LOCUS       NZ_RHGC01000007        10405 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig007, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000007
VERSION     NZ_RHGC01000007.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 709612)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 709612)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 604677
            Orig. end                         :: 615082
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000007.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10405
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ectoine"
                     /region_number="1"
                     /rules="ectoine_synt"
                     /tool="antismash"
     cand_cluster    1..10405
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="ectoine_synt"
                     /kind="single"
                     /product="ectoine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10405
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5405](-)"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5405)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="ectoine_synt"
                     /neighbourhood="5000"
                     /product="ectoine"
                     /protocluster_number="1"
     gene            119..895
                     /locus_tag="EJ355_RS30070"
     CDS             119..895
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643606.1"
                     /locus_tag="EJ355_RS30070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DsbA family oxidoreductase"
                     /protein_id="WP_125264174.1"
                     /transl_table=11
                     /translation="MRVEIWSDIACPWCYVGKARFEKALAAFPHQDAVEVIHRSFELDP
                     NRPKGDTAAVIPMLAQKYGMTEDQAKDAERRLGDNAAAEGLAYRTEGRDHGNTFDMHRL
                     LHFAKEKGGQDAQDRLIGAFYRANFAEERSVFDDDERLIALAADAGLDADAARAVLADP
                     DAYAEAVRADEREAAELGANGVPFFVLDRKFGVSGAQPAEVFTQALEQAWGARSPLTVL
                     AEGAADTTDGDACGPDGCAVPGAGPEPDDIPPGRRP"
     gene            969..2117
                     /locus_tag="EJ355_RS30075"
     CDS             969..2117
                     /NRPS_PKS="Domain: Aminotran_5 (37-375). E-value: 1.7e-20.
                     Score: 65.2. Matches aSDomain:
                     nrpspksdomains_EJ355_RS30075_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006143405.1"
                     /locus_tag="EJ355_RS30075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_087883573.1"
                     /sec_met_domain="Aminotran_5 (E-value: 5.1e-17, bitscore:
                     57.1, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METSGQGPVQTVQTASSPATTPAAFEKLVRSEFTPRTTYLNSAST
                     GLLPGRAVRAMHEATLSVAEGRPADMFADVEAARAAFARLVGVAPSRVAAGASVAVYSG
                     LVAASLPAGAEVLTAEGDFSSTVNPFHMRADLKVRTVPLERIAESVRPGTALVAVSAAQ
                     SADGRIADLPALRAATRAHGARLYLDASQATGWLDLVEHIADVDFLSSVAFKWLTCPRG
                     VAFFVVPDGPEDPDAPGAFGGVLALLAGWVAGERPWDSCYGPVTELARSARRFDESPSL
                     FAYAGARHSLAVIEELGVAAIRAHDLALADRFRTGLAARGHEPVAAPGSPIVSVPGLGV
                     RQAELSAAGIEVSDRAGQLRAAFHLYNTEADVDRLLEALGDS"
     aSDomain        1080..2093
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS30075_Aminotran_5.1"
                     /evalue="1.70E-20"
                     /label="EJ355_RS30075_Aminotran_5.1"
                     /locus_tag="EJ355_RS30075"
                     /protein_end="375"
                     /protein_start="37"
                     /score="65.2"
                     /tool="antismash"
                     /translation="TYLNSASTGLLPGRAVRAMHEATLSVAEGRPADMFADVEAARAAF
                     ARLVGVAPSRVAAGASVAVYSGLVAASLPAGAEVLTAEGDFSSTVNPFHMRADLKVRTV
                     PLERIAESVRPGTALVAVSAAQSADGRIADLPALRAATRAHGARLYLDASQATGWLDLV
                     EHIADVDFLSSVAFKWLTCPRGVAFFVVPDGPEDPDAPGAFGGVLALLAGWVAGERPWD
                     SCYGPVTELARSARRFDESPSLFAYAGARHSLAVIEELGVAAIRAHDLALADRFRTGLA
                     ARGHEPVAAPGSPIVSVPGLGVRQAELSAAGIEVSDRAGQLRAAFHLYNTEADVDRL"
     gene            complement(2182..2724)
                     /locus_tag="EJ355_RS30080"
     CDS             complement(2182..2724)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1284:
                     transcriptional regulator, MarR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643608.1"
                     /locus_tag="EJ355_RS30080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_030358879.1"
                     /transl_table=11
                     /translation="MKAETGTAGAAQADPACSERLPLAAQDGPVSMTISRVARLHRIAA
                     GKVLKGLGLYPGQEFVMMHLWDAGPVRQSDLIKAVDLDPSTVTKMLQRLEQAGHVRRRP
                     DPDDRRAVLVEATDASCGLLTEVRRSWGDLEDHTLAGLDPAERAELARLLGRVETNLCV
                     ETADCPEEAARRAALRR"
     gene            2890..3960
                     /locus_tag="EJ355_RS30085"
     CDS             2890..3960
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016643609.1"
                     /locus_tag="EJ355_RS30085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alkene reductase"
                     /protein_id="WP_030358880.1"
                     /transl_table=11
                     /translation="MTTAFDPIDLHGVSLANRIALAPMTRSRAGAGGVPTDLVVEYYAQ
                     RASAGLVITEGVQPSLVGQGYPDTPGLHSAEQVEGWRKVTDAVHAKGGRIFAQLMHAGR
                     IGHPSLLPDGLINVGPSPIAAAGQVYTHEGPKDFITPRELSGDEVRATIGEFVEAARNA
                     IDAGFDGVELHGANGYLIHQFLAPGSNQRDDEWGGSPEKRIRFAVEVSRAVAAEIGAAR
                     TAIRLSPGNELNGIHEPDPDEAYIALAKELGALNLAYVHVMEVGPIRDLVQRVRKEFGG
                     VFILNPSTEEPTGPDDLGLIEDGTADIVSFGALFLANPDLPARLKAGGPYNTPDKATFF
                     GGDATGYTDYPALPTA"
     gene            complement(4036..4935)
                     /gene="thpD"
                     /locus_tag="EJ355_RS30090"
     CDS             complement(4036..4935)
                     /EC_number="1.14.11.55"
                     /codon_start=1
                     /gene="thpD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014671935.1"
                     /locus_tag="EJ355_RS30090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine hydroxylase"
                     /protein_id="WP_030358881.1"
                     /sec_met_domain="PhyH (E-value: 2.6e-38, bitscore: 127.6,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPGRTADLYPTRGAEEVLIERKDPVVWSTPGTPGPFTGEDLA
                     GFERDGFRAVEQLLTPAEVTEYHAELERLVSDPVMRADERSIVEPRSQEVRSIFEVHRI
                     SEVFARLAADPRVVGRARQILGSDVYVHQSRINVKPGFGASGFYWHSDFETWHAEDGLA
                     NMRTVSVSIALTKNHDTNGGLMIMPGSHRTFLGCAGETPRDNYKKSLQMQDAGTPSDEA
                     LTKLAGEYGIRLFTGEAGSATWFDCNAMHGSGDNITPYPRSNVFLVFNSVENTAVEPFA
                     APVRRPEYIGARDFTPVK"
     gene            complement(5001..5405)
                     /locus_tag="EJ355_RS30095"
     CDS             complement(5001..5405)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ectoine: ectoine_synt"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009337952.1"
                     /locus_tag="EJ355_RS30095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ectoine synthase"
                     /protein_id="WP_087883571.1"
                     /sec_met_domain="ectoine_synt (E-value: 4.9e-54, bitscore:
                     176.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVRSFKDIEGTDRHVKAASGTWESKRIVLAKERVGFSLHETVLY
                     AGTETSMWYANHIEAVVCTEGEAELTNDETGEKFTITPGTMYLLDGHEKHTMRVKKDFR
                     CLCVFNPPVTGREDHDENGVYPLLTEPETV"
     gene            complement(5445..6716)
                     /gene="ectB"
                     /locus_tag="EJ355_RS30100"
     CDS             complement(5445..6716)
                     /EC_number="2.6.1.76"
                     /GO_function="GO:0045303 - diaminobutyrate-2-oxoglutarate
                     transaminase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: Aminotran_3 (28-366). E-value: 2.3e-73.
                     Score: 239.1. Matches aSDomain:
                     nrpspksdomains_EJ355_RS30100_Aminotran_3.1"
                     /codon_start=1
                     /gene="ectB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007448159.1"
                     /locus_tag="EJ355_RS30100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate--2-oxoglutarate transaminase"
                     /protein_id="WP_030358883.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.3e-78, bitscore:
                     259.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTITQPDLSVFETLESEVRSYCRGWPTVFDRAQGSRMFDEDGHEY
                     LDFFAGAGSLNYGHNNPVLKRALIDYIERDGVTHGLDMSTTAKRAFLETFQNVILRPRD
                     LPYKVMFPGPTGTNAVESALKLARKVKGRESIVSFTNAFHGMSLGSLAVTGNAFKRAGA
                     GIPLVHGTPMPFDNYLDGRTPDFIWFERLLEDSGSGLNQPAAVIVETVQGEGGINVARA
                     EWLRQLADVCKRWDMLLIVDDIQMGCGRTGPFFSFEEAGIVPDIVTVSKSISGYGLPMS
                     LCLFKPELDVWEPGEHNGTFRGNNPAFVTAAAALETYWADGSAMEKQTQARGEQIEQAL
                     VAIADENGDAIVEYRGRGLVWGIEFRDKPRAGAIAKRAFELGLLIETSGPESEVVKLLP
                     ALTITAEELDEGLRTLARAVRETA"
     aSDomain        complement(5619..6632)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS30100_Aminotran_3.1"
                     /evalue="2.30E-73"
                     /label="EJ355_RS30100_Aminotran_3.1"
                     /locus_tag="EJ355_RS30100"
                     /protein_end="366"
                     /protein_start="28"
                     /score="239.1"
                     /tool="antismash"
                     /translation="FDRAQGSRMFDEDGHEYLDFFAGAGSLNYGHNNPVLKRALIDYIE
                     RDGVTHGLDMSTTAKRAFLETFQNVILRPRDLPYKVMFPGPTGTNAVESALKLARKVKG
                     RESIVSFTNAFHGMSLGSLAVTGNAFKRAGAGIPLVHGTPMPFDNYLDGRTPDFIWFER
                     LLEDSGSGLNQPAAVIVETVQGEGGINVARAEWLRQLADVCKRWDMLLIVDDIQMGCGR
                     TGPFFSFEEAGIVPDIVTVSKSISGYGLPMSLCLFKPELDVWEPGEHNGTFRGNNPAFV
                     TAAAALETYWADGSAMEKQTQARGEQIEQALVAIADENGDAIVEYRGRGLVWGIEFR"
     gene            complement(6827..7384)
                     /gene="ectA"
                     /locus_tag="EJ355_RS30105"
     CDS             complement(6827..7384)
                     /EC_number="2.3.1.178"
                     /GO_function="GO:0033816 - diaminobutyrate
                     acetyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0019491 - ectoine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ectA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010987798.1"
                     /locus_tag="EJ355_RS30105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="diaminobutyrate acetyltransferase"
                     /protein_id="WP_078619547.1"
                     /transl_table=11
                     /translation="MTAAQADLPTDLQAKFREMPEGLRLDSPDVADGAAIWRIARDSKV
                     LDLNSSYSYLLWCRDFAATSVVARDAGGEPVGFMTGYLRPDKPRTLVVWQVAVDHAQRG
                     RGLAGALLDGLAAKVAARPGFDALETTISPGNTASERLFTSFAERHGARVERTVLFDAA
                     LFPGDDGGHEPEVLYDIAPLFR"
     misc_feature    complement(7393..7407)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.38"
                     /tool="antismash"
     misc_feature    complement(7445..7460)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 18.61"
                     /tool="antismash"
     misc_feature    7518..7531
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.72"
                     /tool="antismash"
     misc_feature    complement(7541..7556)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: weak, score: 16.03"
                     /tool="antismash"
     gene            complement(7794..8894)
                     /locus_tag="EJ355_RS30110"
     CDS             complement(7794..8894)
                     /NRPS_PKS="Domain: Aminotran_5 (52-295). E-value: 9.8e-27.
                     Score: 85.7. Matches aSDomain:
                     nrpspksdomains_EJ355_RS30110_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139: aminotransferase class V"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644018.1"
                     /locus_tag="EJ355_RS30110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aminotransferase class V-fold PLP-dependent
                     enzyme"
                     /protein_id="WP_030358885.1"
                     /sec_met_domain="Aminotran_5 (E-value: 1.9e-21, bitscore:
                     71.6, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHPFLDLAPLGAAHFAAIEDRVARLLDTEQDVVIMQGEALLPLE
                     GCIRGAARPGTKALNVITGPYGQTFGNWLRDCGASVVDLAVPFHTAVTAAQVEAAFAEH
                     PDIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVAAEPLLPDAWGVDLCV
                     IGAQKAMGGPAGVSAVSVSERAWQRMAANPEAPRRSYLSLLDWKERWIDGGRKALLHAP
                     AQLEMLALEACVERIEAEGLAALTVRHATAATATRAGALALGGGLEPYVYEAADAAPVA
                     TTLRAPRGVDASDLVARALAADPVLPLVAGGGALAKEMIRVNHYGPDATRGVVHASLAA
                     LGAAMGEAGLGVDLEAARRAVTEIWA"
     aSDomain        complement(8010..8738)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS30110_Aminotran_5.1"
                     /evalue="9.80E-27"
                     /label="EJ355_RS30110_Aminotran_5.1"
                     /locus_tag="EJ355_RS30110"
                     /protein_end="295"
                     /protein_start="52"
                     /score="85.7"
                     /tool="antismash"
                     /translation="RPGTKALNVITGPYGQTFGNWLRDCGASVVDLAVPFHTAVTAAQV
                     EAAFAEHPDIDFVSLVHAEAATGNTNPVAEIGEVVRAHGALFMLDAVASVAAEPLLPDA
                     WGVDLCVIGAQKAMGGPAGVSAVSVSERAWQRMAANPEAPRRSYLSLLDWKERWIDGGR
                     KALLHAPAQLEMLALEACVERIEAEGLAALTVRHATAATATRAGALALGGGLEPYVYEA
                     ADAAPVATTLRAPRGVDASDL"
     gene            9039..10127
                     /locus_tag="EJ355_RS30115"
     CDS             9039..10127
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003960017.1"
                     /locus_tag="EJ355_RS30115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amidohydrolase family protein"
                     /protein_id="WP_125264175.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 9.1e-15, bitscore:
                     49.9, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERAVLHVKGRVLVGPEDVRDELWVVGGRVTYRRPAAGDVLTVR
                     GWALPGLVDAHCHVGLDAHGPVAPDVAEKQALTDRDAGTLLLRDAGSPSDTRWIDDRED
                     LPKIIRAGRHIARTRRYIRNYAHEIEPDDLVAYVAREARRGDGWVKLVGDWIDRDAGDL
                     TACWPRGAVEAAIAEAHRLGARVTAHCFAEDSLRDLVEAGIDCVEHATGLTEDTIPLFA
                     SRGVAIVPTLVNIATFPQLADGGEAKFPRWSAHMRRLHARRYDTVRAAYDAGVPVYAGT
                     DAGGALAHGLIAGEVAELTKAGIPAVEALSSAVWRARAWLGRPGLVEGAPADLVVYADD
                     PRADVRVLAAPSAVVVNGRVVG"
ORIGIN
        1 cacacaccgc ttcggcagcc gtacggagtg agccaggcgg cgggaatgca aacgcccggc
       61 cccgggttgc acagacgcgg aggacgtctc cgtttcgtac gacccgagga agaaccacat
      121 gcgcgtcgag atctggagcg acatcgcctg cccctggtgc tacgtgggca aggcccgctt
      181 cgagaaggcc ctggcggcct tcccgcacca ggacgccgta gaggtgatcc accgctcctt
      241 cgagctggac ccgaaccgcc cgaagggcga cacggccgcc gtgatcccga tgctggcgca
      301 gaagtacggc atgaccgagg accaggcgaa ggacgccgag cgccgcctcg gcgacaacgc
      361 ggcggccgag ggcctcgcgt accgcaccga gggccgcgac cacggcaaca ccttcgacat
      421 gcaccgcctc ctccacttcg cgaaggagaa gggcggccag gacgcccagg accgcctcat
      481 cggcgcgttc taccgcgcca acttcgccga ggagcgctcg gtcttcgacg acgacgagcg
      541 cctgatcgcc ctcgcggccg acgcgggcct ggacgcggac gcggcacgcg cggtcctcgc
      601 cgaccccgac gcgtacgccg aagccgtccg cgcggacgag cgcgaggcgg ccgagctcgg
      661 cgcgaacggc gtgccgttct tcgtcctcga ccggaagttc ggcgtctccg gcgcccagcc
      721 cgcggaggtc ttcacgcagg ccctggagca ggcgtggggc gcgcgttcgc cgctgacggt
      781 gctggccgag ggtgccgctg acaccaccga cggcgatgcc tgcggtcccg acggctgcgc
      841 ggtgccgggc gccggacccg agccggacga catcccccct ggtcggaggc catgagtaag
      901 cgtcgctaag cggtacgggt caggcatccg caatggaccg ggcccggccg aggcggcaca
      961 gtgaccccat ggagacttcc ggccagggcc ccgtccagac cgtccagacc gcttcgagtc
     1021 ccgccacgac accggcggcc ttcgagaagc tcgtacgctc cgagttcacc ccccgcacca
     1081 cctacctgaa cagcgcgagc accggcctcc tgccgggccg cgccgtccgg gcgatgcacg
     1141 aggcgaccct ttccgtggcg gagggccgcc ccgccgacat gttcgcggac gtggaggccg
     1201 cccgcgccgc cttcgcgcgc ctggtcgggg tggcgccgag ccgggtcgcg gcgggcgcgt
     1261 ccgtcgccgt gtacagcggc ctggtcgccg cctcgctgcc cgcgggcgcc gaagtcctca
     1321 ccgccgaggg cgacttcagc tcgacggtga accccttcca catgcgcgcc gacctcaagg
     1381 tccgcaccgt cccgctggag cggatcgcgg agtccgtgcg cccgggcacc gccctggtcg
     1441 cggtctcggc ggcgcagtcg gcggacggcc ggatcgccga cctgcccgcg ctgcgcgccg
     1501 cgacccgcgc gcacggcgcc cgcctctacc tggacgcctc gcaggcgacg ggctggctcg
     1561 acctcgtcga gcacatcgcc gacgtggact tcttgtcgtc ggtggccttc aagtggctca
     1621 cgtgcccgcg gggcgtggcg ttcttcgtgg tccccgacgg ccccgaggac cccgacgccc
     1681 ccggggcctt cggcggggtg ctcgcgctgc tcgcgggctg ggtcgcgggc gagcgcccct
     1741 gggacagctg ctacggcccg gtcaccgagc tcgcccgctc cgcgcggcgg ttcgacgaga
     1801 gcccgagcct gttcgcgtac gcgggcgcgc ggcactccct cgccgtgatc gaggagctgg
     1861 gcgtggccgc gatccgcgcc cacgacctgg cgctcgcgga ccgcttccgg accggcctcg
     1921 cggcgcgcgg ccacgagccg gtggccgcgc cgggctcgcc catcgtttcg gtgcccggac
     1981 tcggcgtccg ccaggccgag ttgagcgccg cgggcatcga ggtgtcggac cgcgcggggc
     2041 agttgcgggc ggccttccac ctgtacaaca cggaggccga cgtggaccgg ctcctggagg
     2101 ctctgggcga cagctgagga gccggagcgg gccgcacggt cggggcgggg ccgaggccgc
     2161 gccgccccgg aaagccccgc cctacctgcg cagcgccgcc cgccgcgccg cctcttccgg
     2221 gcagtccgcc gtctccacgc agaggttggt ctcgacccgg ccgagcagcc gggccagctc
     2281 cgcccgctcg gccgggtcga gcccggcgag ggtgtggtcc tccaagtcgc cccaggagcg
     2341 ccgcacttcg gtgagcaggc cgcagctggc gtcggtcgcc tcgacgagca cggcccggcg
     2401 gtcgtccggg tcggggcgcc gccgtacgtg cccggcctgc tccaggcgct ggagcatctt
     2461 ggtgaccgtc gacgggtcga ggtcgacggc cttgatgagg tcggactggc gcaccgggcc
     2521 cgcgtcccac aggtgcatca tcacgaattc ctggccgggg tagaggccga ggcccttcag
     2581 gaccttgccc gccgcgatcc ggtgcagccg ggccacccgg ctgatcgtca tgctgaccgg
     2641 cccgtcctgg gcggccagag gcagccgctc gctacacgcg gggtcggcct gcgcggcccc
     2701 cgccgtccct gtctcggcct tcatcgcagc tcctgccctt cgccggcccg gccctgtccg
     2761 ccgtcgccgt cctccaccag tgtcgtcctg gttcccctcc gagattaact tggtcggcca
     2821 aggaatgcgc tacagtggct ctcggttgaa ttacttggcc gaccaatctt cgtacgccct
     2881 ggagctgtga tgaccaccgc attcgacccg atcgacctgc acggcgtgtc cctcgcgaac
     2941 cgcatcgcac tggcgcccat gacccgcagc cgggcgggcg cgggcggcgt ccccaccgac
     3001 ctcgtcgtcg agtactacgc ccagcgcgcg agcgcgggcc tcgtgatcac cgaaggcgtg
     3061 cagccctccc tggtgggcca gggctacccg gacaccccgg gcctgcacag cgccgagcag
     3121 gtcgagggct ggcgcaaggt caccgacgcc gtgcacgcca agggcggccg gatcttcgcc
     3181 cagctcatgc acgcgggccg catcggccac ccctcgctgc tcccggacgg cctgatcaac
     3241 gtcggcccct cgccgatcgc cgcagccggg caggtctaca cgcacgaggg accgaaggac
     3301 ttcatcacgc cccgcgagct gtccggggac gaggtgcgcg ccaccatcgg cgagttcgtc
     3361 gaggccgccc gcaacgcgat cgacgcgggc ttcgacggcg tcgagctgca cggcgccaac
     3421 ggctatctga tccaccagtt cctcgcgccg ggctccaacc agcgcgacga cgagtggggc
     3481 ggctccccgg agaagcgcat ccgcttcgcc gtcgaggtgt cccgcgccgt cgcggccgag
     3541 atcggcgccg cgcgcacggc catccgcctg tcgcccggca acgagctcaa cggcatccac
     3601 gagcccgacc cggacgaggc ctacatcgcc ctcgcgaagg agctcggcgc cctgaacctg
     3661 gcgtacgtgc acgtcatgga ggtcggcccg atccgcgacc tggtccagcg ggtgcgcaag
     3721 gagttcgggg gcgtgttcat cctgaacccc tcgaccgagg agcccacggg acccgacgac
     3781 ctgggcctga tcgaggacgg caccgccgac atcgtgtcct tcggcgccct gttcctcgcc
     3841 aacccggacc tgcccgcgcg cctgaaggcg ggcggcccct acaacacgcc cgacaaggcg
     3901 acgttcttcg gcggcgacgc cacgggctac acggactacc cggcgctgcc gacggcgtag
     3961 ccgacccgga gcacacgggc atgagtcggc ccggcatcct gtgggatgcc gggccgactc
     4021 atgtgtgagg cacggtcact tcaccggggt gaagtcccgc gccccgatgt actcgggccg
     4081 ccgcaccggc gccgcgaacg gctcgaccgc ggtgttctcc acgctgttga agacgaggaa
     4141 gacgttcgag cgcgggtagg gcgtgatgtt gtcgccggag ccgtgcatgg cgttgcagtc
     4201 gaaccaggtc gccgagcccg cctcgccggt gaacagacgg atgccgtact ccccggcgag
     4261 cttggtcagc gcctcgtcgg acggcgtgcc cgcgtcctgc atctgcaggg acttcttgta
     4321 gttgtcccgc ggcgtctcgc ccgcgcagcc gaggaacgtc cggtgcgagc cgggcatgat
     4381 catgagcccg ccgttggtgt cgtggttctt ggtgagcgcg atcgacaccg acacggtccg
     4441 catgttcgcg aggccgtcct ccgcgtgcca ggtctcgaag tccgagtgcc agtagaagcc
     4501 cgacgccccg aaccccggct tgacgttgat ccgggactgg tggacgtaca cgtcggagcc
     4561 gaggatctgg cgggccctgc cgaccacgcg cgggtcggcg gcgaggcggg cgaagacctc
     4621 gctgatccgg tgcacctcga agatggaccg gacctcctgg gagcgcggct cgacgatgga
     4681 gcgctcgtcc gcgcgcatca ccgggtcgct cacgagccgc tccaactcgg cgtggtactc
     4741 cgtgacttcc gcgggagtga gcagctgctc gacggcccgg aagccgtcac gttcgaaccc
     4801 cgccaggtcc tcgccggtga agggccccgg cgtacccggc gtggaccaca ccacggggtc
     4861 cttgcgctcg atgaggacct cttcggcgcc tcgggtcggg tacaggtcgg cggtgcgtcc
     4921 gggtgcggtg gtcatggtgt tgcctgcctc tcctctctcg tacggccctg tgcgggattg
     4981 cccttgccgc agcgtgcggt tcagaccgtc tccggctccg tgagcagcgg gtacacgccg
     5041 ttctcgtcgt ggtcctcgcg gcccgtcacc ggcgggttga acacgcacag gcagcggaag
     5101 tccttcttga cgcgcatggt gtgcttctcg tgcccgtcga gcagatacat cgttcccggc
     5161 gtgatggtga acttctcgcc ggtctcgtcg ttggtcagct cggcctcgcc ctcggtgcag
     5221 acgacggcct cgatgtggtt ggcgtaccac atgctcgtct ccgtaccggc gtagagcacg
     5281 gtctcgtgca gcgagaagcc gacgcgctcc ttggcgagca cgatgcgctt gctctcccag
     5341 gtgcccgacg cggccttgac gtgccggtcg gtgccttcaa tgtccttgaa cgagcggacg
     5401 atcacggtga gtcgtttcct tgtctgtgcg tgcggtgtgc gtgttcaggc ggtctcgcgg
     5461 accgcgcggg cgagcgtgcg caggccctcg tcgagctcct cggccgtgat ggtgagggcc
     5521 gggagcagct tgacgacctc gctctcgggt cccgatgtct cgatgagcag gccgagctcg
     5581 aaggcgcgct tggcgatggc gcccgcgcgc ggcttgtcac ggaactcgat gccccagacc
     5641 aggccgcggc cgcggtactc cacgatggcg tcgccgttct cgtcggcgat cgcgaccagg
     5701 gcctgctcga tctgctcgcc gcgggcctgg gtctgcttct ccatggccga gccgtcggcc
     5761 cagtacgtct ccagggcggc ggccgccgtg acgaacgccg ggttgttgcc gcggaaggtg
     5821 ccgttgtgct cgcccggctc ccacacgtca agctccggct tgaacaggca gagcgacatg
     5881 ggcaggccgt agccgctgat ggacttggac accgtcacga tgtccggcac gatgcccgcc
     5941 tcctcgaagg agaagaaggg gccggtgcgg ccgcagccca tctggatgtc gtcgacgatc
     6001 agcagcatgt cccagcgctt gcagacgtcg gcgagctgcc gcagccactc ggcgcgcgcg
     6061 acattgatgc cgccctcgcc ctggaccgtc tccacgatca cggcggcggg ctggttcagg
     6121 cccgaccctg agtcctccag gaggcgctcg aaccagatga agtcgggggt ccgcccgtcc
     6181 aggtagttgt cgaacggcat cggcgtgccg tgcaccagcg ggatgcccgc gcccgcccgc
     6241 ttgaaggcgt tgccggtcac cgcgagcgag ccgagcgaca tgccgtggaa ggcgttggtg
     6301 aaggacacga tcgactcgcg gcccttgacc ttgcgggcca gcttcagcgc ggactccacc
     6361 gcgttggtgc cggtcgggcc cgggaacatg accttgtacg gcaggtcgcg cgggcgcagg
     6421 atgacgttct ggaacgtctc gaggaaggcg cgcttggcgg tcgtcgacat gtcgaggccg
     6481 tgggtgacgc cgtcccgctc gatgtagtcg atcagggcgc gtttcagcac ggggttgttg
     6541 tggccgtagt tgagcgagcc ggcccccgcg aagaagtcga ggtactcatg accgtcctcg
     6601 tcgaacatgc ggctgccctg cgcgcggtcg aagacagtgg gccaaccgcg gcagtagctg
     6661 cgcacctccg actccagggt ctcgaagacg ctcaggtcgg gctgggtgat ggtcacagcg
     6721 gatctcctgg gagatggatt gatcgtgagg gggcttgagt ggactgggat cgtgccgggg
     6781 gcatgtgacg gcgcgtcagg cctccggcgg cgcggctgcc ggccggtcag cggaacaggg
     6841 gggcgatgtc gtacaggacc tcgggctcgt gcccgccgtc gtcgccggga aacagggccg
     6901 cgtcgaacag cacggtccgc tcgacgcggg cgccgtggcg ctcggcgaac gaggtgaaca
     6961 ggcgctcgga ggcggtgttg cccggggaga tggtcgtctc cagggcgtcg aacccggggc
     7021 gggcggcgac cttcgcggcg agcccgtcga gcagcgcacc ggcgaggccg cggccacgct
     7081 gcgcgtggtc gacggccacc tgccagacca ccagggtgcg cggcttgtcg gggcggaggt
     7141 agccggtcat gaacccgacg ggctcgccgc ccgcgtccct ggccacgacg gaggtcgccg
     7201 cgaagtcgcg gcaccacagc aggtagctgt acgaggagtt caggtcgagg accttcgagt
     7261 cgcgggcgat ccgccagatc gcggcgccgt cggcgacgtc ggggctgtcg agccgcaggc
     7321 cctcgggcat ttctcggaat ttcgcttgca ggtcggtcgg tagatcggct tgtgcagcgg
     7381 tcatgcggat tgaatttacc gagcaatttc tgggattgca tcgggggaag gggttacgcg
     7441 cggcgcttcc atgtgttatc acgcaggcgc gggcgcccgc acgaaaagcc ggggttttgt
     7501 ggcggtattg cctgatttat ttccgacaaa acgggcttgc tgtggagtgc gtcacagtgg
     7561 cgtaatcccg atgagacgtg cccgaattac ggcgcttggt gctggcgaaa ccttagtgtt
     7621 tagggtctcg gaaaccgggc agaagaatac gggaagctgc actcataatg aattcatgaa
     7681 agcgcacggg gtaattgccc tggagcgctt tatcgcggtg cgtgaatcgc gattcccggc
     7741 ggtgccggac gggccgtccc ggagggaaga gcccgaccgg cgcacgccca ggcctacgcc
     7801 cagatctccg tgacggcacg ccgggccgcc tccaggtcaa cgccgagtcc cgcctcaccc
     7861 atcgccgcac cgagcgccgc aagcgacgcg tgcaccacgc cccgcgtcgc gtccgggccg
     7921 tagtggttga cccggatcat ctccttggcc agcgcgcccc cgcccgccac cagcggaagc
     7981 accgggtcgg ccgccagcgc ccgcgccacc aggtcggagg cgtccacgcc ccgcggcgcc
     8041 cgcagcgtcg tcgcgaccgg cgcggcgtcc gcggcctcgt acacgtacgg ctccagaccg
     8101 ccgccgagcg cgagggcgcc cgcgcgcgtc gccgtcgccg ccgtcgcgtg ccgcaccgtc
     8161 agcgcggcca ggccctccgc ctcgatgcgc tccacacacg cctccagggc cagcatctcc
     8221 agctgcgccg gggcgtgcag aagtgccttg cggccgccgt cgatccaccg ctccttccag
     8281 tccaggaggg agaggtacga gcggcgcggg gcctcggggt tggcggccat gcgctgccag
     8341 gcgcgctcgc tcaccgacac cgccgacaca cccgcgggac cgcccatggc cttctgggcg
     8401 ccgatcacgc acaggtccac gccccacgcg tcagggagca gcggctcggc ggccaccgac
     8461 gccaccgcgt ccagcatgaa cagcgcgccg tgcgcccgta cgacctcccc gatctccgcc
     8521 accggattgg tgttgccggt cgccgcctcc gcgtgcacca gggacacgaa gtcgatgtcc
     8581 gggtgctccg cgaaggccgc ctcgacctgc gcggccgtca cggcggtgtg gaacggcacc
     8641 gcgaggtcca cgacgctcgc gccgcagtcc cgcagccagt tcccgaaggt ctgcccgtac
     8701 ggaccggtga tcacgttcag ggccttcgtg ccgggccggg cggcgcccct gatgcagccc
     8761 tccaggggca gcagtgcctc gccctgcatg atcacgacgt cctgctcggt gtccaggagc
     8821 cgggccaccc ggtcctcgat ggcggcgaag tgcgcggcgc cgagcggcgc caggtcaagg
     8881 aaggggtggg tcacgctgct gctcgcttcg gtaacggggt ctctacggcg ggtcggtgag
     8941 gcggccgcgg ggctcggccc ccggtctctc gccgtcgagc gtacccaccg cccccgtcag
     9001 ccctgtcgcc tcccacgctg ctgtctaagc tgacgcacat gagcgaacgc gcggtgctgc
     9061 acgtgaaggg gcgggtgctc gtagggcccg aggacgtacg cgacgagctg tgggtggtcg
     9121 gcgggcgggt gacctaccgg cggcccgccg ccggggacgt gctcaccgtc cgggggtggg
     9181 cgctgcccgg cctcgtcgac gcgcactgcc acgtcggcct cgacgcccac gggcccgtcg
     9241 cgccggacgt cgccgagaag caggccctca ccgaccgcga cgcgggcacc ctgctcctgc
     9301 gcgacgcggg ctcgccctcc gacacccgct ggatcgacga ccgcgaggac ctgccgaaga
     9361 tcatccgggc cgggcggcac atcgcgcgga cccggcgcta catccgcaac tacgcccacg
     9421 agatcgagcc cgacgacctc gtcgcctacg tcgcccgtga ggcgcggcgc ggtgacgggt
     9481 gggtcaagct cgtcggtgac tggatcgacc gtgacgccgg ggacctcacc gcctgctggc
     9541 cgcgtggtgc cgtcgaggcc gccatcgccg aggcccatcg gctcggggcc cgggtcaccg
     9601 cccactgctt cgccgaggac tccctgcggg atctcgtcga ggccggcatc gactgcgtcg
     9661 agcacgccac cgggctcacc gaggacacca tccccctctt cgcctcccgc ggtgtcgcca
     9721 tcgtgcccac cctcgtcaac atcgcgacct tcccgcagct cgccgacggt ggcgaggcga
     9781 agttcccccg ctggtccgcc catatgcggc ggctccacgc ccgtcgctac gacaccgtcc
     9841 gtgccgccta cgacgccgga gtccccgtct acgccggcac cgacgccggc ggggccctcg
     9901 cccacggcct catcgccggg gaggtcgccg agctcaccaa ggccgggatt ccggccgtcg
     9961 aggcgctgtc ctccgccgtg tggcgtgcgc gggcctggct ggggcgcccc gggctcgtcg
    10021 agggcgctcc ggcggacctc gtcgtgtacg cggacgatcc ccgggccgac gtccgggtcc
    10081 tcgccgcgcc ctccgcggtg gtggtgaacg ggcgggtggt gggctgaggc ggcgccctgc
    10141 cgggggctcc ccaaccccac cccttcccga acccggggct ccgccccgga ccccgtatcg
    10201 acgctccgcg cctcgtcctc aaacgccgga cgggctggaa ggggtggggg tcccgtgcgg
    10261 gtgggacggg cccccgccga agtcggcgct gcgcgcctcg tcctcaagcg ccggacgggc
    10321 tggaaatagc gccggggtgg gctgagggcc tccctgggtg ggcggggaac gtcgccgggg
    10381 tggtcggaga cttccctggg gtggt
//
