GCF_003856495.1 - 9 region(s) - antiSMASH results

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Location: 422,369 - 463,526 nt. (total: 41,158 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

EG886_RS02390: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acetyltransferase aminotransferase methyltransferase

EG886_RS02315: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

EG886_RS02325: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

EG886_RS02395: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase

EG886_RS02385: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

EG886_RS02400: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

EG886_RS02320: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.69	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001817.5	0.49	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0002403.2	0.48	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000898.5	0.46	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001747.3	0.45	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000783.3	0.44	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0002567.2	0.44	other (other)	EDHA	Streptomyces sp. MA5143a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.69	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001962.3	0.50	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001817.5	0.49	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0002403.2	0.48	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0000898.5	0.46	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001747.3	0.45	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000783.3	0.44	saccharide	O-antigen	Xanthomonas oryzae pv. oryzae
BGC0002567.2	0.44	other (other)	EDHA	Streptomyces sp. MA5143a

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.18 out of 27.78

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.50 out of 26.85

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.40 out of 27.78

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.28 out of 19.52

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.13 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.79 out of 20.97

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

Additional weak hits (26):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.55 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.03 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.45 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.56 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.17 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.03 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.74 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.05 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.78 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.94 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.39 out of 28.14

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.09 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.90 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.10 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.92 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.51 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.53 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.62 out of 27.78

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.11 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.32 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.93 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.77 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.40 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.75 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis

NZ_CP034118.1 - Region 2 - terpene

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Location: 694,570 - 716,474 nt. (total: 21,905 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.41	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000670.4	0.27	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0000663.5	0.23	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001052.5	0.20	NRPS, PKS	tirandamycin	Streptomyces sp. 307-9
BGC0001298.4	0.19	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0001702.3	0.18	NRPS, PKS	nocamycin	Saccharothrix syringae
BGC0002649.2	0.18	NRPS, PKS	nocamycin V	Amycolatopsis sp. EV170708-02-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.41	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000670.4	0.27	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0000663.5	0.23	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0001052.5	0.20	NRPS, PKS	tirandamycin	Streptomyces sp. 307-9
BGC0001298.4	0.19	PKS	4-Z-annimycin, 4-E-annimycin	Streptomyces calvus
BGC0001702.3	0.18	NRPS, PKS	nocamycin	Saccharothrix syringae
BGC0002649.2	0.18	NRPS, PKS	nocamycin V	Amycolatopsis sp. EV170708-02-1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

EG886_RS03640: T2TS

Domain 1 (5 - 624): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.06 out of 23.79

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.45 out of 25.88

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.74 out of 28.14

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.88 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.15 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.93 out of 28.19

Confidence: medium

Additional weak hits (7):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.60 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.97 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.65 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.38 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
PerR	Peroxide regulator
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP034118.1 - Region 3 - NI-siderophore

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Location: 885,795 - 920,470 nt. (total: 34,676 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EG886_RS04595: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: deaminase peptidase

EG886_RS04505: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

EG886_RS04550: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Lyases: decarboxylase

EG886_RS04580: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase

EG886_RS04545: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.5	0.68	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5	0.59	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.57	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000942.4	0.56	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001478.5	0.51	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002471.3	0.50	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0002527.2	0.50	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000947.5	0.50	other (other)	vibrioferrin	Vibrio alginolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000943.5	0.68	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0000946.5	0.59	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.57	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000942.4	0.56	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001478.5	0.51	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0001572.3	0.51	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002471.3	0.50	other (other)	baumannoferrin A, baumannoferrin B	Acinetobacter baumannii AYE
BGC0002527.2	0.50	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000947.5	0.50	other (other)	vibrioferrin	Vibrio alginolyticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.81 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.84 out of 29.38

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.44 out of 28.19

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.23 out of 19.52

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.91 out of 19.26

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.13 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.38 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (24):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.72 out of 32.93

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.26 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.65 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.30 out of 36.54

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.44 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.00 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.50 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.27 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.51 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.18 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.95 out of 29.38

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.25 out of 30.97

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.61 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.36 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.90 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.55 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.13 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.99 out of 29.25

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CRP	Cyclic AMP receptor protein
FuR variant 1	Ferric Uptake Regulator
MexT	Global virulence regulator
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_CP034118.1 - Region 4 - terpene-precursor

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Location: 1,106,746 - 1,127,645 nt. (total: 20,900 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

EG886_RS05565: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

EG886_RS05595: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

EG886_RS05605: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001594.3	0.37	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000642.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001594.3	0.37	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

EG886_RS05595: PT_FPPS_like

Domain 1 (33 - 298): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.21 out of 20.97

Confidence: medium

Additional weak hits (3):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.53 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.49 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.37 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
MexT	Global virulence regulator
ToxT	Regulator of MSHA biosynthesis

NZ_CP034118.1 - Region 5 - RRE-containing

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Location: 1,160,594 - 1,181,508 nt. (total: 20,915 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: glucosidase

EG886_RS05860: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000616.4	0.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000600.3	0.39	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001779.5	0.39	ribosomal	siamycin	Streptomyces nodosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000616.4	0.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000600.3	0.39	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001779.5	0.39	ribosomal	siamycin	Streptomyces nodosus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 28.19

Confidence: medium

Additional weak hits (10):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.21 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.53 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.78 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.28 out of 28.14

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.29 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.83 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.32 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.76 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.44 out of 28.19

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 30 - 85; Score: 30.6

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP034118.1 - Region 6 - lanthipeptide-class-ii

BGC0001229.4 (SBI_06989):

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Location: 1,250,699 - 1,278,079 nt. (total: 27,381 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

EG886_RS06295: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

EG886_RS06315: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Isomerases: isomerase

EG886_RS06340: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase synthetase

EG886_RS06245: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

EG886_RS06335: 3-dehydroquinate synthase

smcogs: SMCOG1183: 3-dehydroquinate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.64	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000520.5	0.57	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.55	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.55	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000552.3	0.54	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000497.3	0.53	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.64	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000520.5	0.57	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.55	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000554.4	0.55	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000525.5	0.55	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000552.3	0.54	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000497.3	0.53	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EG886_RS06295

EG886_RS06300

Leader:

MSMQERALRDPKLRFEGFEHPAGMVNEDELMNIVGA

Core:

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDCR

Core with dehydrations:

GEVRPQDhaGPVCysAVDhbLAVCysVPVDhaLAFCysPDhbDhbACysDhbDhaDCysR

antiSMASH-DB 4.0 matches for EG886_RS06300

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDCR

50.0%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

GEVRPQSGPVCAV-TLAVCVPVSLAFCPTTACTSDC

GEV P + CA+ T+A S A CPTTAC+S C

GEVTPYTTWGCAIFTIA-----SAAQCPTTACSSKC

47.2%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V PQ+ P ++A + VS FCPTT CTS C

GDVDPQTTPS---SVACGIAVSALFCPTTKCTSQC

with 125 more sequence matches

Only the first 10 are displayed here.

44.4%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P +AV SL CPTT CTS C

GDVNPETTPATPTIVAV----SLGICPTTKCTSKC

41.7%

NC_009328.1and 1 other:

NZ_PIJH01000018.1 Lanthipeptides: CV632_RS18055_lanthipeptide

Lanthipeptides: GTNG_RS18990_lanthipeptide

EVRPQSGPVCAVTLAVCVPVSLAFCPT

EV PQS VC V+L +C SL FCP+

EVSPQSTIVC-VSLRIC-NWSLRFCPS

41.7%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27830_lanthipeptide

Lanthipeptides: BCK_RS27830_lanthipeptide

GEVRPQ--SGPVCAVTLAVCVPV-SLAFCPTTACT

G+V P+ S PV TL + VP+ + CPT CT

GDVNPEIMSDPV---TLTIVVPIFTNKLCPTVPCT

41.7%

NZ_CP006058.1and 25 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS19790_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03330_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12920_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18410_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14705_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03575_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03180_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP063276.1 Lanthipeptides: IM743_RS02810_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03410_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03215_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03235_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10980_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15460_lanthipeptide

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

+V P + P +L V V+ AFCP+T CTS C

ADVTPHTTPS---SLPCGVFVTAAFCPSTKCTSSC

41.7%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P T + V +S+ CPTT CTS C

GDVSPETTPA---TPTIVVAISVGLCPTTKCTSKC

41.7%

NZ_CP085411.1and 1 other:

NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide

Lanthipeptides: LIT28_RS29915_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P A V V +++ CPTT CTS C

GDVNPETTPTTATVTTVLVGATISVCPTTKCTSRC

41.7%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

CAVTLAVCVPVSLAFCPTTACTSDC

CAV AV VS + CPTT CTS C

CAVVTAVATLVSASACPTTKCTSQC

41.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

EVRPQSGPVCAVTLAVCVPVSLAFCPTTACTS

E++P+ P L V +P+SLA CPTT C S

EIQPKWTP-----LTVTIPISLAGCPTTKCAS

41.7%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P T + V +S+ CPTT CTS C

GDVSPETTPA---TPTIVVGISVGLCPTTKCTSKC

41.7%

NZ_QNUC01000031.1and 1 other:

NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide

Lanthipeptides: DN396_RS23045_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P A V V +++ CPTT CTS C

GDVNPETTPTTATVTTVLVGATISICPTTKCTSRC

MIBiG 4.0 matches for EG886_RS06300

40.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

VCAVTLAVCVPVSLAFCPTTACTSDC

+ A+ V V VS AFCPTT CTS C

IVAIQAGVAVGVSAAFCPTTKCTSRC

38.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

SGPVCAVTLAVCVPVSLAFCPTTACTSDC

+GP+C S AFCPTT CTS C

TGPLCVAASVA---ASAAFCPTTKCTSKC

EG886_RS06305

Leader:

MSREIRMWKDPVFRLQSEGSMMEHPSGNVMEELREQDLLSVAGG

Core:

CDWWNISCHLGNTGRFCTLTKECQPNCNY

Core with dehydrations:

CysDWWNIDhaCysHLGNDhbGRFCysDhbLDhbKECysQPNCysNY

antiSMASH-DB 4.0 matches for EG886_RS06305

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCNY

89.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

CDWWNISCHLGNTG+FCTLTKECQP+CN

CDWWNISCHLGNTGQFCTLTKECQPSCN

69.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNC

C++WNISCHLGN G CTLTKEC+P C

CNFWNISCHLGNDGSVCTLTKECRPAC

with 102 more sequence matches

Only the first 10 are displayed here.

65.5%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C+W+NISC LGN G++CTLTKECQ +C

CEWYNISCQLGNKGQWCTLTKECQRSCK

65.5%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

WWNISCHLGNTGRFCTLTKECQPNCN

WWN+S +LGN GR CTLTKECQ CN

WWNVSKNLGNKGRICTLTKECQSMCN

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C WWN+SCHLGN G++CT +KEC P CN

CSWWNVSCHLGNDGKYCTASKECMPTCN

62.1%

NZ_CP006058.1and 23 others:

NZ_CP006058.1 Lanthipeptides: BAMY6639_RS13800_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP021892.1 Lanthipeptides: S100333_RS03315_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP026533.1 Lanthipeptides: C3438_RS12905_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP028961.1 Lanthipeptides: DBK22_RS18395_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS14690_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP044132.1 Lanthipeptides: F5K02_RS03560_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP061087.1 Lanthipeptides: IAR44_RS03165_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP065791.1 Lanthipeptides: I8N73_RS03395_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP074348.1 Lanthipeptides: KHA74_RS03200_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_CP083943.1 Lanthipeptides: LCH16_RS03220_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAAHBR010000013.1 Lanthipeptides: G3T15_RS10965_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptideNZ_JAQEMJ010000013.1 Lanthipeptides: PGW53_RS15475_lanthipeptide

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W++ISC LGN G +CTLT ECQ +CN

CAWYDISCKLGNKGAWCTLTVECQSSCN

62.1%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+++SC LGN G +CTLT ECQ NCN

CAWYDVSCRLGNKGAWCTLTVECQNNCN

59.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+NISC LGN G +CTLT EC P+CN

CAWYNISCRLGNKGAYCTLTVECMPSCN

58.6%

Lanthipeptides: allorf_075467_075682_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNC

C WW++SCHLGN G CTL+ EC+P C

CTWWDLSCHLGNDGSTCTLSVECRPAC

56.7%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN G +CTLTKECQPNCN

FSLSDFLGNQGGWCTLTKECQPNCN

56.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGNTG +CTLT ECQPNCN

FSLSDVLGNTGGWCTLTVECQPNCN

56.7%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN+G +CTLTKECQPNCN

FSLSDALGNSGGWCTLTKECQPNCN

MIBiG 4.0 matches for EG886_RS06305

65.5%

Lanthipeptide: haloduracin β or haloduracin α

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+NISC LGN G +CTLT EC P+CN

CAWYNISCRLGNKGAYCTLTVECMPSCN

56.7%

Lanthipeptide: birimositide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN G +CTLTKECQPNCN

FSLSNALGNNGGWCTLTKECQPNCN

28.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTKECQPNCN

CTL+KECQPNCN

CTLSKECQPNCN

EG886_RS06310

Leader:

MNQLVRSWKDPLFRVQTEQNRMEHPSGNVLEELREQDLLSVAGG

Core:

CDWWNISCHLGNTGQFCTLTKECQPSCNR

Core with dehydrations:

CysDWWNIDhaCysHLGNDhbGQFCysDhbLDhbKECysQPDhaCysNR

antiSMASH-DB 4.0 matches for EG886_RS06310

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCNR

89.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

CDWWNISCHLGNTG+FCTLTKECQP+CN

CDWWNISCHLGNTGRFCTLTKECQPNCN

72.4%

NC_021362.1and 29 others:

Lanthipeptides: BALI_RS00925_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C+W+NISC LGN GQ+CTLTKECQ SC

CEWYNISCQLGNKGQWCTLTKECQRSCK

with 101 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSC

C++WNISCHLGN G CTLTKEC+P+C

CNFWNISCHLGNDGSVCTLTKECRPAC

65.5%

NZ_CP006058.1and 23 others:

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W++ISC LGN G +CTLT ECQ SCN

CAWYDISCKLGNKGAWCTLTVECQSSCN

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C WWN+SCHLGN G++CT +KEC P+CN

CSWWNVSCHLGNDGKYCTASKECMPTCN

62.5%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+NISC LGN G +CTLT EC PSCN

CAWYNISCRLGNKGAYCTLTVECMPSCN

62.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

WWNISCHLGNTGQFCTLTKECQPSCN

WWN+S +LGN G+ CTLTKECQ CN

WWNVSKNLGNKGRICTLTKECQSMCN

58.6%

Lanthipeptides: allorf_075467_075682_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSC

C WW++SCHLGN G CTL+ EC+P+C

CTWWDLSCHLGNDGSTCTLSVECRPAC

58.6%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+++SC LGN G +CTLT ECQ +CN

CAWYDVSCRLGNKGAWCTLTVECQNNCN

55.2%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

ISCHLGNTGQFCTLTKECQPSCN

+S LGNTG CTLTKECQ CN

LSRKLGNTGYVCTLTKECQRMCN

55.2%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS17475_lanthipeptide

ISCHLGNTGQFCTLTKECQPSCN

+S LGN G+FCTLT EC PSCN

LSSLLGNDGKFCTLTVECMPSCN

54.8%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C WWN+SCHLGN G+ CT++ EC CN

CSWWNLSCHLGNNGKLCTVSHECAAGCN

MIBiG 4.0 matches for EG886_RS06310

69.0%

Lanthipeptide: haloduracin β or haloduracin α

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+NISC LGN G +CTLT EC PSCN

CAWYNISCRLGNKGAYCTLTVECMPSCN

53.3%

Lanthipeptide: birimositide

WNISCHLGNTGQFCTLTKECQPSCN

+++S LGN G +CTLTKECQP+CN

FSLSNALGNNGGWCTLTKECQPNCN

25.6%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTKECQPSCN

CTL+KECQP+CN

CTLSKECQPNCN

EG886_RS06325

Leader:

MKLTAREREVALLVACGYTDTEIAEELGV

Core:

SRRRICEIVSSIKFKWKTRSRVEIGIIVYYLGWIKEELSGKDLLSALR

Core with dehydrations:

DhaRRRICysEIVDhaDhaIKFKWKDhbRDhaRVEIGIIVYYLGWIKEELDhaGKDLLDhaALR

antiSMASH-DB 4.0 matches for EG886_RS06325

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06325_lanthipeptide

Lanthipeptides: EG886_RS06325_lanthipeptide

SRRRICEIVSSIKFKWKTRSRVEIGIIVYYLGWIKEELSGKDLLSALR

31.2%

NZ_CP012102.1:

Lanthipeptides: AC241_RS31270_lanthipeptide

IKFKWKTRSRVEIGIIVYYLGWIKEE

IK K K SRV+IGI+ Y+LGW+ E

IKSKCKISSRVKIGILAYHLGWLHFE

14.6%

NZ_CP101655.1and 1 other:

NZ_JAHHZH010000008.1 Lanthipeptides: allorf_106741_106917_lanthipeptide

Lanthipeptides: allorf_2707176_2707352_lanthipeptide

SSIKFKWKTRSRVEIGI

S++ F W TR + +IG+

STLGFFWNTRGKHKIGM

allorf_1264292_1264399

Leader:

MTNTPLLQDCFGA

Core:

NKDYYISKNYFKEFRVYLHFCV

Core with dehydrations:

NKDYYIDhaKNYFKEFRVYLHFCysV

antiSMASH-DB 4.0 matches for allorf_1264292_1264399

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1264292_1264399_lanthipeptide

Lanthipeptides: allorf_1264292_1264399_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

30.4%

NZ_CP024848.1:

Lanthipeptides: allorf_0212665_0212793_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

N D + KN++ F Y C

NMDTHQEKNFWTIFLSYTRICA

30.4%

NZ_PIOD01000016.1:

Lanthipeptides: allorf_242568_242714_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

N D + KN + F Y C

NMDTHQEKNLWTIFLSYTRICA

with 1 more sequence matches

27.3%

NZ_AP018254.1:

Lanthipeptides: allorf_3293275_3293364_lanthipeptide

FKEFRVYLHFCV

FK F ++LH C+

FKSFTIHLHVCL

MIBiG 4.0 matches for allorf_1264292_1264399

10.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

FRVYLH

FRV H

FRVSSH

allorf_1271752_1271961

Leader:

MPAPADVVHAS

Core:

RLFSARLRVPFSAPLISAQHSVGRKKDLSLTLIAHETSCTLRSLRRQARASRRLTPLG

Core with dehydrations:

RLFDhaARLRVPFDhaAPLIDhaAQHDhaVGRKKDLDhaLDhbLIAHEDhbDhaCysDhbLRDhaLRRQARADhaRRLDhbPLG

antiSMASH-DB 4.0 matches for allorf_1271752_1271961

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271752_1271961_lanthipeptide

Lanthipeptides: allorf_1271752_1271961_lanthipeptide

RLFSARLRVPFSAPLISAQHSVGRKKDLSLTLIAHETSCTLRSLRRQARASRRLTPLG

8.6%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_250966_251172_lanthipeptide

RLFSARLRVPFSAP

+++++ R P+SAP

KVWNSTFRFPWSAP

allorf_1271778_1271840

Leader:

MHGLAGG

Core:

VSGVCTKFRARSE

Core with dehydrations:

VDhaGVCysDhbKFRARDhaE

antiSMASH-DB 4.0 matches for allorf_1271778_1271840

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271778_1271840_lanthipeptide

Lanthipeptides: allorf_1271778_1271840_lanthipeptide

VSGVCTKFRARSE

Lanthipeptide(s) for EG886_RS06315

EG886_RS06300

Leader:

MSMQERALRDPKLRFEGFEHPAGMVNEDELMNIVGA

Core:

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDCR

Core with dehydrations:

GEVRPQDhaGPVCysAVDhbLAVCysVPVDhaLAFCysPDhbDhbACysDhbDhaDCysR

antiSMASH-DB 4.0 matches for EG886_RS06300

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06300_lanthipeptide

Lanthipeptides: EG886_RS06300_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDCR

50.0%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

GEVRPQSGPVCAV-TLAVCVPVSLAFCPTTACTSDC

GEV P + CA+ T+A S A CPTTAC+S C

GEVTPYTTWGCAIFTIA-----SAAQCPTTACSSKC

47.2%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V PQ+ P ++A + VS FCPTT CTS C

GDVDPQTTPS---SVACGIAVSALFCPTTKCTSQC

with 125 more sequence matches

Only the first 10 are displayed here.

44.4%

NC_018499.1and 5 others:

Lanthipeptides: BCK_RS27845_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P +AV SL CPTT CTS C

GDVNPETTPATPTIVAV----SLGICPTTKCTSKC

41.7%

NC_009328.1and 1 other:

NZ_PIJH01000018.1 Lanthipeptides: CV632_RS18055_lanthipeptide

Lanthipeptides: GTNG_RS18990_lanthipeptide

EVRPQSGPVCAVTLAVCVPVSLAFCPT

EV PQS VC V+L +C SL FCP+

EVSPQSTIVC-VSLRIC-NWSLRFCPS

41.7%

NC_018499.1and 1 other:

NC_018499.1 Lanthipeptides: BCK_RS27830_lanthipeptide

Lanthipeptides: BCK_RS27830_lanthipeptide

GEVRPQ--SGPVCAVTLAVCVPV-SLAFCPTTACT

G+V P+ S PV TL + VP+ + CPT CT

GDVNPEIMSDPV---TLTIVVPIFTNKLCPTVPCT

41.7%

NZ_CP006058.1and 25 others:

Lanthipeptides: BAMY6639_RS19790_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

+V P + P +L V V+ AFCP+T CTS C

ADVTPHTTPS---SLPCGVFVTAAFCPSTKCTSSC

41.7%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P T + V +S+ CPTT CTS C

GDVSPETTPA---TPTIVVAISVGLCPTTKCTSKC

41.7%

NZ_CP085411.1and 1 other:

NZ_CP085411.1 Lanthipeptides: LIT28_RS29915_lanthipeptide

Lanthipeptides: LIT28_RS29915_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P A V V +++ CPTT CTS C

GDVNPETTPTTATVTTVLVGATISVCPTTKCTSRC

41.7%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

CAVTLAVCVPVSLAFCPTTACTSDC

CAV AV VS + CPTT CTS C

CAVVTAVATLVSASACPTTKCTSQC

41.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

EVRPQSGPVCAVTLAVCVPVSLAFCPTTACTS

E++P+ P L V +P+SLA CPTT C S

EIQPKWTP-----LTVTIPISLAGCPTTKCAS

41.7%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P T + V +S+ CPTT CTS C

GDVSPETTPA---TPTIVVGISVGLCPTTKCTSKC

41.7%

NZ_QNUC01000031.1and 1 other:

NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23045_lanthipeptide

Lanthipeptides: DN396_RS23045_lanthipeptide

GEVRPQSGPVCAVTLAVCVPVSLAFCPTTACTSDC

G+V P++ P A V V +++ CPTT CTS C

GDVNPETTPTTATVTTVLVGATISICPTTKCTSRC

MIBiG 4.0 matches for EG886_RS06300

40.5%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

VCAVTLAVCVPVSLAFCPTTACTSDC

+ A+ V V VS AFCPTT CTS C

IVAIQAGVAVGVSAAFCPTTKCTSRC

38.9%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

SGPVCAVTLAVCVPVSLAFCPTTACTSDC

+GP+C S AFCPTT CTS C

TGPLCVAASVA---ASAAFCPTTKCTSKC

EG886_RS06305

Leader:

MSREIRMWKDPVFRLQSEGSMMEHPSGNVMEELREQDLLSVAGG

Core:

CDWWNISCHLGNTGRFCTLTKECQPNCNY

Core with dehydrations:

CysDWWNIDhaCysHLGNDhbGRFCysDhbLDhbKECysQPNCysNY

antiSMASH-DB 4.0 matches for EG886_RS06305

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCNY

89.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

CDWWNISCHLGNTG+FCTLTKECQP+CN

CDWWNISCHLGNTGQFCTLTKECQPSCN

69.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNC

C++WNISCHLGN G CTLTKEC+P C

CNFWNISCHLGNDGSVCTLTKECRPAC

with 102 more sequence matches

Only the first 10 are displayed here.

65.5%

NC_021362.1and 29 others:

Lanthipeptides: BALI_RS00925_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C+W+NISC LGN G++CTLTKECQ +C

CEWYNISCQLGNKGQWCTLTKECQRSCK

65.5%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

WWNISCHLGNTGRFCTLTKECQPNCN

WWN+S +LGN GR CTLTKECQ CN

WWNVSKNLGNKGRICTLTKECQSMCN

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C WWN+SCHLGN G++CT +KEC P CN

CSWWNVSCHLGNDGKYCTASKECMPTCN

62.1%

NZ_CP006058.1and 23 others:

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W++ISC LGN G +CTLT ECQ +CN

CAWYDISCKLGNKGAWCTLTVECQSSCN

62.1%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+++SC LGN G +CTLT ECQ NCN

CAWYDVSCRLGNKGAWCTLTVECQNNCN

59.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+NISC LGN G +CTLT EC P+CN

CAWYNISCRLGNKGAYCTLTVECMPSCN

58.6%

Lanthipeptides: allorf_075467_075682_lanthipeptide

CDWWNISCHLGNTGRFCTLTKECQPNC

C WW++SCHLGN G CTL+ EC+P C

CTWWDLSCHLGNDGSTCTLSVECRPAC

56.7%

NZ_AKXV01000031.1and 4 others:

Lanthipeptides: Y19_RS0109895_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN G +CTLTKECQPNCN

FSLSDFLGNQGGWCTLTKECQPNCN

56.7%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGNTG +CTLT ECQPNCN

FSLSDVLGNTGGWCTLTVECQPNCN

56.7%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN+G +CTLTKECQPNCN

FSLSDALGNSGGWCTLTKECQPNCN

MIBiG 4.0 matches for EG886_RS06305

65.5%

Lanthipeptide: haloduracin β or haloduracin α

CDWWNISCHLGNTGRFCTLTKECQPNCN

C W+NISC LGN G +CTLT EC P+CN

CAWYNISCRLGNKGAYCTLTVECMPSCN

56.7%

Lanthipeptide: birimositide

WNISCHLGNTGRFCTLTKECQPNCN

+++S LGN G +CTLTKECQPNCN

FSLSNALGNNGGWCTLTKECQPNCN

28.2%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTKECQPNCN

CTL+KECQPNCN

CTLSKECQPNCN

EG886_RS06310

Leader:

MNQLVRSWKDPLFRVQTEQNRMEHPSGNVLEELREQDLLSVAGG

Core:

CDWWNISCHLGNTGQFCTLTKECQPSCNR

Core with dehydrations:

CysDWWNIDhaCysHLGNDhbGQFCysDhbLDhbKECysQPDhaCysNR

antiSMASH-DB 4.0 matches for EG886_RS06310

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCNR

89.7%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

CDWWNISCHLGNTG+FCTLTKECQP+CN

CDWWNISCHLGNTGRFCTLTKECQPNCN

72.4%

NC_021362.1and 29 others:

Lanthipeptides: BALI_RS00925_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C+W+NISC LGN GQ+CTLTKECQ SC

CEWYNISCQLGNKGQWCTLTKECQRSCK

with 101 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSC

C++WNISCHLGN G CTLTKEC+P+C

CNFWNISCHLGNDGSVCTLTKECRPAC

65.5%

NZ_CP006058.1and 23 others:

Lanthipeptides: BAMY6639_RS13800_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W++ISC LGN G +CTLT ECQ SCN

CAWYDISCKLGNKGAWCTLTVECQSSCN

63.3%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C WWN+SCHLGN G++CT +KEC P+CN

CSWWNVSCHLGNDGKYCTASKECMPTCN

62.5%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+NISC LGN G +CTLT EC PSCN

CAWYNISCRLGNKGAYCTLTVECMPSCN

62.1%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

WWNISCHLGNTGQFCTLTKECQPSCN

WWN+S +LGN G+ CTLTKECQ CN

WWNVSKNLGNKGRICTLTKECQSMCN

58.6%

Lanthipeptides: allorf_075467_075682_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSC

C WW++SCHLGN G CTL+ EC+P+C

CTWWDLSCHLGNDGSTCTLSVECRPAC

58.6%

NZ_CP063276.1and 1 other:

NZ_CP063276.1 Lanthipeptides: IM743_RS02795_lanthipeptide

Lanthipeptides: IM743_RS02795_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+++SC LGN G +CTLT ECQ +CN

CAWYDVSCRLGNKGAWCTLTVECQNNCN

55.2%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00385_lanthipeptide

Lanthipeptides: CWT12_RS00385_lanthipeptide

ISCHLGNTGQFCTLTKECQPSCN

+S LGNTG CTLTKECQ CN

LSRKLGNTGYVCTLTKECQRMCN

55.2%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS17475_lanthipeptide

ISCHLGNTGQFCTLTKECQPSCN

+S LGN G+FCTLT EC PSCN

LSSLLGNDGKFCTLTVECMPSCN

54.8%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

CDWWNISCHLGNTGQFCTLTKECQPSCN

C WWN+SCHLGN G+ CT++ EC CN

CSWWNLSCHLGNNGKLCTVSHECAAGCN

MIBiG 4.0 matches for EG886_RS06310

69.0%

Lanthipeptide: haloduracin β or haloduracin α

CDWWNISCHLGNTGQFCTLTKECQPSCN

C W+NISC LGN G +CTLT EC PSCN

CAWYNISCRLGNKGAYCTLTVECMPSCN

53.3%

Lanthipeptide: birimositide

WNISCHLGNTGQFCTLTKECQPSCN

+++S LGN G +CTLTKECQP+CN

FSLSNALGNNGGWCTLTKECQPNCN

25.6%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTKECQPSCN

CTL+KECQP+CN

CTLSKECQPNCN

EG886_RS06325

Leader:

MKLTAREREVALLVACGYTDTEIAEELGV

Core:

SRRRICEIVSSIKFKWKTRSRVEIGIIVYYLGWIKEELSGKDLLSALR

Core with dehydrations:

DhaRRRICysEIVDhaDhaIKFKWKDhbRDhaRVEIGIIVYYLGWIKEELDhaGKDLLDhaALR

antiSMASH-DB 4.0 matches for EG886_RS06325

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06325_lanthipeptide

Lanthipeptides: EG886_RS06325_lanthipeptide

SRRRICEIVSSIKFKWKTRSRVEIGIIVYYLGWIKEELSGKDLLSALR

31.2%

NZ_CP012102.1:

Lanthipeptides: AC241_RS31270_lanthipeptide

IKFKWKTRSRVEIGIIVYYLGWIKEE

IK K K SRV+IGI+ Y+LGW+ E

IKSKCKISSRVKIGILAYHLGWLHFE

14.6%

NZ_CP101655.1and 1 other:

NZ_JAHHZH010000008.1 Lanthipeptides: allorf_106741_106917_lanthipeptide

Lanthipeptides: allorf_2707176_2707352_lanthipeptide

SSIKFKWKTRSRVEIGI

S++ F W TR + +IG+

STLGFFWNTRGKHKIGM

allorf_1264292_1264399

Leader:

MTNTPLLQDCFGA

Core:

NKDYYISKNYFKEFRVYLHFCV

Core with dehydrations:

NKDYYIDhaKNYFKEFRVYLHFCysV

antiSMASH-DB 4.0 matches for allorf_1264292_1264399

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1264292_1264399_lanthipeptide

Lanthipeptides: allorf_1264292_1264399_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

30.4%

NZ_CP024848.1:

Lanthipeptides: allorf_0212665_0212793_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

N D + KN++ F Y C

NMDTHQEKNFWTIFLSYTRICA

30.4%

NZ_PIOD01000016.1:

Lanthipeptides: allorf_242568_242714_lanthipeptide

NKDYYISKNYFKEFRVYLHFCV

N D + KN + F Y C

NMDTHQEKNLWTIFLSYTRICA

with 1 more sequence matches

27.3%

NZ_AP018254.1:

Lanthipeptides: allorf_3293275_3293364_lanthipeptide

FKEFRVYLHFCV

FK F ++LH C+

FKSFTIHLHVCL

MIBiG 4.0 matches for allorf_1264292_1264399

10.3%

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

FRVYLH

FRV H

FRVSSH

allorf_1271752_1271961

Leader:

MPAPADVVHAS

Core:

RLFSARLRVPFSAPLISAQHSVGRKKDLSLTLIAHETSCTLRSLRRQARASRRLTPLG

Core with dehydrations:

RLFDhaARLRVPFDhaAPLIDhaAQHDhaVGRKKDLDhaLDhbLIAHEDhbDhaCysDhbLRDhaLRRQARADhaRRLDhbPLG

antiSMASH-DB 4.0 matches for allorf_1271752_1271961

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271752_1271961_lanthipeptide

Lanthipeptides: allorf_1271752_1271961_lanthipeptide

RLFSARLRVPFSAPLISAQHSVGRKKDLSLTLIAHETSCTLRSLRRQARASRRLTPLG

8.6%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_250966_251172_lanthipeptide

RLFSARLRVPFSAP

+++++ R P+SAP

KVWNSTFRFPWSAP

allorf_1271778_1271840

Leader:

MHGLAGG

Core:

VSGVCTKFRARSE

Core with dehydrations:

VDhaGVCysDhbKFRARDhaE

antiSMASH-DB 4.0 matches for allorf_1271778_1271840

100.0%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: allorf_1271778_1271840_lanthipeptide

Lanthipeptides: allorf_1271778_1271840_lanthipeptide

VSGVCTKFRARSE

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 21.57 out of 23.79

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.48 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.93 out of 23.79

Confidence: medium

Additional weak hits (6):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.44 out of 29.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.08 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.09 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.92 out of 21.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.89 out of 29.65

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.87 out of 26.06

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

EG886_RS06300 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3510.7 Da

Molecular weight: 3513.1 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3531.1 Da N = 1; 3549.1 Da N = 2

EG886_RS06305 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 3333.4 Da

Molecular weight: 3335.7 Da

Number of bridges: 4

EG886_RS06310 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 3253.4 Da

Molecular weight: 3255.6 Da

Number of bridges: 5

EG886_RS06325 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 5568.2 Da

Molecular weight: 5571.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5589.6 Da N = 1; 5607.6 Da N = 2; 5625.6 Da N = 3; 5643.6 Da N = 4; 5661.7 Da N = 5; 5679.7 Da N = 6

allorf_1264292_1264399 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 2857.4 Da

Molecular weight: 2859.3 Da

Number of bridges: 1

allorf_1271752_1271961 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 6277.7 Da

Molecular weight: 6281.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6299.3 Da N = 1; 6317.3 Da N = 2; 6335.4 Da N = 3; 6353.4 Da N = 4; 6371.4 Da N = 5; 6389.4 Da N = 6; 6407.4 Da N = 7; 6425.5 Da N = 8; 6443.5 Da N = 9; 6461.5 Da N = 10; 6479.5 Da N = 11

allorf_1271778_1271840 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1384.7 Da

Molecular weight: 1385.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1403.6 Da N = 1; 1421.6 Da N = 2

EG886_RS06300 - Class II

Cleavage pHMM score: 3.80

RODEO score: 0

Monoisotopic mass: 3510.7 Da

Molecular weight: 3513.1 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3531.1 Da N = 1; 3549.1 Da N = 2

EG886_RS06305 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 3333.4 Da

Molecular weight: 3335.7 Da

Number of bridges: 4

EG886_RS06310 - Class II

Cleavage pHMM score: -1.60

RODEO score: 0

Monoisotopic mass: 3253.4 Da

Molecular weight: 3255.6 Da

Number of bridges: 5

EG886_RS06325 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 5568.2 Da

Molecular weight: 5571.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5589.6 Da N = 1; 5607.6 Da N = 2; 5625.6 Da N = 3; 5643.6 Da N = 4; 5661.7 Da N = 5; 5679.7 Da N = 6

allorf_1264292_1264399 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 2857.4 Da

Molecular weight: 2859.3 Da

Number of bridges: 1

allorf_1271752_1271961 - Class II

Cleavage pHMM score: -5.50

RODEO score: 0

Monoisotopic mass: 6277.7 Da

Molecular weight: 6281.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6299.3 Da N = 1; 6317.3 Da N = 2; 6335.4 Da N = 3; 6353.4 Da N = 4; 6371.4 Da N = 5; 6389.4 Da N = 6; 6407.4 Da N = 7; 6425.5 Da N = 8; 6443.5 Da N = 9; 6461.5 Da N = 10; 6479.5 Da N = 11

allorf_1271778_1271840 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1384.7 Da

Molecular weight: 1385.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1403.6 Da N = 1; 1421.6 Da N = 2

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism

NZ_CP034118.1 - Region 7 - NRPS,T1PKS

Download region SVG

Location: 1,892,700 - 1,950,663 nt. (total: 57,964 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EG886_RS09530: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase

EG886_RS09470: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase

EG886_RS09505: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

EG886_RS09525: thioesterase

smcogs: SMCOG1004: thioesterase

Isomerases: racemase

EG886_RS09495: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: ligase synthase

EG886_RS09540: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

EG886_RS09545: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

EG886_RS09550: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.69	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001164.3	0.65	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.68	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.67	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.66	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001164.3	0.66	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.75 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.64 out of 26.33

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 16.08 out of 18.57

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.13 out of 27.78

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.98 out of 23.79

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 20.11 out of 23.05

Confidence: medium

Additional weak hits (23):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 20.75 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.33 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.80 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.86 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.00 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.08 out of 21.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.52 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.05 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.54 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 19.06 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.93 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.31 out of 26.85

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.56 out of 25.88

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.27 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.42 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.63 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.01 out of 30.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.61 out of 26.33

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 20.37 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 1892699 - 1950663:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - Cys) + (mal - Cys) + (Ser)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EG886_RS09540: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (464..870): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LGAHFDVSVWEGNQVFAGEINMYGITEITVHATF
Nearest Stachelhaus code(s):: Ser DVWNVAMVHK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

EG886_RS09545: mal - Cys

Search NORINE for peptide: strict or relaxed

PKS_AT (536..832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 181.9
inactive: 121.0
Methoxymalonyl-CoA: 76.7
Methylmalonyl-CoA: 73.1
Propionyl-CoA: 61.1
Ethylmalonyl-CoA: 47.4
2-Methylbutyryl-CoA: 39.3
Isobutyryl-CoA: 36.9
CHC-CoA: 30.4
Benzoyl-CoA: 28.5
fatty_acid: 20.0
trans-1,2-CPDA: 15.4
Acetyl-CoA: 11.4
3-Methylbutyryl-CoA: 0.0

AMP-binding (1494..1893): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTMMSGDWSLGGATEASIWSIH
Nearest Stachelhaus code(s):: Cys DLYNMSLIWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

EG886_RS09550: NH2 - Cys

Search NORINE for peptide: strict or relaxed

CAL_domain (43..490): NH2

minowa: NH2

Prediction, score:

NH2: 35.7
fatty_acid: 22.3
AHBA: 21.4
shikimic_acid: 6.7
Acetyl-CoA: 1.1

AMP-binding (1154..1550): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNTMMSGDYGLGGATEASIWSIH
Nearest Stachelhaus code(s):: Cys DLYNMSLIWK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AfsR	Pleiotropic regulatory for antibiotic production
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_CP034118.1 - Region 8 - RiPP-like

Download region SVG

Location: 2,099,298 - 2,110,149 nt. (total: 10,852 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002545.3	0.24	PKS	sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G	Micromonospora sp.
BGC0000207.5	0.23	PKS	chartreusin	Streptomyces chartreusis
BGC0000652.5	0.23	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0001079.5	0.22	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0002688.2	0.22	NRPS	benarthin, dibenarthin	Planobispora rosea
BGC0002477.3	0.22	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000392.5	0.21	NRPS	mirubactin	Actinosynnema mirum DSM 43827
BGC0000235.5	0.21	PKS	kiamycin	Streptomyces sp. W007
BGC0000842.5	0.21	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000219.4	0.20	PKS, saccharide	elloramycin	Streptomyces olivaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002545.3	0.24	PKS	sungeidine C, sungeidine B, sungeidine D, sungeidine H, sungeidine A, sungeidine E, sungeidine F, sungeidine G	Micromonospora sp.
BGC0000207.5	0.23	PKS	chartreusin	Streptomyces chartreusis
BGC0000652.5	0.23	terpene	napyradiomycin	Streptomyces sp. CNQ525
BGC0001079.5	0.22	PKS, terpene	napyradiomycin A80915C, napyradiomycin 2, napyradiomycin 3, napyradiomycin 4	Streptomyces aculeolatus
BGC0002688.2	0.22	NRPS	benarthin, dibenarthin	Planobispora rosea
BGC0002477.3	0.22	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000392.5	0.21	NRPS	mirubactin	Actinosynnema mirum DSM 43827
BGC0000235.5	0.21	PKS	kiamycin	Streptomyces sp. W007
BGC0000842.5	0.21	other (non-nrp beta-lactam)	carbapenem MM4550	Streptomyces argenteolus
BGC0000219.4	0.20	PKS, saccharide	elloramycin	Streptomyces olivaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (8):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.65 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.45 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.17 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.93 out of 29.38

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.74 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.16 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.57 out of 26.33

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.40 out of 26.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ZuR variant 1	Zinc-responsive repressor

NZ_CP034118.1 - Region 9 - azole-containing-RiPP