LOCUS       NZ_RHGC01000006        22511 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig006, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000006
VERSION     NZ_RHGC01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 821110)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 821110)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 383705
            Orig. end                         :: 406216
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22511
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="6"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22511
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22511
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12511](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12511)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     gene            complement(296..1279)
                     /locus_tag="EJ355_RS25440"
     CDS             complement(296..1279)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1120: AsnC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983285.1"
                     /locus_tag="EJ355_RS25440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Lrp/AsnC family transcriptional regulator"
                     /protein_id="WP_087886479.1"
                     /transl_table=11
                     /translation="MESHTPDGADELDMKLLQALETDGRASFSKIAKVLGVSDQTVARR
                     YRRLTADGGLRVVGMRNAERLGRDHWILRLRCAPDGATTIAGALARRPDTFWVGLTSGG
                     TEVVCLTRPRTPGDREDLLLGKLPRTPSIVEIRAHQLLHSFFGGPRGWLGKLAPLTEEQ
                     RAALTPDRPRAGGGPARIAPEDEALVKALEADGRATYPQLQRATGLSESAVKRRLAALL
                     DAGGVFVDVEYSPEMLGFHTAAILWITAAPGALHSVGEALAGHFEIAFASATAGPSNLV
                     ATAVARDTAGLYGYISGRLGQLDGVQHVETAPFLRRVKQLTYRPGR"
     gene            1404..2936
                     /locus_tag="EJ355_RS25445"
     CDS             1404..2936
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016640597.1"
                     /locus_tag="EJ355_RS25445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_125263882.1"
                     /transl_table=11
                     /translation="MRTWGPLTAVCLGTFMLLLDVTIVVVALPDMARALDASLSDLQWV
                     IDGYALALAALLLGVGAAADVLGRRRIQVAGTVVFALASLGCGLASNAEILVAARAVQG
                     LGAAAMFATTLPLLGAAYQGKRRSVALGVWGAVSGGAAALGPIVGGLLTEGPGWRWIFF
                     VNLPVSVAAVWLTLRWVPKPVRAGQPGQAGQAAGAAARRVDWAGTVTFALFAGALTYGA
                     VRASAEGWTSARTGVTFAVAVLALIAFVAVERRVTHPLIDLRLLRKPAFTGVLIGAVGY
                     NAAAFGVIPYLSIWLQTVLGMSPVRGSLVLLPLAATSFVVAAIGGRLLHGAPARYVIGV
                     GLLLIGAGGLAMAVLDAGSSWSALVPGLTLAGIGTGLVAPGLAGAALASVPPKDAGMAG
                     GAVNTFRQLGYALGVAVFGTVLTSRMQDSIGQDAAHTAAGGGASALAGQVSAHDVREAF
                     AAGLNGASLTAGAVGVVAGLAVLLMVRTKPGSGAGQAPSTAPEPAPVKQLQG"
     gene            3165..4964
                     /locus_tag="EJ355_RS25450"
     CDS             3165..4964
                     /NRPS_PKS="Domain: AMP-binding (17-468). E-value: 1.3e-90.
                     Score: 295.8. Matches aSDomain:
                     nrpspksdomains_EJ355_RS25450_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676059.1"
                     /locus_tag="EJ355_RS25450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-dependent synthetase/ligase"
                     /protein_id="WP_237307578.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-88, bitscore:
                     292.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASAPRVGGLADAVFDHALEDPVRVVLGRKLDGVWQDVTSAEFRD
                     EVLALAKGLLAQGVRFGDRVAIMCRTRYEWTLFDFALWTVGAQVVPVYPTSSAEQVFWM
                     LHDAQVSAAMVEHEDHAMTIGSVVDRLPQLRRLWQLDGDAVRELSEAGRDLDDEVVHRH
                     RRAVTPDSVATVIYTSGTTGRPKGCVLTHANFMFEVDTLVERWEPVFRGRRGDEPSTLL
                     FLPLAHVFGRMVQVAAVRARVKFGHQPSLNAAALIPDFAAFRPTFILAVPYIFEKVFNA
                     ARRKADREGKAGAFDKAVEAAVRYADAMEAKAFGTGPGPSTALRMQHQVFDKLVYAKVR
                     DAMGGRVRHAMSGGSAMDRRLGLFFAGAGVQVFEGYGLTESTAAATANPPERTRYGTVG
                     QAIPGTTVHIAEDGEVWLRGGHVFQGYLNDPKATDATLHDGWLATGDLGSLDDDGYLTI
                     TGRKKEILVTSGGKSVSPAQLEERVRDHPLVAQCIVVGNDRPYIAALVTLDAEAVEHWL
                     SMRNKPPMPPGDLVRDPDLETEVRRAVVAANTLVSQAESIRTFRILAHQFTEEHGLLTP
                     SLKLKRKAIEQVYADEVEALYHT"
     aSDomain        3216..4568
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS25450_AMP-binding.1"
                     /evalue="1.30E-90"
                     /label="EJ355_RS25450_AMP-binding.1"
                     /locus_tag="EJ355_RS25450"
                     /protein_end="468"
                     /protein_start="17"
                     /score="295.8"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="ALEDPVRVVLGRKLDGVWQDVTSAEFRDEVLALAKGLLAQGVRFG
                     DRVAIMCRTRYEWTLFDFALWTVGAQVVPVYPTSSAEQVFWMLHDAQVSAAMVEHEDHA
                     MTIGSVVDRLPQLRRLWQLDGDAVRELSEAGRDLDDEVVHRHRRAVTPDSVATVIYTSG
                     TTGRPKGCVLTHANFMFEVDTLVERWEPVFRGRRGDEPSTLLFLPLAHVFGRMVQVAAV
                     RARVKFGHQPSLNAAALIPDFAAFRPTFILAVPYIFEKVFNAARRKADREGKAGAFDKA
                     VEAAVRYADAMEAKAFGTGPGPSTALRMQHQVFDKLVYAKVRDAMGGRVRHAMSGGSAM
                     DRRLGLFFAGAGVQVFEGYGLTESTAAATANPPERTRYGTVGQAIPGTTVHIAEDGEVW
                     LRGGHVFQGYLNDPKATDATLHDGWLATGDLGSLDDDGYLTITGRKKEILVT"
     CDS_motif       3681..3740
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25450_0001"
                     /evalue="6.10E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="EJ355_RS25450"
                     /protein_end="192"
                     /protein_start="172"
                     /score="28.0"
                     /tool="antismash"
                     /translation="ATVIYTSGTTGRPKGCVLTH"
     CDS_motif       4266..4316
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25450_0002"
                     /evalue="2.30E+01"
                     /label="NRPS-A_a6"
                     /locus_tag="EJ355_RS25450"
                     /protein_end="384"
                     /protein_start="367"
                     /score="-2.3"
                     /tool="antismash"
                     /translation="AGVQVFEGYGLTESTAA"
     CDS_motif       4401..4469
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25450_0003"
                     /evalue="4.90E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="EJ355_RS25450"
                     /protein_end="435"
                     /protein_start="412"
                     /score="18.9"
                     /tool="antismash"
                     /translation="GEVWLRGGHVFQGYLNDPKATDA"
     gene            complement(4990..6576)
                     /locus_tag="EJ355_RS25455"
     CDS             complement(4990..6576)
                     /GO_function="GO:0004650 - polygalacturonase activity
                     [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014058227.1"
                     /locus_tag="EJ355_RS25455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycosyl hydrolase family 28 protein"
                     /protein_id="WP_125263883.1"
                     /transl_table=11
                     /translation="MSRSTSRSRTRTGALAAGLAALAVLAVFDGQPAGATRFHDGATST
                     VRSSVPQQPSPAAEFNVRDYGAKGDGSSNDTPALQKAVDAAAAAGGGTVRLPGDGRATY
                     ESKNTLHMKSEVTLQIDKGATLSGNGADDYDPPEPNEWDDYQDYGHSHFHNAMIHGDRL
                     SDIAFVGEGVIDGDGALITGDPKSGEADKIISLTRCKGLRLGDGLTLREGGHFAALVNG
                     CDDVVSDRLTIDTAMDRDGWNVINTTDVTITNAHLDANDDALAFKSDYALGAKLSNGRV
                     RVSDSYLSAGCCNALMFGSETCGDFTDYRFERIRIEGSEKSGLGMVSMDGSKISDVHYK
                     DITMTGVRSPIMQKIGDRKRCGNNPGVGSISDVTYTDIKATGASPSFSPTLWGESGQSR
                     IKDVTFTDVDLTVPGGNGTMSTGVPSNKSTDYNPKSIGTRPAYGWYIRRADRVTFVDSE
                     VRFASNDGRPAVIANESTGIRFTAFTAQRGSSSPADLVFQRTQGYCVRDSADTGGGALR
                     ISQSGSSEDCG"
     gene            complement(6729..7847)
                     /locus_tag="EJ355_RS25460"
     CDS             complement(6729..7847)
                     /EC_number="1.1.5.-"
                     /GO_function="GO:0016901 - oxidoreductase activity, acting
                     on the CH-OH group of donors, quinone or similar compound
                     as acceptor [Evidence IEA]"
                     /GO_function="GO:0070968 - pyrroloquinoline quinone binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645350.1"
                     /locus_tag="EJ355_RS25460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PQQ-dependent sugar dehydrogenase"
                     /protein_id="WP_237307577.1"
                     /transl_table=11
                     /translation="MHDSRSSIRSRRRLVRKTALAATAALAAGLVVYVPSVSAAPAAPA
                     GEPTDIKTVSSGWTIPWGTSWLPDGKSALVTERDDFRVWSISADGATKKQVGTVPESQT
                     TGGEGGLMGVAVDPQWATNHYVYVMHTSSEGNRVARMTYDGSSLSGYTVLLKGIKKARY
                     HNGGRLAFGPDGYLYATTGDAQSKPLAQDKNSLNGKILRMTRDGKPAPGNPFDNYVYSL
                     GHRNPQGIAFDPQGRLWEAELGDATRDELNLIKPGKNYGWPTCEGNCNVSGMTNPKKTW
                     GVAEASPSGVAIVDGAVYMAALKGQRMWRIPINADNENVGTAKAFYVGQYGRLRSVTTV
                     PGAKALWLSTTNADGNGGQPDGADKIFRVTIG"
     gene            complement(7895..8704)
                     /locus_tag="EJ355_RS25465"
     CDS             complement(7895..8704)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005482488.1"
                     /locus_tag="EJ355_RS25465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_125263884.1"
                     /transl_table=11
                     /translation="MTPSRRALLAAAIGTGAGAAATAAGLAPAAAAPAADWQLRWSPSA
                     RDVGLRAFETLEDDRANSHPAAKPHIFAEGDNFRFQMHTVDRDTSTDRQRHEVTGLRNG
                     DSFLKWQKGQTWRVTYRMFLPGTLKATTSFTHIMQMKQPGAGSAPIVVQSLRRVDGKQT
                     IELKIFEQDILVGRTDLAPLHDKWTDVDFQIKIGDGSSGSVRWILKSGGTTVVDKSRSG
                     VDTFLADRVRPKWGIYRSLGDSSGSLQNTYMLLTGMRGYQLVPSAQA"
     gene            complement(8712..10001)
                     /locus_tag="EJ355_RS25470"
     CDS             complement(8712..10001)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645348.1"
                     /locus_tag="EJ355_RS25470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 88 protein"
                     /protein_id="WP_237307576.1"
                     /transl_table=11
                     /translation="MRRPGSPTSPIPARPEPAASALPGPGTPPARPHRRTARAVLAALL
                     AGCAALTAQTAPASADGTPAADRAPTARPQGTDWSVAMVESTTTRFTPATIGGWSYPVG
                     LYLFGQYQTYRRTHDERHLTYIKSYVDRFVDSEGSIGQKFNNLDSIQAGRLLVILHRET
                     GDDRYRVAARKIRDRLKTYPRTEDGGFWHADTASRAHQLWSDGVYMVTPFLVEYGKEFD
                     DETYTDREAVEQLNVYARHLQADNGLFQHAYDESRTATWADKDTGRAPEQWCRAIGWYS
                     MAAVNVLDATPRSDPGRPELLGHVRKLAAGIARAQDPATGRWFQVVNKGTESGNWTETS
                     CSSMFTFALSRAAEKGYVSPSYESVARRGHAGVLKKISLGSDGLTDLTDISIGTNVGDY
                     AFYIARPRQTNDFHGLGAFLIMNEQLRKKR"
     gene            complement(10001..11095)
                     /gene="pqqE"
                     /locus_tag="EJ355_RS25475"
     CDS             complement(10001..11095)
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645347.1"
                     /locus_tag="EJ355_RS25475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_087886475.1"
                     /sec_met_domain="PF04055 (E-value: 6.6e-23, bitscore: 77.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.4e-07, bitscore: 25.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.5e-08, bitscore: 30.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 5.3e-11, bitscore:
                     38.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPAPEPPWALLAELTHGCPLRCAYCSNPVKLNSRSAELSGGEWA
                     DVLRQAADLGVVQTHLSGGEPLLRRDLRDIVAAADAAGIHTQLVTSGVGLHEARLAGLV
                     DAGLRSVQLSVQHADPARADLIAGARATNAKERAARLVREAGLPLGLNAVLHRANLDAL
                     DALVELGLAWGADRIELANTQFYGWALRNRDALLPDPEQVARARVTLERWRVRLGDRME
                     LVWVAPDYVDATAKPCMGGWGAVSLTVAPDGTVLPCPAAADLLGADAPNVRDRTLDWIW
                     RSSPAFTRYRGEDWMREPCRSCELRTVDFGGCRCQAHALTGDAARTDPACHRSPDHGVV
                     RALVDAARRPAPDHPGYAYREGGT"
     gene            complement(11092..11697)
                     /gene="pqqD"
                     /locus_tag="EJ355_RS39840"
     CDS             complement(11092..11697)
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03859.1"
                     /locus_tag="EJ355_RS39840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_240044987.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1e-15, bitscore: 52.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 9.7e-07, bitscore: 24.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREVTVDGDAWVADGLGEGDGPGVDGWGADGPGAGGPGAGGSGAG
                     GPGAGGSGAGGSGAGGSGAGGSGAGGSGAGGSGAGGSGAGGSGNRGSDAGSSGAGGPTV
                     AHGPGGVATEPVPPDWRPVLARSVVLRRDRVRGADLLLLPERIVVLRGAAASIVALCDG
                     ERDVAGIVAELERRHPGAPVGAEVPVFLGRLRAQRWLR"
     aSDomain        complement(11098..11343)
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_EJ355_RS39840_PqqD_RRE.1"
                     /evalue="4.10E-17"
                     /identifier="RREFam006.1"
                     /label="EJ355_RS39840"
                     /locus_tag="EJ355_RS39840"
                     /protein_end="200"
                     /protein_start="118"
                     /score="52.7"
                     /tool="antismash"
                     /translation="DWRPVLARSVVLRRDRVRGADLLLLPERIVVLRGAAASIVALCDG
                     ERDVAGIVAELERRHPGAPVGAEVPVFLGRLRAQRWL"
     gene            complement(11690..12511)
                     /gene="pqqC"
                     /locus_tag="EJ355_RS25485"
     CDS             complement(11690..12511)
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645345.1"
                     /locus_tag="EJ355_RS25485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_087886474.1"
                     /sec_met_domain="TIGR02111 (E-value: 6.9e-85, bitscore:
                     279.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTVKTDAESGTGAERAPWTPDELTERLRAVSAARYHDRHPFNV
                     RMHEGTLTRAELRRWIANRFHYQRHIPVKDALILAKFDDPALRRGWSRRIRDHDGERPG
                     EGGIERWLRLGEAAGIPRAELWDTSRVLPGVRLAVDGYVNFCRLRPALDAVAASLTELS
                     APDLMRTRIAAFERHYPWIDTEGLTYFRGRVGQGGRDGQEALGLVRAWARTREEQERAV
                     AALAFKCDVLWSLLDAVSGGAPAGSSCGAFGEAAGAGAGAGAGVGEGDGDA"
     gene            complement(12508..13419)
                     /locus_tag="EJ355_RS25490"
     CDS             complement(12508..13419)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669247.1"
                     /locus_tag="EJ355_RS25490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_087886473.1"
                     /transl_table=11
                     /translation="MLLQVLGTAAGGGLPQWNCACPGCAGARAHPERRRLHASLALRAS
                     PGRWYVINATPDIGEQIEACPGLLPEAGQDADTRLSPLVGVVLTDAELDHTLGIARLRE
                     ARDGVEVLATAPVLGAVRDRLGLGAVLGPYTSTRWHELTGAGRQLNEQSAVRVAAVRVS
                     AKRPRYAEGLGPDDAAWSVALRLHDTGTGRTVLYAPALAAWTDAFEEAAREADVVLVDG
                     TFWDEEEPRRAGFSDRTATGMGHLPVAGPGGTAHRLAGLPGRCLYTHLNNTNPLGDPSA
                     EQHKQLADWGLEVAQDRMVIEL"
     gene            complement(13429..13566)
                     /gene="pqqA"
                     /locus_tag="EJ355_RS25495"
     CDS             complement(13429..13566)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_157882578.1"
                     /locus_tag="EJ355_RS25495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /protein_id="WP_125263885.1"
                     /transl_table=11
                     /translation="MNSHEMETSEVTSGSPETGPTGWQTPEYTVVETSLEVTAYRLADR
                     "
     misc_feature    complement(13719..13739)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 23.39"
                     /tool="antismash"
     gene            13814..14674
                     /locus_tag="EJ355_RS25500"
     CDS             13814..14674
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009191514.1"
                     /locus_tag="EJ355_RS25500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aldo/keto reductase"
                     /protein_id="WP_030362972.1"
                     /transl_table=11
                     /translation="MYHPTTYKDRELVSKVPPIILNNGIEMPQLGFGVWQVPDDEAERA
                     VATALESGYRSIDTAAVYENEVGTGKGIAASGIDRDKLFVTTKLWNDSQGYDSTLRAFD
                     ASLEKLGLDYVDLYLIHWPMPSADTYIDTYKAFEKILADGRAKSIGVSNFLPEHLDRLI
                     DATSVIPVVNQIELHPHLQQRASRAYHGEQGIATEAWSPLGQGKGLLEVPAIIAIAQKH
                     GRTPAQIVLRWHIQLGNVVIPKSVTPSRIKENIDVFGFELDPEDMAAISALNEDRRLGP
                     DPAEM"
     gene            complement(14687..16381)
                     /locus_tag="EJ355_RS40200"
     CDS             complement(14687..16381)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1173: WD-40
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS40200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="WD40 repeat domain-containing protein"
                     /protein_id="WP_125263886.1"
                     /transl_table=11
                     /translation="MRARDRALVQVWDVPRHRLLARPEAAVSDRGLLPALAPDGRSLLT
                     CLPGGETLEVRTLADGRGHRVTWPRQVRRQACRAGKWTVTPDSRALAFDTPDGIRTWEL
                     SPARERPRLDLPGHGEWEADFSADGATAVTTGDGVIALWRTSRPGTPLMRYAVEGDAVD
                     ARLDMKDGVVRYLVGGVVRSLDVRDALRGDRLREPLERAAFSQDGRSLAAAQRRGGTTV
                     FQLRDARDGAVTSSLSGRTCAQCRPGLFAFSRDGGTLAYTAESDGGTELRRWSVDRRRE
                     TARAVIPSYVASLLVPDGGGPVVTSGTPAGNRDNDRHYVDAWSVGERTRTRQLHRRAGD
                     EPSALSPNGRTVLARNGERITIGSGESTRVLRGEISITAVAFSPDGRHLAVAGATAGSP
                     CGTRPAPAGSVSSRSPPPARAPAPPRSSPSRPTAGTWPWGEKTAPYASGRPTPPASPEP
                     PTPAPKDPSSPSASPATNCASPPPAPPSAPSPSPRNAPPTGPANVPEAVSTATNGGRIC
                     PRWSIGGRAEGWWEEGNGTGVEGPGRAGPPAPPLNGRRRWSTGLTCP"
     gene            16380..16823
                     /locus_tag="EJ355_RS25510"
     CDS             16380..16823
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS25510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_087886470.1"
                     /transl_table=11
                     /translation="MLALLPASAALRTPQSRIDDAAAIARAVREAGASGDGLLYAPLRR
                     RAWTLPYAGATAGLDDLALARGPAASRTLYGTEVSVGVLRARMLERTRIVVAGDPNDPP
                     EGSADATGHEAVKREVLDAAFEVCRTWHSRGARVTLYARPGHC"
     gene            16904..17605
                     /locus_tag="EJ355_RS25515"
     CDS             16904..17605
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018511335.1"
                     /locus_tag="EJ355_RS25515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_087886469.1"
                     /transl_table=11
                     /translation="MAEKTIPLLPCVTVQPIVDFYTALGFETTYLQKSPYAYAVVERGT
                     VELQFFGMKQYDPAESISGCYILTDDVDSLHTAFRAGLKAAYGKIPSRGLPRIGPLKDM
                     SYGVRQFLMTDPAGNSIRVGQQISEDQAHRPAPKETFARALHLADLFVDSKEDLAGAAK
                     VIDRALALTDERPTPTQHLRLLVLRGDIAQRLGEDALAGQLLERAAGVEMTAAERAEVR
                     DALVRLEELRG"
     gene            complement(17683..18846)
                     /locus_tag="EJ355_RS25520"
     CDS             complement(17683..18846)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645338.1"
                     /locus_tag="EJ355_RS25520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_240044988.1"
                     /transl_table=11
                     /translation="MTTNGCGSAESAGEAAMTVAEHEGAAHGADAEQGRGVERGGGHGG
                     GHGGGHGHGEGHGHGGGHGHGHGHSHGHTDIDWAVMAPVLEQNAEVTAPVYREAAAWLR
                     DLRAGREGGRPAADGGPADAASADEGSADGGPAVGDPSLIVDAGSGPGVVTCLFAEVFP
                     AAQVIAADPEEALLARTVERAARLGLADRVRTHRAELPGGLGELPPADLIWAARSVHHV
                     GDQVAALTALADRLAPGGTLAILEGGLAPRSLPRDFGIGRPGLQARLDAANEEWFARMR
                     ADLPGAKEATEDWAALLTAAGLRHVATRSFLVDLPAPLPDAARDHVITTFGRYRDFAAD
                     AENPVLDADDRATLDRLLDPRDPESLHRRADLFLLTAHTVHVAVREA"
     gene            complement(18992..19735)
                     /locus_tag="EJ355_RS25525"
     CDS             complement(18992..19735)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645337.1"
                     /locus_tag="EJ355_RS25525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_125263887.1"
                     /transl_table=11
                     /translation="MLDYGKEAVRYDASRGGEPRAVAAADAVLSLLPPGTGTLLDVACG
                     TGLVTRRLAAEPGLRVVGVDAAYGMARMAADRVPGTVVLGDSRRLPFRDGAFDAAAAVW
                     LLHLLSDPDEAAAVVGECARVLRPGGVLVTTVDKAASHNVGSDIDAALAGRPVRSPVDG
                     AARVGQYAAAYGLTRAGRACFRGHGQGRSPRSTVEDLRRGWFTSVPPDSALADRFARRL
                     AELPDQEVRRPDPEFALQAFRKPLS"
     gene            complement(19932..20270)
                     /locus_tag="EJ355_RS25530"
     CDS             complement(19932..20270)
                     /EC_number="4.2.1.96"
                     /GO_function="GO:0008124 -
                     4-alpha-hydroxytetrahydrobiopterin dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006729 - tetrahydrobiopterin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020133284.1"
                     /locus_tag="EJ355_RS25530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4a-hydroxytetrahydrobiopterin dehydratase"
                     /protein_id="WP_125263888.1"
                     /transl_table=11
                     /translation="MALEPLSQKEIEDRLAELPGWSLTSAPTAAGDAAAEVKLTRAYGL
                     PSHFAATAFVVHVSQVQEELGHHAELTLGYNTVTLAVNTHSAGGALTDLDFELARRVEA
                     LATGHGAE"
     gene            complement(20426..21538)
                     /locus_tag="EJ355_RS25535"
     CDS             complement(20426..21538)
                     /EC_number="3.2.2.-"
                     /GO_function="GO:0016799 - hydrolase activity, hydrolyzing
                     N-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645334.1"
                     /locus_tag="EJ355_RS25535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ADP-ribosylglycohydrolase family protein"
                     /protein_id="WP_087886467.1"
                     /transl_table=11
                     /translation="MTNPWDPLSWEATAAYRARVRGCLLGGAVGDALGYAVEFSSLDAI
                     RAAHGPRGLRAPVVDATGVSRISDDTQMTLFTAEALRTAHARERRKGIGGAAPRLVQQA
                     YLRWLDTQHKPGPEPRPKPGTAPSDTPQGPPHPADLSSQAWLYARRAPGNACLSGAAQG
                     YAPDPALELGPHGRVNPESKGCGTVMRSAPFGLTRAPADRAFELAARCAQITHGHPTGY
                     YAAGALAAIVARLVEGDSLEGAVLRTLRLLARYPGHEETSMALTAAVDLAAAGEPSAER
                     VASLGEGWVAEEALAIGVYAALACHGVEDALLLAVNHSGDSDSTGSVCGNLLGALRGDH
                     ELPEEWVRLTEGRAVIAAVADDLAGECARR"
     gene            21567..22454
                     /locus_tag="EJ355_RS25540"
     CDS             21567..22454
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645335.1"
                     /locus_tag="EJ355_RS25540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_087886466.1"
                     /transl_table=11
                     /translation="MPTVAPRRRNSEVGPQNTRAARAKGPRAAAPSGAAEPSEVGALLR
                     AWREERRVSQLDLALRADSSARHISFVETGRAKPSEDFVLKLAEHLDVPVRERNALLLA
                     AGYAPRFKQTPLDDPSMATLRAGLEQLLQGYEPYPALVVDATYQVVAANSGIAMLLDDL
                     PEDLLAQPPNAMRLVLHPRGLAPKIRNLREWREHLLHQMGRQIALHRSAELKALYDEVA
                     AYPVADPGEDAAADGQVAPFALPLRIEHEGRTLSFVSSISTFNTPMDVTVAELAIETLL
                     PADPATVKYLQSKA"
ORIGIN
        1 ctcgcgcggc ctgatccccc cgggcctggc cagactcccg gaccgggcgg gcctgccgga
       61 gctgggttcg gtggacttcg tgctgcggca cggggagcgc ggggccgcgc gcggtgaccg
      121 gcgcgggcag ggcgccgcca gcgcggcggg cgcgctggcg gcggcgattc tggccggtgg
      181 ggaccggctg cagcgcggac cggggtgagc ggcttcgggc ggctgcgggt gcgtcgtggc
      241 cgatcgcgca gttccccgcg cccctacggg gcacccccgg accgcatgag tcgagtcaac
      301 gccccgggcg gtacgtcaac tgcttgaccc ggcgcaggaa cggcgccgtc tccacgtgct
      361 ggaccccgtc caactgcccc agcctgccgc tgatgtagcc atagagtccg gccgtgtcgc
      421 gggcgaccgc cgtcgcgacg agattcgagg gccccgccgt cgccgacgcg aaggcgatct
      481 cgaagtgacc ggcgagcgcc tcccccacgg agtgcagcgc gcccggcgcg gcggtgatcc
      541 acaggatcgc ggccgtgtgg aagccgagca tctccgggct gtactcgacg tcgacgaaga
      601 cgccccccgc gtccaggagc gccgcgagcc gccgcttcac ggcggactcg gaaagaccgg
      661 tcgcacgctg gagctggggg tacgtggcgc gcccgtccgc ttcgagggcc ttcaccaggg
      721 cctcgtcctc gggcgcgatc cgggccggac ccccgccggc ccgcgggcgg tccggggtga
      781 gcgcggcgcg ctgctcctcg gtgagcggtg cgagcttgcc gagccagccg cgcgggcccc
      841 cgaagaagct gtgcaggagc tggtgcgcgc ggatctcgac gatgctcggg gtgcgcggca
      901 gcttgccgag cagcaggtcc tcgcggtcgc cgggggtacg cggccgggtc aggcagacca
      961 cctcggtgcc gccggaggtg aggcccaccc agaaggtgtc ggggcgccgg gccagcgcgc
     1021 ccgcgatggt ggtggcgccg tcgggggcgc agcgcagccg caggatccag tggtcgcggc
     1081 ccaggcgttc ggcgttgcgc atgccgacca cgcgcaggcc gccgtcggcg gtgagccgtc
     1141 ggtagcggcg ggcgacggtc tggtcggaga cgccgaggac cttcgcgatc ttgctgaagg
     1201 acgcccggcc gtcggtctcc agggcctgga gcagcttcat gtccagctcg tccgcaccgt
     1261 ccggggtgtg gctttccatc ggctggggcc tctctgatgt cggattcgga cgccatgcgg
     1321 ccgacggcca ccgcgatcgt ccggctctga cggatcgtac gacgtcgaac gaagcacctc
     1381 acaacatcgc tgggagaacg aagatgcgca catgggggcc gctgaccgcg gtgtgcctgg
     1441 gcacattcat gctgttgctg gacgtgacga tcgtggtggt ggcgctgccc gacatggcgc
     1501 gggcgctgga cgcgtcgctg agcgatctgc agtgggtgat cgacggctac gcgctcgccc
     1561 tcgccgcgct gctgctcggg gtcggcgccg ccgccgacgt cctggggcgg cggcggatac
     1621 aggtcgcggg caccgtcgtg ttcgcgctcg cgtcgctggg ctgcgggctc gcctcgaacg
     1681 cggagatcct ggtggcggcc cgcgcggtgc aggggctcgg cgccgcggcg atgttcgcga
     1741 cgacgctgcc gctgctcggg gccgcctacc agggcaagcg gcgctcggtg gcgctcggcg
     1801 tgtggggcgc ggtcagcggg ggtgccgccg cgctcgggcc gatcgtcggc gggctgctca
     1861 cggaggggcc cggctggcgg tggatcttct tcgtgaacct gccggtgagc gtggccgcgg
     1921 tgtggctgac gctgcgctgg gtgcccaagc cggtgcgggc gggacagccg gggcaggcgg
     1981 gacaggcagc aggggctgcg gcgcggcgcg tggactgggc gggcacggtc accttcgcgc
     2041 tgttcgcggg ggcgctgacg tacggggcgg tgcgggcgtc ggccgagggc tggacgtcgg
     2101 cgcgcaccgg cgtgaccttc gccgtcgccg tgctcgcgct gatcgcgttc gtggccgtcg
     2161 aacgccgcgt cacacacccg ctgatcgacc tgcggctgct gcgcaagccc gcgttcaccg
     2221 gcgtcctgat cggggcggtc ggctacaacg cggccgcgtt cggtgtcatc ccctacctgt
     2281 cgatctggct gcagacggtg ctcggcatga gcccggtgcg cggcagtctg gtcctgctcc
     2341 cgctcgcggc gacgtcgttc gtggtggccg cgatcggcgg tcggctgctg cacggagcgc
     2401 ccgcgcggta cgtcatcggc gtcgggctgc tcctgatcgg cgcgggcggc ctggcgatgg
     2461 cggtgctcga cgccggttcc tcgtggagcg ccctggtgcc ggggctgacg ctggcgggca
     2521 tcgggacggg cctggtcgcg ccggggctcg cgggggcggc gctcgcctcg gtgccgccga
     2581 aggacgcggg catggcgggc ggtgcggtca acacgttccg gcagctcggg tacgccctcg
     2641 gcgtcgcggt gttcggtacg gtcctcacct cccggatgca ggactcgatc gggcaggacg
     2701 cggcgcacac ggccgccggg ggcggggcgt ccgcgctcgc cgggcaggtg tccgcgcacg
     2761 acgtgcggga ggccttcgcc gccgggctca acggggcgtc cctgacggcc ggtgcggtgg
     2821 gggtcgtggc gggtctcgcg gtgctcctga tggtccggac caaacccggg tccggtgcag
     2881 gtcaggcccc gtcgacggcc ccggagccgg cgcccgtgaa gcagcttcag gggtaatcgc
     2941 ccggtacaga ttcggtggag attacgccac cgaaacttac tcagccgtaa gtaatctgtc
     3001 ccacccttac ccttgtggcc gcatttcacc ggctgacctg tgacgatcgt gcgcctatgg
     3061 gcgcttccca cccccctccc gcaagggatc ggggtggggt accgtcaccg gcgctgtgcg
     3121 gagcgccaca aggagcacca ttgcgcgagt tcacgaaccc tcccatggcg tcggcgccac
     3181 gggtgggcgg tcttgccgac gccgtgttcg accatgccct tgaggatccg gtccgcgtcg
     3241 tcctcggccg caagctcgac ggggtgtggc aggacgtgac gtccgcggag ttccgggacg
     3301 aggtcctcgc gctcgccaag gggctgctcg cgcagggcgt gcggttcggc gaccgggtcg
     3361 ccatcatgtg ccgcacccgc tacgagtgga cgctgttcga cttcgccctg tggaccgtgg
     3421 gcgcgcaggt cgtgcccgtg tatccgacgt cgtcggccga gcaggtcttc tggatgctgc
     3481 acgacgcgca ggtgtcggcg gcgatggtcg agcacgagga ccacgccatg accatcggct
     3541 cggtcgtcga ccggctgccc cagctgcgcc gcctgtggca gctcgacggc gacgcggtac
     3601 gggaactctc cgaggccggc cgcgacctgg acgacgaggt ggtgcaccgc caccgccgcg
     3661 cggtcacgcc ggactccgtg gccaccgtga tctacacctc cggcaccacg ggccgcccca
     3721 agggctgcgt cctgacccac gcgaacttca tgttcgaggt ggacacgctc gtcgagcgct
     3781 gggagccggt gttccgcggc aggcgcggcg acgagccgtc caccctgctg ttcctgccgc
     3841 tcgcgcacgt cttcggccgc atggtgcagg tcgccgcggt gcgcgcccgc gtcaagttcg
     3901 gccaccagcc gagcctgaac gccgccgccc tgatccccga cttcgccgcg ttccggccga
     3961 cgttcatcct ggccgtgccg tacatcttcg agaaggtctt caacgccgcg cgccgcaagg
     4021 ccgaccggga gggcaaggcg ggagcgttcg acaaggcggt ggaggcggcg gtgcggtacg
     4081 ccgacgcgat ggaggccaag gccttcggca ccgggcccgg cccctcgacg gcgctccgca
     4141 tgcagcacca ggtcttcgac aagctcgtct acgccaaggt ccgtgacgcc atgggcggcc
     4201 gggtgcggca cgcgatgtcc ggcggctccg cgatggaccg gcgtctcggc ctgttcttcg
     4261 cgggcgcggg cgtgcaggtc ttcgaggggt acggcctcac cgagtcgacg gccgccgcga
     4321 ccgccaaccc gcccgagcgc acccgctacg gcacggtcgg ccaggccatc cccggcacca
     4381 ccgtgcacat cgccgaggac ggcgaggtct ggctgcgcgg cggccatgtc ttccagggct
     4441 acctcaacga ccccaaggcc accgacgcga ccctgcacga cggctggctc gccaccggcg
     4501 acctgggatc cctcgacgac gacggctacc tcaccatcac cggccgcaag aaggagatcc
     4561 tggtgacctc cggcggcaag agcgtgtcgc ccgcgcagct ggaggaacgc gtccgcgacc
     4621 accccctggt cgcccagtgc atcgtcgtcg gcaacgaccg cccctacatc gccgccctcg
     4681 tcaccctcga cgcggaagcc gtcgagcact ggctctccat gcgcaacaaa cccccgatgc
     4741 cccccggtga cctggtccgc gaccccgacc tggagaccga ggtgcggcgc gccgtggtgg
     4801 ccgccaacac cctggtctcc caggccgagt cgatccgcac cttccggatc ctcgcccacc
     4861 agttcaccga ggagcacggc ctgctgacgc cctcgctgaa gctcaagcgc aaggccatcg
     4921 agcaggtgta cgcggacgag gtcgaggcgc tctaccacac ctgacccgtg ccgcacgggg
     4981 cgcgggacgt cagccgcagt cctcgctcga cccgctctgg ctgatccgca gggcgccgcc
     5041 gccggtgtcg gcactgtcgc ggacgcagta gccctgggtc cgctggaaga cgaggtcggc
     5101 ggggctcgac gagccgcgct gtgcggtgaa ggcggtgaag cggatgcctg tgctctcgtt
     5161 ggcgatgacg gcgggccgtc cgtcgttcga cgcgaagcgg acctcgctgt cgacgaacgt
     5221 gacgcggtcg gcgcggcgga tgtaccagcc gtaggcgggc cgggtgccga tgctcttcgg
     5281 gttgtagtcg gtggacttgt tgctggggac gccggtggac atggtgccgt tgccgccggg
     5341 cacggtgagg tcgacgtcgg tgaaggtgac gtccttgatg cggctctgcc cggactcgcc
     5401 ccacagggtc ggcgagaagg acgggctcgc gccggtcgcc ttgatgtcgg tgtacgtgac
     5461 gtcgctgatc gagccgacgc ccgggttgtt gccgcagcgt ttgcggtcgc cgatcttctg
     5521 catgatcggt gagcgcacgc cggtcatggt gatgtccttg tagtggacgt cggagatctt
     5581 cgagccgtcc atggacacca tgccgagtcc ggacttctcc gagccctcga tcctgatccg
     5641 ttcgaagcgg tagtcggtga agtcgccgca ggtctccgag ccgaacatga gggcgttgca
     5701 gcacccggcg gagaggtagg agtcgctcac gcgcacccgg ccgttggaca gcttcgcgcc
     5761 gagggcgtag tcgctcttga aggcgagcgc gtcgtcgttg gcgtccaggt gggcgttggt
     5821 gatggtcacg tcggtggtgt tgatgacgtt ccagccgtcg cggtccatcg cggtgtcgat
     5881 ggtgagccgg tcggagacga cgtcgtcgca gccgttgacg agcgccgcga agtggccgcc
     5941 ctcgcgcagc gtgaggccgt cgccgaggcg caggcccttg caccgcgtca gcgagatgat
     6001 cttgtcggcc tcgccggact tcgggtcgcc ggtgatcagg gcgccgtcgc cgtcgatgac
     6061 gccctcgccg acgaacgcga tgtcgctgag ccggtcgccg tggatcatgg cgttgtggaa
     6121 gtggctgtgg ccgtagtcct ggtagtcgtc ccactcgttg ggctcgggcg ggtcgtagtc
     6181 gtcggcgccg ttgccggaga gcgtggcgcc cttgtcgatc tggagggtca cctcgctctt
     6241 catgtgcagg gtgttcttgg actcgtacgt cgccctgccg tccccgggca ggcgcacggt
     6301 gccgccgccc gcggcggcgg ccgcgtccac ggccttctgc agggcggggg tgtcgttgct
     6361 cgatccgtcg cccttggcac cgtagtcacg gacgttgaac tcggctgcgg gcgacggctg
     6421 ttgcggtacg gacgaccgga ccgtgctggt cgctccgtcg tggaaccgcg tggccccggc
     6481 gggctgcccg tcgaagaccg cgagcaccgc gagcgcggcg aggcccgcgg ccagggctcc
     6541 ggtgcgtgtg cgtgatctgc tcgtcgatct gctcatgtcc cgtcccctcg ctgtgcgtcg
     6601 gcggcccgcg cccgtgcggc gccgggccgt tctcgccccg gccgggccga cggtgaccgc
     6661 ccgcccccac ggcgcgcggc caccgcccgc ccggccggtg gtcatgcggc cggccggggt
     6721 cgctccggct agccgatggt cacgcggaag atcttgtccg cgccgtccgg ctgcccgccg
     6781 ttgccgtccg cgttggtcgt ggacagccac agcgccttcg cgcccggcac ggtggtcacc
     6841 gagcgcaggc ggccgtactg gccgacgtag aaggccttgg ccgtgccgac gttctcgttg
     6901 tcggcgttga tcgggatgcg ccacatgcgc tggcccttga gggccgccat gtacaccgcg
     6961 ccgtcgacga tcgccacccc gctcggggat gcctcggcga ccccccacgt cttcttcggg
     7021 ttggtcatcc cggagacgtt gcagttgccc tcgcaggtgg gccagccgta gttcttgccg
     7081 ggcttgatga ggttcagctc gtccctggtg gcgtcgccca gctcggcctc ccacaggcgg
     7141 ccctgcgggt cgaaggcgat gccttgcggg ttgcggtggc ctaggctgta gacgtagttg
     7201 tcgaaggggt tgccgggggc gggcttgccg tcccgggtca tccgcaggat cttgccgttc
     7261 agcgagttct tgtcctgcgc gagcggcttg gactgggcgt cgccggtggt ggcgtacaga
     7321 tagccgtcgg ggccgaaggc gaggcggccg ccgttgtggt acctggcctt cttgatgccc
     7381 ttgagcagca cggtgtagcc gctgagggag gagccgtcgt acgtcatgcg cgcgacgcgg
     7441 ttgccctcgg acgaggtgtg catgacgtac acgtagtggt tcgtcgccca ctgggggtcc
     7501 acggcgacgc ccatgaggcc gccctcgccg cccgtcgtct gggactcggg caccgtgccg
     7561 acctgcttct tcgtcgcgcc gtcggccgag atcgaccaga cccggaagtc gtcgcgctcg
     7621 gtgacgagcg cggacttgcc gtcggggagc caggacgtgc cccagggtat ggtccagccg
     7681 ctggagacgg tcttgatgtc ggtgggctcg cccgcgggcg cggccggggc ggccgacacc
     7741 gacgggacgt acaccacgag tcccgccgcc agtgcggccg tcgcggcgag cgccgtcttc
     7801 cggacgagac ggcgcctgct cctgatactg ctcctgctgt cgtgcacggg aacctccatg
     7861 tggggatgtg ggcgtggggg taagagcgtg gcggtcaggc ttgagccgac gggacgagtt
     7921 ggtagccgcg catgcccgtc aggagcatgt acgtgttctg cagcgagccc gaactgtcgc
     7981 cgagggagcg gtagatgccc cacttgggcc gcacccggtc ggcgaggaag gtgtcgacgc
     8041 cggacctcga cttgtcgacg acggtcgtgc cgccgctctt gaggatccag cgcacggacc
     8101 ccgacgagcc gtcaccgatc ttgatctgga agtcgacgtc ggtccacttg tcgtgcagcg
     8161 gcgccaggtc ggtgcggccg acgaggatgt cctgctcgaa gatcttcagc tcgatggtct
     8221 gcttgccgtc gacccggcgc agcgactgca cgacgatcgg cgcgctgccc gcgccgggct
     8281 gcttcatctg catgatgtgc gtgaaactcg tcgtcgcctt cagcgtgccg ggtaggaaca
     8341 tgcggtacgt gacccgccag gtctggccct tctgccactt caggaacgag tcgccgttgc
     8401 gcagccccgt gacctcgtgg cgctggcggt cggtgctggt gtcgcggtcg acggtgtgca
     8461 tctggaagcg gaagttgtcg ccctcggcga agatgtgcgg cttcgcggcg gggtgggagt
     8521 tcgcgcggtc gtcctccagg gtctcgaagg cgcgcaggcc gacgtcgcgg gcggacggcg
     8581 accagcgcag ctgccagtcc gcggcgggcg cggcggcggc cggcgcgagt cccgccgcgg
     8641 tggcggccgc gcccgcgccg gtgccgatcg ccgcggccag cagggctctg cgggaggggg
     8701 tcatgagggg ctcacctctt cttcctgagt tgctcgttca tgatcagaaa ggccccgaga
     8761 ccgtggaagt cgttggtctg ccggggccgg gcgatgtaga aggcgtagtc gccgacgttg
     8821 gtgccgatgg agatgtccgt gaggtcggtc agaccgtcgg agccgagcga gatcttcttc
     8881 aggacgcccg cgtggccgcg gcgcgcgacg ctctcgtacg acggcgacac atagcccttc
     8941 tcggcggcgc gcgacagggc gaaggtgaac atgctggagc acgacgtctc ggtccagttg
     9001 ccgctctccg tccccttgtt gacgacctgg aaccagcggc cggtcgccgg gtcctgggcc
     9061 cgcgcgatcc ccgccgccaa cttccttacg tggcccagca gttcgggtcg tccggggtcg
     9121 ctgcgcgggg tggcgtccag gacgttcacc gcggccatgg agtaccagcc gatcgcccgg
     9181 caccactgct ccggcgcccg cccggtgtcc ttgtcggccc aggtcgcggt gcgcgactcg
     9241 tcgtaggcgt gctggaacag gccgttgtcc gcctggaggt ggcgcgcgta cacgttcagc
     9301 tgctcgacgg cctcgcggtc ggtgtacgtc tcgtcgtcga actccttgcc gtactccacc
     9361 aggaacggcg tgaccatgta gacgccgtcc gaccagagtt ggtgcgcgcg actcgcggtg
     9421 tcggcgtgcc agaagccgcc gtcctcggtg cgcgggtagg tcttcaggcg gtcgcggatc
     9481 ttgcgggcgg cgacgcggta gcggtcgtcg ccggtctcgc ggtgcaggat caccaggagc
     9541 cgcccggcct ggatgctgtc gaggttgttg aacttctgcc cgatgctccc ctcgctgtcg
     9601 acgaagcggt cgacgtagct cttgatgtac gtcaagtggc gctcgtcgtg ggtgcgtcgg
     9661 tacgtctggt actggccgaa gaggtagagg ccgacggggt aggaccagcc gccgatggtg
     9721 gcgggagtga accgggtcgt cgtcgactcg accatcgcga cggaccagtc cgtgccctgg
     9781 gggcgagcgg tgggcgcccg gtcggcggcg ggcgtgccgt cggccgacgc gggggccgtc
     9841 tgcgcggtca gggcggcgca cccggcgagc agcgcggcga gcacggcacg ggccgtcctg
     9901 cggtgcggcc tcgcgggtgg tgtgccgggg ccgggcaaag cggacgcggc gggctccggt
     9961 cgggccggta tcggtgaggt gggtgagccg gggcggcgca tcaggttcct ccctcgcggt
    10021 aggcgtagcc ggggtggtcc ggtgcgggcc ggcgcgccgc gtcgaccagg gcgcgcacca
    10081 cgccgtggtc gggtgagcgg tggcaggcgg ggtcggtgcg ggcggcgtcg ccggtcaggg
    10141 cgtgggcctg gcagcggcag ccgccgaagt cgacggtgcg cagctcgcag gagcggcagg
    10201 gctcgcgcat ccagtcctcg ccgcggtagc gggtgaacgc gggcgaggac cgccagatcc
    10261 agtccagcgt ccggtcccgt acgttcgggg cgtccgcgcc gagcaggtcc gccgcggccg
    10321 ggcagggcag caccgtgccg tccggagcga cggtcaggga caccgcgccc cagccgccca
    10381 tgcacggctt cgcggtggcg tccacgtagt cgggcgcgac ccacaccagc tccatccggt
    10441 cgccgagccg gacccgccag cgctccaggg tcacccgggc acgggccacc tgctccggat
    10501 ccggaaggag cgcatcgcgg tttcgcagcg cccagccgta gaactgggtg ttcgccagct
    10561 cgatccggtc ggcgccccag gccaggccca gctccacgag ggcgtccagc gcgtcgaggt
    10621 tggcgcggtg caggacggcg ttcaggccga gcggaaggcc ggcctcgcgg acgaggcggg
    10681 cggcgcgctc cttggcgttg gtggcgcggg ccccggcgat gaggtcggcg cgggcggggt
    10741 cggcgtgctg caccgacagc tggacgctgc gcaggcccgc gtcgacgagc ccggcgaggc
    10801 gcgcctcgtg caggccgacc ccgctggtca cgagctgggt gtggatgccc gccgcgtccg
    10861 ccgctgccac gatgtcgcgc agatcgcggc gcagcagcgg ctcgccgccc gacagatgtg
    10921 tctggacgac gcccaggtca gcggcctgcc gcagcacgtc ggcccactcg ccgccggaca
    10981 gttcagctga ccgactgttc agtttgaccg ggttggagca atacgcgcag cggagcgggc
    11041 agccgtgggt cagctcggcg aggagggccc agggcggttc gggcgcgggg ctcatcgcaa
    11101 ccacctctgc gcacgcaacc ggccgaggaa caccgggacc tcggcgccga ccggcgcgcc
    11161 cgggtggcgc cgctcgagct ccgcgacgat cccggccacg tcccgctccc cgtcgcacag
    11221 cgccacgatg ctcgcggccg cgccccgcag caccacgatg cgctcgggca gcaggagcag
    11281 gtcggcgccg cgcacccggt cgcggcgcag gacgacggag cgggcgagga cgggccgcca
    11341 gtctgggggc acgggctcgg tcgcgacgcc gccggggccg tgggcgacgg tcggaccgcc
    11401 cgcgcccgag ctgcccgcat ccgagccgcg gttgcccgag ccaccggcac ccgagccacc
    11461 ggcacccgag ccacccgcac ccgagccacc ggcacccgag ccacccgcac ccgagccacc
    11521 ggcacccgag ccacccgcac ccgagccacc ggcacccggg ccacccgcac ccgagccacc
    11581 ggcacccggg ccacccgcac ccgggccgtc ggcaccccag ccgtcaacgc caggcccgtc
    11641 accctcgccc aggccgtcgg cgacccacgc atcaccgtcc acggtgacct cacgcatccc
    11701 cgtccccctc ccccacaccc gcacccgcac ccgcacccgc acccgcagcc tcaccgaaag
    11761 ccccgcagga cgaccccgca ggcgccccgc cagacaccgc gtcgagcagc gaccacagca
    11821 catcgcactt gaaggcgagc gccgccacgg cccgctcctg ctcctcgcgg gtgcgggccc
    11881 aggcgcgcac caggccgagg gcctcctgtc cgtccctgcc gccctggccg acccggcccc
    11941 ggaagtaggt gaggccctcg gtgtcgatcc acgggtagtg gcgctcgaac gcggcgatgc
    12001 gggtgcgcat gaggtcgggc gcagacagct cggtgagcga ggcggcgacg gcgtcgagtg
    12061 cgggccgcag ccggcagaag ttgacgtatc cgtcgacggc gaggcgcacc ccgggcagca
    12121 cccgggaggt gtcccacagc tccgcgcgag ggatccccgc ggcctcgccg agccgcagcc
    12181 accgctcgat gccgccctcg ccggggcgct ccccgtcgtg gtccctgatc cgccgcgacc
    12241 agccgcggcg cagcgcgggg tcgtcgaact tggcgaggat cagggcgtcc ttgacgggga
    12301 tgtgccgctg gtagtggaag cggttggcga tccagcggcg caactcggcc cgggtcaggg
    12361 tgccttcgtg catgcggacg ttgaaggggt ggcggtcgtg gtagcgggcg gcggagacgg
    12421 cgcgcagccg ctcggtgagt tcgtcggggg tccagggcgc ccgttcggcc cccgtcccgg
    12481 actccgcgtc ggtcttgacg gtcgtggtca cagctcgatc accatccggt cctgcgcgac
    12541 ttcgagcccc cagtcggcga gttgcttgtg ctgttcggcg ctcgggtcgc cgagcgggtt
    12601 ggtgttgttg aggtgcgtgt acaggcaccg tccgggcagc ccggcgagcc ggtgggcggt
    12661 gccgccgggt ccggcgacgg gcagatggcc catgccggtg gccgtgcggt cgctgaatcc
    12721 ggcccgtcgg ggttcctcct cgtcccagaa ggtgccgtcg acgaggacga cgtccgcctc
    12781 gcgggcggcc tcctcgaagg cgtcggtcca ggcggcgagc gccggggcgt acaggacggt
    12841 gcggcccgtc ccggtgtcgt gcaggcgcag ggcgacggac caggcggcgt cgtccgggcc
    12901 gaggccctcg gcgtagcgcg gccgcttggc cgaaacccgc accgcggcga cccgcactgc
    12961 tgactgttcg ttcagttgcc gccccgcccc cgtgagctcg tgccagcgcg tcgaggtgta
    13021 cgggccgagc acggcgccga gtccgaggcg gtcccggacg gcgccgagca cgggcgcggt
    13081 ggcgagcacc tcgacgccgt cgcgggcctc ccgcagccgg gcgatgccga gggtgtggtc
    13141 gagttcggcg tcggtgagga cgacgccgac gagcggggag agccgggtgt cggcgtcctg
    13201 gcccgcctcg gggagcaggc cggggcaggc ctcgatctgc tcgccgatgt cgggggtggc
    13261 gttgatgacg taccagcggc cggggctcgc gcgcagggcg agcgaggcgt gcaggcggcg
    13321 gcgttccggg tgggcgcgcg ccccggcaca gccggggcac gcgcagttcc actgggggag
    13381 tccgccgccc gctgcggtgc cgagcacctg gagcagcatc gggcgggtct accggtcggc
    13441 gaggcggtac gccgtgacct cgagcgaggt ctccacgacc gtgtactcgg gggtctgcca
    13501 gccggtgggc ccggtctcgg gagagcccga ggtgacctcc gaggtctcca tctcgtgaga
    13561 gttcatgtgc gtgtgcctac ccttcctgaa aagtgggggt tcaggagtcg ctgggacgac
    13621 atgccacgca tgtgcctagg gtgttcacat ggatggcctg cgttcagtga cgtgcaacag
    13681 agttgcgtca tggcgggacg cggtcaatgg ttcggaccga taaggtcgga gctatatcta
    13741 gccattctca gggcgccgga cagcgggaac gccacgccag gaatgcggtc cgggtcctga
    13801 tcgttgacca tggatgtacc acccgacgac gtataaggat cgagagctcg tgagcaaggt
    13861 ccccccgatc atcctgaaca acggcatcga gatgccgcag ctgggcttcg gtgtctggca
    13921 ggtgccggac gacgaggcgg agcgggccgt ggcgacggcc ctggagtccg ggtaccgcag
    13981 catcgacacg gcggccgtct acgagaacga agtgggcacc ggcaagggca tcgccgcctc
    14041 cggaatcgac cgcgacaagc tcttcgtcac gacgaagctc tggaacgaca gccaggggta
    14101 cgactcgacg ctgcgcgcgt tcgacgcctc cctggagaag ctgggcctgg actacgtcga
    14161 tctgtatctg atccactggc cgatgccgtc cgcggacacc tacatcgaca cgtacaaggc
    14221 cttcgagaag atcctcgccg acggccgcgc caagtccatc ggcgtctcca acttccttcc
    14281 ggagcacctg gaccgcctca tcgacgccac gtcggtgatc cccgtcgtga accagatcga
    14341 gctgcacccg cacctccagc agcgcgcatc ccgcgcgtac cacggcgagc agggcatcgc
    14401 cacggaggcc tggtcaccgc tcggccaggg caagggcctc ctggaggtcc cggcgatcat
    14461 cgccatcgcc cagaagcacg ggcgcacgcc ggcgcagatc gtgctccgct ggcacatcca
    14521 gctcgggaac gtggtcatcc ccaagtcggt gaccccctcc cgcatcaagg agaacatcga
    14581 cgtgttcggc ttcgagctcg acccggagga catggcggcg atcagcgccc tgaacgagga
    14641 ccggcgtctc ggccccgacc cggcggagat gtagtcctgg tcgtcctcac ggacaggtga
    14701 gcccagtgga ccatctgcgc cggccgttca gcggcggcgc aggtggtcca gctcttcccg
    14761 gcccctcgac gcctgtcccg ttcccttcct cccaccaccc ctcagcacgt ccgccgatac
    14821 tccagcgtgg gcaaatacgt ccgccattcg tcgcggtcga gaccgcctcc ggcacgttcg
    14881 caggcccggt cggcggcgcg ttccggggag agggggaggg cgcggacggg ggtgcggggg
    14941 gtggtgacgc gcagttcgtc gcgggtgaag ccgagggcga ggacgggtcc ttcggcgccg
    15001 gggtaggtgg ctccggagag gcggggggtg tcggtctccc agaggcgtac ggtgccgtct
    15061 tctcgcccca cggccaggtg ccggccgtcg ggcgagaagg cgaggaccgg ggtggcgccg
    15121 gtgcccgggc cggcggcgga ctccgcgagg acaccgagcc tgcgggtgcc ggacgcgttc
    15181 cacagggtga gcctgccgtt gccccggcca cggcgaggtg gcggccgtcg gggctgaagg
    15241 ccacggccgt gatcgagatc tcgccgcgca ggacccgggt cgactccccg gatccgatgg
    15301 tgatgcgttc cccgttccgg gccaggacgg tgcggccgtt cggggacagg gcgctcggtt
    15361 cgtcgcccgc ccgccggtgc agttgccggg tgcgggtgcg ctcgccgacg ctccacgcgt
    15421 cgacgtaatg gcggtcgttg tcgcggtttc cggccggtgt ccctgaggtg acgaccggtc
    15481 cgccgccgtc gggcaccagc aggctcgcca cgtaggaggg gatgacggcg cgtgccgtct
    15541 cccggcgccg gtcgacgctc catcgccgca gctcggtacc gccgtccgac tcagctgtgt
    15601 acgcgagggt cccgccgtcg cgggagaagg cgaagagccc tggtcggcac tgcgcgcacg
    15661 tgcgtccgga aagggacgac gtgacggcgc cgtcccgggc gtcgcgcagt tggaacaccg
    15721 ttgtcccgcc ccggcgctgg gcggccgcga ggcttcggcc gtcctggctg aacgcggccc
    15781 gctccagcgg ttcgcgcagc cggtcgccgc gcagcgcgtc gcgcacgtcg aggctgcgca
    15841 ccactccccc gaccaggtac cggaccacgc cgtccttcat gtcgagccgg gcatcgaccg
    15901 cgtcgccctc gacggcgtac cgcatcagcg gagtgccggg ccgcgacgtg cgccagagcg
    15961 cgatcacacc gtcgccggtg gtcaccgccg tggcgccgtc cgcgctgaag tcggcctccc
    16021 attcgccgtg tccgggcagg tccaaccggg ggcgctcccg ggcgggcgac agctcccagg
    16081 tgcggatgcc gtccggggtg tcgaaggcga gagcccggct gtccggcgtg acggtccact
    16141 tgccggcgcg gcaggcctgc cgccgcacct gccgcggcca cgtcacccgg tggccgcggc
    16201 cgtcggcgag ggtgcgcacc tccagggtct cgccgcccgg caggcaggtg aggagggacc
    16261 ggccgtcggg ggccagtgcc ggtagcaggc cgcggtcgct gacggcggcc tcgggccggg
    16321 ccaggagccg gtgccgcggc acgtcccaga cctggaccag ggcccggtcc cgcgctcgca
    16381 tgctcgcgct gctgcccgcg tcggccgccc tgcggacacc gcagagccgc atcgacgacg
    16441 cggcggccat cgcgcgggcg gtacgcgagg ccggggcttc cggcgacggc ctgctgtacg
    16501 caccgctgcg gcgcagggcc tggacgctgc cgtacgccgg ggccaccgcc ggcctggacg
    16561 acctggctct cgcgcgcggc ccggcggcgt cgcgcacgct ctacggcacc gaggtgtccg
    16621 tcggcgtcct gcgcgcgcgg atgctggaac ggacccgcat cgtggtggcg ggcgacccga
    16681 atgatcctcc cgaaggatcg gcggacgcca ccgggcacga agcggtgaag cgggaggtcc
    16741 tggacgccgc cttcgaggtc tgccgcacct ggcactcccg aggcgcccgg gtgaccctat
    16801 acgcccgccc cggccactgc tgagacccgg ccacccggac atcacccctc actccaccca
    16861 ctccacccac tccccctatt caactttgac tagactggcc cgcatggctg agaaaaccat
    16921 ccccctgctg ccctgcgtca ccgtccagcc gatcgtcgac ttctacaccg ccctggggtt
    16981 cgagacgacc tacctccaga agagcccgta cgcgtacgcc gtcgtcgaac gcggcaccgt
    17041 ggagctgcag ttcttcggca tgaagcagta cgacccggcc gagtcgatct ccggctgcta
    17101 catcctcacg gacgacgtgg actccctgca caccgcgttc cgcgcggggc tcaaggccgc
    17161 gtacgggaag atcccgagcc ggggtcttcc gcgcatcggg ccgctcaagg acatgtcgta
    17221 cggagtgcgg cagttcctga tgaccgaccc ggcggggaac agcatccgcg tcggccagca
    17281 gatcagcgag gaccaggcgc accggcccgc gccgaaggag accttcgcgc gggccctgca
    17341 cctcgcggac ctcttcgtcg actccaagga ggatctcgcg ggcgccgcca aggtcatcga
    17401 ccgcgccctc gccctgaccg acgaacgacc cacgcccacg cagcacctgc ggctcctggt
    17461 gctgcgcggg gacatcgccc agcggctcgg cgaggacgcg ctcgcggggc agctcctgga
    17521 gcgggccgcc ggggtcgaga tgacggcggc ggagcgggcg gaggtgcggg acgcgttggt
    17581 gcggttggag gagttgcggg ggtgaccccc ggagggtgag gggggcgagg ggtgcctccg
    17641 gtacccctcg cccgccccag ggtcacccgc ccccggaggg cctcacgcct cccggaccgc
    17701 cacgtgcacc gtgtgcgccg tcagcaggaa caggtcggcg cgccggtgca ggctctcggg
    17761 gtcccgcggg tcgaggaggc ggtcgagggt ggcgcggtcg tcggcgtcga ggaccgggtt
    17821 ctcggcgtcg gcggcgaagt cgcggtagcg gccgaacgtg gtgatgacgt ggtcccgggc
    17881 cgcgtccggc agcggcgcgg gcaggtcgac gaggaagctg cgcgtcgcca catggcgcag
    17941 gccggccgcc gtcagcagcg cggcccagtc ctccgtcgcc tccttcgcgc ccggcaggtc
    18001 ggcccgcatc cgcgcgaacc actcctcgtt ggccgcgtcc aggcgggcct ggaggccggg
    18061 gcggccgatg ccgaagtcgc gcgggaggct gcgcggcgcg aggccccctt cgaggatcgc
    18121 gagcgtgccg cccggcgcga gccggtccgc gagcgccgtc agagcggcca cctggtcgcc
    18181 cacgtggtgc acggaacggg ccgcccagat gaggtcggcg ggcggcaact cgcccaggcc
    18241 gcccgggagt tccgcgcggt gcgtgcgcac ccggtccgcg aggccgagcc gcgccgcgcg
    18301 ctccaccgtg cgcgcgagca gggcctcctc ggggtccgcc gcgatgacct gcgccgccgg
    18361 gaacacctcg gcgaacaggc aggtgacgac gcccgggccg ctgcccgcgt cgacgatcag
    18421 ggacgggtcg ccgacggccg gacccccgtc ggccgaaccc tcgtcggcgg aggccgcgtc
    18481 ggcaggacct ccgtcggcag cggggcggcc gccctcgcgt cccgcgcgca ggtcgcgcag
    18541 ccaggccgcc gcctcacggt agacgggggc cgtgacctcc gcgttctgct cgagcacggg
    18601 cgccatgacg gcccagtcga tgtcggtgtg cccgtggctg tgcccatgac catggccatg
    18661 accgcccccg tggccatgcc cctcgccgtg cccgtgaccg ccaccgtggc cgccaccgtg
    18721 accgccgccg cgttcgaccc cgcgcccctg ctccgcgtcc gccccgtgcg ccgcaccctc
    18781 gtgctccgcc accgtcatcg ccgcctctcc tgcgctctcg gcgctaccgc acccgttcgt
    18841 ggtcacgtcg ccagcctgcg ccctcccctc cggatacggc cagccgtgtt gccgttccgg
    18901 caaagagggg cctgggtggc ggcccgaccc cggggggcct gtgccgccga ccgcggagcg
    18961 aaggtgcgcg ggcgttgtcg gcgcccgccc ctcagctcag cggcttgcgg aacgcctgga
    19021 gtgcgaactc cgggtcggga cgccggactt cctggtccgg gagctccgcg aggcggcgcg
    19081 cgaagcggtc cgccagggcg ctgtccggcg ggacactcgt gaaccagccc cggcgcaggt
    19141 cctcgaccgt gctgcggggg ctgcggccct ggccgtggcc ccggaaacag gccctgcccg
    19201 cccgggtgag gccgtacgcg gccgcgtact gcccgacgcg ggcggccccg tccaccggtg
    19261 accggaccgg gcggcccgcg agcgccgcgt cgatgtcgct gcccacgttg tgcgaggcgg
    19321 ccttgtccac ggtggtgacg aggaccccgc cgggccggag cacccgcgcg cactccccga
    19381 cgacggccgc cgcctcgtcc gggtcggaca acaggtgcag cagccacacc gcggccgccg
    19441 cgtcgaacgc gccgtcgcgg aacggcagcc ggcggctgtc cccgagcacg acggtgccgg
    19501 gaacccggtc ggccgccatc cgggccatgc cgtacgccgc gtccacgccc accacccgca
    19561 gccccggctc cgccgcgagg cgccgcgtca ccaggcccgt gccacaggcc acgtcgagca
    19621 gcgtgcccgt ccccggcggc agcagcgaca gcaccgcgtc ggcggcggcc acggcccgtg
    19681 gctcaccccc gcgcgacgcg tcgtaccgca ccgcctcctt gccgtagtcg agcatcaggc
    19741 acccgctccg cacctcgcgc ggcccctgcc gggcccgggg cccggcggac ggcttcccgc
    19801 cggccgcgaa ccgggcgggc gccgcatggc cgtgacggcc ccgggcgcca cggcccgggc
    19861 cgacccgggc accacagccc cgaccgaccc ggcagcctgt ggcgtcccac cccgccccgt
    19921 cgcgtcccgc atcattccgc tccgtggccc gtcgccagcg cctcgaccct gcgggccagt
    19981 tcgaagtcga ggtcggtgag tgcgccgccc gcgctgtggg tgttcacggc gagggtcacg
    20041 gtgttgtagc cgagggtcag ctcggcgtgg tggccgagct cctcctggac ctgggagacg
    20101 tgcacgacga acgcggtcgc cgcgaagtgc gagggaaggc cgtaggcgcg ggtgagcttc
    20161 acctcggcgg cggcgtcgcc ggccgcggtg ggggccgacg tgagcgacca gccgggaagc
    20221 tccgcgagcc ggtcctcgat ctccttctgc gacagcggtt cgagagccat ggctgcgctc
    20281 cttcctgcgt ttgtgcgggt gtggaccctg tcgtgccagc gtgccacagg acctgccgcg
    20341 cggagcgccg acggcgcgcc ccttcgcgtc accgccgcac acatccggcc gcgacgacac
    20401 cgcccccgcc ccgcccggcg ggccctcagc gccgggcgca ctcccccgcc aagtcgtccg
    20461 ccaccgccgc gatcaccgcg cgcccctcgg tcaaccgcac ccactcctcg ggcagttcgt
    20521 ggtcgccgcg cagcgccccg agaaggttcc cgcagacgga tccggtggag tcgctgtcgc
    20581 ccgagtggtt cacggcgagg agcagcgcgt cctcgacgcc gtggcaggcg agggcggcgt
    20641 acacgccgat ggccagggcc tcctcggcga cccagccctc gcccagggac gcgacgcgct
    20701 ccgcgctcgg ctcgcccgcg gcggccaggt cgacggcggc ggtcagggcc atggacgtct
    20761 cctcgtgccc ggggtaccgg gcgagcagcc gcagggtgcg caggacggcg ccctccaggg
    20821 agtcgccctc gacgaggcgc gcgacgatcg cggcgagcgc gcccgccgcg tagtagcccg
    20881 tcgggtggcc gtgggtgatc tgggcgcagc gcgcggcgag ttcgaaggca cggtcggcgg
    20941 gtgcgcgcgt gaggccgaag ggcgccgagc gcatcacggt gccgcacccc ttggactcag
    21001 ggttgacgcg gccgtgcggg ccgagctcca gggcggggtc gggcgcgtac ccctgcgccg
    21061 ctccgctcag gcaggcgttg ccgggggccc gccgggcgta cagccaggcc tgggagctga
    21121 ggtcggcggg gtgcgggggt ccctgcgggg tgtccgaagg ggcggtgccg ggcttcggcc
    21181 ggggctccgg gcccggcttg tgctgggtgt caagccagcg cagatacgcc tgctgcacca
    21241 gccgcggcgc cgcgcccccg atgcccttgc ggcgctcgcg tgcgtgcgcg gtccgcaggg
    21301 cctcggcggt gaacagcgtc atctgggtgt cgtcgctgat ccggctgacg cccgtcgcgt
    21361 cgaccaccgg tgcccgcagc ccacgcgggc cgtgcgcggc gcggatggcg tcgagggagc
    21421 tgaactcgac cgcgtacccg agcgcgtcac cgaccgcgcc gccgagcaga cagccccgca
    21481 cccgggcccg gtacgcggcg gtggcctccc acgacagcgg gtcccacgga ttcgtcatgc
    21541 gctcctcctc gattaccgtc tttgccatgc caactgtcgc gcctcgccgc cggaacagtg
    21601 aagtcggccc ccagaacacc cgggccgccc gtgccaaggg tccacgcgcc gccgcgccgt
    21661 ccggtgcggc cgagccgtcc gaggtgggcg cgctgctgcg cgcctggcgt gaggagcggc
    21721 gcgtcagcca gctggatctc gccctgcgcg cggactcctc cgcgcgccac atcagtttcg
    21781 tggagacggg ccgcgccaag cccagcgagg acttcgtcct gaagctcgcc gagcacctgg
    21841 acgtgcccgt gcgcgaacgc aacgcgctgc tgctcgccgc cgggtacgct ccccgtttca
    21901 agcagacgcc cctggacgac ccgtcgatgg ccacgctgcg cgccggtctc gaacagctcc
    21961 ttcagggcta cgagccgtat ccggcgctgg tcgtcgacgc cacgtaccag gtggtcgccg
    22021 cgaacagcgg catcgcgatg ctcctcgacg acctccccga ggacctgctc gcacagcccc
    22081 cgaacgcgat gcggctcgtc ctgcacccgc gcggcctcgc cccgaagatc cgcaatctgc
    22141 gggagtggcg cgagcacctg ctgcaccaga tggggcggca gatcgccctg caccggtcgg
    22201 cggagctgaa ggcgctgtac gacgaggtgg cggcgtaccc cgtggccgat cccggcgagg
    22261 acgcggccgc cgacgggcag gtggcgccct tcgcgctgcc gctcaggatc gagcacgagg
    22321 gccggacgct gtccttcgtg tcgtcgatct ccacgttcaa cacgccgatg gacgtgaccg
    22381 tcgccgagct ggccatcgag accctgctcc cggccgaccc ggcgacggtc aagtacctcc
    22441 agtcgaaggc gtagcccggg ggcgccgggc acccccgggg cgtcccggcc gcccggtgcc
    22501 ggtcgccgtc a
//
