LOCUS       NZ_RHGC01000006        22217 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig006, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000006
VERSION     NZ_RHGC01000006.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 821110)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 821110)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 284646
            Orig. end                         :: 306863
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000006.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22217
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="5"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22217
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22217
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12217](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12217
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            811..1731
                     /locus_tag="EJ355_RS25075"
     CDS             811..1731
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_ER (21-243). E-value: 1.1e-39.
                     Score: 128.3. Matches aSDomain:
                     nrpspksdomains_EJ355_RS25075_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020126080.1"
                     /locus_tag="EJ355_RS25075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADP-dependent oxidoreductase"
                     /protein_id="WP_087886533.1"
                     /sec_met_domain="ADH_N (E-value: 4.4e-11, bitscore: 38.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.5e-13, bitscore:
                     46.3, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKAYAFTRHGGPEVEALIDREPPEPGPGQLLVKVRAAGVNPVDH
                     KLRGGYRRPGQAPAELPEVLGSEASGVVERTGPGVEGFAVGDAVFGSTLTGGYAEYTLL
                     PVTVAARVPEGLSFVEAATLPVAAATAYDGVRQLALPAGSTLLVTGAGGGVGGNAVRLA
                     RHLGLRVVGTASDAKKDVVESLGAVHVAPGPDLVERIRAAAPDGVDGVFDLVGGDHLRA
                     VADVVADRTKLITAGGKQIVTELGGSAVARARDAATLDAVAELAASGVLRPHITATYPL
                     DRAGEALRAVESGHALGKVVIEVGP"
     aSDomain        874..1539
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS25075_PKS_ER.1"
                     /evalue="1.10E-39"
                     /label="EJ355_RS25075_PKS_ER.1"
                     /locus_tag="EJ355_RS25075"
                     /protein_end="243"
                     /protein_start="21"
                     /score="128.3"
                     /tool="antismash"
                     /translation="EPPEPGPGQLLVKVRAAGVNPVDHKLRGGYRRPGQAPAELPEVLG
                     SEASGVVERTGPGVEGFAVGDAVFGSTLTGGYAEYTLLPVTVAARVPEGLSFVEAATLP
                     VAAATAYDGVRQLALPAGSTLLVTGAGGGVGGNAVRLARHLGLRVVGTASDAKKDVVES
                     LGAVHVAPGPDLVERIRAAAPDGVDGVFDLVGGDHLRAVADVVADRTKLITAGGKQIVT
                     "
     CDS_motif       1003..1041
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25075_0001"
                     /evalue="2.20E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="EJ355_RS25075"
                     /protein_end="77"
                     /protein_start="64"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LGSEASGVVERTG"
     CDS_motif       1171..1206
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25075_0002"
                     /evalue="4.30E-03"
                     /label="PKSI-ER_m4"
                     /locus_tag="EJ355_RS25075"
                     /protein_end="132"
                     /protein_start="120"
                     /score="10.7"
                     /tool="antismash"
                     /translation="AATLPVAAATAY"
     gene            1887..2390
                     /locus_tag="EJ355_RS25080"
     CDS             1887..2390
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014136824.1"
                     /locus_tag="EJ355_RS25080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="FBP domain-containing protein"
                     /protein_id="WP_087886532.1"
                     /transl_table=11
                     /translation="MRALGDKEIRASFVNCSKGEARRLTLPAGFAETPWSDLDFLGWRD
                     PKAPDRGYVVAERGEDLVGIALRASTGARRSMLKSSICSVCVTPQAGSGIALLVAPRAG
                     EAGRQGNSVGLYVCADLACSLYVRGKKTSALARRFDESLTPEEQNDRTVRNLNGFLDQV
                     LARA"
     gene            complement(2387..2836)
                     /locus_tag="EJ355_RS25085"
     CDS             complement(2387..2836)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016645232.1"
                     /locus_tag="EJ355_RS25085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S) ferredoxin domain-containing protein"
                     /protein_id="WP_237307583.1"
                     /transl_table=11
                     /translation="MTVPEPRTAPAVLLPDPRTAPDTVPPTTPPAPRPCTLVVCRGCCC
                     GDPVKHPGTDHVGQLARLQAAADASGGRFAVRTSDCLGPCGQANIVVVQPSRTGRAHGG
                     RPAWVGFALDDASLDDILTWAEAGGPGLADPPDALTLQLVDPRQV"
     gene            complement(2860..4200)
                     /locus_tag="EJ355_RS25090"
     CDS             complement(2860..4200)
                     /EC_number="3.2.1.86"
                     /GO_function="GO:0008706 - 6-phospho-beta-glucosidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019058990.1"
                     /locus_tag="EJ355_RS25090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="6-phospho-beta-glucosidase"
                     /protein_id="WP_087886531.1"
                     /transl_table=11
                     /translation="MRLAILGGGGFRVPLVYRALLGDRAEGRVTEVVLYDVEGARAAAI
                     ARVLADQAAGVADAPTVIVTADLDEALRGADFVFSAIRVGGLEGRAADERVALAEGVLG
                     QETVGAGGIAYGLRTLPVAVDIARRVRRLAPEAWVINFTNPAGLVTEAMARHIGDRVIG
                     ICDSPVGLGRRIAGLLGAEPRRARLDYVGLNHLGWLSGLEVEGEDLLPRLLADRGLLES
                     FEEGKLFGADWLQSLGVIPNEYLHYYYFNRETVHAYRSAERTRGAFLRDQQARFYEEMR
                     SPGTPAFKTWDATRAEREATYMAHSREAAGAGERAPEDMESGGYEQVALALMRAIARDE
                     HATLILNVRNRTTLPELDSDAVIEVPCTVDASGPHPVAVSPLPGHATGLVCAVKAVERE
                     VLAAADSGSRATAVKAFALHPLVDSVSVARRLVDGYRQAHPGLAYLT"
     misc_feature    4341..4354
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.17"
                     /tool="antismash"
     misc_feature    complement(4341..4354)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 17.55"
                     /tool="antismash"
     gene            complement(4353..4856)
                     /locus_tag="EJ355_RS25095"
     CDS             complement(4353..4856)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 4HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644768.1"
                     /locus_tag="EJ355_RS25095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase family protein"
                     /protein_id="WP_087886530.1"
                     /sec_met_domain="4HBT_2 (E-value: 9.3e-31, bitscore: 102.2,
                     seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTREIARRLAFHRQVVPPEWIDYNGHMSEGYYSLAFGFATDAMMD
                     ATGLDAAYREATGCSLYTVEAHLRYLRDVAEGARLAVRTRVLGVHGKKAHFTHELYVVD
                     GAAADPAPDAAPVATTELLALHVDQKAGRAVPFPDAIRERLAEFVEAAPEWAGRAIAAV
                     AATE"
     gene            complement(4853..5836)
                     /locus_tag="EJ355_RS25100"
     CDS             complement(4853..5836)
                     /GO_function="GO:0070403 - NAD+ binding [Evidence IEA]"
                     /GO_process="GO:0006631 - fatty acid metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644767.1"
                     /locus_tag="EJ355_RS25100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-hydroxyacyl-CoA dehydrogenase NAD-binding
                     domain-containing protein"
                     /protein_id="WP_087886529.1"
                     /transl_table=11
                     /translation="MTTTTPEDVRRVACVGAGVIGGGWVAHFLARGYDVTAWDPAPDAE
                     ARLRRLVDAAWPALTRLGLAEGASQDRLTVAATLEEAVADAQFVQESAPEKLELKRDLL
                     TRLDAAAPPGVVIASSTSGYPMTDMQTTAADPGRLVVGHPFNPPYLIPLVEVVGGERTT
                     AEAVAWASRFYEVAGKSVITMKSEVPGFIANRLQEALWREALHMVANGEATVQEIDDSI
                     TEGPGLRWAFMGPMLTFALAGGEGGMAHMLDHFGPSLKSPWTRLEAPELDKDLYDAVVA
                     GCDEAAAGRTIADLVAERDQGVIDVLRATGRLPRQAAGHAEPKGTM"
     gene            complement(5908..6810)
                     /locus_tag="EJ355_RS25105"
     CDS             complement(5908..6810)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018514929.1"
                     /locus_tag="EJ355_RS25105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-keto-5-aminohexanoate cleavage protein"
                     /protein_id="WP_125263856.1"
                     /transl_table=11
                     /translation="MPVNDHVIITCALTGAGDTVRKSPHVPVTPEQIARDAVRAAEAGA
                     AVVHIHVRDPETGAPSRDPRLYREVVERVKETGTDVVINLTAGMGGDLVVDPEQPLKGL
                     GELPGTDLVGGLDRLPHVEDLLPDICTLDCGSLNFGDGSNLYVSTPDMLRQGARRIQEL
                     GVRPELEIFDTGQLWFAKQLLAEGLLDDPTVFQLCMGIPWGAPADPGVLQSMVNMLPEG
                     AQWASFAIGRMQMPWVAQSILLGGQVRVGLEDNLYLGKGNKVSNAQLVERAVQITESLG
                     SRVATPDEARLKLGLKPRV"
     CDS             complement(6986..>7635)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=2
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454375.1"
                     /locus_tag="EJ355_RS25110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_240044985.1"
                     /transl_table=11
                     /translation="GGAGPAAARPAVPRGRRAATPPEGRPLQIIRETVRLIADHGFHAV
                     RVQDIAKACETSTAAIHYHFPGRDDLLEAAARWCMDEDTARRAARIADAADAADELRQL
                     IELQTPRTAQQRDQWSVWLDLWAEAARSTAVGRLHTEYYRQWRATVADVVRRGVAQGAF
                     RTVDPEAAALHLTALIDGLAAQVLAGTPEGPGTRPDDMHAALLAHVDAALAAR"
     gene            complement(6986..>7637)
                     /locus_tag="EJ355_RS25110"
     assembly_gap    7638..7647
                     /estimated_length=10
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
     gene            complement(<7648..7800)
                     /locus_tag="EJ355_RS39835"
     CDS             complement(<7648..7800)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003970968.1"
                     /locus_tag="EJ355_RS39835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_240045007.1"
                     /transl_table=11
                     /translation="MEQDPDVPTRVREVIAAAGVTQREFARRIVMDPSKLSRSLSGTRR
                     FTAAEL"
     gene            complement(7901..9106)
                     /locus_tag="EJ355_RS25115"
     CDS             complement(7901..9106)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010043723.1"
                     /locus_tag="EJ355_RS25115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_240044986.1"
                     /transl_table=11
                     /translation="MVLLLAVACGVAVGNIYFPQAVSPLVASGLDVSGDTAALVVTAAQ
                     FGYALGIFFLVPLGDRVPHRTLIATLFALSGAGLLAASAAPALPPLLGASVLVGVTTVV
                     APVVAPMAAGLVPAERRGAVTGTLLSGSIGGMLLSRAFGGALGEWLGWRAPYLVTAVVA
                     LLIGAVLARSLPRTVPTSSQRYPALLAESLRLLRTEPLLRLSCFYQATAFAAFQALWTG
                     VALFLTSGTYGLGASAVGALALVNAGTMLATPFAGRQIDRRGPDAVNAVCLVAVVASAG
                     VLALGGLGGVAGLVGLALGTLLLDVAMQSGMVANQVRIFALSGEARSRLNTAYMTCAFI
                     GGAAGSSLGALAYATLGWAGVCGWVAVLGVVSAPVAVRRGWVRTGPRGGPGRPGRQGHC
                     AD"
     misc_feature    9602..9620
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 23.16"
                     /tool="antismash"
     misc_feature    9861..9876
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.99"
                     /tool="antismash"
     gene            10001..12217
                     /locus_tag="EJ355_RS25120"
     CDS             10001..12217
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0010333 - terpene synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0046246 - terpene biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644104.1"
                     /locus_tag="EJ355_RS25120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="terpene synthase family protein"
                     /protein_id="WP_125263857.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-83, bitscore: 276.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQPSRPFELPSFYMVHPARLNPHTEQARAHTREWARDMGMLEGS
                     GVWDTADLEAHDYALLCAYTHPDCDSAALSLVTDWYVWVFFFDDHFLELFKRTQDRVGG
                     KAYLDRLPAFMPMDLATPMPEPTNPVEAGLADLWKRTVPSMSLQWRARFAESTRNLLNE
                     SLWELSNINAHRVANPVEYIEMRRKVGGAPWSAGLVEYATGAEVPAAVAASRPLRVLRD
                     TFSDAVHLRNDLFSYQREVEEEGELSNGVLVLETFLGCSTQEAADAVNDLLTARMQQFE
                     ETTFTELAPLCAEKALTPRQSADVLAYVKGLQDWQSGGHEWHMRSSRYMNEGAVDRPSP
                     LAGPTGVGTSAAGIKALMAATGAQRARRFTHVPYQRVGPSVIPDFDLPYTTTLSPHLDA
                     SRREVVDWAARMGMLEPQPGVPASHIWDARKLAGYDFPLCAAGLHPDATPEQLDIGSCW
                     LTWGTYGDDYYPVVFGRPRDLLGAKVCNDRLLLFMPLDCSPTPPPANALERGLADLWAR
                     TAGPMDAGGRALLHRTLVDMTDSWLWELANQAQNRIPEPVDYMEMRRHTFGAHFTMSLS
                     RFGHGKRVPQEIYASGPMQNLENAAADYSMLMNDVFSYQKEIEYEGEVHNAILVVQNFF
                     DCDYPAALGIVDDLMRSRMSQFQHVVAHELPVLYDEFDLDQEVRDILDGYVQELKNWMA
                     GIFVWHRDCRRYRQEDLSHGPLPEPSGLGMEVVRPGWLRELAAP"
     gene            12321..12776
                     /locus_tag="EJ355_RS39005"
     CDS             12321..12776
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS39005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_125263858.1"
                     /transl_table=11
                     /translation="MREPNHVHPATPGAPARWLTVAPERTVLGVIHNVTSATRLLDLLT
                     VFDGDRRVQTVFTCTGSSPFADGVAEFAAARELPFPPWDEAVKAEFDLAVGTSRGGALH
                     RISAPLMGAPHGAGYNKRLSSREPGAGSREPGAGSREPGAGSREPSA"
     gene            12806..14161
                     /locus_tag="EJ355_RS25130"
     CDS             12806..14161
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS25130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_153188911.1"
                     /transl_table=11
                     /translation="MIPSAIVLSHEEQLARLRVGCPEALPVAHVVGDPCMDRLRASLPF
                     RAEYRAALGVRPDQHLLVLSSTWGRGSLLGAAGDLVLRALAELPHDSFRVLAAVHPNAW
                     YGHGGWQLRSWLRPHLDAGLLLPPPADDTWQAALCAADAFVGDHGSVTLYAAGLGLPGL
                     LGAFDEDSVAADSPMAALGEALPRVSPARPLAAQLERAARDQPTDPRLAAVTSQITSHP
                     GEAPARLRRLCYRMLDLDEPAAPLAPRPVDVPRDLPSAPRPPVERPLFVEALVTSGDGD
                     DATTGPHPPLEPAGPTEVLIRRHPAHVRAAATPHPPLTDAHLSVTAGEPDARWAHAADV
                     VTARAPASGPHLAALTDELFAAHPGCVLVAVEQEDGRCLLRTRNGASFHGCWESPPAWA
                     TTSLTASAVYAWLLRHGESLAGEVLVRLTPDGVPARLRVWRLGTNSALHSAS"
     gene            complement(14165..16411)
                     /locus_tag="EJ355_RS39010"
     CDS             complement(14165..16411)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS39010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_125263860.1"
                     /transl_table=11
                     /translation="MANNISGGTFRDVIQAGHVTVRQCVSGEVRAPRVPFMAPAAPGRL
                     VDRLPVRAALDRAADARPVRAAAEVAVVTGPPGIGKSGAVLHWSARRRGDFPGGVLYAD
                     MSPRGALEPADTRSVLESFVAALGTPRAEMPADPAPLAAYYRHLTAHEPCLVLLDDVVT
                     AGQVPPLLPGHPKSMVVITSRLLLNGLRPVLPGSEPVYVRLAGLDDESCRELFLDTAGR
                     ETAAELTDRGQELLRTVIPAFAGLPAAARLAGARAADPLEGGVEEFVRRLLALPTFQEA
                     LTVPDDPHTYSLRSVFEDSYAALEPATAAVFRGLGLNPTPEFADALVDALAGGPEAGAR
                     ARRTLLNGNLLERPAPGRCRMNGLLHEYAAALARTDAAEAAAVAARITDWYLRRAAAAE
                     RLVSGRWRRAAIFRDPTVLDGVFGSEAEALDALEADRENAAALTGLEFTRGHDLLVCDL
                     AEALRGFFFRRKHHTLWVEVAERGVRAAERMVEARAADAADAAGAGPGPAAGGAEDAGA
                     AGVAETPDDASLVLARCHYELAFALFDQGGAHSVERAGHHYGLALSQARAAGHARTESS
                     ALEGLGQVAVEQGRPQDALDCFRQALRALGDLAHPRGRALLQYHMGRAASAARLHEEAA
                     EALLGARRLFAELPVPDRYNEARALTRYAQARLAADRADEAVAPLDEAITLLRERGAPK
                     EEADARLARGDAWAVRGDETRAREDWRAALDTYRTLGSVAAAGARERLGEGGDS"
     misc_feature    complement(15707..15709)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16497..18140)
                     /locus_tag="EJ355_RS25140"
     CDS             complement(16497..18140)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644101.1"
                     /locus_tag="EJ355_RS25140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cytochrome bc complex cytochrome b subunit"
                     /protein_id="WP_030360217.1"
                     /transl_table=11
                     /translation="MSERARNTGPGTRDPGPGKGERVADWADGRLGVHTLAKTQMRKVF
                     PDHWSFMFGEICLYSFLILILTGVWLTLFFEPSGLEVEYNGSYEPLKGVVMTRAYESTV
                     DISMEVRGGLLIRQIHHWAALVFVAGMLVHMMRVFFTGAFRKPRELNWVFGWTLLMLGL
                     ITGLTGYSLPDDLLSGTGIRFAQGAILSIPVIGTYLSFFLFGGEFPGHDIIPRLFAVHV
                     LLLPGIMLGLVVAHLILVFYHKHTQFAGPGRTEKNVVGAPFLPIYIAKAGGFFFLVFGV
                     LAMMGAVATINPVWALGPYRPDLVGTGAQPDWYLGFSEGLIRVMPSWEINAWGHTLQLG
                     VFIPFALFPLIMAAIGAYPFIESWVTKDRREHHIADRPRNAPVRTGLGVAWLTLYGVLM
                     VGGGNDLWATHFHLSINAITWFVRVAFFVAPPLAFVVTHRICLGLQRRDRDKVLHGRES
                     GIIKRLPHGEYVEVHEPLSQAERYRLTAHEQPQPHEVGPLVDANGVARKVPRSERLRAR
                     LSRAMYGPGAQVPKATAEEYRRIHSGDGHH"
     gene            complement(18245..19390)
                     /gene="dgoD"
                     /locus_tag="EJ355_RS25145"
     CDS             complement(18245..19390)
                     /EC_number="4.2.1.6"
                     /GO_function="GO:0008869 - galactonate dehydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009063 - amino acid catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dgoD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268: mandelate racemase/muconate lactonizing enzyme"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676976.1"
                     /locus_tag="EJ355_RS25145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="galactonate dehydratase"
                     /protein_id="WP_087886522.1"
                     /transl_table=11
                     /translation="MKIDRVETFLVPPRWLFCRVETDTGVVGWGEPVVEGRAEVVRAAV
                     DVLAEYLVGKDPLRIQDHWQVLTKGGFYRGGPVLSSAVAGIDQALWDIAGKTYGAPVHA
                     LLGGPVRDRARVYAWVGGDEPAVLAEHIAEQVEAGFTAVKMNAAGATSPLTTPAETAAV
                     VDRVAIAREALGPDRDVAVDFHGRFTPASARRVLAELAPLHPLFAEEPLPPDLGHLLPA
                     LVAAGPVPIATGERLYSRAEFLPALTAGIAVAQPDLSHAGGITEVQRIAALAETHGALL
                     APHCPLGPIALAASLQLAFTTPNFLIQEQSRGIHYNKSADLLSYVVDTEPFRFTDGYAH
                     RTALPGLGVEVDEAAVRAADRSGHAWRNPVWRHPDGSFAEW"
     gene            complement(19506..20318)
                     /locus_tag="EJ355_RS25150"
     CDS             complement(19506..20318)
                     /NRPS_PKS="Domain: PKS_KR (28-189). E-value: 4.1e-15.
                     Score: 48.1. Matches aSDomain:
                     nrpspksdomains_EJ355_RS25150_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676974.1"
                     /locus_tag="EJ355_RS25150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_125263861.1"
                     /sec_met_domain="adh_short (E-value: 2.4e-32, bitscore:
                     107.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSAVAAHPYEGTPHVNPSAPASRFTGKVAVVTGGASGIGAATAV
                     RLAAEGAAVVVSDVDADHGEPVAEGIRAGGGSAVFVRADVADAADWDQVLAAAHSFGPV
                     GVLSSNAYACEVAPAHAMTQASWEHQLAVNLTGTFLGVKAVLPDLRAHRGAVVLTSSVH
                     ARTGIPGRPAYAASKGALVSLCGQLAVEYGPEVRVNAVLPGPILTPAWGNVGEDDRARS
                     VEGTAAGRFGAPEEVAAAIAFLAADEASYITGTSLTVDGGWSVVKDSA"
     aSDomain        complement(19752..20234)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS25150_PKS_KR.1"
                     /evalue="4.10E-15"
                     /label="EJ355_RS25150_PKS_KR.1"
                     /locus_tag="EJ355_RS25150"
                     /protein_end="189"
                     /protein_start="28"
                     /score="48.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAVVTGGASGIGAATAVRLAAEGAAVVVSDVDADHGEPVAEGIRA
                     GGGSAVFVRADVADAADWDQVLAAAHSFGPVGVLSSNAYACEVAPAHAMTQASWEHQLA
                     VNLTGTFLGVKAVLPDLRAHRGAVVLTSSVHARTGIPGRPAYAASKGALVSLCGQLA"
     CDS_motif       complement(20151..20228)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS25150_0001"
                     /evalue="2.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="EJ355_RS25150"
                     /protein_end="56"
                     /protein_start="30"
                     /score="17.1"
                     /tool="antismash"
                     /translation="VVTGGASGIGAATAVRLAAEGAAVVV"
     gene            complement(20485..21354)
                     /locus_tag="EJ355_RS25155"
     CDS             complement(20485..21354)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644097.1"
                     /locus_tag="EJ355_RS25155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="metallophosphoesterase"
                     /protein_id="WP_087887959.1"
                     /transl_table=11
                     /translation="MTTSAASRRAPRLFGISDLHIAYAENRKFVDELWPEHEGDWLIVA
                     GDIGEMMSDIEWALRTLTERFDTVIWSPGNHELWTPRDDPNQLRGEARYRHLVELCRSL
                     GVHTPEDPFPVWRGEGGPAVVAPLFLLYDYTFRPAGKHTKKDALAYAYETGVVCTDEVL
                     LHPDPYATREDWCRARVAFTEERLDALDPELPTVLINHWPVVREPTRILHYPEFALWCG
                     TEATADWPVRYRAAAVVYGHLHIPRTIWHEGVPHVEVSVGYPREWQRERHPSPRLRQIL
                     PAPRPTGA"
ORIGIN
        1 aacgagcagt ggtagtcgtc gcagaccgtg aaggcgtcgg cgagcgcgta gtgaaagggg
       61 atgtcgtccc gtttcagata cgccatggtc cgctcggact tcgccgggat ccactggtcg
      121 tacgcgccgt tgttgaacgc cttgtggccg cccgcccagt cgtggtccag gcccgcgatg
      181 aactgcatgc ccaggttgtc ggcgtcaggg tggaagggca ggacctcctt gccgccgtcc
      241 tgctggtgcc agaccggctt gccgcttggc agggtcaccg gccgggggtc gccgaagccg
      301 cgtacgccct tcatcgtccc gaaatagtgg tcgaaggaac ggttctcctg catgagcacc
      361 acgacgtgct cgacgtccgc gatggtgccg gtgcggcgct tcgcgggcag cgaggccgcg
      421 cgggcgatgc tctcgttcag cgcggcgagg gcggcggtgc cgccggccag ttgcaggaag
      481 cggcgccggt tgagttcagg catggggata tgacctcgcg tgatgtgggg ggacgtgagc
      541 gggtgcagtg tgtcaactgg gccaaggctt atggaagagg caggcgggcc cgtgtccgcg
      601 agatgacgcc ggggccaacc gcgggtgccg ggaggcctgc gcgacggacg cgcccgcggt
      661 gccgtcaccg ccgcgcggac cgggcacgcg ttgcgggctc gtgaactctc ccccggcgag
      721 gaatgcggga gccgcccccg gccttgtccc cagtgatcgt cgacgtgcgc cacggggcgc
      781 gcgggacgca gcgaacggag cgagggacag atggccaagg cgtacgcgtt cacccggcac
      841 ggcggtcccg aggtggaggc cctgatcgac cgggagccgc ccgagccggg accggggcag
      901 ctgctggtca aggtgcgggc ggcgggcgtc aaccccgtcg accacaagct gcgcgggggc
      961 taccgcaggc cagggcaggc gcccgccgaa ctgcccgagg tgctcggcag cgaggcctcg
     1021 ggcgtggtgg agcggaccgg ccccggggtc gaggggttcg ccgtggggga cgcggtgttc
     1081 gggtccacgc tcaccggcgg gtacgccgag tacacgctgc ttccggtgac cgtcgccgct
     1141 cgcgtcccgg agggcctgtc cttcgtggag gccgcgacgc ttccggtcgc cgcggccacc
     1201 gcctacgacg gcgtgcgtca gctcgcgctg cccgccgggt cgacactgct cgtcaccggc
     1261 gccgggggcg gcgtgggcgg gaacgcggtg cgcctcgccc gccatctggg gctgcgcgtc
     1321 gtcggtacgg cgagcgacgc caagaaggac gtcgtcgagt ccctgggcgc ggtccatgtg
     1381 gcgccgggtc cggacctggt ggagcggatc cgtgccgccg ccccggacgg cgtcgacggc
     1441 gtcttcgacc tggtcggcgg ggaccatctg cgggccgtgg cggacgtggt ggccgaccgc
     1501 acgaagctga tcacggccgg cggcaagcag atcgtgacgg aactcggcgg ctccgccgtg
     1561 gcccgcgcgc gggacgccgc cacgctcgac gcggtggccg aactcgccgc ctcaggtgtg
     1621 ctccggccgc acatcacggc gacgtacccc ctggaccggg cgggcgaggc cctgcgcgcg
     1681 gtggagagcg gtcacgcact cggcaaggtc gtgatcgagg tcggcccatg aggtcgccgc
     1741 acgtgcccgg ttccggctgc gccgggacag ccgcagggcc ctgaccggaa acctgacaga
     1801 gaaactcggc agggaaactc ggcagggaaa cctgacaggg aaaaagaaaa agacggccgt
     1861 tcgttcggat tgataccttc cggaccatgc gtgcccttgg tgacaaagaa atccgtgcgt
     1921 cgttcgtgaa ctgctcgaag ggcgaggccc ggcgtctcac cctgcccgcg ggcttcgccg
     1981 agacgccctg gtccgacctg gacttcctgg gctggcgcga ccccaaggca ccggaccgcg
     2041 gctatgtcgt cgccgagcgg ggcgaggacc tcgtcggcat cgccctgcgt gcctccacgg
     2101 gggcccgccg ctccatgctg aagtccagca tctgttcggt gtgcgtgacg ccgcaggccg
     2161 gttcgggcat cgcgctgctc gtcgcgcccc gcgcgggcga ggcgggccgc cagggcaact
     2221 cggtcggtct gtacgtctgc gcggacctgg cctgctccct ctacgtgcgc ggcaagaaga
     2281 cgtcggccct ggcccgccgc ttcgacgaga gcctcacgcc cgaggagcag aacgaccgca
     2341 cggtccgcaa cctcaacggc ttcctggacc aggtgctcgc ccgcgcctag acctgccggg
     2401 ggtcgaccag ttgcagggtc agtgcgtccg gcgggtccgc gaggccgggg ccgcccgcct
     2461 cggcccaggt gaggatgtcg tcgagggacg cgtcgtccag ggcgaagccc acccaggccg
     2521 ggcggccgcc gtgcgcgcgg cccgtgcggg agggctggac gaccacgatg ttggcctggc
     2581 cgcaggggcc gaggcagtcg ctggtgcgca cggcgaaccg gccccccgac gcgtccgccg
     2641 ccgcctgcag ccgcgccaac tggcccacgt ggtcggtgcc ggggtgcttg accgggtcgc
     2701 cgcagcagca gccacggcag acgacgaggg tgcaggggcg cggggcgggc ggggtcgtcg
     2761 ggggcacggt gtcgggggcg gtgcggggat cgggcaggag cacggccggg gcggtgcggg
     2821 gctcgggcac ggtcatttca tgatcatgcc agggggcgct caggtcagat aggccaggcc
     2881 cgggtgtgcc tgccggtagc cgtcgaccag gcggcgggcc acggacaccg agtcgaccag
     2941 cgggtgcagc gcgaacgcct tgacggctgt ggcgcgcgaa ccgctgtccg ccgcggcgag
     3001 gacctcacgc tcgaccgcct tgaccgcgca caccaggccc gtggcgtgcc ccggcagcgg
     3061 tgacacggcc accgggtgcg gacccgacgc gtccactgtg cacggcactt cgatgaccgc
     3121 gtcggagtcc agctccggca gggtcgtgcg gttgcggacg ttgaggatca gcgtcgcgtg
     3181 ttcgtcgcgg gcgatggccc gcatcagggc gagggcgacc tgttcgtagc cgccggactc
     3241 catgtcctcg ggggcgcgtt caccggcgcc cgcggcctcc ctgctgtgcg ccatgtacgt
     3301 ggcctcccgc tcggcccggg tggcgtccca ggtcttgaac gcgggcgtcc cggggctccg
     3361 catctcctcg tagaagcggg cctgctgatc gcgcaggaac gcgccgcggg tccgctcggc
     3421 cgaccggtag gcgtggacgg tctcccggtt gaagtagtag tagtgcaggt actcgttggg
     3481 gatcacgccg agcgactgca gccagtcggc gccgaagagc ttgccctcct cgaaggactc
     3541 caggaggccg cggtcggcga gcagccgcgg cagcaggtcc tccccttcga cctccaggcc
     3601 gctcagccag cccaggtggt tcaggcccac gtagtcgagc cgtgcccggc ggggctcggc
     3661 gccgagcagt cccgcgatcc ggcggccgag gcccaccggc gagtcgcaga tgccgatgac
     3721 acggtcgccg atgtggcggg ccatcgcctc ggtcaccagg cccgccgggt tggtgaagtt
     3781 gatgacccag gcctcgggcg cgagccgccg cacccggcgg gcgatgtcga cggcgacggg
     3841 cagcgtccgc agcccgtacg cgatgccgcc cgcaccgacc gtctcctgcc cgagcacccc
     3901 ttcggcgagg gccacccgct cgtcggcggc gcgtccctcc aggccgccga cgcggatcgc
     3961 ggagaacacg aagtcggcgc cgcgcagcgc ctcgtcgagg tcggcggtga cgatcacggt
     4021 gggcgcgtcg gccacgccgg cggcctggtc ggcgaggacg cgggcgatcg ccgcggcccg
     4081 ggcaccctcc acgtcgtaca ggacgacctc ggtgacgcgg ccctcggcgc ggtcgccgag
     4141 cagcgcccgg tacacgaggg gcacacggaa tccgccgccg cccagaatcg ccagcctcat
     4201 gtctgaacca cctcgctcac agccccagtg aaggagaatc gttgaacatc gccccgaaca
     4261 cctaccactt cggacgatgc catgcggaac gcgaggtgac cgaaccgggg cccggaccgg
     4321 cgccgaactg aaccagcgcc gaaacgaacg ttctactcag tggcggccac agccgcgatc
     4381 gcccggcccg cccactccgg tgccgcctcc acgaactcgg cgaggcgctc acggatcgcg
     4441 tccgggaacg gcaccgcgcg gcccgccttc tggtcgacgt gcagcgcgag cagttccgtc
     4501 gtcgcgacgg gcgcggcgtc cggcgccgga tcggccgcgg caccgtcgac gacgtacagc
     4561 tcgtgggtga agtgcgcctt cttgccgtgc acgccgagga cccgggtgcg cacggcgagg
     4621 cgcgcgccct cggcgacgtc gcgcagatac cgaagatggg cctcgacggt gtagagggag
     4681 cagccggtgg cctcgcggta ggcggcgtcc aggccggtgg cgtccatcat cgcgtcggtg
     4741 gcgaacccga aggccagcga gtagtagccc tcgctcatat ggccgttgta gtcgatccac
     4801 tccggcggga cgacctgccg gtggaatgcg agacgccggg cgatctccct ggtcacatgg
     4861 ttcccttcgg ttcagcgtgg ccggcggcct ggcgcggcag cctccccgtc gcgcgcagta
     4921 cgtcgatgac gccctggtcg cgttcggcga cgaggtcggc gatggtgcgc ccggcggcgg
     4981 cctcgtcgca cccggcgacc accgcgtcgt acaggtcctt gtcgagctcg ggtgcttcga
     5041 gccgcgtcca cggggacttc agggaaggac cgaagtggtc gagcatatgg gccatgccgc
     5101 cctcgccgcc cgcgagcgcg aaggtgagca tggggcccat gaacgcccag cgcaggccgg
     5161 ggccctcggt gatggagtcg tcgatctcct ggacggtggc ctcgccgttg gcgaccatgt
     5221 gcagcgcctc gcgccacagg gcttcctgga ggcggttggc gatgaagccg ggcacctcgc
     5281 tcttcatggt gatgacggac ttgcccgcga cctcgtagaa gcgcgacgcc caggcgacgg
     5341 cctccgcggt ggtgcgctcg ccgccgacga cctcgacgag cgggatcagg tacggcgggt
     5401 tgaaggggtg cccgacgacg aggcggccgg ggtcggcggc cgtggtctgc atgtcggtca
     5461 tcggatagcc cgaggtggac gaggcgatga cgacgccggg cggcgcggcg gcgtcgagac
     5521 gcgtcaggag gtcgcgcttg agctccagct tctcgggggc gctctcctgc acgaactgcg
     5581 cgtcggcgac ggcctcttcg agggtcgcgg cgacggtgag ccgatcctgc gaggcgcctt
     5641 cggcgaggcc cagccgggtg agcgcgggcc aggcggcgtc gacgagtcgg cgcagccggg
     5701 cctcggcgtc gggggcgggg tcccaggcgg tgacgtcgta gccacgcgcg aggaagtgcg
     5761 cgacccagcc gccgccgatg acaccggccc cgacacaggc gacgcggcga acgtcttcgg
     5821 gggtggtcgt ggtcatggtg gaggggttcc tttcgctgct gggggtgccc ccgaaggggc
     5881 gcgggcgccc gcggtgcggg aggcggccta cacgcggggc ttgaggccca gcttcaggcg
     5941 ggcctcgtcc ggcgtggcga cccgagagcc aagactctcg gtgatctgga cggcccgctc
     6001 gaccagctgc gcgttgctca ccttgttccc cttgcccaga tacagattgt cctcgaggcc
     6061 gacccggacc tgcccgccga gcagaatgga ctgcgcgacc cacggcatct gcatgcgccc
     6121 gatcgcgaag ctggcccact gcgccccctc gggcagcatg ttgaccatcg actgaaggac
     6181 tccgggatcg gcgggggcac cccacgggat gcccatgcag agctggaaga cggtcggatc
     6241 gtcgagcagg ccctcggcca ggagctgctt ggcgaaccac agctgcccgg tgtcgaagat
     6301 ctccagctcg ggccgcacgc ccagctcctg gatgcgcctg gcgccctgcc ggagcatgtc
     6361 gggcgtggag acgtagaggt tggacccgtc gccgaagttg agggagccgc agtcgagggt
     6421 gcagatgtcg gggagcaggt cctcgacgtg cggaagccgg tcgagaccgc cgacgaggtc
     6481 ggtgccggga agctcgccga gccccttcag gggctgctcc gggtcgacca ccaggtcccc
     6541 gcccatgccc gccgtcaagt tgatgacgac gtcggtgccg gtctccttca cgcgttcgac
     6601 gacctcgcgg tagaggcggg ggtcacggga cggcgcgccg gtctcggggt cgcggacgtg
     6661 gatgtgcacg acggcggcgc ctgcctcggc ggcccgcacg gcgtcgcggg ctatctgctc
     6721 gggcgtgacg ggcacgtgcg ggctcttgcg gacggtgtcg cccgcgccgg tgagggcgca
     6781 ggtgatgatg acgtggtcgt tcacgggcat ggcggactcc ctttcgggtg ctgggggttg
     6841 tggtggtgct tcttcgggtg ctgggggttg tggtgatgct tcgggtgctg ggggtcgtgg
     6901 tggtgcttcg ggtgctgggg gtcgtggtgg tgcggagtgc gtacggggcc gcgtaccgaa
     6961 ggcgccgggg gtacgcggcc ggggctcagc gcgcggcgag cgcggcgtcc acgtgggcga
     7021 gcagggccgc gtgcatgtcg tcggggcggg tgccgggccc ttccggggtg ccggcgagga
     7081 cctgggcggc gaggccgtcg atgagggcgg tcaggtgcag ggcggccgct tcggggtcga
     7141 cggtcctgaa cgcgccctgg gcgacgccgc gccggacgac gtcggcgacg gtggcgcgcc
     7201 actgccggta gtactcggtg tgcaggcggc cgacggcggt ggagcgggcc gcctcggccc
     7261 acaggtcgag ccagacgctc cactggtcgc gctgctgggc ggtgcggggg gtctggagct
     7321 cgatgagctg gcgcagttcg tcggcggcgt cggccgcgtc ggcgatccgg gcggccctgc
     7381 gggcggtgtc ctcgtccatg caccagcgcg cggcggcctc caagaggtcg tcgcggccgg
     7441 ggaagtggta gtggatggcg gcggtgctgg tctcgcaggc cttggcgatg tcctggacgc
     7501 ggacggcgtg gaagccgtgg tcggcgatga ggcggacggt ctcgcggatg atctgcaacg
     7561 gccgcccttc ggggggcgtc gcggcgcgcc gtccgcgcgg gacggcgggg cgggccgcgg
     7621 ccgggcccgc gccgccgnnn nnnnnnncag ctccgccgcg gtgaagcgcc gggtgccgct
     7681 cagggagcgc gacagcttcg acgggtccat gacgatccgc cgcgcgaact cgcgctgggt
     7741 cacgcccgcc gcggcgatga cctcacggac acgggtgggg acgtcggggt cttgctccat
     7801 gccggccacc gtacccgcgc attgagatca gcacaacgcg agcttcatga ttctccggct
     7861 gcactcgctg ctttacgcca ttgcaatgct gactgatgca tcagtcagcg caatgcccct
     7921 ggcgccccgg gcgccccggg ccgcccctgg gccccgtccg cacccacccc cgccgcaccg
     7981 ccaccggcgc cgacaccacc ccgagcaccg ccacccaccc gcacacaccc gcccagccca
     8041 gcgtcgcgta cgcgagggca ccgagcgacg aacccgcagc gccgccgatg aaggcgcacg
     8101 tcatgtaggc cgtgttgagg cggctgcggg cctcgccgct gagggcgaag atccgcacct
     8161 ggttggcgac catcccggac tgcatggcca cgtccaggag cagcgtgccg agggccaggc
     8221 ccacgagccc tgccacgccg ccgaggccgc cgagggcgag gacgcccgcc gacgcgacga
     8281 ctgcgaccag gcagacggcg ttcaccgcgt ccgggccgcg ccggtcgatc tggcggcccg
     8341 cgaacggcgt cgccagcatc gtgcccgcgt tcaccagggc cagcgcgccg accgccgagg
     8401 cgccgaggcc gtacgtcccg ctcgtcagga agagggcgac ccccgtccac agcgcctgga
     8461 acgccgcgaa ggccgtcgcc tggtagaagc acgagagcct gagcaggggc tcggtgcgca
     8521 gcagtcgcag cgactcggcg agcagggccg gatagcgctg gctcgacgtc ggcacggtgc
     8581 ggggcagact gcgggcgagg acggccccga tgaggagcgc caccacggcc gtcacgaggt
     8641 agggcgcccg ccagccgagc cactcgccga gcgcgccgcc gaacgcccgc gagagcagca
     8701 tgccgccgat ggatccgctc aggagggtgc cggtgacggc gccccggcgc tcggcgggga
     8761 cgagtcccgc cgccatgggc gcgacgacgg gggccacgac cgttgtgacg ccgacgagca
     8821 cgctcgcgcc gagcagcggc ggcagcgcgg gcgcggcact cgcggcgagc agcccggcgc
     8881 cgctgagggc gaacagggtg gcgatgagcg tgcggtgcgg gacgcggtcg ccgagcggca
     8941 ccaggaagaa gatgccgagg gcgtagccga actgggccgc ggtcaccacg agggccgccg
     9001 tgtcaccgga cacgtcgagc ccggaggcga ccagcgggct gacggcctgc gggaagtaga
     9061 tgttgccgac ggcgacgcca caggccacgg ccaggaggag caccatgccg cggctgaggg
     9121 agtcgcgggg ggcgggggct tctggggcgg gggcttccgt agcggcggct tccagagcgg
     9181 gagctcccga agcgggagtt cccgtagcgg cggcttccag agcgggagtt cccgaagcgg
     9241 atgtctccga agccggagtt gccgatccgg cgcgggccaa ggcttccgga gcagcggcct
     9301 ccggggagca gggcgctgac gcggccggta tcggccccgg cgtgggcgtg gtgcgttcgg
     9361 tcacgaggga tcaccttcgc cgctgcggcc cccgcgcaca aggcatttct ccctctggcc
     9421 ccggcccagc cgcacccccg cccacctgcg cggcttgccc cttccccgcg cgtcaggggt
     9481 tagcttcgcg gccctctcca ccccaccacc gaggagccac cgtgacgccc acccctgact
     9541 cccctcactc ccccgggacc accggcaccc ctcgcacccc caccctcccc cgcgtctccc
     9601 gagaggtcag gctcgccgtc gcccccgacg ggctgcggca gcggctcgcg cgccggttgg
     9661 cggcgatccg cgcggcggcc ctcgcgcccg gggacgcacg cggcacacgg accgacgagg
     9721 agcacgcggc actaccgaag atgtcgaccc cggcaccgtc ggaggagtcg acccctgcac
     9781 ggccggagaa gcctgcccca gcgcggccgg acgcaccgtc gagacccccg gcacgacgcc
     9841 gctcccgcaa cacccgcccc cgcacgggtg tttgacccgg gggcgatttc ggcccggcgt
     9901 atcacgcgat ggtgtgaccg ggggcggcgc ccggcatccg acggcgcggc ccgggtagtg
     9961 ctcggctgcc cgtacgccgt ccgcgaggag agagccccgc atgccgcagc cgtcacgccc
    10021 cttcgaactg ccgagcttct acatggtcca tccggcgcgc ctcaaccccc atacggaaca
    10081 ggcgcgtgcg cacacccggg agtgggcgcg ggacatgggg atgctggagg gctccggggt
    10141 ctgggacacg gccgacctgg aggcgcacga ctacgcgctg ctgtgcgcgt acacccaccc
    10201 ggactgcgac agcgcggccc tgtccctggt cacggactgg tacgtgtggg tgttcttctt
    10261 cgacgaccac ttcctggagc tgttcaagcg cacccaggac cgggtgggcg gcaaggccta
    10321 cctcgaccgg ctgcccgcgt tcatgccgat ggacctcgcg acgccgatgc ccgagcccac
    10381 caacccggtg gaggcgggcc tcgccgacct gtggaagcgc acggtgccca gcatgtccct
    10441 ccagtggcgg gcccggttcg cggagagcac ccgcaacctc ctcaacgagt cgctgtggga
    10501 gctgtccaac atcaacgcgc accgcgtcgc gaaccccgtc gagtacatcg agatgcgccg
    10561 gaaggtcggc ggcgcgccct ggtcggcggg gctcgtggag tacgcgacgg gcgcggaggt
    10621 cccggcggcg gtcgccgcgt cccggccgct gcgggtcctc agggacacgt tctccgacgc
    10681 cgtacacctg cgcaacgacc tgttctccta ccagcgtgag gtcgaggagg agggcgagct
    10741 gagcaacggc gtcctggtcc tggagacctt cctcggctgc tccacgcagg aggccgcgga
    10801 cgccgtcaac gacctgctca cggcccggat gcagcagttc gaggagacga cgttcaccga
    10861 actcgccccg ctgtgcgccg agaaggcgct gacgccgcgg cagagcgccg acgtcctcgc
    10921 gtacgtcaag gggctccagg actggcagtc cggcggccac gagtggcaca tgcgctccag
    10981 ccggtacatg aacgagggcg ccgtcgaccg cccgtcgccc ctcgcgggcc ccaccggcgt
    11041 cggcacgtcc gccgccggca tcaaggccct catggccgcg accggcgccc agcgcgcgcg
    11101 ccgcttcacc cacgtcccgt accagcgcgt cggcccgtcc gtgatccccg acttcgacct
    11161 gccgtacacg accaccctca gcccccacct cgacgcctcg cggcgcgagg tcgtcgactg
    11221 ggcggcccgc atgggcatgc tggagcccca gccgggcgtg cccgcctcgc acatctggga
    11281 cgcccgcaag ctcgccgggt acgacttccc gctgtgcgcc gcgggcctgc acccggacgc
    11341 cacaccggag cagctggaca tcggctcgtg ctggctgacc tgggggacgt acggggacga
    11401 ctactacccg gtggtgttcg gcaggccccg ggacctgctc ggcgcgaagg tctgcaacga
    11461 ccgcctgctc ctgttcatgc cgctggactg ctcgccgacg cccccgcccg ccaacgccct
    11521 ggagcggggc ctcgccgacc tgtgggcgcg cacggccggt ccgatggacg ccgggggccg
    11581 cgccctgctc caccgcaccc tggtggacat gacggacagc tggctgtggg agctggccaa
    11641 ccaggcccag aaccgcatcc cggagccggt cgactacatg gagatgcgcc gccacacctt
    11701 cggcgcgcac ttcacgatga gcctgagccg cttcgggcac ggcaagcggg taccgcagga
    11761 gatctacgcg agcggaccca tgcagaacct ggagaacgcc gccgccgact actcgatgct
    11821 catgaacgac gtcttctcgt accagaagga gatcgagtac gagggcgagg tgcacaacgc
    11881 catcctcgtc gtgcagaact tcttcgactg cgactacccg gcggcgctcg gcatcgtcga
    11941 cgacctcatg cggtcccgca tgagccagtt ccagcacgtc gtcgcgcatg aactgcccgt
    12001 cctgtacgac gagttcgacc tggaccagga ggtgcgggac atcctcgacg gctatgtgca
    12061 ggagctcaag aactggatgg ccggaatctt cgtctggcac cgcgactgcc gccgctaccg
    12121 ccaggaggac ctctcgcacg ggccgctgcc cgagccgtcg gggctcggca tggaggtggt
    12181 gcggcccggc tggctgcggg agctggcggc accctgagcc gtgcgggcgg gggcgggtaa
    12241 ggtcggcggt cgggccgatc accggggtcg gcccggggcc ggcgcggtcc ggccccggga
    12301 acatggggag ggcgcgcgcc gtgcgggagc cgaaccacgt ccacccggcc acccccggag
    12361 cccccgcccg ctggctcacc gtcgcgcccg aacgcaccgt gctcggcgtc atccacaacg
    12421 tgacctcggc gacccggctg ctcgacctgc tcaccgtctt cgacggcgac cgaagggtgc
    12481 agaccgtgtt cacctgcacc ggctcctccc cgttcgcgga cggcgtcgcg gagttcgccg
    12541 ccgcccgcga actccccttc cccccctggg acgaggcggt gaaggcggag ttcgacctgg
    12601 cggtcggcac cagccgcggc ggagccctgc acagaatctc cgcaccactc atgggcgccc
    12661 cgcacggcgc gggatacaat aaaagactca gcagccggga gccgggagcc gggagccggg
    12721 agccgggagc cgggagccgg gagccgggag ccgggagccg ggagccttcg gcctgacggc
    12781 tgaatggctc gtgtacgacg gcgagttgat accgtccgcg atcgtcctct cccacgagga
    12841 acagctcgcc cggctgcgcg tcggctgccc cgaggccctg ccggtggcgc acgtcgtcgg
    12901 cgacccctgc atggaccgcc tccgcgcctc cctccccttc cgcgccgagt accgcgccgc
    12961 gctcggcgtc cgccccgacc agcacctgct cgtcctcagc tcgacctggg gccgcggctc
    13021 cctcctcggc gccgcgggcg acctggtgct ccgcgcgctc gcggaactcc cccacgactc
    13081 cttccgcgtc ctcgccgccg tccaccccaa cgcctggtac gggcacgggg gttggcagct
    13141 ccgctcgtgg ctgcggcccc acctggacgc cgggctgctg ctcccgccgc ccgcggacga
    13201 cacctggcag gcggcgctgt gcgcggcgga cgcgttcgtc ggcgaccacg gctcggtgac
    13261 gctgtacgcg gcggggctcg gcctgcccgg actgctcggc gcgttcgacg aggacagcgt
    13321 ggccgcggac tcccccatgg cggccctcgg cgaggcgctg ccccgcgtct cgcccgcgcg
    13381 acccctcgcc gcccaactgg agcgcgccgc ccgcgatcag ccgacggacc cccggctcgc
    13441 cgccgtcacc tcgcagatca cctcccaccc gggcgaggcc ccggcccgcc tgcgccgcct
    13501 ctgctaccgc atgctcgacc tggacgagcc cgcggccccg ctcgcgccgc gccccgtcga
    13561 cgtaccgcgg gacctgccgt cggcaccccg cccacccgtg gaacggccgc tgttcgtcga
    13621 ggccttggtg acgtccggcg acggcgacga cgcgaccacg ggcccacacc cgcccctgga
    13681 gcccgccggg ccgaccgagg tcctgatccg gcgccacccc gcccacgtcc gggccgccgc
    13741 caccccgcac ccgccgctca ccgacgccca cctctccgtc accgcgggcg aacccgacgc
    13801 ccgttgggcg cacgcagcgg acgtggtcac ggcccgagca cccgcgtccg gaccccatct
    13861 tgccgcgctc accgatgagt tgttcgctgc ccacccgggc tgtgtgctgg tcgccgtgga
    13921 gcaagaggac ggccggtgct tgctgcgcac ccgcaacggc gcttcctttc acggctgttg
    13981 ggagtctccg cccgcctggg ccacgacatc tctcaccgct tcggcggtgt acgcctggct
    14041 gctccggcac ggggagagcc tggcgggcga ggtgctggtg cggctcacgc cggacggcgt
    14101 accggcgcgt ctgcgcgtgt ggcgcctcgg cacgaactct gctctgcaca gcgccagttg
    14161 acgctcacga gtcgccgccc tcgcccagtc gctcccgcgc ccccgccgcc gccacgctcc
    14221 ccaacgtccg gtacgtgtcg agcgccgccc gccagtcctc ccgcgcccgc gtctcgtcgc
    14281 cgcgcaccgc ccacgcgtcg ccccgggcga ggcgggcgtc ggcctcctcc ttgggggcgc
    14341 cgcgctcccg caggagggtg atcgcctcgt ccagcggggc gacggcctcg tcggcgcggt
    14401 cggcggccag gcgggcctgg gcataacggg tcagcgcgcg ggcctcgttg tagcggtcgg
    14461 gcacaggcag ctcggcgaag aggcggcggg cgccgaggag ggcctcggcg gcctcctcgt
    14521 ggaggcgtgc ggcgctcgcc gcgcgcccca tgtggtactg gagcaacgcc cggccgcgcg
    14581 ggtgcgccag gtctccgagc gcgcgcagcg cctgccggaa gcagtcgagg gcgtcctgcg
    14641 ggcggccctg ctccaccgcg acctgaccga ggccttcgag cgcggaggac tcggtgcggg
    14701 cgtgcccggc cgcgcgggcc tggctcaggg cgagcccgta gtggtgcccg gcccgctcca
    14761 cgctgtgcgc gccgccctgg tcgaagaggg cgaacgccag ctcgtagtgg cagcgggcca
    14821 ggacgaggga ggcgtcgtcg ggcgtttcgg caaccccggc ggcaccggcg tcttcggcgc
    14881 ccccggcggc cgggcccggc cccgcccccg ccgcatccgc cgcatccgca gcccgagcct
    14941 ccaccatccg ctcggccgcc cgcacccccc gctcggccac ctccacccac aacgtgtggt
    15001 gcttccgccg gaagaagaag cctcgcagcg cctccgccag gtcgcacacg aggaggtcat
    15061 ggccgcgcgt gaactccagg ccggtgaggg cggcggcgtt ctcgcggtcc gcttcgaggg
    15121 cgtccagggc ctcggcctcg ctgccgaaca cgccgtccag gacggtgggg tcacggaaga
    15181 tcgcggcgcg gcgccagcgg ccggacacca ggcgctcggc cgccgcggcc cgccgcaggt
    15241 accagtcggt gatgcgggcc gcgaccgccg cggcctcggc ggcgtccgtg cgggcgaggg
    15301 cggccgcgta ctcgtggagg aggccgttca tgcggcagcg gccgggcgcg ggccgttcga
    15361 ggaggttgcc gttgaggagc gtgcgccgcg cccgcgcgcc cgcttcgggg ccgcccgcca
    15421 acgcgtcgac gagggcatcg gcgaactcgg gcgtcgggtt caggccgagc ccgcggaaca
    15481 cggcggccgt cgcgggttcg agcgcggcgt aggagtcctc gaagacggac cgcagggagt
    15541 acgtgtgcgg gtcgtcgggc acggtcagcg cctcctggaa ggtgggcagg gccaggagcc
    15601 tgcggacgaa ctcctcgaca ccgccctcca gcgggtccgc ggcgcgcgcc ccggcgagcc
    15661 gggcggcagc gggcaggccc gcgaaggcgg ggatgacggt ccggagtaac tcctgtcccc
    15721 ggtccgtgag ttcggcggcc gtctcacggc ccgccgtgtc gaggaacagt tcccggcagg
    15781 actcgtcgtc gagcccggcg aggcggacgt acacgggttc ggagcccggc aggacggggc
    15841 gcaggccgtt caggagcaga cggctggtga tcacgaccat gctctttggg tgcccgggaa
    15901 gcagcggcgg gacctgaccg gccgtcacga cgtcgtcgag gagcaccagg cagggttcgt
    15961 gcgcggtgag gtggcggtag tacgcggcga gcggcgccgg gtcggcgggc atctcggcgc
    16021 gcggggtgcc gagcgcggcg acgaacgact ccaggacgga gcgggtgtcg gccggttcca
    16081 gggcgccgcg cgggctcatg tcggcgtaga ggacaccgcc ggggaagtcc ccgcggcgcc
    16141 gcgccgacca gtgcaggacg gcgccgctct tgccgatgcc cggcggcccc gtcaccacgg
    16201 cgacctcggc ggcggcgcgc acgggccggg cgtcggcggc gcggtcgagg gcggcgcgca
    16261 ccggaaggcg gtcgacgagc cgtccgggcg cggcgggtgc catgaacggc acgcgcgggg
    16321 cccgcacttc accgctcacg cactgccgca cggtgacgtg acccgcctgg atgacgtcgc
    16381 ggaaggtccc gcccgagatg ttgttggcca ccgaatccac ccgggcagtc ttccagggcg
    16441 ccgcgcctga cggaacgcca cctcgcgcac cggtccgagc aggggaccgg tgcgtctcag
    16501 tggtgcccgt ccccgctgtg gatccgccgg tactcctccg ccgtggcctt cggcacctgc
    16561 gcgccggggc cgtacatcgc gcgggagagc cgcgcccgca gccgctccga gcggggcacc
    16621 ttgcgggcca cgccgtttgc gtcgaccagc gggcccacct cgtggggctg gggctgttcg
    16681 tgggcggtga gccggtagcg ctcggcctgg ctgaggggtt cgtggacctc gacgtactcg
    16741 ccgtgcggga ggcgtttgat gatgccgctc tcgcgcccgt gcaggacctt gtcgcggtcg
    16801 cggcgctgca gacccagaca gatccggtgg gtgacgacga aggcgagcgg cggggcgacg
    16861 aagaaggcga cgcgcacgaa ccaagtgatg gcgttgatgg agaggtggaa gtgcgtggcc
    16921 cacaggtcgt tgccgccgcc gaccatcagg acgccgtaca gcgtcagcca ggccacgccg
    16981 aggcccgtgc ggacgggcgc gttgcgcggc cggtcggcga tgtggtgctc gcgtctgtcc
    17041 ttggtgaccc aggactcgat gaacggatac gccccgatcg ccgccatgat cagcgggaac
    17101 agcgcgaagg ggatgaagac ccccagctgc agagtgtggc cccaggcgtt gatctcccag
    17161 ctgggcatca cccggatcag gccctcggag aagccgaggt accagtcggg ttgtgcgccg
    17221 gtgccgacga ggtcggggcg gtagggcccg agcgcccaca cggggttgat ggtggcgacg
    17281 gcgcccatca tggcgaggac gccgaagacg aggaagaaga agccgcccgc cttggcgatg
    17341 tagatgggca ggaagggcgc gccgaccacg ttcttctcgg tccgtccggg accggcgaac
    17401 tgcgtgtgct tgtggtagaa gaccaggatc agatgggcca cgaccaggcc cagcatgatg
    17461 cccggcagca gcaggacgtg cacggcgaag agtctcggga tgatgtcgtg gcccgggaac
    17521 tcccctccga agaggaagaa ggagaggtac gtgccgatga ccgggatcga caggatggcg
    17581 ccctgcgcga agcggatgcc ggtgccggac agcaggtcgt cggggagcga gtagccggtg
    17641 agtccggtga tgaggccgag catcaacagg gtccagccga acacccagtt gagctcgcgc
    17701 ggcttgcgga acgcgccggt gaagaacacc cgcatcatgt gcacgagcat cccggcgacg
    17761 aacacgagcg ccgcccagtg gtggatctgc cggatcagca gaccgccgcg cacctccatg
    17821 ctgatgtcga cggtcgactc gtaggcgcgc gtcatcacga cgcccttgag cggttcgtaa
    17881 ctgccgttgt actcgacctc caggccgctc ggctcgaaga acagggtgag ccagacgccg
    17941 gtgaggatga ggatcaggaa gctgtagagg cagatctcgc cgaacatgaa ggaccagtgg
    18001 tccgggaaca ccttgcgcat ctgggtcttg gcgagggtgt gcacgccgag gcggccgtcc
    18061 gcccagtcgg cgacgcgttc acccttgccg ggaccggggt cgcgtgtgcc ggggccggtg
    18121 ttgcgggcgc gttcgctcat gcggctcccc ccctcgggcg gctaccaggg taggtgcgcc
    18181 acgcgccccg gcaacagggt cgtgcggtcc gcggggaaga gggccacctc ggcccccgtg
    18241 cgcctcacca ctcggcgaag gagccgtccg ggtgccgcca cacggggttg cgccaggcgt
    18301 gcccgctccg gtcggccgcc cgcaccgcgg cctcgtcgac ctcgacgccg agcccgggca
    18361 gggccgtgcg gtgggcgtac ccgtcggtga agcggaacgg ctcggtgtcc acgacgtacg
    18421 acaggaggtc ggcgctcttg ttgtagtgga tgccgcggct ctgctcctgg atgaggaagt
    18481 tcggagtggt gaaggcgagt tggaggctcg cggcgagcgc gatcgggccg agcgggcagt
    18541 gcggggcgag gagcgcgccg tgggtctccg cgagcgcggc gatgcgctgg acctccgtga
    18601 tgccgcccgc gtgcgacagg tcgggctggg cgacggcgat gcccgcggtg agggcgggca
    18661 ggaactcggc gcggctgtag aggcgttcgc cggtggcgat cgggacgggg ccggccgcga
    18721 ccagggcggg cagcaggtgg cccaggtcgg gcgggagcgg ttcctcggcg aacagcgggt
    18781 gcagcggggc gagttcggcg aggacgcggc gggcgctggc gggggtgaag cggccgtgga
    18841 agtcgacggc gacgtcccgg tcggggccga gagcctcgcg ggcgatggcg acgcggtcga
    18901 ccacggcggc ggtctcggcg ggcgtggtga gcggtgacgt cgccccggcc gcgttcatct
    18961 tcacggcggt gaagcccgcc tcgacctgct cggcgatgtg ctcggcgagc acggcgggct
    19021 cgtcgccgcc gacccacgcg tacacccgcg cccggtcccg tacgggcccg ccgagcaggg
    19081 cgtgcacggg cgcgccgtac gtcttgcccg cgatgtccca cagggcctgg tcgatgcccg
    19141 cgacggcgct ggagaggacg ggtccgccgc ggtagaagcc gcccttggtg aggacctgcc
    19201 agtggtcctg gatccgcagc gggtccttcc cgacgaggta ctcggcgagt acgtccacgg
    19261 cggcgcgcac cacttcggcg cgcccctcga cgacgggttc gccccagccg accacgccgg
    19321 tgtcggtctc cacgcggcag aacagccagc ggggcgggac gaggaaggtc tccacgcggt
    19381 cgatcttcat ggtgtgtccg tctctcctcg ctcggggcgg tgtgcggtat gcggtggggt
    19441 gcgcagcggt tcgggaccga gcgcatcggg accgggcgga ccgggtgcgc ggcggtgggg
    19501 ccccctcagg cggagtcctt caccacgctc cagccgccgt ccacggtcag gctcgtcccc
    19561 gtgatgtacg acgcctcgtc ggcggcgagg aacgcgatgg ccgccgcgac ctcctccggc
    19621 gccccgaacc tcccggccgc cgtcccctcg acgctgcgcg cccggtcgtc ctcgcccacg
    19681 ttcccccacg cgggcgtcag gatcggcccc ggcaggacgg cgttgacccg cacctcgggc
    19741 ccgtactcga cggcgagctg cccgcacagg gagaccaggg cgcccttgct cgccgcgtag
    19801 gcggggcggc ccgggatgcc ggtgcgggcg tgcacggagg aggtgagaac gacggcgccg
    19861 cggtgggcgc gcaggtcggg caggacggcc ttgacgccga ggaacgtgcc ggtgaggttc
    19921 accgcgagct ggtgctccca ggaggcctgg gtcatggcgt gggcgggggc gacctcgcag
    19981 gcgtaggcgt tgctggagag cacgccgacg gggccgaagc tgtgcgcggc cgcgaggacc
    20041 tggtcccagt cggcggcgtc ggcgacgtcc gcgcggacga acaccgcgct gccgcccccg
    20101 gcccggatgc cctccgcgac cggctcgccg tggtccgcgt ccacgtcgga cacgacgacg
    20161 gccgcgccct cggcggcgag gcggacggcg gtggcggccc cgatgccgga ggcgccgccg
    20221 gtgaccacgg cgaccttgcc ggtgaagcgg gatgcgggtg cgcttgggtt cacgtgcggc
    20281 gtcccctcgt acgggtgggc ggcgaccgct gatggcatgc gccgtccact ctatgtccgg
    20341 tgccggctcc ggacacctgc cgactcagcg gccacgccgt actccgcggt ctcccggggt
    20401 gccccggaca ccgcggatgc ctcagatgcc gcagaggctg tgcaggctgt ggaggccgcg
    20461 ctgtcctgcc gtggggcccg ggcgtcaggc cccggtgggg cgcggtgcgg gcaggatctg
    20521 ccgcagtcgc ggcgaggggt gccgctcgcg ctgccactcg cgcggatagc cgacggagac
    20581 ctccacgtgc ggaacgccct cgtgccagat ggtgcgcggg atgtgcagat ggccgtagac
    20641 gacggccgcg gcgcggtaac gcacgggcca gtcggcggtc gcctcggtgc cgcaccacag
    20701 ggcgaactcg gggtagtgca ggatgcgcgt gggctcccgg acgaccggcc agtggttgat
    20761 gaggacggtc ggcagctcgg ggtcgagggc gtcgagccgt tcctcggtga aggcgacgcg
    20821 ggcgcggcac cagtcctcgc gggtggcgta cgggtccggg tgcaggagca cctcgtccgt
    20881 gcagaccacg ccggtctcgt acgcgtacgc gagggcgtcc ttcttggtgt gcttgcccgc
    20941 gggccggaac gtgtagtcgt acagcaggaa cagcggggcg acgaccgcgg gaccgccctc
    21001 gccgcgccag accgggaacg ggtcctcggg ggtgtgcacg ccgaggctcc ggcacagctc
    21061 cacgaggtgg cggtagcggg cctcgccgcg cagttggttc gggtcgtcgc ggggcgtcca
    21121 cagctcgtgg ttgccgggcg accagatcac cgtgtcgaaa cgctcggtga gggtgcgcag
    21181 cgcccactcg atgtcgctca tcatctcgcc gatgtcaccg gcgactatca gccagtcgcc
    21241 ctcgtgttcc ggccagagct cgtcgacgaa cttccggttc tcggcatagg cgatgtgcag
    21301 gtcactgatg ccgaacagcc tcggcgcccg tcgggatgcg gcagatgtcg tcaccacgtg
    21361 aggctaaccg acgtgcgctg tcgcgccgca gtcgcgcccc gggtgctcca cgcgacctcg
    21421 gtgcgccctc ggcgaccaag gtctaaggtg cccagaaggc ggttctggtc acggacgggg
    21481 gcttgagtgg acgccggcac ggtggggctt cggatcgcgt cgtcggtgat ggtgccgctg
    21541 gtgaagcggt tgctgctgcc gcccaagaga ctgccggggg ccgagttcgg cgagcggccg
    21601 gtgcgcatcg ggcggctcct gtcgttcacc ggtgacaagc gcgtcctcag cgatgccgat
    21661 ctctaccagc tcgcccggga gttggtgcgc cgcgcgatgc gcgccgcggg cccccacgac
    21721 ccgcccatcg ccctcgacga gcagaacgcc gtcggctacg ccctcggtca caccctgcgc
    21781 gccctcggcg aactcgacat ggacgacgta caggcctacg acctcggccc ggagaagctc
    21841 gccgccgccc tggtccgcgc cagcgccccg gagacccgcg cgctgctcag cgccgacgcc
    21901 gcccgcctgc acgaccggct gctcgtcacc gcctgtctgc atctggtcca tcagttcagc
    21961 acgcgccccg gcttcgaggc ccgcacccag gtcgagacgc gccgcagcct gagcgagcag
    22021 aaggagcaac tgcggctgct cctggagcgg ctgcccacga ccctcgccga ggacaccgac
    22081 ttcgagcagg cctacgccga ctatgtggtg acccagcaca gcagcctcac catccacggc
    22141 gtcgacctgc acgacccgca gagccaggcc tggccgctgg agaccgccta cttgagcctg
    22201 gaggccgcgc ccgcccg
//
