LOCUS       NZ_RHGC01000005        10402 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig005, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000005
VERSION     NZ_RHGC01000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 837086)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 837086)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 375578
            Orig. end                         :: 385980
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10402
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="melanin"
                     /region_number="2"
                     /rules="melC"
                     /tool="antismash"
     cand_cluster    1..10402
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="melC"
                     /kind="single"
                     /product="melanin"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10402
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:5402](+)"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5402
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="melC"
                     /neighbourhood="5000"
                     /product="melanin"
                     /protocluster_number="1"
     gene            complement(79..1194)
                     /locus_tag="EJ355_RS21840"
     CDS             complement(79..1194)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010046798.1"
                     /locus_tag="EJ355_RS21840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF3344 domain-containing protein"
                     /protein_id="WP_193560724.1"
                     /transl_table=11
                     /translation="MRHLLRPRRVLAVLLALTGCLSLTGTGSAAPGTDTAAPAGEKPRI
                     AFAQRYHAVQHGGIVRAANSAITCRRPVSRAAAPCADVRRGGPGANHDFEMFYTDIDRD
                     PNTYNSSAGEVRLPAGSRVSYARLYWGGNLRVGEQKPPKDNGRVLIAEPGGSYRAVLAD
                     TLTGHRVAGGADAFQASADVTSLVRSSGSGLYTVAQVNVAMGHSKAGAWGGWTLVVAYE
                     NAALPKRSLALWDGFDSFGVPGRRHTVRMKGVPVAPGAAGGGGVVGLVAYDGDRGVRGD
                     AVHVSAGRGRPVPLSDRANPADDVLNSTVSEPGRPARRSPAYANTLGYDSDVLRLPDRL
                     RGQRGDLTVRMSARRDAAWTGVLFAAVDMKR"
     misc_feature    1229..1243
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     gene            1479..1718
                     /locus_tag="EJ355_RS21845"
     CDS             1479..1718
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019056482.1"
                     /locus_tag="EJ355_RS21845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_087887727.1"
                     /transl_table=11
                     /translation="MSRTSKALALSAVAAAAVAGGAGVAAADSGAQGAATHSPGVVSGN
                     AIQVPVHVPVNVCGNSINVIGLLNPAFGNTCVND"
     gene            2016..2669
                     /locus_tag="EJ355_RS21850"
     CDS             2016..2669
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015660307.1"
                     /locus_tag="EJ355_RS21850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_125263605.1"
                     /transl_table=11
                     /translation="MRALPVRRTATTFLCTALLLGTAGPVYAATHDDTAREAVAAAPQA
                     PVPGADALLAQVKTLGDIGGVLKPVTDLLDTALKADNGQLPAADAAKLGDAVKAAIAAV
                     TAAAPKGAELPATPQLPATPQLPLGGAPAAQAPMDLKGDALAALQKAVDTLLKAVTGGD
                     PTAVLPAATAVVTGLVNVVVATVLGGGLPVPNLPGLPALPKLPTDALPLPKLPV"
     misc_feature    complement(2759..2772)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     gene            2930..3208
                     /locus_tag="EJ355_RS21855"
     CDS             2930..3208
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644659.1"
                     /locus_tag="EJ355_RS21855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_030360551.1"
                     /transl_table=11
                     /translation="MKSLKAAAVLAGSMAVAGVAAPAMASDLTPTSLNGGLETVLGQSM
                     LDTKPVSTNMLDTENKDSVVNTVTDAAESVNQGGGPAKLLGGLPLQK"
     gene            3336..3584
                     /locus_tag="EJ355_RS21860"
     CDS             3336..3584
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019060703.1"
                     /locus_tag="EJ355_RS21860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_087887728.1"
                     /transl_table=11
                     /translation="MKNVKKAALVIAAAGLAAGAASGSAFASGDGASAEGAAVGSPGVG
                     SGNLAQVPVHVPVNVVGNTANLIGALNPAFGNSGTND"
     gene            3789..4292
                     /locus_tag="EJ355_RS21865"
     CDS             3789..4292
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065676.1"
                     /locus_tag="EJ355_RS21865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF5949 family protein"
                     /protein_id="WP_030360553.1"
                     /transl_table=11
                     /translation="MTSTSNEQRTFRVTDLGTLAVLAWSGEHPEDEQDMAFLLAYSLGD
                     AEGGPEATAEAMRTLLRNEQLPLGGPVLDGARTPSLPVSLLVEAEQAVVNMPHVKAQCV
                     VPPEWLAAVEQRGHAYFMITTVAWPEGKPGSPVSEEALRDFAGSEDTMLNAAHCLLPVR
                     RLRA"
     gene            4292..4954
                     /locus_tag="EJ355_RS21870"
     CDS             4292..4954
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016644657.1"
                     /locus_tag="EJ355_RS21870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="vitamin K epoxide reductase family protein"
                     /protein_id="WP_087884976.1"
                     /transl_table=11
                     /translation="MRTVATTGRVPAQVSGARPATAPRPDDSRTAGGGRGLALLLVLTA
                     AAGLLASWVITLDKLRLLKDPDYVPGCSMNPVVSCGSIMKSEQAAVFGFPNPLLGLAAY
                     AVVLCVGASLLAGARLPRWYWLTFNAGTLFGVGFCTWLQFQSFYRVNALCLWCCLAWAA
                     TILMFWYVTSHNVRHGLLPAPAWLRTFMNDFTWVLPVLHAGVIGMLILTRWWDFWMS"
     gene            5001..5402
                     /locus_tag="EJ355_RS21875"
     CDS             5001..5402
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013003508.1"
                     /locus_tag="EJ355_RS21875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase cofactor"
                     /protein_id="WP_051811051.1"
                     /sec_met_domain="melC (E-value: 4.9e-44, bitscore: 145.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVSRVSGANRLKRRHLIAVAAAAALGAVGAFRGLREKDEREGL
                     PGAPGGPGFDETYRGRRIQGEPTTGEREHGPDGWRVTVDGQPLGLMRRADGSYLSMVDH
                     YQSYATPLAAARGAVDELGSYQTLSGRLH"
     gene            5446..6315
                     /locus_tag="EJ355_RS21880"
     CDS             5446..6315
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889041.1"
                     /locus_tag="EJ355_RS21880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tyrosinase family protein"
                     /protein_id="WP_087884977.1"
                     /transl_table=11
                     /translation="MAYTRKNQNSLSRAERRRFVDAVLRLKRRGEYDEFVRTHIDFYVS
                     DGDDRLRVAHMTPTFLPWHRRFLLDFERALRRIDDSVTVPYWDWTKDRSPAASLWGEDL
                     MGGNGRRSDRRVMTGPFARGNGWVVKEAVTDGDFLTRDLGRRADPLELPTRQDVAWAMA
                     ETVYDVEPWDSTSRRGFRNRLEGWTEESGSARWRNHNRVHRWVGGHMLGGASVNDPVFW
                     LNHAFVDLLWSRWQRKRPDSAPFLPAKPPTLGDAQYQRIVARREPMPPWRTTPQDMLSH
                     KSVYRYAE"
     gene            complement(6401..6667)
                     /locus_tag="EJ355_RS21885"
     CDS             complement(6401..6667)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007818707.1"
                     /locus_tag="EJ355_RS21885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chaplin"
                     /protein_id="WP_087884978.1"
                     /transl_table=11
                     /translation="MSRIAKAAAVTLGAGAVVLSGAALASADAGAQGKAVGSPGVLSGN
                     LIQVPVNVPVNVCGNTVDVIGLLNPAFGNQCANKGELHGGYGK"
     gene            6908..7168
                     /locus_tag="EJ355_RS21890"
     CDS             6908..7168
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010354507.1"
                     /locus_tag="EJ355_RS21890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_237307371.1"
                     /transl_table=11
                     /translation="MAAVSLAAGAAALAAPAAHASTDASTASKISVLDTIDELQTSSIP
                     AERRAEVPKVADQLGGLHQLHQLHQLTDLVAPVTNAVPAVQ"
     gene            complement(7198..7893)
                     /locus_tag="EJ355_RS21895"
     CDS             complement(7198..7893)
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007384111.1"
                     /locus_tag="EJ355_RS21895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M23 family metallopeptidase"
                     /protein_id="WP_087884980.1"
                     /transl_table=11
                     /translation="MGYDIDGPREAGTTRRDALGLAAGLLAGGALAVTTAPPASADDDE
                     WTAPGELWVPDAEDWCVADFDAEFEADLAAAEALLPEEDSRGLGAAAAPKGRYTRPLRR
                     RYRVTSRYGVRGNWAAGHHTGIDLGVPRGTPVYAVTSGVVVLARWSGAYGKAVTVRMPD
                     KRYVLFAHLSRISVRQGQRIRTGARIGYSGATGRATGPHLHLEIRARRGYGSDINPVSY
                     LARRGVRLL"
     gene            8136..8768
                     /locus_tag="EJ355_RS21900"
     CDS             8136..8768
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016642290.1"
                     /locus_tag="EJ355_RS21900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="chemotaxis protein CheB"
                     /protein_id="WP_237307372.1"
                     /transl_table=11
                     /translation="MTAHQRVERAADAYTQHAEASYSAVAIAASAGGVHGVAVLLGALG
                     PELSVPVLLVQHLDPRHRTVIAEVLGRRTPLPVKLAEHDERALPGTVYIAPPDRHLLVG
                     ADGVLTLSSSARVHFVRPSADLLFESVAGAYGHRAIACVLTGTGRDGAMGVDAVKSRGG
                     TVIAQDPRTAEFSGMPEAAVGTGAVDFVLPLEEIAAIIRGLVEGKRQ"
     misc_feature    9138..9152
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
ORIGIN
        1 gcggcgcggg ggaggagttc gacggcagtt gcatgcacga ctccttgagt tcctagggtc
       61 aggacgacgg aatacgcgct accgcttcat gtcgacggcg gcgaagagca cacccgtcca
      121 ggccgcgtcc cgccgcgcgg acatccgcac cgtcaagtcg ccgcgctgtc cgcgcagccg
      181 gtcgggcagg cgcagcacgt cggagtcgta gcccagagtg ttggcgtacg ccgggctcct
      241 gcgggccggc ctgccgggct cgctgacggt cgagttcagt acgtcgtcgg cggggttggc
      301 gcggtccgag agcggcacgg gcctgccgcg ccccgcggac acgtgcaccg cgtccccgcg
      361 cacgccccgg tcgccgtcgt acgcgacgag cccgacgacc ccgccgccgc ccgccgcgcc
      421 gggcgcgacg ggaacgccct tcatccgcac cgtgtgccgc cgccccggta cgccgaacga
      481 gtcgaacccg tcccacagcg cgagcgaccg cttcggcagc gccgcgttct cgtacgccac
      541 gaccagcgtc cagccgcccc acgcccccgc cttggagtgc cccatcgcca cattgacctg
      601 cgcgactgtg tagagccccg agccggagct ccggaccagc gaggtgacgt cggcggacgc
      661 ctggaacgcg tccgcgccgc ccgcgacccg gtggccggtc agggtgtcgg cgaggacggc
      721 gcggtagctg ccgccgggct cggcgatcag cacccggccg ttgtccttgg gcggcttctg
      781 ctcgccgacg cggaggttgc cgccccagta gaggcgggcg tacgagaccc gggacccggc
      841 gggcagccgg acctcgcccg cgctggagtt gtacgtgttc gggtcgcggt cgatgtccgt
      901 gtagaacatc tcgaagtcgt ggttcgcgcc gggtccgccg cgccgcacgt ccgcgcacgg
      961 ggccgccgcg cgggacaccg gacggcggca ggtgatcgcc gagttggcgg ctcggacgat
     1021 cccgccgtgc tggaccgcgt ggtagcgctg tgcgaaggcg atgcggggct tctcgcccgc
     1081 gggggcggcg gtgtccgtgc ccggggccgc gctgccggtg ccggtcagcg agaggcaccc
     1141 ggtgagggcg agcaggacgg cgagcacacg acgcgggcgc agaagatgac gcatgacggc
     1201 actggccttc cacggtgcgg ttaatcgcat taaatgtgtg gatctgagcg cgtatgacgg
     1261 aaatagactc agaaggaagc gcaacagtag cgtttattgc gggagtttct gatgacttgg
     1321 tggcgtgtgt cggattggtg aagcgtgtgg ccgaaccgcg aggaagacat cactcatctg
     1381 ggcgcacaac cgactgtcgg ggaactcagt tgatccccac accgggcatc acgcacggct
     1441 tgaagcatca ccagcatcag aacaaggagc agtactccat gtcgcgtacc agcaaggccc
     1501 tcgccctgtc cgccgtcgcc gccgcagccg tcgcgggtgg cgccggtgtc gccgccgccg
     1561 acagtggcgc gcagggtgcg gccacccact cccccggcgt cgtctccggc aacgccatcc
     1621 aggtgccggt gcacgttccc gtcaacgtgt gcggcaacag catcaacgtc atcggtctgc
     1681 tgaacccggc gttcggcaac acctgcgtca acgactgacg tacggccgtt cggcgtacag
     1741 cgcctgacgc agagtcggca cagcggcggt cgtccccggt tccgggggcg gccgccgttt
     1801 cgtgtgcgcg cgcttgaagt cggagtactc cggtaccccg tatggacgtc cgtccggcgg
     1861 gtcgtcgggc gcccgccgcc ttccttctca cctgcgccga tgccggtttc cccgagagcg
     1921 acacgccaca gtgcgtggtc gctcggttgc ggacggtggt tgccgtttag acggtgatca
     1981 caggatctga cgcatcaccg aaagggaact gacccatgcg agctctgcct gtacggcgca
     2041 ccgcgaccac cttcctgtgc accgccctcc tgctcggcac cgcggggccc gtctacgccg
     2101 cgacccacga cgacacggcg cgcgaggccg tggccgccgc gccacaggca cccgtccccg
     2161 gcgccgacgc gctcctggcg caggtgaaga cgctcggcga catcggcggc gtcctcaagc
     2221 cggtcaccga cctgctcgac accgccctga aggcggacaa cggccagctt ccggcggcgg
     2281 acgccgcgaa gctcggggac gccgtcaagg ccgcgatcgc cgcggtcacg gcggcagccc
     2341 ccaagggcgc agaactcccc gcgaccccgc agctcccggc gaccccgcag ctcccgctgg
     2401 gcggcgcgcc ggccgcccag gcgccgatgg acctcaaggg cgacgccctg gccgcgctgc
     2461 agaaggcggt cgacaccctc ctcaaggccg tcaccggcgg cgacccgacg gccgtcctgc
     2521 cggcggcgac ggcggtcgtc accggcctgg tcaacgtcgt cgtcgccacc gtcctcggcg
     2581 gcggcctgcc ggtgccgaac ctgcccggcc tgcccgcgct gcccaagctg ccgaccgacg
     2641 cgctgccgct gcccaagctc ccggtctgag gccgccgcgc cccgcacctt cgccccccgc
     2701 cgctcccgta ccccggagcg gcgggtggct tcgtcaaccc cgtccgaaaa tacgcctgtt
     2761 gatatgagaa atggcggccc ttattcatcc gtgcgggccg ggggaagttt cctctcaggg
     2821 gtttccgtag cgtcctgcgc tcgttaggcg tagtgaactc gagagacagg cattcgctgc
     2881 ctgaacggtg cccccatagg cgatcgaagt cgccgaagaa aggaacacga tgaagtccct
     2941 caaggctgcc gctgtcctgg ccgggtcgat ggccgtcgcc ggtgtcgccg cgcccgccat
     3001 ggccagcgac ctgacgccca ccagcctgaa cggcggcctg gagaccgttc tcggccagtc
     3061 gatgctggac accaagccgg tcagcacgaa catgctggac accgagaaca aggactccgt
     3121 cgtcaacacc gtcacggacg ccgcggagag tgtgaaccag ggcggcggtc ccgcgaagct
     3181 gctcggtgga cttccgctcc agaagtagtg gacttcccct caccgagccg tcgcgtaatg
     3241 ggggaatgag gggcgagaac gtgtgggcgt gttattgcga agctttccgc attcatgtcc
     3301 ataggctggc gtaaacccaa ggaaaggttt tgatcatgaa gaatgtcaag aaggccgcac
     3361 tcgtcatcgc cgccgccgga ctcgccgcgg gtgccgcgtc cggcagcgcc ttcgccagcg
     3421 gtgacggcgc cagcgccgag ggcgcggcgg tcggctcccc gggcgtcggc tccggcaacc
     3481 tcgcccaggt cccggtgcac gtcccggtga acgtggtcgg caacaccgcc aacctgatcg
     3541 gcgccctcaa cccggcgttc ggcaactcgg gcaccaacga ctgaaagccc ctcggggacg
     3601 cctccgcacc cggaggcgaa agggccggtc cggcgacaca ccgccgggac cggcccttcg
     3661 tcgtcggcgg accggacgcg tcaagtccga tggcccgctg accccatcgt gtgatgccgt
     3721 ttccgcgctc cgccagacag gtgacaaagg gattcgggcg gccctcacgc gtctatagcg
     3781 tgcagcccat gacctcaacc tccaacgaac agcgcacctt ccgggtgacc gacctcggca
     3841 ccctcgccgt cctcgcctgg agcggcgaac acccggagga cgagcaggac atggccttcc
     3901 tcctggccta ctccctgggc gacgccgaag gcggacccga ggccacggcc gaggccatgc
     3961 gcaccctcct gcgcaacgag caactgcccc tcggcggacc cgtcctcgac ggcgcccgca
     4021 ccccctccct gccggtcagc ctcctcgtcg aggccgagca ggccgtcgtg aacatgcccc
     4081 acgtcaaggc gcagtgcgtc gttccgcccg agtggctcgc cgccgtcgaa cagcgcggcc
     4141 acgcctactt catgatcacc accgtggcat ggcccgaggg caagcccggc agccccgtct
     4201 ccgaggaggc gctgcgcgac ttcgccgggt ccgaggacac catgctgaac gcggcccact
     4261 gcctgctgcc cgtgcgcagg ctgcgcgcct gatgcgcacc gtcgcgacca cgggacgggt
     4321 accggcgcag gtctccggag cccggcccgc caccgccccc cggccggacg actcccggac
     4381 ggccgggggc gggcgcggcc tcgccctgct gctcgtgctc acggcggcgg cggggctgct
     4441 cgcctcctgg gtcatcaccc tcgacaagct ccggctcttg aaggacccgg actacgtccc
     4501 cgggtgcagc atgaacccgg tggtgtcctg cggcagcatc atgaagagcg agcaggccgc
     4561 ggtgttcggg ttccccaacc cgctgctcgg cctcgccgcg tacgccgtcg tcctctgcgt
     4621 cggcgcgagc ctcctcgccg gggcccgcct gccccgctgg tactggctga cgttcaacgc
     4681 gggcacgctc ttcggcgtcg gattctgcac ctggctgcaa ttccagtcgt tctaccgcgt
     4741 caacgcgctg tgtctgtggt gctgtctggc gtgggccgcc acgatcctca tgttctggta
     4801 cgtgacctcg cacaacgtgc gccatggact tctgcccgcg cccgcgtggc tgcgtacgtt
     4861 catgaatgac ttcacctggg ttctcccggt gctgcacgcg ggcgtcatcg gcatgctgat
     4921 tctcacccgt tggtgggatt tctggatgag ctgaccgcga tttcgtcgaa agcgtccccg
     4981 ggcgggagga gaatgccgcg gtgtcgtccg taagcagagt cagcggagcc aaccggctga
     5041 agcgccgtca tctcatcgcc gtcgcggccg cggcggccct cggagccgtc ggcgcctttc
     5101 gcgggctgcg cgagaaggac gagcgggagg ggctgccggg ggcgcccggc gggcccgggt
     5161 tcgacgagac gtaccgcggc cggcgcatcc agggcgagcc cacgacgggc gagcgcgagc
     5221 acgggcccga cggctggcgg gtcaccgtcg acgggcagcc gctcggcctg atgcgccgcg
     5281 ccgacggcag ctacctgagc atggtggacc actaccagtc gtacgcgacg cccctggcgg
     5341 ccgcccgcgg cgcggtcgac gaactcggct cgtaccagac cctgagcggt cgactccact
     5401 gagccgcccg caccgggacc ggagaacgga cggagagcga ctgccatggc ctacacgcgc
     5461 aagaaccaga acagcctcag ccgggccgag cggcgccggt tcgtcgacgc cgtgttgcgc
     5521 ctgaagcgcc ggggcgagta cgacgagttc gtgcgcacgc acatcgactt ctacgtctcc
     5581 gacggcgacg accggctgcg cgtcgcccat atgacgccca ccttcctgcc ctggcaccgc
     5641 cgcttcctgc tcgacttcga gcgggcgctg cgccgcatcg acgacagcgt caccgtgccg
     5701 tactgggact ggacgaagga ccgcagcccg gccgcgtccc tgtggggcga ggacctgatg
     5761 ggcggcaacg gccggcgctc cgaccggcgg gtcatgaccg gtcccttcgc ccgcggcaac
     5821 ggctgggtcg tcaaggaggc cgtcaccgac ggcgacttcc tcacccgcga cctcgggcgc
     5881 cgcgccgacc cgctggagct gccgacccgc caggacgtgg cctgggcgat ggcggagacg
     5941 gtgtacgacg tcgagccctg ggactccacc tcacggcgcg gcttccgcaa ccgacttgag
     6001 ggctggacgg aggagagcgg cagcgcgcgc tggcgcaacc acaaccgggt gcaccgctgg
     6061 gtcggcgggc acatgctcgg cggcgcctcc gtcaacgacc ccgtcttctg gctgaaccac
     6121 gccttcgtgg acctgctgtg gagccggtgg cagcgaaagc gccccgactc cgccccgttc
     6181 ctgccggcca agccgcccac cctcggcgac gcgcagtacc agcgcattgt cgcccgccgc
     6241 gagccgatgc cgccgtggcg gacgacgccg caggacatgc tcagccacaa gtcggtctac
     6301 cggtacgccg agtagcgccg ccccggcggg gggccgcccg ccggggcggc acccgcacac
     6361 agcggagccc ccggccgatg ccgggggctc cgcttcggcg tcacttgccg tagccgccgt
     6421 gcagctcgcc cttgttggcg cactggttgc cgaacgccgg gttcagcagg ccgatgacgt
     6481 cgacggtgtt gccgcagacg ttcaccggaa cgttgacggg gacctggatc aggttgcccg
     6541 agagcacacc gggggagccg acggccttgc cctgcgcgcc cgcgtccgcc gaggcaagcg
     6601 cggcaccgct gagtacgacg gcacccgcgc cgagcgtgac ggcggctgcc ttcgcgatgc
     6661 gagacatcac gttctccttt gactggggaa atacggccgc atagggacgg ccgcagttcc
     6721 tctaacgcac gttgttgaca cgaagtcacg ccgggtgagg ctttgcgtat tcgtgtcgta
     6781 cgaggggtcg aggaatgccg gaaaacaccc cgcggcggcg tgcgcttcct gagtgacagc
     6841 gttccgtggg ccgtatcctt caccgcgccc gggcgtttgt gagggcatga catcagcacg
     6901 ccgaatcatg gccgccgtct cccttgccgc cggtgccgcg gcgctcgccg cgcccgccgc
     6961 gcacgcgtcc accgacgcgt cgaccgcgtc caagatctcc gtcctggaca cgatcgacga
     7021 gctgcagacg tcgagcatcc ccgccgagcg cagggccgag gtgcccaagg tcgccgacca
     7081 gctcggcggc ctgcaccagc tgcaccaact gcaccagctc accgacctgg tggcgcccgt
     7141 gaccaacgcg gtgcccgccg tccagtagcc cgcggccgac gctcgcggac aagccgccta
     7201 cagcagccgt acccctcgcc tggccaggta ggagacgggg ttgatgtccg agccgtagcc
     7261 gcgccgggcc cgtatctcca agtggaggtg cgggcccgtg gcacgtccgg tggcgccgct
     7321 gtagccgatg cgggcgccgg tgcggatgcg ctggccctgg cgcaccgaga tccgcgagag
     7381 atgcgcgaac agcacatagc gtttgtccgg catccgtacc gtcactgcct tgccgtacgc
     7441 ccccgaccag cgggcgagca ccacgacccc gctggtcacc gcgtacaccg gggtcccgcg
     7501 cggcaccccc aggtcgatgc cggtgtggtg cccggcggcc cagttgccgc gcacgccgta
     7561 gcgcgaggtg acgcggtagc ggcggcgcag cggccgggtg tagcggccct tgggggccgc
     7621 cgcggcgccg aggccgcggc tgtcctcctc ggggagcagg gcctccgcgg cggcgaggtc
     7681 ggcctcgaac tccgcgtcga agtccgcgac gcaccagtcc tcggcgtcgg ggacccatag
     7741 ctcgcccggc gcggtccatt cgtcgtcgtc cgccgacgcg gggggcgccg tcgtcactgc
     7801 cagcgcgcca ccggccagca gtcccgcggc cagaccgagc gcgtcccgtc gtgtggtgcc
     7861 cgcttcgcgc gggccgtcta tgtcgtagcc catacctgca agcacacgcg tgacggcacc
     7921 ggcacgcacg gccggttggg ccgcatggcg taagggcggg gcgccgggcc cgcggcccgg
     7981 cgcggggtcg tggctcccgg cgcgggtggc cgggtgcggg gcgcgggcgg acgggtgccg
     8041 ggcgcggggt gcccacggga gagtgaacgg ccgcgggagt catgtccggc gtcgtgcctg
     8101 ccttcctggc atccgcccac gctaggctcg atcgcgtgac ggctcatcag cgggtggagc
     8161 gagcagcgga cgcgtacact cagcacgctg aggcgtccta ctcggctgtg gccatagccg
     8221 catcggcagg cggcgtacat ggtgtggccg tgctgctcgg cgccctcggc cccgaactct
     8281 cggtgcccgt cctcctcgta cagcatctgg acccccgcca ccgcacggtc atcgccgagg
     8341 tgctcggcag gcgcaccccg ctgcccgtga agctcgcgga gcacgacgag cgggccctgc
     8401 ccggcaccgt gtacatcgcc ccgccggacc ggcacctcct ggtgggcgcc gacggcgtcc
     8461 tcacgctctc cagcagcgcg cgcgtgcact tcgtgcgccc gtccgccgac ctcctcttcg
     8521 agtccgtggc cggcgcgtac gggcaccggg cgatcgcctg cgtcctgacg gggacgggca
     8581 gggacggcgc catgggcgtc gacgcggtga agtcgcgcgg cggcaccgtc atcgcacagg
     8641 atccgagaac ggcggagttc agtggcatgc ccgaggccgc cgtgggtacg ggcgcagtgg
     8701 acttcgtgct acccctggag gagatcgcgg cgatcatccg cgggttggtc gagggcaaga
     8761 ggcaatgatg ggtgacgtac aggacgcgga gacggacgag gggctggagg accttctcgg
     8821 ctttctgcgg gacgcccgga gcttcgactt cacgggctac aagcgttcct cgctgggacg
     8881 ccggatccgc aagcggatgt ccgacgtcga cgtggcgacg tacgcggact accgcgaccg
     8941 tctggagacc agcgcggagg aattcagcgc gctgttcaac accatcctga tcaacgtcac
     9001 gtccctcttc cgcgaccccg actcctggac gttcctgcag cgggaggtcg tccccgaact
     9061 gctcgccgac aaggagccgc aggaagagat ccgggtgtgg agcgcgggct gctccagcgg
     9121 tgaggaggcc tactccctgg cgatcatgtt cgccgaggcc ctgggcactg aggaggccct
     9181 caaccgcgtc aagatctacg gcacggacgt cgacgaggag gcactgcggg acgcccgcac
     9241 cgccctctac agcgccaagt ccctcgaagc gctgcccgcg gagctgcgcg agaagtactt
     9301 cgagcagaac ggcgcgcagt acagcttccg gcccgacctg cggcgccggg tcatcttcgg
     9361 gcgccacgac gtgacccgcg acgcccccat ctcccgcctc gacctgctgg tgtgccgcaa
     9421 cacgctgatg tacttcaacg tcgaggccca gacccagatc gtggaccgct tccacttcgc
     9481 gctgcgagag agcggatttc tcttcctggg caaggcggag atgcttctca acgacgccga
     9541 ccgcttcgag gtggtcagta tgcgccagcg cgtcttccgg cggcgcccgg gcgattccgg
     9601 gccgccctac caacccgcac cgctgaagat cagagccatc gcaggttcgg aacagcgcac
     9661 ggtggcgcgc aaccggcaga cgcgcgacct gatcctcgac gccatccccg tcccggcggt
     9721 cgcggtcgac tccgagggcc tcgtcgcgtt gatcaacagc aacgcccggg tgcagttcgc
     9781 cctgaccacg aacgatctcg gccgcccctt ccaggacctg gagatctcct accggccggt
     9841 cgaactgcgc tccctgatcg agcaggccac gcacgagcgc agaacgctgc gggtcgaccg
     9901 cgtcgagcgg cgcgtgggcg aggacgtgca gtacttcgac atcctcatcc agccgctcac
     9961 cggccccaac ggcctggccg cggccacggt catctccttc accgacgtca cggtcaccac
    10021 ccagctcaag tcggagataa agcgggtccg cgaggagctg gagacggcgt acgaggaact
    10081 ccattcgacc aacgaggagt tggagacgac gaacgaggag ctccagtcga gcatcgagga
    10141 gttggagacg acgaacgagg aactccagtc gaccaacgag gagctggaga ccaccaacga
    10201 agagctccag tccggcaacg aggaactgga gacgatgaac gaggagatgc gcatccgcag
    10261 tgaggagctg gacgaggccc gcgccttcct cgaaggcgtg atgagcagcg tcgccgcggg
    10321 tgtggtcgtc ctggacgcgg agaagcgggt caagagctgg aaccgcggtg ccgccgagct
    10381 gtggggtctg cgcgcggacg ag
//
