"
                     /label="DMA15_RS08005_Aminotran_5.1"
                     /locus_tag="DMA15_RS08005"
                     /protein_end="346"
                     /protein_start="17"
                     /score="67.8"
                     /tool="antismash"
                     /translation="TYLNTASCGLLPRRAVAAVQALAAEVGAGERGGSGDFGKVEAARE
                     SFARLAGVAPSRVATGGSVAVHVGLIAASLPSGAEVLFPEGDFSSLINPFVLRGDLKPR
                     YAPLEGLAEAVRPETALVAFSTIQSADGREADCAAIRGAAAAHGARTLADATQSAGWLP
                     FDAGAYDYSVTGAFKWLLCPRGTSFLTVGEAAQESLLPLHGGWLAAADSWHSTYGPIGE
                     LAPGARRFDEPPAFLAYHGAAAALSLIEEVGVDAIHAHDVALAERYRAGLAALGHSPVP
                     GTSPIVSVPGLADREPELTRAGIIAAARAGHLRATFHLYNTEADVDRL"
     gene            complement(9232..9948)
                     /locus_tag="DMA15_RS08010"
                     /old_locus_tag="DMA15_07995"
     CDS             complement(9232..9948)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007381151.1"
                     /locus_tag="DMA15_RS08010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMA15_07995"
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_125511968.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHRDGVEVVHRSFELDP
                     GRAKGDSGPVIPMLMRKYGMTEEQAREGERRLGENAAAEGLDYLTEGRDHGNTFDMHRL
                     LHLAKERGRQDELIGLLYRANFAEERSVFEDDERVVELAVEAGLDGDEVRAVLADAEKY
                     ADEVRADEREAAELGANGVPFFVLDRKYGISGAQPAEVFTQALEQAWGSRSPLTALADA
                     DGGEACGPDGCAVPRG"
ORIGIN
        1 gatgttgacc agcgtcggga cgatggcgac cccccgctcg gcgaagagcg ggatggtgtc
       61 ctcggtgagg cccgtggcgt gttcgatgca gtcgatgccc gcctcgacca ggtcccgcag
      121 ggagtcctcg gcgaagcagt gggcggtgac gcgggcgccc aggcggtgcg cctcggcgat
      181 cgccgcctcc accgcgtccc gtggccagca ggcggtcagg tcaccggcct cgcggtcgat
      241 ccagtcgccg acgagcttga cccagccgtc gccgcgccgg gcctcctgtg ccacgtacgc
      301 gacgaggtcc tcgggttcga tctcatgggc gtagttgcgg atgtagcggc gcgtgcgcgc
      361 gatgtggcgg cccgcccgga tgatcttcgg caagtcctcg cggtcgtcga tccagcgggt
      421 gtcggacggc gagcccgcgt cacggatgag gagggcgccg atctcacggt cggtcagggc
      481 ctgcttctcg gccgtgtcgg cgtccacggg cccgtgggcg tcgagaccga cgtgacagtg
      541 cgcgtcgacc aggccgggca gcgcccagcc cgcgacggcg acggtctccg tcgcgggcgt
      601 caccgggcgg tcgtacgtca ccctcccccc gacgacccac agttcgtccc gtacgtcatc
      661 gggcccgacg agcacccgcc ccttcacgtg cagcaccgcg tgatcgctca tggcagcagc
      721 ttaggaggcg ctccgggcgg gcggtacggg gcgccgggaa cggcccgtga aggcgcggga
      781 gacggccggt gagggcactg ggcaggcccg tcaccgggtg ctcggtacgc tcgtacccgc
      841 agcccggacg aactcgtgag cgaagtgagc agtgacgtga gcagtactgt gacgcacccc
      901 tttctggacc tggcgccgct gagcgcccag cacttcgccg ccattgaggc gcgggtggcc
      961 cgtctgctcg acaccgagca ggacgtcgtg atcatgcagg gtgaggccct gctgcccctg
     1021 gaggggtgca tccggggcgc cgcgcggccc ggtacgaccg cgctgaacgt gatcaccggg
     1081 ccgtacgggc agaccttcgg cgactggctg cgggactgcg gcgccgacgt cgtcgacctc
     1141 gccgtgccct tccacacggc cgtcaccgcc gaccaggtgc gccaggcctt cgccgagcac
     1201 ccggagatcg acttcgtctc gcttgtgcac gccgaggccg ccaccggcaa caccaatccg
     1261 gtcgcggaga tcggcgaggt cgtgcgggag cacggcgccc tgttcatgct ggacgcggtc
     1321 gcctcggtgg gcgccgagcc gctgctgccc gacgcgtggg gcgtggacct gtgcgtgatc
     1381 ggcgcgcaga aggcgatggg cggtccggcg ggcgtctccg cggtgtcggt gagcgagcgg
     1441 gcgtggcagc ggatcgccgc caacccgcag gcgccccgcc gctcctatct ctccctcctc
     1501 gactggaagg agcgctggat cgacggcggc cgcaaggccc tgctgcacgc gcctgcccag
     1561 ctggagatgc tggccctgga ggcgtgcgtg gagcgcatcg agacggaggg cctggacgcc
     1621 ctgatggccc gccacgccac ggccgccgcc gccacgcgcg cgggggcgct cgcgctcggc
     1681 gggggcctgg agccgtacgt gtacgaggcc cgggacgcgg cccccgtcgc caccaccctg
     1741 cgcgtgccct cgggcgcgga cgcctcggag ctcgtcgcca gggcgctcgc cgcggacccg
     1801 gtgcttccgc tggtcgccgg gggcggggcg ctggccaagg agatgatccg ggtcaaccac
     1861 tacggcccgg acgccacccg gggtgtcgtc cacgcctgcc tcgcggccct cggcgccgcg
     1921 ctgaccgagt cgggcctgac ggtcgacctg gaggcggccc gccgcgcggt gacggccacc
     1981 tggagctagc ggccgctcgg acgcccggag ctagcggccg ctcggacgcc tggagtcggc
     2041 ggacaatcgg cgcccggagt cggcgggcga tcggggcggg gcggcccggg gccgaaagtc
     2101 caccctttcg ccgaggcgcc ccgccatggc aacgtgcccc tcatgagcac tctccccgac
     2161 ggccgccgca tcccgcccct gaccgccgac gagcccacca tgctggccag ttggctggac
     2221 atgcaccggg ccacgctcgc cctcaagtgc tcggggctcg acgacgagca ggcgctgcgc
     2281 acgtccgtgg agccgtcctc gctctccctg ttcggtcttg tgcagcacct cgccgaggtg
     2341 gaacggaact ggatccagcg gatcttcgac cagcgggacg tgcccccgat cttcgagaag
     2401 tcgccggacg gcgggttcac tccggaccgc gaccggacgt tcgccgaggt gcgcggtgtg
     2461 ggagggcgag gtcgccgtca accggaagat atgcgagggg cgcgcgccgg acgagacggg
     2521 ccggctcggg tccggggagg cggccgtcgt gggcggcgag gccgaggtca gcctccgctg
     2581 ggtcctgatc cacctcatcg aggagtacgc acgccacaac ggccacgcgg atctcctgcg
     2641 cgaacgcatc gacggcgtga cgggaaagtg agaggaacat gaatcgggcg cgcctttccg
     2701 gcaccggtca cgcatcttcc gtctatccgt ccgcctattc atccgcgcat tctcacgaat
     2761 tctttatcag cacagcttcc cgtattcttc tgcccgcttt ccggcatcct aaacactaag
     2821 gtttcgtcag cgccaatcgg cgtaattcgg acgcgtctca tgcaggttac atcggtgtga
     2881 cacactccac atcgcgccct tttcgcgggc atatgacccg gtcaaatcgc cacaaatcgc
     2941 ggagatctca cgcgtgcgca cacccacgcg cgataacaca tgaagcgcac ttgcggaacc
     3001 ccttccctcg atgcaattcc agaaattgct cggtaaattc aatccgcatg accgctgcac
     3061 aagccgatct accgaccgac ctgcaagcga aattcccgaa aatgcccgag ggactgcgac
     3121 tcgacagtcc cgctgtcgcc gacggcgccg ccatctggcg gatcgcccgc gactccaagg
     3181 tgctggacct caactcctcc tacagctacc tgctgtggtg ccgcgacttc gcggccacgt
     3241 ccgtcgtggc ccgggacgcc gccggcgagg cggtcgggtt catcaccggc tacatccggc
     3301 ccgagcgccc cgacaccctg atggtctggc aggtcgccgt cgaccacgat cagcgcggcc
     3361 gcggtctggc cggcgccctg ctcgacgggc tgaccgcgaa ggtcgccgcg ggccgcgcgc
     3421 tgagcacgat cgagacgacg atcgcgccct cgaacacggc gtccgagcgg ctcttcctct
     3481 cctacgcgcg tcgacacggc gcgtcggtgg agcgcagggt cctgttcgac gccgggctct
     3541 tccccgacga cggccacgag cccgaggtgc tgtaccgcat cggtccactc ggcccctgag
     3601 ccgccctcgc ttcccccagc cacacccgta actcccctac acctcccacg actttccatc
     3661 tcccaggaga tccgctgtga ccatcaccca gcccgacctg agcgtcttcg agaccctgga
     3721 gtcggaggtg cgcagctact gccgcggttg gcctacggtc ttcgaccgcg cgcagggcag
     3781 ccgcatgttc gacgaggacg gccacgagta cctcgacttc ttcgccgggg ccggctcact
     3841 caactacggc cacaacaacc cggtcctcaa acgcgcgctc atcgactacc tggagcgcga
     3901 cggcgtcgtg cacggtctcg acatgtcgac gaccgccaag cgcgccttcc tggagtcgtt
     3961 ccagaacatc atcctgcgcc cgcgcgacct gccgtacaag gtcatgttcc cgggcccgac
     4021 gggcaccaac gccgtggagt cggcgctgaa gctggcccgc aaggtcaagg gccgcgagtc
     4081 gatcgtgtcg ttcaccaacg ccttccacgg catgtcgctc ggctcgctcg ccgtgaccgg
     4141 caacgccttc aagcgggcgg gcgccggtat accgctggtg cacggcacgc cgatgccgtt
     4201 cgacaactac ctggacggtc agacgcccga cttcatctgg ttcgagcggc tcctggagga
     4261 ccagggctcc ggcctcaacc agcccgccgc cgtgatcgtc gagacggtgc agggcgaggg
     4321 cggcatcaac gtcgcccgca ccgagtggct gcgcaagctc gccgacgtgt gcgagcgctg
     4381 ggacatgctc ctgatcgtcg acgacatcca gatgggctgc ggccgcaccg gcgccttctt
     4441 ctccttcgag gaggcgggca tcacgccgga catcgtgacg gtgtcgaagt ccatcagcgg
     4501 ctacggcatg cccatgtcgc tctgcctgtt caagccggag ctggacgtgt gggagccggg
     4561 cgagcacaac ggcaccttcc gcggcaacaa cccggcgttc gtcacggccg ccgccgccct
     4621 ggagacgtac tggaccgacg gttcggcgat ggagaagcag acccgcgccc gcggcgagca
     4681 ggtcgagcag gcgctgagcg cgatcgtcga cgagaaccgc gccgagatca aggagttccg
     4741 cggccgcggt ctggtctggg gcatcgagtt cctcgacaag gaccgcgcga gcgccgtggc
     4801 gaagcgggcc ttcgaactgg gcctgctgat cgagacctcc ggccccgagg gcgaggtcgt
     4861 caagctcctc ccggcgctga cgatcacccc cgacgagctg gacgaggggc tgcgcacgct
     4921 ggcccgcgcg gtacgcgaga ccgcctgagc gagcgactgt ccgagccccg gcaacgtaag
     4981 agaaaaggaa ccaccacacc gtgatcgtcc gttcgttcaa ggacattgaa ggcaccgacc
     5041 ggcatgtgaa ggccgcttcg ggtacctggg agagcaagcg catcgtcctc gccaaggagc
     5101 gcgtggggtt ctccctgcac gagaccatcc tgtacgcggg gacggagacg tcgatgtggt
     5161 acgcgaacca catcgaggcc gtcgtctgca ccaagggcga ggccgagctg accgacgaca
     5221 cgaccggcga gaagtacacg atcaccccgg gcaccatgta cctgctcgac gggcacgaga
     5281 agcacaccat gcggatcaag gaggacttcc actgcctgtg tgtcttcaac ccgcccgtca
     5341 ccggtcgtga ggaccacgac gagaacggcg tgtacccgct gctcacggag ccggacccgg
     5401 tctgaacggc tgacatcccg cacagggccg tacgagagga gaggcaggca acaccatgac
     5461 caccgcaccc gaacgcacca ctgacctgta cccgacccga ggcgccgagg aggtgctcat
     5521 cgaacgcaag gacccggtgg tgtggtccga gccgggtgcc gaggggccca tcgcggccgg
     5581 ggatctggcg gggttcgagc gggacggttt cctggccatc gaccagttga tcaccccgga
     5641 cgaagtcagc gtgtaccacg ccgagttgga acggctcatg aacgacccgg tgatgcgggc
     5701 cgacgagcgt gccatcgtcg agccgcgctc acaggagatc cgctccctct tcgaggtgca
     5761 caagatcagt gagctgttcg gcaggctcgc cgccgatccg cgcgtggtgg gccgtgcccg
     5821 gcagatcctc ggctccgacg tgtacgtcca ccagtcccgg atcaacgtga agccgggctt
     5881 cggggcctcg gggttctact ggcactcgga cttcgagacc tggcacgcgg aggacggcct
     5941 gccgaacatg cgcaccgtct cggtgtcgat cgcgctgacg aagaaccacg acaccaacgg
     6001 cggcctcatg atcatgccgg ggtcgcacaa gacgttcctc gggtgtgcgg gcgccactcc
     6061 gaaggacaac tacaagcggt cgctgcagat gcaggacgcg ggcatcccgt cgaacgagac
     6121 gctgacccat ctcgcggccg accacgggat ccgcctcttc accggcgagg cgggctcggc
     6181 cacctggttc gactgcaacg ccatgcacgg ctccggggac aacatcaccc cgtatccgcg
     6241 ctctaacgtc ttcatcgtct tcaacagcgt ggagaacaag gcggtcgagc cgttcgcggc
     6301 gccggtgcgc aggcccgagt tcatcggggc gcgggacttc accccggtga ggtgacctga
     6361 cgtacacggc ggtcggcccg gcaccccccg tgggcgccgg gccgaccgcc gttctgccgt
     6421 gctacagcgc ggggtagtcc gtgtagccct tctcggtgcc gccgtagaag gtcgtcgggt
     6481 cgggggtgtt gtacgggccc ccggccttca ggcgggccgg caggtcgggg ttggcgagga
     6541 agagcgcgcc gaacgcgatg atgtccgcgg tgccgtcctc gacgagggcg agcgcgtcct
     6601 ggccggtggg gccctcggtc tgcgggttca ggatgaaggt gccgccgaag tcctggcgca
     6661 gccgggtgac cagctcgcgg atctcgccca cctccagcac gtgcagatac gcgaggtcca
     6721 gcgcggccag ctccttcacc agggcggtgt aggtgggctc cgggtcgggc tcggcgatgt
     6781 cgttgaaggg gttgccgggc gagaggcgga agccggtgcg ggcggcgccg atctccgcgg
     6841 cgacggcctt ggccacctcg acggcgaagc ggaggcggtt ctcgaccgag ccgccccact
     6901 cgtcggtgcg ccggttggtg ccgggcgcga ggaactggtg gatcagatag ccgttggcgc
     6961 cgtgcagctc gacgccgtcg aagcccgcgt cgatcgcgtg ccgcgcggcg gtggcgaagt
     7021 cggcgatggt ggcgcggacc tcggcatcgg tcagctcatg cggggtgacg aagtccttgg
     7081 ggccctcggc cgtgtagacc tgcccctggg cggtgaccgc cgagggggcg acgttgacca
     7141 ggccgtcggg gagcaggacg gggtggccga tgcgcccggc gtgcatgatc tgggcgaaga
     7201 tcttgccgcc cgccgcgtgc acggcgtcgg tgaccttgcg ccaggaggcg acctgctcgg
     7261 cgctgtgcag gcccggcgtg tccgggtatc cctggccgac cacagaaggc tggatgccct
     7321 cggtgatgat caggcccgcg gaagcgcgct gggcgtagta cgccacggtc agatcagtgg
     7381 ccacaccgcc ctgaccagcg cgactacggg tcatgggggc catggcgatg cggttggcga
     7441 gcgtggtgcc ggacaggtcg atcggatcga acgcggtggt catcagaact cctgggcaag
     7501 ttttatgtgg tcggccaagt aacgcgccgg gtcttactgt aacccatttc ttggccgacc
     7561 aaggtaatct tttcggaaga cgtccagtga ccagcaggag cacgcgatga aggccgaccc
     7621 cgcaccgacc gacccggccg gccccgcctg tcctcccggg ctgcccgcgg tggccatggc
     7681 gggccccgcg agccacgcgg tcagccgggt ggcgcggttg caccgcatcg ccgcgggaaa
     7741 ggtcctgaag ggggtcggcc tctaccccgg ccaggagttc gtgatgatgc acctgtggga
     7801 ggcgggcccg gtgcggcagt ccgagctgat caaggcggtg gagctggacc cctcgacggt
     7861 cacgaagatg ctccagcggc tggagcaggc gggccatgtg cgccgccgcc ccgaccccgc
     7921 cgaccgccgg gccgtcctcg tcgaggccag cgacgcgagc tgcgggctgc tcgcccaagt
     7981 ggagcgcgcc tggggcgagt tggagcggca tacgctcgcc gggctcgacg aggacgagcg
     8041 tgcggaactg ctgcggctgc tcgccaaggt ggaggagaac ctctgcacgg agacggcgga
     8101 gtgcccggag cggcgggccg cgcaagggta ggcgtgccgg ctcagccggc cagtacgtcg
     8161 aggaggcggt ccacgtcggc ctcggtgttg tacaggtgga aggtggcgcg cagatggccc
     8221 gcccgcgccg ccgcgatgat gcccgcgcgg gtcagttccg gctcgcggtc ggcgagcccg
     8281 gggaccgaga cgatgggcga ggttcccggc accggggagt ggccgagtgc ggcgagcccc
     8341 gcgcggtagc gctcggcgag cgccacgtcg tgggcgtgga tcgcgtcgac gcccacctcc
     8401 tcgatcaggg agagcgccgc ggccgccccg tggtaggcga ggaaggcggg cggctcgtcg
     8461 aacctccgcg cgcccggggc gagttcaccg atcgggccgt acgtcgaatg ccaggagtcg
     8521 gccgccgcga gccagccgcc gtgcagtggc agcagggact cctgcgccgc ctcgcccacc
     8581 gtcaggaaag acgtgccgcg cgggcagagc agccacttga aggcgccggt gacggagtag
     8641 tcgtacgccc ccgcgtcgaa cggcagccag cccgccgact gtgtggcgtc ggcgagggtg
     8701 cgtgcgccgt gcgcggccgc ggccccgcgg atcgcggcgc agtccgcctc gcggccgtcg
     8761 gcggattgaa tggtggagaa cgcgaccagc gcggtctcgg gccggaccgc ctccgcgagc
     8821 ccctccagcg gcgcgtaccg cggcttcagg tcgccccgca gcacgaaggg gttgatcagg
     8881 gacgagaagt ccccttcggg gaagagcact tcggcgcccg acgggaggga ggcggcgatc
     8941 aggccgacgt gcacggcgac cgagccgccg gtcgccaccc gcgagggcgc cacacccgcc
     9001 agccgcgcga aggactcgcg ggccgcttcg accttgccga agtcgcccga gccgccgcgc
     9061 tcgcccgcgc cgacctccgc cgccagggcc tggacggccg cgacggcccg gcgcggcagc
     9121 agaccgcagc tcgccgtgtt gaggtaggtc gtcgtcgggg cgaactcgcc cgcgtggtca
     9181 gtgccgtcgc cgatccccat gagcgtcatg gggatcaacc tatgcggccg ctcagccccg
     9241 cggaaccgcg catccgtcgg gcccgcacgc ctcgcccccg tcggcgtccg cgagggcggt
     9301 cagcggtgaa cggctgcccc acgcctgctc gagcgcctgc gtgaagacct cggcgggctg
     9361 ggcgccggag atgccgtact tgcggtcgag gacgaagaac ggcacgccgt tcgcgcccag
     9421 ctcggcggcc tcgcgctcgt cggcgcggac ctcgtcggcg tacttctcgg cgtcggcgag
     9481 tacggcacgc acctcgtcgc cgtccaggcc cgcctcgacg gccagctcca cgacgcgctc
     9541 gtcgtcctcg aagacggacc gctcctcggc gaagttcgcg cggtagagca ggccgatcag
     9601 ctcgtcctgc cggccccgct ccttggcgag gtgcaggagg cggtgcatgt cgaaggtgtt
     9661 gccgtggtcg cggccctcgg tgaggtagtc gaggccctcg gcggcggcgt tctccccgag
     9721 ccgccgctcg ccctcgcggg cctgctcctc ggtcatgccg tacttgcgca tgagcatcgg
     9781 gatgacgggg ccgctgtcgc ccttggcgcg gcccgggtcc agttcgaagg agcggtgcac
     9841 gacctcgacg ccgtcgcggt gcgggaaggc ggcgagggcc ttctcgaagc gggccttgcc
     9901 cacgtagcac caggggcagg cgatgtcgct ccagatctcg acgcgcatgt gtgtggctct
     9961 cttcaggtcg tacgtcaggt cggtgcggag ggagcctccg ctcagggcgt caacacacgg
    10021 gcaaagcggc tcattccccc gccgcgaact tccccgtgtt ggccctgacc caggtgcgca
    10081 ggtgcgccag tggctccagg gcgccccggc cgaggccggt cagttcgtac tcgacgcggg
    10141 gcgggacctc cgcgtagacc gtccgtttca cgaggccgtg ttcctccagg cggcgcaggg
    10201 tctgcgtgag cgccttgggg ctgacgccct ccagcttgcg gcgcagctcg ccgaagcggc
    10261 gcgggccgtc ctccagggcg gtgatggcga ggcccgtcca cttgtggacg aggagttcgt
    10321 agaccgcgcg gccggggcag agcaggccgt agatgtcgtg gggccgagca gcggtgccgg
    10381 aggtcctgtc gcggggctga ccagt
//
