LOCUS       NZ_ML123034            26316 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun
            sequence.
ACCESSION   NZ_ML123034
VERSION     NZ_ML123034.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. ADI96-02
  ORGANISM  Streptomyces sp. ADI96-02
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Streptomyces spp. from the marine sponge Antho dichothoma: analyses
            of secondary metabolite biosynthesis gene clusters and some of their
            products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003846185.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 03:48:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,089
            CDSs (total)                      :: 6,032
            Genes (coding)                    :: 5,843
            CDSs (with protein)               :: 5,843
            Genes (RNA)                       :: 57
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 68 of 189
            Pseudo Genes (incomplete)         :: 155 of 189
            Pseudo Genes (internal stop)      :: 10 of 189
            Pseudo Genes (multiple problems)  :: 42 of 189
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6355314
            Orig. end                         :: 6381630
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            ML123034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, Department of
            Pharmacognosy, University of Vienna.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
FEATURES             Location/Qualifiers
     region          1..26316
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="26"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..26316
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26316
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:16316](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..16316
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(556..574)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            1121..2281
                     /locus_tag="EES43_RS27805"
                     /old_locus_tag="EES43_27445"
     CDS             1121..2281
                     /EC_number="2.7.8.-"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612939.1"
                     /locus_tag="EES43_RS27805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27445"
                     /product="MraY family glycosyltransferase"
                     /protein_id="WP_124271308.1"
                     /sec_met_domain="Glycos_transf_4 (E-value: 6e-20, bitscore:
                     70.3, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVLGIIASAVAALFITAVLAKGVHRTVLRSRPAPEGPGRGPRAR
                     KLRKLGGAALALGTGAVVAAAWALGPDGSAGTVGALLAGAGTVAALGLVHDLRPLPFAL
                     RLTVQAAAATLVAHLAGLSPAAALPAVLWIVLVTNAFALLDNSDGLLPAVAVVTAGGLF
                     TCAAVDGRLVLGLFPAALAAGSVGLLLHSWHPARVHLGSTGALFTGFALASCGALIQFH
                     APQGRTAWAALPLLATVALADSALVLISRRRAGRPLVRGGGDHIAHRLRRLRVTVPGAA
                     VVMVLWALVPVLAATLVYAGTLHPAFLLAVPLASGAAVAALLRVPVYAAAPRGAAARGT
                     ASRPTAFPPAARTAPGSAVPLGTATANPTVPPPTGRPSAGITADRR"
     gene            2479..3450
                     /locus_tag="EES43_RS27810"
                     /old_locus_tag="EES43_27450"
     CDS             2479..3450
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010058996.1"
                     /locus_tag="EES43_RS27810"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27450"
                     /product="metallophosphoesterase"
                     /protein_id="WP_124271309.1"
                     /transl_table=11
                     /translation="MTAPSDPAPSGVPSAAVPPPGGSAPSAGGRLLAVSDLHAAVTDNR
                     PLVESLRPTSAEDWLIVAGDVAERPDDIRWALGLLAERFARVIWTPGNHELWTLDKDPV
                     RLRGQARYAHLVELCRDLGVTTPEDPFPVWTGPGGPVAVAPLFLLYDYTFRAPGTHTKE
                     ESLAAAHGTGIVCNDEYLLHPDPYPGRDDWCRARVAETERRLAGHDPGLPLVLVGHWPL
                     VREPTSVLWYPEFAQWCGTELTADWHRRFNVAAVVYGHLHIPRTTWYDGVRFEEVSIGY
                     PREWRERGHPRGLLRQILPYDEDPGRTAGGPSAERFAEGGPS"
     gene            3447..4145
                     /locus_tag="EES43_RS27815"
                     /old_locus_tag="EES43_27455"
     CDS             3447..4145
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612943.1"
                     /locus_tag="EES43_RS27815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27455"
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_124271310.1"
                     /transl_table=11
                     /translation="MIERLLPGYVSCASTRAVSVPDHTLFPEEEALIARSVAKRRNDFA
                     TVRACARRAMAGLGLEPVAVLHGTRGMPLWPEGFVGSLTHCEGYRAAALAHGTDVLSLG
                     IDAEPHAPLPSGVHELVTLPSERERLAGWEPDGVHGIHGDRLLFSAKESVFKTWYPVTR
                     IELDFHEADLTFHRPEPGASEGTFTARLLRTDPALPSTLEGRWLVEEGIVATAVLVTPS
                     WRGSGGPALP"
     gene            complement(4261..4938)
                     /locus_tag="EES43_RS27820"
                     /old_locus_tag="EES43_27460"
     CDS             complement(4261..4938)
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612944.1"
                     /locus_tag="EES43_RS27820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27460"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_124271311.1"
                     /transl_table=11
                     /translation="MTVRVMLISPAMNAALREARFDGDAPLDRSGERQARAAADAVPVA
                     SRALCGPSERCLGTATALGLAARPEQALAGWNLGRWSGLRLDAVGAAEPAGVAAWLGDP
                     SAAPHGGETLRALVERVGGWLEALDGDRPGGDGRHRPSGDDGPGADGPSGAANGPPTAR
                     DRSVVAVVEPAIVRSAVVHALRLPVEVFWRLDVGPLVLTELSGRRERWNVRLGRPLTVP
                     QDT"
     misc_feature    5045..5065
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.28"
                     /tool="antismash"
     regulatory      5078..5145
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    5201..5211
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            5205..5420
                     /locus_tag="EES43_RS27825"
                     /old_locus_tag="EES43_27465"
     CDS             5205..5420
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003950971.1"
                     /locus_tag="EES43_RS27825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27465"
                     /product="CbtB-domain containing protein"
                     /protein_id="WP_124271312.1"
                     /transl_table=11
                     /translation="MAQSAAPTTGAPAFTPISAKAIAPWAVFFGILMLVLLYFVGAEQG
                     ATALISGEGVHEWVHDGRHLLGFPCH"
     gene            5468..6223
                     /locus_tag="EES43_RS27830"
                     /old_locus_tag="EES43_27470"
     CDS             5468..6223
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015612946.1"
                     /locus_tag="EES43_RS27830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27470"
                     /product="CbtA family protein"
                     /protein_id="WP_124271313.1"
                     /transl_table=11
                     /translation="MNSISVRALLVRGMLAGLIAGALALVVAYFLGEAQVDAAIALEEA
                     NSHDHGGGEELVSRTMQATGGLATGVLVFGVAAGGIAALVFCYALGRLGTFGPRATAAL
                     VAGAALLTVYVVPFLKYPANPPAVGNPDTIGQRTALFFLMVALSVLLGVAAVIIGKRLA
                     PRLGNWDATIAASAGFVLAVGLAYAFLPSFDEVGKDFPASLLWEFRLSTLAVQTTLWSV
                     FGLVFGYLTERLLVPGNGPAVPRAASTVG"
     gene            complement(6410..6769)
                     /locus_tag="EES43_RS27835"
                     /old_locus_tag="EES43_27475"
     CDS             complement(6410..6769)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019761604.1"
                     /locus_tag="EES43_RS27835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27475"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_124271314.1"
                     /transl_table=11
                     /translation="MNDTYYEFGTAADRWDRAQMFFEAKEYLTAARILGGLVEEAPEQV
                     APRLLLARSYYHSARLGRAEEELRAVLDIDPVESYARLMLGRTLERQGRGAEAASHLRI
                     AAALTGDFGSGADRQ"
     misc_feature    complement(6848..6865)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.69"
                     /tool="antismash"
     misc_feature    complement(6909..6927)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.72"
                     /tool="antismash"
     misc_feature    6919..6933
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 16.84"
                     /tool="antismash"
     gene            6919..7884
                     /locus_tag="EES43_RS27840"
                     /old_locus_tag="EES43_27480"
     CDS             6919..7884
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1208: pirin
                     domain-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010059009.1"
                     /locus_tag="EES43_RS27840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27480"
                     /product="pirin family protein"
                     /protein_id="WP_124271315.1"
                     /transl_table=11
                     /translation="MSNLDRQATPSVCGGRGFVVAEPVRELLSPRHVPLGEGTEVRRLL
                     PNLGRRMVGAWAFVDHYGPDDIADEPGMQVPPHPHMGLQTVSWLHDGEVLHRDSLGSLQ
                     TVRPRELGLMTSGRAISHSEESPKPHARLLHGAQLWVALPDEHRNVEPHFQHHADLPTV
                     TAPGVGATVILGELDGAVSPGTAYTPIVGADLALARGAEARLPLEPDFEYAVLSMSGEA
                     EVDGVRVLPGSMLYLGCGRTELPLRAASDAGLMLLGGEPFAEEIVMFWNWIGRSQEEVA
                     QARHDWMNGTRFGEVKGYDGPSIPAPELPAVPLKARGRVR"
     misc_feature    complement(8013..8022)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            8371..>8721
                     /locus_tag="EES43_RS27845"
                     /old_locus_tag="EES43_27485"
                     /pseudo=""
     CDS             8371..>8721
                     /GO_function="GO:0008661 - 1-deoxy-D-xylulose-5-phosphate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0016114 - terpenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018838697.1"
                     /locus_tag="EES43_RS27845"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27485"
                     /product="1-deoxy-D-xylulose-5-phosphate synthase
                     N-terminal domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="DXP_synthase_N (E-value: 1.6e-43,
                     bitscore: 147.3, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMPESIDGPAALRSLPPALLPAPAAEIRSFLVEKVSATGGHLGP
                     NLGVVELTMALHRVFDVEEGDVLLFDTGHQTYVHKLLTGRRAGSDGLRQEGGLSGYPGR
                     GESAHDWIENSHA"
     gene            8865..10004
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /locus_tag="EES43_RS27850"
                     /old_locus_tag="EES43_27490"
     CDS             8865..10004
                     /EC_number="1.17.7.1"
                     /GO_function="GO:0046429 - 4-hydroxy-3-methylbut-2-en-1-yl
                     diphosphate synthase activity (ferredoxin) [Evidence IEA]"
                     /GO_process="GO:0044237 - cellular metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ispG"
                     /gene_synonym="gcpE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349429.1"
                     /locus_tag="EES43_RS27850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27490"
                     /product="flavodoxin-dependent
                     (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase"
                     /protein_id="WP_124271317.1"
                     /transl_table=11
                     /translation="MTAVDLPQPTVPSPAHTPARRRRTRQVRVGDVLVGGDAPVTVQSM
                     TTTPTADVDATLQQIARLTAAGCDIVRVAVPSQDDADALHRIAAKSKLPVIADIHFQPK
                     YVFQAIDAGCAAVRVNPGNIRKFDDKVREIAEAATAAGIPIRIGVNAGSLDERVLNRHG
                     AATPQALAESALWECALFEEHGFTDLKISVKHHDPLTTIAAYRHLAARCDYPLHLGVTE
                     AGPPPQGTIKSATAFAILLNEGVGDTIRVSLTAPPVEEVKAGIQILQALGLRPRQLEIV
                     SCPSCGRAQVDVYRLTAKVQAAFEGFPHPLRVAVMGCVVNGPGEAREADLGVSCGNGKG
                     QIFIRGRVVRTVPESQIVEALLEEALNVTETASAPGGAQ"
     gene            10001..11071
                     /locus_tag="EES43_RS27855"
                     /old_locus_tag="EES43_27495"
     CDS             10001..11071
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006349428.1"
                     /locus_tag="EES43_RS27855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27495"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_241192550.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 7.9e-50, bitscore:
                     168.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALAASPAAPLDPDDMRRTVDAVLYAFLDEQEQAAPDLPEIALF
                     TGMLRTMLAAGGKRVRPFLCLTGWAAITDQPPPPAVWRMAASLELFHAFALIHDDIMDR
                     SDTRRGRPTAHRALASHHAHRADADALGVNTAILLGDLALGWSYELLHVKDARLRRTWG
                     PLNALRTETLIGQYLDLTATGDPTAEADTAWRIIRYKTAKYTIERPLCLGAVTAGADPA
                     RLRSLSAYAIPLGEAFQLRDDLLGVYGDPARTGKSTLDDLREGKHTVLVATALDRATPA
                     QRRTLTSLLGDPSLDQETADVLRAVLTATGAAAAVEQMITDRFHAAERALDGSALRTHA
                     TTALRRLAASTATRAS"
     gene            11336..12433
                     /locus_tag="EES43_RS27860"
                     /old_locus_tag="EES43_27500"
     CDS             11336..12433
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="EES43_RS27860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27500"
                     /product="terpene synthase family protein"
                     /protein_id="WP_124271318.1"
                     /sec_met_domain="T1TS (E-value: 1.4e-66, bitscore: 224.1,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEIPDTTTSQLLHVPPLYCPIGAAVHPELDSINRDSRIYLDRYH
                     LHTSDIDRAWVIARNYAEAMARIYPEGITDRVALTARWLHWIFYVDDVRMETATTPDKL
                     ASAIGLTSHLLRVMESPATEPTADQTGPVAALQSLMTSVQAVATPTQLHRFVDAHRKWF
                     HAILWGMAAPALSSLDEFVHQRMLNAGGAASLCWSEITTGEEIPGDEFHSPAMRALQES
                     SFLMMALDNDLLSYNRERLIDGTKLNIVMLLARLNDCPPEQAIHQAVALRDRLTTLFLR
                     LREQEHPKLSAPGRAYVADLGYAIRSNLDWGSHSARYTVVAPRTQLPPENPAPIPLTLT
                     DHPGDPSTEPLPCPSIAWWWQQLRT"
     gene            complement(12505..13941)
                     /locus_tag="EES43_RS27865"
                     /old_locus_tag="EES43_27505"
     CDS             complement(12505..13941)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="EES43_RS27865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27505"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_164493294.1"
                     /sec_met_domain="DAO (E-value: 3.5e-07, bitscore: 28.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKERAGHGRAEHAADRQRPPEVSHGSWGHAVVIGAGFTGLLTARV
                     LAGRFDRVTVLERDELPSGPAHRSGLPQARHPHGLLARGALIVEDLFPGVRAELAAQGA
                     PVFDFGAGFATRLPYGWAPRRSVGIEVQSFDLTDLEAVLRARVRALPGVRVRDGFVVEG
                     LHLSADRRRTVGVTGHHRADPGHKPVRIEADLVVDAAGRRSRLPGWLAAAGLPAPRRLE
                     VPSPLVYSSRMYELTDGQAPDWLVAFEMTLPPSVDRGGAAITVDGTRRLISLVAPAEEL
                     PPPRDDEALQRFAATLRSPHFAEVMARGRPVSPVYRCVVGGNHWLRYDRLRGCPDRLLV
                     VGDAFCAFNPVYGQGLTVAALQARLLARLLATADGPSGLAHRFQRRAARIALVPWLTAT
                     AADGGWSSEPTGRPARMIRGFLDVVLRRLPDEPELYARFARVQNMVASPAVLLRPLLAR
                     PGRRGRRAARTRLSGPSRDR"
     gene            complement(13962..15161)
                     /locus_tag="EES43_RS27870"
                     /old_locus_tag="EES43_27510"
     CDS             complement(13962..15161)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="EES43_RS27870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27510"
                     /product="cytochrome P450"
                     /protein_id="WP_124271320.1"
                     /sec_met_domain="p450 (E-value: 8e-18, bitscore: 62.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTSDGCPVFPSPQDPSADHDISGAALLGEGPVAAAVMADGAPIH
                     LALSHEAVRQVLIDPRFSRAEASRPGVPSVVPFHAQNGLLHAMDPPEHTALRAHIGRAF
                     TARTVERLRPEIEALVAEMLDAMEAAGPPADVVAHLTAPLPVKVLCRLLGVPYEDHDAF
                     REWIEAILPASAGSAGEAATAAEQLTTYLQELIGAKRRAPGDDLISTLLAPGPDGLPLD
                     DATVLANLIPVLVAGHDTTHNQLSNSLVALFAHREQWDLLVRSPELVPRAVDELLRHQL
                     LSRVGMLMRVTTAEVDLLGVTLPPGTAVNALNCVANRDPAVFSEPDRLDIRRPDAGKHL
                     AFGAGPHYCPGGQLARLELSIALLALVRRFPALRPAVPVEELDWKDGIMRGPWQLPVAW
                     "
     gene            15345..16316
                     /locus_tag="EES43_RS27875"
                     /old_locus_tag="EES43_27515"
     CDS             15345..16316
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="EES43_RS27875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27515"
                     /product="hypothetical protein"
                     /protein_id="WP_124271321.1"
                     /sec_met_domain="T1TS (E-value: 1.8e-58, bitscore: 197.4,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEPLLVPDLYCPFPRAARPHADTVEREVVAWMERFELIRTPAER
                     ERLSGIRIGWLTGAAHADGLLEPSIIAAQLTAWLTAFDDRYADCPRPDEQGVPTARLVL
                     RLRAVMEDPAAAPAPDEPYCAGLRDLFLRLAAWAGPEQLMRVRSSMTEYFMSALCQVTY
                     GLGAYTPTFDEYVELRRYTGICHIVFTLVDVARGFELPGAVWAGPEVRALNTAAADVID
                     YANDVLGSRKEFTHEDDLARSLPQVLAQQYGCDHAEALRRAAAIHDEAVRAFMALASEV
                     RLAADPLLARYIAGLETWMVAHFDWYGVTNRYDSHREQVRWA"
     gene            16390..17157
                     /locus_tag="EES43_RS27880"
                     /old_locus_tag="EES43_27520"
     CDS             16390..17157
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1195: IclR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF020897.4"
                     /locus_tag="EES43_RS27880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27520"
                     /product="IclR family transcriptional regulator C-terminal
                     domain-containing protein"
                     /protein_id="WP_124271322.1"
                     /transl_table=11
                     /translation="MTYALDARPRQAAEQAPGAAEKALLLLESLTALSAAGVPPTLTGL
                     ATASGLAKSTTHRLLSLLVRRGMVTCTDGAYRPGPALAGLAAAALGLPVDRLRSTLLPH
                     MVDLYELTHETVNLAVLQGPDIVLIERVHGSRTQRSSVRLPERVPAHSTALGRALLDAA
                     GTSATAPPHAGVPGDRTGVLLSEIRRQGMSTSLGELIPGVACLALPILDEARNPVMALS
                     VSGWAQSMNLLSTAKHLRSVSLAAGLALLTEED"
     misc_feature    16678..16680
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            17298..17804
                     /locus_tag="EES43_RS27885"
                     /old_locus_tag="EES43_27525"
     CDS             17298..17804
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014152328.1"
                     /locus_tag="EES43_RS27885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27525"
                     /product="hypothetical protein"
                     /protein_id="WP_124271323.1"
                     /transl_table=11
                     /translation="MKRTATVVTCVAAFLFTTALTGCSSGSGDASGEGEGHGPVSSSAS
                     PSKPATVDTKSAGKLGTILVDDKGRTLYLFLADKKNKSNCSGACAKAWPPLLTKGDAKP
                     GKGVEKKLLDTTKRSGGGTQVTYNGHPLYYYVGDSKPGQTNGQDLDQFGAEWYVLNAKG
                     KQVGS"
     gene            17873..18412
                     /locus_tag="EES43_RS27890"
                     /old_locus_tag="EES43_27530"
     CDS             17873..18412
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018834020.1"
                     /locus_tag="EES43_RS27890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27530"
                     /product="DUF6529 family protein"
                     /protein_id="WP_124271324.1"
                     /transl_table=11
                     /translation="MLALLGVLLPVAVGVGIYFFGTHHTPDYDSGLYGEHGAAAVDLKA
                     RLGSALLCLALIQLVLALWMYGRVPGARSAPRSVRLGHRVLGFLTFLFSLPIAYHCLET
                     YGIETTSPRTAIHSFAGCALYGAFVAKVIVVRSRRLPGWMLPVMGSLLVLGVALLWYTA
                     ALWVLNGDSVPGFSES"
     gene            complement(18440..20011)
                     /locus_tag="EES43_RS27895"
                     /old_locus_tag="EES43_27535"
     CDS             complement(18440..20011)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_function="GO:0030246 - carbohydrate binding [Evidence
                     IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012762.4"
                     /locus_tag="EES43_RS27895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27535"
                     /product="cellulose binding domain-containing protein"
                     /protein_id="WP_124271325.1"
                     /transl_table=11
                     /translation="MSKSLVPPPATSRSLDASAPATPFIGRRLWDDESDPVDTYARLCT
                     RTSTAAEALAARAGERTRASRQLEPSWAEELPTVPAALNTVLIVAMEMSSSPEEARVLA
                     PDLLNRLTEHAADPGAEPWDPWASAETSLALRALCAMDPDDSELLWWSCVEGLPDTVVA
                     ERLDRPRAETAADLVRVTESFRERSSLIHRAQVQDPVCRSYASLLDAAARGSAPTTPPD
                     LLEHLNGCLVCGTAFECLSRADDVLPGLVAEATLKWSGPAYVARRRRQLSQQPNGAEVR
                     PSRSVRPAGRRVLPGGTEGRTTGSSAGRSRLMKAAGIGTGLVLLGGGMLVLHDASQQDA
                     RPASSLLRPGVQRELPGSGAPDDAPEVSRKPGGPDRSATADPSASAPAEDRETVSPSPS
                     DRTPEEDEDKPSRPPSQACSADVRIRNQWNEGIEADLNITSDTALEAGWKLTFRVPDKA
                     RVQVWNGTATTTGDLVTVTAADYNRTVPSRGTLSVGVVVDFAYDDAYAPAAWVSDARVD
                     GRTCPL"
     misc_feature    complement(20059..20073)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.18"
                     /tool="antismash"
     gene            complement(20781..22271)
                     /locus_tag="EES43_RS27900"
                     /old_locus_tag="EES43_27540"
     CDS             complement(20781..22271)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016497.4"
                     /locus_tag="EES43_RS27900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27540"
                     /product="family 43 glycosylhydrolase"
                     /protein_id="WP_164493295.1"
                     /transl_table=11
                     /translation="MNLRARATRLTTLTAAVALAFTGGLALPAHAAGPSSVIANDTAWT
                     DTDGNEILAQGGNVLKVGSIYYWVGQKLVSGQPKTINLYSSTDLENWTYEGPVLSQSGS
                     EGPLAEGLWLGRPQLIRNPDGKFVLVVEVNDGDRNRNQILFATSPTIDGTYTPTGPAKE
                     INGNTTGDHSVFVDGDKAYLVYVGDTGRGDAKSFNVTLNVAPLTGDWTGVGPAVYSESY
                     AHKEAPAIVKDNGTYYLFASGMDYWDATATSYRASSTLGGWDKAAPWSTVATRPSSDNS
                     FGTQFEQIIPVVGSKGTSYLYNGDRYSQFYKPGGSPAPGGIGRNAWYPLTFEGSGPVLH
                     GYTDVDVDAAAGTITGNRVANGRFDQDIAGTRVPQWKVTGPGKVEESTLGDGRRQLAVW
                     DDAAYTSWISQEVALPNGSYELSFDYRSSGGQKSAYVEVKGHGGSAVPVHLTAKQDTWA
                     TKKLTFTVSSGKVNLGIWSDSPAGKWLNIDNVSIWSAG"
     misc_feature    complement(22297..22310)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.23"
                     /tool="antismash"
     misc_feature    22299..22312
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 15.98"
                     /tool="antismash"
     misc_feature    complement(22300..22313)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.72"
                     /tool="antismash"
     misc_feature    complement(22302..22318)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     misc_feature    complement(22304..22317)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.55"
                     /tool="antismash"
     misc_feature    22305..22318
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.13"
                     /tool="antismash"
     misc_feature    complement(22306..22315)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.91"
                     /tool="antismash"
     misc_feature    complement(22344..22359)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.73"
                     /tool="antismash"
     gene            22560..23357
                     /locus_tag="EES43_RS27905"
                     /old_locus_tag="EES43_27545"
     CDS             22560..23357
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018837989.1"
                     /locus_tag="EES43_RS27905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27545"
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_346774335.1"
                     /transl_table=11
                     /translation="MAPIVYTAGLSLFQERLIGGVTFVGLDNYGEQLSDPRFWDGVARV
                     GLFLLIQVPLMMGFALGAALALDSARLYAPAIFRLGIFLPYAVPGVVASLLWGYIYGAQ
                     FGLVGDLKELFDIALPDPLSSTLILPSISNIGLWLYVGYNMLVLYAALQSIPSELFEAA
                     RIDGAGTWHIIVGIKLPAIRATLVFTTIFSVIGGFQLFNEPNILRAMVPNVISTDFTPN
                     MYAYTLSFAGQQYNSAAAVAMIMGVVTAVVAFTVQRRGMKGAV"
     gene            23354..24310
                     /locus_tag="EES43_RS27910"
                     /old_locus_tag="EES43_27550"
     CDS             23354..24310
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324160.1"
                     /locus_tag="EES43_RS27910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27550"
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_241192551.1"
                     /transl_table=11
                     /translation="MMLTQDKSPDVGRTAAPSQERAEPRRAVVRRREPREKPRRQRSVA
                     LTVLMTLPLLYSLFPLVWLVMNSTKSLDDLFSSFGLWFGDDFALWDNVVGVLTYDDGIY
                     GRWFANTLFYVALGAGGSTLLAALAGYGLAKFDFPGRRAALAVVLGAVAVPGTALAVPT
                     FLLFSQMGLTNTPWGVLIPLLVTPFGLFLLFSYANEAVPNEVLDAARVDGAGEFRIFFT
                     IVMRLLSPALVSVFLLEVVGAWNNYFLPLIMLSDPSWFPLTVGLNRWNAQGASAEGELI
                     ANLVLTGSLMTIVPLVIVFLFLQRFWRAGLAAGSTKG"
     gene            24446..25786
                     /locus_tag="EES43_RS27915"
                     /old_locus_tag="EES43_27555"
     CDS             24446..25786
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019324159.1"
                     /locus_tag="EES43_RS27915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_27555"
                     /product="sugar ABC transporter substrate-binding protein"
                     /protein_id="WP_241192552.1"
                     /transl_table=11
                     /translation="MNRWSRHRRTTSLLLGSVLTAVTVTACGGGAQGGSEPESVSEKEI
                     RAALEKPTELTVWSWSGSLPDVAEAFEKKYPKVKIKVENVGTAAEQYTKLQNAIKAGKG
                     APDLATVEYSAIPQYALSGALVDLKRFGFDSLKDEFTPATWDSVNVGDGLYELPLNAGP
                     MALFYNKKTFDKFDIAVPTTWDEYLEAGKKLQKADPEYFISADNGNAGLTESLIWSAGG
                     RPFKADGEKITVDLQDAGSKKYAESYQKLLDAKVLSGVAGWSNEWFQGLADGKIATLTS
                     GAWMAGILKGSVAKASGDWRVAPMPSYDGETTTSVNGGGSLAMTEQSDKKLAAAAFLRY
                     VSAEEGADITQATGSFPARAKALAAEKFLGAEDEYFGGQEVNRVFADSLAAVGEGWQYL
                     PYDVYAITIFNDKVGKAYTGEKTLQDGLNAWEQELLKYGKDQGFSVN"
     assembly_gap    26068..26092
                     /estimated_length=25
                     /gap_type="within scaffold"
                     /linkage_evidence="paired-ends"
ORIGIN
        1 gctcccagat caccacggtc aagccctacc tggcggcgct gcgccgcatg gtcgggctga
       61 tggcccgcat ccgcgacacg cacggagtcg tcctgcggga gctggacatg ggaggcgggc
      121 acggcatcgc ctaccgcccc ggcgaacgcg ccctcgaccc gaccgccctg gcccgccggc
      181 tgcggctcga actcgtcgag agctgcgccg ccgcggacct gacggtgccg cgtctgctca
      241 tcgaacccgg gcgggccgtg gccggcccgg ccgccgtggc gctctaccgc gtgctcgcgg
      301 tgaagcgcac cggcgagaag gtgttcgtcg ccgtcgacgg cgggatgagc gacaaccccc
      361 ggcccgcgct gtacggcgtg cgctacgcgc cccgcctcgt cgggcgccgt tcgtcggccg
      421 gcacggccgc cgccaccgtc gtcggccggc actgcgaggc gggcgacatc ctggcggccg
      481 atgtgcaact gccgggcgac atccaccccg gcgacctcct cgccgtaccg gtcgcgggcg
      541 cgtaccagct ctccatggct tccggataca acctggtggg ccggccgccc gttgtcgcgg
      601 tgcgcgacgg cacggcacgg ctgctcgtcc ggcgcgagac gctggaggac ctgcgcggca
      661 gggacatcgg ctgagcggag cctccgcgat caacctccct gacgcgatcg ctcacgcttt
      721 cgcgaccaac caccctcgac cacaggcccg ttgaacgggc ccggcgacaa ccggcagtgc
      781 cggtggggga tcgagtgcgg caccgggcga cccggtgccg cactcgcgcg tgtcggcgtc
      841 tcggtgaacg gcccggcgtg cgcccgcaga cgggcggcgc ccgcgtgtcg ttcgcgggcc
      901 tcttccggcc gctcgcggag gaaagcccaa acaatacgct tcccttttcg tgttatttgg
      961 ggtgaatgag gcatttgacc cgtaggttgg ggagaaacgc cacccgagcg gcatcacgtg
     1021 tcaccgggac accgcacccg ccgggacacc gcacggcccc gtatccaccg gccacccggc
     1081 gtcccgcgcc gcagatcacg actgaggaaa ggcagggcag gtgaacgttt tggggatcat
     1141 cgcctccgct gtggccgcgc tgttcatcac ggccgtactc gccaagggcg tccaccgaac
     1201 ggtgctccgc tcccgcccgg cgcccgaggg gcccggtcgc ggaccgcgcg cccgcaagct
     1261 cagaaagctg ggcggcgcgg ccctcgccct cggcaccggc gcggtcgtgg ccgccgcctg
     1321 ggcactcggc ccggacggct ccgccggcac ggtcggcgcg ctgctcgccg gagccggaac
     1381 cgtcgccgct ctcggactcg tccacgatct gcgacccctc ccgttcgccc tgcgcctgac
     1441 cgtccaggca gccgccgcga ccctggtcgc ccacctcgcg ggactgtccc cggcggcggc
     1501 gctgcccgcc gttctctgga tcgtcctcgt caccaacgcc ttcgccctcc tggacaactc
     1561 cgacggcctt ctgcccgccg tcgccgtcgt cacggccggc gggctgttca cctgcgccgc
     1621 cgtcgacggc cggctcgtgc tcggcctgtt cccggcggct ctggccgccg ggtcggtcgg
     1681 cctcctgctc cactcctggc accccgcacg cgtccatctc ggctccacgg gcgcgctgtt
     1741 caccggattc gcgctcgcct cctgcggcgc gctgatccag ttccacgctc cgcaggggcg
     1801 caccgcgtgg gcggcgctgc ccctcctggc gacggtggcc ctcgccgaca gcgccctggt
     1861 gctgatctcg cgccgccgtg ccggacgccc cctggtgcgc ggcggaggcg accacatcgc
     1921 ccaccgcctg cgccggctcc gcgtcaccgt tcccggagcg gccgtggtca tggtcctgtg
     1981 ggccctcgtg ccggtgctgg ccgcgaccct ggtgtacgcg gggacgctgc acccggcctt
     2041 cctcctcgcc gtcccgctcg ccagcggcgc ggccgtcgcc gccctgctgc gcgttccggt
     2101 gtacgccgcc gcgccgcgcg gcgcggcggc ccgggggacg gcctcccggc cgacggcgtt
     2161 tccgcccgcg gcgcggaccg cgccgggcag cgcggtgccc ctcggcacgg cgacggcgaa
     2221 cccgaccgtc ccgccgccca ccggccggcc ctcggccgga atcaccgctg accggcgctg
     2281 acccgcgctg accgactgac gaccgactga cgccgggcgg acggcgggct gacaacgggc
     2341 ggacgccggg cggtgaccgg aggaagcctc gggaagtccg ggagaagcgc gggagcggcg
     2401 tgagaggcta cctccaacgg ctccgcaccg tgcggcggac ggagccctcc ggccgccgac
     2461 agatcgggat ccgcccccat gaccgctccc agcgaccccg ccccctcggg cgtcccctcc
     2521 gccgccgttc cgccaccggg cggctccgcc ccgagcgccg ggggccgtct gctggcggtg
     2581 agcgacctgc acgccgcggt caccgacaac cggcccctcg tggagtcgct gcggcccacc
     2641 tccgccgagg actggctcat cgtcgcgggc gacgtcgcgg agcgccccga cgacatccgc
     2701 tgggcgctcg gcctcctcgc cgaacgcttc gcccgcgtca tctggacgcc cggcaaccac
     2761 gagctgtgga ccctggacaa ggacccggtc cggctgcgcg gccaggcacg gtacgcccac
     2821 ctcgtcgagt tgtgccggga cctcggcgtg acgacgcccg aggatccctt cccggtgtgg
     2881 accgggcccg gcggaccggt ggccgtggcg ccgctcttcc tcctgtacga ctacaccttc
     2941 cgcgcccccg gcacgcacac gaaggaggag tcgctcgccg ccgcgcacgg gacgggcatc
     3001 gtctgcaacg acgaatacct cctccacccc gacccctacc cgggacgcga cgactggtgc
     3061 cgggcccggg tcgcggagac cgaacgccgg ctcgcggggc acgaccccgg cctgccgctc
     3121 gtcctcgtcg gccactggcc gctcgtgcgc gaacccacgt cggtgctgtg gtacccggag
     3181 ttcgcccagt ggtgcggcac cgaactgacc gccgactggc accgccggtt caacgtcgcg
     3241 gcggtcgtct acgggcacct gcacatcccc cgtacgacct ggtacgacgg cgtgcgcttc
     3301 gaggaggtct ccatcggcta cccgagggag tggcgcgaac gcgggcatcc gcgcggtctg
     3361 ctgcgccaga tcctcccgta cgacgaggat ccgggccgca ccgccggcgg accgtccgcc
     3421 gagcgctttg ccgagggagg tccgtcgtga tcgagcggct gctgcccggg tacgtctcct
     3481 gcgcgtccac ccgcgccgtg agcgtgccgg accacaccct cttcccggag gaggaggcac
     3541 tgatcgccag gagcgtggcc aagcggcgca acgatttcgc gaccgtacgc gcctgcgccc
     3601 gccgcgccat ggccggactc ggcctggagc cggtcgcggt gctccacggg acgcgcggca
     3661 tgccgctgtg gcccgagggg ttcgtcggca gcctcacgca ctgcgaggga taccgggcgg
     3721 cggcgctggc acacggaacg gacgtgctct cgctcggcat cgacgcggag ccgcacgctc
     3781 cgctgccctc cggcgtgcac gagttggtga cgctgccctc ggaacgcgaa cggctcgccg
     3841 ggtgggagcc ggacggggtg cacggcatcc acggggaccg gttgctgttc agcgccaagg
     3901 agagcgtctt caagacctgg tatccggtga cccggatcga actcgacttc cacgaggccg
     3961 atctcacctt ccaccggccc gaacccggcg cttccgaggg caccttcacc gcccgcctcc
     4021 tgcgtaccga cccggccctg ccgtcgaccc tggagggccg ctggctggtc gaggagggca
     4081 tcgtcgccac ggccgtactg gtcacgcctt cctggcgcgg atcgggcggt cccgcgctcc
     4141 cgtgaccggg cggcggggac accgccgtcc gtccggagca catggagcac ggagcgcacg
     4201 gagcgcacgg agcacacgga gtgcgtctga ggtggccgcg ggcccggtcg ccgggcggcc
     4261 tcaggtgtcc tgcgggaccg tcaggggccg gccgagccgg acgttccagc gctcccgccg
     4321 tccgctcagt tccgtcagca ccagcgggcc gacgtccagc cgccagaaga cctccaccgg
     4381 cagccggaga gcgtggacga ccgcggaccg cacgatcgcg ggctccacca cggccaccac
     4441 gctcctgtcc cgtgccgtcg gcggcccgtt cgccgcgccc gacgggccgt ccgcgcccgg
     4501 cccgtcgtcc ccgctcggcc ggtggcggcc gtcgccgccc ggccggtcgc cgtccaacgc
     4561 ctccagccag ccgcccaccc gctccaccag agcgcgcagc gtctcgcccc cgtgcggagc
     4621 ggccgaggga tcgccgagcc aggccgccac ccccgccggc tcggccgcgc ccaccgcgtc
     4681 caggcgcagc ccgctccagc gccccaggtt ccagccggcg agcgcctgct cggggcgggc
     4741 ggcaagaccg agcgcggtcg cggtcccgag gcaccgctcg gaggggccgc acagcgcgcg
     4801 cgaggctacc ggcacggcgt cggccgcagc ccgcgcctgc cgctcaccgg accggtccag
     4861 cggcgcgtca ccgtcgaacc gggcctcgcg cagcgccgcg ttcatggccg gtgagatcaa
     4921 catcacccgt actgtcatgt tcctgccctc aagccgccga tcgtggccca acgcccccgt
     4981 atccagggcg atccgagctc cggggctccg cagattgcac catggcggca ccttcgccca
     5041 ggcggtaggg tcgcgtcgac catgacgagg gtgggacgga agccggtggg aatccggcac
     5101 ggtcgcgcca ctgtgtaccc gcgcccccgg tgcgggaagt cagacccggc accttcgtcc
     5161 gaggcaccac gacagggacg cgtgttccca caggaggttc tgccatggca cagtctgccg
     5221 ctcccacaac cggagcaccc gcgttcactc ccatctcggc gaaggccatc gccccctggg
     5281 cggtcttctt cggcatcctc atgctggtcc tgctgtactt cgtcggcgcg gagcagggcg
     5341 ccaccgcgct catctcgggc gaaggcgtgc acgaatgggt ccacgacggc cgacacctgc
     5401 tcggtttccc ctgccactga gccgcccccg gaatcaccgg cacacaaggg aaacaaggga
     5461 aagtctcgtg aactccatat ctgtcagagc tctgctcgtg cgcggcatgc tggcgggcct
     5521 gatcgcgggc gccctcgcgc tcgtcgtcgc ctacttcctc ggcgaggccc aggtggacgc
     5581 ggccatcgcg ctcgaagagg ccaacagcca cgaccacggc ggcggtgagg aactggtcag
     5641 ccggaccatg caggcgaccg gcggactggc caccggcgtc ctggtcttcg gcgtcgcggc
     5701 gggcggcatc gccgctctcg tcttctgcta cgccctcggc cgcctcggga ccttcgggcc
     5761 gcgcgccacc gccgcactgg tcgccggtgc ggccctgctc acggtctacg tcgtaccgtt
     5821 cctgaagtac ccggcgaacc ctccggccgt cggcaacccc gacacgatcg ggcagcgcac
     5881 cgccctgttc ttcctgatgg tcgctctcag cgtgctgctg ggcgtcgcgg ccgtcatcat
     5941 cggcaaacgg ctcgcgcccc ggctgggcaa ctgggacgcc accatcgccg cgtccgccgg
     6001 attcgtcctg gcggtcggcc tcgcctacgc cttcctgcct tcgttcgacg aggtcggcaa
     6061 ggacttcccg gcctcgctgc tgtgggagtt caggctctcg accctggcgg tgcagacgac
     6121 gctctggagc gtcttcggcc tcgtcttcgg ctacctcacc gaacggctgc tggttccggg
     6181 gaacggcccc gccgtgcccc gcgcggcgag cacggtgggc tgacggagca cggtccacga
     6241 cgcggaaccc gccgggactc cggcgggttc cggcgtgccc gggggtgcgc gcctcgggtc
     6301 ctgacgccgg gcgggccgcc cggcacccgt acggcgcgag cccggccccg gcaccgggag
     6361 atccggccgc cggggctgtg tcagccccgg ccggcctcgt cgactccgct cactgccggt
     6421 ccgccccgga accgaagtcg cccgtgagcg cggcggcgat ccgaaggtgg gacgccgcct
     6481 ccgcgccgcg tccctggcgc tccagcgtcc ggcccagcat gagccgggcg taactctcca
     6541 ccgggtcgat gtccaggacg gcccgcagtt cctcctcggc cctgcccagc cgcgccgagt
     6601 ggtagtaaga gcgggccagc agcagccgcg gagcgacctg ctccggagcc tcctcgacca
     6661 ggccgcccag gatgcgggcg gcggtcaggt actccttggc ctcgaagaac atctgcgccc
     6721 ggtcccaccg gtcggccgcc gtgccgaact cgtagtaggt gtcgttcacg tgtcctcctt
     6781 cgtgtggtgc cgaccgctgc cggcccgccc cgccgtacgt tcagccctga caacaccgca
     6841 tactcgttga acattccact aaaattttcg cgtgggcgca ggggtgttcc acgcccgcac
     6901 ccgaataggt tgagcgccat gagcaatctc gatcgccagg ccactccctc ggtctgcggc
     6961 gggcgcggct tcgtcgtcgc cgaacccgtc cgtgaacttc tcagcccccg ccacgtcccg
     7021 ctcggcgaag gcaccgaggt gcgccggctg ctgcccaacc tcggccgccg catggtcggg
     7081 gcctgggcct tcgtcgacca ctacggcccg gacgacatcg ccgacgagcc cggcatgcag
     7141 gttccgccgc acccgcacat gggcctccag accgtcagct ggctccatga cggggaagtg
     7201 ctgcaccgcg acagcctggg cagcttgcag acggtacgcc cccgtgaact gggcctcatg
     7261 acctcgggcc gcgccatcag ccactcggag gagagcccga agccccatgc ccgcctgctg
     7321 cacggcgcgc agctctgggt ggcgctcccg gacgagcacc gcaacgtcga gccgcacttc
     7381 cagcaccacg cggaccttcc gacggtgacc gcgccgggag tcggcgccac ggtcatcctc
     7441 ggcgagctgg acggcgctgt ctcgcccggc accgcctaca cgccgatcgt cggcgccgac
     7501 ctggcgctcg cccggggcgc ggaggcccgc ctgccgctgg agccggactt cgagtacgcg
     7561 gtgctgtcga tgtccggaga ggcggaggtc gacggcgtcc gggtgctgcc cggctcgatg
     7621 ctctacctcg gctgcggccg gaccgaactg ccgctgcgcg ccgcctccga cgcgggcctg
     7681 atgctcctgg gcggcgagcc gttcgccgag gagatcgtca tgttctggaa ctggatcgga
     7741 cggtcccagg aggaggtcgc gcaggcccgc cacgactgga tgaacggcac ccgtttcggt
     7801 gaggtgaagg gctacgacgg cccctcgatc ccggcccccg agctgcctgc ggtaccgctg
     7861 aaggcgcggg ggagggtgcg ctgagccggg attgtcgccc ggactgacct caggcccagc
     7921 cgcgccccga ccgatgaacc gcgtcacgtg agcagcggct ccgcgacagc ggggccgggt
     7981 gttcgcggcc cgcgtcacgc gaacttcgcg acggccgcct tccccggccg gtccgggccc
     8041 gccggcgatc tgatccgggc gtgtacgagg agcgcgtttc ggcggccggt tctgtgcggt
     8101 gccgctcgcg ctcccgtctc cagcttcgta cgcgggcgga cgttgtgcgg cgggcgtgcg
     8161 aggcggggtc cccacgcccg gggcgtaggc atcgggcaca tgctcgcgtc aagtgcggtc
     8221 tcgcgctctc ttcccgcggc gggtggggct gcccgatcct gcggagggat gcaacgcatg
     8281 ctccggtgct ggtccggctg gtcgcggggt cggtgccgca agtgaggctg gtgccgtatg
     8341 gccgctgtcg tccctcctcc ctccactgcc atgccgatgc cggaatcgat cgacggtccg
     8401 gccgcgcttc gctctctccc gccggccctg ctgcccgcgc cggcggctga gatccggtcc
     8461 ttcctcgtgg aaaaggtgtc ggcgaccggg ggacatctgg ggccgaatct gggcgtggtg
     8521 gagctcacga tggctctgca ccgggtcttc gacgtcgagg agggcgacgt cctgctcttc
     8581 gacaccgggc accagacgta tgtgcacaag ctgctgaccg ggcgccgggc cggatccgac
     8641 gggctgcgcc aggagggcgg gctgtccggc tatcccggtc gcggggagtc ggcgcacgac
     8701 tggatcgaga attcgcacgc cgcccagggc gttcgtcccg cacggcgaac gcggcccctc
     8761 ctggcccggg ccggactgtc cgcctcgcag atcgcctcca cggtcctgcg cgcccgtgcc
     8821 ggcaaaccca gcctgcccga ctgcctcttc gacgggagcg cggtatgacc gcggtcgacc
     8881 tgccccagcc caccgtcccc tcgcccgccc acaccccggc ccgccgccgc cgaacccgcc
     8941 aggtgcgggt cggcgacgtc ctcgtcggcg gtgacgcacc ggtcaccgtc cagtccatga
     9001 ccaccacccc caccgccgac gtcgacgcca ccttgcagca gatcgcccga ctcaccgccg
     9061 caggctgcga catcgtccgg gtcgccgtgc cctcccagga cgacgccgac gccctccacc
     9121 ggatcgccgc gaagtcgaag ctcccggtga tcgccgacat ccacttccag cccaagtacg
     9181 tcttccaggc gatcgacgcc ggctgcgcgg cggtccgcgt gaaccccggc aacatccgga
     9241 agttcgacga caaggtccgc gagatcgccg aggcggccac ggcggcgggg atcccgatcc
     9301 gcatcggcgt caatgccggc tctctcgacg aacgggtgct gaacaggcac ggtgcggcca
     9361 ccccgcaggc ccttgccgag tcggcgctgt gggagtgcgc gctgttcgag gagcacggct
     9421 tcaccgacct caagatcagc gtgaaacacc acgaccccct gacgacgatc gccgcctacc
     9481 ggcacctcgc ggcccggtgc gactaccccc tccacctggg agtgacggag gccgggccgc
     9541 cgccgcaggg caccatcaag tccgccaccg ccttcgcgat cctcctgaac gagggagtcg
     9601 gcgacaccat ccgcgtctcc ctgaccgcgc cgcccgtcga ggaggtcaag gccggcatcc
     9661 agatcctgca ggccctcggc ctgcgccccc gccagctgga aatcgtctcc tgtccctcct
     9721 gcggccgggc ccaggtcgac gtctaccggc tcaccgccaa ggtccaggcc gccttcgaag
     9781 gcttccccca ccccctgcgc gtcgccgtca tgggctgcgt cgtcaacggt cccggcgagg
     9841 cccgcgaagc cgacctcggc gtctcctgcg gcaacggcaa gggccagatc ttcatccgcg
     9901 gccgagtcgt cagaaccgta ccggaatcac agatcgtcga ggcactcctc gaagaagccc
     9961 tcaacgtcac cgaaacggcc tccgccccgg gcggcgccca gtgaccgccc tcgccgcgtc
    10021 ccccgccgcc ccgctggacc cggacgacat gcgtaggacc gtcgacgccg tgctgtacgc
    10081 cttcctcgac gaacaggaac aagcggcccc cgatctcccc gagatcgccc tgttcaccgg
    10141 aatgctccgc accatgctcg ccgccggcgg caaacgcgtc cgccccttcc tgtgcctcac
    10201 cggctgggcg gcgatcaccg accagccacc gccgcccgcg gtatggcgga tggccgcgtc
    10261 cctggagctg ttccacgcct tcgccctcat ccacgacgac atcatggaca ggtccgacac
    10321 ccgtcgcggt cgccccaccg cccaccgcgc cctggcctca caccacgccc accgcgcgga
    10381 cgccgacgcc ctgggggtga acaccgcgat cctgctgggc gacctcgccc tgggctggtc
    10441 ctacgaactc ctgcacgtca aggacgcccg gctccgacgg acatggggac cgctgaacgc
    10501 gctgcgcacc gaaaccctga tcggccagta cctggacctg accgcgacgg gagatccgac
    10561 ggccgaagcg gacacggcgt ggcgcatcat ccgctacaag acggccaagt acaccatcga
    10621 gcgtcctctg tgcctgggcg cggtcacggc cggcgcggac cccgcccgac tacggtccct
    10681 gtccgcctac gcgatcccgc tcggtgaggc gttccagctg cgcgacgatc tcctcggcgt
    10741 ctacggggac cccgcccgga ccggcaagtc gaccctggac gacctgcgcg agggcaagca
    10801 caccgtgctg gtcgccaccg ctctcgaccg ggcgacccct gcgcagcgcc gcaccctcac
    10861 cagtctcctg ggcgaccctt ccctcgacca ggagacggcg gacgtgctgc gagcggtact
    10921 gaccgccacg ggggcggcag ccgccgtgga acagatgatc accgaccggt tccacgcagc
    10981 cgaacgagcc ctggacggga gcgccctgcg gacccacgcc accacagcac tgcgccgcct
    11041 cgccgcctcc acggccaccc gcgcatcctg acggaggggc catccggacg agacagctca
    11101 gccccccgcc cagccgctcg ggtgaacccg cgagcccact cggcgacctc gcccccgacc
    11161 tgcctcgcgg acccccgtac cacctgaccg tcgcaccggg ccgagcaact gccgaccgcg
    11221 ccgcgccggg ccgacggcca gtcccgagta acaccgccgc cgccccctac cgggggagtc
    11281 atacggactg ctggggcccg accccgagta acaccacacc acgagggagc ccgccatgcc
    11341 cgagatcccg gacacgacca cctcgcaact gctccacgtg ccgccgctgt actgccccat
    11401 cggcgcggcc gttcacccgg agctcgacag catcaaccgc gattcccgga tctatctcga
    11461 ccgctaccac ctccacacca gcgatatcga ccgggcctgg gtcatcgcgc ggaactacgc
    11521 ggaggcgatg gcccgcatct atcccgaagg catcaccgac cgcgtcgcgc tcaccgcccg
    11581 atggctgcac tggatcttct acgtcgacga cgtccgcatg gaaaccgcca ccacccccga
    11641 caagctcgcc tcggcgatcg gcctcaccag ccacctgctc cgcgtcatgg agtccccggc
    11701 caccgagccg acggcggatc agaccggccc ggtcgccgcg ctccagtcac tcatgacctc
    11761 ggtgcaggcc gtcgccaccc cgacccagct ccaccggttc gtcgacgccc accgcaagtg
    11821 gttccacgcc atcctgtggg ggatggccgc ccccgccctc tccagcctgg acgagttcgt
    11881 gcaccagcgg atgctgaacg cgggcggcgc cgccagcctg tgctggtcgg agatcaccac
    11941 cggggaggag atccccggcg acgaattcca ctctcccgcc atgcgcgccc ttcaggagtc
    12001 gtccttcctg atgatggccc tcgacaacga cctgctctcc tacaaccgcg aacgcctcat
    12061 cgacggtacg aaactcaaca tcgtgatgct gctcgcccgg ctgaacgact gcccgcccga
    12121 gcaggccatc caccaggccg tcgccctgcg ggaccgcctg acgacactgt tcctgcgcct
    12181 gcgcgagcag gaacacccca agctcagcgc cccgggaagg gcctacgtcg cggacctcgg
    12241 gtacgccatc cgctccaacc tcgactgggg ctcgcactcc gcccgctaca ccgttgtggc
    12301 ccctcgcacc cagctcccac cggagaaccc cgcccccatc ccgctgaccc tcaccgacca
    12361 tcccggcgac cccagcacgg aacccctgcc ctgcccctcg atcgcctggt ggtggcaaca
    12421 actgcgcacg tgagaacacg gctggtccac gacgaacgtc cagccgtggc gggcccgccc
    12481 cgcggtgcgg gtccggttcc gggatcacct gtcccgagaa gggccgctca gcctcgtgcg
    12541 ggccgcacgt cgtccacggc ggcccggacg cgccaggagc ggacgcagca ggacggcggg
    12601 ggaggcgacc atgttctgca cccgcgcgaa gcgcgcgtac aactcgggct cgtccggcag
    12661 gcgcctgagt accacgtcga ggaagccccg tatcatccgg gccgggcggc ccgtgggctc
    12721 gctggaccag ccgccgtcgg cggccgtggc cgtcagccag ggcaccagcg cgatccgggc
    12781 ggcacggcgc tggaagcggt gtgcgagccc gctcgggccg tccgcggtcg ccagcaggcg
    12841 ggccagcagc cgagcctgga gcgccgccac cgtgagcccc tgcccgtaca cggggttgaa
    12901 ggcgcagaac gcgtcgccca ccacgagcag ccggtccgga caccctcgga ggcggtcgta
    12961 acggagccag tggttaccgc ccaccacgca gcggtacacc ggggagaccg ggcggccccg
    13021 tgccatcacc tcggcgaagt gcgggctgcg cagcgtcgcg gcgaaccgtt gcagtgcctc
    13081 gtcgtcacgc ggcggcggga gctcctccgc cggggcgacg aggctgatca gccgccgcgt
    13141 gccgtccacc gtgatcgccg cgccgccgcg gtccaccgag ggcggcaggg tcatctcgaa
    13201 ggccaccagc cagtcggggg cctggccgtc ggtcagctcg tacatgcgcg agctgtagac
    13261 gagtggggag ggcacctcca accgccgggg ggcgggcagc ccggctgcgg cgagccagcc
    13321 gggcagccgc gacctgcggc cggccgcgtc cacgaccagg tccgcttcga tccgtaccgg
    13381 cttgtggccg gggtcggccc ggtggtggcc cgtgacgccg accgtccggc ggcggtccgc
    13441 gctgaggtgc agcccctcca cgacgaatcc gtcccgtacc cgaacgcccg gcagcgcacg
    13501 gaccctggcc cgcaacaccg cctccaggtc ggtcaggtcg aaggactgca cctcgatgcc
    13561 gaccgagcgc cggggagccc agccgtacgg caggcgggtg gcgaagcccg ccccgaagtc
    13621 gaagaccggg gccccctgag cggccagctc cgcgcggact ccgggaaaga ggtcctccac
    13681 gatcagggcg ccgcgtgcca gcagcccgtg cgggtgccgc gcctggggca gtccgctgcg
    13741 atgtgcgggg ccggaaggga gttcgtcccg ctccagcacc gtgacgcggt cgaaacgtcc
    13801 agcgagcacc cgggcggtga gcagcccggt gaagcccgcg ccgatcacca cggcatggcc
    13861 ccaggacccg tgcgagacct ccggcgggcg ctgcctgtcc gccgcgtgct ccgcacgccc
    13921 gtgaccggct cgctccttca cgggctctcc gccggcgtcc ctcaccaggc gaccggcagc
    13981 tgccaggggc cccgcatgat gccgtccttc cagtccagct cctccaccgg tacggcgggc
    14041 cgcagcgcgg ggaagcgccg gaccagtgcc agcagggcga tggagagttc cagacgggcg
    14101 agctgcccgc cggggcagta gtgcggcccg gcgccgaacg ccaggtgctt tccggcgtcc
    14161 ggacgccgta tgtcgaggcg atcgggttcg gagaagaccg ccgggtcgcg gttggcgacg
    14221 cagttgaggg cgttcaccgc cgtccccggg ggcagggtga ccccgagcag gtccacctcc
    14281 gccgtggtga cgcgcatcaa catgccgacg cggctgagga gctggtggcg caggagttcg
    14341 tcgacggcgc gcggcaccag ttccgggctc cgcaccagga ggtcccactg ctcgcggtgg
    14401 gcgaacagcg ctaccaggga attggagagc tggttgtgcg tggtgtcgtg tccggccacc
    14461 agcacaggta tcaggttcgc cagcaccgtg gcgtcgtcca gcgggaggcc gtccggccca
    14521 ggggccagca gcgtgctgat caggtcgtcg ccgggggcgc gccgcttcgc gccgatcagc
    14581 tcttggaggt acgtggtgag ctgctccgcc gccgtggccg cctctccggc ggagcccgcg
    14641 gaggcgggca ggatcgcttc gatccactcc cgaaaggcgt cgtggtcctc gtaggggacg
    14701 ccgagcagcc ggcagagcac cttgacgggc agtggcgcgg tcagatgggc gaccacgtcg
    14761 gcgggcggtc cggcggcctc catcgcgtcg agcatctccg ccacgagcgc ctcgatctcg
    14821 gggcgtagac gctcgaccgt gcgcgcggtg aaggcccggc cgatgtgcgc ccgcagggcg
    14881 gtgtgctccg gcgggtccat ggcgtgcagc agcccgttct gcgcgtggaa ggggacgacg
    14941 gacggcaccc ccgggcggga tgcctcggcg cggctgaagc gcgggtcgat cagcacctgg
    15001 cggacggcct catggctgag cgcgaggtgg atcggggcgc cgtcggccat gaccgccgcg
    15061 gccacaggcc cctcgcccaa cagcgccgct ccgctgatgt cgtggtcggc ggaggggtcc
    15121 tgaggggacg ggaagacagg gcatccgtcg ctggtgggca tggcgcggga ctctccaggg
    15181 ggcacatcgc agggggcctg ttgctcctgc ggaacacgca gtgtgaatac gggcgacggg
    15241 cggggcaaga gggcgttcca cccagtggaa cagcggcttt tcgctcacag gttcggtccg
    15301 cagactctgc ccgcccagca ccgtcacctc ccggagcgca caccatgtct gaacctctgc
    15361 tcgtacccga cctgtactgc ccgttccccc gtgccgcccg tccccatgcg gacacggtcg
    15421 agcgggaggt cgtggcgtgg atggagcgct tcgaactcat tcggacaccg gcggagcggg
    15481 agcggctctc cggtatcagg atcggctggc tgacaggtgc cgcacacgcc gacggcctgc
    15541 tcgaaccgag catcatcgct gcgcagttga ccgcctggct gacggccttc gacgaccggt
    15601 acgccgactg cccccgcccc gacgaacagg gggtgcccac cgcccgtctc gtactgcggc
    15661 tgcgagccgt gatggaggac cccgccgccg ctcccgcgcc cgacgagccg tactgcgccg
    15721 gcttgcgcga cctcttccta cggctcgccg cgtgggccgg ccccgagcag ttgatgcggg
    15781 tgcgcagcag tatgacggag tacttcatgt cggcgctgtg ccaggtgaca tacggcctcg
    15841 gcgcttacac gccgacgttc gacgagtacg tggagctgcg gcgctacacg gggatatgcc
    15901 acatcgtgtt caccctcgtg gacgtggctc gtgggttcga actgcccgga gcggtgtggg
    15961 cgggcccgga ggtccgcgcc ctcaacaccg ccgcggcgga cgtcatcgac tacgccaacg
    16021 acgtactcgg ttcccgcaag gagttcacgc acgaggacga tctggcgcgc agcctgccac
    16081 aggtgctggc ccagcagtac ggatgcgacc acgcggaggc gctgcggagg gccgccgcga
    16141 tacacgacga ggcggtccgc gccttcatgg cgctcgcctc cgaggtgcgg ctcgcggcgg
    16201 atccgctgct cgcccggtac atagcgggcc tggagacctg gatggtggcg cacttcgact
    16261 ggtacggggt caccaaccgc tacgacagcc accgcgagca ggtgcgatgg gcgtagcggg
    16321 caggctgccg ctcggccgca cgtccttaga atcacttgcc agcccccacg gtccgacagg
    16381 agcaccatcg tgacgtatgc cctcgacgcg aggccgaggc aagcggcgga acaggcgccc
    16441 ggcgccgcgg agaaggccct cctgctgctg gagagcctca ccgcgttgtc ggccgcagga
    16501 gtaccgccca ccctcaccgg cctcgccacc gccagcggtc tggcgaagtc caccacgcac
    16561 aggctgctgt cactgctcgt caggcgcggg atggtcacct gcacggacgg cgcctaccgg
    16621 ccgggcccgg cgctggccgg cctggccgcg gcggctctcg ggctgcccgt ggaccgatta
    16681 cgctcgacac tcctgccgca catggtggac ctgtacgaac tcacccacga gaccgtcaac
    16741 ctggcggtgc tccaggggcc ggacatcgtc ctgatcgagc gcgtacacgg cagccgcacg
    16801 cagcgatcct ccgtccggct gcccgagcgg gtgccggcgc acagcaccgc actgggccgc
    16861 gcgctgctcg acgccgccgg tacgtccgcc accgccccgc cccacgccgg cgttcccggc
    16921 gatcgcaccg gcgtcctgct gtccgagatt cgccggcaag gcatgtcgac gagcctcggt
    16981 gaactgatcc ccggcgtcgc ttgtctggcg ctgcccatac tggacgaggc ccgcaatccc
    17041 gtcatggcgc tgtcggtgtc cggctgggcc cagagcatga accttctctc cacggcgaag
    17101 caccttcggt cggtgagtct ggcggccggc ctggcactgc tcaccgagga ggattgaacc
    17161 cgccggcggt cgcgccgccc tccggcccag gtctctgcgc gtgagccggg tgagtggtct
    17221 tggcggcagt gccgtgggag gacgggcgag ggcggggaga ggtaggggac cacatgtcct
    17281 cacccacgga gttctcgatg aagcgcactg ccacggtcgt cacctgtgtc gccgcgttcc
    17341 tgttcaccac cgccctgacc gggtgctcca gcggctccgg cgacgcttcc ggggaggggg
    17401 aggggcacgg ccccgtctcc tccagtgcct cgccctcgaa gccggccacc gtcgacacga
    17461 agtccgccgg caaactcggc accatcctcg tcgacgacaa gggccgcacc ctctacctct
    17521 tcctggccga caagaagaac aagtcgaact gttccggcgc gtgtgccaaa gcctggccgc
    17581 cgctgctcac gaagggcgac gcgaagcccg gaaagggcgt cgagaagaag ctcctcgaca
    17641 ccaccaagcg ctccggcggc ggcacacagg tcacctacaa cggccatccc ctctactact
    17701 acgtcggtga ctccaagccg ggccagacca acggccagga cctcgaccag ttcggcgcgg
    17761 agtggtacgt cctgaacgcc aagggcaagc aggtcggaag ctgagcaggg agagcggcgc
    17821 ggtcacgggg cgcggccggc accgccgagg cggcggccgt gccacgggcg ccgtgctcgc
    17881 ccttctcggc gtcctgctcc ccgtcgcggt cggcgtgggg atctacttct tcggcaccca
    17941 ccacaccccg gactacgaca gcgggctcta cggggagcac ggggccgccg cggtcgacct
    18001 caaggcgcgc ctgggcagcg ccctcctgtg cctggccctc atccaactgg ttctcgcact
    18061 gtggatgtac ggacgcgtgc ccggagcccg ctccgcgccc cggtccgtcc ggttggggca
    18121 ccgggtgctg gggttcctca ccttcctctt ctcgctgccg atcgcgtacc actgcctgga
    18181 gacctacggg atcgagacga cgtccccccg aacggcgatc cactccttcg ccggatgcgc
    18241 cctctacggc gcgttcgtgg cgaaggtgat cgtcgtgcgc agccggcgcc tgcccggctg
    18301 gatgcttccg gtgatgggct cgctcctcgt gctcggagtg gcccttctct ggtacaccgc
    18361 ggctctgtgg gttctcaacg gagactcggt tccgggcttc tccgagtcct gagcgaggag
    18421 acacctccac gcccccgtgt cacagcgggc aggtgcggcc gtcgacgcgg gcgtccgaca
    18481 cccaggcggc cggcgcgtac gcgtcgtcgt acgcgaagtc caccaccacg ccgacgctga
    18541 gcgtcccccg ggaagggacc gttcggttgt agtcggccgc ggtcacggtg accaggtcgc
    18601 ccgtggtcgt ggccgtgccg ttccagacct ggacccgcgc tttgtccggc acgcggaacg
    18661 tcagtttcca gcccgcctcc agggccgtgt ccgacgtgat gttcaggtcg gcctcgatgc
    18721 cctcgttcca ctggttgcgg atccggacgt ccgctgaaca cgcctgcgac ggcggccggc
    18781 tcggcttgtc ctcgtcctct tccggagtcc ggtcggaggg cgaggggctg accgtctcgc
    18841 ggtcctcggc gggtgcggag gccgaagggt cggccgtcgc cgaccggtcg gggccgccgg
    18901 gctttcggga cacctccggg gcatcgtcgg gcgcaccgct cccgggaagt tcgcgttgca
    18961 cgcccggtcg aaggagtgac gacgcaggtc gcgcgtcctg ctgggaggca tcgtgcagaa
    19021 cgagcatccc gcctcccagg agcaccagcc cggttccgat cccggccgcc ttcatcagcc
    19081 ggctcctgcc ggcgctgctg ccggtggtac ggccttcggt cccgccgggg agcacccgcc
    19141 gccccgcagg ccggaccgaa cgcgacgggc gaacctccgc gccgttcggc tgttgcgaca
    19201 actgccggcg gcgccgggcc acgtaggcgg ggccgctcca cttgagcgtc gcctcggcga
    19261 cgagtccggg cagtacgtcg tccgccctgc tcaggcactc gaaagccgtg ccgcagacga
    19321 ggcatccgtt caagtgctcc agaagatcgg gcggtgtcgt gggagcgctc ccgcgcgcgg
    19381 cggcgtccaa caggctcgca tacgaccggc agacgggatc ctgcacctgc gcacggtgta
    19441 tcagcgagct ccgttcccgg aaggactccg tcacacggac caggtccgcc gccgtctcgg
    19501 ctcgcggccg gtccagccgc tcggcgacga ccgtgtccgg caacccttcg acgcagctcc
    19561 accacagcag ttcgctgtcg tccggatcca tggcgcacag ggcgcgcagt gccagtgacg
    19621 tctcggccga cgcccaggga tcccatggct cggcaccggg atccgccgcg tgttccgtga
    19681 gccggttcag caggtccggt gcgaggaccc gggcctcttc gggcgaggac gacatctcca
    19741 tggccacgat gagcacggtg ttgagtgcgg cggggacggt gggcagttcc tccgcccagg
    19801 aaggctccaa ctggcgtgag gcgcgcgtcc gttcgcctgc ccgtgcggcg agcgcctcgg
    19861 cggcggtgga cgtacgcgtg cacagccggg cgtacgtgtc gacggggtcg gactcgtcgt
    19921 cccacaggcg gcggccgatg aacggcgtcg cgggcgcgga ggcgtcgagg gagcggctgg
    19981 ttgccggagg ggggacgagc gactttgaca cgagtcctct tccatggaag tgggggagcg
    20041 cgacagccgc ctgcgcggtg gccgaggaag tcactgcggg ccacgtccgc cgagacactg
    20101 ggcgcggtca tgcgatgccg aggctgtcat ggccgcactg ccgagacaag atccatccga
    20161 agccgggtac ggggcacggc cgcggctcgt acgacggtga cccggcgggg gcgcggtggc
    20221 cggaacaccg cgcgccggtc atctccgacc ggccctcgtc ggggcccgac cgccatcgcg
    20281 cccgaccggc gcacccgtcc gcgccggtcg ggcgcacgga tcgccgcacc ctgcgagcca
    20341 cccgcgtccg cactggtgag cgccgctccc ggtcttcgag ccccgcgacg cggtgcggcc
    20401 cgaacgggtc ctggcgacct cgccgcacgt ccgacggccg acggcgatcg gcccgtcccg
    20461 tacctcgccc gagcccggcc gtcgcccgac cggacgcgta cggccgagag ccgggggcgc
    20521 ggaaggacgc cttgccgagg gcgtgaaagc ggcaggccgt cggagggcaa tactcatggc
    20581 cgctgaacgg ttgcaccgaa ccggccgagt gccgcgggcc tcctgccggc ctcatcgctc
    20641 atacctcatg agcaatgggc gggcccggcc cttgatcccc ggccctcgac ccccggccct
    20701 cagccccgcc ggacctcggc cgccggccac cgtcgtggcc agcggccgag gtccggacgt
    20761 cgccgacgtc agggacgtga tcagccggcg gaccagatcg acacgttgtc gatgttgagc
    20821 cacttgcccg ccgggctgtc cgaccagatg ccgaggttca ccttgcccga cgacacggtg
    20881 aaggtcagct tcttcgtcgc ccaggtgtcc tgcttggcgg tgaggtgcac gggcaccgcc
    20941 gacccgccgt gtcccttcac ctcgacgtag gcgctcttct ggccgccgct ggaccggtag
    21001 tcgaaggaca gctcgtagga gccgttgggc agggcgacct cctggctgat ccaggaggtg
    21061 tacgccgcgt cgtcccacac cgcgagctgc cggcggccgt cgccgagcgt ggactcctcc
    21121 accttcccgg ggcccgtcac cttccactgc gggacccggg tgccggcgat gtcctggtcg
    21181 aaccggccgt tggcgacccg gttgcccgtg atcgtgcccg ccgccgcgtc gacgtcgacg
    21241 tcggtgtagc cgtgcaggac ggggccggag ccctcgaagg tgagcggata ccaggcgttg
    21301 cgtcctatgc ccccgggcgc gggcgagccg cccggcttgt agaactgcga gtaccggtcg
    21361 ccgttgtaga ggtaggacgt gcccttcgag ccgaccaccg ggatgatctg ctcgaactgc
    21421 gtgccgaagg agttgtccga ggagggccgc gtcgcgacgg tgctccacgg cgcggccttg
    21481 tcccagccgc cgagggtgct gctcgcgcgg tacgacgtgg cggtggcgtc ccagtagtcc
    21541 atgccggagg cgaacaggta gtaggtcccg ttgtccttca cgatggccgg ggcttccttg
    21601 tgggcgtacg actcggagta gaccgcgggg ccgaccccgg tccagtcgcc ggtgagcggg
    21661 gcgacgttga gcgtgacgtt gaagctcttg gcgtcgcccc ggcccgtgtc tccgacgtag
    21721 acgaggtaag ccttgtcccc gtcgacgaag accgagtggt caccggtggt gttgccgttg
    21781 atctccttgg ccgggcccgt cggcgtgtag gtgccgtcga tcgtcgggct ggtggcgaag
    21841 aggatctggt tgcggttccg gtcgccgtcg ttgacctcga cgaccaggac gaacttcccg
    21901 tccggattcc ggatgagctg gggacgtccg agccacaggc cctccgccag ggggccctcc
    21961 gagccggact ggctcaggac ggggccctcg tacgtccagt tctccaggtc ggtggagctg
    22021 tacaggttga tcgtcttcgg ctggccgctg accagcttct ggcccaccca gtagtagatc
    22081 gatccgacct tgaggacgtt gccgccctgg gcgaggatct cgttcccgtc ggtgtcggtc
    22141 caggcggtgt cgttggcgat gaccgacgag ggtcccgcgg cgtgggcggg cagggcgagg
    22201 ccgccggtga aggccagtgc cacggcggcg gtcagggtgg tgaggcgggt ggctcgcgct
    22261 cggaggttca tggggctcct cggacgatga cggctctgat ggtgaaaaaa aattatcacg
    22321 caagctaccc aagagaccca tgcgtgaaat aaatttgaac agccggtagg ccgtcgccct
    22381 tcctcgggcg cccccatcgc accggcacat cccacagcag cactggagta cctatgaagc
    22441 agaggtcggc ttcaccgccg ccagtcacgc cggtcgtcct ccggcggcgg ccgttgcggc
    22501 agcggttgac cgggtgggcc ttcgtcctgc ccttcgcagt accgttcctc ctggctgtcg
    22561 tggccccgat cgtctacacc gcgggcctca gtctcttcca ggaacgcctc atcggcggcg
    22621 tgacgttcgt cggtcttgac aactacgggg agcagctgag cgacccacgg ttctgggacg
    22681 gggtcgcacg ggtcggcctc ttcctgctca tccaggtgcc gctcatgatg gggttcgcac
    22741 tcggtgcggc gctggccctg gacagcgcgc ggctgtacgc ccccgcgatc ttcaggctcg
    22801 gcatcttcct tccctacgcc gtgccgggcg tggtggcctc cctgctgtgg ggttacatct
    22861 acggggcgca gttcggtctg gtcggtgacc tcaaggagct cttcgacatc gccctgccgg
    22921 acccgttgtc gagcacgctc atcctgccgt cgatcagcaa catcggcctg tggctctacg
    22981 tcggctacaa catgctcgtc ctctacgcgg cgcttcagtc catcccctcg gagctgttcg
    23041 aagccgcccg gatcgacgga gcgggcacct ggcacatcat cgtcggcatc aagctgccgg
    23101 ccatccgcgc gaccctggtc ttcaccacga tcttctcggt gatcggcggg ttccagctct
    23161 tcaacgagcc caacatcctg cgagcgatgg tgcccaacgt gatcagcacc gacttcacgc
    23221 cgaacatgta cgcctacacg ctgtccttcg ccggacagca gtacaacagc gccgcggccg
    23281 tggccatgat catgggcgtg gtcaccgcgg tggtcgcctt caccgtgcag cggcgtggca
    23341 tgaagggggc cgtgtgatgc tcacccagga caagtcgccc gacgtcggcc ggaccgcggc
    23401 gccctcccag gaacgcgccg agccccggcg ggccgtcgtg cgtcgtcgcg agccgcgcga
    23461 gaaaccccgt cggcagcgct cggtcgccct gaccgtgctg atgacgctgc cgctgctcta
    23521 cagcctgttc ccgctggtct ggctcgtcat gaactccacc aagtcgctgg acgacctgtt
    23581 ctccagcttc ggactctggt tcggcgacga cttcgccctc tgggacaacg tggtcggcgt
    23641 cctcacctac gacgacggca tctacgggcg ctggttcgcg aacacgctgt tctacgtcgc
    23701 gctgggcgcg ggcggctcga ccctcctggc ggccctcgcc ggatacggcc tcgccaagtt
    23761 cgacttcccc ggccgccggg cggcactggc cgtggtgctg ggagccgttg ccgtaccggg
    23821 aaccgcgctg gccgttccca ccttcctgct cttcagccag atgggtctga cgaacactcc
    23881 gtggggcgtc ctgatcccgc tgctcgtcac gccgttcgga ctcttcctcc tcttcagcta
    23941 cgccaacgag gccgtgccga acgaggtgct ggacgccgca cgcgtcgacg gtgcgggcga
    24001 gttccgcatc ttcttcacca tcgtgatgcg gctgctgtcg ccggcgctcg tctccgtctt
    24061 cctgctggaa gtggtgggcg cctggaacaa ctacttcctg ccgctcatca tgctcagcga
    24121 cccctcgtgg ttcccgctga ccgtgggcct gaaccggtgg aacgcccagg gcgccagcgc
    24181 ggagggcgaa ctcatcgcca acctcgtcct caccgggtcc ctcatgacga tcgtcccgct
    24241 ggtcatcgtc ttcctcttcc ttcagcgctt ctggcgggcc gggctcgccg ccggcagcac
    24301 gaagggctga tgtctgccgg agcgctccgg cggcccgccg gatgtcctcc gagcgctgaa
    24361 cgtccgagcg ctgaacgtcc gagcgctgaa cgccccaacg gaacagctcg cggaccccac
    24421 gagaaaccaa ggaaaaggaa tcaacgtgaa cagatggtcg cgtcaccgca gaacgacctc
    24481 cctcctgctc ggctcggtgc tcaccgcggt gacggtgacg gcctgcggcg gcggcgccca
    24541 gggcggctcc gagcccgagt ccgtcagtga gaaggagatc cgggcggcac tggagaagcc
    24601 gaccgaactg accgtctggt cctggtccgg aagcctgccc gacgtcgccg aggcgttcga
    24661 gaagaagtac cccaaggtca agatcaaggt cgagaacgtc ggcaccgcgg ccgagcagta
    24721 caccaagctc cagaacgcga tcaaggccgg caagggcgcc cccgacctgg ccaccgtcga
    24781 gtacagcgcc attccccagt acgcgctctc gggcgcgctc gtcgacctca agcggttcgg
    24841 cttcgactcc ctgaaggacg agttcacccc ggccacgtgg gattccgtca acgtcgggga
    24901 cggcctgtac gaactgccgc tgaacgccgg tccgatggcg ctcttctaca acaagaagac
    24961 gttcgacaag ttcgacatcg cggtgccgac gacgtgggac gagtacctgg aggcgggcaa
    25021 gaagctccag aaggccgatc ccgagtactt catcagcgcg gacaacggca acgcgggcct
    25081 caccgagagc ctcatatggt ccgcgggcgg caggcccttc aaggcggacg gcgagaagat
    25141 caccgtcgac ctccaggacg ccgggtccaa gaagtacgcc gagagctacc agaagctgct
    25201 cgacgccaag gtcctctcag gagtggcggg ttggtcgaac gagtggttcc agggcctggc
    25261 cgacggcaag atcgccacgc tcacgtccgg ggcctggatg gcgggcatcc tcaagggcag
    25321 cgtcgccaag gcgtccggtg actggcgggt ggctccgatg ccctcgtacg acggcgagac
    25381 caccacatcc gtcaacggag gcggcagcct cgcgatgacg gagcagagcg acaagaagct
    25441 cgccgccgcc gcgttcctgc gctacgtcag cgccgaggag ggcgcggaca tcacccaggc
    25501 gaccggttcc ttccccgccc gcgccaaggc gctcgcggcg gagaagttcc tcggcgccga
    25561 ggacgagtac ttcggcggcc aggaagtcaa ccgcgtcttc gccgactccc tcgccgcggt
    25621 gggcgagggc tggcagtacc tgccctacga cgtctacgcc atcaccatct tcaacgacaa
    25681 ggtcggcaag gcgtacacgg gcgagaagac gctccaggac ggtctgaacg cctgggagca
    25741 ggaactgctc aagtacggga aggaccaggg attctccgtc aactgacacg cacgggagcg
    25801 gaacgggccg ccgtcccacg gcggccctcc tgctccccgc cgtcaccctg ccggccgaga
    25861 ccgaaccgcg acttccggga accaacagtg ccttacggcg tgactccgtc cgaaacgaac
    25921 cctccggagg accggtgcgg acagcccgcc cgtccggccg gtaccggcag cgccgcggcc
    25981 ggccgatcgt gggggagcgg ttcatgagcg gcgacgcgga gtcgagccgg cgcccttcct
    26041 ctttcggggc cgatgggtgg cggacagnnn nnnnnnnnnn nnnnnnnnnn nntgaagttc
    26101 gtggcgaagg cgagggagca cggtgcgctg accgccgtca tcaccggcag cccgcagtcc
    26161 cccatcgccg ccgaggtcga tgtggcgctg cacaccggca ccggggtcgg cggctcctgg
    26221 acggactact tcgccggacg ctccagcgac tccctgatcg gcgcgctgct gtgggccctg
    26281 gtcgcccagc ggatcccgga ccgcatctac ggccgt
//
