LOCUS       NZ_RHGC01000010        11413 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig010, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000010
VERSION     NZ_RHGC01000010.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 206294)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 206294)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 160445
            Orig. end                         :: 171858
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000010.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11413
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="2"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11413
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11413
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6413](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6413)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            72..791
                     /gene="hemQ"
                     /locus_tag="EJ355_RS35755"
     CDS             72..791
                     /EC_number="1.3.98.5"
                     /codon_start=1
                     /gene="hemQ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643864.1"
                     /locus_tag="EJ355_RS35755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hydrogen peroxide-dependent heme synthase"
                     /protein_id="WP_087886225.1"
                     /transl_table=11
                     /translation="MSDDAPAKIPNAGKKAKDLNEVIRYTLWSVFKLRDVLPESRLGYA
                     DEVQELFDKLAARDITVRGTYDVSGLRADADVMIWWHAETADELQEAYNLFRRTKLGRA
                     LEPVWSNMALHRPAEFNKSHIPAFLADETPRDYVSVYPFVRSYDWYLLPDEDRRRMLKD
                     HGMMARGYPDVRANTVASFSLGDYEWLLAFEADELYRIVDLMRHLRASEARMHVREEVP
                     FFTGRRKSVADLVAGLA"
     gene            959..1342
                     /locus_tag="EJ355_RS35760"
     CDS             959..1342
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970478.1"
                     /locus_tag="EJ355_RS35760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RNHCP domain-containing protein"
                     /protein_id="WP_030360273.1"
                     /transl_table=11
                     /translation="MSQRSRNTSRRARTEARAQSFRCLHCGLDVSMTAPGTDHRNHCPN
                     CLWSRHLDDTPGDRAADCGARMEPLAISVRGDGEWVLVHRCTHCGVLHANRTAGDDNVL
                     PLTRLAVRPLAQSPFPLERLGML"
     gene            complement(1445..3115)
                     /locus_tag="EJ355_RS35765"
     CDS             complement(1445..3115)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (129-502). E-value:
                     6.3e-21. Score: 67.0. Matches aSDomain:
                     nrpspksdomains_EJ355_RS35765_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643866.1"
                     /locus_tag="EJ355_RS35765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_087886226.1"
                     /sec_met_domain="PF00561 (E-value: 3.2e-26, bitscore: 85.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAPATAAARYRAARTVGTIGSLVLTALAAAPASSAATTSFPGAP
                     GAPGVPATPSPETLGTALAAQRAQTTGIDFGACPQVENLPPSVECGTVAVPLDYAHPDG
                     KQIRLTVSRVEATGKSGRAVVSRQGALVFNPGGPGASGMYFPMVGPMPEWKRVAAAYDL
                     VGYAPRGVGRSAPLSCQDPKQFTKAPTNSPTHPDASYKAERIAQAKAYARGCARNAGPD
                     LRHYTTLNNARDLDVLRAALGERKLTFMGASYGTYIGSVYATLFPGHVRRMVFDSAVNP
                     DPDQIWYANNLDQSFAFERRWADFRTWVAKHHKAYGLGTTPQEVQRSYESVRAELTHKP
                     AGGKVGSSQLRAAFLRAAYYDDYWPMRATALSQYLKGNPKPLIQQAAPHPAAAAEDENG
                     NAVYTAVECNDAAWPTDFPTWDRDNSALARLAPFETWDNAWMNLPCAYWPEPRQRALDV
                     RTAPGALPPTLILAAERDAATPYEGALELHHRLAGSVLVTEKDAGTHGIAGGPNACVNG
                     HVEAYLLEGELPARRASCAPHPEPKPLSGARAAELPKPL"
     aSDomain        complement(1610..2728)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS35765_Abhydrolase_1.1"
                     /evalue="6.30E-21"
                     /label="EJ355_RS35765_Abhydrolase_1.1"
                     /locus_tag="EJ355_RS35765"
                     /protein_end="502"
                     /protein_start="129"
                     /score="67.0"
                     /tool="antismash"
                     /translation="ALVFNPGGPGASGMYFPMVGPMPEWKRVAAAYDLVGYAPRGVGRS
                     APLSCQDPKQFTKAPTNSPTHPDASYKAERIAQAKAYARGCARNAGPDLRHYTTLNNAR
                     DLDVLRAALGERKLTFMGASYGTYIGSVYATLFPGHVRRMVFDSAVNPDPDQIWYANNL
                     DQSFAFERRWADFRTWVAKHHKAYGLGTTPQEVQRSYESVRAELTHKPAGGKVGSSQLR
                     AAFLRAAYYDDYWPMRATALSQYLKGNPKPLIQQAAPHPAAAAEDENGNAVYTAVECND
                     AAWPTDFPTWDRDNSALARLAPFETWDNAWMNLPCAYWPEPRQRALDVRTAPGALPPTL
                     ILAAERDAATPYEGALELHHRLAGSVLVTEKDA"
     misc_feature    complement(3161..3177)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.78"
                     /tool="antismash"
     misc_feature    complement(3163..3177)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.39"
                     /tool="antismash"
     gene            complement(3276..4046)
                     /locus_tag="EJ355_RS35770"
     CDS             complement(3276..4046)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020122142.1"
                     /locus_tag="EJ355_RS35770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_087886227.1"
                     /transl_table=11
                     /translation="MFWVPLLLLACALAALSCGRLCVAAVRAAASEARGAHEGRHLTLY
                     EAAFLSGGPGRVVDVALLSMARRRRLLLAHTGWATVVDPVAGDDLERSVLGAIGPAGQS
                     RIAPVRTAAAAGDGVRALADRLVAAGLAVPDGMWSGIAGAARQVRAAAVAVVVLGACAT
                     LLPAEGREGELPVAVWFALPFFLTVSCLAIARFEVPTTRWASPAGRRLLGALPSRDDLT
                     SVAVRGLRALEDPALRAALSHRDPNLDGYRETRP"
     misc_feature    4058..4075
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.84"
                     /tool="antismash"
     gene            complement(4143..4898)
                     /locus_tag="EJ355_RS35775"
     CDS             complement(4143..4898)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983659.1"
                     /locus_tag="EJ355_RS35775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_087886228.1"
                     /transl_table=11
                     /translation="MRSRIISGSGLVLTGLVVTLAALVYPVWSYEDRSGTGLDALTSQT
                     VSTDYGPLSALDRDFVTKVRLAGLWELPAGQQAGERGTTRAVHVAGKHLVEGHAFLDAR
                     VREVAAALRLELPSQPSAQQRRWLAELSAERGTAYDVKFANILRRAHGKVFSLVAEVRA
                     TTRNSQVRALADDANTTVLDHIKVLEGTGLVDFDGLARDAATATTPPPARSPAPPGPQD
                     SPPPAAPAAPNPTYSLPPAVSRPAPGLRD"
     gene            complement(5001..6413)
                     /locus_tag="EJ355_RS35780"
     CDS             complement(5001..6413)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643869.1"
                     /locus_tag="EJ355_RS35780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_125264690.1"
                     /sec_met_domain="DUF692 (E-value: 4.1e-98, bitscore: 321.1,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLGTGIGWRPEIADAVERMPGVDWVEAVAENVCPGHLPDSLLR
                     LRERGVTVVPHGVSLGLGGAERPDEARLTALAERAEALGSPLVTEHIAFVRAGGALTAS
                     PHLEAGHLLPVPRTRDALAVLCENVRIAQDALPVPLAVENIAALISWPGEEMTEGQFLY
                     ELVERTGVRLLIDVANLHTNHVNRGEDPSRALDELPVEAIAYVHVAGGFERDGVWHDSH
                     AHAVPQPVLDILADLASRTRPPGVLLERDENFPEEGELERELTAIRETVATATATATAT
                     ATAGSAAAAPAPDPDPAPDPADGPVPGPAATPEARQRVALAQAAFLSALVAGTPAPEGF
                     DGARLRVQSRALGAKRADVVAKVAPELPWIIGESYRADFLGYARTRPMTGGYRQDALDF
                     AEHLLLAGRPEDAAARGELTAWWLERSGPKPLDGHPLTRWLRTRTARLALRRARRRAPG
                     HAGVDADPAPAT"
     gene            complement(6579..7346)
                     /locus_tag="EJ355_RS35785"
     CDS             complement(6579..7346)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643870.1"
                     /locus_tag="EJ355_RS35785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4142 domain-containing protein"
                     /protein_id="WP_087886230.1"
                     /transl_table=11
                     /translation="MGRINGTALIIAALVVTVGALAFPVWSYADRSGTGEANLNAGSVS
                     TRWGPLSATDRDFIVKVRLAGLWELPAGQQAVERAPSKAIKEAGDHLIVGHTDLDERVR
                     GIAAQLGVELPNQPTTQQQGWLRELTDATGEDYQRKFANLLRVAHGKVFSLIAQVRDTT
                     RNSLVRQLASDANQTVLDHITVLEGTGYVDFDAIANDTAGKSTASPTGPPPPDGNTPPQ
                     PEPAGPTGDVSGTSRPSPGAPGTVNTDRPEPQM"
     misc_feature    7463..7478
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     gene            7581..8024
                     /locus_tag="EJ355_RS35790"
     CDS             7581..8024
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643871.1"
                     /locus_tag="EJ355_RS35790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5959 family protein"
                     /protein_id="WP_087886231.1"
                     /transl_table=11
                     /translation="MAPAEPIDLIRLEGEDNSVVVRITGKRPAPGRPGIDELVGEILVD
                     TAFVRGTLATSVSPEDLTEWRETLDALDGGDDSTWREGGRAPELLVELDPDGERAHVTV
                     ADHAMSLTTVTATVTLTDEWFDEAYDRLDATLRAWPVEGALQG"
     misc_feature    complement(7605..7618)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.84"
                     /tool="antismash"
     misc_feature    8031..8043
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.39"
                     /tool="antismash"
     misc_feature    complement(8081..8098)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.15"
                     /tool="antismash"
     misc_feature    complement(8130..8144)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.21"
                     /tool="antismash"
     misc_feature    8131..8142
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            8135..>8331
                     /locus_tag="EJ355_RS39090"
     CDS             8135..>8331
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS39090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_193560827.1"
                     /transl_table=11
                     /translation="MNASTIDTDAERGGTGTAAVHTGTATRSTLFAAAAVLTLGVALTA
                     CGDGDKPRPAVTVTKTVTAGG"
     assembly_gap    8332..8341
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            <8342..8755
                     /locus_tag="EJ355_RS35795"
                     /pseudo=""
     CDS             <8342..8755
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656662.1"
                     /locus_tag="EJ355_RS35795"
                     /note="incomplete; too short partial abutting assembly gap;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DUF5067 domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="GAAESKDDTLGLTGTAVYENKNEVSLSSFSRGVSGPYASPERTPY
                     VKFTLKLKNGTDKVIDMSALSVLCQYGHEAKDGEQIFDSENGLDGPPQTHLRPGRSITA
                     TLGCELPTSQKHLQIEVTPDFETEAAIFSGKVK"
     gene            complement(8798..9613)
                     /locus_tag="EJ355_RS35800"
     CDS             complement(8798..9613)
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007445276.1"
                     /locus_tag="EJ355_RS35800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="peptidyl-tRNA hydrolase"
                     /protein_id="WP_125264692.1"
                     /transl_table=11
                     /translation="MTSNAPRPDHSPTTRAPEAAQPSQAARYAQGTPAAGGSAPSSPFR
                     VERTPRDEAPQFVLPLVARIERAAPPARTDALETAARAVLTILSDERALGEGQWAQVMR
                     DWQDARIRKVVRRARGAEWRRAEALPGITVTGKSAEVRVYPPVPLDGWPKDLARLQVSG
                     TDLDDPEPPRDADPSTPVLWLNPDVGMSAGKAMAQAGHGAQLAWWDLSAPARTAWRDAG
                     FPLSVRTAPASRWPELTTSGLPVVRDAGFTEIAPGSCTVVADHPALRRP"
     gene            complement(9650..9835)
                     /locus_tag="EJ355_RS35805"
     CDS             complement(9650..9835)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020125244.1"
                     /locus_tag="EJ355_RS35805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_087886233.1"
                     /transl_table=11
                     /translation="MADDDEYCAPAPATGPRPAEGPPFAECVLCRKPTEYPESHRGATL
                     CPVCEWQEAQRTACSG"
     gene            complement(10001..10885)
                     /locus_tag="EJ355_RS35810"
     CDS             complement(10001..10885)
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657146.1"
                     /locus_tag="EJ355_RS35810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="polysaccharide deacetylase family protein"
                     /protein_id="WP_087886234.1"
                     /transl_table=11
                     /translation="MITRARQRAARASLAALAAAALTALSACASPSTPTRPHSPAPHHS
                     PQKAAPPTLAPGPQGLTPVFKNAPRAKQGAPTVALTFDADMTAGQGPRARAGERFDNPA
                     LVDTLRRLDVPATFFMTGRWAEEYPAQARAIGRDPLFEVANHSYSHYSFTRDCYGLPTV
                     APHRMRADVERAFAAFRRAGVEHPVPYFRFPGGCYDQRALRALAPAGVTAVQWDVVGGD
                     AFATDPRAVARQVLDGVRPGSVVVLHCTRSAAPATERALRTIVPKLRERGFRFVRVSEQ
                     IGAARAPKEGRAA"
ORIGIN
        1 cctttccgcc gtgcgcgagc tcaccgccaa cccggtgcag agcctgcacg gcggcgcggg
       61 agaatagccg catgagtgac gacgcccccg ccaagatccc gaacgccggc aagaaggcca
      121 aggacctcaa cgaggtcatc cgctacaccc tgtggtccgt cttcaaactg cgcgacgtcc
      181 tgcccgagag ccgcctcggg tacgccgacg aggtccagga gctgttcgac aagctcgctg
      241 cccgggacat caccgtccgc ggcacctacg acgtgtccgg cctgcgcgcc gacgccgacg
      301 tcatgatctg gtggcacgcg gagaccgccg acgagctcca ggaggcgtac aacctcttcc
      361 ggcgcaccaa gctcggccgc gccctggagc cggtctggtc gaacatggcg ctgcaccgcc
      421 ccgccgagtt caacaagtcg cacatcccgg cgttcctcgc cgacgagacg ccccgcgact
      481 acgtctcggt gtaccccttc gtgcgctcct acgactggta cctgctgccc gacgaggacc
      541 gccgccgcat gctcaaggac cacggcatga tggcccgcgg ctaccccgac gtgcgcgcca
      601 acacggtcgc ctcgttctcc ctcggcgact acgaatggct gctcgccttc gaggccgacg
      661 agctgtaccg catcgtcgac ctcatgcggc acctgcgtgc ctccgaggcc cgcatgcacg
      721 tccgcgagga ggtcccgttc ttcaccggcc gccgcaagtc cgtggcggat ctggtggcgg
      781 gtctggcgta gtcggtaatt cggttgccgc gcccgcgcgg cacgggtttc atcgagaggt
      841 cgggccgact ggggcccggc ctctcgtgcg tggacagaaa gccggtgttg tatgcccagg
      901 gccctgcgga atctctcgac ttcaccccat tccgcatcgc tcaggagtcc tctctcccat
      961 gtctcagagg tcacgcaaca cctcccggcg ggcgcgcact gaagcacgcg cccagtcctt
     1021 ccgctgcctc cactgcggcc tcgacgtctc gatgaccgca cccggcaccg accaccgcaa
     1081 tcactgtccg aactgcctct ggagccgtca cctcgacgac acccccggcg accgggcggc
     1141 ggactgcgga gccaggatgg aacccctcgc catatccgtc agaggagacg gcgagtgggt
     1201 cctcgtccat cgctgcacgc actgcggcgt cctgcacgcg aaccgcaccg cgggcgacga
     1261 caacgtcttg ccgctgaccc ggctggcggt gcggcctctg gcgcagtcgc ccttcccgct
     1321 ggagaggctc ggcatgctct gagtccggca tgttctgagt ccggcatccg cgggtccgtt
     1381 gtggctggtc gcgcccgcgc ggcggagccg cacagggata cggccccgcg ccccttcggg
     1441 cgctctacag cggcttgggg agttccgcgg cccgcgcccc cgacagcggc ttcggctccg
     1501 ggtgcggcgc gcacgacgcg cgtcgcgccg ggagttcgcc ctccaggaga tacgcctcca
     1561 cgtggccgtt gacgcacgcg ttcgggccgc ccgcgatgcc gtgcgtgccc gcgtccttct
     1621 cggtcaccag gaccgaaccc gcgagccggt ggtgcagttc gagagcgccc tcgtacggcg
     1681 tcgccgcgtc ccgctcggcg gccaggatca gggtcggcgg cagggcgccc ggggcggtgc
     1741 gcacgtcgag ggcccgctgg cgcggctcgg gccagtaggc gcacggcagg ttcatccagg
     1801 cgttgtccca ggtctcgaac ggggcgaggc gcgcgagggc ggagttgtcg cggtcccagg
     1861 tggggaagtc ggtgggccag gccgcgtcgt tgcactcgac ggccgtgtag acggcgttgc
     1921 cgttctcgtc ctcggcggcc gccgccgggt gcggcgcggc ctgctggatc agcggcttcg
     1981 ggttgccctt caggtactgc gacagggctg tcgcccgcat cggccagtag tcgtcgtagt
     2041 acgcggcccg caggaacgcc gcccgcagct gcgacgagcc gaccttgccg ccggcgggct
     2101 tgtgcgtcag ctcggcgcgg acgctctcgt aggagcgctg cacctcctgc ggggtcgtgc
     2161 cgaggccgta cgccttgtgg tgcttggcga cccaggtgcg gaagtccgcc cagcggcgct
     2221 cgaaggcgaa ggactggtcg aggttgttgg cgtaccagat ctggtccggg tccgggttga
     2281 ccgccgagtc gaagaccatg cggcgcacat ggccggggaa cagcgtcgcg tagacggagc
     2341 cgatgtaggt gccgtacgag gcgcccatga acgtcagctt ccgctcgccg agcgcggcgc
     2401 gcaggacgtc caggtcacgg gcgttgttca gggtggtgta gtggcgcagg tccgggcccg
     2461 cgttccgggc gcagccgcgc gcgtacgcct tcgcctgcgc gatccgctcc gccttgtacg
     2521 aggcgtcggg gtgcgtcggc gagttggtgg gcgccttggt gaactgcttc gggtcctggc
     2581 aggacagcgg cgcggagcgg ccgacgccgc gcggcgcgta gccgacgagg tcgtacgccg
     2641 ccgcgacgcg cttccactcc ggcatcgggc cgaccatcgg gaagtacatg ccggacgcgc
     2701 ccgggccgcc cgggttgaag accagcgcgc cctgccgcga caccacggcc cgccccgact
     2761 tcccggtggc ctcgacgcgg ctgacggtca gtcggatctg cttgccgtcg gggtgggcgt
     2821 agtcgagggg gacggcgacc gtgccgcact ccacggacgg cggcaggttc tccacctgcg
     2881 ggcaggcgcc gaagtcgatg ccggtggtct gggcgcgctg ggcggcgagc gcggtgccga
     2941 gggtctcggg ggagggggtg gcggggacac cgggggcacc gggggcgccg gggaaggagg
     3001 tggtggcggc gctgctcgcg ggggccgcgg cgagggcggt caggacgagg gagccgatgg
     3061 ttccgacggt tctggcggct ctgtaccggg cggcggctgt tgctggtgct ctcatcgctg
     3121 ttctgtgtcc ctttcgcggc gcgggcccaa gtgatcgcgt aaatcgcaaa atcacaacaa
     3181 aagggatatt cagttcgaag agtggcaaag tccagcaccg gcccgggggc gtcgcgagtc
     3241 gcgccccaat ggccccctgg ccgcccgcgc gggacctacg gccgggtctc gcggtacccg
     3301 tcgaggttcg ggtcccggtg cgagagcgcg gcccgcaggg cggggtcctc cagcgcccgc
     3361 agaccccgca ccgccaccga cgtcaggtcg tcccgcgagg gcagcgcgcc gagcagccgc
     3421 cgccccgccg gggaggccca gcgcgtggtc ggcacctcga agcgggctat ggccagacag
     3481 ctcaccgtga ggaagaacgg cagcgcgaac cacaccgcta ccggcagctc cccctcgcgc
     3541 ccctcggccg gaagcagcgt cgcgcacgcg ccgaggacga ccacggcgac cgcggccgcc
     3601 cgcacctgcc gcgccgcgcc agcgatcccc gaccacatgc cgtccggcac cgcgagaccc
     3661 gccgcgacca ggcggtccgc gagcgcccgc accccgtccc cggccgccgc ggccgtgcgc
     3721 accggcgcga tccgcgactg cccggccgga ccgatcgcgc cgagcaccga ccgctccagg
     3781 tcgtcccccg ccaccggatc caccaccgtc gcccaccccg tgtgcgcgag cagcaggcgc
     3841 cgcctccgcg ccatggagag gagcgccacg tcgacgaccc gcccgggccc gcccgacagg
     3901 aacgccgcct cgtacagcgt cagatgccgg ccctcgtgcg ccccgcgcgc ctcactggcg
     3961 gcggcgcgca ccgcggccac gcagagccgg ccgcaggaca gtgcggcgag agcacaggcg
     4021 agaagcagca gcgggaccca gaacatgccg gttttctatg tgaaggaggt gtgacgccgc
     4081 taccggtatt ccacgatgtg gacacctctt cttcaccggc tgccccgccg tcccgccccg
     4141 cctcagtcgc gcagtcccgg cgcgggccgc gagaccgcgg gcggcagcga gtacgtggga
     4201 ttcggtgccg ccggtgccgc cgggggcggg gagtcctggg ggcccggggg cgcgggggag
     4261 cgggccgggg gcggggtggt ggccgtggcg gcgtcgcggg ccaggccgtc gaagtcgacc
     4321 aggcccgtcc cctccaggac cttgatgtgg tcgaggaccg tggtgttcgc gtcgtcggcg
     4381 agcgcccgca cctgggagtt gcgggtggtg gcgcggacct ccgcgacgag gctgaagacc
     4441 ttgccgtgcg cgcgccgcag gatgttcgcg aacttcacgt cgtacgccgt gccgcgctcc
     4501 gcgctcagct ccgcgagcca gcggcgctgc tgggcgctgg gctggctcgg cagttcgagc
     4561 cgcagcgccg ccgccacctc gcgcacccgg gcgtccagga acgcgtgccc ctcgaccagg
     4621 tgcttgcccg cgacgtgcac ggcccgggtg gtgccgcgct ccccggcttg ctggcccgcg
     4681 ggcagctccc acaggccggc gagccgcacc ttggtgacga agtcccggtc gagcgcggac
     4741 agcggtccgt agtccgtcga cacggtctgc gaggtgagcg cgtcgaggcc ggtgcccgag
     4801 cggtcctcgt acgaccacac gggatagacc agcgcggcca gcgtgaccac gagcccggtg
     4861 agaacgagac cgctgccgct gatgattcgg gaacgcatga cgcctcctgt cgcgccaccg
     4921 cacgctagtg cgcggcgtgg gggaggcgtc ccgcataccg gacggagtac gccaacggct
     4981 gtacggaaag cggtaggtgg ttacgtcgcc ggggcggggt cggcgtccac gcccgcgtgg
     5041 ccgggggcgc gccgccgcgc cctgcgcagt gcgagccggg ccgtccgcgt ccgcagccag
     5101 cgggtgaggg ggtgtccatc gagcggcttc gggcccgagc gctccagcca ccaggccgtc
     5161 agctcgccgc gcgccgccgc gtcctcgggc cgcccggcga gcagcaggtg ctcggcgaag
     5221 tcaagggcgt cctggcggta gccgcccgtc atggggcggg tgcgggcgta gccgaggaag
     5281 tccgcgcggt acgactcgcc gatgatccac ggcagttcgg gggcgacctt cgccaccacg
     5341 tccgcccgct tggcgcccag cgcgcggctc tgcacccgga gccgtgcccc gtcgaagccc
     5401 tccggcgcgg gggtgcccgc gacgagcgcg gagaggaagg cggcctgggc gagggcgacg
     5461 cgctggcggg cctcgggggt ggcggcgggg ccgggcacgg ggccgtcggc cgggtccggc
     5521 gcggggtcgg ggtcgggcgc gggggccgcc gctgcggacc ctgccgttgc cgtagccgta
     5581 gccgtagccg ttgccgtcgc caccgtctcc cggatcgccg tcaactcccg ttccagctcg
     5641 ccctcctcgg ggaagttctc gtcccgctcc aggagcacgc cgggcggccg ggtgcgcgag
     5701 gcgaggtcgg cgaggatgtc gaggacgggc tgcggcacgg cgtgcgcgtg gctgtcgtgc
     5761 cacacgccgt cccgctcgaa gccgcccgcc acatggacgt acgcgatggc ctccaccggc
     5821 agctcgtcca gggcgcggga cgggtcctcg ccccggttga cgtggttggt gtgcaggttg
     5881 gcgacgtcga tgagtagccg gacaccggtc cgctccacca gctcgtacag gaactggccc
     5941 tccgtcatct cctcgccggg ccaggagatg agggcggcga tgttctcgac ggcgagcggc
     6001 acgggcagcg cgtcctgggc gatgcggacg ttctcgcaca gcacggcgag cgcgtcccgg
     6061 gtgcgcggga cgggcagcag gtggcccgct tcgaggtgcg gtgaggcggt gagggcgcca
     6121 ccggcccgta cgaacgcgat gtgctcggtg acgagcggcg agccgagtgc ctccgcgcgc
     6181 tccgcgaggg cggtgagccg ggcctcgtcc gggcgctccg cgccgccgag gccgagcgag
     6241 acgccgtgcg gcacgaccgt cacgccgcgc tcgcgcagcc gcagcagcga gtcgggcagg
     6301 tggcccgggc acacgttctc ggcgacggcc tcgacccagt cgacgccggg catgcgctcg
     6361 acggcgtcgg cgatctccgg acgccatccg atgccggtcc ccagctgagc catggttcct
     6421 cgtgcggtgc ttccccctgc gatggttcct tgtgctgtcg tcccccgtgc ggtcatcgtc
     6481 gttccccctc cttgccgctg gtcctccccg gtcgttcacg tagccgtagt catgaccgcg
     6541 ccagaccggg gtgaaccttc tgatcagggg tttcagagct acatttgagg ttcgggccgg
     6601 tcggtgttca ccgtgcccgg agcgccggga gagggccgtg aggtgccgga gacgtcgccg
     6661 gtgggaccgg cgggttcggg ctgcggggga gtgttgccgt cgggcggcgg gggccccgtc
     6721 gggctcgccg tggacttgcc cgcggtgtcg ttcgcgatgg cgtcgaagtc gacgtagccg
     6781 gtgccttcga gcacggtgat gtggtccagg acggtctggt tggcgtcgga cgcgagttgg
     6841 cgcacgaggg agttgcgagt ggtgtcccgc acctgggcga tgaggctgaa gaccttgccg
     6901 tgtgcgacgc gcagcaggtt ggcgaacttg cgttggtagt cctcgccggt cgcgtcggtc
     6961 aactcccgca gccagccctg ctgttgggtg gtgggctggt tgggcagctc gacgccgagc
     7021 tgggcggcga tgccgcgcac ccgctcgtcg aggtcggtgt ggccgacgat cagatggtcg
     7081 cctgcctcct tgatggcctt gctgggcgcg cgctccacgg cctgctggcc cgcgggcagc
     7141 tcccagagtc cggcgaggcg caccttcacg atgaagtccc ggtcggtcgc ggacagcggg
     7201 ccccaacggg tcgacacgct cccggcgttg aggttcgcct cgcccgtgcc cgaacggtcg
     7261 gcgtaggacc acaccgggaa ggcaagggcg cccacggtga cgacgagcgc cgcgatgatc
     7321 agggccgtgc cgttgatacg ccccatgtgc ctgatgcgct gcaaagtgcc tcccgagccg
     7381 catcccggcc gggggccggg ccacttggtg gtacgggaag gtacgggagg ggcggggccg
     7441 gtgttcagcg acgtgaaggt tctgtgacgg gggtcacgtt ctgggggcgc gtgggcgggt
     7501 ggcgcgcggc ctcggtgttg tcggtggcgt ccactagggt ccggaaggac agaggccaca
     7561 cggggaattg gggaggggcc atggcgcctg cggagccgat cgacttgatc cgcctggagg
     7621 gcgaggacaa cagcgtcgtc gtcaggatca ccggaaagcg tcccgcgccg gggcgtcccg
     7681 gaatcgacga actcgtcggc gagatcctcg tcgacaccgc cttcgtccgg gggacgctcg
     7741 ccacgtcggt gtccccggag gacctcaccg agtggcgcga gaccctcgac gccctcgacg
     7801 gcggcgacga cagcacctgg cgcgagggcg gccgcgcccc cgaactcctc gtcgagctgg
     7861 acccggacgg cgagcgcgcc cacgtcacgg tcgccgacca cgcgatgtcc ctgaccacgg
     7921 tcacggcgac cgtcacgctc acggacgagt ggttcgacga ggcgtacgac cggttggacg
     7981 cgacgttgcg ggcttggccg gtggaggggg cgttgcaggg gtgagggcag gtgcccgtgt
     8041 cacggctcgg ccacgatgcg tgcacccgcc gacgtcggcg ttcacatcac ctccacaatt
     8101 ggatgtctac gtaccgtcct tggggggaca gaacatgaac gccagcacga tcgacaccga
     8161 cgccgaacgc ggcggcaccg ggaccgccgc cgtccacacc ggcaccgcga ccagaagcac
     8221 cctgttcgcc gcggccgcgg tgctcacgct cggcgtggcc ctgaccgcct gcggcgacgg
     8281 cgacaagccg cgccccgccg tgacggtcac caagaccgtc acggcggggg gnnnnnnnnn
     8341 nggggccgcc gagtccaagg acgacaccct ggggctcacc ggcaccgcgg tctacgagaa
     8401 caagaacgag gtgtccctgt cgtccttctc gcggggcgtc tcgggcccgt acgcctcacc
     8461 ggagcgcacc ccgtacgtca agttcacgct gaagctcaag aacggcacgg acaaggtcat
     8521 cgacatgagc gcgctgtcgg tcctgtgcca gtacgggcac gaggccaagg acggcgagca
     8581 gatcttcgac agcgagaacg gcctggacgg cccgccccag acccatctgc gccccggccg
     8641 ctccatcacg gcgacgctgg gctgtgaact gcccacgtcg cagaagcacc tgcagatcga
     8701 ggtcacgccg gacttcgaga cggaggcggc gatcttctcg gggaaggtga agtaggggcc
     8761 ggggcggccg ccggaggggc ggagcgccgg gcggggctca ggggcgtcgc agggccgggt
     8821 ggtccgccac caccgtgcag gagccggggg cgatctccgt gaagcccgcg tcgcggacca
     8881 cggggaggcc gctcgtggtc agttcgggcc agcgggacgc gggggccgtg cggacggaca
     8941 gggggaagcc cgcgtcgcgc caggccgtgc gggccggggc ggagaggtcc caccaggcca
     9001 gctgggcgcc gtggcccgcc tgagccatcg ccttgcccgc cgacatgccg acgtcggggt
     9061 tcaaccagag gacgggggtg gacgggtcgg cgtcccgcgg cggctccggg tcgtccaggt
     9121 ccgtgccgga gacctggagg cgggccaggt ccttgggcca gccgtcgagc ggcaccggcg
     9181 gatacacccg cacctcggcc gacttgcccg tcaccgtgat cccgggcagc gcctccgccc
     9241 gccgccactc cgcgccgcgc gccctgcgca ccaccttgcg gatgcgggcg tcctgccagt
     9301 cccgcatcac ctgcgcccac tgcccctcgc ccagcgcccg ctcgtcgctc aggatcgtca
     9361 ggaccgcgcg ggccgccgtc tccagcgcgt ccgtacgggc cgggggcgcg gcccgctcga
     9421 tccgggccac caggggcagc acgaactgcg gggcctcgtc gcgcggcgtg cgctcgacgc
     9481 ggaaggggct gctcggagcg gagcccccgg cggccggggt gccctgggcg taccgggcgg
     9541 cctgggaggg ctgtgccgcc tcgggagccc gcgtggtcgg ggagtggtcc gggcggggcg
     9601 cgttgctggt cacccgtcca gtctgccagg gccgtgatcg ccgccccgct cagcccgagc
     9661 aagccgtccg ctgggcctcc tgccactcgc agaccgggca cagggtggcg ccccggtggg
     9721 actccgggta ctccgtgggc ttcctgcaca gcacgcactc cgcgaacggc gggccctccg
     9781 ccgggcgggg gccggtcgca ggggccgggg cgcagtactc gtcgtcgtcc gccatggtga
     9841 cgagcctagg tgctgcccgg ctgtgcgggc ggccggggtg acaggggccg ccgggcagcc
     9901 gcagggccgc cggacggcag ccgggcccac cggggctcgg ccgcgcacgc ggtgtcggac
     9961 ggcgctgcac gccggcgccg gtgatccggg aagagcgggc tcaggccgcc ctgccctcct
    10021 tcggtgcgcg cgcggccccg atctgctccg agacccggac gaagcggaac ccgcgctcgc
    10081 gcagcttcgg cacgatcgtg cgcagggcgc gctccgtcgc gggcgcggcg ctgcgggtgc
    10141 agtgcaggac gacgaccgag ccgggccgca ccccgtcgag cacctgccgc gccaccgcgc
    10201 gggggtccgt ggcgaacgcg tcgccgccca ccacgtccca ctgcaccgcg gtcaccccgg
    10261 ccggggcgag cgcgcgcagc gcccgctggt cgtaacagcc gcccgggaag cggaagtacg
    10321 gcaccgggtg ctcgacgccc gccctgcgga acgcggcgaa ggcgcgctcc acgtcggcgc
    10381 gcatgcggtg cggggcgacg gtgggcaggc cgtagcagtc gcgggtgaag gagtagtggc
    10441 tgtacgagtg gttggcgacc tcgaagaggg ggtcccggcc gatggccctg gcctgcgccg
    10501 ggtactcctc cgcccaccgg cccgtcatga agaacgtcgc cgggacgtca aggcggcgca
    10561 gcgtgtcgac gagcgccggg ttgtcgaagc gttcgcccgc ccgggcgcgg gggccctgac
    10621 cggccgtcat gtcggcgtcg aaggtgaggg cgaccgtggg cgcgccctgc ttggcgcggg
    10681 gagcgttctt gaagaccggg gtgaggccct gggggcccgg ggcgagggtg ggcggggcgg
    10741 ccttctgggg gctgtggtgg ggagcggggc tgtgggggcg ggtgggggtg gagggtgagg
    10801 cgcaggcgct gagggcggtc agggccgccg cggcgagtgc ggccagggag gcgcgggcgg
    10861 cccgctgccg tgcacgagtg atcatgcggt gaagataact gtgcaaatag gattaatcgg
    10921 gtaggcgagg ctcgcccgag ggggtgccgg gccggagcgc gggggagccg ccgaagcccg
    10981 cggggtgttg aagttcgcgg ggcgccgaag ctcgcgggag ccgtcgaagc aagcgcgacg
    11041 ccgaagcacg cggaccccga agcccacgga aaagccgaag cccacggaaa agccgaagcc
    11101 cgccgtggac cgcgcgggag acaatgcgcg cccggcccat gatcgtacga aaggacgtgc
    11161 cccatgcccg cctccctcta caacgtcgcc ttcggctgcg cggacgcgta cggactcgcg
    11221 cggttctgga gcgaggtggt ggggcatccg ctggacgagg aggaccggcc gggtgacccc
    11281 gtcgccgtga tcgcgctgcc cacgggcctg cacctgtact tcgagaacgt ccccgagccc
    11341 aagaacggca agaaccgtgt gcacgtgtgc ctccggccgg acggcccgcg cgacgaggag
    11401 gtcgagcggc tcc
//
