LOCUS       NZ_RHGC01000002        22712 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig002, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000002
VERSION     NZ_RHGC01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1226588)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 1226588)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1149363
            Orig. end                         :: 1172075
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22712
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="7"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22712
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22712
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12712](+)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12712
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(444..456)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 16.54"
                     /tool="antismash"
     gene            complement(1049..1303)
                     /locus_tag="EJ355_RS39535"
     CDS             complement(1049..1303)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS39535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_240044807.1"
                     /transl_table=11
                     /translation="MVTSILPEVSSGAASAASMARSAVLQNVTLPPVFVPPFGAASDVA
                     SPPDPAFSPPASAFASPEPDQDRAEGLIPPREVVLLVRA"
     gene            1248..1622
                     /locus_tag="EJ355_RS12090"
     CDS             1248..1622
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025382.4"
                     /locus_tag="EJ355_RS12090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_240044832.1"
                     /transl_table=11
                     /translation="MDAADAAPDDTSGRIDVTMVNRGSTTCSATGFAGVDIKDADNTSN
                     PVERGQAQPRVTTLGPGDAAVFNLAYGIDSTGDSLTSPTDIEVTPPNETHSVPLAWPEG
                     AGAIKGAYTDVQVYPTHTTD"
     gene            1770..2531
                     /locus_tag="EJ355_RS12095"
     CDS             1770..2531
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006128956.1"
                     /locus_tag="EJ355_RS12095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_087887238.1"
                     /transl_table=11
                     /translation="MAWPIAEVARMSGVTARTLRHYDDVGLLPPAWIGANGHRYYEERQ
                     LLRLQQVLVLRELGLGLPEIGRILAAQVDEVEALRGHRRRLLAERDRLDALAGTVARTI
                     TELEQSRKDGTDMISISRPENLFEGIRSTRCMKVLSGFPELVGAVERRTAALSEVEIEA
                     DERERTAQMIRLAELLATGLPADADPVQAEIDAQYRTLARSRAATAEEYLAIGRCCVEN
                     EHWRAAYESIAPGLAAYQRAAIEAYVATRLR"
     misc_feature    1824..1826
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2648..3208)
                     /locus_tag="EJ355_RS12100"
     CDS             complement(2648..3208)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027107.1"
                     /locus_tag="EJ355_RS12100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_087887239.1"
                     /transl_table=11
                     /translation="MVAAGAALADEVGLANLTMGLLAERLGVRTPSLYKHVGGQKDLNR
                     RIAALALNEAAEAVGGAVQGYAGRDALAAAARAFRAFILEHPGRYAATVGVEPDGPDDP
                     LSTAGQRLLGAFTAVLRGYEIQEPDVDHALRTLRSLCHGFATLQVASGFQMSADIDESF
                     EWLIAFTDRGLRALSRPSAGEAP"
     gene            complement(3231..4067)
                     /locus_tag="EJ355_RS12105"
     CDS             complement(3231..4067)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-258). E-value:
                     1.5e-22. Score: 72.3. Matches aSDomain:
                     nrpspksdomains_EJ355_RS12105_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011027106.1"
                     /locus_tag="EJ355_RS12105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_087887240.1"
                     /sec_met_domain="PF00561 (E-value: 1e-16, bitscore: 57.3,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-22, bitscore:
                     76.4, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEYLAVDGGTIAYEVQGSGPLIVLAHGIGDSRAAYRTVVPPLVA
                     AGYRVATVDLRGCGESSVGWPAWSRTAIAGDLLAVIRHLGGPAVLVGHSVSGGAATVAA
                     AREPSLITEVVELAPFTRKQSIRRGDLRVKRFRQGMLRLLGAGAFGSRSLWRSYLDVAY
                     PGVKPADWAERLGRIDSLLREPGRMKAMQSMGRSAPTDAGAQLGNVRCPVLVVMGTLDP
                     DWADPHAEGSAIVDALPTGLGRLEMIEGAGHYPHDQFPDQVVSLMLGFLRPDSARA"
     aSDomain        complement(3294..4007)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS12105_Abhydrolase_1.1"
                     /evalue="1.50E-22"
                     /label="EJ355_RS12105_Abhydrolase_1.1"
                     /locus_tag="EJ355_RS12105"
                     /protein_end="258"
                     /protein_start="20"
                     /score="72.3"
                     /tool="antismash"
                     /translation="PLIVLAHGIGDSRAAYRTVVPPLVAAGYRVATVDLRGCGESSVGW
                     PAWSRTAIAGDLLAVIRHLGGPAVLVGHSVSGGAATVAAAREPSLITEVVELAPFTRKQ
                     SIRRGDLRVKRFRQGMLRLLGAGAFGSRSLWRSYLDVAYPGVKPADWAERLGRIDSLLR
                     EPGRMKAMQSMGRSAPTDAGAQLGNVRCPVLVVMGTLDPDWADPHAEGSAIVDALPTGL
                     GRLEMIEGAGHYPHDQ"
     CDS_motif       complement(3753..3812)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS12105_0001"
                     /evalue="2.30E-02"
                     /label="NRPS-te1"
                     /locus_tag="EJ355_RS12105"
                     /protein_end="105"
                     /protein_start="85"
                     /score="7.4"
                     /tool="antismash"
                     /translation="GPAVLVGHSVSGGAATVAAA"
     misc_feature    4300..4314
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.4"
                     /tool="antismash"
     gene            4307..4747
                     /locus_tag="EJ355_RS12110"
     CDS             4307..4747
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182441.1"
                     /locus_tag="EJ355_RS12110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_087887241.1"
                     /transl_table=11
                     /translation="MAIQRMDNVGIVVEDMDAAIAFFVELGMELEGRAVAEGPVADQCT
                     GLDGVRCDIAMVRTPDGHSRLELAKYHSPAVIGDGPRNRPHNILGTHRVMFAVDDLEDT
                     VARLRPHGAELVGEIARFEDSYLLCYVRGPEGIIVGLAEQLR"
     gene            complement(4821..5939)
                     /locus_tag="EJ355_RS12115"
     CDS             complement(4821..5939)
                     /EC_number="1.14.19.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0016717 - oxidoreductase activity, acting
                     on paired donors, with oxidation of a pair of donors
                     resulting in the reduction of molecular oxygen to two
                     molecules of water [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020132722.1"
                     /locus_tag="EJ355_RS12115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl-CoA desaturase"
                     /protein_id="WP_087887242.1"
                     /transl_table=11
                     /translation="MTAIDPTAHLTSEQIEELGRELDAIRDEVIADRGEKDAAYIRKVI
                     SAQRKLELASRGVLLFSSFPPAWLLGTAGLSVAKIMDNMEIGHNILHGQWDWMRDPKIH
                     STTWEWDHVSPSDQWKHSHNELHHTYTNVIGKDNDLGYGIMRVDEDQKWHPVHLGQPLW
                     NFINACFFEYGIAAYDLELGKNLHKRRRKNPEFRARAKAVGRKIRKQVLKDYVIHPLLS
                     GPSFLSTLGATFTANLVRNVWSHSVIMCGHFPEGVQVFERRSIEGETRGQWYLRQMMGS
                     ANISGSKAMHFMTGNLSHQIEHHLFPDLPSNRYAEVAVKVRALFEKYELEYVTGPLPQQ
                     VFSAWRKVFRLSLPNKTPHVEVPDREQVLVAA"
     gene            complement(5947..7002)
                     /locus_tag="EJ355_RS12120"
     CDS             complement(5947..7002)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1094: ferredoxin"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007262664.1"
                     /locus_tag="EJ355_RS12120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ferredoxin reductase"
                     /protein_id="WP_125262794.1"
                     /transl_table=11
                     /translation="MTSAALRSRAWNLLEMVTTPLLPSDYLDLFSPLRAGADLRGRIEA
                     VRPETGDAATIVIRPGRGWRGHTAGQYVRIGVDVDGVRLWRAYSLTSPTDRRDGRVTIT
                     VKAIPDGKVSNHLVRRAKPGTVIQLDQPTGDFVLPRAKPAKVLYLTAGSGITPVMGMLR
                     DTEFDDVVMVHCAPRPQDVIFRSELHDLVADKKLRLTEVHTDTDGMLDIARIDALVPDW
                     AERETWACGPAGLLDAAEEHWSGHGVQERLHTERFRPGVVVTGDGGEVTFSATGKTVDA
                     DGATPLLDVGEEAGVLLPSGCRMGICFGCVTPLKAGAVRDLRTGEITEAEPGVLIQTCV
                     SAAAGPCDIER"
     misc_feature    complement(7079..7094)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 19.23"
                     /tool="antismash"
     gene            7090..8229
                     /locus_tag="EJ355_RS12125"
     CDS             7090..8229
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560459.1"
                     /locus_tag="EJ355_RS12125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PucR family transcriptional regulator"
                     /protein_id="WP_087887243.1"
                     /transl_table=11
                     /translation="MSHAIRRASELALDETTVTALRAALKTTADEVVQAIIDEVPSYAN
                     ALSGRMGATIRRAVRTALGHYLDLASGHATGGDAGDAAYELGRGEVRDGRSMDALLSAY
                     RVGARVAWRCLAAGAVPAGLPAAEVAKFAELTFAYIDELSAASAAGHADELAARGRAQE
                     RHLEHLARDLLAGASPDVLLASVQRAGWQPPVSLTAVLLPADQARPAYRALDPNTLVLD
                     DLPDATGVLLVPDADRAHLLRHLTDRTAVVGPARPWTRAFASYARAVRARTLSSDIRDT
                     EDHLPELVLSADADAYADLRARALAPLRTLPVGTARRLEETLRAWLLHQGRRDEVAAAL
                     FVHPQTVRYRMSQLRELFPDLASPHRVLELTLAVGLRGS"
     misc_feature    8269..8283
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            8282..8620
                     /locus_tag="EJ355_RS12130"
     CDS             8282..8620
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006374521.1"
                     /locus_tag="EJ355_RS12130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioredoxin domain-containing protein"
                     /protein_id="WP_125262795.1"
                     /transl_table=11
                     /translation="MTKRVHRPREDAEFDFILGASGVPVLAYFIGTWPKAIEPCRATDL
                     VVGDIADHCAGRLTAVRADITRCPAATERYGVTGAPSYVLLKEGEAVAHASGPMTVTEM
                     RNFLDGHL"
     misc_feature    complement(9738..9751)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     gene            10001..12712
                     /gene="lanKC"
                     /locus_tag="EJ355_RS12135"
     CDS             10001..12712
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF038151.1"
                     /locus_tag="EJ355_RS12135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_125262796.1"
                     /sec_met_domain="micKC (E-value: 1.9e-214, bitscore: 710.2,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 6.9e-10, bitscore: 34.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.3e-08, bitscore:
                     30.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEAQYEAFCAADPDFYDRRGHDLTDEALFPPLREAAAPRGWRRIA
                     ERAWVYYQPAGVHIPAQGWKVHVSAAVDRSADVVQVVYDYCLARALTFKVVPGAREYRR
                     RNAKYAERAGSGKLATIYPLDEDDLRTTVTDLGELLDGTPGPYVLSDLRWADGPVYVRY
                     GAFAPRTLTGPDGRETVAIEDADGNLVPDPRGPVFSIPDWVQLPAFLKPDLDRRNATRV
                     DHLPFEIVRALHYSNGGGVYEGRMRADGEKVAVKEGRPHAGVDGGGRDAVTRVRRERDI
                     LRRLAGLPAVPRLKGCHSAAGHEFLVEEFVPGESLFTAAVRRNPLVDDSPPSPERLAAF
                     RDWAMSTWERVAEAVADLHRRGVVFGDLHLYNILVPTQSEEAAGARQVRLIDFEAGWFA
                     DEGGRQVMANPGFAAPRDRTGKDVDLYALAALKLAVFGPLTSLIPLNPAKAAQLAGVIA
                     DRYDVPREWFADALETLTGHAPAAPVPCRVDFGPAAWADVRSSITEAIAASSSPERDDR
                     VFPGDIAQFHHSDAGLGLAHGAAGVLWALRTAGAREVPAAERWLLDRVHRDEPDGRAGL
                     YDGRHGIAYALWELGHRDAAVAVLARIPQAATTPDTGLGLAEGLAGMGLNWLHFARACG
                     DDRYLQRALDTADHVRARLGEVTDVPETSGGAHPRAGLMHGSAGPALFLTTLYEATGDP
                     RHLDAAATALRQDLRRCAYSESGTGAEGGAGTDDGTRPARPQGGALFVNEGFRLMPYLA
                     EGSAGVGIALDRYAAHRQEPEFVTALAAIRRAVAPSFCPFPGLFEGAAGLLLFNAHHAD
                     SPGTAARQVRILDWHVLRWRDHIAFPGTNLLRMSMDLATGGAGVLLALAAVHEKKRTTV
                     QRPSLPFLWPPEPRAEPSGPSPNPVTTTPERR"
     gene            12718..12861
                     /locus_tag="EJ355_RS38515"
     CDS             12718..12861
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS38515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_161990292.1"
                     /transl_table=11
                     /translation="MAIYDLQGLGAETSAELGDLSNSNATSVFCCVPSPNLSSLSITCR
                     DC"
     CDS_motif       12718..12774
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAIYDLQGLGAETSAELGD"
                     /locus_tag="EJ355_RS38515_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       12775..12861
                     /prepeptide="core"
                     /locus_tag="EJ355_RS38515_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="0.70"
                     /molecular_weight="2757.1"
                     /monoisotopic_mass="2755.3"
                     /core_sequence="LSNSNATSVFCCVPSPNLSSLSITCRDC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAIYDLQGLGAETSAELGD"
                     /leader_location="[12717:12774](+)"
                     /alternative_weights="2775.1"
                     /alternative_weights="2793.2"
                     /alternative_weights="2811.2"
                     /alternative_weights="2829.2"
                     /alternative_weights="2847.2"
     misc_feature    12888..12901
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.47"
                     /tool="antismash"
     gene            12945..14810
                     /locus_tag="EJ355_RS12140"
     CDS             12945..14810
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="EJ355_RS12140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_125262797.1"
                     /transl_table=11
                     /translation="MPQRRLLGVLRPHRARVALLLVLIVALAATTVAPAVVAQRLIDHG
                     VLRRDEGMVWAMTGALAALGAAQAALTYLERRFATRLAEDVVLRLRTDVFAHLQRQSLG
                     FFSVARTGALVSRLHGDVAGVQQVVAGTLPAAVSALFLLLTTGLTVTVMEWRLAGLVLL
                     LIPLLYLLTSHFTIALRKVNQRMLGAFADLDSLVAERLSSGGAEVIRHYGHPDRDAPRF
                     RLLAARVRDTSVRRASLAAALTGSLVLMVSLVTALIYLVASRLAISGTLTLGTVIALLS
                     LLARLFGPLTALPGLRVELIAGRVAFDRIQEVLEFEPQIVDAPDARPLPVRADRAPSVE
                     FRHVDFAYPPPHDLAVPSLTGDQDADLADEADGHLDEELFDGDPTTDAHGPRAALTALS
                     FIAAPGTTVGIVGLSGAGKSTLTRLLTRSFDVGAGRVLIDGVDIRRLRLDDLRSAIGIV
                     PQETFLFNDTVRANLLLARPAATTEELEAACRDARVWSTVEKLPDGLDTLIGDRGLRLS
                     GGERQRLALARLVLKGPPIVVLDEATSHSDTVTEQEIQESMGEFLRSRTCLVIAHRLST
                     VRDADQILVMREGRVVERGPHQELLGAGGWYARLHRAQHRVPVAR"
     gene            complement(14912..15436)
                     /locus_tag="EJ355_RS12145"
     CDS             complement(14912..15436)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007504155.1"
                     /locus_tag="EJ355_RS12145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding protein"
                     /protein_id="WP_087887250.1"
                     /transl_table=11
                     /translation="MIVWLNGTHGAGKTTTSALVQKLIPDSRVFDAEKVGETLMDITPT
                     LPWTGNFQHWPPWRPLVVETARHVLDYTGGTLVMPMTVLVEEYWREISTGLARHAVPVR
                     HFVLHADQDTLRARIAGDTVLGPDSPFRLQHLEPYAEAARAWLHEAAEVVDTTHLTPDQ
                     AAQQIADAVKS"
     gene            complement(15778..17475)
                     /locus_tag="EJ355_RS12155"
     CDS             complement(15778..17475)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006127182.1"
                     /locus_tag="EJ355_RS12155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycoside hydrolase family 18 protein"
                     /protein_id="WP_087888063.1"
                     /transl_table=11
                     /translation="MAVGAATALAVTALAAPAQSADTNTAGTKAASTRAADVNVAKNAG
                     FEADLNNWTCAANSGAAVTSPVHGGAKALKATPSGQGTAECSQIVAVKPNSTYKLSSWV
                     QGSYAYLGARGTGTTDVSTWTPGTSSWQQLSTSFTTGANTTSVTVYTHGWYGQSAYYVD
                     DVSVFGPDGGGGPDPVEIPPVPAGLAAGTATPTSVELSWTPSSTATGYTVYRDGTKVAS
                     SSGASTTVTGLTPETTYSFQVSASNAAGESAKSTAVSVTTPKGDGGGDGTVPRHAVTGY
                     WQNFNNGATVQKLRDVSSQYDIIAVSFADATPTPGQITFNLDPAVGYASTADFKADIAA
                     KKAAGKSVILSVGGEKGTISVNSDASATAFANSAYALMQEYGFNGVDIDLENGINPTYM
                     TKALRQLSAKAGPKMVLTMAPQTIDMQSTSGGYFQTALNVKDILTVVNMQYYNSGSMLG
                     CDGKVYSQGSVDFLTALACIQLEGGLDPSQVGIGVPASTRGAGSGYVAPSIVNNALDCL
                     TRGTGCGSFKPSKTYPSLRGAMTWSTNWDATAGHAWSNAVGPKVHSLP"
     misc_feature    complement(17596..17611)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 23.08"
                     /tool="antismash"
     misc_feature    17597..17610
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    complement(17614..17629)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.39"
                     /tool="antismash"
     gene            complement(17681..18292)
                     /locus_tag="EJ355_RS40130"
     CDS             complement(17681..18292)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00481.1"
                     /locus_tag="EJ355_RS40130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YbhB/YbcL family Raf kinase inhibitor-like
                     protein"
                     /protein_id="WP_087887251.1"
                     /transl_table=11
                     /translation="MRSARIALCALLITGAVGLSPTTASATSSTPSPPSTPPANRSAFT
                     LSSTAFADGGVIPKVHECTSGGGSDPGKRNESPPLTWAGAPTAAKSYAIVMRDLDNSNL
                     IHWVIYDIPASATSLPQNVDHAYRPSTPAGARQVYYRGSASLYGYQGPCSPSTVNTYEF
                     VVHALNQPSLSSLNSNSSTRTAAREIIAATIGSARITGES"
     misc_feature    18388..18398
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(18395..19783)
                     /locus_tag="EJ355_RS12165"
     CDS             complement(18395..19783)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009297595.1"
                     /locus_tag="EJ355_RS12165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF418 domain-containing protein"
                     /protein_id="WP_125262798.1"
                     /transl_table=11
                     /translation="MRLQPRKSVTAPVATDAPALAHRDGLATTGRLLGVDLARGLAVFG
                     MYAAHVGPAPEDAGGVTGFFLELSHGRSSALFAFLAGFSLILLTGRSEPRTGSAGRQAV
                     LHVLIRAVVLLALGTALTMTGTPVEVILAYYGLFFALLLPLYRLRPRTLAVLAAVTALT
                     LPQVRHLLLRSLDDGAWGETVIAHDPLARVSDTDGFLDLLVTGSYPALAWLSFLLAGMA
                     VARLDLASRVVRARLAATGAALAVVGHGGSWLALHLLPGVPAALAADAAWDGPVMASWW
                     SDVAGVSETSGTAWLWVAAPHSETTLSIVANTGVALLVLTACVFALDRLPRLTRWARPV
                     IAVGSMSLTAYVLHIVLIWALGIEDLDGLPLLLLPAFIAAAVLLATVWSRFFRRGPLEH
                     LLHGATRLGDTLVRGRTGGGPATARNPAGKPSSATRPVDPSASIRPSETANRRREKYID
                     QVDK"
     gene            19975..20667
                     /locus_tag="EJ355_RS12170"
     CDS             19975..20667
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357743.1"
                     /locus_tag="EJ355_RS12170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_125262799.1"
                     /transl_table=11
                     /translation="MIRVVVVDDEALVRSGFELILSAADDIDVVATATGAEAVETIVRV
                     RPDVVLLDIRMPDTDGLTVLRELRALDAPPVAAMLTTFDSDEYILTALRSGAAGFILKD
                     TAPEQLAHLVRTLDAGGVVLSPKASSAIVDGAHGVAEDDPQVRRVRLLTDRERTVLRLI
                     AEGLSNADIAARLHLSPGTVKDHASSILGKLRVSGRVQAALLAQRAGLLTAKGTERHHP
                     SHDTGPRP"
     gene            20664..21842
                     /locus_tag="EJ355_RS12175"
     CDS             20664..21842
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013006186.1"
                     /locus_tag="EJ355_RS12175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_240044808.1"
                     /transl_table=11
                     /translation="MNQPHQRTPSRTEDARRLAATWATPMIVLLAAADLWWNAEDVKTY
                     EVTWAAAACAALALRSRFPLTVFLIGVPATLFTPLMVVPFASLYALAAASRNRPLLAVC
                     ALVSAAADAAPWPLGDYAHDGATRTLVDFAYLIATAAAPVFLGQLVQARQDAAERLLEV
                     EEARDHERQLHAQNLLARERAQLAREMHDVVSHQVSLIAVQAGALQVSTTEPRAKAAAH
                     TIRELSVTTLDELRHMVTLLRMSGGGASELAPQPTLADLRRLVDGSGIHSTLTGELPAD
                     LPAPVQRTLYRTVQEALTNARKHAPGSRVTVHLWHDLDHIGVTVTNTPPSRPATPLPGA
                     HLGLIGLRERADLLHGHFDSGPTTEGGFTVSLTLPYAPEAQPSGRRESHPRD"
     gene            complement(21909..22262)
                     /locus_tag="EJ355_RS12180"
     CDS             complement(21909..22262)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS12180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_125262800.1"
                     /transl_table=11
                     /translation="MGNWVVIAQYHSDVYRTEFVRAGLETKLQALEALRAALFTYVPSK
                     SLVEKRRRVYRFADQETYLVAIKGKLTQWECTLRVAELVSDSADPAVAEQAQLDGGAAE
                     VADGPRDRIPPGH"
     misc_feature    22687..22701
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.07"
                     /tool="antismash"
ORIGIN
        1 gggcgagggc ggccgtgacg ggagcgcggt ggcctggcag gtgtctggag gcccagtcgg
       61 ccgccagggc gaggaagccg gccagatcgc gttcgacacc ggcgagcagg tcgcggagct
      121 cggtgaggga cagctcgatc accggactgt cgctccggtc ggcgtggacg gtgagccgga
      181 cggtgtcgtc gaagcgctcc gcgatcggcg acgaggggtc gtggccgaat ccgagcaggc
      241 tgccgccgtc gaggaactgg tgccagtcgc gccagtcctc caggccgtcg cagcagccgg
      301 ggaggagggc gacgccggtg gagctgtcgg tgacccgcag gccgccggcc gcgaagagga
      361 cgtcgaaggt cagcagtccg tggaggaacg agccgagtgc gtcggctggg cgaggcgggt
      421 gctcgccgcc ggggtcgacg tcgttgcaac tggcgatacg catcaccgcc gacccgacct
      481 cagcgggtga gagttcaccg ctgagaggca ggaagccgag tggctcgacc tccgcgacag
      541 gccagaggtc gaagccgtca ggtgtgccca tctccaggac gggctccatc acgatcaccc
      601 ggcgaagtgt cccgcatccc ctgcccctgc cgcctcccga ttgcgctgag cacgctcatc
      661 tcggcccgag gagccgagca cttcgggccc atctccagca ggggcggctc ccgccgggca
      721 gagaacgtcc gcgtgcaggc cgagcggctg aaagggtggt ggccattgaa cgcctgtggt
      781 ggttctgccg ccggcagccc ggtcggccga cacgcgccgc ccgcgacggc agccacacct
      841 tcggcgagct gatcgatctc cccgccgcgg ctcgcgagga gctacgacgc cgagccggat
      901 cacccgacca cgcggcggcg tgtaccgtca acaatggcga acgatcgctt ggtgccccgc
      961 aggagtgacg ccgggggccg tcggcagcga ggcggcaagg cgaacagggc cgcactcagg
     1021 gaaggccacg cggccgtccg tcgaccgctc aggcccggac caggagcact acctcacggg
     1081 gcgggatgag gccctcggcg cggtcctgat cgggttccgg cgacgcgaag gcggaggcag
     1141 gcggcgagaa ggcgggatcc ggcggcgacg ccacgtcgga ggccgcgccg aacggcggga
     1201 cgaagaccgg cggcaaggtc acgttctgca agacggcgga cctggccatc gacgccgcgg
     1261 acgccgcgcc cgacgacacc tccggcagga tcgacgtcac catggtcaac cggggttcga
     1321 ccacctgctc ggccacgggc ttcgcgggcg tcgacatcaa ggacgccgac aacacctcga
     1381 accccgtcga gcggggccag gcccagccgc gcgtcaccac gctggggccc ggcgacgccg
     1441 ctgtcttcaa cctcgcctac ggcatcgact ccaccggcga cagcctcacg agcccgaccg
     1501 acatcgaggt gacgcccccg aacgagaccc acagcgtgcc cctggcctgg cccgagggcg
     1561 cgggcgcgat caagggcgcg tacaccgacg tccaggtcta cccgacccac accaccgact
     1621 agaggccgtg cccgcagccg acctggtggc cgccgacagg cgcgcgccaa gctgagagcc
     1681 gggcttgagg ctgccgcagc ggcagcctct accgtcctga gcgggggcgg agactccggc
     1741 ccggtgatgc acgcgtgtgg gaggcggcga tggcctggcc gatcgcggag gtcgcccgga
     1801 tgtcgggtgt gaccgcccgg accttacggc actacgacga cgtcggactg ctgccgccgg
     1861 cctggatcgg ggccaacggc caccgctact acgaggagcg ccaactgctg cggctgcagc
     1921 aggttctcgt gctgcgggag ctgggcctgg ggctgcccga gatcggccgg atcctggccg
     1981 cgcaggtcga cgaggtggag gccctgcggg gccatcgccg tcggctgctc gccgagcgtg
     2041 accggctgga cgccctggcc ggcaccgtcg cgcgcacgat caccgaactg gagcagtcca
     2101 ggaaggacgg cacagacatg atcagcatca gccggccgga gaacctgttc gagggcatcc
     2161 ggtccacccg gtgcatgaag gtcctgagcg gtttcccgga gctggtcggg gccgtcgagc
     2221 ggcgcaccgc ggcgttgagc gaggtcgaga tcgaggcgga cgagcgcgag cgcacggcgc
     2281 agatgatccg gctggccgag ctgctcgcca ccggcctgcc cgctgacgcc gacccggtgc
     2341 aggccgagat cgacgcccag taccggacgt tggcccggag ccgggcggcc accgccgagg
     2401 agtacctcgc gatcgggcgt tgctgtgtgg agaacgagca ctggcgtgcg gcgtacgagt
     2461 cgatcgcgcc gggccttgcc gcgtaccagc gagccgccat cgaggcgtac gtcgcgacgc
     2521 ggctgcgctg agccgggaca gggccgccgc cacgggggtg cggcggccct gtcgggtgct
     2581 gcctcgacgg atgaacatgc acacgacgcc ttgaccaagg ggccggacgg aagccgacag
     2641 cgaggaccta aggtgcctcg ccggcgctcg ggcgggagag cgcgcgcagc ccccggtcgg
     2701 tgaaggcgat cagccactcg aagctctcgt cgatgtcggc gctcatctgg aagccgctcg
     2761 ccacctgcaa ggtggcgaag ccgtggcaga ggctgcggag cgtgcgcagg gcgtggtcca
     2821 cgtcgggctc ttggatctcg tagccgcgca ggaccgccgt gaacgcgccg agcagccgct
     2881 ggccggcggt ggacagggga tcgtccgggc cgtccggttc cacgccgacc gtggcggcgt
     2941 accggccggg gtgttccagg atgaacgcgc ggaaggcgcg cgcggcggcc gccagggcgt
     3001 cgcggcccgc gtacccctgg accgcgccgc cgacagcctc ggcggcctcg ttcagcgcca
     3061 gggccgcgat gcgccggttg aggtccttct ggccgcccac gtgcttgtac agggacgggg
     3121 tacgtacgcc caggcgctcg gccagcagcc ccatcgtcag gttggcgagg ccgacctcgt
     3181 cggcgagcgc ggcaccggcc gcgaccacgg ccgccgggtc caggccggcc ctaggcacgg
     3241 gcggagtccg ggcggaggaa gccgagcatg agcgaaacca cctggtcggg gaactggtcg
     3301 tgcgggtagt gcccggcgcc ctcgatcatc tcgaggcgac cgaggccggt cggcagggca
     3361 tcgacgatcg ccgacccctc ggcgtgcggg tcggcccagt cggggtcgag cgtgcccatc
     3421 acgaccagga ccgggcagcg gacgttgccg agttgcgcgc cggcgtcggt cggggcgctg
     3481 cggcccatgc tctgcatggc cttcatccgg cccggctccc gcagcaggga gtcgatgcgg
     3541 ccgagccgct cggcccagtc ggccggcttc acgccggggt aggccacgtc gaggtacgag
     3601 cgccagaggg agcggctgcc gaacgcgccc gcgccgagca gccgcagcat gccctgccgg
     3661 aatcgcttaa cccgcaggtc gccccggcgg atcgactgct tgcgggtgaa cggcgccaac
     3721 tcgacgacct cggtgatcag cgagggctcc cgcgccgcgg cgacggtggc ggcaccgccg
     3781 gagaccgagt ggccgacgag cacggccggg ccgcccaggt ggcggatcac cgcgagcagg
     3841 tcgccggcga tggcggtgcg gctccaggcc ggccagccga cgctggactc gccgcagccc
     3901 cgcagatcga ccgtggcgac ccgatagccc gcggccacca gcggcgggac gacagtgcgg
     3961 tacgcggcgc ggctgtcgcc gatgccgtgc gcgaggacga tcagcgggcc ggacccctgc
     4021 acctcgtaag cgatcgtgcc gccgtcgact gccaggtact cgctcatggc atccctctca
     4081 tccggctaat ctcgttagct aaaagctaat gtcattagcc gcgtctgtca acgacgaagt
     4141 cgccgccgcg ctacggtcgg cagacgcgcc gtgtgcctcg cgtccggccg gttcgccaga
     4201 tctttttggg gttcggcggt ctgtggatgt cgagaacggg tcaccggcac cgtcccaggg
     4261 gcacagcggc caccaccggc cgcacgagga cgaaggagaa gcaggcatgg cgattcagcg
     4321 gatggacaac gtcggcatcg tcgtcgagga catggacgcc gccatcgcgt tcttcgtgga
     4381 actcggcatg gagctagagg gcagggcggt cgccgaggga cccgtcgccg accagtgcac
     4441 cggactcgac ggcgtccgct gcgacatcgc gatggtccgc accccggacg gtcacagccg
     4501 cctcgagctg gcgaagtacc acagccccgc ggtgatcggc gacgggccgc gcaaccggcc
     4561 gcacaacatc ctgggcacgc accgcgtcat gttcgccgtc gacgacctcg aggacaccgt
     4621 ggcccgcctg cgccctcacg gcgccgaact cgtcggcgag atcgcccggt tcgaggacag
     4681 ctacctgctc tgctacgtcc gcggcccgga gggcatcatc gtcggactgg ccgagcaact
     4741 gcgctgagca gggcggaccg aaccgtgccg tcgagcgcga tcagtccggc cgccccgcac
     4801 ctcgacaccg gtaccgggag tcaggccgcg acgagcacct gctcgcggtc cggcacctcg
     4861 acgtggggcg tcttgttcgg cagcgagagc cggaagacct tgcgccacgc ggagaacacc
     4921 tgctggggca gcggcccggt gacgtactcc agctcgtact tctcgaacag ggcgcgcacc
     4981 ttcaccgcga cctcggcgta ccggttgctc ggcaggtccg ggaacaggtg gtgctcgatc
     5041 tggtgcgaca ggttgccggt catgaagtgc atggccttgc tgccgctgat gttcgccgag
     5101 cccatcatct ggcgcaggta ccactggccg cgcgtctcgc cctcgatcga ccggcgctcg
     5161 aagacctgca cgccctccgg gaagtgcccg cacatgatca ccgagtggga ccagacgttg
     5221 cggaccagat tcgcggtgaa cgtggcgccg agcgtgctga ggaacgacgg gcccgaaagg
     5281 agcgggtgga tcacgtagtc cttgagcacc tgcttgcgga tcttgcggcc cacggccttg
     5341 gcccgcgcgc ggaactccgg gttcttgcgg cgccgcttgt gcaggttctt gccgagctcc
     5401 aggtcgtacg cggcgatgcc gtactcgaag aagcaggcgt tgatgaagtt ccacagcggc
     5461 tggccgaggt ggaccgggtg ccacttctgg tcctcgtcga cgcgcatgat gccgtagccg
     5521 aggtcgttgt ccttgccgat cacgttcgtg tacgtgtggt gcagctcgtt gtgcgagtgc
     5581 ttccactggt cggacggcga gacgtgatcc cactcccagg tggtggagtg gatcttcggg
     5641 tcgcgcatcc agtcccactg gccgtgcagg atgttgtgac cgatctccat gttgtccatg
     5701 atcttcgcca cggacagacc cgcggtgccg agcagccatg cgggcgggaa ggacgagaac
     5761 aggagcacgc ccctgctggc cagctcgagc ttgcgctgtg ccgagatgac cttgcggatg
     5821 tacgcggcgt ccttctcgcc gcggtcggcg atcacctcgt cgcggatcgc gtccagctcg
     5881 cggccgagct cctcgatctg ctccgaggtc aggtgggcgg tggggtcgat ggcggtcaag
     5941 gtgttcctac cgttcgatgt cgcaggggcc cgccgcggcg gacacgcagg tctggatgag
     6001 gacgcccggc tcagcctcgg tgatctcgcc ggtgcgcagg tcacggacgg cgcccgcctt
     6061 gagcggcgtg acgcagccga agcagatgcc catgcggcac ccggagggca gcagcacacc
     6121 ggcctcctcg ccgacgtcga ggagcggcgt ggcgccgtcc gcgtcgacgg tcttgccggt
     6181 ggcgctgaac gtgacctcgc cgccgtcgcc ggtgaccacg acgccggggc ggaagcgctc
     6241 ggtgtgcagg cgctcctgga cgccgtgtcc gctccagtgc tcctcggcgg cgtcgagcag
     6301 gccggcgggc ccgcaggccc aggtttcgcg ctcggcccag tcgggcacga gcgcgtcgat
     6361 acgggcgatg tcgagcatgc cgtccgtgtc ggtgtgcacc tcggtgagcc gcagcttctt
     6421 gtccgcgacc aggtcgtgca gttcgctgcg gaagatcacg tcctgcggcc gcggcgcgca
     6481 gtggaccatg acgacgtcgt cgaactcggt gtcgcgcagc atgcccatca cgggcgtgat
     6541 gccgctgccg gccgtcaggt agagcacctt ggcgggcttg gcccgcggca gcacgaagtc
     6601 gccggtcggc tggtcgagct ggatcaccgt gcccggtttg gccctgcgga ccaggtggtt
     6661 gctgaccttg ccgtccggga tcgccttcac ggtgatcgtg acgcggccgt ccctgcggtc
     6721 ggtcggcgag gtgagggagt aggcacgcca caggcgcacg ccgtcgacgt cgaccccgat
     6781 ccgcacgtac tgaccggccg tgtggccgcg ccagccccgc cccggcctga tcacgatggt
     6841 cgcggcgtca cccgtctcgg gacgcacggc ctcgatgcgc ccccgcaggt cggcgcccgc
     6901 acgcaggggg ctgaacaggt cgaggtagtc cgacggcagc agcggcgtcg tgaccatctc
     6961 cagtagattc cacgccctgc tgcggagggc tgcactcgtc atgaccccag cttgctgcgc
     7021 ctcagggcgt aaagtcctga ccgcaggatg tgaatctggt cgacagaatt gttcgtaggg
     7081 aacaaaaacg tgagccatgc gatccggagg gccagtgagc tggccctgga tgagacgacg
     7141 gtcaccgcgc tgagggccgc gctgaagacc accgccgacg aggtcgtcca ggcgatcatc
     7201 gacgaggtcc cttcgtacgc caacgccctt tcgggccgca tgggcgccac catccgccga
     7261 gccgtccgca ccgcgctcgg gcactacctg gacctcgcga gcggccatgc caccggcggc
     7321 gacgccggtg acgcggccta cgagctgggc cgcggcgagg tgcgcgacgg ccgctcgatg
     7381 gacgccctgc tcagcgccta ccgcgtcggc gcccgcgtgg cctggcgatg cctggcagcg
     7441 ggtgccgtac ccgcgggtct gcccgccgcc gaggtcgcca agttcgccga gctgaccttc
     7501 gcctacatcg acgagctctc cgccgcgagc gccgcgggcc acgccgacga actggccgcc
     7561 cggggcaggg cccaggaacg gcacctggaa cacctggccc gcgacctcct cgccggcgcg
     7621 agcccggacg tgctgctggc ctctgtccaa cgggccgggt ggcagccccc ggtctcgctg
     7681 accgcggtcc tgctgcccgc ggaccaggcc cggcctgcct accgcgcgct cgacccgaac
     7741 accctcgtcc tcgacgacct gccggacgcc accggtgtgc tgctcgtccc cgacgccgac
     7801 cgagcacatc tcttgcggca cctgaccgac cgcaccgccg tggtcggccc ggcccggccc
     7861 tggacgcgcg ccttcgcctc gtacgcacga gccgtacgcg cgcgcaccct ctcctccgac
     7921 atccgcgaca ccgaggacca cctgcccgag ctggtgctga gcgcggacgc ggacgcgtac
     7981 gcggacctgc gtgcccgagc cctcgcaccc ttgcggacct tgcccgtcgg gaccgcacga
     8041 cgccttgagg agacgttgcg ggcgtggctg ctgcaccagg gcaggcggga cgaggtggcg
     8101 gcggcgttgt tcgtccatcc ccagacggtc cggtaccgga tgtcgcagct gcgtgagctg
     8161 tttccggatc tcgcatcgcc gcaccgggtc ctagaactga cgctggcggt gggccttcgg
     8221 ggcagctgac gcgcacaggg atgatgggag ggaacgacgg aacgtgagat caggggtttt
     8281 gatgacgaag cgggtgcacc gaccccgtga ggacgcggag ttcgatttca tcctcggggc
     8341 gagcggagtt ccggtcctcg cgtacttcat cgggacatgg cccaaggcga tcgagccctg
     8401 ccgggcgacg gacctcgtcg tgggcgacat cgccgaccac tgcgcgggcc gtctgacggc
     8461 cgtccgcgcc gacatcacgc gctgtccggc agcaaccgag cgatacgggg tcaccggagc
     8521 cccctcctac gtcctgctga aggaggggga ggcggtggcg cacgcctcgg ggccgatgac
     8581 cgtcaccgag atgcggaact tcctggacgg ccacctctga gcggcctccg gcccgcactg
     8641 ctgccggacc gctcacgtcg cctcccggac ctaccgccgg ggtgagctga gccaacggag
     8701 aactcgaact cccggagccg tctccagctc gacgaggccc aggacatccg cgcccaggtg
     8761 ctccaacgac gcgttgttcg agcacctcct ccagcagacg ttcaactgct cgatgatgac
     8821 gtcctccagg cgaggcgact cgccccgggg ggcaggcgtc cgtcagacga agggtgttga
     8881 tctgatccca gccgcgcgct gcgagccgtc cgcgcagatc gagctcgacg gtggcccgca
     8941 ccaccagaca tgcgggctgt gtcagcctga gggccacagc gacgaggatc tccagcgcgc
     9001 tgttcgcgag gtagtgcaca ccggtgaggt cgaccgtgat ctcgtcccct tggccgctct
     9061 ggcctgtgat ggcgagggcg agcggacccc tgtgtgtgct gatgacctcg ccgaacaggc
     9121 gcacgctcgc ggtggtgtcc gaaggcagaa tgaggaggag atcgtctgtg aagtagccgc
     9181 gcatggccag ccccggggta tggcaccacg gggctcggtg acggcagggg cgtgccgaag
     9241 cagtgcctct cgcggtgcgc tgaagcggga tcagggtcct gcctggatca gccgctggcg
     9301 taggggtctc acaccagacc cgagaggtcg cctggagacg ggtgccgcgc tgacggcaac
     9361 agcatgtcca cggtctcgtg gaaatgctac tcgcttgcag cccaccgcaa gagggaagtt
     9421 gtggccatgg gcagacacat ccgaccggtt cgcgtacgcg gacgtctacc cggggcggaa
     9481 cgttgaggtg agctgccgca tgcggtctgc acggtcctgc ggccccggcg ttgatcccgg
     9541 cgcggtgctg cgccagggga ggagcccggc ggcgaccggg tccaggcgcg ctgcgccccg
     9601 gcccctacgc cgactgcacc cccgccgtat tcctgcccgc caacacgccg ttccagtacg
     9661 actgctggta tcagaactcc gtcggaaaca cctggacgca cggcaccgcg acctactccg
     9721 gccgtcagta caagggctgg atctgggacg acaaactccc gggaaacggc agcgacagga
     9781 agtgctagcc acggaagtcg gaccgagggt gactccaagc ctcgtcccac gagagccgac
     9841 ccggccgact cgtgcgcgaa tcgacaagcc ccctgcacga acagacaacg acagctcgcg
     9901 cctgcgcacg acatcttgaa cctgtgccgc ggaggggagc ggccgggcgg cgggggcgtc
     9961 cggccgcagg agaccgggag acaagaatcg gggacggggc atggaagctc agtacgaagc
    10021 gttctgcgcg gccgatccgg acttctacga ccgccgcggc cacgacctca cggacgaggc
    10081 cctgttcccg cccctgcggg aggccgcggc accgcgcggc tggcggcgga tcgccgagcg
    10141 cgcctgggtg tactaccagc cggccggcgt gcacatcccc gcccaggggt ggaaggtcca
    10201 cgtctccgcc gccgtcgacc ggtccgccga cgtcgtccag gtggtgtacg actactgcct
    10261 cgcccgcgcg ttgacgttca aggtggtgcc cggcgcccgc gagtaccggc ggcgcaacgc
    10321 caagtacgcg gagcgggccg ggagcggcaa gctcgccacg atctaccccc tggacgagga
    10381 cgacctgcgc accaccgtca ccgacctcgg ggaactgctc gacggcaccc cgggcccgta
    10441 cgtcctgagc gacctgcgct gggcggacgg ccccgtctac gtccgctacg gcgccttcgc
    10501 cccacgcacc ctcaccggcc ccgacggccg ggagaccgtg gcgatcgagg acgccgacgg
    10561 caacctggta cccgacccgc ggggcccggt gttcagcatc ccggactggg tccagctgcc
    10621 cgcgttcctc aagccggacc tcgatcgccg caacgccacc cgcgtcgacc acctgccctt
    10681 cgagatcgtc cgcgccctgc actactccaa cggcggtggc gtctacgagg ggcggatgcg
    10741 ggccgacggc gagaaggtgg ccgtgaaaga gggacggccg cacgccgggg tggacggtgg
    10801 gggccgcgac gccgtgaccc gggtgcggcg cgagcgcgac atcctgcggc gcctcgccgg
    10861 acttccggcc gtgccccggc tgaagggctg tcacagcgcg gcgggccacg agttcctcgt
    10921 cgaggagttc gtccccggag agtccctgtt caccgctgcc gtccggcgca accccctcgt
    10981 ggacgactcc ccgccgagcc cggagcgcct cgccgccttc cgcgactggg cgatgtccac
    11041 atgggagcgc gtcgccgagg ccgtggccga cctgcaccgg cgcggtgtgg tcttcggcga
    11101 cctgcacctc tacaacatcc tggtgccgac gcagagcgag gaggcggccg gggcgcggca
    11161 ggtccgtctc atcgacttcg aggcgggctg gttcgcggac gagggcggcc gccaggtgat
    11221 ggccaacccg ggcttcgccg cgccacgcga ccgcacgggc aaggacgtgg acctctacgc
    11281 gctcgccgcg ctgaaactcg ccgtcttcgg cccgctcacc tcgctgattc ccttgaaccc
    11341 ggccaaggcg gcacagctcg ccggagtcat cgccgaccgc tacgacgtgc cgcgggagtg
    11401 gttcgccgac gccctggaga cgctcaccgg gcatgcaccc gccgcccccg tgccgtgccg
    11461 ggtcgacttc ggccccgccg cctgggccga cgtgaggtcg tccatcacgg aggccatcgc
    11521 cgcgagcagc agccccgagc gcgacgaccg ggtgttcccc ggcgacatcg cccagttcca
    11581 ccactccgac gccgggctcg gcctggcgca cggagcggcc ggggtgctgt gggcgctgcg
    11641 cacggcgggc gcgcgtgagg tccctgcggc ggaacgctgg ctgctcgacc gcgtccaccg
    11701 ggacgagccg gacgggcggg ccggtctgta cgacggccgg cacggcatcg cgtacgccct
    11761 gtgggagctc ggccaccggg acgcggccgt ggccgtcctc gcccgcattc cgcaggccgc
    11821 gaccaccccc gacaccggcc tcggcctggc cgagggactg gcgggcatgg gcctgaactg
    11881 gctgcacttc gcccgcgcct gtggcgacga ccggtatctg cagcgggcgc tggacaccgc
    11941 ggaccacgta cgcgcccgtc tcggcgaggt gaccgacgtc cccgagacca gcggcggcgc
    12001 ccatccgcgc gccggcctca tgcacggctc ggcgggcccg gcgctcttcc tcaccacgct
    12061 ctacgaagcg accggcgatc cgcgccatct cgacgcggcc gcgacggcgc tgcgacagga
    12121 cctgcggcgc tgcgcgtact cggagagcgg caccggcgcc gagggtggcg ccggtactga
    12181 cgacggcact cgtccggccc gcccgcaggg cggcgcgctc ttcgtcaatg agggattccg
    12241 gctgatgccc tatctcgccg agggcagcgc gggcgtcggc atcgccctcg accggtatgc
    12301 ggcacaccgt caggagccgg agttcgtgac cgcgctggcg gcgatccggc gcgcggtggc
    12361 cccgtccttc tgccccttcc ccggcctctt cgagggcgcg gcgggactgc tgctcttcaa
    12421 cgcccaccac gcggactccc cggggaccgc ggcgcggcag gtccgcatcc tcgactggca
    12481 cgtactgcgc tggcgggacc acatcgcctt ccccggcacg aacctgctgc gcatgtcgat
    12541 ggacctcgct acgggcggag ccggcgtcct gctggccctg gccgccgtcc acgagaagaa
    12601 gcggacgacg gtgcagcgcc cttccctgcc gtttctgtgg cctcccgagc ctcgggccga
    12661 gccctcgggg ccgagcccga acccggtcac cacgacaccc gagaggaggt gaaacgcatg
    12721 gccatctacg acctccaggg cctgggcgcc gaaacgagcg ccgaattggg ggacctgagc
    12781 aacagcaacg ccaccagcgt gttctgctgc gtcccgtccc cgaacctcag cagcttgtcg
    12841 atcacctgcc gcgactgctg agctgaaccg gcaccgcgaa gggccggttg ctccggatca
    12901 cctccggggc agtcggcccc ctctccaccg gaaggcggaa gcccatgccg cagcggagac
    12961 tgctcggcgt cctgcgaccc caccgagccc gcgtcgcact cctgctcgtc ctgatcgtgg
    13021 ccctggccgc gaccaccgtc gccccggccg tggtcgcgca acgcctcatc gaccacggtg
    13081 tgctgcgccg cgacgaaggc atggtgtggg ccatgactgg tgctctggcc gcgctcggcg
    13141 ccgcccaggc cgccctgacc tacctggagc ggcggttcgc cacccgcctc gccgaggacg
    13201 tcgtcctgcg cctgcgcacc gacgtcttcg cgcatctgca acggcagtcc ctcggattct
    13261 tctccgtggc caggaccggc gccctcgtct cccggctgca cggcgacgtt gcgggcgtac
    13321 agcaagtggt cgcgggcacg ctgcccgccg ccgtctccgc actgttcctg ctcctcacca
    13381 cgggcctgac cgtgacggtg atggagtggc ggctcgccgg gctcgtgctg ctcctgatcc
    13441 cgctgctcta cctgctcacg tcccacttca cgatcgcgct gcgcaaggtc aaccaacgga
    13501 tgctcggggc cttcgccgac ctcgactcgc tggtcgccga acggctcagc tccggcggcg
    13561 ccgaggtgat ccgccactac ggccaccccg accgggacgc accgcgattc cggctcctcg
    13621 cagcccgggt gcgcgacaca tcggtacgcc gcgcctcgct cgctgccgcg ctcaccggct
    13681 ccctcgtcct catggtcagc ctggtcaccg cgttgatcta cctcgtcgcg agccgcctcg
    13741 cgatatccgg aaccctcacg ctgggcacgg tcatcgccct gctgtcgttg ctggcgcggc
    13801 tgttcgggcc gctgaccgca ctgcccgggc tccgcgtgga actgatcgcg ggccgggtcg
    13861 cattcgaccg gatccaggaa gtgctggagt tcgagccgca gatcgtcgac gcccccgatg
    13921 cccgtccttt gcccgtacgc gcggaccggg cgccctccgt ggagttccgg cacgtcgact
    13981 tcgcctatcc accgccccac gacctggccg tcccctcact caccggggac caggacgccg
    14041 acctcgccga cgaagccgac ggtcacctcg acgaggagct gttcgacggc gacccgacca
    14101 ccgacgccca cggtccgcgg gccgccctca ccgccctcag cttcatcgcg gcacccggca
    14161 ccaccgtggg catcgtcggg ctctccggag cgggcaagtc caccctgacc cgcctgctca
    14221 cgcgctcctt cgacgtgggc gcgggccgcg tgctgatcga cggcgtggac atccggcgcc
    14281 tgcgtctgga cgacctgcgt tccgcgatcg gcatcgtgcc gcaggagacc ttcctcttca
    14341 acgacaccgt ccgggccaac ctcctcctcg cccgcccggc cgccacgacc gaggaactgg
    14401 aggccgcctg ccgcgacgcg cgtgtctgga gcaccgtcga gaaactcccc gacggcctcg
    14461 acaccctcat cggtgatcgc ggactgcgcc tctccggcgg cgaacgccaa cgcctggccc
    14521 tcgcccggct ggtcctcaag ggcccgccga tcgtcgtcct cgacgaggcc acctcgcact
    14581 ccgacaccgt caccgaacag gagatccagg agtccatggg cgagttcctg cgctcccgca
    14641 cctgtctggt catagcccac cgcctgagca ccgtccgcga cgccgaccag atcctcgtga
    14701 tgcgagaggg ccgcgtcgtc gaacgcggcc cccaccagga actcctcggc gccggaggct
    14761 ggtacgcgcg gctgcaccgg gcacagcaca gggtgccggt ggcacgctga cgcgacgcgg
    14821 tccgacgggc gggacggtgc cgccgccgtg accgacagca tcctcgcccg tcggaagcga
    14881 accgaccagg tactgctccg ccgggcgaac ctcagctctt gacggcatcc gcgatctgct
    14941 gggcggcctg gtcgggcgtg aggtgcgtgg tgtcgacgac ctcggccgct tcgtgcagcc
    15001 acgcgcgggc tgcctcggcg tagggctcga ggtgttggag ccggaacggg gagtcggggc
    15061 cgagaacggt gtcgcccgcg atgcgcgcgc ggagggtgtc ctggtcggcg tggaggacga
    15121 agtgccgtac cggaacggcg tgtcgggcga ggccggtgct gatctcgcgc cagtactcct
    15181 cgaccaggac cgtcatgggc atcaccaggg tcccgccggt gtagtcgagc acgtggcggg
    15241 cggtctcgac gacgagcggt cgccacggcg gccagtgctg gaagttgccc gtccacggca
    15301 gcgtcggtgt gatgtccatg agggtctcgc cgaccttctc ggcgtcgaac acccgtgaat
    15361 cagggatcag cttctgcacg agcgcgctcg tcgttgtctt gcccgcaccg tgggtgccgt
    15421 tgagccatac gatcatggga ccgacgctac cgctgtgcgg gtcgcgggaa cggacacgac
    15481 ccggtggctg attcacggtt ggcttgatcc atggccgagg tcggcgtcgg ccgttggtga
    15541 cgggctcggg tggtgctgct ctgcatgcgc gctttcgctt ccgtgtgttg ggcggctgcg
    15601 atcacgcagg cggcgcgcac gaaggcggcg acagccggtg agcgcgcgtc ctggggccag
    15661 gcgacgagca gtctggcgtg cggcaggtcg ctgaccggac gataggcgac atccggccgc
    15721 ccggaggggc gggcggaccg aacacggccc ggcccgcccc tccggggcgt ttgttcgcta
    15781 tggaaggctg tgcaccttcg ggccgaccgc gttcgaccac gcgtggcccg ccgtcgcgtc
    15841 ccagttcgtc gaccacgtca tggcgccgcg gagcgacggg tacgtcttcg acggcttgaa
    15901 ggagccgcag ccggtgccgc gggtcaggca gtcgagggcg ttgttcacga tcgacggggc
    15961 gacgtaaccg ctgcccgcgc cgcgcgtcga cgccgggacg ccgatcccga cctgcgacgg
    16021 gtcgaggccg ccctccaact ggatgcaggc gagcgcggtc aggaagtcca cgctgccctg
    16081 gctgtagacc ttgccgtcac agccgagcat cgaaccgctg ttgtagtact gcatgttgac
    16141 gacggtgagg atgtccttca cgttcagcgc cgtctggaag tacccaccgg acgtcgactg
    16201 catgtcgatg gtctgcgggg ccatcgtgag caccatcttc ggacccgcct tggccgagag
    16261 ctggcgcagc gccttcgtca tgtaggtggg gttgatgccg ttctccaggt cgatgtcgac
    16321 accgttgaac ccgtactcct gcatcagcgc gtaggcgctg ttggcgaacg cggtcgcgga
    16381 ggcgtcactg ttgacggaga tggtgccctt ctcgccgccg acggagagga tcacggactt
    16441 gcccgcggcc ttcttcgcgg cgatgtccgc cttgaagtcg gcggtggagg cgtagccgac
    16501 ggccgggtcc aggttgaagg tgatctgccc cggagtgggg gtggcgtcgg cgaacgacac
    16561 ggcgatgatg tcgtactgcg aggacacgtc ccgcagcttc tgcacggtcg cgccgttgtt
    16621 gaagttctgc cagtagccgg tcaccgcgtg ccggggcacc gtgccgtcac cgccaccgtc
    16681 acccttgggg gtcgtcacgg acaccgccgt cgacttcgcc gactcgcccg ccgcgttcga
    16741 tgcgctcacc tggaagctgt acgtggtctc cggcgtgagg ccggtgacgg tcgtggaggc
    16801 gccactggac gaggcgacct tcgtgccgtc gcggtagacg gtgtagcccg tcgccgtgga
    16861 cgacggcgtc caggacagct ccaccgacgt gggtgtcgcc gtgcccgccg cgagtccggc
    16921 cgggacgggc ggtatctcga ccgggtcggg gccaccgccc ccgtcgggtc cgaagacgct
    16981 cacgtcgtcc acgtagtacg cgctctgccc gtaccagccg tgggtgtaca cggtgaccga
    17041 ggtggtgttc gcgccggtgg tgaagctggt ggagagctgc tgccaggacg aggtgcccgg
    17101 cgtccaggtc gacacgtcgg tggtgccggt gccgcgcgcg ccgaggtagg cgtagctgcc
    17161 ctgcacccaa ctgctcagct tgtacgtcga gttcggcttc accgcgacga tctgggaaca
    17221 ctcggcggtg ccctgcccgg acggtgtggc cttgagcgcc ttcgcgccgc cgtgcacggg
    17281 ggacgtgacg gcggcaccgc tgttcgcggc gcaggtccag ttgttcaggt ccgcctcgaa
    17341 cccggcgttc ttggcgacgt tgacgtccgc tgctctggtg ctcgccgcct tggtgccggc
    17401 cgtgttggtg tcggccgact gcgcgggcgc ggcgagcgcg gtgacggcga gcgcggtggc
    17461 cgcaccgacg gccatcaccg cgctgattct ccggcggacg ccgggtctgt ccttgcgcac
    17521 acggtccacg ggtgcctcct gggagagagg tgaagcacgt gagcgacgac ggtggccatc
    17581 gctgttgcgc gcaaagttgg tccagaccaa tagagttgtc aagacctctg gagaggagaa
    17641 cctgcagcgg agcggtcgac ggccgtggtc gccgccaacg ttatgactcg ccggtgatcc
    17701 tggccgagcc gatcgtcgcc gcgatgatct ccctggcagc ggtgcgggtc gacgagttgg
    17761 agttgaggct gctcaacgac ggctggttga gcgcgtggac gacgaactcg taggtgttca
    17821 ccgtcgaggg ggagcacggt ccctggtagc cgtagaggct cgcgctgcct cggtagtaga
    17881 cctgcctggc tcccgccggg gtcgagggcc ggtaggcatg gtcgacgttc tgggggagtg
    17941 aggtcgcgct cgccgggatg tcgtagatga cccagtggat gaggttggag ttgtcgagat
    18001 cacgcatgac gatcgcgtag ctcttggcgg cggtcggcgc gcccgcccag gtcaagggag
    18061 gagattcgtt cctcttgccg gggtcgctcc ctccgccgct ggtgcactcg tggactttgg
    18121 ggatgacgcc gccgtcggcg aacgcggtgc tggacagggt gaaggcgctc cggttcgccg
    18181 gcggcgtgga tggcggtgat ggcgtcgacg aggtcgccga ggcggtggtc ggtgagaggc
    18241 cgacggcccc ggtgatgagc agagcgcaaa gcgcaattcg tgcacttctc actggacgct
    18301 cccgaagaaa tgtgtggtcg cttaggtgtc cgtggcgcgt gagtggtatt cgtgcgatgc
    18361 ggtcaacgta tgcgtcgtgg attctgatgt catgtcactt gtcgacctga tcgatgtact
    18421 tttctcgcct tcggtttgct gtttcggacg ggcgaattga agccgacggg tcgaccggcc
    18481 gcgtagccga cgacggcttc ccggccgggt tccgggctgt ggccggaccg ccgccggtgc
    18541 gcccgcgcac caaggtgtcg ccgagtcggg tggcgccgtg aaggaggtgc tccagcgggc
    18601 cgcgccggaa gaaccgcgac cacacggtgg cgagcagcac cgcggcggcg atgaaggcgg
    18661 gcagcaggag caggggcagc ccgtcgaggt cctcgatgcc cagcgcccag atcagcacga
    18721 tgtgcaggac gtaggccgtc agggacatgg agcccacggc gatcacgggc cgggcccacc
    18781 tcgtgagacg cggcagccgg tcgagggcaa agacgcacgc ggtcagcacc agcagcgcga
    18841 cgccggtgtt ggcgacgatg gacagcgtgg tctcgctgtg cggcgcggcg acccacagcc
    18901 aggcggtgcc cgacgtctcc gacacaccgg ccacgtcgga ccaccacgac gccatcacgg
    18961 gcccgtccca ggcggcgtcc gccgcgagcg cggcaggcac gccgggcagc aggtgcagcg
    19021 cgagccagga gccgccgtgt ccgacgacgg cgagcgcggc cccggtggcg gcgagccggg
    19081 cccgtaccac gcgggaggcc aggtcgagac gggccacggc catgcccgcg agaaggaacg
    19141 acagccaggc cagggccggg tagctgccgg tgacgagcag gtccaggaag ccgtccgtgt
    19201 cactgacgcg ggccaggggg tcgtgggcga tcaccgtttc gccccaggcg ccgtcgtcga
    19261 gggagcgcag cagcagatgg cggacttggg gcagggtgag ggcggtgacg gcggcgagga
    19321 ccgccagagt gcggggacgc agtcggtaca gcggcaggag cagggcgaag aacagcccgt
    19381 agtaggccag gatcacctcg accggcgtgc cggtcatcgt cagcgcggtg ccgagggcga
    19441 ggaggaccac ggcacgtatc agcacgtgca gcacggcctg gcggccggcg cttccggtcc
    19501 gcggctcgct gcgcccggtc aggaggatga gcgagaagcc ggcgaggaag gcgaacaggg
    19561 ccgaggagcg gccgtgggac agctccagga agaagccggt gacgccaccg gcgtcctcgg
    19621 gggcggggcc gacgtgggcg gcgtacatgc cgaagaccgc caggccgcgg gctaggtcca
    19681 cgccgagcag ccgaccggtc gtggcaaggc cgtcacggtg ggcaagggcg ggagcgtcgg
    19741 tcgccacagg cgccgtcacg gacttccgtg gctgcaatct catgccagtc agactcgaag
    19801 aagcgcaggt caacttgtat ccgtcgagct gctgccggac ccccgccacc cggcgggaac
    19861 ccacccccca gccagcgggt gcggcggtgc cgcttgcggc gtcgagccgg tgcgcgatta
    19921 cgctccgttc agcaagcgca tgcgtacgac gacgggcagc gggacggggc agatgtgatc
    19981 cgggtagtgg tggtggacga cgaggcgctg gtccgctcgg gcttcgagct gattctcagc
    20041 gcggcggacg acatcgacgt cgtcgccacc gcgaccggcg ctgaggccgt cgagaccatc
    20101 gtccgggtac ggcccgacgt cgtgctcctc gacatccgca tgcccgacac cgacggcctg
    20161 accgtgctgc gggaactacg cgccctcgac gccccgcccg tcgcggccat gctcaccacc
    20221 ttcgactccg acgagtacat cctgaccgcg ctgcgctccg gcgccgccgg gttcatcctc
    20281 aaggacaccg cacccgaaca actcgcccac ctggtccgca cgctggacgc cgggggagtg
    20341 gtcctctcac ccaaggcctc atccgcgatc gtcgacggcg cgcacggcgt cgccgaggac
    20401 gatccacagg tacgacgggt gagactgctg accgaccgcg agcgcacggt cctcaggctc
    20461 atcgccgaag gcctgtcgaa cgccgacatc gccgcccgcc tgcacctgag ccccggcacc
    20521 gtcaaggacc acgccagctc gatcctcggc aagctgcggg tgtcgggccg cgtacaggcg
    20581 gcgctcctcg cccaacgcgc cggcctgctc acggccaagg gcaccgaacg acaccacccc
    20641 tcccacgaca cgggcccacg accatgaacc agccgcacca gcggacgccg tcccgcaccg
    20701 aggacgcccg ccgactcgcc gcgacctggg caacccccat gatcgtgctg ctcgcggcgg
    20761 ccgacctgtg gtggaacgcc gaggacgtca agacgtacga ggtcacctgg gccgcagcgg
    20821 cctgcgcggc gctggcgctg cgcagccgct tcccgctgac ggtgttcctc atcggagtgc
    20881 ccgccacctt gttcaccccc ctcatggtgg tgccgttcgc gagcctgtac gccctggccg
    20941 cggcgtcccg caaccgtccg ctcctcgccg tgtgcgcact ggtctcggcg gccgccgacg
    21001 ccgcgccctg gccactgggc gactacgccc acgacggcgc gacccgcacc ctcgtcgact
    21061 tcgcctacct catcgccacc gccgccgccc ccgtcttcct cggccagctc gtccaggccc
    21121 gccaggacgc ggcggagcgc ctgctcgagg tggaggaggc ccgggaccac gagaggcagc
    21181 tccacgccca gaacctgctg gcccgtgagc gcgcccaact cgcccgggag atgcacgacg
    21241 tggtgtccca ccaggtgagc ctgatcgccg tccaggccgg tgccctgcag gtcagcacca
    21301 ccgagcccag ggcgaaagcc gcggcccaca ccatccggga gctgagcgtg accaccctgg
    21361 acgagctgcg gcacatggtg acgctcctgc gcatgtccgg cggaggcgcc tccgagctcg
    21421 caccccagcc caccctggcc gacctgcgcc ggctcgtgga cggcagcggc atacacagca
    21481 ccctcaccgg cgaactgccg gccgacctgc ccgcgcccgt gcaacgcacc ttgtaccgca
    21541 cggtgcagga agcactcacc aacgcccgca aacacgcccc cggctcccgc gtcaccgtcc
    21601 acctgtggca cgacctggac cacatcggcg tcaccgtcac caacacgccg ccctcccggc
    21661 ccgccacccc tctgcccggc gcccacctcg gactcatcgg gctgcgcgaa cgagccgacc
    21721 tcctgcacgg acacttcgac tccggcccca ccaccgaggg cggattcacc gttagcctca
    21781 ccctcccgta cgccccggaa gcacagccct ccggccgacg cgagtcgcac ccgcgcgact
    21841 gagcccattg accctggcgc gtccggggcc ccgccggacc gaccgggcga tgcggagtgc
    21901 ggtccgcctc agtggccggg cgggatccgg tcccgcggcc cgtcagccac ctccgccgcg
    21961 ccgccgtcca gctgcgcctg ctcggcgacg gccgggtcgg cggagtccga gaccaactcc
    22021 gcgacgcgca gggtgcactc ccactgcgtc agcttgcctt tgatcgccac caggtacgtc
    22081 tcctggtcgg cgaagcggta cacgcgacgc cgcttctcga caagactctt gctcggtacg
    22141 tacgtgaaga gggccgcacg aagtgcctcc agcgcctgga gcttcgtctc cagcccagca
    22201 cggacgaact cggtcctgta cacgtcgctg tggtactgcg cgatcacgac ccagttgccc
    22261 atcactcctc ctcggtgccg ctgccagtcg gccacagctc ggcctccgga gcaagagcga
    22321 ggcatatcct gagcggtacg gctgcacgcg cccgcgcctg gcttccacgc tatcggccca
    22381 cctggacccg gaaggagagc cggtcgccct gcgtctggac tgccgcgctc tgcagggtcg
    22441 gctctttgta cgaccgtgcc cgctcgatca ggatggggca gccgtgctcg tcgtcgaggc
    22501 agccgccgcg ttcggccccg agggtgtcga cccgggctac gcccgcctga cgcttcatcc
    22561 actcttcgac caggaggact tggtcggcgc actgtttgac gcacgggtcg ggccacgtgt
    22621 acgtcacttg cgcctggttc tggtcgacgc gggtcgtggt cggcggggag aagccggtgg
    22681 gggtggtgag ggcgtcggcc acggcccggt tg
//
