LOCUS       NZ_CP029618            11380 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 06738 chromosome, complete genome.
ACCESSION   NZ_CP029618
VERSION     NZ_CP029618.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 06738
  ORGANISM  Streptomyces sp. WAC 06738
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8324535)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8324535)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. Jun-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 148.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945505.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 05:01:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,191
            CDSs (total)                      :: 7,115
            Genes (coding)                    :: 6,917
            CDSs (with protein)               :: 6,917
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 107 of 198
            Pseudo Genes (incomplete)         :: 115 of 198
            Pseudo Genes (internal stop)      :: 5 of 198
            Pseudo Genes (multiple problems)  :: 27 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:28:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7111149
            Orig. end                         :: 7122529
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029618.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11380
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="20"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11380
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11380
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6380](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6380)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(854..870)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 14.0"
                     /tool="antismash"
     gene            complement(1339..3060)
                     /locus_tag="DMB38_RS31005"
                     /old_locus_tag="DMB38_30990"
     CDS             complement(1339..3060)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004120.1"
                     /locus_tag="DMB38_RS31005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_30990"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_125937919.1"
                     /transl_table=11
                     /translation="MMLHPELLRAARTAPGPLSGATALLAAVTAAHVAQAALLAAALAD
                     IACGRDDRLPALLGAVVAVVALRALLTWRQRIAAADAGARIRLRLRDELVARLGRLGPA
                     HRSAARAGALRATVVDGVEGVNAYLSRYLPQLAVVGLATPALLVWVAVLNPAAAAVLTA
                     AVALALLAPRLWDRALAGRGKEHWDTYEHLAADYLEALQHMPALRAAGAVGSKRAALEE
                     RSGQVHRATVAKLRVSLVDTALTDLAIQAGTLAAVLLACTSAATGAAAGGETYLLLMLT
                     SECFRPLRDLSREWHAGYLGVSAADGIAALRTARPATPDNGTLHPAWTSAPALTFADVT
                     FTYPGAARPAVDGVTFTCEAGRTTALVGPSGAGKTTLLALLQRQHDPDTGAVLLDGTDI
                     RDLALDALRRGIAVVSQDTYLFHASVADNLRLARPGASDDELAAACRDAGVHDEIATLP
                     GGYATVLGERGATLSGGQRQRLALARALLADAPVLILDEATSAVDEARESLITEALRQA
                     TQGRTCLVVAHRLAAVRHADRVVVLDHGRLDAVGDHRSLAGAGGTYAELVAADLRS"
     gene            complement(3057..4991)
                     /locus_tag="DMB38_RS31010"
                     /old_locus_tag="DMB38_30995"
     CDS             complement(3057..4991)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015508299.1"
                     /locus_tag="DMB38_RS31010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_30995"
                     /product="hypothetical protein"
                     /protein_id="WP_125937920.1"
                     /transl_table=11
                     /translation="MTTSSTARAGAPGAGGPEPEPAEQGPGVRPDAAGTRANARLVAAA
                     LADARSGRPVEPDTPSGPARQRWREPARRVPAAGAGDVDLDTVLTLSLAAGKPARAGTS
                     GGNAAPAHGTPGAATAGLHTGRAAARPRAAASAGGRYPVRAHLLVGPGCPLPPGRYAYD
                     PLTHRVHRRGPAPGNAARGVVAVLTVAAQRTVSHYGHRAWPLLLLDTGHAAAALALASV
                     GTGHAARVCLDADGALLAAAAGLPPPGSWRDLWPGTSPEHPLAAVHIRPGAAGPGTSGI
                     PPAAAETGTYDAPPGPAGAPDGDVCPLAAWAAVRLPAPPGAGPAAGSPVGRRTAAVLGA
                     LTRAPHAGDRPAWWRARPPWQGGRVEPPCAQGALPAALRRRRSAFPPLAGEPERTALAA
                     VLHAAAAACPSGPAWCAAVGGRNPGLLAPAGGAGTGVVSPAAGDRDHTDRNLGDRRPDS
                     HGAGGDEALLVPGRAGPGSRPDRPEEPGGHAVREEARPYEGAAPAPPLRLMARGEARPA
                     LAAWAAGQGWLAGAGAVLLARSAPGDASPAGVRAVHLAAGYAAASAEVTAAALGLRSRP
                     VGSWQRADLGAALGDARGERWVVHGLALAAPEDAAQVGRKGPVPASPAQAAAGTSATPD
                     PNTAGNERR"
     gene            complement(5001..6380)
                     /locus_tag="DMB38_RS31015"
                     /old_locus_tag="DMB38_31000"
     CDS             complement(5001..6380)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059075.1"
                     /locus_tag="DMB38_RS31015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_31000"
                     /product="YcaO-like family protein"
                     /protein_id="WP_125937921.1"
                     /sec_met_domain="YcaO (E-value: 1.2e-43, bitscore: 148.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPPLPLDALVDPVCGLVRSVAPVPHPPGTPARYTAMTADVSDAR
                     RLGAWPADRVALGTTFGDPDGARVAAVAEAVERYCGNRVPPAGEPGAPLRTTAARLVAE
                     GRALLTPGELPSYADWQYGRPRFPYRPLTPATETLWARGRERLPGGGERDCWAPVALTH
                     LNWRQGELTGLPRTHHLNYAGIATGRGRADAAERALLEVVERDALELWWHLGGPARGID
                     LATVPGLAADLEGSPLRAWVVEMPGDFAPAMAALVHDAERGLYAAGFACRHDPAEAARK
                     AVLEAVHTWVFTQGLTEPDGWVFRAIEAGMLARGLYLDHRTDRRYLDDAGEDFARVRDL
                     GAHVQVWLDDRLAPLARRFTDPAETVPIGAVAPGSPGLLHRRLAEGGHRVVTFDLTTPD
                     VAETALRVTRVLVTGLVPNAPAAFAYYGCPRFADAAVARGWRTEPPAGPADFTLAPPPH
                     M"
     gene            complement(6377..7954)
                     /locus_tag="DMB38_RS31020"
                     /old_locus_tag="DMB38_31005"
     CDS             complement(6377..7954)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012377868.1"
                     /locus_tag="DMB38_RS31020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_31005"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_125937922.1"
                     /transl_table=11
                     /translation="MSTTASGPALCHADVPVPDGTVLATDYCLPAGAGPFPAVLVRTPY
                     GRVAHHAELRAWARHGFAAVAQDVRGRHGSTGTWRPYLHEAADGAVVLRWLRSRPWSDG
                     RVVACGTSYAAHAALATALEPPEGHVGPPDPPDPPDAVIAAVPALGLAETARERGGVER
                     LYARAGWWAAHGDRRDSDPGALDRALAADPRLLEHLPLLDLPRRLGRPLPAWPLLWDAA
                     SADVAGRARDARTPLLAVGGTHDPFAADTVRLWRAWGVRTGAAARLLLGPWGHGLTAQP
                     GPGARPAHRIGLGALYVRFARAALAGRLRGRRGAAGVGDSDAWLDATRFPSATAVPLNG
                     GPWGMRTVRGAAFTADVARPVRSDRLDVPTGGVPDRCLIVSAPLPAGLHLAGSAEARIE
                     GTADTPTADWAVRLTALTADDTAHPLAAGVARREHDGPGQTCRIRVELGPLARRLAAGT
                     RLRVEVAGHHFPAHARNPHTGQDPVRATALRPSRRTVVTAGCRLLLPVLGASAAAARSV
                     DPAEETTR"
     gene            complement(7951..8922)
                     /locus_tag="DMB38_RS31025"
                     /old_locus_tag="DMB38_31010"
     CDS             complement(7951..8922)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010072943.1"
                     /locus_tag="DMB38_RS31025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_31010"
                     /product="hypothetical protein"
                     /protein_id="WP_125939394.1"
                     /transl_table=11
                     /translation="MPRPRLAPGVDVFDVPGRPTAVRTPDGEFLHVDAEPGAVARLLAE
                     LDGTAGARPGGPAAADEEARRLLTAFADAGYLDPPAVWPAERAGVLLLGDAELTGPLAG
                     LLSAAGARPRAGTPEEVAALAAGRLRGGPATGGVSVTAPTAAPVAAVVWCLDRPVPAGL
                     WDAADRLPARGIAWARSHREGLQAWVEPLAAGAGDVLARHVRARRLAATPAHRELAAYW
                     GAASATGPCPGGTAAGAAFVAALLATDLTAWATAGVRTGRSPGGAGLPASRRLRRLDLR
                     DLSVSEHPVLPVPAVAPLPTAPEGAPGAVPAPARPAGPARIA"
     gene            complement(9034..9150)
                     /gene="amiA"
                     /locus_tag="DMB38_RS37290"
     CDS             complement(9034..9150)
                     /codon_start=1
                     /gene="amiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004004115.1"
                     /locus_tag="DMB38_RS37290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="streptamidine family RiPP"
                     /protein_id="WP_240662558.1"
                     /transl_table=11
                     /translation="MEQEQPVFKPVEEPGQLAHLSATHSNALVENPFDDEQE"
     misc_feature    9201..9216
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 14.14"
                     /tool="antismash"
     misc_feature    complement(9202..9218)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 13.54"
                     /tool="antismash"
     misc_feature    9204..9217
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.3"
                     /tool="antismash"
     misc_feature    complement(9204..9219)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.89"
                     /tool="antismash"
     gene            complement(9205..10005)
                     /locus_tag="DMB38_RS31030"
                     /old_locus_tag="DMB38_31015"
     CDS             complement(9205..10005)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010639452.1"
                     /locus_tag="DMB38_RS31030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_31015"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_240662785.1"
                     /transl_table=11
                     /translation="MEADRLGFGYPGRRVLDGVSLTVRPGELVALVGLNGCGKSTLLRL
                     AAGMLRPDAGRIRVAGADVSRLPRRAAARRVALLHQSAPAVPGMTVRQLVRQGRYAARG
                     PLGMLRDGDDAVSLRAMADVGVDGWADRPVDALSGGERQRVRLALALAQDAPLLLLDEP
                     TTYLDLRHQLEVLQSVTRLRSERRMTVLMVLHDLGLAARFSERLVALRDGRVAADGRPQ
                     DVVTPELLREVFGVEGRVGRDPVHGWPVCYPDTPTPLAYENHIH"
     gene            complement(10139..11167)
                     /locus_tag="DMB38_RS31035"
                     /old_locus_tag="DMB38_31020"
     CDS             complement(10139..11167)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059070.1"
                     /locus_tag="DMB38_RS31035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_31020"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_125937924.1"
                     /transl_table=11
                     /translation="MKARTAYGPRLVLGGLTAAVLVAAVAGLLAGGAVAPGEVWPALTG
                     GDVDPTTRHVVWRLRVPRVLVALVAGACLGLAGLVLQAALRNPLAGPEVTGVTPGAVLG
                     AVAASGAGLAGWDSPTAVVVAAVAGGCAGAGLLWLLAGRDRADPAAVAVHGVLVSAVLG
                     GLTAMVLLVAPGELGSVVQWLVGTTEARTWEHWALLWPWALAWGAAAWLTAGPLMLLRC
                     GEDVARAAGLASSRARVLALVCAVGLTAGAVAAVGALGFVGLLVPHVALALLGADLRLA
                     LPGAALAGAVAVCGADAAAQLASRAAVSWGAERLSIPVGAVTTAVGAAVLLVVARRHTT
                     EL"
ORIGIN
        1 ggcgtcgcgc aggtgccggt ccggcaggtg gcgtacgtcg acggggtcgc cgccgtcggc
       61 ggggaggagt tcgacggtgc ccgagcgggg atcccagaag cgggccagca ggtgggccgt
      121 gctggtcttg cccgcgccgg aggcgccgac cagggcgagc gtgcagccgg ccggcacggt
      181 caggtccaca ccgcgcagga cgggcccggc gccgtagtcg acgtggacgt tccgcagtcg
      241 cacgccgagc gggccgggcg gcagcggccg ggggtgcgtc ggcggtgggg cgcccgcggg
      301 ggcggaggtg gcggcgtgga cgcgggccgc cgcggcgcgc agggtgccgg cctggcgcag
      361 ggcgtcggcg gcggcggcca cgggagagag cacggacagg gcgagggcca gggcggcggg
      421 tgcccacgcg ccgtgcagcc ggccgtcgcc ggtggtggcg gctccggccg cgaggacgcc
      481 gacgagggcg aggacgacca gcatgtcctg gacggcggcg aaggcgccct cgtgcccggc
      541 ctcggcgcgc tgggcgtcgg tgagccggcg cccgctcgcg gtgagctccg cgcgccgccg
      601 gtccagggcg ccgtgggcca ggagttcgcg cagaccgtcg acggtgtcca cggcgtcggc
      661 ggagagccgc gcggtcgcgg ccctggtgat ctccccgcgc gccgtgcggc ccgcggttcc
      721 gaggagcgag tgcgccagga gtgccgccgc ggcggcgagt gcggcgatca gcagccaggg
      781 gtcgaggagg ccgagtacgg ccgcccccgc ggcgaagacc acggcggagg cgaggagttg
      841 ggcgatggtg tgggcgtaga agaactccag ggcctcgatg tcgttcatgg cggtggcggc
      901 caggtccccg ctgcggcgcc ccgcgatccg ggcgggggcg ctgcgggcca gtccgtcgta
      961 gacacggaca cggagccggg ccaggacgcg gtaggcgagg tcgtgggaga ggtccatctg
     1021 ccgccaggtg gcgaacgcgc gcagcagcac gagcgcggtg agggcgccga tggtggcgcc
     1081 gtccgggccg gtgccgtcga tgacggcgcg cccggtggcg tacgcgagcc aggtgacgag
     1141 cacgacgagg caggtctggt cggccaggca ggcgacggcg gtacgcgccg ccatggcccg
     1201 gtgcgggcgc agggcgggca gcaggcggcg cagcgccccc cgcgcgggcg ccggcgggcg
     1261 gctgtgcggg ggtgcggtgt gggtcgaccg ggtgtccgtc gccggctggg gcgtcatggt
     1321 ttctttctcc cgttccggtc aggaccgcag gtcggcggcg acgagttcgg cgtacgtgcc
     1381 cccggccccg gccaggctgc ggtggtcgcc gaccgcgtcc agacggccgt ggtcgagcac
     1441 gacgacgcgg tcggcgtgcc gtaccgcggc gagccggtgg gcgacgacca ggcaggtgcg
     1501 gccctgcgtg gcctgccgca gggcctcggt gatgaggctc tcgcgggcct cgtcgacggc
     1561 gctggtggcc tcgtccagga tcagcacggg tgcgtccgcg agcagtgcgc gcgccagggc
     1621 gagccgctgg cgctggccgc cggagagggt cgcgccgcgc tcgccgagca cggtggcgta
     1681 ccccccgggc agcgtcgcga tctcgtcgtg gacgcccgcg tcgcggcacg cggcggccag
     1741 ttcgtcgtcg ctcgcgccgg gacgggccag gcgcaggttg tccgcgacgg aggcgtggaa
     1801 gaggtacgtg tcctgcgaga cgacggcgat accgcggcgc agcgcgtcca gtgccaggtc
     1861 gcggatgtcg gtgccgtcca gcagcacggc gccggtgtcg gggtcgtgct gccgttgcag
     1921 cagtgcgagc agggtggtct tgcccgcccc cgacgggccg accaaggcgg tggtgcgccc
     1981 ggcctcgcag gtgaaggtga ccccgtccac ggcaggccgg gcggcgccgg ggtaggtgaa
     2041 cgtcacgtcg gcgaaggtca gggcaggcgc cgacgtccag gccgggtgca gtgtcccgtt
     2101 gtcgggtgtg gcgggccggg cggtgcgcag ggcggcgatg ccgtcggcgg cggagacgcc
     2161 gaggtagccg gcgtgccact cgcgcgacag gtcgcgcagc ggccggaagc actcggaggt
     2221 gagcatcagc agcaggtacg tctcaccccc ggcggcggca ccggtggcgg cggaggtgca
     2281 ggccagcagg acggcggcga gcgtgcccgc ctggatggcc aggtcggtga gcgcggtgtc
     2341 caccagggag acgcggagct tggcgaccgt ggcccggtgc acctgcccgg accgttcttc
     2401 cagcgcggcg cgcttgctgc ccaccgcccc cgcggcgcgc agcgccggca tgtgctgcag
     2461 cgcctccagg tagtcggcgg ccaggtgctc gtaggtgtcc cagtgctcct tgccgcggcc
     2521 cgccagcgca cggtcccaca gccgcggggc gagcagggcc agcgcgacgg cggcggtgag
     2581 tacggctgcc gcggcggggt tcaggacggc cacccagacc agcagcgcgg gggtggccag
     2641 gccgacgacg gcgagctggg gcaggtagcg ggagaggtag gcgttgacac cctccacgcc
     2701 gtccaccacg gtggcgcgca gcgccccggc ccgtgcggcg gaccggtggg cggggccgag
     2761 ccgcccgagt cgcgcgacca gctcgtcgcg gagccgcagc cggatcctgg ccccggcgtc
     2821 cgccgcggcg atccgctgcc gccaggtcag cagcgcgcgc agcgcgacga cggcgacgac
     2881 cgcgccgagc agggccggca gccggtcgtc cctgccgcag gcgatgtcgg cgagcgccgc
     2941 cgccaggagc gcggcctgcg cgacgtgggc ggcggtgacg gcggcgagca gcgcggtggc
     3001 gcccgacagc gggccggggg cggtacgggc ggcgcgcagc agctcggggt ggagcatcat
     3061 cggcgttcgt tccctgcggt gttcggatcg ggagtggctg aggtgcccgc cgctgcctgc
     3121 gcgggtgagg ccggtacggg acctttgcgc cccacctgcg cggcgtcctc gggcgcggcc
     3181 agtgcgaggc cgtggacgac ccaccgctcg ccccgggcgt cgccgagcgc cgcgcccagg
     3241 tccgcccgct gccaggagcc gacgggccgg ctgcgcaacc cgagtgcggc cgcggtcact
     3301 tcggcggagg cggccgcgta cccggcggcc aggtgcacgg cgcgcacacc ggcgggcgat
     3361 gcgtcgcccg gggcgctacg ggcgagaaga acggccccgg caccggcgag ccagccctgc
     3421 ccggccgccc aggcggcgag cgcggggcgc gcctcgccgc gggccatcag acgcaacggc
     3481 ggggcgggcg cggcgccctc gtacgggcgc gcttcctccc gtacggcatg gccgcccggc
     3541 tcctcggggc ggtccgggcg cgaaccgggg ccggcgcggc cgggcacaag caaggcttca
     3601 tccccgcccg caccgtggct gtccgggcgc cggtcgccga ggttccggtc cgtgtggtcg
     3661 cggtcgcccg ccgcggggga gacgacgccc gttccggcgc cgccggccgg ggccagcagg
     3721 cccgggttcc ggccgccgac cgcggcacac caggcgggcc cggaggggca ggcggccgcg
     3781 gccgcgtgca gcacggcggc cagcgcggtc cgttccggct ctccggcgag cggcgggaac
     3841 gcgctgcgcc ggcgtcgaag ggcggccggc aaggcgccct gcgcgcaggg cggttcgacg
     3901 cgaccgccct gccacggcgg acgggcccgc caccaggccg gccggtcccc tgcatgaggg
     3961 gcgcgggtga gcgcgcccag tacggccgcg gtacggcggc cgaccggact gcccgccgcc
     4021 ggcccggccc cgggtggcgc cgggagccga accgcagccc acgcggcgag cggacacacg
     4081 tcgccgtccg gggccccggc aggccctggc ggcgcgtcgt acgtgccggt ttccgccgcc
     4141 gcgggcggga tgccggatgt ccccggtccc gccgctccgg ggcggatgtg gacggcggcg
     4201 agcgggtgtt ccggcgacgt accgggccac aggtcccgcc agctcccggg cgggggcagg
     4261 cccgccgccg cggccagcag cgccccgtcc gcgtccaggc acacccgcgc cgcgtgaccc
     4321 gtgcccaccg atgccagcgc gagcgcggcg gcggcatggc cggtgtccag cagcagcaac
     4381 ggccaggccc ggtggccgta gtgggagacg gtgcgctgcg cggccaccgt gaggacggcg
     4441 acgacgcccc gggcggcgtt gccgggagcc ggaccgcggc ggtggacccg atgggtcagc
     4501 gggtcgtacg cgtagcgccc cggcgggagc gggcagccgg ggccgacgag caggtgggcg
     4561 cggaccgggt agcggcctcc ggccgaggcg gcggcacgcg gcctggcggc cgcgcggccg
     4621 gtgtggaggc cggcggtggc cgcgcccgga gtgccgtgcg cgggagcggc gttgccgccg
     4681 gaggtcccgg cgcgggccgg cttgcccgcg gcgagggaca gggtgagcac ggtgtcgagg
     4741 tcgacgtccc ccgctccggc agcgggcacg cggcgggcgg gctcccgcca gcgctgccgg
     4801 gcgggaccgg aaggggtgtc gggctcgacg gggcggccgg agcgggcgtc ggcgagggcg
     4861 gcggcgacga gccgggcgtt cgcacgtgtt ccggcggcgt ccggccgtac cccggggcct
     4921 tgttccgccg gctccggttc cgggccgccc gcgccggggg cgcctgcccg ggcggtggaa
     4981 gaggtggtca tccggtttcc tcacatgtgc gggggcgggg cgagcgtgaa gtcggccggt
     5041 cccgccgggg gttcggtgcg ccagccgcgg gccacggcgg cgtccgcgaa ccgcgggcag
     5101 ccgtagtacg cgaaggcggc gggcgcgttc ggcaccaggc ccgtgaccag gacacgggtc
     5161 acgcgcagcg ccgtctccgc cacgtcgggc gtggtcaggt cgaaggtcac cacgcggtgt
     5221 ccgccctcgg cgaggcgccg gtgcagcagc ccgggagagc cgggggcgac ggcgccgatc
     5281 gggacggtct ccgcggggtc ggtgaaccgc cgtgccagcg gggcgagccg gtcgtccagc
     5341 cacacctgga cgtgcgcgcc gaggtcacgt acgcgggcga agtcctcgcc tgcgtcgtcg
     5401 aggtagcggc ggtcggtgcg gtggtcgagg tagagcccgc gggcgagcat gccggcctcg
     5461 atcgcgcgga agacccagcc gtccggttcg gtgagtccct gggtgaagac ccaggtgtgg
     5521 acggcctcca ggacggcttt gcgggcggcc tctgccgggt cgtggcggca ggcgaacccg
     5581 gccgcgtaca ggccgcgttc ggcatcgtgg acgagggcgg ccatggcggg ggcgaagtcg
     5641 cccggcatct ccaccaccca ggcccgcagc ggcgagccct ccaggtccgc ggcgaggccc
     5701 gggaccgtgg ccaggtcgat gccgcgggcc gggccgccga gatgccacca cagttcgagg
     5761 gcatcgcgtt cgacgacttc gagcagcgcg cgctcggcgg cgtccgcccg tccccggccg
     5821 gtggcgatgc cggcgtagtt gaggtggtgg gtgcggggca ggccggtcag ttcgccctgg
     5881 cgccagttga ggtgggtgag cgccaccggc gcccagcagt cgcgttcccc gccgccgggc
     5941 agccgttcgc gcccgcgggc ccacagcgtc tcggtggccg gtgtgagcgg ccggtagggg
     6001 aagcggggcc ggccgtactg ccagtccgcg tacgacggga gttcgccggg ggtgagaagt
     6061 gcccggcctt cggcgacgag gcgggcggcg gtggtacgca ggggggcacc gggctcgccg
     6121 gccgggggga cgcggttgcc gcagtagcgc tcgacggcct cggcgacggc ggcgacgcgg
     6181 gcgccgtccg ggtcgccgaa cgtggtgccg agcgcgacgc ggtcggcggg ccaggcgccg
     6241 aggcggcggg cgtcggagac gtcggcggtc atcgccgtgt agcgggcggg ggtgccgggc
     6301 ggatgcggta cgggggcgac ggagcggacc aggccgcaga ccgggtcgac gagtgcgtcc
     6361 agcggcagcg gcgggttcac cgggttgtct cctcggccgg gtcgacggaa cgggcagcgg
     6421 cggcggatgc gccgagtacg ggcagcagca ggcggcagcc cgcggtgacg acggtccgcc
     6481 gggacgggcg cagagcggtg gcgcgtacgg ggtcctggcc ggtgtgcgga ttgcgggcgt
     6541 gggcggggaa gtggtggccg gcgacttcga cgcgcagccg ggtgccggca gccagccggc
     6601 gtgcgagcgg gccgagttcg acgcggatgc ggcaggtctg cccggggccg tcgtgctcgc
     6661 ggcgggcgac tccggcggcc agggggtgtg ccgtgtcgtc ggcggtgagc gcggtgagac
     6721 ggacggccca gtcggcggtg ggcgtgtccg cggtgccctc gatacgggct tccgcgctcc
     6781 cggcgaggtg gaggccggca ggcagcggcg cggagacgat caggcagcgg tcgggcacgc
     6841 cgccggtggg cacgtcgagg cggtcggagc gcaccggccg ggcgacgtcg gcggtgaagg
     6901 cggcgccccg tacggtccgc atgccccagg gcccgccgtt cagcggtacg gccgtggcgg
     6961 agggaaagcg cgtggcgtcg agccaggcgt cgctgtcgcc gacccccgcc gcgccgcggc
     7021 ggccacgcag ccttcccgcg agggcggcgc gggcgaaccg cacgtagagg gcgccgagtc
     7081 cgatgcggtg ggcggggcgg gcaccggggc ccggctgtgc ggtgaggccg tggccccacg
     7141 ggccgaggag gagccgggcc gcggccccgg tccgtacgcc ccaggcccgc cagagccgta
     7201 cggtgtcggc cgcgaaggga tcgtgggtgc cgccgacggc gagcagcggc gtccgggcgt
     7261 cgcgggcacg gccggcgacg tcggcggagg cggcgtccca cagcagcggc caggcgggca
     7321 gcgggcggcc gagacggcgc gggaggtcga gcagcggcag gtgctccagg aggcgggggt
     7381 cggcggccag cgcccggtcg agggcgcccg ggtcgctgtc gcggcggtcg ccgtgcgccg
     7441 cccaccagcc ggcccgggcg tacagccgtt ccacgccgcc gcgttcgcgg gcggtctcgg
     7501 ccagaccgag cgcggggacg gcggcgatga cggcgtcggg cggatccggc gggtccggcg
     7561 gccccacgtg gccttccgga ggctccagcg cggtggcgag cgcggcatgg gcggcgtacg
     7621 aggtgccgca ggcgacgacg cgcccgtcgc tccacggacg gctgcgcagc cagcgcaaca
     7681 cgacggcgcc gtcggcggct tcgtgcaggt acggccgcca ggtgccggtg gacccgtgcc
     7741 ggccgcgtac gtcctgggcg acggcggcga atccgtgccg ggcccaggcc cgcagttctg
     7801 catggtgcgc gacacggccg tacggagtgc gcaccagcac ggcggggaag ggccccgcgc
     7861 ccgcgggcag gcagtagtcg gtcgccagca ccgtgccgtc cgggacgggc acgtcggcat
     7921 ggcacagcgc gggcccggag gcggtggtgc tcatgcgatc cgggcagggc cggcgggccg
     7981 ggccggggca ggcaccgcgc ccggcgcgcc ttccggtgcg gtcggcagcg gcgccacggc
     8041 gggcacgggc aggacggggt gttcggagac cgacaggtcg cgcaggtcga gccggcgcag
     8101 ccggcgggag gcgggcaggc cggcgccgcc cggagaccgc ccggtgcgta cgcccgcggt
     8161 cgcccatgcc gtcaagtcgg tggcgagcag agcggcgacg aacgcggcac cggccgccgt
     8221 gccgcccggg cacggaccgg tggcggaggc ggcgccccag tacgcggcca gctcccggtg
     8281 cgcgggggtg gcggcgagcc tgcgggcgcg gacatggcgg gcgagaacgt cccccgcccc
     8341 cgcggcgagc ggctcgaccc acgcctgcag gccctcccgg tgagagcggg cccaggcgat
     8401 gccgcgcgcg ggcaaccggt cggcggcgtc ccagaggccg gccggcaccg gccggtcgag
     8461 gcaccacacg acagccgcga cgggggccgc ggtgggcgcc gtcaccgata cgcctccggt
     8521 cgccgggccg ccccggagcc gtccggcggc gagcgcggcg acctcctccg gcgtaccggc
     8581 gcggggccgg gcgcccgcgg ccgagaggag gccggccagc ggcccggtca actccgcgtc
     8641 gccgagcagc aggacgcccg cgcgttcggc cggccagacg gccggcgggt ccaggtagcc
     8701 ggcgtcggcg aaggcggtga gcagccgccg ggcctcctcg tccgccgccg ccgggccgcc
     8761 cggccgtgca ccggcggtgc cgtccagctc ggccagcagc cgggcaacgg cgccgggttc
     8821 ggcgtcgacg tgcaggaact cgccgtcggg tgtgcggacc gcggtgggcc gcccggggac
     8881 gtcgaagacg tccacgccgg gggcgagtcg ggggcggggc aacattcctc ctggccggtg
     8941 ggtggggagc acggtgcggg cggcccgacg ggccgcgtac ggaacgggac gggcccgccc
     9001 gggcgctgct ccgggcgggc ccgcgtctgc cggttactcc tgctcgtcgt cgaaggggtt
     9061 ctcgacgagg gcgttggagt gggtggcgga caggtgggcg agctggcccg gctcctccac
     9121 cggcttgaag accggctgct cctgctccat ggggttcctc ccaacgtggt gacggtcagc
     9181 gccctgttga gcgctgcgct cacgttaatg aatatgattt tcatacgcaa gaggggtggg
     9241 tgtgtcggga tagcacaccg gccatccgtg caccgggtcc cgccccacgc ggccctcgac
     9301 gccgaagacc tcccgcagca gctccggcgt gaccacgtcc tgcggccggc cgtccgcggc
     9361 cacgcgcccg tcccgcagcg ccaccagccg ctcgctgaac cgggccgcga gaccgaggtc
     9421 gtgcaggacc atgagcaccg tcatccggcg ctccgagcgc agccgcgtca ccgactgcag
     9481 cacctccagt tggtgccgca ggtccaggta cgtcgtcggc tcgtccagga gcagcagcgg
     9541 ggcgtcctgc gccagcgcga gcgctagccg tacgcgctga cgctcgccgc cggagagcgc
     9601 gtcgaccggc cggtcggccc agccgtcgac gccgacgtcc gccatcgcgc gcaggctcac
     9661 cgcgtcgtcg ccgtcccgca gcatcccgag ggggccccgg gccgcgtacc ggccctgccg
     9721 tacgagctga cgcaccgtca tccccggtac ggcgggcgcc gactggtgca gcagcgcgac
     9781 ccgccgcgcc gccgcccggc gtggcagccg ggagacgtcc gcgcccgcca cccggatccg
     9841 cccggcatcg ggccgcagca tgcccgcggc gaggcgcagc agcgtgctct tgccgcagcc
     9901 gttgaggccg acgagcgcga cgagttcgcc ggggcgcacg gtgaggctca ccccgtcgag
     9961 tacccgccgc cccgggtagc cgaagccgag ccggtccgcc tccagggccg gcgggtcgcc
    10021 ctcgccggga cccggagccg gtggtgcgga tgcggcggtc gcgggctcgg tcacgtcgtg
    10081 ctcctcacgg atacgcgggc gggctctcgc gacggcgcgg gcccccgccc gtacggggtc
    10141 atagttcggt cgtgtggcgg cgcgcgacga ccagcaggac ggccgcgccg accgccgtcg
    10201 tcaccgcgcc cacgggaatg ctcagacgct cggcgcccca cgacaccgcg gcacgggagg
    10261 cgagttgggc ggcggcgtcc gcgccgcaca cggcgaccgc cccggccagc gcggccccgg
    10321 gcagggcgag gcgcagatcc gcgccgagca gcgcgagcgc cacgtgcggc accagcagcc
    10381 ccacgaaccc gagtgcgccg acggccgcga cggcacccgc ggtcagcccc accgcgcaga
    10441 ccagggcgag cacccgggcc cgggacgagg cgagtcccgc ggcccgcgcc acgtcctcgc
    10501 cgcagcgcag cagcatcagc ggccccgccg tcagccaggc cgccgcgccc cacgcgagcg
    10561 cccacggcca cagcagcgcc cagtgctccc acgtacgggc ctccgtggtg ccgaccagcc
    10621 actgcacgac gctgcccagt tcacccggcg cgacgagcag caccatcgcg gtcaggccgc
    10681 cgagcacggc ggagaccagc acaccgtgca ccgccacggc cgccgggtcg gcgcggtccc
    10741 ggccggccag cagccacagc agacccgccc cggcgcagcc gccggcgacg gccgcgacca
    10801 cgacggcggt gggcgagtcc cacccggcaa gacccgcccc ggacgccgcg acggcgccga
    10861 gcacggcgcc cggggtgacg ccggtgacct cggggccggc cagcgggttg cgcagcgcgg
    10921 cctggagcac cagccccgcg agtcccaggc aggcgcccgc gaccagggcg accaggacgc
    10981 gcggcacccg cagtcgccac acgacgtggc gcgtcgtcgg gtccacgtcg ccgccggtga
    11041 gcgcgggcca cacctcgccc ggtgcgacgg cgcccccggc gaggaggccg gccacggcgg
    11101 cgaccaggac ggcggccgtg aggccgccca ggaccagccg gggaccgtac gccgtacggg
    11161 ccttcatccc gcacccccgt cggccgggcc acgatcgccc gcgtcagcgg cggtgccgct
    11221 gccggcgggc agggaccgta cgggcgcccg cacgcgtgcg cccgcggcgc cggtcgccgc
    11281 cgcgtccgta cccgacgccg gggaggcttc ggaagcggcc gccccgcgac ccgctcgctc
    11341 cgagccgtac cgcaaccgcc gcggcccgtc ccgccggtca
//
