LOCUS       NZ_CP029618            21215 bp    DNA     linear   CON 19-MAY-2024
DEFINITION  Streptomyces sp. WAC 06738 chromosome, complete genome.
ACCESSION   NZ_CP029618
VERSION     NZ_CP029618.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces sp. WAC 06738
  ORGANISM  Streptomyces sp. WAC 06738
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8324535)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Evolution of GPA BGCs
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8324535)
  AUTHORS   Waglechner,N. and Wright,G.D.
  TITLE     Direct Submission
  JOURNAL   Submitted (25-MAY-2018) Michael G DeGroote Institute for Infectious
            Disease Research, McMaster University, 1280 Main St West, Hamilton,
            Ontario L8S 4L8, Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: HGAP v. Jun-2017
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 148.0x
            Sequencing Technology             :: PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003945505.1-RS_2024_05_19
            Annotation Date                   :: 05/19/2024 05:01:44
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,191
            CDSs (total)                      :: 7,115
            Genes (coding)                    :: 6,917
            CDSs (with protein)               :: 6,917
            Genes (RNA)                       :: 76
            rRNAs                             :: 5, 5, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 5, 5, 5 (5S, 16S, 23S)
            tRNAs                             :: 58
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 198
            CDSs (without protein)            :: 198
            Pseudo Genes (ambiguous residues) :: 0 of 198
            Pseudo Genes (frameshifted)       :: 107 of 198
            Pseudo Genes (incomplete)         :: 115 of 198
            Pseudo Genes (internal stop)      :: 5 of 198
            Pseudo Genes (multiple problems)  :: 27 of 198
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:28:43
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3583486
            Orig. end                         :: 3604701
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP029618.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Gerard D Wright, McMaster
            University, 1280 Main St West, Hamilton ON, Canada.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21215
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="8"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21215
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21215
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11215](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11215
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            355..1281
                     /locus_tag="DMB38_RS15350"
                     /old_locus_tag="DMB38_15355"
     CDS             355..1281
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (37-290). E-value: 2e-26.
                     Score: 85.0. Matches aSDomain:
                     nrpspksdomains_DMB38_RS15350_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835856.1"
                     /locus_tag="DMB38_RS15350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15355"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_125935670.1"
                     /sec_met_domain="PF00561 (E-value: 3.5e-18, bitscore: 64.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.6e-21, bitscore:
                     74.6, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPSPVDPAVHLEGPWTHRDVAANGARFHIVEMGEGPLVLLLHG
                     FPQFWWTWRHQLPALAEAGYRAVAMDLRGVGGSDRTPRGYDPANLALDVTGVIRSLGEP
                     DAALVGHDLGGYLAWTAAVMRPKLIRRLTVASMPHPRRWRSAMLTDPRQSAAGSFVWSA
                     QRPWLPERQLVADDAALVGRLIRGWSGPRQPDDKALEVYRRAMTVPSTAHCSVEPYRWL
                     VRSLGRPDGIQFYRRMKLPVRVPVLHLHGSLDPVMRTRSAAGSVAYVEAPYRWRLFDGL
                     GHFPHEEDPVAFTTELVNWLRDSEPDR"
     aSDomain        466..1224
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMB38_RS15350_Abhydrolase_1.1"
                     /evalue="2.00E-26"
                     /label="DMB38_RS15350_Abhydrolase_1.1"
                     /locus_tag="DMB38_RS15350"
                     /protein_end="290"
                     /protein_start="37"
                     /score="85.0"
                     /tool="antismash"
                     /translation="PLVLLLHGFPQFWWTWRHQLPALAEAGYRAVAMDLRGVGGSDRTP
                     RGYDPANLALDVTGVIRSLGEPDAALVGHDLGGYLAWTAAVMRPKLIRRLTVASMPHPR
                     RWRSAMLTDPRQSAAGSFVWSAQRPWLPERQLVADDAALVGRLIRGWSGPRQPDDKALE
                     VYRRAMTVPSTAHCSVEPYRWLVRSLGRPDGIQFYRRMKLPVRVPVLHLHGSLDPVMRT
                     RSAAGSVAYVEAPYRWRLFDGLGHFPHEEDP"
     gene            complement(1695..2894)
                     /locus_tag="DMB38_RS15355"
                     /old_locus_tag="DMB38_15360"
     CDS             complement(1695..2894)
                     /EC_number="3.4.21.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018102139.1"
                     /locus_tag="DMB38_RS15355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15360"
                     /product="MarP family serine protease"
                     /protein_id="WP_125935671.1"
                     /transl_table=11
                     /translation="MNVLDILLVAAAVWFAVVGYRQGFVVGVLSVCGFVGGGLLAIYLL
                     PVIWDLVTDGAALGPTAAFGAIVLVLIAASVGQGLTTHLGNQLRQYITWSPARSLDATG
                     GALVNVVALLLVAWLLGTALASTTLPTVAREVRASKVLNGVAEVMPKSADTWFGEFSSV
                     LSENRFPQVFAPFQSEQITNVPAPDPALVGSPVVEQARKSIVKVVGTAQSCGKVLEGTG
                     FVFAPQRVMTNAHVVGGVDEPTVQIGGEGRLYDGEVVLYDWERDIAVLEVPGLDAPALP
                     FDQNDASRGDDAIVAGFPENGGFDVRAARVRDRITANGPDIYRRGTVNRDVLSLFTLVR
                     QGNSGGPLLTPEGAVVGVIFARSMDDKDTGYALTVDEVRDDIERGRTASQPVDSDSCAM
                     "
     gene            complement(2907..3569)
                     /locus_tag="DMB38_RS15360"
                     /old_locus_tag="DMB38_15365"
     CDS             complement(2907..3569)
                     /EC_number="3.6.1.55"
                     /GO_component="GO:0005777 - peroxisome [Evidence IEA]"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0003986 - acetyl-CoA hydrolase activity
                     [Evidence IEA]"
                     /GO_function="GO:0008413 - 8-oxo-7,8-dihydroguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_function="GO:0010945 - coenzyme A diphosphatase
                     activity [Evidence IEA]"
                     /GO_function="GO:0030145 - manganese ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0035539 - 8-oxo-7,8-dihydrodeoxyguanosine
                     triphosphate pyrophosphatase activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0009132 - nucleoside diphosphate metabolic
                     process [Evidence IEA]"
                     /GO_process="GO:0015938 - coenzyme A catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129288.1"
                     /locus_tag="DMB38_RS15360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15365"
                     /product="CoA pyrophosphatase"
                     /protein_id="WP_125935672.1"
                     /transl_table=11
                     /translation="MAVSDAGLPGWLAPVAEAARTVRPEELSRFLPPDGDGGRPAAVLV
                     LFGDGDDGPELLLTERASSLRSHAGQPSFPGGSLDPEDGDPEGEGPLRAALREAQEETG
                     LDPAGVQVFSVLPRLYIPVSGFVVSPVLGWWRERSPVGVVDPAETARVFSVPVADLTDP
                     ANRAMAVHPRGHLGPAFLVCSALVWGFTAGVIDRILHLAGWERPWDRDRRVPLDWHA"
     gene            complement(3917..4747)
                     /gene="nth"
                     /locus_tag="DMB38_RS15365"
                     /old_locus_tag="DMB38_15370"
     CDS             complement(3917..4747)
                     /EC_number="4.2.99.18"
                     /GO_function="GO:0140078 - class I DNA-(apurinic or
                     apyrimidinic site) endonuclease activity [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="nth"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841330.1"
                     /locus_tag="DMB38_RS15365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15370"
                     /product="endonuclease III"
                     /protein_id="WP_125935673.1"
                     /transl_table=11
                     /translation="MAKSGKAASAAGGRAVVRKAKPAPTRTGLVRQARRIYRELAEVYP
                     YAHPELDFENPYQLLIATVLSAQTTDLRVNQTTPALFAKYPTPEDLAAANPEEVEELIR
                     PTGFFRAKTKSIMGLSQALRDDFGGEVPGNLKDLVKLPGVGRKTAFVVLGNAFGVPGIT
                     VDTHFARLVRRWKWTEQTDPEKIEQEVGSLFPKKDWTMLSHYVIFHGRRICHARKPACG
                     ACPIAPLCPAYGEGETDPEKAQKLLKYEKGGMPGQRLKPPPDYPGKPAPPLGAA"
     gene            4894..5145
                     /locus_tag="DMB38_RS15370"
                     /old_locus_tag="DMB38_15375"
     CDS             4894..5145
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835851.1"
                     /locus_tag="DMB38_RS15370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15375"
                     /product="hypothetical protein"
                     /protein_id="WP_018835851.1"
                     /transl_table=11
                     /translation="MVPDDAVIGCLGVLVIPTRGSAGPGEVLVRVRGGTETFLAWSAEP
                     LPQGAEVLVTEYCGGRQVTVIAWADPLDELTGGIGPVE"
     gene            5156..6268
                     /locus_tag="DMB38_RS15375"
                     /old_locus_tag="DMB38_15380"
     CDS             5156..6268
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841329.1"
                     /locus_tag="DMB38_RS15375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15380"
                     /product="flotillin family protein"
                     /protein_id="WP_125935674.1"
                     /transl_table=11
                     /translation="MFGYRVPAPDQAMLVSGGRRRRDGAPFRVVVGHGGFVLPIFRKTR
                     FLSLAMHESEVAEYCVTRQGIPLTVRSVIAFKVGNDIESIVNAGQRFLSEQKEMSVLTG
                     RIFAGHLRAIIGSMTVEEIVTERQKLASEVVETSKSEMGRIGLIVDSFQIQSIDDGDTG
                     YIKAMSAPHQAAIQREAKIAEAQAAQKASEAEQESARKQAEYARETAMVRAQYKAEVSR
                     VEAEAAQAGPLAQAHAQQDVLAAQTELAERAARLRQQELQAEVVKPAEAEAERVRVLAL
                     AEAERMKIQAEAASSYDRVALDQQLIDQLPKIVERAAAGLQGANINVLNGADGLGELTA
                     GLVGQGLAILDSVRTTMPQPRSPESERLND"
     misc_feature    5267..5269
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6446..7423
                     /locus_tag="DMB38_RS15380"
                     /old_locus_tag="DMB38_15385"
     CDS             6446..7423
                     /NRPS_PKS="Domain: PKS_ER (33-322). E-value: 1.6e-35.
                     Score: 114.6. Matches aSDomain:
                     nrpspksdomains_DMB38_RS15380_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850888.1"
                     /locus_tag="DMB38_RS15380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15385"
                     /product="zinc-binding dehydrogenase"
                     /protein_id="WP_125935675.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.1e-25, bitscore:
                     87.9, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVAVRAIEVREFGGPEVLVPAEVPEPVAGAGQVVVGLEVADVIYL
                     DTLLRAGWGGDIFPVRPPYVPGQGGAGTVLAVGEGVDAAWAGRRVAAPASAGYAEQVVA
                     EVAEIAPVPDGLGLAEAGALLHDGTTAVLLARAGKVREGETVLVAAAAGGAGSLVLQLA
                     RDAGARVIAAARGERKLALARELGAEHTVDYSEDGWQDRVRDAAGGDGVDLAFDGAGGE
                     LGRAAFRAVARGGRFVTYGTSGGTFAEIDPRTAAERDVRVTNLLEGGPPPAAVSQAALV
                     EALDLAAAGRIRPVIGATYPLARARDAHDSLARRATVGKSLLVV"
     aSDomain        6545..7411
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMB38_RS15380_PKS_ER.1"
                     /evalue="1.60E-35"
                     /label="DMB38_RS15380_PKS_ER.1"
                     /locus_tag="DMB38_RS15380"
                     /protein_end="322"
                     /protein_start="33"
                     /score="114.6"
                     /tool="antismash"
                     /translation="VVGLEVADVIYLDTLLRAGWGGDIFPVRPPYVPGQGGAGTVLAVG
                     EGVDAAWAGRRVAAPASAGYAEQVVAEVAEIAPVPDGLGLAEAGALLHDGTTAVLLARA
                     GKVREGETVLVAAAAGGAGSLVLQLARDAGARVIAAARGERKLALARELGAEHTVDYSE
                     DGWQDRVRDAAGGDGVDLAFDGAGGELGRAAFRAVARGGRFVTYGTSGGTFAEIDPRTA
                     AERDVRVTNLLEGGPPPAAVSQAALVEALDLAAAGRIRPVIGATYPLARARDAHDSLAR
                     RATVGKSL"
     gene            complement(7440..8969)
                     /locus_tag="DMB38_RS15385"
                     /old_locus_tag="DMB38_15390"
     CDS             complement(7440..8969)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841327.1"
                     /locus_tag="DMB38_RS15385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15390"
                     /product="MFS transporter"
                     /protein_id="WP_125935676.1"
                     /transl_table=11
                     /translation="MSPTDAVAGSGPAGETGPPAVAVMPQDDRAHRHRWLILGVLGLAQ
                     LMVVLDVTIVNIALPSAQSDLGFTNGDRQWVVTAYSLAFGSLLLLGGRIADLVGRKVTF
                     LVGLVGFAAASAVAGAAVSFDMLILARAFQGASGALLAPSALSLLTTTFTDPGERAKAF
                     SVYGAVSGAGGAIGLLLGGVLTEYLDWRWTLYVNVALAVVAFGFASALLTRTARDRSVT
                     LDVPGTALVTAGLFCVVYGFSNAEHQDWGAPATWGLLIAGGVLLTAFAWWSTRSQHPLL
                     PTRIVTDRNRGASYLGMLISAGGMFGVFLFLTYFLQTGLDYTPIDSGVAFLPMVGGLVI
                     AATLATNVLVPRIGPRLVVPSGMAIAAAGLVWMTSLDLNSSYAADILPMTVIVGFGLGL
                     IVATAMSLGTLGVSVHDAGVASATVNAMQQVGGSIGIALLNTVSASAATNYLSGRDPRD
                     PAVKAQAALESYHTAFWWSAGFFAAGALVTLFLYRRGAPKELKGGAPTIHM"
     misc_feature    complement(8963..8973)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     misc_feature    complement(9027..9043)
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.26"
                     /tool="antismash"
     misc_feature    complement(9028..9043)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.53"
                     /tool="antismash"
     gene            complement(9154..9777)
                     /locus_tag="DMB38_RS15390"
                     /old_locus_tag="DMB38_15395"
     CDS             complement(9154..9777)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1224: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835846.1"
                     /locus_tag="DMB38_RS15390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15395"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_125935677.1"
                     /transl_table=11
                     /translation="MPGRPVGQLHGQAPDARIRRPRMTPERERELLEAVLGVLRESGYE
                     ALSMDLVATRARCSKATLYRQWHSKAEMVVAAMIANRPVDPGAVDTGSLRGDLISLVEE
                     LSTTAEKDTALIAAIHHAALTDGDLAATLHASLADYELTHLSGLLDRAVARGELPGQPG
                     AAEFLPQLLFGAVVIRPLIDGAFADSAYLARFVDLVVLPALRHS"
     gene            10001..11215
                     /locus_tag="DMB38_RS15395"
                     /old_locus_tag="DMB38_15400"
     CDS             10001..11215
                     /GO_component="GO:0140737 - encapsulin nanocompartment
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835845.1"
                     /locus_tag="DMB38_RS15395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15400"
                     /product="family 2 encapsulin nanocompartment cargo protein
                     terpene cyclase"
                     /protein_id="WP_125935678.1"
                     /sec_met_domain="T1TS (E-value: 4.1e-53, bitscore: 180.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGAPAEALRALLPLGPTGLGTAAAHPLAGYVPEAVPKPEAEPPA
                     RTKPRPEPASGAGPGTDSDPGSASAAGPEAGTAPPPDGSGERGGLRIPPLYCPDALRND
                     PALGDEVNERLVAWAEEIGIFTGRIERLRSHQFGRLFMLAHPDCDDPDRLLAAAKCGLS
                     EWSVDDHWVDEGEDPDPALLGERMALAHAVIDPVRLPARYMPQFEETVQREPVLRAFRS
                     ALAHLSRYASPTQVARLRHELAVMFVGYGQEAEWRSSARTPAVWEYLLHRYENAFFPCM
                     VLVDPVSGYELPPDEFADARVRRTYLYAGTASVLLNDLYSMGKEDPTDTNLPNLIAAEE
                     GCTLQEAVDRTALIHDELMHTYEMEAAALTAAGSPQLGRFLAGVWAWMGGCKEWHATSA
                     RYQTA"
     misc_feature    complement(11388..11402)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 16.24"
                     /tool="antismash"
     gene            11408..12262
                     /locus_tag="DMB38_RS15400"
                     /old_locus_tag="DMB38_15405"
     CDS             11408..12262
                     /EC_number="2.1.1.255"
                     /GO_function="GO:0008757 - S-adenosylmethionine-dependent
                     methyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0042214 - terpene metabolic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (89-190). E-value: 6e-10. Score:
                     29.6. Matches aSDomain: nrpspksdomains_DMB38_RS15400_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018841325.1"
                     /locus_tag="DMB38_RS15400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15405"
                     /product="geranyl diphosphate 2-C-methyltransferase"
                     /protein_id="WP_125935679.1"
                     /transl_table=11
                     /translation="MAAAADTNVLTSPYQHSIADYWNREKDPVNLKLGDVSGTYHHHYG
                     IGEVDQSVLAGPEETREERIIAEMHRLETAQATLLLDHLGEPDRGARLLDAGSGRGGTS
                     FMAHERFGCRVDGISISQSQVSFANDQVQRRGLGSAVRFHLKNMLDTGFETGAFRGIWN
                     NESTMYVELAQLFKEHARLLARGGRYVTITGCYNDAYGLPSRAVSQINAHYICNVHPRS
                     TYFKELVANRLVPAEVIDLTEATIPYWELRAKSSVATGIEEVFLTAYRSGSFQYLLIAA
                     DRV"
     aSDomain        11675..11977
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_DMB38_RS15400_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="6.00E-10"
                     /label="DMB38_RS15400_oMT.1"
                     /locus_tag="DMB38_RS15400"
                     /protein_end="190"
                     /protein_start="89"
                     /score="29.6"
                     /tool="antismash"
                     /translation="GARLLDAGSGRGGTSFMAHERFGCRVDGISISQSQVSFANDQVQR
                     RGLGSAVRFHLKNMLDTGFETGAFRGIWNNESTMYVELAQLFKEHARLLARGGRYV"
     gene            12425..15829
                     /locus_tag="DMB38_RS15405"
                     /old_locus_tag="DMB38_15410"
     CDS             12425..15829
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850890.1"
                     /locus_tag="DMB38_RS15405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15410"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_125935680.1"
                     /transl_table=11
                     /translation="MRERLAYVRIGVLGPLEVAVGGVPVEIAGGRLRALLVRLALDPGR
                     YVGTTLLADGLWGDDAPADPGNALQSLVSRLRRALGRSDVLAYGPAGYRLALPPEAVDA
                     VRFERQAHAGREALAAGDAPAARRLLEEALTLWRGPALADVADAPFAAAPAHRLEELRL
                     EATEDRIEAGLAEGGPGGARPGAAVPELEALTVAHPLRERPRALLMRALYATGRQPEAL
                     GAYEEYRTLLAEELGADPSEALRELHVAVLRGGTPGRGGASGPYSTRPGATGDPYRTKP
                     GTGPGAPDDPPPPVRTNLRAALTSFVGRDGELRRVRALLGGSRLVTLTGPGGAGKTRLA
                     TTAAEALLDDSPGGVWLVELAPVTGGDDVPFAVLGALGQRETAVLDNRHLPPRDVLTRL
                     TDTLAAAPTTLVLDNCEHVVSAAAHLADHLLRRCPELRVLATSREPLGIDGEALCPVPP
                     LSLPPRDAEDGRDARDGQGEHATGAAVRLFADRARAARPDFAVGPANAAAVAEICRRLD
                     GLPLAIELAAARLRSLPVEQVAARLDNRFRLLTTGSRTALPRHRTLQAVVAWSWELLGD
                     EERRLAEWLSVFPGGATPESVAGVCGMDVVTALDLLAALADKSLLQIAEAPQGAHAEPS
                     AGPRYRMLETIREFGRDRLAEAGDLDRVRAAHAAHFLRLAETADPHVRGHEQLGWIALL
                     DAEHDNLLAALRHAIDAGDAVTAVRLVAALGIYWMILGHHSEAADWLRLALAVPGDPPL
                     EPHAVALGFSLINSATSGGIEPDPAALEELTALAARVDPMGGHPMLAVLEPGIAVFTDD
                     DARGLAAIDERLGHPDPWTRALLRMIRAAFRENRGYAPGLEEDLEAAAAEFREVGDRWG
                     LAMALHQLGEYRALLGDAERARAGFEEALRLMGEVHAEDDVGQLRTRLAQLEAAQGRTE
                     EARAELHRVLGAAVREGRSHVAALCRDVLGDLARRAGEADEAARWYGEALATLRRGGVA
                     VPQIEAIVRTGRALLACVRGDPAGARTELATALGVAVGVKDMPVVAMVGVGVATLAAEY
                     GETATGLTEEEHTGAEFARAAELLGAADSVRGVGDVALPDAADLAARLRRALGAEFEPA
                     RARGAALKQGDAIELLRAYLADTPGCP"
     gene            complement(15826..16647)
                     /locus_tag="DMB38_RS15410"
                     /old_locus_tag="DMB38_15415"
     CDS             complement(15826..16647)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1065: ABC-2 type
                     transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835842.1"
                     /locus_tag="DMB38_RS15410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15415"
                     /product="ABC transporter permease"
                     /protein_id="WP_125935681.1"
                     /transl_table=11
                     /translation="MTTLTAPERTAVPSRREGAARPFALVRHSVALAGRSLVKTRRTPE
                     QLIDVTLQPILFLVMFLYLLGGAVAGSTHAYLQTLLPALMVMNTAFASVQTGINLNDDI
                     KKGVFDRFRSMPIARSAPLIGSVLGDLIRFVVLIVVQLGFGYAVGFRVGTGLLPALAAC
                     LLVMLFVFCLSWVFVLIGMLVREPGAVQGVGFMAMFPLTFGTNVLVPTDTLPGWLETWV
                     DVNPVTGVMEAARGLMVEGPVAGPVLESVLWSAGVLAVFFPLAVRAYLRRT"
     gene            complement(16644..17648)
                     /locus_tag="DMB38_RS15415"
                     /old_locus_tag="DMB38_15420"
     CDS             complement(16644..17648)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835841.1"
                     /locus_tag="DMB38_RS15415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15420"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_125935682.1"
                     /transl_table=11
                     /translation="MTYAFRAEGLVKRFGATTALAGIDLAARQGTVLGVLGPNGAGKTT
                     AVRILATLLRPDEGTAAVGGLDVVRDAGEVRRLIGLTGQYASVDEDLTGTENLVLIGRL
                     LDMRTGAARARARELLAHFELAGAAGRPVRTYSGGMRRRLDLAASLVGRPDVIYLDEPT
                     TGLDPVRREDVWGIVRSLVGDGVTVLLTTQYLEEADALADEISVIDHGRVIAHGTPAEL
                     KRRVGGRHLDLRPLDPARLLDAAGILAAVAGTQPESPTRGTLTVPVADDGMLTAAVRRL
                     DEAGIAVAELSLRLPDLDDVFFTLTGHGTAAPAGSVTGTAGAARTPKTEEAVR"
     misc_feature    17711..17723
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.11"
                     /tool="antismash"
     misc_feature    complement(17742..17759)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 19.59"
                     /tool="antismash"
     misc_feature    complement(17912..17928)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 21.67"
                     /tool="antismash"
     misc_feature    complement(17954..17967)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.54"
                     /tool="antismash"
     misc_feature    complement(17989..18007)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 21.26"
                     /tool="antismash"
     gene            18078..18752
                     /locus_tag="DMB38_RS15420"
                     /old_locus_tag="DMB38_15425"
     CDS             18078..18752
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0030552 - cAMP binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1133:
                     Transcription regulator, crp"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003975365.1"
                     /locus_tag="DMB38_RS15420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15425"
                     /product="Crp/Fnr family transcriptional regulator"
                     /protein_id="WP_018835840.1"
                     /transl_table=11
                     /translation="MDDVLRRAPLFAALDDEQAAELRASMTEATLSRGDALFHEGEPGD
                     RLYVVTEGKVKLHRTSPDGRENMLAVLGPGELIGELSLFDPGPRTATASALTEVKLLGL
                     GHGDLQPWLNARPEVASALLRAVARRLRRTNDQMSDLVFSDVPGRVARALLDLSRRFGV
                     PGDEGIHVVHDLTQEELAQLVGASRETVNKALADFASRGWLRLEARAVILLDVERLAKR
                     SR"
     gene            complement(18774..19607)
                     /locus_tag="DMB38_RS15425"
                     /old_locus_tag="DMB38_15430"
     CDS             complement(18774..19607)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018850893.1"
                     /locus_tag="DMB38_RS15425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15430"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_125935683.1"
                     /transl_table=11
                     /translation="MTDAAALPGQPRGGALSGPATARATCVLAPNASPMTLDGTNTWIV
                     AEPDSARAVVIDPGPLDEGHLAAVMDTADRAGLRVALTLLTHGHADHAEGAARFAELTG
                     TKVRALDPALRLGDEGLAAGDVISVAGLELRVVPTPGHTADSLCFHLPADDAVLTGDTI
                     LGRGTTMVAHPDGRLGDYLDSLRRLRSLTVDDGVSTVLPGHGPVLEDAQGAVEFYLAHR
                     ATRLAQVETAVENGHRTAAEVVAHVYADVDRTLWPAAELSVRAQLEYLKEHGLIT"
     gene            complement(19642..20523)
                     /locus_tag="DMB38_RS15430"
                     /old_locus_tag="DMB38_15435"
     CDS             complement(19642..20523)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835838.1"
                     /locus_tag="DMB38_RS15430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15435"
                     /product="NUDIX hydrolase"
                     /protein_id="WP_125939055.1"
                     /transl_table=11
                     /translation="MNAANAAAGAQPRWIPPAERIRALARGELTPVTPRRAATVLLLRG
                     MAPDGPWVYMLRRKTSMPFAAGAYAYPGGGVDPRDERPLPAAAWAGPAPARWAARLGVA
                     EPEAQAVVCAAVRETFEEAGVLLAGASAAEVVADTTGADWEADRAALVARELGFADFLA
                     RRGLVVRTDLLGAWARWITPEFETRRYDTWFFVAALPEGQRTRNASTEADRAEWVRPAE
                     AAEGYERGELVMLPPTISMLRGLREYGSAAEALAAAGERDLSAVLVKARMEGDDVVLSA
                     PGHEEFTRRLPS"
     misc_feature    complement(20516..20527)
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(20694..21161)
                     /locus_tag="DMB38_RS15435"
                     /old_locus_tag="DMB38_15440"
     CDS             complement(20694..21161)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018835837.1"
                     /locus_tag="DMB38_RS15435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="DMB38_15440"
                     /product="RidA family protein"
                     /protein_id="WP_125935684.1"
                     /transl_table=11
                     /translation="MAGRVEEKLAELGLSLPEVVPPLASYVPAVRSGPYVFTAGQLPMV
                     DGTLPLTGKVGAEVTPEEARELAARCALNGLAAIKSVAGDLDRVVRVVKVVGFVASAPD
                     FTAQPGVVNGASELLGQVLGEAGVHARSAVGVAVLPLDAPVEIEFQAELAG"
ORIGIN
        1 caaggccgag acccgggagg acatcaagcg cgcgggcgcg ggcggcgccg ccctcggcgt
       61 cgccgcggtc ctcgtcctct tcggcatccc ggtgctcagc ttcgccgccg cgtacgggct
      121 ccacgccctg ggtctccacc tcgcctggtc gttcctcatc gtcttcggcg tccacctggt
      181 cctcggcgcg ctcgccgccc tctggggcat cgccaagatg cgccagatgc gcaagcccga
      241 gcgcgcgatg aactccacca aggagaccgc caccgtcatc tccgactccc tgcgcggccg
      301 aggtcatccg gcggaccgac gcaagccggc cgcgggcgtg gcacgctcgg agtcatgacg
      361 gcaccgtcgc cagtcgaccc ggcagtccac ctcgaggggc cctggaccca cagggacgtc
      421 gcggcgaacg gcgcccgctt ccacatcgtg gagatgggcg aagggccgct ggtgctgctg
      481 ctgcacggat ttccgcagtt ctggtggacc tggcggcacc aactgcccgc gctcgccgag
      541 gccggctacc gcgcggtggc gatggacctg cgcggcgtcg gcggcagcga ccgtacgccc
      601 cgcggctacg acccggcgaa cctcgccctc gacgtcaccg gcgtgatccg ctcgctcggc
      661 gagcccgacg ccgcgctcgt cggccacgac ctcggcggct atctcgcctg gaccgcggcg
      721 gtgatgcggc ccaagctgat ccgccggctg accgtcgcct cgatgccgca cccgcgccgc
      781 tggcgctccg cgatgctcac cgacccgcgg cagagcgccg cgggctcctt cgtctggagc
      841 gcccagcgcc cctggctgcc cgagcggcaa ctcgtcgccg acgacgccgc gttggtcggc
      901 cggctgatcc gcggctggtc ggggccgcgg cagccggacg acaaggcgct ggaggtctac
      961 cggcgcgcca tgaccgtgcc ctcgacggcg cactgctcgg tggagccgta ccgctggctc
     1021 gtacggtcgc tggggcggcc cgacggcata cagttctacc gccgcatgaa gctgccggtg
     1081 cgggtgccgg tgctgcacct gcacggatcc ctcgatccgg tgatgcgcac gcgcagcgcg
     1141 gcgggatccg tcgcgtacgt ggaagcgccg taccggtggc gccttttcga cggtctcggg
     1201 cacttcccgc acgaggagga cccggtcgcg ttcacgaccg aactcgtcaa ctggctacgg
     1261 gattccgagc ccgaccgctg acgccgcgca gctcaccgtc cggtccacgg cccgtacggc
     1321 atcctccgcc accaccgcgg ccggtacccg gcgccgccgc cgctggaact ggacacgtca
     1381 attgcaccct gcataggccg atgggcccgg gaaagggcga ttaccggccg ccttgcgggg
     1441 ggaggatccg gggtatgggt tggacgcatg actacaacga cgtaggaacc caccgcgcca
     1501 ccaccccgga cgccagaccg ctccggggcg cctcggcgca tcgcgaagtg gacctccgtc
     1561 tggggatccc gcacattctc cgccgccggg cccgctggat gagcgcccgg ttgcggcgcg
     1621 tgcactgagc ggcccgcccg cgacccgtcc cgacgtggat tccgggggcc gtgccccccc
     1681 ggctcctccg cggctcacat ggcgcaactg tcgctgtcca cgggctgcga cgccgtgcgc
     1741 ccgcgctcga tgtcgtcgcg gacctcgtcg accgtcagcg cgtagccggt gtccttgtcg
     1801 tccatggacc tggcgaagat gacgccgacg acggcgcctt cgggagtgag cagcgggccg
     1861 cccgagttgc cctggcggac cagggtgaag agggagagca cgtcgcggtt gacggtgccg
     1921 cggcggtaga tgtccgggcc gttggccgtt atgcggtcgc gcacgcgcgc cgcccgtacg
     1981 tcgaagccgc cgttctccgg gaagccggcg acgatggcgt cgtcgccgcg gctcgcgtcg
     2041 ttctggtcga acggcagcgc gggggcgtcc agcccgggga cctccagcac ggcgatgtcc
     2101 cgctcccagt cgtagagcac gacctcgccg tcgtagagcc tgccctcgcc gccgatctgc
     2161 acggtgggct cgtcgacgcc gccgacgacg tgggcgttgg tcatcacgcg ctgcggcgcg
     2221 aagacgaacc cggtgccctc cagcaccttg ccgcacgact gcgccgtgcc gacgaccttg
     2281 acgatgctct tccgggcctg ctcgaccacc gggctgccga ccagcgcggg gtcgggcgcc
     2341 ggcacgttgg tgatctgctc gctctggaac ggcgcgaaga cctgcgggaa gcggttctcc
     2401 gacagcacgg aactgaactc gccgaaccag gtgtcggcgc tcttcggcat cacctcggcc
     2461 acgccgttga gcaccttcga cgcgcgcacc tcgcgggcga cggtcggcag cgtcgtcgac
     2521 gccagcgccg tgccgaggag ccacgcgacg agcagcagcg ccacgacgtt gaccagcgca
     2581 ccgccggtgg cgtccaggga gcgggcgggc gaccaggtga tgtactgccg cagttggttg
     2641 ccgaggtggg tggtgaggcc ctggcccacc gaggccgcta tgaggacgag gacgatggcg
     2701 ccgaacgcgg ccgtcgggcc gagggcggcg ccgtcggtca ccaagtccca gatgacgggc
     2761 agcagataga tggcgagcag cccgccgccc acgaagccgc acacggacag gacaccgacc
     2821 acgaagccct ggcggtagcc gaccacggcg aaccacacgg cggccgccac cagcaggatg
     2881 tccagcacgt tcacccggtc accgtctcat gcgtgccagt ccagcggcac ccggcggtcg
     2941 cgatcccacg ggcgctccca cccggccagg tgcaggatgc ggtcgatgac gcccgcggtg
     3001 aaaccccaga ccagcgcgga gcagacgagg aacgcgggcc cgaggtggcc gcgcggatgg
     3061 acggccatgg cgcggttcgc cgggtcggtg agatccgcca cggggacgct gaacacccgc
     3121 gcggtctcgg ccggatcgac gacgccgacg gggctgcgct cgcgccacca gccgagcacg
     3181 ggcgagacga cgaagccgct gacggggatg tagagccgcg gcagcacgga gaacacctgc
     3241 acgcccgcgg ggtcgagccc cgtctcctcc tgcgcctcgc gcagcgcggc gcgcagcggc
     3301 ccttcgccct cggggtcgcc gtcctccggg tcgagggagc cgccggggaa ggagggctgg
     3361 ccggcgtgcg agcggagaga gctggcgcgc tcggtgagca gcagctcggg gccgtcgtcg
     3421 ccgtcgccga agaggacgag cacggcggcg ggccggccgc cgtcgccgtc gggtgggagg
     3481 aagcggctca gctcttccgg ccgtacggta cgggccgctt cggcgaccgg cgccagccag
     3541 ccgggcagcc cggcgtcgct gacggccacg ggcggccggc ccgcgggcgc ggcagagccg
     3601 gacgcacgcg actggcgcgt cgctgacgca gaggatccgg gcgtacggga cgcgtgcgta
     3661 cgggctccgg gcgtacccga ccccggcgtg gcggacccgg gcgcctggga cacgggcgtt
     3721 cgacccacgg gcgtacgagc ggaatccgcg ccgtcggcgg gcccgtccgc ggcgctcgcg
     3781 gcgccgtgcg cgcccccgtc cgcttcaccg cgcgcctcac ccgccgccgc ccgcgccgaa
     3841 gcaccgggcg ccgcctcgtc cgccgtgccg cgcgccgcac cgccgcccgg cccgccgggc
     3901 gtcccgagag agggcgtcat gcggctccca gcgggggcgc gggcttcccg gggtagtccg
     3961 gcgggggctt gaggcgctgc ccgggcatgc cgcccttctc gtacttcagc agcttctgcg
     4021 ccttctccgg gtccgtctcc ccctcaccgt acgccgggca gagcggggcg atggggcagg
     4081 cgccgcaggc gggcttgcgg gcgtggcaga tgcgccggcc gtggaatatc acgtagtgcg
     4141 agagcatcgt ccagtccttc ttcggaaaga gggacccgac ctcctgctcg atcttctcgg
     4201 ggtcggtctg ctcggtccac ttccagcgcc gcacgagccg cgcgaagtgc gtgtcgaccg
     4261 tgatgccggg gaccccgaaa gcgttgccga gcacgacgaa cgccgtcttg cggcccacgc
     4321 cgggcagctt caccaggtcc ttcaggttcc ccgggacctc gccgccgaag tcgtcccgca
     4381 gggcctgcga cagccccatg atcgacttgg tcttggcgcg gaagaacccg gtgggccgga
     4441 tgagctcctc gacctcctcg gggttggccg cggccaagtc ctccggcgtc gggtacttcg
     4501 cgaagagcgc cggcgtcgtc tggttcaccc gcaggtcggt ggtctgcgcg gagagcaccg
     4561 tggcgatgag caactgatac gggttctcga agtccagctc cgggtgcgcg tacggataca
     4621 cctcggccag ctcgcggtag atccgccggg cctgccgcac cagccccgtc cgcgtcgggg
     4681 ccggtttcgc cttgcgcacc accgcgcggc cccccgccgc cgatgccgcc ttgccactct
     4741 tcgccatggg gccagcctac gggccccggc tgacaccgaa gcgtgaaacc gcgggggccc
     4801 ctcccgggga ggcgaaacca agattgagcg gccgtcgtcg tgagtagggt acgcatgaac
     4861 gtcgcgagca gggtgatgga ggggaatcca tcgatggtgc ctgacgacgc cgtgatcggc
     4921 tgtctgggcg ttctcgtcat ccccacccgc gggtccgcgg gccccggcga ggtgctggtg
     4981 cgggtgaggg gtggcaccga gacctttctc gcctggtccg ccgagccgtt gccgcaaggg
     5041 gcggaggtgc tcgtcaccga gtactgcggc ggtcgccagg tcaccgtgat cgcgtgggcc
     5101 gatccgctgg acgagctgac cggcggcatc gggcccgtgg agtgaggagg taagcatgtt
     5161 cggctatcgc gttccggccc ccgaccaggc catgctcgtg tcgggcggca ggcgccggcg
     5221 ggacggcgca ccgttccgcg tcgtcgtcgg gcacggcggg ttcgtgttac cgatcttccg
     5281 caagacccgc ttcctgtcgc tggcgatgca cgagtccgag gtcgccgagt actgcgtgac
     5341 caggcagggg atcccgctca ccgtacggtc cgtgatcgcc ttcaaggtcg gcaacgacat
     5401 cgagagcatc gtcaacgccg ggcagcgctt cctctccgag cagaaggaga tgtcggtgct
     5461 gaccggccgg atcttcgccg gccacctgcg cgccatcatc ggctcgatga cggtcgagga
     5521 gatcgtcacc gagcggcaga agctcgcctc ggaggtggtg gagacctcca agagcgagat
     5581 gggccggatc ggtctgatcg tcgactcgtt ccagatccag tcgatcgacg acggcgacac
     5641 cggctacatc aaggcgatgt cggcgcccca tcaggcggcc atccagcgcg aggcgaagat
     5701 cgccgaggcg caggcggcgc agaaggcgtc cgaggcggaa caggagtccg cccggaagca
     5761 ggccgagtac gccagggaga ccgccatggt gcgggcgcag tacaaggccg aggtcagccg
     5821 ggtcgaggcg gaggcggcgc aggccgggcc gctggcgcag gcgcacgcgc agcaggacgt
     5881 gctcgccgcc cagaccgagc tggccgagcg cgcggcccgg ctccgccagc aggagttgca
     5941 ggcggaggtg gtcaagccgg ccgaggcgga ggccgagcgg gtgcgggtgc tggccctcgc
     6001 cgaggcggag cggatgaaga tccaggccga ggcggcgtcc tcgtacgaca gggtggcgct
     6061 ggaccagcag ttgatcgacc agctcccgaa gatcgtcgaa cgggccgcgg ccggcctcca
     6121 gggcgcgaac atcaacgtgc tcaacggggc cgacgggctc ggcgaactca cggcggggct
     6181 ggtcggccag ggactggcca tcctggactc ggtcaggacc accatgcccc agccccggtc
     6241 ccccgagagc gaacggctga acgactagcg cacatcgatc cggccttccc ggccctctcc
     6301 cccgccggcg ggcatcccgt acggccggga gaggccggcc gccgcccgac agcggggtgt
     6361 gctggtcccc gcggcgggtg tcgcttgacc tgaaccatcg ttgaacttct acgtttggcc
     6421 ccgtcgagtc gatcaggacg ggagcgtggt cgcggtgcgt gcgatcgagg tgcgggagtt
     6481 cggcgggccc gaggtgctgg tgccggcgga ggtgcccgag ccggtggccg gggccgggca
     6541 ggtcgtcgtg gggctggagg tggccgacgt catctacctg gacaccctgc tgcgggccgg
     6601 ctggggcggc gacatcttcc cggtgcggcc gccgtacgtg ccgggccagg gcggcgcggg
     6661 gaccgtgctg gccgtcgggg aaggggtcga cgcggcgtgg gccgggcggc gcgtggccgc
     6721 cccggcgtcc gccgggtacg cggagcaggt cgtcgccgag gtggcggaga tcgctcccgt
     6781 ccccgacggg ctcggcctgg cagaagcggg ggccctgctg cacgacggca ccaccgcggt
     6841 gctcctcgcc cgcgcgggga aggtccgcga gggcgagacg gtgctcgtgg cggcggcggc
     6901 cggcggggcg ggatcgctgg tgctgcaact ggcgcgcgac gcgggggcgc gcgtcatcgc
     6961 ggcggcgcgc ggcgagcgca agctcgcgct cgcccgcgag ctgggcgcgg agcacaccgt
     7021 cgactactcc gaggacggct ggcaggaccg ggtccgcgac gccgccggcg gggacggcgt
     7081 cgacctggcc ttcgacggcg ccgggggcga gctgggccgg gcggcgttcc gtgcggtggc
     7141 gcggggcggc aggttcgtga cgtacgggac gtcgggcggg accttcgccg agatcgaccc
     7201 gcgcacggcc gcggagcggg acgtacgggt gaccaacctc ctggagggcg gcccgccgcc
     7261 cgccgccgtc tcgcaggccg ccctcgtcga ggccctggac ctcgccgccg cgggccgcat
     7321 caggccggtg atcggcgcga cctacccgct ggcgcgcgcc cgggacgcgc acgactcgct
     7381 cgcccggcgg gcgacggtgg gcaagtcgct gctcgtcgtg tgagggcgcg ggcggggctt
     7441 cacatgtgga tcgtgggtgc cccgcccttc agctccttcg gtgcgccccg ccggtacagg
     7501 aacagggtca ccagggcgcc ggcggcgaag aaacccgccg accaccagaa cgcggtgtgg
     7561 taactctcca gcgccgcctg cgccttcacg gccgggtccc tgggatcgcg ccccgagagg
     7621 tagttcgtgg cggcgctggc ggagacggtg ttgagcaggg cgatgccgat ggagccgccg
     7681 acctgctgca tggcgttgac cgtcgcggag gccacgcccg cgtcgtggac ggagacgccc
     7741 agcgtgccca ggctcatcgc cgtcgccacg atcagcccga ggccgaagcc cacgatcacg
     7801 gtcatcggca ggatgtccgc cgcgtacgaa ctgttcaggt ccaggctcgt catccacacc
     7861 aggccggccg ccgcgatcgc catgcccgag ggcaccacca gccgcggccc gatgcgcggt
     7921 acgaggacgt tggtggcgag cgtcgcggcg atcaccaggc cgccgaccat cggcagaaag
     7981 gcgacgccgg agtcgatcgg cgtgtagtcg aggcccgtct gcaggaagta cgtgaggaag
     8041 aggaagacgc cgaacatccc gcccgcggag atcagcatgc cgaggtagga cgcgccgcgg
     8101 ttccggtcgg tgacgatgcg cgtgggcagc agggggtgct ggctccgggt cgaccaccag
     8161 gcgaacgccg tgagcagcac gccgccggcg atcagcagcc cccaggtggc cggcgcgccc
     8221 cagtcctggt gctcggcgtt ggagaagccg tagacgacgc agaagaggcc ggcggtgacc
     8281 agggccgtgc cgggcacgtc gagcgtgacg ctccggtccc gtgccgtacg ggtcagcagc
     8341 gcggaggcga agccgaaggc gacgacggcg agggccacgt tcacgtacag cgtccagcgc
     8401 cagtccaggt actcggtgag caccccgccg agcagcaggc cgatggcgcc gcccgcgccg
     8461 gacaccgcgc cgtagacgct gaacgccttc gcccgctcgc ccgggtcggt gaacgtcgtc
     8521 gtcagcagcg acagcgcgga cggggcgagg agcgcgccgg aggcgccctg gaaggcgcgg
     8581 gcgaggatga gcatgtcgaa gctgacggcg gcgcccgcca cggcggacgc ggcggcgaag
     8641 ccgacgagac cgacgaggaa ggtgaccttg cggccgacaa ggtcggcgat gcggccgccg
     8701 aggagcagga ggctgccgaa ggccagcgag tacgcggtga cgacccactg ccggtcgccg
     8761 ttggtgaagc cgaggtcgga ctgggcggac ggcagggcga tgttcacgat ggtcacgtcg
     8821 aggacgacca tcaactgggc caggccgagg acgccgagga tcagccaccg atggcggtgg
     8881 gcgcggtcgt cttggggcat gacggcgacg gcgggcgggc cggtttcgcc ggcgggaccg
     8941 ctgccggcta cggcgtcggt aggggacatg gcaggctccg tgtggggggg atcgggtact
     9001 cggaggaccg gactgggctc gtacgggtac ggcgtagggg tatgtggccg tcgcggtacg
     9061 gagccctgcc cggcggcgtc gggcccgcga ggcgggcgta cggcggccgg agggaccgga
     9121 gtgaccggcg aggggtggtg aagggcgtac ggctcaggag tgacgcagcg ccggcagcac
     9181 cacgaggtcg acgaagcgcg cgagatacgc ggaatcggcg aacgccccgt cgatcagcgg
     9241 gcgtatgacg accgcgccga agagcaactg cggcaggaac tcggccgcgc ccggctgccc
     9301 gggcagttcg ccgcgcgcca ccgcgcggtc gagcaggccg ctcaggtgcg tcaactcgta
     9361 gtccgcgagg gaggcgtgca gcgtcgcggc caggtccccg tcggtgagcg cggcgtggtg
     9421 tatcgccgcg atcagcgccg tgtccttctc cgcggtggtg gacaactctt cgacgaggct
     9481 gatcagatca ccgcgcagcg agccggtgtc gacggcgccg gggtccacgg gccggttggc
     9541 gatcatcgcg gcgacgacca tctccgcctt gctgtgccac tgccggtaca gggtcgcctt
     9601 gctgcaccgc gcgcgggtcg cgacgaggtc catcgacagc gcctcgtacc ccgactcgcg
     9661 cagcacgccc agcaccgctt cgagcagctc acgctcgcgc tcgggggtca tgcggggccg
     9721 gcggatccgg gcgtcggggg cctggccgtg gagctggccg acgggtctgc cgggcatgac
     9781 gggcgatcct tttcgtacgg aacggtttcg tacggcccac gctagatcgc gaccgggaga
     9841 aacgcaaccg tttcacccag tgacttcgcg agtggatccc tcatcggcca atcccccttt
     9901 tatgcctact ctttcgagcg attgccgcac tcggcgcaga tgcctagcgt cgaagtatga
     9961 cgatctcctc gccgaccgcc gcggaggccg ggtgccgcgc atgaccggag cacccgcaga
    10021 agcactccgc gccctcctcc ccctcggccc caccggtctc ggcaccgccg ccgcgcaccc
    10081 gctcgccggg tacgtaccgg aggccgtccc gaagcccgag gcggagcccc ccgcccgtac
    10141 gaagccccgg ccggagccgg catccggcgc cggacccggc accgactcgg accccggctc
    10201 cgcatccgcc gcggggcccg aggccggcac cgcgccaccg cccgacggca gcggggagcg
    10261 cggcggcctg cggatcccgc cgctgtactg ccccgacgcc ctgcgcaacg accccgcgct
    10321 cggggacgag gtcaacgagc ggctggtcgc gtgggcggaa gagatcggca tcttcaccgg
    10381 ccgcatcgag cgcctgcgct cccaccagtt cggccgcctc ttcatgctcg cgcaccccga
    10441 ctgcgacgac cccgaccggc tgctggccgc cgccaagtgc ggcctgtccg agtggtccgt
    10501 cgacgaccac tgggtggacg agggcgagga ccccgatccc gccctgctcg gcgagcggat
    10561 ggcgctggcg cacgccgtca tcgaccccgt ccggctcccc gcgcgctaca tgccgcagtt
    10621 cgaggagacc gtccagcgcg agccggtgct ccgcgcgttc cgctccgccc tcgcgcacct
    10681 ctcgcggtac gcgagcccca cccaggtcgc ccggctgcgg cacgagttgg ccgtcatgtt
    10741 cgtcgggtac ggccaggagg ccgagtggcg ctcctcggcg cgcacccccg cggtgtggga
    10801 gtacctgctc caccgctacg agaacgcgtt cttcccctgc atggtcctcg tggaccccgt
    10861 cagcgggtac gagctgccgc cggacgagtt cgccgacgcc cgggtccgcc gcacgtacct
    10921 ctacgccggc accgccagcg tgctcctcaa cgacctgtac tcgatgggaa aggaagaccc
    10981 cacggacacc aacctgccca atctgatcgc cgcagaagaa ggctgcaccc tccaggaggc
    11041 cgtggaccgg acggccctca tccacgacga gctgatgcac acctacgaga tggaggccgc
    11101 ggccctcacc gccgccggct ccccgcagct cggccgcttc ctggccgggg tgtgggcgtg
    11161 gatgggcggc tgcaaggagt ggcacgccac cagcgcccgc taccagaccg cctgacccgc
    11221 cgggccgatc cgcctgccgg cccggaccgc ctggccggac cggcataccc ggcagacccg
    11281 gcccgttcat ccctccgacg cacccgcagg tacgcctgac gggccacgcg tccgcaccgg
    11341 cacgtccccg accaccacgc ctcaccagct ccagcacgct cagcacgccc tcagaaggag
    11401 aacgaccatg gcggcagccg ccgacacgaa cgtcctcacc agcccgtacc agcactccat
    11461 cgccgactac tggaaccggg agaaggaccc ggtcaacctc aagctcggcg acgtcagcgg
    11521 gacgtaccac caccactacg gcatcggcga ggtcgaccag tccgtgctgg cgggcccgga
    11581 ggagaccagg gaagagcgga tcatcgcgga gatgcaccgc ctggagaccg cacaggccac
    11641 cctcctcctg gaccacctcg gcgagcccga ccgcggcgcc cggctgctgg acgccggctc
    11701 cggccggggc ggcacgagct ttatggcgca cgaacgattc ggctgccgcg tcgacggcat
    11761 ctccatctcg cagtcgcagg tctccttcgc caacgaccag gtgcagcgcc gcgggctggg
    11821 gagcgcggtg cggttccacc tgaagaacat gctcgacacg ggcttcgaga cgggtgcgtt
    11881 ccgcgggatc tggaacaacg agagcacgat gtacgtggag ctggcgcagc tcttcaagga
    11941 gcacgcgcgg ctgctcgcgc gcggcggccg gtacgtcacc atcaccggct gctacaacga
    12001 cgcctacggg ctgccgtccc gcgccgtcag ccagatcaac gcgcactaca tctgcaacgt
    12061 ccacccgcgg tcgacgtact tcaaggagct ggtcgcgaac cggctggtgc ccgcggaggt
    12121 catcgacctg accgaggcga cgatcccgta ctgggagctg cgggccaagt cctccgtcgc
    12181 caccgggatc gaggaggtgt tcctcacggc gtaccgcagc gggagcttcc agtacctgct
    12241 gatcgccgcg gaccgggtct gaccggatcc gctcggctcc cggtgggcgc ccgcggccgg
    12301 cgggacccac cggggcggcc cggcgccggt ggccgcgtcc gcaccggtgc cgggttcggg
    12361 gtttcgggtt tcggggttcg ggttcggtaa aggggcgggt aaaaggagat cggccgctca
    12421 cggggtgcgt gagaggctgg cgtacgtgcg catcggggtg ctgggtccgc tggaggtggc
    12481 ggtcggcggg gtgccggtgg agatcgccgg cggccggctc cgcgcgctgc tcgtacggct
    12541 cgcgctcgac cccggccggt acgtcggcac gacgctgctc gccgacggcc tctggggcga
    12601 cgacgccccc gccgaccccg gcaacgcgct gcagtccctc gtctcccggc tgcgccgcgc
    12661 gctcggccgg tccgacgtcc tcgcgtacgg gcccgccggc taccggctcg cactgccgcc
    12721 ggaggcggtg gacgccgtgc gcttcgagcg gcaggcgcac gccgggcgcg aggcgctggc
    12781 ggcgggcgac gccccggcgg cgcgccggct gctggaggag gcgctgacgc tgtggcgcgg
    12841 gcccgcgctc gcggacgtgg cggacgcgcc gttcgcggcg gcgcccgcgc accggctgga
    12901 ggagctgcgg ctggaggcca ccgaggaccg catcgaggcg ggtctggcgg agggcggtcc
    12961 gggcggcgcc cggcccggtg ccgcggttcc ggagctggag gcgctgacgg tggcgcaccc
    13021 gctgcgcgag cgcccgcgcg cgctgctgat gcgcgcgctc tacgcgacgg ggcggcagcc
    13081 ggaggcgctg ggggcgtacg aggagtaccg cacgctgctc gcggaggagc tgggcgcgga
    13141 cccgtcggag gccctgcggg agctgcacgt ggcggtgctg cggggcggga cgccggggcg
    13201 gggcggcgca agcggcccgt acagtacgag acccggcgcc accggcgatc cgtaccgtac
    13261 gaagcccggc accgggcccg gtgcccccga cgaccccccg cccccggtcc gtaccaacct
    13321 gcgcgccgcc ctcaccagct tcgtcggccg cgacggcgaa ctgcgccgcg tgcgcgccct
    13381 cctcggcggc tcgcggctcg tcaccctcac ggggcccggc ggcgcgggca agacccggct
    13441 cgccaccacc gcagcggaag cgctcctcga cgactcaccc ggcggcgtgt ggctcgtcga
    13501 actcgcgccc gtgaccggcg gcgacgacgt cccgttcgcc gtactcggcg cgctcggcca
    13561 gcgcgagacc gccgtgctcg acaaccgcca cctgcccccg cgcgacgtgc tgacccggct
    13621 caccgacacc ctcgccgccg cgcccaccac cctcgtgctc gacaactgcg agcacgtcgt
    13681 ctcggccgcc gcccacctcg ccgaccacct gctgcgccgc tgccccgagc tgcgcgtgct
    13741 cgcgaccagc cgcgagccgc tgggcatcga cggcgaggcg ctgtgccccg tcccgccgct
    13801 gagcctgccc ccgcgggacg ccgaggacgg ccgggacgcc cgcgacgggc agggcgagca
    13861 cgccaccggc gcggcggtgc ggctcttcgc cgaccgcgcc cgcgccgccc gccccgactt
    13921 cgccgtcggc cccgccaacg ccgccgccgt cgccgagatc tgccgccgcc tcgacggcct
    13981 gccgctggcc atcgaactgg ccgccgcccg gctgcgttcg ctccccgtcg agcaggtcgc
    14041 cgcccggctg gacaaccggt tccggctgct gaccaccggc agcaggaccg cgctgccccg
    14101 gcaccgtacg ctccaggccg tcgtcgcctg gagctgggag ctgctggggg acgaggaacg
    14161 gcggctcgcg gagtggctgt cggtgttccc gggcggcgcg acgcccgaat ccgtcgcggg
    14221 cgtgtgcggc atggacgtcg tcaccgcgct cgacctgctc gcggccctcg ccgacaagtc
    14281 cctgctgcag atcgcggaag caccgcaggg cgcgcatgcc gagccgagcg ccggtccgcg
    14341 ctaccgcatg ctggagacca tccgcgagtt cggccgcgac cgcctcgccg aggccggcga
    14401 cctcgaccgc gtacgtgccg cgcacgccgc ccacttcctc cggctcgccg agaccgcgga
    14461 cccgcacgtg cgcggccacg agcagctcgg ctggatcgcc ctcctcgacg ccgagcacga
    14521 caacctcctc gcggccctgc gccacgccat cgacgccggg gacgccgtga ccgccgtccg
    14581 gctggtcgcc gccctcggca tctactggat gatcctcggc caccacagcg aggccgccga
    14641 ctggctccgc ctcgcgctcg ccgtccccgg cgacccgccc ctcgaaccgc acgcggtcgc
    14701 cctcggcttc tccctcatca actccgcgac gagcggcggc atcgagccgg acccggcggc
    14761 cctggaggag ctgacggcgc tggccgcacg ggtcgatccg atgggcgggc acccgatgct
    14821 ggccgtgctg gagccgggca tcgcggtgtt cacggacgac gacgcgcgcg ggctcgccgc
    14881 gatcgacgag cggctgggcc acccggaccc gtggacgcgg gcgctgctgc ggatgatccg
    14941 ggcggcgttc cgggagaacc gggggtacgc gccgggtctc gaggaggacc tggaggcggc
    15001 cgcggcggag ttccgcgagg tcggcgaccg gtgggggctg gcgatggcgc tccaccaact
    15061 cggcgagtac cgggcgctgc tgggggacgc ggagcgggcg cgggcggggt tcgaggaggc
    15121 gctgcggctc atgggcgagg tgcatgccga ggacgacgtg gggcagttgc gcacccggct
    15181 cgcgcagctc gaagcggcgc aggggcgtac ggaggaggca cgcgcggagc tgcaccgcgt
    15241 gttgggtgcg gcggtgcgcg aggggcgctc gcatgtcgcg gcgctgtgcc gggacgtcct
    15301 gggcgacctc gcgcgccggg cgggcgaggc ggacgaggcg gcgcggtggt acggggaggc
    15361 gctggcgacg ctgcggcggg gcggggtggc agtgccgcag atcgaggcga tcgtacggac
    15421 ggggcgggcg ctgctggcgt gcgtacgcgg agacccggcc ggtgcgcgta cggagctggc
    15481 gacggcgctc ggcgtggcgg tcggggtgaa ggacatgccg gtggtcgcga tggtcggggt
    15541 cggcgtggcg acgctggccg cggagtacgg ggaaacggcg acggggctga cggaggagga
    15601 gcacacgggc gcggagttcg cccgcgccgc cgaactgctc ggcgccgccg actccgtccg
    15661 cggggtcggc gacgtcgcgc tgccggacgc cgccgacctg gccgcccggc tgcgccgcgc
    15721 gctcggcgcg gagttcgagc cggcccgggc ccgcggcgcc gccctcaagc agggcgacgc
    15781 catcgaactg ctccgcgcgt acctggccga cacccccggc tgtccctagg tgcgccgcag
    15841 ataggcccgt acggccagcg ggaagaacac cgccagcacc cccgcgctcc acagcaccga
    15901 ctccagcacc ggccccgcga cagggccctc gaccatcagc ccccgcgcgg cctccatcac
    15961 gcccgtcacc gggttcacgt cgacccacgt ctccagccag ccggggagag tgtcggtggg
    16021 caccaatacg ttggtgccga aggtcagcgg gaacatcgcc atgaaaccca cgccctgcac
    16081 cgcccccggc tcccgcacca gcatcccgat cagcacgaac acccacgaga ggcagaacac
    16141 gaagagcatc acgagcagac aggccgccag ggccggcagc agtccggtcc cgacccggaa
    16201 gcccacggcg tagccgaagc cgagttgcac cacgatcagg acgacgaacc ggatcaggtc
    16261 gccgagcacc gagccgatca gcggcgcgga gcgcgcgatg ggcatgctcc ggaagcggtc
    16321 gaagacgccc ttcttgatgt cgtcgttgag gttgatgccg gtctggacgg aggcgaaggc
    16381 cgtgttcatg accatcaacg ccggcagcag ggtctgcaga tacgcgtgcg tcgagcccgc
    16441 gacggcaccg ccgagcaggt acaggaacat gacgaggaag aggatcggct gaagcgtcac
    16501 gtcgatcagt tgctcgggcg tgcgcctggt cttgaccagg ctgcggccgg cgagcgcgac
    16561 gctgtgccgg acgagcgcga agggccgggc ggcgccctcg cggcgggacg gcaccgcggt
    16621 ccgctcgggg gcggtgagcg tggtcatcgg acggcctcct cggtcttcgg cgtacgggcc
    16681 gcgcccgctg tcccggtgac ggatccggcc ggggcggccg tgccgtggcc ggtgagggtg
    16741 aagaagacgt cgtccaggtc gggcagccgc agcgacagct cggccaccgc gatcccggcc
    16801 tcgtcgaggc ggcgtacggc cgccgtgagc atgccgtcgt cggcgacggg gacggtcagc
    16861 gtgccgcgcg tcggcgactc gggctgcgtg ccggccaccg ccgcgaggat cccggccgcg
    16921 tccagcagcc gcgccgggtc cagcgggcgc aggtcgaggt ggcggccgcc gacgcgccgc
    16981 ttcagctcgg ccggggtgcc gtgggcgatg acccggccgt ggtcgatgac ggagatctcg
    17041 tcggcgagcg cgtccgcctc ctccaggtac tgggtggtga gcagcacggt cacgccgtcc
    17101 ccgacgagcg agcggacgat gccccagacg tcctcgcggc gcaccgggtc caggcccgtc
    17161 gtcggttcgt cgaggtagat gacgtcgggc cggccgacga gggaggcggc gaggtcgagg
    17221 cggcggcgca tgccgccgga gtacgtccgc acggggcggc cggcggcccc ggccagctcg
    17281 aagtgcgcca gcagctcgcg ggcgcgggcc cgggcggcgc cggtgcgcat gtcgaggagg
    17341 cgcccgatga gcacgaggtt ctcggtgccg gtcaggtcct cgtccacgga ggcgtactgg
    17401 ccggtgagcc cgatgagccg gcgtacctct ccggcgtcgc ggacgacgtc gaggccgccg
    17461 acggccgccg tgccctcgtc ggggcggagg agggtggcga ggatgcgtac ggcggtggtc
    17521 ttgccggcgc cgttggggcc gaggacgccg aggacggtgc cctgccgggc cgcgaggtcg
    17581 ataccggcca gcgcggtggt cgcgccgaac cgtttgacca ggccctcggc cctgaatgcg
    17641 taggtcatgc ggtgtctcct tctcggtctg cgggaaggag cgtgccgagg accgctggca
    17701 cggcgcgcac aggacgctgt cacgccgcca cggtggcgtt atgtccggtt tatcggattg
    17761 caggaggtgc gttcgctgag agcggaatag ggccgtacgg gtcaccccac acgccgtgca
    17821 cgacggcgcc ccgaccggct cgttgagcgc ccgcccgggc ctccgcgcgc aactacgcgc
    17881 ccccgcgcaa ccccccgagc gcccgctgct gagcaccgga aaagtgccgc caatcggacc
    17941 cctgggctac ggttcacgct gcggtacgtc aaacttgtga ctgatcgcac tgttttactg
    18001 tccggcatca tggaaaacga cgggccgacc gagcaacggc ccgcggtcgc ccgggcaccc
    18061 cgacaaggag agaactcgtg gacgacgttc tgcggcgcgc gcccctcttc gccgcgctcg
    18121 acgacgagca ggccgcggag ctgcgtgcct ccatgaccga ggcgacgctg tcgcgcggtg
    18181 acgcgctctt ccacgagggc gagcccggcg accggctgta cgtcgtcacc gagggcaagg
    18241 tgaagctcca ccgcacctcc ccggacgggc gcgagaacat gctggccgtg ctcggccccg
    18301 gcgagctgat cggcgagctg tccctcttcg acccgggtcc gcgcacggcc accgcctcgg
    18361 cgctgaccga ggtcaagctg ctcggcctcg gccacggcga cctccagccc tggctgaacg
    18421 cccgccccga ggtcgcctcc gcgctgctgc gggcggtcgc ccgccggctg cggcgcacca
    18481 acgaccagat gtccgacctg gtcttctccg acgtcccggg ccgcgtcgcc cgcgccctgc
    18541 tggacctctc gcggcgcttc ggcgtccccg gggacgaggg catccacgtc gtgcacgacc
    18601 tgacgcagga ggagctggcc cagctcgtcg gcgcctcccg ggagacggtc aacaaggcgc
    18661 tggcggactt cgccagccgc ggctggctgc gcctggaggc gcgggccgtg atcctgctgg
    18721 acgtggagcg cctggcgaag cgctcgcgct gaccgcgggc cggcccggcc cggctacgtg
    18781 atcaggccgt gctccttcag atactcgagc tgggcccgca ccgacagctc cgccgcgggc
    18841 cacagcgtcc ggtccacgtc cgcgtacacg tgcgccacca cctccgccgc cgtgcggtgc
    18901 ccgttctcga ccgccgtctc gacctgcgcc agccgcgtcg cgcggtgggc caggtagaac
    18961 tccaccgcgc cctgggcgtc ctccagcacc ggcccgtggc ccggcagcac cgtcgagacg
    19021 ccgtcgtcca cggtgaggga ccgcagccgg cgcagcgagt cgagatagtc gccgagccgg
    19081 ccgtccggat gggcgaccat cgtcgtgccg cggccgagga tggtgtcgcc ggtgagcacg
    19141 gcgtcgtcgg ccggcaggtg gaagcagagc gagtccgccg tgtggcccgg cgtgggcacg
    19201 acccgcagct ccagcccggc gacggatatc acgtcccccg cggccagccc ctcgtcgccg
    19261 aggcgcagcg ccgggtccag ggcccgcacc ttcgtcccgg tcagctccgc gaagcgggcc
    19321 gcgccctcgg cgtggtccgc gtgcccgtgg gtgagcagcg tgagtgccac ccgcaggccc
    19381 gcccggtccg cggtgtccat gaccgccgcc agatggcctt cgtccagcgg cccggggtcg
    19441 atcaccacgg cccgcgcgga gtccggctcg gcgacgatcc acgtgttcgt accgtcgagg
    19501 gtcatgggcg aggcgttggg cgccagcacg cacgtcgcac gagcagtggc cggcccgctg
    19561 agcgccccgc cgcgcggctg tcctggcagc gccgccgcgt ccgtcacacg accacccccg
    19621 ccgtcctccc cgccgccgcc ctcatgacgg cagcctccgc gtgaactcct cgtgccccgg
    19681 ggcgctcagc accacgtcgt ccccctccat ccgggccttc accagcaccg ccgacagatc
    19741 ccgctccccg gccgcggcca gcgcctcggc cgccgacccg tactcccgca gcccgcgcag
    19801 catcgagatc gtcggcggca gcatcaccag ttcaccgcgc tcatacccct cggccgcctc
    19861 ggcgggcctg acccactccg cgcggtcggc ctccgtcgag gcgttccgcg tgcgctggcc
    19921 ctcggggagg gcggcgacga agaaccacgt gtcataccgc cgggtctcga actccggggt
    19981 tatccagcgc gcccaggcgc cgagcagatc ggtccgtacg accagaccgc ggcgggccag
    20041 gaagtcggcg aagcccagct cgcgggcgac cagcgccgcg cggtccgcct cccagtccgc
    20101 ccccgtggtg tccgccacga cctcggccgc cgaggccccg gccagcagca ccccggcctc
    20161 ctcgaacgtc tcccgcaccg ccgcgcagac caccgcctgc gcctccggct cggccacccc
    20221 cagccgcgcc gcccaccgcg cgggggccgg cccggcccag gccgccgcgg gcagcgggcg
    20281 ctcgtcgcgc ggatcgacgc cgccgcccgg gtaggcgtac gcacccgcgg cgaagggcat
    20341 ggaggtcttc cgccgcagca tgtacaccca cgggccgtcg ggggccatgc cgcgcagcag
    20401 cagcaccgtc gccgcgcgac gcggcgtgac gggcgtcagc tcgccgcggg cgagcgcgcg
    20461 gatgcgctcg gcgggcggaa tccaccgggg ctgcgctccg gccgcggcgt tcgcggcgtt
    20521 catttcggac atgacgggga gcctacgggc tgccgaggcc atgttcgagt gggcaacccc
    20581 agcctgtgga caaccgccgg tatgtggacg actccgggcc cgccggcccc atacccgccc
    20641 cggacgaacg tcccggacga acgtcccgga cgaacgcccc ggagcggcag cccctacccg
    20701 gccagctccg cctggaactc gatctccacg ggcgcgtcca gcggcagcac cgccaccccc
    20761 accgcgctcc gcgcgtgcac accggcctcg cccagcacct ggcccagcag ctcgctcgcc
    20821 ccgttgacca cacccggctg cgccgtgaag tccggcgccg aggcgacgaa gccgacgacc
    20881 ttcaccaccc gtacgacccg gtcgaggtcc cccgcgaccg acttgatcgc cgcgagcccg
    20941 ttcagcgcac accgcgcggc cagctccctg gcctcctccg gcgtgacctc cgccccgacc
    21001 ttcccggtca gcggcagcgt gccgtcgacc atcgggagct gccccgcggt gaacacgtac
    21061 ggcccgctgc gcaccgccgg cacgtacgac gccagcggcg gcaccacctc gggcaggctg
    21121 agccccagct ccgcgagctt ctcctcgacc cgccccgcca tcagctcttt tcccgcttca
    21181 gatacgccac gagctgctcg gagttgggcc cgggc
//
