LOCUS       NZ_RHGC01000002        22868 bp    DNA     linear   CON 30-MAR-2024
DEFINITION  Streptomyces alboflavus strain 313 contig002, whole genome shotgun
            sequence.
ACCESSION   NZ_RHGC01000002
VERSION     NZ_RHGC01000002.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces alboflavus
  ORGANISM  Streptomyces alboflavus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 1226588)
  AUTHORS   Guo,Z., Li,P., Chen,G., Li,C., Cao,Z., Zhang,Y., Ren,J., Xiang,H.,
            Lin,S., Ju,J. and Chen,Y.
  TITLE     Design and Biosynthesis of Dimeric Alboflavusins with Biaryl
            Linkages via Regiospecific C-C Bond Coupling
  JOURNAL   J Am Chem Soc 140 (51), 18009-18015 (2018)
   PUBMED   30516971
REFERENCE   2  (bases 1 to 1226588)
  AUTHORS   Guo,Z., Li,P. and Chen,Y.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-OCT-2018) State Key Laboratory of Microbial Resources,
            The institute of Microbiology, Chinese Academy of Sciences, No. 1
            Beichen West Road, Beijing 100101, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: No
            Genome Coverage                   :: 10x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003935055.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 13:06:06
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,631
            CDSs (total)                      :: 7,558
            Genes (coding)                    :: 7,426
            CDSs (with protein)               :: 7,426
            Genes (RNA)                       :: 73
            rRNAs                             :: 2, 3, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 3 (5S, 16S)
            partial rRNAs                     :: 1 (23S)
            tRNAs                             :: 64
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 132
            CDSs (without protein)            :: 132
            Pseudo Genes (ambiguous residues) :: 0 of 132
            Pseudo Genes (frameshifted)       :: 40 of 132
            Pseudo Genes (incomplete)         :: 103 of 132
            Pseudo Genes (internal stop)      :: 12 of 132
            Pseudo Genes (multiple problems)  :: 20 of 132
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 15:58:57
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 650115
            Orig. end                         :: 672983
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            RHGC01000002.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22868
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="3"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22868
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22868
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12868](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12868)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    1173..1182
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.85"
                     /tool="antismash"
     gene            1234..1899
                     /locus_tag="EJ355_RS10000"
     CDS             1234..1899
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LmbU"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455667.1"
                     /locus_tag="EJ355_RS10000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LmbU family transcriptional regulator"
                     /protein_id="WP_193560624.1"
                     /sec_met_domain="LmbU (E-value: 3.1e-76, bitscore: 251.5,
                     seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPNLRHPTPNISGPQEKLTVDDRARTRRSSLSLPDYLPLEHWKTI
                     GEQIFAIVDSSAWWLGDWLVFGQQTYPRRYRDAIEQTSLDYQTLRNYAWIARKFPPSRR
                     RDGLSLQHHAEVAALPAPAQDHWLSLAEAHGWSRNELRRHLRAARTESQDAGATEDVQV
                     TASAEQCDRWEKAAQHMESDLNDWMIRKVDEAAATALGPEIADDAARSPHPDSSVASE"
     misc_feature    1285..1287
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2043..3218
                     /locus_tag="EJ355_RS10005"
     CDS             2043..3218
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006346919.1"
                     /locus_tag="EJ355_RS10005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_240044823.1"
                     /transl_table=11
                     /translation="MDFGEQPISDCFLPPESTDPEHFYRLVVGACESCTMVQLLHEVPR
                     ERMFHDHYPYHSSGSARMREHFRGVAERFVGTELTGDDAFIVELGCNDGVMLATVAEAG
                     IRHLGVEPSGSVADVTAARGIRVRKDFFEEETARAIRADDGQAAVIYAANTLCHIPYMG
                     SVLRGVLELLTADGVFVFEDPYFADIVRQTSFDQMYDEHFYYFTARSVAEMARRHGLDL
                     VDVERLAVHGGEVRYTLARAGARERTAAVGELLAEEEAAELTARHTLEGFRDRVLKARD
                     DLVSLLRELRSEGKDVVGYGATAKSATVLNYCGIGPELIAYVTDTTPAKQGRLTPGSHI
                     PVVPHQRFADDRPPYAVLFAWNHAEEIMAKEQEFRDAGGRWIRYVPGVRVD"
     gene            complement(3254..4570)
                     /locus_tag="EJ355_RS10010"
     CDS             complement(3254..4570)
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (101-435). E-value:
                     3.3e-52. Score: 169.7. Matches aSDomain:
                     nrpspksdomains_EJ355_RS10010_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF005589.0"
                     /locus_tag="EJ355_RS10010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_125262546.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.2e-43, bitscore:
                     144.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="t2fas (E-value: 8e-138, bitscore: 455.5,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSASGHEHRIPGSGSGPGPGPGQETHPAPDRVVVTGRGVVSPLA
                     PNWPDTWAALVAGKSGIRDITGFEVGDLPVRIGGEVPGFEPEHHLPRHVVRRTDWTIQV
                     VVAAARMALQEAGIEIDEVLAPRVGVAVGSIIGSTRVASRNAMAMRDEGYAAVSPQVFP
                     TMGISSAAEVCLELGARGPSAEMVAACATGTVCVGEAARWIREGRADVVVAGGMDAFDR
                     LELAAAARARVLSRRTGDPTTASRPFDKDRDGFVMGAGAGVLVLESAAHARRRGAEVHA
                     ELAGYASTTDAHHLTAPSPDGAQAERAMRTALEAARATPADVGYVNAHGTGTRLNDTTE
                     LTAIRRVYGDHAHRVPVSSTKSMTGHMLAAGGAVEAAVVTEAIRTGVVPPTLNCDSPED
                     PAMNFVAHQAQEHDVTVGVSHSFGFGGHNAVLVLRRWRG"
     aSDomain        complement(3266..4267)
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS10010_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.30E-52"
                     /label="EJ355_RS10010_PKS_KS.1"
                     /locus_tag="EJ355_RS10010"
                     /protein_end="435"
                     /protein_start="101"
                     /score="169.7"
                     /tool="antismash"
                     /translation="IQVVVAAARMALQEAGIEIDEVLAPRVGVAVGSIIGSTRVASRNA
                     MAMRDEGYAAVSPQVFPTMGISSAAEVCLELGARGPSAEMVAACATGTVCVGEAARWIR
                     EGRADVVVAGGMDAFDRLELAAAARARVLSRRTGDPTTASRPFDKDRDGFVMGAGAGVL
                     VLESAAHARRRGAEVHAELAGYASTTDAHHLTAPSPDGAQAERAMRTALEAARATPADV
                     GYVNAHGTGTRLNDTTELTAIRRVYGDHAHRVPVSSTKSMTGHMLAAGGAVEAAVVTEA
                     IRTGVVPPTLNCDSPEDPAMNFVAHQAQEHDVTVGVSHSFGFGGHNAVLVLRR"
     CDS_motif       complement(3551..3598)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10010_0002"
                     /evalue="3.90E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="EJ355_RS10010"
                     /protein_end="340"
                     /protein_start="324"
                     /score="10.0"
                     /tool="antismash"
                     /translation="YVNAHGTGTRLNDTTE"
     CDS_motif       complement(3986..4012)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10010_0001"
                     /evalue="9.90E+01"
                     /label="PKSI-KS_m5"
                     /locus_tag="EJ355_RS10010"
                     /protein_end="195"
                     /protein_start="186"
                     /score="-2.9"
                     /tool="antismash"
                     /translation="VAACATGTV"
     gene            complement(4567..5913)
                     /locus_tag="EJ355_RS10015"
     CDS             complement(4567..5913)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04516.1"
                     /locus_tag="EJ355_RS10015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_125262547.1"
                     /sec_met_domain="MGT (E-value: 1e-115, bitscore: 383.0,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRVLFVLYAEKTHLFIQVPLARAFAAAGHEVRVASQPELVPEIT
                     RAGLTAVPVGRDHGMGRLLALRPEFRSRFGGSDLPPFDVADVPGELLSLDYLRAGYGDV
                     VPWWFRLVNEPLVDELVGLCRWWEPELVVWEPGTFAGGVAARVCGAAHGRLTWGVDFFG
                     RVREQFVRLAAEEAAAGGTGGDPLGEWLGTLAGRYGVEFDEELTTGQFTADLLPAPFRF
                     DTATDYVPVRYGTYNGVSVVPRWLWEVPVRPRVGFTLGLSAVERLAGYAVSVVEILKAL
                     AALDVEVVAALPGAAGIREQLGAVVGDRVRVEEFVPLAALAPTCAVMVHHGGFGTIGTT
                     SLHAVPQLSLAEQLDAIWLARGVSSYGAGIDLQVAEATGERVAHEVQRLLTDPSFAEGA
                     QRLRADLHAMPSPAEAVPELLRLAERHRRPPLAAAPHPQAKNTGRQTTA"
     gene            complement(5910..6158)
                     /locus_tag="EJ355_RS10020"
     CDS             complement(5910..6158)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS10020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_100112313.1"
                     /transl_table=11
                     /translation="MDRAGVRKEIQTFMDQYYAREDGAGDGAEMYDIDSFTMVQLVLYL
                     EDKFNIVILEELHGFSGGDFDAFADFVAAAGQENDAA"
     gene            complement(6229..7239)
                     /gene="rfbB"
                     /locus_tag="EJ355_RS10025"
     CDS             complement(6229..7239)
                     /EC_number="4.2.1.46"
                     /GO_function="GO:0008460 - dTDP-glucose 4,6-dehydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (4-227). E-value: 3.2e-18.
                     Score: 57.7. Matches aSDomain:
                     nrpspksdomains_EJ355_RS10025_NAD_binding_4.1"
                     /codon_start=1
                     /gene="rfbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018542699.1"
                     /locus_tag="EJ355_RS10025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="WP_087887006.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.1e-18, bitscore:
                     62.4, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.4e-18,
                     bitscore: 60.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 5.5e-17, bitscore:
                     57.7, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVTGGAGFIGSNFVRRMLAGAYAGFEDAEVVVLDKLTYAGNQ
                     SNLAGALDDPRLRFVQADICDRDAVARAIKGVRTVVHFAAESHVDRSLLDGDAFVASNI
                     VGSYELLRAALRTEVDRFVLVSTDEVYGETETASWTEDFPLRPNSPYSASKASAELLAR
                     SFHRTYGLPVCTARASNTYGPYQFPEKLIPLFVTRLLDGLTVPLYGDGSQVREWIHVDD
                     HCRGLALIAGAGRPGETYNIGGGTEISNAELTKLLLEFLDADWSQVRFTEDRKGHDRRY
                     SIDCRKIREELGHRPLVAFREGLLDTVRWYADNRNWWEPLKRPGELPLAAMAEPH"
     aSDomain        complement(6559..7227)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS10025_NAD_binding_4.1"
                     /evalue="3.20E-18"
                     /label="EJ355_RS10025_NAD_binding_4.1"
                     /locus_tag="EJ355_RS10025"
                     /protein_end="227"
                     /protein_start="4"
                     /score="57.7"
                     /tool="antismash"
                     /translation="VTGGAGFIGSNFVRRMLAGAYAGFEDAEVVVLDKLTYAGNQSNLA
                     GALDDPRLRFVQADICDRDAVARAIKGVRTVVHFAAESHVDRSLLDGDAFVASNIVGSY
                     ELLRAALRTEVDRFVLVSTDEVYGETETASWTEDFPLRPNSPYSASKASAELLARSFHR
                     TYGLPVCTARASNTYGPYQFPEKLIPLFVTRLLDGLTVPLYGDGSQVREWIHVDDHCRG
                     L"
     gene            complement(7271..8143)
                     /gene="rfbA"
                     /locus_tag="EJ355_RS10030"
     CDS             complement(7271..8143)
                     /EC_number="2.7.7.24"
                     /GO_function="GO:0008879 - glucose-1-phosphate
                     thymidylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009243 - O antigen biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0019305 - dTDP-rhamnose biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="rfbA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330874.1"
                     /locus_tag="EJ355_RS10030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glucose-1-phosphate thymidylyltransferase RfbA"
                     /protein_id="WP_087887007.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.1e-12, bitscore:
                     44.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGTGSRLMPITAGTSKQLLPIYDKPMIFYPLSVLMLAG
                     IRDVLIIAAPESMPSMRGLLGDGAHLGMNLTYAQQPEPRGIADAYIIGADHVGNDRSAL
                     ILGDNLFHGAGFQDLLREAREKSDGCTLFGYPVADPERYAVAETDAHGNLIGIEEKPAC
                     PASKNAITGLYFYDSDVVEMARGLRPSHRGELEITDVNKLYLDAHAARLVQLGRGFTWL
                     DAGTFRSLLDASQYVQVLMDRQGVRVACLEEIALRMGFIDAGQCHELGLAMGDSGYGRY
                     VREVAEALA"
     gene            8230..9510
                     /locus_tag="EJ355_RS10035"
     CDS             8230..9510
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04516.1"
                     /locus_tag="EJ355_RS10035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="activator-dependent family glycosyltransferase"
                     /protein_id="WP_205048928.1"
                     /sec_met_domain="MGT (E-value: 1.1e-118, bitscore: 392.7,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMRILFTAYAVRTHFFSMVSLAHALDTAGHEVRVASQPELVPEI
                     TRAGLTAVPVGRDHQLWRVLKARHGDERWSALPPFDVADVPGELLSLDYLRAGYGDVVP
                     WWFRLVNEPLVDELVGLCRWWEPELVVWEPGTFAGGVAARVCGAAHGRLTWGVDFFGRV
                     REQFVRLAGEAGEPVGGAGDPLGAWLSDLGGRYGVAYDEELTTGQFTVDQLPEAFRLET
                     GIEYLPMRFGVYNGVSVVPRWLWEVPVRPRAGFTLGLSAVERLAGYAVSVVEILKALAA
                     LDVEVVAALPGAAEIREELGAVGDRVRVEEFVPLAALAPTCAVMVHHGGFGTIGTTSLH
                     AVPQLAVAEEIDAPILARGLAAYGAGVDLPVAEATGERVAHEVRRLLTESSFTEGARRL
                     RADMRAMPSAADVVPELVRIAERHRGR"
     gene            complement(10001..12868)
                     /locus_tag="EJ355_RS10040"
     CDS             complement(10001..12868)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS10040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="protein kinase/lanthionine synthetase C family
                     protein"
                     /protein_id="WP_125262548.1"
                     /sec_met_domain="micKC (E-value: 2.3e-128, bitscore: 425.4,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-05, bitscore:
                     19.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDWSIYTLVDPVFFETPARAAAEEHLVPSRFAPLPDGWRHRAARV
                     WDMYQPDEPHTPDQGWKIHVSATHDNAAQVLEIVADHCLRARVPFKHLRGRAVLDAMNS
                     KYAPRPAGGKFIAVYPRDEAEFADCARELDERLAGSDAPYILTDCRWGEGPVHFRYGAF
                     RERWCWTDDGAHVLALTDSDGRLVPDRRRPAFALPEGVPVPDALRPHIERRTAASGEFG
                     YRVKEALHFSNAGGVYAATRRDDGSPVVLKEARPHTGRDGAGLDATARLAHEKRVLDRL
                     ADVPGVPRAYELFDFGGHSMLAMEHLDGIPLQRWMVRHHPLINWNACTPDGLRAYARRA
                     EALHAEVAALVRRVHAEGIVFGDLHPGNVLVAEDAFGPEGDAFGPTEEAFGPGVHAEPG
                     EHAGPGERAASGGSPTPPDTAPKVRLVDFEMAFPTSENTRPTLGYPGFAARRKTGPAVD
                     EHALTVLRLWLYLPLVTSLGICPDMGARLAAAAAQRFGLPDDFAATIAAGLAEAPDAQA
                     PQPAEHARDTAGRAARPGTPPPIGAVADVRLDTSPVDWAAVRASLARALHASATPDRDD
                     RLFPGDPRQFNEAPGGFAHGAAGVLWALSVAGGERGTPYEDWLLRAARADHVRPGFHDG
                     AHGVAHVLDRLGHHAAARELIDRARAGVEEMTDVSLYGGLAGVGLNLLHFVGDDPGHAW
                     LKEARELAARAVDALDDGRPHGIDRARGEPGTHGGLLRGWSGVGLFLLRTYEATGEDAY
                     LRHAVRAVHRDLDLCVLREEGVLHVDGGFRSLPYLETGSVGIGLVADLLTDHTDDPRIA
                     EALPALALAARSPLTVESQLFNGRAGLLAAAHALRRHLPATASEGAEAGADPVAEHLGS
                     LHWHALAHRGEVAFPGHSGLRLSMDLATGNAGVLAALSYVTDGGPPPLPFLGRAGRAAA
                     GADHGLPADDRRRIPCDRPVGGDTA"
     misc_feature    complement(12897..12911)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: strong, score: 20.64"
                     /tool="antismash"
     gene            complement(13076..13771)
                     /locus_tag="EJ355_RS10045"
     CDS             complement(13076..13771)
                     /EC_number="2.-.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024698.4"
                     /locus_tag="EJ355_RS10045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="GNAT family protein"
                     /protein_id="WP_087887012.1"
                     /transl_table=11
                     /translation="MTIETPKTSEAIRVGRRVELGYATADDYGQFAKWLSPDGDVAALT
                     GDVSERVTVDTLRADAASGSRFCTMRSLDGERVGMVKFHRVGGERDTTFEISGAIGSSD
                     LWSRGYGAEGFGLVVEHLFEDLGAHRLQFWVGLFNEPMLQMVMRTRFFVLEGVLRERKF
                     FKGEYHDVAMWSMLRHEYEALFVRGEWEQKPGQDAWFDTASEPKAAARRTLAEYLGRGP
                     ATALTPFTR"
     gene            14002..14781
                     /locus_tag="EJ355_RS10050"
     CDS             14002..14781
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_043470770.1"
                     /locus_tag="EJ355_RS10050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TylF/MycF family methyltransferase"
                     /protein_id="WP_240044781.1"
                     /transl_table=11
                     /translation="MLTHSRDLYLDLMKKVVTNTIYQDNAHGWVRNKDFDAGLPSIEYD
                     DELRAGGRDIPRVAHTMIGGKRLDNVHACVEQVLSDDIPGDLIETGVWRGGATIFMRAV
                     LKAYDIKDRTVWVADSFEGIPKGDPVRYPGDDLAPLYRFNDVFGVSQAIVEENFRRYGL
                     LDDQVRFLPGYFRDTLPDAPVESLAVLRMDGDLFESTMDALVHLYPKLSVGGYVIVDDY
                     RALPPCRVAVYQYRREHGITDPIEEIDGVGVFWRRTR"
     gene            complement(14802..16577)
                     /locus_tag="EJ355_RS10055"
     CDS             complement(14802..16577)
                     /NRPS_PKS="Domain: CAL_domain (71-495). E-value: 5.9e-112.
                     Score: 366.4. Matches aSDomain:
                     nrpspksdomains_EJ355_RS10055_CAL_domain.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FAAL_cd05931"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="EJ355_RS10055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="fatty acyl-AMP ligase"
                     /protein_id="WP_125262550.1"
                     /sec_met_domain="FAAL_cd05931 (E-value: 4.1e-207, bitscore:
                     686.4, seeds: 56, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.4e-91, bitscore:
                     300.9, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTEAPRTAHTPTTDTGFTLSTLGPEPVGLEYLADTVRRLAAERG
                     DAPAVTVLGDRRVRGGARRTDTVVTLTYRELDERARAVAAELQAACPTRARVAVLCPHD
                     EHYVVAFLGCLYAGVIAVPLYAPELFRSQTRLRSVLRDSTPGCVLTTSQVRPAVRTALS
                     GTGWQQGPVLHVDEVPAHRASKWRRPPAAPDDVAYLQYTSGSTGAPAGVRVTHANLSAA
                     AYQMRSRFMPATTAVSWVPLFHDMGLVCAIASPLSAGMHMVHLSPMGFLHRPYRWLRAL
                     SDYRADWTVTPNFGLTHCVRRVTAEEVASLDLSGLRALAIGGEPVHARSVAEFVAAFAD
                     AGLDPRSPVPCYGLAEATLSVTMTPNGTGAVGAHFDRAALTAGEVRPVPDGPDSVHLVS
                     NGTPVPGVRVRIADPATGQETTGRVGEIWVGGPNRTDGYWRAPERTARVYADGWLRTGD
                     WGFVHDGGLYVVGRMDDVIIVRGRNHYPEDIEATVESVAPVAATAIGVEGDPTERLIVL
                     MEADAAMTALPEPDRDALTERIRQTVSRQHGLAVHATVVVRRGTLPRTTSGKIQRGLCR
                     QRYAAGAYAPPPRPT"
     aSDomain        complement(15093..16364)
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS10055_CAL_domain.1"
                     /evalue="5.90E-112"
                     /label="EJ355_RS10055_CAL_domain.1"
                     /locus_tag="EJ355_RS10055"
                     /protein_end="495"
                     /protein_start="71"
                     /score="366.4"
                     /specificity="Minowa: NH2"
                     /tool="antismash"
                     /translation="TYRELDERARAVAAELQAACPTRARVAVLCPHDEHYVVAFLGCLY
                     AGVIAVPLYAPELFRSQTRLRSVLRDSTPGCVLTTSQVRPAVRTALSGTGWQQGPVLHV
                     DEVPAHRASKWRRPPAAPDDVAYLQYTSGSTGAPAGVRVTHANLSAAAYQMRSRFMPAT
                     TAVSWVPLFHDMGLVCAIASPLSAGMHMVHLSPMGFLHRPYRWLRALSDYRADWTVTPN
                     FGLTHCVRRVTAEEVASLDLSGLRALAIGGEPVHARSVAEFVAAFADAGLDPRSPVPCY
                     GLAEATLSVTMTPNGTGAVGAHFDRAALTAGEVRPVPDGPDSVHLVSNGTPVPGVRVRI
                     ADPATGQETTGRVGEIWVGGPNRTDGYWRAPERTARVYADGWLRTGDWGFVHDGGLYVV
                     GRMDDVIIVRGRNHYPEDIEATVES"
     CDS_motif       complement(15108..15170)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10055_0003"
                     /evalue="2.80E-06"
                     /label="NRPS-A_a8"
                     /locus_tag="EJ355_RS10055"
                     /protein_end="490"
                     /protein_start="469"
                     /score="19.9"
                     /tool="antismash"
                     /translation="VGRMDDVIIVRGRNHYPEDIE"
     CDS_motif       complement(15237..15314)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10055_0002"
                     /evalue="4.10E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="EJ355_RS10055"
                     /protein_end="447"
                     /protein_start="421"
                     /score="28.7"
                     /tool="antismash"
                     /translation="GRVGEIWVGGPNRTDGYWRAPERTAR"
     CDS_motif       complement(15930..15989)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10055_0001"
                     /evalue="9.40E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="EJ355_RS10055"
                     /protein_end="216"
                     /protein_start="196"
                     /score="24.4"
                     /tool="antismash"
                     /translation="AYLQYTSGSTGAPAGVRVTH"
     gene            complement(16574..18460)
                     /locus_tag="EJ355_RS10060"
     CDS             complement(16574..18460)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018892716.1"
                     /locus_tag="EJ355_RS10060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_087887014.1"
                     /transl_table=11
                     /translation="MLGTAPDTARETDPPDEREPEERAESGRPAILRPDAWRDMLRYLR
                     PQRRLILLGGGLSLLGGFSGLIQPVIAKSVVENLESRSPVMAALIALTALVLVSAVVGA
                     IGTFILMRVSESVVLSTRREVIRRVLWLRVAETDKIPPGDLMSRATADTTLMRSAVTTA
                     IVETVNGSVMLVAILVLMGVMDWVLLLTTLAVVLLGGILVATGLPQLESAARRAQEGVA
                     ELSTALERALGTFRTIKASGAENSEAEIAERGARRAWRHSLKVARLDSLVGAFITVTIQ
                     VAFLAVLGVGGARVASGAMSLGSLIAFLLYLFYLVPPLGALVTAMIRFNVVAAAMSRVS
                     ELLRLRTEPESAPRPAPAPSDRAPAPASLSFHDVVFRYPGDGPVVHHGISFEIPAAGMT
                     AFVGPSGAGKSTVFSLIERFYEPQSGTVLLDGRDVHELDLGELRAAIGYVEQDAPVLAG
                     TIRDNLCIGMPYVEEDELRRVVDQARLGELVARLPHGLDTEVGHRGTKLSGGERQRVAV
                     ARALLRRPRLLLLDEVTSQLDARNENALREVITGITAETTVVVVAHRLSTVSMADRIVV
                     MDGGRIRAVGTHEELLSEDALYRELAATQMLLPVSELEASAARIGDTLGERP"
     gene            complement(18441..19976)
                     /locus_tag="EJ355_RS10065"
     CDS             complement(18441..19976)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012447.4"
                     /locus_tag="EJ355_RS10065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aromatic amino acid ammonia-lyase"
                     /protein_id="WP_087887015.1"
                     /transl_table=11
                     /translation="MITDVAESPKERLADIVRQARPDARVRPCSALEAERMRAGVDRLA
                     RALADREQVYGVTRGFGPLVEYAAAASDTDQGSGLIAHLGSGQGQPLSPEVCRLVLWIR
                     LNSMRLGHSAVSPEFWDRVAELWNQGFTPVIPRDGTVSASGDLQPLAHAALALAGEGEA
                     WLRDGSGQWRVRPSAEALAALGARPVTWRARQALSFVNGTSVSLAVTLLNHREVLRLSR
                     AVAALTARAVTLLGASPQAYHPGVGHARGQAGQLVAARWIREDLPPDHRRDPARPLQEP
                     YSLRCAPQVIGAVVDQLSVLEDILVREAVGCTDNPVYYEGEFLHAGNFHAMPVGLASDQ
                     IGLCLQQIAFLAERQLALLCLPETNGGKPPMLTPVPGRGSGLAGVQLSATSFVSRIRQL
                     VYPAGLTALPSNGLNQDHVPMALNGANAVSDAVEQAWLVVGSLAVAVTQYAALAGKSDD
                     APGVWAELARVSPALAADRPLAPEVRGARDVLARLATELIEREEESADAGYGA"
     gene            complement(19973..21133)
                     /locus_tag="EJ355_RS10070"
     CDS             complement(19973..21133)
                     /NRPS_PKS="Domain: AMP-binding (51-203). E-value: 5.6e-09.
                     Score: 27.0. Matches aSDomain:
                     nrpspksdomains_EJ355_RS10070_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EJ355_RS10070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_125262551.1"
                     /transl_table=11
                     /translation="MSHPELTPHALLTAGPAAPGVNERPWLVRWDLLGEDAGDLVRRTL
                     PPTLDFHTSGTTGPSECWRRTRDQLWEEAGMLAALLGPERPEAVLSFAPPRHVYGALAT
                     LLVPARLRLPVWYRPHFFGALPPSPVGRWAVVAVPWSFSALRRKRAWIEARERVAVLHS
                     TAMLPSAAQDFVQEAGPGRVSVREVFGSTETGGIAWREWGPDDPPWDLFDDVEFVPDPH
                     DPHAPDDGVGTPDADADVPLTVRSPRLAARPGLAPLPTWQTDDLVRPCGARRFRFSGRR
                     GGLVKINGRRVSLGAVERALRAVVDCADLACLPVADELSGEHLELYVVPPPGRRLDRAR
                     VRALIAGHDLTVQPRHVHVVDRIDRSPAGLPRRIHPTRPADAGAAT"
     CDS_motif       complement(20240..20305)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_EJ355_RS10070_0001"
                     /evalue="2.10E-05"
                     /label="NRPS-A_a8"
                     /locus_tag="EJ355_RS10070"
                     /protein_end="298"
                     /protein_start="276"
                     /score="17.2"
                     /tool="antismash"
                     /translation="FSGRRGGLVKINGRRVSLGAVE"
     aSDomain        complement(20525..20980)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS10070_AMP-binding.1"
                     /evalue="5.60E-09"
                     /label="EJ355_RS10070_AMP-binding.1"
                     /locus_tag="EJ355_RS10070"
                     /protein_end="203"
                     /protein_start="51"
                     /score="27.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HTSGTTGPSECWRRTRDQLWEEAGMLAALLGPERPEAVLSFAPPR
                     HVYGALATLLVPARLRLPVWYRPHFFGALPPSPVGRWAVVAVPWSFSALRRKRAWIEAR
                     ERVAVLHSTAMLPSAAQDFVQEAGPGRVSVREVFGSTETGGIAWREWG"
     gene            complement(21151..21414)
                     /locus_tag="EJ355_RS10075"
     CDS             complement(21151..21414)
                     /GO_function="GO:0000035 - acyl binding [Evidence IEA]"
                     /GO_function="GO:0000036 - acyl carrier activity [Evidence
                     IEA]"
                     /GO_process="GO:0009245 - lipid A biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PP-binding (12-79). E-value: 1.7e-16.
                     Score: 52.3. Matches aSDomain:
                     nrpspksdomains_EJ355_RS10075_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019819234.1"
                     /locus_tag="EJ355_RS10075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="acyl carrier protein"
                     /protein_id="WP_078618763.1"
                     /sec_met_domain="PP-binding (E-value: 1e-14, bitscore:
                     50.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDALMNQSAALRFVAEAVEEVAGIPAEEVEPGKSLVDDLGIDSLS
                     MVEIAFTLQRQAGDEIPDEELATITTVQDLVDLVRERVEHSQ"
     aSDomain        complement(21178..21378)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_EJ355_RS10075_PP-binding.1"
                     /evalue="1.70E-16"
                     /label="EJ355_RS10075_PP-binding.1"
                     /locus_tag="EJ355_RS10075"
                     /protein_end="79"
                     /protein_start="12"
                     /score="52.3"
                     /tool="antismash"
                     /translation="FVAEAVEEVAGIPAEEVEPGKSLVDDLGIDSLSMVEIAFTLQRQA
                     GDEIPDEELATITTVQDLVDLV"
ORIGIN
        1 tcgtccgcga agcgctcgta ctgcgcggcg aacgacgccc agtccatgcg ggtgcggccc
       61 gggtgggccg tgaacagctc gtggtagtac gcccaggaca gctcctggag cgccggtgcc
      121 cacaggtcgc ggtcgaagtc gaaccccggg cggcgcagcc gggcgcggca cgtctccggg
      181 gtgaggtgac gcggcggcgg acagggcgag ttcagggtgt acgcgggctt ggggtagggc
      241 gggacaccgc gacgggaacc cgcgtacagc acgggctcgc ggccggacgg gagatagcgg
      301 aggcggccgt cggggcgcga gcgcgtgaag cggccgccac ggccctcggt gagcagcagc
      361 aggcagtcga cgaagacgag cccgaggccg cgcacgacga ccggggcgcc ggtgggtatc
      421 cggtcgagcc cgtcctcgtc ggcgcgcccg gggccgatgc gggtgaggcc acggggggtg
      481 tcggtgacga cgtccgtgtg gccctgggcg aggacgagtt gggccgcggg caccgccccg
      541 cggccgctgt cgaggacgac gcactggcgg tccgtaccgg cgtggcggac gtcgacggcg
      601 gtcgcgcggt gcaggtgcag acgcaggttc ggggccatgt gggtgcgtac accatggaag
      661 aactcctgca aatagcgccc ttgcgcggga cgcgacgcgt aatggccgtc gtgcagcggg
      721 ccgccgccgg tctccgccag ccacctgccc gtcgtcggcc cggggtacgc gggtccggcg
      781 caccgcaccg agctgcccgg gaacatcgtc acctgctcgg cggccgagtt catccacagg
      841 agttcgctct gcgaggtccg ccaggtgcgt cctgaaccgg gcggaaaggg gtcgaccaga
      901 tggatcgcga attcccggtc gccaaggatt tccggagcgt tggccgcgat gcgttccagg
      961 atcgacgttc cgcgcgggcc cgcgccgatg acgcacacgg ccgctgaagg atcaccgtgg
     1021 tcctgcttca tggtcctctt tccggcaggg tgcacgagac gggtggggcg caacagaacg
     1081 ggcggggcga cggcacgggc ggccgcggag gtgttcaggg ccgcggccga gaacggcgca
     1141 ctccccttgt gcggggccgg accgctcatt actgtttctt tactgaccgc tcgaatcgct
     1201 tcatgatgag ccgtcaccgg gggagacagt gccatgccga atctacgaca tcccacaccg
     1261 aacatcagcg gcccgcagga gaagttaacc gtggacgacc gggcgcgcac gcgacggtca
     1321 tcgctctcgt tgcccgatta tctgccactg gaacactgga aaaccatcgg agagcagata
     1381 tttgccattg ttgattcatc cgcgtggtgg ttgggagact ggctggtatt cggccagcag
     1441 acgtatcccc gccgatatcg cgatgcgatc gagcaaacat cccttgacta ccagacgttg
     1501 cgcaactacg cctggatcgc ccgcaagttc ccgccgtccc gccggcggga cggactgagc
     1561 ctgcagcacc acgccgaggt cgcggcgctg ccggcaccgg cacaggacca ctggctgagc
     1621 ctggcggagg cgcacggctg gtcccgcaac gagctgcgcc gccatctgcg ggccgcgcgt
     1681 accgagtcgc aggatgcggg ggcgacggag gatgtgcagg tgaccgcgtc cgccgagcag
     1741 tgcgaccgct gggagaaagc cgcccagcac atggagagcg acctcaacga ctggatgatc
     1801 cgaaaggtcg acgaggccgc ggccaccgcg ctcggcccgg aaatcgcgga cgacgcggcc
     1861 cgttcccctc accccgactc gtccgtagcc tctgagtaat tccccgatcc ggtggccgcg
     1921 atatccgcgg tcgccgcatc gcggcgtcct gtcgcggccg gggagcaatc cgctcacgga
     1981 ggagaggcaa tatgccggag tctgccgcgt gccgcgtctg cggcggtgag gtcgtcgcct
     2041 tcatggactt cggggaacag ccgatatcgg actgcttcct gccgccggaa tcgacggatc
     2101 ccgaacactt ctaccggctg gtcgtcggag cctgtgaatc gtgcacgatg gtgcagcttc
     2161 tccacgaagt gccgcgcgag cgcatgttcc acgatcatta cccttaccat tcctccggat
     2221 ccgcccgaat gcgggaacac ttccggggcg tcgccgagcg tttcgtcggc accgaactga
     2281 ccggcgacga cgcgttcatc gtcgaactcg gctgcaacga cggggtcatg ctcgcgacgg
     2341 tcgccgaggc cggcatccgg catctgggcg tggagccctc cggctcggtc gccgacgtca
     2401 ccgccgcccg cggcatccgg gtgcgcaagg acttcttcga ggaggagacc gcccgcgcca
     2461 tccgcgccga cgacggccag gccgcggtca tctacgccgc caacaccctc tgccacatcc
     2521 cgtacatggg ctcggtgctg cgcggagtgc tggaactcct caccgccgac ggcgtgttcg
     2581 tcttcgagga cccctacttc gccgacatcg tgcggcagac gtccttcgac cagatgtacg
     2641 acgagcactt ctactacttc accgcccggt cggtggcgga gatggcgcgc cgccacggcc
     2701 tcgacctcgt cgacgtggag cgcctggccg tgcacggcgg ggaggtgcgc tacacgctgg
     2761 cccgcgcggg cgcgcgcgag cgcacggcgg ccgtcggcga gctgctcgcc gaggaggagg
     2821 cggcggagct gaccgcgcgc cacaccctgg agggcttccg cgaccgggtc ctgaaggcgc
     2881 gcgacgacct cgtctcgctc ctgcgcgagc tgcgctccga gggcaaggac gtcgtcggct
     2941 acggagccac cgccaagagc gccacggtgc tcaactactg cggcatcggc ccggagctga
     3001 tcgcgtacgt caccgacacc acgcccgcca aacagggcag gctgacgccc ggatcccaca
     3061 tcccggtggt gccccaccag cgcttcgccg acgaccgccc gccgtacgcg gtgctgttcg
     3121 cgtggaacca cgcggaggag atcatggcga aggagcagga gttccgggac gcgggcggac
     3181 ggtggatccg gtacgtgccc ggggtgcggg tggactgagg cctggtcgcg ggggcgggcc
     3241 cgcggggcgc cggtcagccc cgccagcgcc gaaggacgag cacggcgttg tggccgccga
     3301 agccgaagga gtggctgacg ccgaccgtca cgtcgtgctc ctgggcctgg tgcgcgacga
     3361 agttcatcgc cgggtcctcg ggggagtcgc agttgagggt gggcggcacg acgcccgtac
     3421 ggatggcctc cgtgacgacc gcggcctcca cggcgccgcc cgcagcgagc atgtggcccg
     3481 tcatgctctt ggtcgagctg acggggacgc ggtgcgcgtg gtcgccgtac acccggcgga
     3541 tcgcggtcag ctccgtggtg tcgttgagcc gggtgccggt gccgtgggcg ttgacgtagc
     3601 cgacgtcggc gggtgtggcg cgggcggcct ccagggcggt gcgcatcgcg cgttcggcct
     3661 gggcgccgtc gggggagggc gccgtcaggt ggtgggcgtc cgtggtggac gcgtagcccg
     3721 ccagctcggc gtggacctcg gcgccgcgac gccgggcgtg ggcggcgctc tccaggacca
     3781 ggacgccggc gcccgcgccc atcacgaagc cgtccctgtc cttgtcgaag gggcggctcg
     3841 cggtcgtcgg gtcgcccgtc ctgcgggaga gcacccgggc ccgcgccgcg gccgcgagct
     3901 cgagccggtc gaaggcgtcc atcccgccgg ccaccacgac gtcggcgcgg ccctcgcgga
     3961 tccagcgggc cgcctcgccg acgcacaccg tgccggtggc gcaggcggcg accatctcgg
     4021 cggacgggcc gcgggcaccg agctccaggc acacctcggc ggccgagctg atgcccatcg
     4081 tggggaacac ctgcgggctg accgcggcgt agccctcgtc gcgcatggcc atggcgttgc
     4141 gcgaggcgac acgcgtggag ccgatgatgg acccgacggc caccccgacc cgcggcgcga
     4201 gcacctcgtc gatctcgatc ccggcctcct ggagcgccat gcgggccgcc gcgacgacca
     4261 cctggatggt ccagtcggta cgccggacga cgtgccgcgg cagatggtgc tcgggctcga
     4321 agcccgggac ttcgccgccg atgcggaccg gcaggtcgcc cacctcgaac ccggtgatgt
     4381 cgcggatgcc gctcttcccg gcgacgagcg cggcccaggt gtcgggccag ttcggggcga
     4441 gcggggagac gacgccgcgg ccggtgacga cgacgcggtc gggcgcgggg tgcgtttcct
     4501 ggccggggcc ggggccgggg ccggagccgg agccggggat gcggtgctcg tgtcctgatg
     4561 cgctggtcat gccgtcgtct gccttcctgt gttcttcgcc tgggggtggg gtgcggctgc
     4621 caggggtggg cgtcggtgcc gttccgcgag gcggagcagt tcggggacgg cctcggcggg
     4681 gctcggcatg gcgtgcaggt cggcgcgcag ccgctgggcg ccttcggcga acgaggggtc
     4741 ggtgaggagc cgctggactt cgtgggcgac gcgttcgccg gtcgcctccg ccacctggag
     4801 gtcgattccg gcgccgtagg agctgacgcc gcgggcgagc cagatcgcgt cgagctgttc
     4861 ggcgagggag agttggggga cggcgtggag cgaggtcgtg ccgatcgtgc cgaacccgcc
     4921 gtgatgcacc atcaccgcac acgtaggagc aagcgctgcc aacggcacga actcctccac
     4981 ccgcacccgg tcccccacca ccgcacccaa ctgctcccgg atccccgccg cacccggcaa
     5041 cgccgccacc acctccacat ccagcgcggc gagcgccttg aggatctcca ccaccgacac
     5101 cgcgtacccg gcaagccgct ccaccgcact caaccccagc gtgaacccca cccgaggccg
     5161 caccggcacc tcccacaacc accgcggcac caccgacacc ccgttgtagg tcccgtagcg
     5221 gacggggacg tagtcggtgg ccgtgtcgaa ccggaagggg gccgggagca ggtcggcggt
     5281 gaactgaccc gtcgtcaact cctcgtcgaa ctccactccg taccgccccg cgagggtgcc
     5341 gagccactcg cccagcggat ccccgcccgt gcctccggcc gccgcctcct ccgccgcgag
     5401 acggacgaac tgctcccgca cccgcccgaa gaaatccacc ccccacgtca accgcccatg
     5461 cgccgcacca cacacccgcg ccgccacccc acccgcgaac gtccccggct cccacaccac
     5521 caactccggc tcccaccacc ggcacaaccc caccaactca tccaccaacg gctcattcac
     5581 caaccggaac caccacggca ccacatcccc ataacccgcc cgcaaatagt ccaacgacaa
     5641 caactcaccc ggcacatccg ccacatcgaa cggcggcagg tcgctgcccc cgaagcggct
     5701 tctgaactcc gggcgcagcg cgaggagtcg ccccatgccg tggtcgcggc cgacgggcac
     5761 ggccgtcaga ccggcccggg tgatctccgg caccagctcc ggctgactcg ccacccgcac
     5821 ctcatgaccg gccgccgcga aagcccgtgc cagcggcacc tggatgaaca ggtgggtctt
     5881 ttccgcgtag aggacgaaca ggacccgact cacgccgcat cgttctcctg gccggcggcc
     5941 gcgacgaaat cggcgaaggc gtcgaagtcg ccgccgctga atccgtgcag ttcctccagg
     6001 atgacgatgt tgaacttgtc ctccagatac agcacgagct gcaccatcgt gaaggagtcg
     6061 atgtcgtaca tctcggcgcc gtcccccgcg ccgtcctcgc gtgcgtagta ctgatccatg
     6121 aaggtctgga tctctttcct gacgcctgcc cggtccatct ccgtgagcct ttctgtgtcg
     6181 tggatcgcgt gctttttccg tcgctgtctc tttgtgccgc cgaggcggtc agtggggttc
     6241 cgccatggcg gccaggggga gctcaccggg tcgtttcagc ggctcccacc agttccggtt
     6301 gtccgcgtac cagcgcaccg tgtcgagaag tccctcgcgg aacgccacga gcgggcgatg
     6361 gccgagttct tcgcggatct tccggcagtc gatcgaatag cgccggtcgt gtcctttcct
     6421 gtcctcggtg aaacgcacct gggaccagtc ggcgtcgagg aactccagga gcagtttggt
     6481 cagttcggca ttggagatct ccgtgccgcc gccgatgttg tacgtctctc ccgggcgtcc
     6541 cgcaccggcg atgagggcga gaccccggca gtggtcgtcc acgtgaatcc actcgcgcac
     6601 ctgggagccg tcgccgtaca gcgggaccgt caggccgtcc aggaggcggg tgacgaacag
     6661 cgggatgagc ttttcgggga actggtaggg cccgtacgta ttggaggccc gggcggtgca
     6721 gacggggagc ccgtacgtcc ggtggaagga ccgggcgagc agctccgccg acgccttcga
     6781 cgccgaatag ggggagttgg ggcgcagcgg gaagtcctcg gtccaggagg ccgtctccgt
     6841 ctcgccgtac acctcgtcgg tggagaccag gacgaaccgg tcgacctccg tgcgcagcgc
     6901 ggcgcgaagc agttcgtagc tgccgacgat gttgctggcg acgaacgcgt cgccgtcgag
     6961 cagcgaccgg tcgacgtgtg actccgccgc gaagtgcacc accgtccgga cccccttgat
     7021 cgccctggcc acggcgtccc ggtcgcagat gtcggcctgg acgaaacgca gccgcgggtc
     7081 gtccagggcg cccgccagat tgctctgatt cccggcgtag gtcagcttgt cgaggaccac
     7141 gacctcggcg tcctcgaaac ccgcgtacgc ccccgcgagc atgcgccgca cgaagttcga
     7201 gccgatgaac ccggcacctc cggtcaccag gacacgcatg tccacctcct cctcacgccc
     7261 tgccccgcgc tcacgcgagg gcctccgcga cctcgcggac gtaccgtccg tagcccgaat
     7321 cgcccatggc caggcccagt tcgtggcact gcccggcgtc gatgaagccc atccgcagcg
     7381 cgatctcctc cagacacgcc acccgcacgc cctggcggtc catcaggacc tggacgtact
     7441 ggctggcgtc gagcagggaa cggaacgtgc ccgcgtcgag ccacgtgaag ccgcggccca
     7501 actgcacgag gcgggcggcg tgggcgtcga ggtagagctt gttgacatcc gtgatctcca
     7561 gttcgccgcg gtgcgaaggg cgcagtccgc gcgccatctc caccacgtcg ctgtcgtaga
     7621 agtagagccc cgtgatggcg ttcttggacg ccgggcaggc cggcttctcc tcgatgccga
     7681 tcaggtttcc gtgcgcgtcg gtctcggcca ccgcatagcg ctcggggtcc gccaccggat
     7741 agccgaagag cgtgcagccg tccgacttct cccgggcctc gcgcagcaag tcctggaatc
     7801 ctgccccatg gaacaggttg tcgccgagta taagcgcgga acggtcgttg ccgacatggt
     7861 cggcgccgat gatgtaggca tccgcgatac cgcgcggctc gggctgctgc gcgtacgtga
     7921 gattcattcc gagatgcgcg ccgtcaccga gcagaccacg catcgaaggc atggattccg
     7981 gtgccgcgat gatcaggacg tcccggattc cggccaacat caggaccgaa agcgggtaga
     8041 agatcattgg cttgtcgtag atcggcagga gttgcttcga cgtgcctgcc gtaatcggca
     8101 tgagacggct gcccgtgcct cccgcgagaa ctatcccttt cacctttcct cccgttgggt
     8161 catgctgtgc atcggttcct gtcggccgcc atgaagaccc gcggcgaaac tacgtgacat
     8221 tcgggggaca tgagcatgcg gattctcttc accgcctatg ccgtgcgcac gcatttcttc
     8281 agcatggtgt ccttggcgca cgccctggac acggccggtc atgaggtgcg ggtggcgagt
     8341 cagccggagc tggtgccgga gatcacccgg gccggtctca ccgccgtgcc cgtcggccgc
     8401 gaccaccagc tctggcgggt gctgaaggcc cggcacggcg acgaacgctg gtcggcactc
     8461 ccgccgttcg atgtggcgga tgtgccgggt gagttgttgt cgttggacta tttgcgggcg
     8521 ggttatgggg atgtggtgcc gtggtggttc cggttggtga atgagccgtt ggtggatgag
     8581 ttggtggggt tgtgccggtg gtgggagccg gagttggtgg tgtgggagcc ggggacgttc
     8641 gcgggtgggg tggcggcgcg ggtgtgtggt gcggcgcatg ggcggttgac gtggggggtg
     8701 gatttcttcg ggcgggtgcg ggagcagttc gtccgcctcg cgggcgaggc gggggagccg
     8761 gtgggtggcg cgggggatcc gctcggcgcc tggctgagcg atctcggcgg acgctacgga
     8821 gtcgcgtacg acgaggaatt gacgacaggt cagttcaccg tggaccagct gcccgaggcg
     8881 ttccgccttg agaccggcat cgaatatctg ccgatgcggt tcggcgtcta caacggggtg
     8941 tcggtggtgc cgcggtggtt gtgggaggtg ccggtgcggc ctcgggcggg gttcacgctg
     9001 gggttgagtg cggtggagcg gcttgccggg tacgcggtgt cggtggtgga gatcctcaag
     9061 gcgctcgccg ccctcgacgt ggaagtggtc gccgcgctgc cgggcgcggc ggagatccgc
     9121 gaggaactgg gcgcggtggg ggaccgggtg cgggtggagg agttcgtgcc gttggcagcg
     9181 cttgctccca cctgtgcggt gatggttcat cacggcgggt tcggcacgat cggtacgacc
     9241 tcgctgcacg ccgtccccca actcgccgtc gccgaggaga tcgacgcccc gatcctcgcc
     9301 aggggcctgg ccgcgtacgg cgccggagtc gacctcccgg tggcggaggc gaccggcgaa
     9361 cgcgtcgccc acgaagtgcg gcggctgctc acggaatcct ccttcaccga aggggcacgg
     9421 cggctgcgcg ccgacatgag ggccatgccg agcgccgccg acgtcgtccc cgaactggtc
     9481 cggatcgccg agcggcaccg gggccgctga gcgccggacg cgcgggacga cgccagggcc
     9541 acgcgtgcgg acggacagag acgtggcgaa gtgagtgaga agagagtgag tggggggtcc
     9601 ctgggctcag ggacccccca ccgccggctc agtcggcccg gctggcggcc gcggtggact
     9661 gccgctgcgg ccctctcgct ctcatcgcgt cgtcagcggg tcagcagttc acgctgcccg
     9721 tgctgccgag cagctcgtcg tcgagggtcg acgtctccag ctcctgaagc tccagaacgt
     9781 tcatgcggtg tcacctcctc cccagcgctc gctgcggtac cggcggcggt cggccgccga
     9841 agtcagtggt gcgacgcggt cggcggccgc cctggaccgc cgctgcggtt gttccgggtt
     9901 tgtcgtgccg tgacagcggg tcagcagccc acgctgccgg tgctgccgag cagctcgtcg
     9961 tcgagggtcg acgtctccag ctcctgaagc tccagaacgt tcatgcggtg tcacctccaa
    10021 ccggccgatc gcagggaatc cggcggcggt cgtccgccgg gagtccgtga tccgctccgg
    10081 ccgccgcccg cccggcgcgg cccaggaacg gcagcggggg aggcccgccg tccgtgacgt
    10141 acgacagggc cgcgaggacg cccgcgttgc ccgtcgccag gtccatggag agacgcaggc
    10201 cgctgtggcc ggggaacgcc acctcgccgc ggtgggcgag ggcgtgccag tggaggctgc
    10261 ccaggtgctc ggccaccggg tccgcgccgg cctcggcgcc ctcggaggcg gtggccggca
    10321 gatgccgccg cagcgcgtgc gccgccgcga ggagcccggc ccgcccgttg aacagctggc
    10381 tctcgaccgt gaggggcgag cgtgcggcga gcgcgagggc gggcagcgcc tcggcgatgc
    10441 gcgggtcgtc cgtgtggtcg gtgagcaggt cggcgacgag gccgatgccg accgacccgg
    10501 tctccaggta cggcagggag cggaagccgc cgtcgacgtg cagcacgcct tcctcgcgca
    10561 ggacacacag gtccagatcc cggtgcacgg cccgcaccgc gtgccgcagg tacgcgtcct
    10621 cgcccgtggc ctcgtacgtc cgcagcagga acaggccgac gccggaccag ccgcgcagca
    10681 gcccgccgtg ggtgccgggc tcgccccggg cgcggtcgat gccgtgcggg cggccgtcgt
    10741 ccagcgcgtc gacggcgcgc gcggccagct cccgggcctc cttgagccag gcgtgccccg
    10801 ggtcgtcgcc gacgaagtgc agcaggttga ggccgacgcc cgctaggccg ccgtacaggc
    10861 tgacgtcggt catctcttcg acaccggcgc gggcacggtc gatgagctcc cgggcggcgg
    10921 cgtggtggcc gagacggtcc aggacatggg cgacgccgtg cgcgccgtcg tggaagccgg
    10981 gccggacgtg gtcggcgcgt gccgcccgca gcagccagtc ctcgtacggg gttccgcgct
    11041 cgccgcccgc cacggacagg gcccacagga cgcccgcggc gccgtgcgcg aagccgccgg
    11101 gggcctcgtt gaactgccgg gggtcgccgg ggaagagccg gtcgtcgcgg tccggggtcg
    11161 cggacgcgtg cagggcgcgg gccagggagg cgcggacggc cgcccagtcg acgggcgagg
    11221 tgtcgaggcg tacgtcggct acggcaccga tcggtggcgg ggtgccgggg cgtgcggccc
    11281 gtccggcagt gtcccgggcg tgctcggcgg gctgcggggc ctgcgcgtcg ggtgcctcgg
    11341 ccaggcccgc cgcgatcgtc gcggcgaagt cgtccggcag gccgaagcgc tgtgccgccg
    11401 cggccgcgag gcgcgcgccc atgtccgggc agataccgag cgacgtcacg agcggcaggt
    11461 acagccacag ccgcagcacc gtcaaggcgt gttcgtcgac cgcggggccg gtcttgcggc
    11521 gggcggcgaa gccggggtag ccgagcgtcg ggcgggtgtt ctcggaggtg gggaaggcca
    11581 tctcgaagtc gacgaggcgg accttcgggg ccgtgtcggg cggtgtcgga cttccgccgg
    11641 atgccgctcg ctcgccgggc ccggcgtgct ccccgggctc ggcgtgcacc ccggggccga
    11701 acgcctcctc ggtggggccg aacgcgtctc cctcaggacc gaacgcgtcc tccgcgacca
    11761 gcacgttccc ggggtgcaga tccccgaaga cgatcccctc ggcgtgcacg cgccggacca
    11821 gcgcggccac ctcggcgtgc agggcctccg cgcgccgggc gtaggcgcgc aggccgtcgg
    11881 gcgtgcacgc gttccagttg atcagcgggt ggtggcgcac catccagcgc tgcagcggga
    11941 tgccgtccaa gtgctccatg gcgagcatgg agtggccgcc gaagtcgaac agctcgtacg
    12001 cacgcggcac gccggggacg tcggcgagcc ggtcgaggac gcgcttctcg tgcgccagcc
    12061 gtgccgtggc gtcgaggccc gcgccgtccc tgccggtgtg cggccgggcc tccttgagga
    12121 ccacggggct gccgtcgtcc cggcgcgtcg cggcgtacac gcccccggcg ttggagaagt
    12181 gcagcgcctc cttgacccgg tagccgaact cgccgctcgc cgccgtgcgt cgctcgatgt
    12241 gcgggcgcag ggcatccggg accggcacgc cctcgggcag cgcgaacgcg ggccgcctgc
    12301 ggtcgggcac gaggcggccg tcggagtcgg tgagggcgag cacgtgcgcg ccgtcgtccg
    12361 tccagcacca gcgttcgcgg aaggcgccgt agcggaagtg cacggggccc tcgccccagc
    12421 ggcagtcggt gaggatgtac ggcgcgtcgc tgcccgcgag gcgttcgtcc agctcgcgtg
    12481 cgcagtccgc gaactccgcc tcgtcgcgcg ggtagacggc gatgaacttg ccgccggccg
    12541 ggcggggcgc gtacttggag ttcatggcgt cgagcacggc cctgccgcgc aggtgcttga
    12601 agggcacgcg ggcccgcaga cagtggtcgg cgacgatctc gaggacctgc gcggcgttgt
    12661 cgtgggtcgc ggagacatgg atcttccagc cctggtccgg ggtgtgcggc tcgtcgggct
    12721 ggtacatgtc ccagacgcgg gcggcccggt gccgccagcc gtcgggcagc ggggcgaacc
    12781 gcgacggcac cagatgctcc tcggcggcgg cccgcgccgg ggtctcgaag aacaccgggt
    12841 ccaccagggt gtagatcgac cagtccacgg acacgaggca cctccagcgg aattcctgga
    12901 acggatcggc cgtgctgtcg acggccgtcg tggtgatcgc ctcgtggagg tttcgatcgg
    12961 tggtcagtga ccggtacttc cttcggtgag aagcatccgg tacgtggtga ggagccggta
    13021 caggagagtg tggggaatcg gatgcgaagg agaagtcggc gcgtgtgctg cgcgcctatc
    13081 gcgtgaaggg cgtcagcgcg gtggcggggc cccgtccgag atattccgcg agcgtccggc
    13141 gggcagccgc cttcggttcg ctcgccgtgt cgaaccaggc gtcctggccg ggcttctgct
    13201 cccattcccc tctgacgaac agcgcttcgt attcatggcg gagcatggac cacatggcca
    13261 cgtcgtgata ttcgcccttg aagaacttgc gttccctgag aactccctcg aggacgaaga
    13321 accgggtgcg catcaccatc tggagcatcg gttcgttgaa caggcccacc cagaactgga
    13381 gccggtgcgc gcccaagtcc tcgaagaggt gctccacgac gaggccgaag ccctcggcgc
    13441 catagccccg cgaccacagg tcgctgctgc cgatggcgcc gctgatctcg aaggtcgtgt
    13501 cccgctcgcc gccgacgcgg tggaacttca ccatgcccac gcgctccccg tccagggagc
    13561 gcatcgtgca gaagcgcgag cccgacgcgg cgtcggcgcg cagcgtgtcc accgtgaccc
    13621 gctccgacac gtcgccggtg agggcggcga catccccgtc ggggctgagc catttcgcga
    13681 attggccgta gtcgtcggcg gtcgcatatc cgagctcgac gcggcgtccg acgcgaatgg
    13741 cctcgctggt cttcggcgtc tcgatggtca tgaactcctg ctttcccggt gagtgcggcc
    13801 atcgttgccc ggggccggtc ccgcgtcaac cattcacgcg gattccgctt ccatcccccg
    13861 ccggtgcagg cgtagttcat gagtgattgc tctgtattcc gtctcgccgg cgggacacac
    13921 tggtgccaca cttctgtgga ttctcggccc gggagcgaca agccggaagc gaaacgttgg
    13981 aagcgacaag ggggaacgcc tgtgctcaca cattcccgcg acctgtatct ggatctgatg
    14041 aagaaggtcg tcaccaacac catctatcag gacaacgcgc acggctgggt gcggaacaag
    14101 gatttcgacg ccggccttcc gagcatcgaa tacgacgacg aactccgcgc gggcggccgg
    14161 gacatcccac gcgtcgcgca cacgatgatc ggcggcaaac gcctcgacaa cgtgcacgcg
    14221 tgcgtcgagc aggtcctctc cgacgacatc cccggcgacc tcatcgagac gggggtctgg
    14281 cggggcggcg ccacgatctt catgcgcgcg gtgctcaagg cgtacgacat caaggaccgc
    14341 acggtgtggg tcgccgactc cttcgagggc atcccgaagg gcgacccggt gcggtacccg
    14401 ggcgacgacc tggcgccgct gtatcgcttc aacgatgtct tcggtgtctc gcaggcgatc
    14461 gtggaggaga acttccgccg ctacggactc ctcgacgacc aagtgcgctt cctgcccggc
    14521 tacttccgcg acacgctgcc cgacgccccg gtggagagcc tggccgtgct ccgcatggac
    14581 ggcgacctgt tcgagtccac gatggacgcg ctggtgcacc tctaccccaa gctgtccgtc
    14641 ggcggctatg tgatcgtcga cgactaccgc gccctgcccc cgtgccgggt cgccgtctac
    14701 cagtaccgca gggagcacgg catcaccgac cccatcgagg agatcgacgg agtcggtgtg
    14761 ttctggcgac gtacacgctg acggggggag gggaccgccc gtcaggtcgg gcgcggcggg
    14821 ggcgcgtagg ctcccgccgc gtaccgctga cggcacaggc cccgctggat cttgccgctg
    14881 gtggtgcgcg gcagcgtccc cctgcggacc accaccgtgg cgtggaccgc gagcccgtgc
    14941 tggcggctca ctgtctgccg gatgcgttcc gtcagggcgt cgcggtcggg ctcgggcagg
    15001 gccgtcatcg ccgcgtcggc ctccatcagg acgatgagcc gctccgtcgg gtcgccctcg
    15061 acgccgatcg ccgtcgctgc caccggcgcc accgactcga cggtggcctc gatgtcctcc
    15121 gggtagtggt tgcggccccg cacgatgatg acgtcgtcca tgcggccgac cacatagagc
    15181 ccgccgtcgt gcacaaagcc ccagtcgccc gtccgcagcc acccgtcggc gtacacgcgc
    15241 gccgtccgct ccggcgcccg ccagtacccg tccgtgcgat tggggccgcc cacccagatc
    15301 tcgccgaccc ggcccgtggt ctcctggccg gtcgccgggt ccgcgatccg cacccgcacc
    15361 ccgggcaccg gcgtgccgtt gctcaccagg tgcaccgagt ccggcccgtc cggcaccggc
    15421 cgcacctcgc ccgccgtgag ggccgcgcgg tcgaagtggg cgccgaccgc tccggtcccg
    15481 ttgggcgtca tcgtcacgga cagcgtggcc tccgcgaggc cgtagcacgg caccggcgac
    15541 cgggggtcga ggcccgcgtc ggcgaacgcc gccacgaact ccgccaccga ccgtgcgtgc
    15601 accggctccc cgccgatggc gagcgcccgc agaccgctga ggtccagcga cgccacctcc
    15661 tcggcggtga cgcgccgcac gcagtgggtc aggccgaagt tgggcgtgac cgtccagtcg
    15721 gcgcggtagt ccgacagggc gcgcagccag cggtaggggc ggtgcaggaa gcccatcggg
    15781 ctgaggtgca ccatgtgcat cccggcgctc agcgggctcg cgatggcgca gacgagcccc
    15841 atgtcgtgga acagcggcac ccaggacacg gccgtcgtcg ccggcatgaa gcgcgaacgc
    15901 atctggtacg ccgccgccga caggttcgcg tgcgtgaccc gcacccccgc gggcgccccc
    15961 gtggagcccg acgtgtactg caggtacgcc acgtcgtcag gagccgcggg cgggcgccgc
    16021 cacttcgacg cccggtgcgc gggcacctcg tcgacgtgca gcacgggccc ctgctgccac
    16081 cccgtgccgc tgagcgcggt gcgcaccgcg ggccgcacct gcgacgtcgt caggacacag
    16141 cccggcgtac tgtcccgaag gaccgaacgc agccgcgtct ggctgcggaa cagctccggc
    16201 gcgtacaggg gcaccgcgat cacgcccgcg tacagacagc cgaggaaggc gaccacgtag
    16261 tgctcgtcgt gcgggcacag gaccgcgacc cgggcccggg tcggacacgc cgcctggagc
    16321 tcggccgcga cggcccgggc ccgctcgtcg agttcgcggt acgtcagcgt gacgacggtg
    16381 tccgtgcgcc gggccccgcc ccgcacccgg cggtcgccga gcacggtcac ggcgggcgcg
    16441 tcgccgcgct cggccgccag gcggcgcacc gtgtcggcca gatactccag gccgaccggc
    16501 tccggcccga gcgtcgacag ggtgaagccc gtgtccgtgg tcggcgtgtg cgcggtacgg
    16561 ggtgcctcgg tgctcatggg cgctctccca gggtgtcgcc gatacgggcg gcggacgctt
    16621 cgagctcgct gacgggcagc agcatctgcg tcgcggcgag ctcgcggtac agcgcgtcct
    16681 cgctcagcag ctcctcgtgg gtgccgacgg cccggatgcg gccgccgtcc atcacgacga
    16741 tccggtcggc catgctcacg gtggacaggc ggtgcgcgac caccacgacc gtggtctcgg
    16801 ccgtgatgcc ggtgatgacc tcccgcaggg cgttctcgtt gcgggcgtcg agctgcgagg
    16861 tgacctcgtc gagcagcagc agccgcggcc ggcgcagcag cgcgcgggcc acggcgaccc
    16921 gctggcgctc accgccggac agcttggtgc cgcggtggcc gacctcggtg tccaggccgt
    16981 gcggcagccg cgcgacgagc tcgccgaggc gggcctggtc gacgacgcgg cgcagctcgt
    17041 cctcctcgac gtacggcatc ccgatgcaca ggttgtcgcg gatcgtcccg gcgaggacgg
    17101 gcgcgtcctg ctcgacgtag ccgatggcgg cgcgcagctc gccgaggtcg agttcgtgga
    17161 cgtcacggcc gtccaggagc acggtgccgc tctgcggctc gtagaaccgc tcgatcagcg
    17221 agaacaccgt ggacttgccc gcgccggagg gacccacgaa cgcggtcatc ccggccgcgg
    17281 ggatctcgaa gctgatgccg tggtgcacca cgggcccgtc gccggggtag cggaagacga
    17341 cgtcgtggaa cgacagcgac gcgggcgcgg gcgcgcggtc cgagggggcc ggggccgggc
    17401 gcggcgcgct ttccggctcg gtgcgcagcc gcagcagctc gctgacgcgg gacatcgccg
    17461 cggccaccac gttgaaccgg atcatcgcgg tgaccagcgc accaaggggc ggcaccaggt
    17521 agaagagata gagcaggaac gcgatcaggc tgccgaggct catcgcgccg gacgccaccc
    17581 gggcaccgcc gacgcccagg acggcgagga acgccacctg gatcgtcacg gtgatgaacg
    17641 cgccgacgag cgagtcgagg cgggccacct tcaggctgtg ccgccaggcc cggcgcgcgc
    17701 cgcgctcggc gatctcggcc tcgctgttct ccgcgccgga ggccttgatg gtgcggaagg
    17761 tgccgagcgc ccgctccagg gcggtgctca gctcggccac gccctcctgg gcccggcgcg
    17821 cggcgctctc cagctgcggc aggccggtgg cgacgaggat cccgccgagc agcaccacgg
    17881 cgagcgtggt gagcagcagc acccagtcca tgacgcccat caggacgagg atcgcgacga
    17941 gcatcaccga gccgttgacg gtctccacga tcgcggtcgt gacggcgctg cgcatcagcg
    18001 tggtgtcggc cgtggcccgc gacatcaggt cgcccggagg gatcttgtcc gtctcggcga
    18061 cccgcagcca cagcacccgc cggatcacct cgcggcgggt gctgagaacg acggattcgg
    18121 agacccgcat caggatgaac gtgccgatcg cgccgaccac cgccgacacc agcacgagag
    18181 ccgtcagcgc gatcagcgcg gccatgacgg gggagcgcga ctccaggttc tccaccacgg
    18241 acttggcgat cacgggctgg atcaggccgg agaagccgcc gagcagcgaa aggccgccgc
    18301 cgagcaggat gagcctgcgc tggggccgca gatagcggag catgtcccgc cacgcgtcgg
    18361 ggcgcagaat ggccggacgg ccggactccg cgcgctcctc gggctcccgc tcgtccggcg
    18421 ggtcggtctc acgtgcggtg tcaggcgccg tacccagcat ctgcgctctc ctcctcgcgt
    18481 tcgatgagct ccgtcgcgag gcgcgcgagg acgtcgcggg cgccgcgcac ctcgggcgcg
    18541 agcggccggt cggccgccaa cgcgggcgag acgcgggcca gttcggccca tacgcccggg
    18601 gcgtcgtcgc tcttcccggc caacgccgcg tactgcgtca ccgcgacggc gagcgagccc
    18661 acgaccagcc acgcctgctc gacggcgtcg ctcacggcgt tcgcgccgtt gagggccatc
    18721 ggcacatggt cctggttgag gccgttgctg ggcagcgccg tcaggcccgc ggggtagacg
    18781 agctgacgga tacgggagac gaacgaggtg gcgctgagct gcaccccggc gagaccgctg
    18841 ccgcgcccgg gcacgggggt gagcatgggc ggcttgccgc cgttggtctc cggcaggcac
    18901 agcagggcga gttggcgctc ggcgaggaac gcgatctgct ggaggcacag gccgatctgg
    18961 tcggacgcga ggcccaccgg catggcgtgg aagttgcccg cgtgcaggaa ctcgccctcg
    19021 tagtagaccg ggttgtccgt acagcccacc gcctcgcgga ccaggatgtc ctcgaggacg
    19081 gacagctggt cgacgaccgc gccgatcacc tgcggcgcgc agcgcaggct gtacggctcc
    19141 tgcagcgggc gcgccggatc gcggcggtgg tccggcggca ggtcctccct gatccaccgg
    19201 gcggcgacca actgccccgc ctggccccgc gcgtgaccga ccccggggtg gtacgcctgc
    19261 gggctcgcgc cgagcagcgt caccgcgcgc gcggtgagcg ccgcgaccgc gcgggacagg
    19321 cgcagcacct cccggtggtt gagcagggtg acggcgaggc tcacgctggt gccgttgacg
    19381 aacgaaaggg cctgccgggc ccgccaggtc accgggcgcg cgccgagcgc ggccagggcc
    19441 tcggccgacg gccgcacccg ccattgcccc gagccgtcgc gcagccatgc ctcgccctcc
    19501 cccgcaaggg cgagcgccgc gtgcgcgagg ggctgcaggt cgccgctcgc gctgaccgtg
    19561 ccgtcgcgcg ggatcaccgg agtgaagccc tggttccaca actcggcgac ccggtcccag
    19621 aattcgggcg acaccgctga gtggccgagc cgcatgctgt tgagccggat ccacagcacc
    19681 aggcgacaga cctccgggga cagcggctgc ccctgcccgc tgccgaggtg cgcgatgagc
    19741 ccgctgccct ggtcggtgtc ggacgcggcg gccgcgtatt cgaccagcgg gccgaagccc
    19801 cgcgtgaccc cgtacacctg ctcccggtcg gcgagggccc gggcgagccg gtcgactccg
    19861 gcccgcatcc gctcggcctc cagcgcgctg cacgggcgca cccgggcgtc ggggcgggcc
    19921 tggcgcacga tgtccgccag gcgttccttg ggcgactcgg ctacgtctgt gatcatgtcg
    19981 cggctcctgc gtcagcgggg cgggtggggt ggatccggcg cggcaggccg gccggggagc
    20041 ggtcgatgcg gtcgacgacg tgcacgtggc ggggctggac ggtgaggtcg tggcccgcga
    20101 tgagcgcgcg cacccgggcc cggtcgagac gacggccggg aggcggtacg acgtacagct
    20161 ccaggtgctc gccgctgagt tcgtcggcga cgggcaggca ggccaggtcc gcgcagtcga
    20221 cgaccgcgcg cagcgcacgc tcgacggcgc cgaggctcac ccgacgcccg ttgatcttca
    20281 cgaggccgcc gcgccggcca ctgaagcgga accggcgtgc cccacagggc cgtacgaggt
    20341 cgtcggtctg ccaggtgggg agcggggcga ggccggggcg ggcggcgaga cgggggctgc
    20401 ggaccgtcag ggggacgtcc gcgtcggcgt ccggggtgcc gacgccgtcg tcgggggcgt
    20461 gggggtcgtg ggggtcgggg acgaactcca cgtcgtcgaa caggtcccag ggcgggtcgt
    20521 cgggacccca ctcccgccag gcgatgccgc ccgtctccgt ggacccgaac acctcccgca
    20581 ccgacacccg cccggggccc gcctcctgga cgaagtcctg cgcggccgac ggcagcatcg
    20641 cggtgctgtg gagcacggcg acgcgctcgc gggcctcgat ccacgcgcgc ttgcggcgca
    20701 gcgccgagaa cgaccagggc accgcgacga ccgcccaccg gcccacgggg gacgggggca
    20761 gcgcgccgaa gaagtgcggg cggtaccaga cggggaggcg gagtctggcc gggacgagca
    20821 gggtcgcgag cgccccgtac acatgccggg gcggcgcgaa cgacaggacg gcttccgggc
    20881 gttcgggccc aaggagcgcg gccagcatgc ccgcctcctc ccacagctgg tcgcgggtgc
    20941 gccgccagca ctcgctgggg ccggtcgtgc cggacgtgtg gaagtccagg gtcgggggca
    21001 gtgtccggcg caccagatcc ccggcgtcct cgccgagcag gtcccaacgg accagccagg
    21061 ggcgctcgtt gacgccggga gcggcggggc ccgcggtcag gagtgcgtgc ggggtcagct
    21121 cgggatggct caccaggtca cctcgtgtcg tcactgactg tgttcaaccc gttcccgcac
    21181 caggtcgacg agatcctgca ccgtggtgat cgtggccagc tcctcgtcgg gtatctcatc
    21241 acccgcctgc cgctggagcg tgaaagcgat ctccaccatg gagagggaat cgatcccgag
    21301 atcgtccacc aaggacttac cgggctccac ctcttcggcc ggaattccgg ctacttcttc
    21361 caccgcttcg gcgacgaatc gaagtgcggc gctctggttc atgagtgcgt ccatggctat
    21421 ctcctatttc atcgatgcgg gaacggtcaa tccactcctg tcccgatccc attggaaaat
    21481 gtcgggaaac ggctcgtcgt gcccggtcag aagtgtcgtg gcagaaatag cggcgggttg
    21541 ttgtccactt gtggtccagg ggcgtgcgcc ggtaagaaca cgggacttgt ggggtcatga
    21601 cggcggcatc accacgcgtc cgcgccgtgc ctcccgccga ccgtcccgcc ggcgggacgc
    21661 cgtgccgcgt cccggaccga cccctgccca ccgtcgtcgg gaaccggccc ccgacgcccg
    21721 gtcccgcgca tccggaacgg cctgcccgcg cggttctgcc gcctccgggc cgaccacccg
    21781 cgttgcgaaa agcgcaggcg cgcccggacc cgccgcatga cacggcgacg cgcacaaacc
    21841 gcgggaatca gaccgcgccg gaaggcgatc aaccgcatgc tccggtccgg gatcaccatc
    21901 ggcccatccg gaacaaccgg ccattcattc ccctggacac cgcgccgtga cctgccgcag
    21961 actgccggag tctcgggacg actcgaggca ggtgagagta cagcacgctc acacggagga
    22021 tgtcttgcca agcaagaggc acgggggaat acctcccggc gtgaggccgc taccgcactc
    22081 gattcctacg gcgattccca accagatttc tcatcagatt cccagaacca ttgcgggagg
    22141 gctgcccaga gaccacaatc catcgaacgt gcaggaccgt aaattcggat cgcagttgca
    22201 tgtgaacgcg tccgtggtgg cccggcgcac ctcgctcgac ctgccggtcg acctcccgct
    22261 ggaccgctgg cgcagtctcg gcacgcacat cgccgtcatc gcggaatcgt ccagctggtg
    22321 gctcggggac tggctcatct acggccaggc ccactacccg gaccgctaca agatcgccct
    22381 cgccgacacg tccctgagct accagacgct gcgcaactac gcctgggtcg cgggccggtt
    22441 cggagtggca cgacggcgcg gccggctcag cttccagcac catgccgagg tggcgggtct
    22501 ggaggagcgg gcccaggacc actggctgga acaggccgaa cggcacggct ggtcccgcaa
    22561 cgaactgcgc cgccacatca gggagagcct gcgcgcaccc gagagcagac cgccggtgga
    22621 ggcggcgacg cggccggggc agagcgagaa gcaggcagcc atccgcttca agatcacgac
    22681 agagcggcgc atccgctggc agaaggccgc ggccaaccag ggccaggcgc tcgccgagtg
    22741 gatcgtcgcc gtactcgacc gctgcgcgcc cgcgacggtg cgccccgccg acggcgccac
    22801 cgtcgacctc ccgcaccacc cggtcctcgc cgggcgtgcg ctggaggagt gcggcgccgc
    22861 ccacgcgc
//
