LOCUS NZ_ML123034 10798 bp DNA linear CON 23-MAY-2024 DEFINITION Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun sequence. ACCESSION NZ_ML123034 VERSION NZ_ML123034.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. ADI96-02 ORGANISM Streptomyces sp. ADI96-02 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Streptomyces spp. from the marine sponge Antho dichothoma: analyses of secondary metabolite biosynthesis gene clusters and some of their products JOURNAL Unpublished REFERENCE 2 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Direct Submission JOURNAL Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1, Bielefeld 33615, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.8 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 64.8x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_003846185.1-RS_2024_05_23 Annotation Date :: 05/23/2024 03:48:04 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,089 CDSs (total) :: 6,032 Genes (coding) :: 5,843 CDSs (with protein) :: 5,843 Genes (RNA) :: 57 tRNAs :: 54 ncRNAs :: 3 Pseudo Genes (total) :: 189 CDSs (without protein) :: 189 Pseudo Genes (ambiguous residues) :: 0 of 189 Pseudo Genes (frameshifted) :: 68 of 189 Pseudo Genes (incomplete) :: 155 of 189 Pseudo Genes (internal stop) :: 10 of 189 Pseudo Genes (multiple problems) :: 42 of 189 CRISPR Arrays :: 2 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 01:00:53 NOTE :: This is a single region extracted from a larger record! Orig. start :: 6266514 Orig. end :: 6277312 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to ML123034.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Zotchev Lab, Department of Pharmacognosy, University of Vienna. Annotated using prokka v1.11 from http://www.vicbioinformatics.com. FEATURES Location/Qualifiers region 1..10798 /candidate_cluster_numbers="1" /contig_edge="False" /product="RiPP-like" /region_number="25" /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /tool="antismash" cand_cluster 1..10798 /candidate_cluster_number="1" /contig_edge="False" /detection_rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /kind="single" /product="RiPP-like" /protoclusters="1" /tool="antismash" protocluster 1..10798 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[5000:5798](-)" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" /tool="antismash" proto_core complement(5001..5798) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))" /neighbourhood="5000" /product="RiPP-like" /protocluster_number="1" gene 269..694 /gene="panD" /locus_tag="EES43_RS27410" /old_locus_tag="EES43_27045" CDS 269..694 /EC_number="4.1.1.11" /GO_function="GO:0004068 - aspartate 1-decarboxylase activity [Evidence IEA]" /GO_process="GO:0015940 - pantothenate biosynthetic process [Evidence IEA]" /codon_start=1 /gene="panD" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_003964661.1" /locus_tag="EES43_RS27410" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27045" /product="aspartate 1-decarboxylase" /protein_id="WP_124271236.1" /transl_table=11 /translation="MLRTMFKSKIHRATVTQADLHYVGSVTIDGDLMEAADLLPGELVH IVDIDNGARLETYVIEGERGSGVIGINGAAAHLVHPGDLVILISYAQVDDAEARGLVPK VVHVDAGNRIVALGTDASAPVPGSRTERSPQAVVAGG" misc_feature 281..294 /note="TFBS match to MogR, Repressor of flagellar motility genes, confidence: weak, score: 12.75" /tool="antismash" gene 774..1127 /locus_tag="EES43_RS27415" /old_locus_tag="EES43_27050" CDS 774..1127 /EC_number="2.3.1.-" /GO_function="GO:0008080 - N-acetyltransferase activity [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018513131.1" /locus_tag="EES43_RS27415" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27050" /product="GNAT family N-acetyltransferase" /protein_id="WP_124271237.1" /transl_table=11 /translation="MAQNAGVEITDDREHGTLAAHDAGKVAGSIAYFVMEPAPGALVAV HTVVRPEHEGRGIAGALVREFYAMAAREGVPVVPLCPYAAKWAQRHPEEAPAASAELVR EAERQLGSHPELL" gene complement(1673..3037) /locus_tag="EES43_RS27425" /old_locus_tag="EES43_27055" CDS complement(1673..3037) /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) Orn_Arg_deC_N" /gene_functions="biosynthetic-additional (rule-based-clusters) Orn_DAP_Arg_deC" /gene_functions="biosynthetic-additional (smcogs) SMCOG1264: diaminopimelate decarboxylase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012378058.1" /locus_tag="EES43_RS27425" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27055" /product="diaminopimelate decarboxylase" /protein_id="WP_124271239.1" /sec_met_domain="Orn_Arg_deC_N (E-value: 2.2e-37, bitscore: 127.2, seeds: 15, tool: rule-based-clusters)" /sec_met_domain="Orn_DAP_Arg_deC (E-value: 6.1e-10, bitscore: 37.7, seeds: 500, tool: rule-based-clusters)" /transl_table=11 /translation="MKQTTSHHRERAAASSSDARFAGAVRAAVAQGLLSESHPLAGFID VDGVRSSVDSLREAFAGAPEVLHTFAAKASSLVPVLRLLAACGMGCEVASPGELRLALD AGFAPGSIVLDSPAKTREEIRLALALGVAVNADSLDELRRIDGLRRGDSASVIGLRVNP QVGEGAIGAMSTATATSKFGVALRDPGAREAILRAFEERPWLTRLHAHVGSQGCPLELI AAGVAQTYALAEEIDERLGVRQVTSLDIGGGLPVNFADDTVRPTYADYVSALTDAVPAL LSGRYALVTEFGRSLLAKNGVIGARVEYTKDAGGRRVALTHAGAQTATRTVFMPQAWPL RVGAFGPDGTPKDGPALAQDVAGPCCFAGDVVAHGRELPELAEGDFVVLYDTGAYYFST PWSYNSLPRPAVYGFRIVAGPDGGVVFATVRETQSMESIAEESGLGQAEALTGLG" gene complement(3147..4946) /locus_tag="EES43_RS27430" /old_locus_tag="EES43_27060" CDS complement(3147..4946) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018099989.1" /locus_tag="EES43_RS27430" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27060" /product="helix-turn-helix domain-containing protein" /protein_id="WP_124271240.1" /transl_table=11 /translation="MGSGAPPRDPGPEATLREVLAFDEEGALRLLLAPGGVDVEVRGVS FGDEAPRSRAGHLVLAVGASAGRAEAAGAVERAARSGASAVVLREAEEESGPGPAPDVL AAADRSGIALLVRAAWTDWTDTAALLRSALDYHRAARTGQARGADATGEATPGTAGDVP GRGGLECGGTEEAGPRGGGPGEGADPAAGGSDGPAGALAALAASIAEATGGSITIEDTR FRVLAHSATRPEADGVRRSTILGGRVPEWRVAELRRSGLLRTLWTSREVIHRPADGDSP ERLVIAVRSGAELLGSIWAAADGRPLSPEAGRALRRGAVVAARHLLGQRLRESGAVRRR DHALRGLLYGEGDRRTHAWSLGLAPDAPCAVLAVAPVAAGPDAARTLDVLAPHARAYRP SVLVLREPDRLLVLLPVPAGLPPEAREREALAPARELERVAAALPGGVPVRAGVGRVAG SAAEAAEACTEAALVVRVLRDRERRARGGGAPARFASAGAVGPALDVLRMAEAVRPLWE SGDGPVHRLARSDRAAGGELLRSAAAYLDAAGDVAEAARRLVLHPNTLRYRLRRLRERY DVDVDDPDTRVLLTLAVRLTGDV" gene complement(5001..5798) /locus_tag="EES43_RS27435" /old_locus_tag="EES43_27065" CDS complement(5001..5798) /GO_component="GO:0140737 - encapsulin nanocompartment [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) RiPP-like: Linocin_M18" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018955648.1" /locus_tag="EES43_RS27435" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27065" /product="family 1 encapsulin nanocompartment shell protein" /protein_id="WP_124271241.1" /sec_met_domain="Linocin_M18 (E-value: 1.7e-88, bitscore: 294.5, seeds: 61, tool: rule-based-clusters)" /transl_table=11 /translation="MNNLHRELAPVTPAAWAEIEEEARRTFTRHVAGRRVVDVTDPAGP TLAAVGDGHLRGIDPPTPDVLARARTSMPVVEWRVPFTVSREAVDDVERGSADSDWQPV KDAARTCAFAEDSAIIDGYASAGILGLRDGSSHTPLPLPADARDYPVAVSQAVTRLRLA GVDGPYRLLLGADAFTEAAETSDHGYPVKTHLSRLVDDDILWAPAVKGGLLLSTRGGDF ELCLGQDLSIGYTDHDATSVRLYFQQAFTFRMLTPEAVVALIA" gene complement(5798..6871) /locus_tag="EES43_RS27440" /old_locus_tag="EES43_27070" CDS complement(5798..6871) /GO_function="GO:0004601 - peroxidase activity [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_007456253.1" /locus_tag="EES43_RS27440" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27070" /product="Dyp-type peroxidase" /protein_id="WP_124271242.1" /transl_table=11 /translation="MPDAVPDPVAVQPVVAPLTSAALFLVGTIEPGGERTVREVLPELA AVARSIGFRYPDSGLACVTGFGSAAWDRLFAGPRPAHLHPFPELSGPLHHAPATPGDLL LHIRAERMDVCYEWAAQLLRKLGGALRIVDETQGFRYLDHRDLLGFVDGTENPVGDDAR AAALVGAEDPDFDGGSYVVVQKYLHDLDAWNALPVEEQERVIGRTKFDDVELPDEAKPS DSHVALNTITDPDGTERDILRANMPFGSFGRGEFGTYFIGYAADPDVTERMLRNMFLGD PPGSHDRILDFSTAITGTLFFAPRAAFLDAPPPPPAPPGAATRPKPVLAPVGPASAGTG SDDHGSLRIGSLQESAQ" gene complement(7058..8500) /gene="gndA" /locus_tag="EES43_RS27445" /old_locus_tag="EES43_27075" CDS complement(7058..8500) /EC_number="1.1.1.44" /GO_function="GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity [Evidence IEA]" /GO_function="GO:0050661 - NADP binding [Evidence IEA]" /GO_process="GO:0006098 - pentose-phosphate shunt [Evidence IEA]" /codon_start=1 /gene="gndA" /gene_functions="biosynthetic-additional (smcogs) SMCOG1100: 3-hydroxyisobutyrate dehydrogenase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015612845.1" /locus_tag="EES43_RS27445" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27075" /product="NADP-dependent phosphogluconate dehydrogenase" /protein_id="WP_124271243.1" /transl_table=11 /translation="MSGTAQIGVTGLAVMGRNLARNFARNGFTVAVHNRTASKTDALVG EFGGEGAFVAAHTPEEFVAALERPRRLVVMVKAGDPTDAVIQEFAPLLEEGDVIIDGGN AHFEDTRRREKELRERGVHFVGAGISGGEEGALHGPSIMPGGSAESYASLGPLLERIAA KAKDGTPCTAHIGPDGAGHFVKMVHNGIEYADMQLIAEAYDLLRRVAGYSPARIAETFR SWNTGRLDSYLIEITAEVLAHTDADTGEPFVDIVQDRAEQKGTGRWTVQIALDLGVPVS GIAEAVFARSLSGHADLREAARGLPGPSAKPLEGAQAAAFADRVEQALYASKIVSYTQG FHQIRVGSDTYGWDVDLGSVAAIWRAGCIIRAAFLDRIRAAYASRPDLLSLLSDEEFER EIGAAQDDWRAVVAESARQGVPTPGFAAALAYYDGLRADRLPAALTQGQRDFFGAHTYR RTDRKGIFHTLWGGDRSEVTGG" gene complement(8600..9076) /locus_tag="EES43_RS27450" /old_locus_tag="EES43_27080" CDS complement(8600..9076) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_006129107.1" /locus_tag="EES43_RS27450" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_27080" /product="DUF5709 domain-containing protein" /protein_id="WP_124271244.1" /transl_table=11 /translation="MSDTEWGDEVYQPQEPPGSDFDEQLDTGDTLEDSGVDDPLDEGYS PPERPWAVEDRGTTAAEQRTGESLESRLTRELPEVAEWPGDGVGDLAGGEGEPWDDEVG VDRAGRLTQQADGRVPAAATADDVGVDGAAASAEEAAVHVVPDDDAPPAAEALP" misc_feature 9094..9109 /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 17.54" /tool="antismash" ORIGIN 1 cgccggcgtg gccgccgtcc tcacgaggag cagccgctca cggacatgcg gtcgccatcg 61 aggtggaggg cacttcgtcc tacgggtccg gcttcgccca gaccgcccgg tcgcacgggc 121 accaggtcgt cgaggtcgac cgccccgtca gcgggagtca tgaaaaacct ggggaacggt 181 gccctgacat gcgcctcgtt gtagggtgag gacaacgccc ttgacctgca aaaacgcagg 241 cagggagcct atgtccagga gtgccttcat gttgcgcacc atgttcaaat ccaagatcca 301 ccgggccacc gtcacccagg ccgacctgca ctacgtcggt tccgtgacga tcgacggcga 361 cctgatggag gccgccgacc tgctgcccgg cgaattggtc catatcgttg acatcgacaa 421 cggcgcgcgg ctggagacgt acgtcatcga gggcgagcgc ggctccggcg tcatcgggat 481 caacggggcc gccgcccacc tggtgcaccc cggggatctg gtgatcctca tcagctacgc 541 gcaggtcgac gatgcggagg cgcgcggtct cgtcccgaag gtcgtccacg tcgacgccgg 601 caaccggatc gtggcgctcg gcacggacgc ctccgcgcct gtccccggtt cccgtaccga 661 gcggagcccg caggccgtcg tcgcgggcgg ctgacaccgc cgcctgccca cgccccgccc 721 ccccggccac ggaaacgcgg ccgggggcac cacgaacgag gagagcagga accatggcgc 781 agaacgccgg tgtggagatc acggacgacc gggagcacgg caccctcgcg gcgcacgacg 841 cgggcaaggt cgccggaagc atcgcgtact tcgtcatgga acccgcgccc ggggcgctcg 901 tggccgtgca caccgtcgtc cggcccgaac acgagggcag gggcatcgcc ggtgcgctgg 961 tccgcgagtt ctacgccatg gccgcccgcg agggcgtccc cgtcgtgccg ctgtgcccgt 1021 acgcggcgaa gtgggcgcag cgccatcccg aggaggcccc cgccgcgtcg gccgaactgg 1081 tccgggaggc ggagcggcag ctggggagcc accccgagct gctctgagtc cgggccggtc 1141 gatggcgcgg tgcgccacac gacgggcacg agtggatcac gtgtggagtc ggcaggcgcg 1201 ggcagccgca ccgggagacg gtggaggaga gctccgcccg tccgtttcgt accgctgtgg 1261 aggatcgtga tgacccaccc gtaccccgac cccgtaccgc cctcgccgac gcctccgccc 1321 gttcccgggc ctcccactcc ggtgcccggt ccgcctcccg tcccgccggg gcccgggcct 1381 gtgccgcccg gtcccgcgcc ggacccgatt ccgccgtcgc ccggcccgga ccccacgccc 1441 gacccggagc cccagcccgc cggctgaacc cggccgggcc cgagccggcc caagccggtg 1501 aggcgagaag cgtggattcc gctcaggcac cgacgggcgc cggccccctg ccgggccggc 1561 gcccgccccc tccacgtccg gccgaagccg ggcgtatgac gggaacccgg cgtgcgatgg 1621 gaacctggcg gcagccggcc ccacgaccgg catcggcccg gaaccggggg cgtcagccca 1681 gaccggtcag cgcctccgcc tgcccgaggc cgctctcctc cgcgatcgac tccatcgact 1741 gcgtctcgcg caccgtcgcg aacaccaccc cgccgtccgg ccccgccacg atccggaacc 1801 cgtacaccgc gggccgcggc aggctgttgt aggaccacgg agtggagaag tagtacgccc 1861 ccgtgtcgta cagcacgacg aagtcccctt cggccagctc cggaagctcc ctgccgtgcg 1921 ccaccacgtc tcccgcgaag cagcacggcc ccgcgacgtc ctgcgccagt gccggcccgt 1981 ccttcggtgt tccgtccggg ccgaacgcac cgacgcgcaa cggccacgcc tgaggcatga 2041 agacggtacg ggtggcggtc tgcgcgcccg cgtgggtgag ggcgacgcgc cgtccgcccg 2101 cgtccttcgt gtactccacc cgcgccccga tgaccccgtt cttcgccagc agtgaccggc 2161 cgaactcggt gaccagggcg taccggccgg acaggagcgc gggaacggcg tcggtcaggg 2221 cgctgacgta gtcggcgtag gtcgggcgca cggtgtcgtc ggcgaagttg acgggcagcc 2281 cgccgccgat gtccaggctg gtcacctgcc ggacgccgag gcgttcgtcg atctcctcgg 2341 ccagcgcgta cgtctgcgcc acccctgccg cgatcagctc caacgggcag ccctgggacc 2401 cgacatgcgc gtgcagccgg gtgagccacg ggcgctcctc gaaggcccgc aggatcgcct 2461 cgcgggcccc ggggtcgcgc agcgccacgc cgaacttcga cgtcgcggtc gccgtgctca 2521 tcgccccgat cgcaccctcg cccacctgcg ggttgacgcg cagtccgatc acggaggcgc 2581 tgtcgccgcg ccgcagtccg tcgatccggc gcagctcgtc cagactgtcg gcgttgacgg 2641 cgaccccgag ggccagcgcc agccggatct cctcgcgggt cttggccggg gagtccagga 2701 cgatcgaccc cggcgcgaac ccggcgtcca gggcgagccg cagctcaccc gggctcgcca 2761 cctcgcaccc catgccgcat gcggcgagca gccgcagcac cggaacgagg gacgaggcct 2821 tggccgcgaa cgtgtgcagg acctcgggcg cgcccgcgaa cgcctcgcgc agggagtcga 2881 cggacgagcg caccccgtcc acgtcgatga acccggccag cgggtgggac tcgctcagca 2941 gcccctgcgc cacggccgcc cggacggccc cggcgaaccg ggcgtcggac gacgaggcgg 3001 cggcccgctc acggtgatgg gaagtcgtct gcttcatgat gcgaggatcg gtgatggctg 3061 ccccacaggt cttcagcggc acggacaaca ctctccgcat tccttggccg agcggacaac 3121 ccgcgccgcg aaaagggccg gaccgctcaa acgtcacccg tgaggcggac ggccagcgtc 3181 agcagcaccc gtgtgtccgg gtcgtccacg tcgacgtcgt accgctcccg cagccgccgc 3241 agccggtagc ggagggtgtt cgggtgcagg accagccggc gtgccgcctc cgccacgtcg 3301 cccgcggcgt ccagatacgc ggcggccgac cgcagcagtt cgccgcccgc cgcccggtcg 3361 gaccgcgcca gccggtgcac cggcccgtcg ccggactccc acaacggccg taccgcctcc 3421 gccatccgca gcacgtccag cgccggcccc accgcacccg ccgacgcgaa ccgcgccggc 3481 gcgccaccgc cccgcgcccg ccgctcgcgg tcccgcagca cccgcacgac cagggcggcc 3541 tccgtgcacg cctcggccgc ctccgccgcc gatccggcca cccggcccac cccggcccgt 3601 accggaactc cgccgggcag cgccgccgcc acccgctcca gctcccgggc cggcgcgagc 3661 gcctcccgct cacgcgcctc gggcggcagc ccggcgggaa cggggagcag gaccaggagg 3721 cgatccggtt cgcgcaggac cagtaccgag ggccggtacg cccgtgcgtg cggggcgaga 3781 acgtccaggg tccgcgccgc gtccggcccg gcggcgaccg gcgcgaccgc cagcaccgcg 3841 cagggcgcgt cgggcgccag ccccagcgac caggcgtgcg tgcggcggtc cccctctccg 3901 tacaggagtc cgcgcagcgc gtggtcgcgg cggcgcaccg caccgctctc ccgcagccgc 3961 tgcccgagca ggtgccgcgc cgccaccacc gcaccgcgcc gcagcgcccg gccggcctcc 4021 ggcgagaggg gcctgccgtc cgccgccgcc cagatggagc ccagcagctc ggctccgctg 4081 cgtacggcga tgaccagccg ctccggactg tcgccgtccg ccgggcggtg gatcacctcc 4141 cgtgacgtcc acagcgtccg cagcagcccg ctgcgccgca gttcggcgac gcgccactcg 4201 gggacgcgac cgcccaggat ggtggacctg cgcaccccgt cggcctcggg ccgggtggcc 4261 gagtgcgcca gtacgcggaa acgggtgtcc tcgatggtga tggagccgcc cgtcgcctcg 4321 gcgatcgacg cggccagcgc ggccagcgcg cccgccgggc cgtcgctccc gccggccgcc 4381 ggatccgccc cctcgccggg cccgccgccc ctcggcccgg cctcctccgt cccgccgcat 4441 tccagcccgc cgcgtcccgg cacgtcgcct gccgtgccgg gtgtcgcctc gcctgtcgcg 4501 tccgcgcccc gcgcctgacc ggttctcgcc gcccggtggt agtccagcgc cgaacgaagc 4561 agcgccgcgg tgtcggtcca gtccgtccag gccgcccgta ccagcagtgc gatgccggac 4621 cggtccgccg cggcgagcac gtccggggcc ggaccgggac cggattcctc ctccgcctcc 4681 cgcagcacca cggcgctcgc gcccgagcgc gccgcccgct ccaccgcccc ggccgcctcg 4741 gcccgtccgg cggacgcccc gacggcgagg acgaggtgcc cggcgcggct ccgcggcgcc 4801 tcgtcgccga acgacacgcc ccggacctcc acgtccactc cgccgggcgc cagcagcagg 4861 cgcagcgcgc cctcctcgtc gaacgccaga acctcccgga gcgtggcctc cggccccgga 4921 tcccgcggcg gtgctccact gcccatgact cccgagcata cgagcgtcga cggcgggtgc 4981 gcggggcacg gggcacgggc tcaggcgatc agggcgacca cggcctccgg cgtcagcatc 5041 cggaaggtga aggcctgctg gaagtagagc cggacgctgg tcgcgtcgtg gtcggtgtag 5101 ccgatcgaca ggtcctggcc caggcacaac tcgaagtcgc cgccccgggt ggacaggagc 5161 aacccgccct tcaccgcggg cgcccacagg atgtcgtcgt ccacgaggcg gctcaggtgc 5221 gtcttgaccg gatagccgtg gtcggaggtc tcggccgcct cggtgaaggc gtccgcgccg 5281 agcagcagcc ggtacggacc gtcgacgccg gccagccgca gccgcgtcac cgcctgactg 5341 accgccaccg ggtagtcccg cgcgtcggcg ggcagcggca gcggcgtgtg cgaggagccg 5401 tcgcgcagcc cgaggatccc ggcggacgcg tagccgtcga tgatcgccga gtcctccgcg 5461 aacgcacagg tgcgcgccgc gtccttgacg ggctgccagt cgctgtcggc ggagccgcgt 5521 tccacgtcgt ccacggcctc ccggctcacc gtgaagggca cacgccactc gacgaccggc 5581 atcgacgtgc gggcgcgggc cagcacgtcc ggggtgggcg ggtcgatgcc gcgcagatgg 5641 ccgtcgccga cggcggccag cgtcggaccc gccggatcgg tcacgtcgac gacacgccgg 5701 ccggccacat ggcgggtgaa ggtgcgccgc gcctcctcct cgatctccgc ccaggcggcg 5761 ggggtgacgg gcgcgagttc gcggtgcaga ttgttcatca ctgggcgctt tcttgcaggc 5821 tgccgatgcg cagcgaaccg tggtcgtccg atccggtccc ggcggacgcc ggccccaccg 5881 gtgcgagcac cggttttggc cgggtcgcgg ccccgggcgg ggcgggcggg ggcgggggag 5941 cgtcgaggaa ggcggcgcgg ggggcgaaga acagggtgcc ggtgatcgcg gtggagaagt 6001 cgaggatgcg gtcgtgcgaa ccgggcggat cgccgaggaa catgttgcgg agcatccgtt 6061 cggtcacgtc gggatcggcc gcgtagccga tgaagtacgt cccgaactcc ccccggccga 6121 agctcccgaa cggcatgttc gcccgcagga tgtcgcgctc ggtcccgtcc ggatcggtga 6181 tcgtgttgag cgcgacgtgc gagtcggagg gcttggcctc gtcgggcagc tccacgtcgt 6241 cgaacttggt gcggccgatg acccgttcct gctcctccac gggcagggcg ttccaggcgt 6301 ccaggtcgtg caggtacttc tgcacgacca cgtagctccc gccgtcgaag tccgggtcct 6361 ccgcgccgac gagcgccgcc gcgcgggcgt cgtcgcccac cgggttctcc gtaccgtcca 6421 cgaaaccgag caggtcccgg tggtcgaggt agcggaaccc ctgcgtctcg tccacgatcc 6481 gcagcgcccc gccgagcttc cgcaggagct gggcggccca ctcgtagcag acgtccatcc 6541 gctcggcccg gatgtgcagc agcaggtcgc cgggggtcgc gggcgcgtgg tggagcggcc 6601 cgctcagctc cgggaacggg tgcaggtgcg cggggcgcgg tccggcgaag agccggtccc 6661 aggcggcgga cccgaagccg gtcacgcacg ccaggccgga gtccggatac cggaagccga 6721 tggagcgggc gacggccgcc agctccggca gcacctcgcg caccgtgcgc tcgccgcccg 6781 gttcgatcgt gccgaccagg aacagggcgg cgctggtcag cggggcgacg acgggctgga 6841 ccgcgaccgg gtccgggacg gcatcgggca tgcgcgcact cctgggacgg gtgacgacgg 6901 gcggacggtg tacggccggg cggttgccgg tcgcacggta gggcgggcgg gacggccggg 6961 gtgcggagcc acgacggcac cgcagcacgg cggtccgggc ccgcaagcca cttacgcacg 7021 ctccgggccc cgccgcaccc cgggtggccc ggtcgggtca gccgcccgtg acctcggacc 7081 ggtccccgcc ccagagcgtg tggaagatcc ccttccggtc cgtgcgccgg taggtgtgcg 7141 ccccgaagaa gtcccgctgc ccctgcgtca gcgccgcggg cagccggtca gcgcgcagtc 7201 cgtcgtagta cgccagcgcc gccgcgaaac cgggcgtcgg cacgccctgg cgcgccgatt 7261 cggcgaccac cgcccgccag tcgtcctgtg ccgcaccgat ctcccgctcg aactcctcgt 7321 ccgacagcag gctcagcagg tcgggccgcg aggcgtaggc ggcccggatc cggtccagga 7381 acgccgcccg gatgatgcag cccgcccgcc agatcgccgc cacggaaccg aggtccacat 7441 cccagccgta ggtgtcgctg ccgacccgga tctggtggaa gccctgcgtg tacgagacga 7501 tcttggaggc gtacagggcc tgctcgaccc ggtccgcgaa cgccgccgcc tgcgcgccct 7561 ccaacggctt cgcggagggt cccggcagtc cgcgcgcggc ctcccgcagg tccgcgtggc 7621 ccgagaggga gcgggcgaac accgcctcgg cgatccccga caccggcacc ccgaggtcca 7681 gcgcgatctg cacggtccag cgcccggtgc ccttctgctc ggcccggtcc tggacgatgt 7741 cgacgaacgg ctcgccggtg tccgcgtccg tatgggccag gacctcagcg gtgatctcga 7801 tcaggtacga gtcgaggcgt ccggtgttcc agctccggaa cgtctccgcg atccgcgcgg 7861 gagagtagcc ggccacgcgg cgcagcaggt cgtacgcctc ggcgatgagc tgcatgtccg 7921 cgtactcgat gccgttgtgg accatcttca cgaagtgacc ggccccgtcc ggcccgatgt 7981 gcgcggtgca cggcgtgccg tccttcgcct tcgcggcgat cctctccagc agcggaccga 8041 gcgacgcgta ggactcggcc gagccgcccg gcatgatgct cggaccgtgc agcgcgccct 8101 cctcgccgcc cgagatgccc gccccgacga agtggacgcc gcgctcgcgc agctccttct 8161 cacggcggcg ggtgtcctcg aagtgggcgt tcccgccgtc gatgatgacg tcgccctcct 8221 ccagcagcgg ggcgaactcc tggatcacgg cgtcggtggg atcaccggcc ttcaccatga 8281 cgaccagacg ccggggcctc tccagcgcgg cgacgaactc ctcgggcgtg tgcgccgcga 8341 cgaacgcgcc ctcgccgccg aactccccga cgagcgcgtc ggtcttggac gccgtgcggt 8401 tgtgcacggc gacggtgaag ccgttgcggg cgaagttccg ggcgaggttg cggcccatca 8461 ccgcgagtcc ggtgacgccg atctgggcag taccgctcat ctgagtgctc ctgcgatccg 8521 gggtgggttc ggtcggggaa gtgccggggg gcgtacggga cgggggacgg ccgcgacggc 8581 cgcgttcaaa cggtcgcgtt caggggaggg cctccgcggc gggcggagcg tcgtcgtcgg 8641 ggaccacgtg cacggcggcc tcctcggccg aggccgccgc gccgtcgacg cccacgtcgt 8701 cggcggtcgc cgcggcgggg acccggccgt cggcctgctg cgtcagccgt ccggcgcggt 8761 cgaccccgac ctcgtcgtcc cagggctcgc cctcaccgcc ggccaggtcg cccacgccgt 8821 cgccgggcca ctccgcgacc tcggggagtt ccctggtcag ccgggactcc agggactcgc 8881 cggtgcgctg ctccgcggcg gtggtgcccc ggtcctcgac cgcccacggg cgttcgggcg 8941 gcgagtagcc ctcgtcgagc gggtcgtcca ccccggagtc ctccagcgtg tccccggtgt 9001 cgagctgctc gtcgaaatcg gagcccggcg gctcctgcgg ctggtagacc tcgtcccccc 9061 actcggtgtc gctcatggcc cgtcctttcg tcccacgaga atcactgtcc cctgtacgca 9121 attccactcc ggtaacgccg ctgccgcaaa gggaagatcc tcatccagtg gtcggccgag 9181 gccgacccgc gccccgaggg cagggcgcgc acgggtgcac gagcgcccgc acgcgggccg 9241 tggccccggg gccggcacgt acactcggcc catgggtcgt gaagccgaac cgcggaagtg 9301 cccgcaccgg gcggcctccg cgctgcacgg acacggctag cgaccttcgg ccacggctgg 9361 cgaccttcgg cgtccagcgt ccggggcgtc tcagcccgta gggctcgcat cggcccgttc 9421 ctcttgcttc cgcccgcttt cagccctgtg cgcccgagcc ctttccgcgt tgctccgccc 9481 cgcccccggg cgcgggcgcg gtgcgacccg tggcctccac cggcgccaca cgtttccgca 9541 cgcatcacgc atcacgcatc acgcatcacg catcacgcat cacgcatcac gcatcacgca 9601 tcacgcatca cgcggcacac cgcgcatccg cccgtgccgc cgcccggcga cggccgcacc 9661 accggggccg ccgccgctct cgaagggacc accgtgaagc tgagcgacct cctggcaggc 9721 caggaccatc acgtactccg gggagatccc cggcggaccg agatcaccgc cggtgccacg 9781 ttcgacgcgg accgcgtcac ccccggctcc gtcttcgcag ccgtgccggg ccacctcacg 9841 ggcggccccg aagccctggc gcccgccgtc gcccgcggtg cggtcgccgt cctggtcgac 9901 gaccaggcgc cgcccctgcc cgccgcgacg ggccacgtct gcgccgtccg ggtgccggac 9961 gtccgcaagg ccgccgccgt cgtcgcggca cgctacttcg gcgagccggg ccgcgccatg 10021 gagctgatcg ccgtcaccgg gaccaacggc aagacctccg tgtcgtacat ggtcgagtcc 10081 gtgctgcgga tcgccgaggg cgtccgggtc ggcgtgatcg gtacggcggg aagccggatc 10141 ggggacgagc ccgtcccgat gccgccctcg gtgctcacca ccccggagtc gcccgatctc 10201 cagtacctgc tgggacacat gcgcgaccgc gccaccggca gcgtcgtcct ggaggccacc 10261 tccatgggcc tgctgacgca ccgtctggac cgtacgttca tcgacgtcgg cgtcttcacg 10321 aacctgacgc aggaccacct cgacgaccac ggcaccatgg agaactaccg cgacgccaaa 10381 ctccgcctct tccagggcct gtgccggcga gcggtgatca acgccgacga cccggtgggc 10441 gccgggatcc gggcgctgat gcccgacgcg gtgaccacgt acgcgctgga cgccgacgcc 10501 gactaccggg cgagcgacct ggtcgtggac gcctcgggaa cgcgtttcac cctgcaccac 10561 gacgggcgca agtatccggc ggccattccg tcgcccggcc ggttctcggt ctccaacgcc 10621 ctggccacgc tggccgcctg ccatcttctg ggccacggcc tggccgggct cgtcgacgcc 10681 ctggagcgca tgccgcagat ccccggacgc ttcgaacgcc tccaggcccc gaacggcgcc 10741 tcggtgatcg tcgactacgc gcactcgccg gactccctcg acaaggtgct caccacga //