LOCUS NZ_ML123034 84826 bp DNA linear CON 23-MAY-2024 DEFINITION Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun sequence. ACCESSION NZ_ML123034 VERSION NZ_ML123034.1 KEYWORDS WGS; RefSeq. SOURCE Streptomyces sp. ADI96-02 ORGANISM Streptomyces sp. ADI96-02 Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces. REFERENCE 1 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Streptomyces spp. from the marine sponge Antho dichothoma: analyses of secondary metabolite biosynthesis gene clusters and some of their products JOURNAL Unpublished REFERENCE 2 (bases 1 to 6907715) AUTHORS Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C., Busche,T., Kalinowski,J. and Zotchev,S.B. TITLE Direct Submission JOURNAL Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1, Bielefeld 33615, Germany COMMENT ##Genome-Assembly-Data-START## Assembly Method :: Newbler v. 2.8 Genome Representation :: Full Expected Final Version :: Yes Genome Coverage :: 64.8x Sequencing Technology :: Illumina MiSeq ##Genome-Assembly-Data-END## ##Genome-Annotation-Data-START## Annotation Provider :: NCBI RefSeq Annotation Name :: GCF_003846185.1-RS_2024_05_23 Annotation Date :: 05/23/2024 03:48:04 Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline (PGAP) Annotation Method :: Best-placed reference protein set; GeneMarkS-2+ Annotation Software revision :: 6.7 Features Annotated :: Gene; CDS; rRNA; tRNA; ncRNA Genes (total) :: 6,089 CDSs (total) :: 6,032 Genes (coding) :: 5,843 CDSs (with protein) :: 5,843 Genes (RNA) :: 57 tRNAs :: 54 ncRNAs :: 3 Pseudo Genes (total) :: 189 CDSs (without protein) :: 189 Pseudo Genes (ambiguous residues) :: 0 of 189 Pseudo Genes (frameshifted) :: 68 of 189 Pseudo Genes (incomplete) :: 155 of 189 Pseudo Genes (internal stop) :: 10 of 189 Pseudo Genes (multiple problems) :: 42 of 189 CRISPR Arrays :: 2 ##Genome-Annotation-Data-END## ##antiSMASH-Data-START## Version :: 8.dev-cf2fc5ee(changed) Run date :: 2025-09-13 01:00:53 NOTE :: This is a single region extracted from a larger record! Orig. start :: 5353009 Orig. end :: 5437835 ##antiSMASH-Data-END## REFSEQ INFORMATION: The reference sequence is identical to ML123034.1. The annotation was added by the NCBI Prokaryotic Genome Annotation Pipeline (PGAP). Information about PGAP can be found here: https://www.ncbi.nlm.nih.gov/genome/annotation_prok/ Bacteria and source DNA available from Zotchev Lab, Department of Pharmacognosy, University of Vienna. Annotated using prokka v1.11 from http://www.vicbioinformatics.com. FEATURES Location/Qualifiers region 1..84826 /candidate_cluster_numbers="1" /candidate_cluster_numbers="2" /candidate_cluster_numbers="3" /candidate_cluster_numbers="4" /candidate_cluster_numbers="5" /contig_edge="False" /product="T1PKS" /product="hglE-KS" /product="NRPS" /product="lanthipeptide-class-i" /product="lanthipeptide-class-ii" /region_number="21" /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /rules="(hglE or hglD)" /rules="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /rules="(((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))" /rules="cds(LANC_like and DUF4135)" /tool="antismash" cand_cluster 1..44719 /SMILES="NC([*])C(=O)NC(CCC(=O)N)C(=O)CC(=O)C([*])C(-O)" /candidate_cluster_number="1" /contig_edge="False" /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /kind="single" /product="T1PKS" /protoclusters="1" /tool="antismash" protocluster 1..44719 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[20000:24719](-)" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" /tool="antismash" proto_core complement(20001..24719) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))" /neighbourhood="20000" /product="T1PKS" /protocluster_number="1" misc_feature 4064..4077 /note="TFBS match to CatR, H2O2-responsive repressor, confidence: weak, score: 17.99" /tool="antismash" cand_cluster 4721..84826 /SMILES="C([*])C(-O)CC(=O)NC([*])C(=O)NC(CCC(=O)N)C(=O)NC(C (O)C)C(=O)NC(C(C)C)C(=O)O" /candidate_cluster_number="2" /contig_edge="False" /detection_rules="(hglE or hglD)" /detection_rules="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))" /detection_rules="cds(LANC_like and DUF4135)" /kind="neighbouring" /product="hglE-KS" /product="NRPS" /product="lanthipeptide-class-i" /product="lanthipeptide-class-ii" /protoclusters="2" /protoclusters="3" /protoclusters="4" /protoclusters="5" /tool="antismash" cand_cluster 4721..51761 /SMILES="C([*])C(-O)CC(=O)NC([*])C(=O)NC(CCC(=O)N)C(=O)NC(C (O)C)C(=O)NC(C(C)C)C(=O)O" /candidate_cluster_number="3" /contig_edge="False" /detection_rules="(hglE or hglD)" /kind="single" /product="hglE-KS" /protoclusters="2" /tool="antismash" protocluster 4721..51761 /aStool="rule-based-clusters" /category="PKS" /contig_edge="False" /core_location="[24720:31761](-)" /cutoff="20000" /detection_rule="(hglE or hglD)" /neighbourhood="20000" /product="hglE-KS" /protocluster_number="2" /tool="antismash" proto_core complement(24721..31761) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(hglE or hglD)" /neighbourhood="20000" /product="hglE-KS" /protocluster_number="2" misc_feature complement(8392..8411) /note="TFBS match to DosR, Hypoxia stress response regulator, confidence: weak, score: 23.38" /tool="antismash" misc_feature 10058..10073 /note="TFBS match to ColR, Phenol-responsive regulator, confidence: weak, score: 17.53" /tool="antismash" misc_feature complement(12946..12959) /note="TFBS match to ANR, Anaerobic transcriptional regulator, confidence: weak, score: 19.61" /tool="antismash" misc_feature 13186..13200 /note="TFBS match to MexT, Global virulence regulator, confidence: weak, score: 15.36" /tool="antismash" misc_feature 13431..13445 /note="TFBS match to VqsM, Regulator of quorum-sensing signalling systems, confidence: medium, score: 17.8" /tool="antismash" gene 13794..14438 /locus_tag="EES43_RS23545" /old_locus_tag="EES43_23160" CDS 13794..14438 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015579112.1" /locus_tag="EES43_RS23545" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23160" /product="type VII secretion system-associated protein" /protein_id="WP_124270563.1" /transl_table=11 /translation="MTESRVETPASLLDPPPPEEFVQAARLAPGHWLHLTDPAWPGEGA PPDWAVVGRWRSDAAGEIVEWEDNEEYRPSPEAMGWPEPADDVDRAIQLATTGYGPAED VTAALARAEVAVPVTASGDPVSMSAPDGTAVVPAYTSPRYLQGLGQLGSVTLPVVDLLT RIPADHSLCLNSSAAVSMVLTTEGLADVLAEAATKGRKAEDTPEAAGQPNR" misc_feature 14854..14870 /note="TFBS match to NuR, Nickel-responsive regulator, confidence: weak, score: 19.95" /tool="antismash" misc_feature 14950..14965 /note="TFBS match to FuR_variant_1, Ferric Uptake Regulator, confidence: weak, score: 15.48" /tool="antismash" gene 14951..16330 /locus_tag="EES43_RS23550" /old_locus_tag="EES43_23165" CDS 14951..16330 /GO_function="GO:0030246 - carbohydrate binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: protein motif:HMM:NF012859.4" /locus_tag="EES43_RS23550" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23165" /product="RICIN domain-containing protein" /protein_id="WP_124270564.1" /transl_table=11 /translation="MKFMLTPRRRTALALVGAASLLWPVLSPVSPPASASAGSYDLLYD PGPSHNCWGRIVDDDPNKSDPTRVNTSGCGPFAADKEFQRSVNQPEKSPTWDMGTLGWN TADWGRTPGFSFSAQTGSKTVNMTNSAANSDCGPLRETNVSYTYQNSQLRWGSDRKKLT LGDGNVNVSYNASVRQSGSFTCPEKRAILTTDFIFDDLKNRETALISVVHYDAQNAFTG PVAGDLVWNTLNPDGKSCQAGYGCRVMVKSPTGMLGEGQNGLVSDNISALFDQYARYLN PGNLPKSNFSFRGLQIVSSNRGTSTTSSVSKVSATLTPNGPVTTTLRNRDKQGNLCLDV NNNQQTSPADAQIYTCNTSSAQRWTVGPDNTLRANGLCLDAEGAGTANGTDVNLWTCNG GQNQKWVLGRYGQVYNPVSGRCLEVAGGSSQSGYSDLQLYDCWGGVNQKWWTPYGDFHD Q" misc_feature 14952..14966 /note="TFBS match to ZuR_variant_1, Zinc-responsive repressor, confidence: weak, score: 19.55" /tool="antismash" gene complement(16530..17630) /locus_tag="EES43_RS23555" /old_locus_tag="EES43_23170" CDS complement(16530..17630) /EC_number="2.1.1.-" /GO_function="GO:0008168 - methyltransferase activity [Evidence IEA]" /GO_function="GO:1904047 - S-adenosyl-L-methionine binding [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010356771.1" /locus_tag="EES43_RS23555" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23170" /product="class I SAM-dependent methyltransferase" /protein_id="WP_241192511.1" /transl_table=11 /translation="MNAVSREDRTLRVAALRAAYREELAEGTDAFFAPRARACPWCGSN RLTGRLHTADLLQHKPGAFELDRCDACGHVFQNPRLNERGLAFYYRDFYDGLGEEKLGG VFDGRAAAYRSRAESVRPHLGGAAEWLDVGTGHGHFCETARAVLPAVAFDGIDRTDGAD LAERAGRVRRGHRGSLPELAARQPGSYDVVSMFHCLEHCTSPQRELEAAHAVLRPGGLL VIDVPDPESRFARLLGRWWLPWLQPQHLHLVPAGNLRRRLAECGFTVLAEEHAEAHDPV DLLAAVWSALNAVAPREDLPWLDAPPGAGRRALRTAVMIAGVPLLLAAAVLDRVVVRPF AGPLRLANAYRLVARRDADGGPPTPG" gene complement(17627..18844) /locus_tag="EES43_RS23560" /old_locus_tag="EES43_23175" CDS complement(17627..18844) /GO_function="GO:0016757 - glycosyltransferase activity [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) MGT" /gene_functions="biosynthetic-additional (smcogs) SMCOG1062: glycosyltransferase, MGT family" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_019062830.1" /locus_tag="EES43_RS23560" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23175" /product="glycosyltransferase" /protein_id="WP_124270565.1" /sec_met_domain="MGT (E-value: 7.7e-44, bitscore: 149.0, seeds: 193, tool: rule-based-clusters)" /transl_table=11 /translation="MSRFLFVVPPLVGHINPAVGVAAVLASRGHRVAWAGEPALIRRLA GPDAVVHPCPPPGSELGWEEGPVAGRPPDVRGPEALRFLWERFLVPLAEAMAPGVRQAV AAFRPDVVVADQQAMAGALVAEDLGLPWATSATTSAEFADVLATMPRVAAWNEALLRDL RARIGDPAGSGDPRFSPHLVLAFTTPELAGPAARGGDRVRWVGPSLTARPFPAAFPWDR LDPGRRLVLVTLGTANTDVGARFLGRAAEALRARADRVQAVIVDPEGTLAGSAPGGPDR ERDVIALPAIPQLELLERADAVVCHAGHNTVCEALWHGVPLVVAPIRDDQPVVAAQVAD AGAGVRIRFGRSGADAIGAAVDTVLDEPHPRAAARTIARAFRDAGGAPAAARHLERLAD GRMEDK" gene complement(18841..19677) /locus_tag="EES43_RS23565" /old_locus_tag="EES43_23180" CDS complement(18841..19677) /GO_function="GO:0016787 - hydrolase activity [Evidence IEA]" /NRPS_PKS="Domain: Abhydrolase_1 (30-150). E-value: 3.1e-27. Score: 87.7. Matches aSDomain: nrpspksdomains_EES43_RS23565_Abhydrolase_1.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036: alpha/beta hydrolase fold protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017947011.1" /locus_tag="EES43_RS23565" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23180" /product="alpha/beta hydrolase" /protein_id="WP_124270566.1" /sec_met_domain="PF00561 (E-value: 7.3e-23, bitscore: 80.0, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 5.4e-20, bitscore: 71.4, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MAIIDTGDVRLHVQRLAPSPAAGPGAAAGATVVLLHGLLTDSLAS YYFTVAPAFAAAGLDVVMYDHRGHGRSGRPDRGYTLGAFTDDLDALLDRLDVGGPVHLV GNSYGGTVAFDYALRRPERVAGMVVIESEPATGAWAAKLAGLLGRVRHEMSVNEDAALD WIAAHHGGHTARLAKSAAQLVRDTTIARDIPASAVMGDDDVRAIDCPVLALYGADSDLA AQAPRMRSLLPHCTTELLPGHQHSVLVEAPGRVRDLVLDWVGRHSRPAVADRVGVR" aSDomain complement(19228..19587) /aSDomain="Abhydrolase_1" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23565_Abhydrolase_1.1" /evalue="3.10E-27" /label="EES43_RS23565_Abhydrolase_1.1" /locus_tag="EES43_RS23565" /protein_end="150" /protein_start="30" /score="87.7" /tool="antismash" /translation="TVVLLHGLLTDSLASYYFTVAPAFAAAGLDVVMYDHRGHGRSGRP DRGYTLGAFTDDLDALLDRLDVGGPVHLVGNSYGGTVAFDYALRRPERVAGMVVIESEP ATGAWAAKLAGLLGRV" CDS_motif complement(19327..19383) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23565_0001" /evalue="4.40E-06" /label="NRPS-te1" /locus_tag="EES43_RS23565" /protein_end="117" /protein_start="98" /score="19.2" /tool="antismash" /translation="GPVHLVGNSYGGTVAFDYA" gene complement(19681..20004) /locus_tag="EES43_RS23570" /old_locus_tag="EES43_23185" CDS complement(19681..20004) /NRPS_PKS="Domain: PP-binding (25-86). E-value: 2.1e-07. Score: 23.1. Matches aSDomain: nrpspksdomains_EES43_RS23570_PP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_017947010.1" /locus_tag="EES43_RS23570" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23185" /product="phosphopantetheine-binding protein" /protein_id="WP_124270567.1" /sec_met_domain="PP-binding (E-value: 2.7e-06, bitscore: 26.2, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTTPHPTGSVRADEAAVLADLTAMIEQVLEDYGLDDTEITMETRF GRDLELESIDLVTLAGLLEERYGRLVNFAEFVSSMELDEIIELSVGRLVEHVCLCLKAA GRV" aSDomain complement(19747..19929) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23570_PP-binding.1" /evalue="2.10E-07" /label="EES43_RS23570_PP-binding.1" /locus_tag="EES43_RS23570" /protein_end="86" /protein_start="25" /score="23.1" /tool="antismash" /translation="EQVLEDYGLDDTEITMETRFGRDLELESIDLVTLAGLLEERYGRL VNFAEFVSSMELDEII" aSModule complement(19747..24680) /complete /domains="nrpspksdomains_EES43_RS23575_PKS_KS.1" /domains="nrpspksdomains_EES43_RS23575_PKS_AT.1" /domains="nrpspksdomains_EES43_RS23570_PP-binding.1" /locus_tags="EES43_RS23570" /locus_tags="EES43_RS23575" /monomer_pairings="pk -> pk" /monomer_pairings="pk -> pk" /tool="antismash" /type="pks" gene complement(20001..24719) /locus_tag="EES43_RS23575" /old_locus_tag="EES43_23190" CDS complement(20001..24719) /NRPS_PKS="Domain: PKS_KS(Enediyne-KS) (13-481). E-value: 3.1e-114. Score: 374.1. Matches aSDomain: nrpspksdomains_EES43_RS23575_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (646-862). E-value: 2.5e-37. Score: 120.8. Matches aSDomain: nrpspksdomains_EES43_RS23575_PKS_AT.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_AT" /gene_functions="biosynthetic (rule-based-clusters) T1PKS: PKS_KS" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (smcogs) SMCOG1093: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018890587.1" /locus_tag="EES43_RS23575" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23190" /product="type I polyketide synthase" /protein_id="WP_124270568.1" /sec_met_domain="ketoacyl-synt (E-value: 2.5e-61, bitscore: 205.9, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="PKS_KS (E-value: 3.1e-112, bitscore: 374.1, seeds: 2284, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 2.5e-35, bitscore: 120.8, seeds: 1682, tool: rule-based-clusters)" /transl_table=11 /translation="MSLSAHGGAAHAPVAITGMAVMLPGAPDLATYWHNLGSGVDVIGE APPGRWDRAYYHPGSASEPAAADRVYCRRGGFVDDVAEVDVTRFGIMPNSVPGTEPDQL IALHVAASALADAGGADRLPDRDRVGIVLGRGGYLTPGLARLDQRVRTARQLVRTLGDL MPDLDAERLERIRTAFTDRLGPDRPEDAIGLVPNLAASRVANRLDLRGPAYTVDAACAS SLLAVDQAVTALAAGRCDVMLAGGVHHCHDITLWSVFSQLRALSPSERIRPFHRDADGI LIGEGTGVVVLKRLADAERDGDRVYAVIRGTGVSSDGRTSGLVNPDPAGQTRAVRAAWR AAGLDPAAPGSLGLLEAHGTATPAGDAAELATLREVFGPRRPNGTDPADRPVIGSVKSM IGHAMPAAGVAGLIKAALAVHHATLLPTLHCEDPHPALAATRFRPIDRAAPWVSGPGVP RRAAVNAFGFGGINAHVVLEQAPAAAGRPSPAVTPSAAAARRASVAEGEPVLLLSAATP EALGVLLDDHAQGPGPDAGPGRVTGAGPVRLGIVGPTPKRLALARRVVAKGEAWQGRND VWFSPRPLVGGGAPGRTAFLFPGLEGEFAPHVDDIADHFGLPRPPLAAPGSSSREQGVG DGLGRHGLGVVAVGRLLDTVLRRIGVVPDAVAGHSVGEWTAMAVGGLYEESAVDAFMAG LDPETVRGADLAYAAVGAHAERVTRVLAGGGHPSVVLSHDNAPNQSMVCGPPDAVEAFG AVLRAEGVLVRVLPFRSGFHTPMLEPCLGPFQEAADRMPLRAPHVPVWSGTTAAPFPAD EAAVRALFVRHLLEPVRFRALVEAMYEAGFRAFVQAGPGQLGSLVGDTMAGRDHLVVAA NSPHRSGLAQLRRVAVALWTAGAETDPRVLDAPAPAAAPAYSAPPAPAPTAARRVRLDL GGALVDLPPGLGPVAAPTGDPAAALAPAASASPVAAELSALLRETAQTAATLIAAAGAP RPGGTVRPPRPHRAGFAARTSAPAGPAPTVAASSAAPLPAAPAALLTDVRHETVRVGAD RMPYLLDHCFFPQRADWPDVADRWPVVPATTIVAHLMAAAERAVPGSVAVAVHDACFDR WVTAAEPVDVPVTVAPRGPDQVAVSFGPHARGVVELAARHPRAPAAPEPPDPRSERVPE HTAEQVYRERWMFHGPAYQGMTRLSAIGDRHVRATLTTPPAPGALLDNVGQVLGYWIMA THTERTVVFPVRMRHMRFFGPHPAAGTPVECSIRIVSLTDTVLEAEAVLTVSGRVWAQL TGWQDRRFDNDPHTRPVERFPERNTLSTHRPGGWSLVFERWPDLASRELIMRNALSDPE RTAYAERPPRGRRQWLLGRIAAKDAVRRLLWAEGEGPLFPAELLVGNDAAGRPHVTGRH SREFVPPAVSVAHRAEAGVAIALRRGPDGGEDGFRGPGIDIEEIAEPEEATVTTALSAA EGELLAARQAGGEPRALWFTRFWAAKEAAAKAEGTGFGGRPRDFAVTRAEPDRLTVTVR RPGAPARTYRVSCEQVANPPGLPPRAYIVAWTTGPDPEQPGPGAIHDERDQT" cand_cluster 20246..73981 /SMILES="C([*])C(-O)CC(=O)NC([*])C(=O)NC(CCC(=O)N)C(=O)NC(C (O)C)C(=O)NC(C(C)C)C(=O)O" /candidate_cluster_number="4" /contig_edge="False" /detection_rules="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /kind="single" /product="NRPS" /protoclusters="3" /tool="antismash" protocluster 20246..73981 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="False" /core_location="[40245:53981](+)" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /neighbourhood="20000" /product="NRPS" /protocluster_number="3" /tool="antismash" proto_core 40246..53981 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)" /neighbourhood="20000" /product="NRPS" /protocluster_number="3" aSDomain complement(22134..22781) /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23575_PKS_AT.1" /evalue="2.50E-37" /label="EES43_RS23575_PKS_AT.1" /locus_tag="EES43_RS23575" /protein_end="862" /protein_start="646" /score="120.8" /specificity="substrate consensus: pk" /specificity="PKS signature: (unknown)" /specificity="Minowa: inactive" /tool="antismash" /translation="AVGRLLDTVLRRIGVVPDAVAGHSVGEWTAMAVGGLYEESAVDAF MAGLDPETVRGADLAYAAVGAHAERVTRVLAGGGHPSVVLSHDNAPNQSMVCGPPDAVE AFGAVLRAEGVLVRVLPFRSGFHTPMLEPCLGPFQEAADRMPLRAPHVPVWSGTTAAPF PADEAAVRALFVRHLLEPVRFRALVEAMYEAGFRAFVQAGPGQLGSLVGDTMA" CDS_motif complement(22674..22742) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23575_0002" /evalue="2.00E-09" /label="PKSI-AT-M_m3" /locus_tag="EES43_RS23575" /protein_end="682" /protein_start="659" /score="29.4" /tool="antismash" /translation="GVVPDAVAGHSVGEWTAMAVGGL" aSDomain complement(23277..24680) /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23575_PKS_KS.1" /domain_subtypes="Enediyne-KS" /evalue="3.10E-114" /label="EES43_RS23575_PKS_KS.1" /locus_tag="EES43_RS23575" /protein_end="481" /protein_start="13" /score="374.1" /tool="antismash" /translation="VAITGMAVMLPGAPDLATYWHNLGSGVDVIGEAPPGRWDRAYYHP GSASEPAAADRVYCRRGGFVDDVAEVDVTRFGIMPNSVPGTEPDQLIALHVAASALADA GGADRLPDRDRVGIVLGRGGYLTPGLARLDQRVRTARQLVRTLGDLMPDLDAERLERIR TAFTDRLGPDRPEDAIGLVPNLAASRVANRLDLRGPAYTVDAACASSLLAVDQAVTALA AGRCDVMLAGGVHHCHDITLWSVFSQLRALSPSERIRPFHRDADGILIGEGTGVVVLKR LADAERDGDRVYAVIRGTGVSSDGRTSGLVNPDPAGQTRAVRAAWRAAGLDPAAPGSLG LLEAHGTATPAGDAAELATLREVFGPRRPNGTDPADRPVIGSVKSMIGHAMPAAGVAGL IKAALAVHHATLLPTLHCEDPHPALAATRFRPIDRAAPWVSGPGVPRRAAVNAFGFGGI NAHVVLEQAP" CDS_motif complement(24042..24089) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23575_0001" /evalue="4.10E-05" /label="PKSI-KS_m3" /locus_tag="EES43_RS23575" /protein_end="226" /protein_start="210" /score="15.8" /tool="antismash" /translation="GPAYTVDAACASSLLA" gene complement(24721..31761) /locus_tag="EES43_RS23580" /old_locus_tag="EES43_23195" CDS complement(24721..31761) /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (683-1121). E-value: 1.3e-122. Score: 401.7. Matches aSDomain: nrpspksdomains_EES43_RS23580_PKS_KS.1" /NRPS_PKS="Domain: PKS_AT (1264-1559). E-value: 2.1e-60. Score: 196.5. Matches aSDomain: nrpspksdomains_EES43_RS23580_PKS_AT.1" /NRPS_PKS="Domain: PP-binding (1741-1787). E-value: 1.3e-07. Score: 23.8. Matches aSDomain: nrpspksdomains_EES43_RS23580_PP-binding.1" /NRPS_PKS="Domain: PKS_KR (2068-2291). E-value: 1e-40. Score: 131.5. Matches aSDomain: nrpspksdomains_EES43_RS23580_PKS_KR.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) hglE-KS: hglE" /gene_functions="biosynthetic-additional (rule-based-clusters) ketoacyl-synt" /gene_functions="biosynthetic-additional (rule-based-clusters) PKS_AT" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1022: Beta-ketoacyl synthase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014173579.1" /locus_tag="EES43_RS23580" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23195" /product="type I polyketide synthase" /protein_id="WP_124270569.1" /sec_met_domain="ketoacyl-synt (E-value: 6.8e-68, bitscore: 227.4, seeds: 77, tool: rule-based-clusters)" /sec_met_domain="hglE (E-value: 9.7e-124, bitscore: 411.5, seeds: 4, tool: rule-based-clusters)" /sec_met_domain="PKS_AT (E-value: 2.1e-58, bitscore: 196.5, seeds: 1682, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 6.7e-05, bitscore: 21.8, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTSAENIPDLVIGLTPFGEPDARLAAAVTRGGGLGVLDLGSGDRA ARAAWDDLRRWLPGRHGVRVGPQCRLVLDDLVRDEGLPHTVVLGAGAPWRAGALPRGVR VLAEVTGPDEAHAALDAGVHGLIARGSECGGRIGELGTFVLLQQLLDAVGPDGPPVWAC GGMAPGSAAAAVVGGAAGVVLDTQLALLAESAVPASVAAVLRGMDGSETTVLAGHRFLQ RRAPGATPLEDSPDGERVAALLGGRDPEKRLLPVGQDGFLAARFADRFRDAAGAVRAVT DAVRAAVEGDGAADILRPDSSMSRALGTALPIAQGPMTRVSDGADFARAVADGGALPFL ALALAGRDQAHALLAEAGTALAGRSWGVGVLGFAPEETRTAQLEAVRAHRPTHVIIAGG RPSQARALEDDGIRAFLHVPSPGLLRQYLEQGARRFVFEGAECGGHVGPRNSFPLWEAQ LAVIDAWADQAPDGAAGVEVFLAGGVHDARSAAMVAALAAPLAARGCAVGVLMGTAYLF TEEAVACGAVQPLFQRQVLAAERTALLRTAPGHATRCVPSPFSDGFRDLEAGLRAEGVP GREIWERLERLNVGRLRIASKGVERTAAGGLAAVDESRQYAEGMFMAGEVAVLRSATTT VAELHASVTDGAADFLGRRAAGLLPRLAPGAARTAGGAAKDRAPEPLDVAIVGMACMFP QAPDLASFWAHVLDQYDAVTEVPPERWDPAVHYSAEPGAASASKWGGFLSRIPFDPLRY GIPPTSLGSIEPVQLLALEASRRALEDAGYGEEGRGFDRTRAGVVFGAEAGSDLSNAAT LRAVLPSYYGHVPAALDEQLPRLTEDTFPGMLANVVSGRVANRLDLRGANYTVDAACAS SLAAVDVACKELVMGTSDLMLCGGADLHNGINDYALFTSVHALSPTGRSRAFDDTADGI ALGEGVACVVLKRLADAERDGDRVYGVIKGVGSSSDGRSLGLTAPRPEGQRAALERAYR NAGVSPAQVSLVEAHGTGTVVGDRTELGVLTEVFTEAGASSGACVLGSVKSQIGHTKCA AGLAGLIKTALALYTGVRPPTLHLKRPVSPWKEGESPFVFHREALPWPAAPGQRHAGLS AFGFGGTNFHVVLSAHGGDGPPPVHARDSWPAELFAFRGAGPAAARRAAAELLDLAAAA GSGAAPWRLRDLAATASHRAGRAQGPVQAAFVAHDVAELCVRLRHTLDALDALDAPDPS GATGTAEPGLQAPGAGPAGGPPHGVHLAGPAAEPGLTAFLFPGQGSQRPGMSAHLFTAF PELGRLLGADGDGRAPEALYPPAAFDDAARERARQALTDTRAAQPALGIVELAAYGLLT RSGVRPDLAAGHSYGELVALCAAGVIDPDALPGLSAARARAVLGAAGDDPGAMAAVAAT PEEIERALDGQPPRGLVVANHNAPRQSVVSGPTASVEAALKLLRDAGHGATRLPVACAF HSPLLAEAGPAFRRTLEQQPLRAPEFPVWANRTARPYSPDPDAVRDELAAQIGSPVRFV AQIEAMYEAGARTFVEVGPGRVLTRLVADILGERPHRVVACEPRADSGLPGFLDALARL AAAGVPVVTDWMFQGRDAIDAERTPAPRLPGWTVDGHLVRTASGEPLPGALAPARRVVE TPVTHAGQTPDGAADALIAEFLRTSRDMVSAQRDVLLAYFGAAPAAGPLAGHPAPPYQP ALLPPLPAAPLPAAPAAPPATAPAPVPAAGPVDAPVLTEEGVLRAVLELISERTGYPLD MVEPDLDLEADLSVDSIKRAEIAGELARRLGAAGGSSPASLEDAELEELTRARTASAIA HWMVARALGGSADAPAAAPEPVTAPDGAPEGQADLLVAAPRRFRMLPVALPGPEPEPGP GGLAGKRYALLGDGDGALRGVAAELSARLVSLGAEAALLAADHPLSEADGSVDGVVLLS ALAEEGAPFLPAGFPVVRDALRRGPRRLVLARTAAGVRSAGVDGLMRTAAHEYPDVSVS CVGLDLGADASPAGAAEVLAAELLADAAPPVVLRTSAGRFAPRLTAAPLGALGSTGAGP AGEGAAEAAALGLDRDSVVVVVGGARGITAHCVGVLATASRCRIELLGRTPAPEGPEDP ETAGAGDRAALRAVLAGTGRYGSPAEVARAADLVLARREITATLEALRAAGSRVGYRSV DCREAPAVLQAVKEIHAEHGRIDGVVHAAGIIEDRLMEEKTPASFGQVFGTKTESAAAL LDAVEQLPELPSFALLFGSIAAVLGNRGQADYAAANDALDRLGSAWAARTGRRALTVHW GPWAPAASHTGMVGPELARHYAQRGVTLIDPEEGALALLRELAWGEETVNSVVHTASER " aSDomain complement(24889..25557) /ASF="KR domain putatively catalyzing D-configuration product formation" /ASF="catalytic triad S,Y,N inconclusive" /aSDomain="PKS_KR" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23580_PKS_KR.1" /evalue="1.00E-40" /label="EES43_RS23580_PKS_KR.1" /locus_tag="EES43_RS23580" /protein_end="2291" /protein_start="2068" /score="131.5" /specificity="KR activity: active" /specificity="KR stereochemistry: (unknown)" /tool="antismash" /translation="VVVVVGGARGITAHCVGVLATASRCRIELLGRTPAPEGPEDPETA GAGDRAALRAVLAGTGRYGSPAEVARAADLVLARREITATLEALRAAGSRVGYRSVDCR EAPAVLQAVKEIHAEHGRIDGVVHAAGIIEDRLMEEKTPASFGQVFGTKTESAAALLDA VEQLPELPSFALLFGSIAAVLGNRGQADYAAANDALDRLGSAWAARTGRRALTVHWGPW A" CDS_motif complement(24949..25041) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0006" /evalue="2.60E-13" /label="PKSI-KR_m4" /locus_tag="EES43_RS23580" /protein_end="2271" /protein_start="2240" /score="42.5" /tool="antismash" /translation="FALLFGSIAAVLGNRGQADYAAANDALDRLG" aSDomain complement(26401..26538) /aSDomain="PP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23580_PP-binding.1" /evalue="1.30E-07" /label="EES43_RS23580_PP-binding.1" /locus_tag="EES43_RS23580" /protein_end="1787" /protein_start="1741" /score="23.8" /tool="antismash" /translation="AVLELISERTGYPLDMVEPDLDLEADLSVDSIKRAEIAGELARRL G" aSModule complement(26401..29712) /complete /domains="nrpspksdomains_EES43_RS23580_PKS_KS.1" /domains="nrpspksdomains_EES43_RS23580_PKS_AT.1" /domains="nrpspksdomains_EES43_RS23580_PP-binding.1" /locus_tags="EES43_RS23580" /monomer_pairings="mal -> mal" /tool="antismash" /type="pks" aSDomain complement(27085..27969) /ASF="(Methyl)Malonyl-CoA specificity inconclusive" /ASF="found active site serine: True, scaffold matched GHGE: True" /aSDomain="PKS_AT" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23580_PKS_AT.1" /evalue="2.10E-60" /label="EES43_RS23580_PKS_AT.1" /locus_tag="EES43_RS23580" /protein_end="1559" /protein_start="1264" /score="196.5" /specificity="substrate consensus: mal" /specificity="PKS signature: Malonyl-CoA" /specificity="Minowa: mal" /tool="antismash" /translation="LFPGQGSQRPGMSAHLFTAFPELGRLLGADGDGRAPEALYPPAAF DDAARERARQALTDTRAAQPALGIVELAAYGLLTRSGVRPDLAAGHSYGELVALCAAGV IDPDALPGLSAARARAVLGAAGDDPGAMAAVAATPEEIERALDGQPPRGLVVANHNAPR QSVVSGPTASVEAALKLLRDAGHGATRLPVACAFHSPLLAEAGPAFRRTLEQQPLRAPE FPVWANRTARPYSPDPDAVRDELAAQIGSPVRFVAQIEAMYEAGARTFVEVGPGRVLTR LVADILGERPHRVV" CDS_motif complement(27643..27726) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0005" /evalue="2.20E-09" /label="PKSI-AT-M_m3" /locus_tag="EES43_RS23580" /protein_end="1373" /protein_start="1345" /score="29.2" /tool="antismash" /translation="GVRPDLAAGHSYGELVALCAAGVIDPDA" CDS_motif complement(27922..27972) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0004" /evalue="8.60E-06" /label="PKSI-AT-mM_m1" /locus_tag="EES43_RS23580" /protein_end="1280" /protein_start="1263" /score="18.1" /tool="antismash" /translation="FLFPGQGSQRPGMSAHL" aSDomain complement(28399..29712) /ASF="found active site cysteine: True, scaffold matched GSSS: False" /ASF="found active site histidines: True" /aSDomain="PKS_KS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23580_PKS_KS.1" /domain_subtypes="Trans-AT-KS" /evalue="1.30E-122" /label="EES43_RS23580_PKS_KS.1" /locus_tag="EES43_RS23580" /protein_end="1121" /protein_start="683" /score="401.7" /specificity="transATor: (unknown)" /tool="antismash" /translation="VAIVGMACMFPQAPDLASFWAHVLDQYDAVTEVPPERWDPAVHYS AEPGAASASKWGGFLSRIPFDPLRYGIPPTSLGSIEPVQLLALEASRRALEDAGYGEEG RGFDRTRAGVVFGAEAGSDLSNAATLRAVLPSYYGHVPAALDEQLPRLTEDTFPGMLAN VVSGRVANRLDLRGANYTVDAACASSLAAVDVACKELVMGTSDLMLCGGADLHNGINDY ALFTSVHALSPTGRSRAFDDTADGIALGEGVACVVLKRLADAERDGDRVYGVIKGVGSS SDGRSLGLTAPRPEGQRAALERAYRNAGVSPAQVSLVEAHGTGTVVGDRTELGVLTEVF TEAGASSGACVLGSVKSQIGHTKCAAGLAGLIKTALALYTGVRPPTLHLKRPVSPWKEG ESPFVFHREALPWPAAPGQRHAGLSAFGFGGTNFHVVLS" CDS_motif complement(28612..28656) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0003" /evalue="6.50E-03" /label="PKSI-KS_m6" /locus_tag="EES43_RS23580" /protein_end="1050" /protein_start="1035" /score="9.4" /tool="antismash" /translation="GSVKSQIGHTKCAAG" CDS_motif complement(28717..28761) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0002" /evalue="2.90E-03" /label="PKSI-KS_m5" /locus_tag="EES43_RS23580" /protein_end="1015" /protein_start="1000" /score="10.3" /tool="antismash" /translation="VEAHGTGTVVGDRTE" CDS_motif complement(29137..29184) /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23580_0001" /evalue="8.20E-04" /label="PKSI-KS_m3" /locus_tag="EES43_RS23580" /protein_end="875" /protein_start="859" /score="12.0" /tool="antismash" /translation="GANYTVDAACASSLAA" misc_feature complement(31549..31551) /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" misc_feature complement(31755..31771) /note="TFBS match to ZuR_variant_2, Zinc-responsive repressor, confidence: weak, score: 17.06" /tool="antismash" misc_feature 31755..31771 /note="TFBS match to HexR, Glucose-responsive regulator, confidence: weak, score: 15.15" /tool="antismash" misc_feature complement(31844..31858) /note="TFBS match to IolR, Regulator of the inositol catabolism, confidence: medium, score: 19.39" /tool="antismash" misc_feature complement(32118..32133) /note="TFBS match to ClgR, Caseinolytic protease gene regulator, confidence: weak, score: 20.97" /tool="antismash" misc_feature 32618..32635 /note="TFBS match to ArcA, Repressor of carbon oxidation, confidence: weak, score: 13.95" /tool="antismash" gene 32948..34240 /locus_tag="EES43_RS23585" /old_locus_tag="EES43_23200" CDS 32948..34240 /codon_start=1 /inference="COORDINATES: ab initio prediction:GeneMarkS-2+" /locus_tag="EES43_RS23585" /note="Derived by automated computational analysis using gene prediction method: GeneMarkS-2+." /old_locus_tag="EES43_23200" /product="hypothetical protein" /protein_id="WP_124270570.1" /transl_table=11 /translation="MWSFALADGSVYTKPAGLSGGWRVAPVPDCLDGRITGISADDDEL VAVDGEGRVFTMDHAMNEPRLWNWTSRFGPPIWLGSGTTLPDATVDWSWSVISPAEDVR WTDAIGKPHEIEPAKVSHVYALSGDGSRITYLDPWLPSDHSYELRTPLGGRFQAARLSA SGSTVFVTNRYGDLYTRLYDFDMSGGNSVFFRYSYEDQSGLPTAPNLLLERIDPRYAAV QLPAQDWVRQPKVPGEMTDRISIHKTGPRPDARELRVEGVKDGATGLWRKEIRASAWSF TPTGQPLRGRKLDNTPEDRSTDTLAPPSPHSYAGNGDGYSAEAPGFRTATGATPLNLRF RSGATLKLTLQTVDPLRQFSRADGLDDKPRAYNGAVEVPQELLDNLSQQPPEVRDFVTD TLGARRFTTTGVDASTRSLRIAALGLNLAAR" gene 34564..36447 /locus_tag="EES43_RS23590" /old_locus_tag="EES43_23205" CDS 34564..36447 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010983254.1" /locus_tag="EES43_RS23590" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23205" /product="DUF2075 domain-containing protein" /protein_id="WP_124270571.1" /transl_table=11 /translation="MLFRASAKSVAAAAMDSSLFLHLTEQFFHMHGYRPTASESRSWER SIPALMDVLNEAGLGDVEVMLEYALPLNSKRADAVLAGVHPVTGEPSYVVVELKQWSQA EPEEDDPALCRVDSYTHPVLTPVEQVRRYCEYLVNFNGALAAHPGRINGVAYLHNAAES GVAALRELAFDEHGTLFTAERRGALLDHLRTRLSTEHAGASAADELLRGRPVPSRQLMA VAADEVRDREQFVLLDQQQVAYRMVLNAVSRAKRSDHKEVVIVTGGPGTGKSVIALSLL GELFRRGVPALHATGSQSFTKTMRKVAGARRREVQDLFKYFNSFMTAEKNALDVLICDE AHRIRETSANRYTAAVHRTGKRQMEELIDVARVPVFLLDEHQVVRPGEMGTVAEIEAAA AKKGLACRVVPLDSQFRCGGSGAYLRWVVRLLGLEPGGPVVWDPDDRMRLMVADSPREM EAFLEGRFAQGYGARLSAGYCWPWSKEPKPGDPLVADIVIGDWARPWNLRGERSVSGAP PSALWATDPAGFGQVGCVYTAQGFEYDWSGVIIGPDLIWRGDRWITDRASSEDPVFKKA PSGADVDRLIRNTYKVLLTRGMIGTVVYSTDPETRQKLRELVGATRAIVTV" gene 36595..37251 /locus_tag="EES43_RS23595" /old_locus_tag="EES43_23210" CDS 36595..37251 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010982118.1" /locus_tag="EES43_RS23595" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23210" /product="hypothetical protein" /protein_id="WP_206430110.1" /transl_table=11 /translation="MQLPQDPSNVAHALLAAFPTRLADDVRKVLAVMPEPRIAPMMPFQ VEVQGETFAIPSRIYNEEPGADVEWDPTGTRQVILHCLYSRHHEGHVRQRHLEQLVASG EPWVVPFVVQLAGEYVLEILEAIGRGLPGLAIPGSAQRRLYGEFIARNPAFFARTERRV VSYWSCYYRWKYGTFGTYPGCVLLEAFRAAVVEQVGAEWPRHTPPPLANESGVPA" misc_feature complement(36619..36639) /note="TFBS match to MntR, Manganese transport regulator, confidence: weak, score: 19.32" /tool="antismash" gene 37547..39673 /locus_tag="EES43_RS23600" /old_locus_tag="EES43_23215" CDS 37547..39673 /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004980858.1" /locus_tag="EES43_RS23600" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23215" /product="DUF2075 domain-containing protein" /protein_id="WP_124272129.1" /transl_table=11 /translation="MLLLRLSAKDLLTLDSRRRMVPHLAARWVHFRGEKASLGERTAWA ESLIELARDLVAADRGNVEMIVECSATVDDPERSDRSRQIDVVLAGRHPADGDISVQLV ELKRWSTVTRVEKATADLVHIPGIDDVKRHPALQLREYYELFTGATGPLHGLRFECGGF TYLHNATDESVRPLLGIDAPTGSYARTYTKDSRNKLQEDLRQHFTADEHPSAAEILLSR MNLRNTPLLDAMIKSNGEDTVFTLRGRQKRVADDVLEAAVHVLDDPAADALVQNPRRAV FLVTGGAGTGKSAIGLQLKAEFEAAGRTVMYASGSRAFNGAMQEHVGYGDREFKESFTY FSNFVTPPEEPLDVLICDEAHRLRERSFNRFWASEKQGTKAQIDELLDASRLTVFLLDE SQSLRPNEVGTVDVIKDAAGRRGVVARSYHLQEQYRCGGSDAYIRWVRDLLGLSGGRPG LWTPDGLMHIEVVDTPDELEDILRTEFDSGASARMVAGFCWPWSPPDEARKLVADVRIG DWHRPWNASSESFCAGGEPPSKIWSVHDAGFGQIGCIYTAQGLEWDWCGVIMGDDMVWR TDKWVFRRGKKRKDKDTGTQHVIEPGSLDTEVCRKTGTDDEAFARCIRNAYHVLLTRAS RATVLYSSDKETRDYLRSLVGDIEIHGLRPTWESLPPEARVPHQARPARGSRSRNARRK KAKQLKEKDELKLF" gene complement(39724..39852) /locus_tag="EES43_RS31510" /old_locus_tag="EES43_23220" CDS complement(39724..39852) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016431608.1" /locus_tag="EES43_RS31510" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23220" /product="DUF6408 family protein" /protein_id="WP_241192512.1" /transl_table=11 /translation="MNPVEYTSARRIWFRKVLMDVAVGVVANLVVAAVAAAAHLLF" gene 40246..46605 /locus_tag="EES43_RS23605" /old_locus_tag="EES43_23225" CDS 40246..46605 /NRPS_PKS="Domain: Condensation_LCL (15-299). E-value: 1.2e-82. Score: 269.3. Matches aSDomain: nrpspksdomains_EES43_RS23605_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (470-860). E-value: 1.3e-102. Score: 335.4. Matches aSDomain: nrpspksdomains_EES43_RS23605_AMP-binding.1" /NRPS_PKS="Domain: PCP (977-1045). E-value: 2.9e-26. Score: 83.4. Matches aSDomain: nrpspksdomains_EES43_RS23605_PCP.1" /NRPS_PKS="Domain: Condensation_LCL (1061-1362). E-value: 1.7e-105. Score: 344.3. Matches aSDomain: nrpspksdomains_EES43_RS23605_Condensation_LCL.2" /NRPS_PKS="Domain: AMP-binding (1535-1926). E-value: 2.6e-93. Score: 304.8. Matches aSDomain: nrpspksdomains_EES43_RS23605_AMP-binding.2" /NRPS_PKS="Domain: PCP (2029-2097). E-value: 2.5e-26. Score: 83.6. Matches aSDomain: nrpspksdomains_EES43_RS23605_PCP.2" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1209: polyketide synthase associated protein papA3" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827425.1" /locus_tag="EES43_RS23605" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23225" /product="non-ribosomal peptide synthetase" /protein_id="WP_124270572.1" /sec_met_domain="AMP-binding (E-value: 3.4e-112, bitscore: 373.5, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 2e-73, bitscore: 245.5, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 3.8e-15, bitscore: 54.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTAGAAPEGARNGGDTLTASFAQRRLWFLDQLAGTSAGSMLPLVL RITGPLDEARLARALDGIVARHEVLRTRFAAVGGEPVPVVDPPGGIALERVEAEGPADL FARCLGRPVDLSVQHPVRAALARVAPDEHLLLVEVHHIAVDGWSWGVLLEELAAGYRGE SPAPPATRYADLAEAQTARLSGARMERLLAYWRERLAGLAPLDLPGDRPRPRVWDGSGD VVRFTLPADLVAGVDSLARGHRATRYMLLLTVYQALLGHWTGRTDVAVCSTMADRAGAG AANVVGPLVNTVVLRTDLSGGPGFGELLERVRTRVLQDLSHAEAPFERVVGAVGGERDL SRHPLAQASFTLLNSALKPVRMPGLDVELVPPPLAETHLDVFLDLTLRTDGGIAAILQY ATALFDPATMRAFADAYTALLRAVVADPRTPVRDLLRALPATAARTPALPRAEWSRSPD VPAVPDRPLGFRGEPGATALICGDDSVTYAGLDGMTGGLARALVDAGAGPGSPVGVLLR RGLWSVAAIEGVWRAGGAYVPLDPELPAERLRFMAQEAGLACVVADAATAEDAAALAPV TVRVDMVAPSAHGPRHLPDPRELAHVIFTSGSTGRPKAVGVEHAALASHVAAFRHRLGI TADDRVLAFASFSFDASLDQVLPALTSGATVVVRPDEPWLPTRVPEVVRQHGLTVVNVP PTYWSELTLSLGRREASALASLRLLVLGGEAVPADTLAAWHAAVPGVRVCNAYGPTETT VTATTHETDGPPGGTVPIGRPLGGRRVHVVDPDGEPVPVGVSGELLIGGTEVARGYLRR PALTAERFTPDPAGPPGSRLYRTGDLVRWTPAGELEFLGRRDDQVKIRGFRIELGEVES VLRACPDVAAAAVRPDRATGRTLVGYVVPAAPAGEAGQDTGAGVERVALRAWCARQLPH YAVPSEFVVLDALPVGVGGKLDRSALPDPAHARSGSATGYVAPRDDTERTVADIWADVL GLERIGIDDSFFDLGGHSLLATMAVSRVAQHLGRDIELRTVFENPTVRTFAPRVAAARP SAGADAVVPADRTKPLPLSFAQERLWFLDRTSDRGDAYLLHYGWRLRGGLDRTAWQHAL DDLVERHEVLRTALVESDGRPVQRVRDAVPVPLHWERAPDGPSERERLDAVRERAAALA TRRFDLTRTPLLRAGVWELAEDDHVAVVALHHAVTDGWSKGVLVDELAQHYRARREGRR AVLPPLEVQYADYAVWQRDRADSGALEPQLAYWEETLDGAAALELPTDRSRPAAFSGRG GAVEVELPAGLADRVDAFARERGATRFMVLLAAAQLVLSRWSGQSDVCVGTPVAGRGRV ELEPLVGFFVNTVVLRTDLSGRPGFARLLDRVRDGVLGAFDHQEVPFERVVERLRPPRD LSRNPLFQVMVDVQDSPAAGPAVPGLRADGFALPWGSAKFDLTATFLVAPGRFALNVEY AADLFDPGTATRFARHVGRVLRAVLDEPGRPVDEAAMTSAEEYAHLLATAGSATAGSAT GESAPAPGTAPRFAVSGRPADTAVVCEGEAVDHAGLDALTGGLARLLADSGAAPRDAVG VCLGRGVRSVAAMLAVWRAGGVYVPLDPRLPAERLRFMLAEAGVRYVVTDAASHDLVSG LGAVTVPVERAAPDPDGPRHTPAPGDLAYVIFTSGSTGLPKAVGVEHHALDAHAATARE QFALTRDDRVLTFASTSFDASLEQILPALGAGAAVVVRPDDIWSVDELAARVAAEGVTV MELTPSYWEEVVARLDTLAPRLAGLRLLVTGGEALPADPLERWFAHLPGVPVLNTYGPT EAVVSATAHRVERAPDGHRVPIGRPLGGRRAYVVDARDALVPEGVPGELLLGGPELARG YLGRPALTAERFVPDPFGPPGGRLYRTGDVVRRLPSGETEFLGRNDTQAKIRGFRVEPG EAEAVLRRHPGVRAAAVTVRTLHGDPALVAYAAGDALQADALEAHCRAHLPHYLVPSAF VLLDALPLTVQGKLDTAALPAPDAPAPVAFVGPRTPAESVVAQIWAEVLDLPRVGVHDD FFALGGHSLRAVSVASRLRTAFDCPVQVRDLFEHPTVALLAADVERRLLALISEMSDDE IALSLTADL" aSDomain 40291..41142 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="1.20E-82" /label="EES43_RS23605_Condensation_LCL.1" /locus_tag="EES43_RS23605" /protein_end="299" /protein_start="15" /score="269.3" /specificity="C activity: active" /specificity="Active site motif: HHIAVDG" /tool="antismash" /translation="TLTASFAQRRLWFLDQLAGTSAGSMLPLVLRITGPLDEARLARAL DGIVARHEVLRTRFAAVGGEPVPVVDPPGGIALERVEAEGPADLFARCLGRPVDLSVQH PVRAALARVAPDEHLLLVEVHHIAVDGWSWGVLLEELAAGYRGESPAPPATRYADLAEA QTARLSGARMERLLAYWRERLAGLAPLDLPGDRPRPRVWDGSGDVVRFTLPADLVAGVD SLARGHRATRYMLLLTVYQALLGHWTGRTDVAVCSTMADRAGAGAANVVGPLVNTVVLR TDL" aSModule 40291..43380 /complete /domains="nrpspksdomains_EES43_RS23605_Condensation_LCL.1" /domains="nrpspksdomains_EES43_RS23605_AMP-binding.1" /domains="nrpspksdomains_EES43_RS23605_PCP.1" /locus_tags="EES43_RS23605" /monomer_pairings="X -> X" /tool="antismash" /type="nrps" CDS_motif 40303..40335 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0001" /evalue="8.00E-03" /label="C1_LCL_004-017" /locus_tag="EES43_RS23605" /protein_end="30" /protein_start="19" /score="9.0" /tool="antismash" /translation="SFAQRRLWFLD" CDS_motif 40366..40470 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0002" /evalue="3.20E-16" /label="C2_LCL_024-062" /locus_tag="EES43_RS23605" /protein_end="75" /protein_start="40" /score="51.7" /tool="antismash" /translation="LPLVLRITGPLDEARLARALDGIVARHEVLRTRFA" CDS_motif 40660..40725 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0003" /evalue="1.40E-10" /label="C3_LCL_132-143" /locus_tag="EES43_RS23605" /protein_end="160" /protein_start="138" /score="33.6" /tool="antismash" /translation="VHHIAVDGWSWGVLLEELAAGY" CDS_motif 40981..41034 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0004" /evalue="1.70E-01" /label="Cy4" /locus_tag="EES43_RS23605" /protein_end="263" /protein_start="245" /score="5.2" /tool="antismash" /translation="TRYMLLLTVYQALLGHWT" CDS_motif 41044..41133 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0005" /evalue="4.50E-07" /label="C5_LCL_267-296" /locus_tag="EES43_RS23605" /protein_end="296" /protein_start="266" /score="22.4" /tool="antismash" /translation="DVAVCSTMADRAGAGAANVVGPLVNTVVLR" CDS_motif 41182..41301 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0006" /evalue="1.20E-12" /label="C67_LCL_14fromHMM" /locus_tag="EES43_RS23605" /protein_end="352" /protein_start="312" /score="40.1" /tool="antismash" /translation="RTRVLQDLSHAEAPFERVVGAVGGERDLSRHPLAQASFTL" aSDomain 41656..42825 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_AMP-binding.1" /evalue="1.30E-102" /label="EES43_RS23605_AMP-binding.1" /locus_tag="EES43_RS23605" /protein_end="860" /protein_start="470" /score="335.4" /specificity="substrate consensus: X" /tool="antismash" /translation="GEPGATALICGDDSVTYAGLDGMTGGLARALVDAGAGPGSPVGVL LRRGLWSVAAIEGVWRAGGAYVPLDPELPAERLRFMAQEAGLACVVADAATAEDAAALA PVTVRVDMVAPSAHGPRHLPDPRELAHVIFTSGSTGRPKAVGVEHAALASHVAAFRHRL GITADDRVLAFASFSFDASLDQVLPALTSGATVVVRPDEPWLPTRVPEVVRQHGLTVVN VPPTYWSELTLSLGRREASALASLRLLVLGGEAVPADTLAAWHAAVPGVRVCNAYGPTE TTVTATTHETDGPPGGTVPIGRPLGGRRVHVVDPDGEPVPVGVSGELLIGGTEVARGYL RRPALTAERFTPDPAGPPGSRLYRTGDLVRWTPAGELEFLGRRDDQVKIR" CDS_motif 41827..41865 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0007" /evalue="1.30E-04" /label="NRPS-A_a2" /locus_tag="EES43_RS23605" /protein_end="540" /protein_start="527" /score="15.3" /tool="antismash" /translation="GVWRAGGAYVPLD" CDS_motif 42043..42102 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0008" /evalue="1.30E-07" /label="NRPS-A_a3" /locus_tag="EES43_RS23605" /protein_end="619" /protein_start="599" /score="24.0" /tool="antismash" /translation="AHVIFTSGSTGRPKAVGVEH" CDS_motif 42484..42510 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0009" /evalue="2.50E-02" /label="NRPS-A_a5" /locus_tag="EES43_RS23605" /protein_end="755" /protein_start="746" /score="7.6" /tool="antismash" /translation="YGPTETTVT" CDS_motif 42616..42705 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0010" /evalue="1.40E-14" /label="NRPS-A_a6" /locus_tag="EES43_RS23605" /protein_end="820" /protein_start="790" /score="46.1" /tool="antismash" /translation="PVGVSGELLIGGTEVARGYLRRPALTAERF" CDS_motif 42790..42855 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0011" /evalue="2.30E-12" /label="NRPS-A_a8" /locus_tag="EES43_RS23605" /protein_end="870" /protein_start="848" /score="38.7" /tool="antismash" /translation="FLGRRDDQVKIRGFRIELGEVE" aSDomain 43177..43380 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_PCP.1" /evalue="2.90E-26" /label="EES43_RS23605_PCP.1" /locus_tag="EES43_RS23605" /protein_end="1045" /protein_start="977" /score="83.4" /tool="antismash" /translation="ERTVADIWADVLGLERIGIDDSFFDLGGHSLLATMAVSRVAQHLG RDIELRTVFENPTVRTFAPRVAA" aSDomain 43429..44331 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_Condensation_LCL.2 " /domain_subtypes="Condensation_LCL" /evalue="1.70E-105" /label="EES43_RS23605_Condensation_LCL.2" /locus_tag="EES43_RS23605" /protein_end="1362" /protein_start="1061" /score="344.3" /specificity="C activity: active" /specificity="Active site motif: HHAVTDG" /tool="antismash" /translation="KPLPLSFAQERLWFLDRTSDRGDAYLLHYGWRLRGGLDRTAWQHA LDDLVERHEVLRTALVESDGRPVQRVRDAVPVPLHWERAPDGPSERERLDAVRERAAAL ATRRFDLTRTPLLRAGVWELAEDDHVAVVALHHAVTDGWSKGVLVDELAQHYRARREGR RAVLPPLEVQYADYAVWQRDRADSGALEPQLAYWEETLDGAAALELPTDRSRPAAFSGR GGAVEVELPAGLADRVDAFARERGATRFMVLLAAAQLVLSRWSGQSDVCVGTPVAGRGR VELEPLVGFFVNTVVLRTDL" aSModule 43429..46536 /complete /domains="nrpspksdomains_EES43_RS23605_Condensation_LCL.2" /domains="nrpspksdomains_EES43_RS23605_AMP-binding.2" /domains="nrpspksdomains_EES43_RS23605_PCP.2" /locus_tags="EES43_RS23605" /monomer_pairings="Gln -> Gln" /tool="antismash" /type="nrps" CDS_motif 43444..43476 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0012" /evalue="6.90E-03" /label="C1_LCL_004-017" /locus_tag="EES43_RS23605" /protein_end="1077" /protein_start="1066" /score="9.2" /tool="antismash" /translation="SFAQERLWFLD" CDS_motif 43495..43605 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0013" /evalue="8.90E-14" /label="C2_LCL_024-062" /locus_tag="EES43_RS23605" /protein_end="1120" /protein_start="1083" /score="43.8" /tool="antismash" /translation="DAYLLHYGWRLRGGLDRTAWQHALDDLVERHEVLRTA" CDS_motif 43831..43896 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0014" /evalue="4.60E-09" /label="C3_LCL_132-143" /locus_tag="EES43_RS23605" /protein_end="1217" /protein_start="1195" /score="28.8" /tool="antismash" /translation="LHHAVTDGWSKGVLVDELAQHY" CDS_motif 43945..43980 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0015" /evalue="6.80E-05" /label="C4_LCL_164-176" /locus_tag="EES43_RS23605" /protein_end="1245" /protein_start="1233" /score="15.5" /tool="antismash" /translation="QYADYAVWQRDR" CDS_motif 44170..44223 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0016" /evalue="1.90E-02" /label="Cy4" /locus_tag="EES43_RS23605" /protein_end="1326" /protein_start="1308" /score="8.2" /tool="antismash" /translation="TRFMVLLAAAQLVLSRWS" CDS_motif 44233..44322 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0017" /evalue="1.10E-16" /label="C5_LCL_267-296" /locus_tag="EES43_RS23605" /protein_end="1359" /protein_start="1329" /score="53.1" /tool="antismash" /translation="DVCVGTPVAGRGRVELEPLVGFFVNTVVLR" CDS_motif 44371..44487 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0018" /evalue="1.40E-22" /label="C67_LCL_14fromHMM" /locus_tag="EES43_RS23605" /protein_end="1414" /protein_start="1375" /score="72.2" /tool="antismash" /translation="RDGVLGAFDHQEVPFERVVERLRPPRDLSRNPLFQVMVD" aSDomain 44851..46023 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_AMP-binding.2" /evalue="2.60E-93" /label="EES43_RS23605_AMP-binding.2" /locus_tag="EES43_RS23605" /protein_end="1926" /protein_start="1535" /score="304.8" /specificity="substrate consensus: Gln" /tool="antismash" /translation="SGRPADTAVVCEGEAVDHAGLDALTGGLARLLADSGAAPRDAVGV CLGRGVRSVAAMLAVWRAGGVYVPLDPRLPAERLRFMLAEAGVRYVVTDAASHDLVSGL GAVTVPVERAAPDPDGPRHTPAPGDLAYVIFTSGSTGLPKAVGVEHHALDAHAATAREQ FALTRDDRVLTFASTSFDASLEQILPALGAGAAVVVRPDDIWSVDELAARVAAEGVTVM ELTPSYWEEVVARLDTLAPRLAGLRLLVTGGEALPADPLERWFAHLPGVPVLNTYGPTE AVVSATAHRVERAPDGHRVPIGRPLGGRRAYVVDARDALVPEGVPGELLLGGPELARGY LGRPALTAERFVPDPFGPPGGRLYRTGDVVRRLPSGETEFLGRNDTQAKIR" CDS_motif 45022..45063 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0019" /evalue="4.30E-05" /label="NRPS-A_a2" /locus_tag="EES43_RS23605" /protein_end="1606" /protein_start="1592" /score="16.7" /tool="antismash" /translation="LAVWRAGGVYVPLD" CDS_motif 45241..45300 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0020" /evalue="2.40E-08" /label="NRPS-A_a3" /locus_tag="EES43_RS23605" /protein_end="1685" /protein_start="1665" /score="26.2" /tool="antismash" /translation="AYVIFTSGSTGLPKAVGVEH" CDS_motif 45679..45705 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0021" /evalue="2.40E-01" /label="NRPS-A_a5" /locus_tag="EES43_RS23605" /protein_end="1820" /protein_start="1811" /score="4.8" /tool="antismash" /translation="YGPTEAVVS" CDS_motif 45814..45903 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0022" /evalue="8.20E-15" /label="NRPS-A_a6" /locus_tag="EES43_RS23605" /protein_end="1886" /protein_start="1856" /score="46.9" /tool="antismash" /translation="PEGVPGELLLGGPELARGYLGRPALTAERF" CDS_motif 45988..46053 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23605_0023" /evalue="1.20E-09" /label="NRPS-A_a8" /locus_tag="EES43_RS23605" /protein_end="1936" /protein_start="1914" /score="30.3" /tool="antismash" /translation="FLGRNDTQAKIRGFRVEPGEAE" aSDomain 46333..46536 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23605_PCP.2" /evalue="2.50E-26" /label="EES43_RS23605_PCP.2" /locus_tag="EES43_RS23605" /protein_end="2097" /protein_start="2029" /score="83.6" /tool="antismash" /translation="ESVVAQIWAEVLDLPRVGVHDDFFALGGHSLRAVSVASRLRTAFD CPVQVRDLFEHPTVALLAADVER" gene 46668..53981 /locus_tag="EES43_RS23610" /old_locus_tag="EES43_23230" CDS 46668..53981 /NRPS_PKS="Domain: Condensation_LCL (56-352). E-value: 7.3e-103. Score: 335.6. Matches aSDomain: nrpspksdomains_EES43_RS23610_Condensation_LCL.1" /NRPS_PKS="Domain: AMP-binding (521-929). E-value: 2.1e-106. Score: 347.9. Matches aSDomain: nrpspksdomains_EES43_RS23610_AMP-binding.1" /NRPS_PKS="Domain: PCP (1037-1104). E-value: 5.2e-23. Score: 73.0. Matches aSDomain: nrpspksdomains_EES43_RS23610_PCP.1" /NRPS_PKS="Domain: Condensation_DCL (1130-1432). E-value: 2.1e-54. Score: 176.6. Matches aSDomain: nrpspksdomains_EES43_RS23610_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (1586-1976). E-value: 2.7e-96. Score: 314.6. Matches aSDomain: nrpspksdomains_EES43_RS23610_AMP-binding.2" /NRPS_PKS="Domain: PCP (2086-2154). E-value: 1.4e-21. Score: 68.5. Matches aSDomain: nrpspksdomains_EES43_RS23610_PCP.2" /NRPS_PKS="Domain: Thioesterase (2175-2423). E-value: 1.7e-27. Score: 89.3. Matches aSDomain: nrpspksdomains_EES43_RS23610_Thioesterase.1" /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) Thioesterase" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827426.1" /locus_tag="EES43_RS23610" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23230" /product="non-ribosomal peptide synthetase" /protein_id="WP_124270573.1" /sec_met_domain="Condensation (E-value: 2e-70, bitscore: 235.7, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 4.1e-117, bitscore: 389.7, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 2.5e-11, bitscore: 42.3, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Thioesterase (E-value: 3.1e-23, bitscore: 81.6, seeds: 16, tool: rule-based-clusters)" /transl_table=11 /translation="MTTSDVRPGPLAPNGDQPPARGDGGLSPAARRLLQQRLSGVAAAT ADGPVRAAERPERLPLSAAQRRLYFLDRLDPGAATYLLPAAWRLAGPLDVPALRAAVAG LTARHEQLRVVFPEHDGTPHQRVLPAGDDVLDVVDLTGPADGDREALLAAAVRSAATRP FDLARRPAFRATLVRAADDDHVLVLAMHHIVSDGWSLGLLVRDLGELYAARTAGRVADL PELPLDYTDYALWQDRADHTAELAHWRTRLEGLTPLELPADHPRPDAPGGDGAAHTLTL PAALADELAELGRRTGATAYMIVLAAFQAALAFRSGQDDIAVGTVVANRERPEIEQLVG FFVNTLVLRADLSDDPTPAAFLARTRESALDAFSHQTLPFEQVVDALSPERDLARNPLV QVLFTHSSAEPGGLALGGVHGVPYRIDLTTAKFDLALELRDGHGPAELVFVYRSDLYDA ASVSSLAQHTVTFLEAFCRTPDTPLGSIDPLTAEERAGLLGPDGPANAGPPAAPAPRTA PERLAEHIARTPHAAAVSGSGRTLTYAELDAAASALARRMRAAGVAPGSLVGVCLERSP DLAVALLAVWRTGAGYLPLDPAHPHARRAFTVADAGIDWIVADAASRAAAEALPAGVIP LEADDDALRARDEAGAGGDLRPAPDDLAYVIYTSGSTGRPKGVEITHANLAWLLDAADR HFDFGPSDVWTQVHSPAFDFSVWELWTPLTSGGRVVVLDADQVRDPAAVHRVLREEGVT VLNQTPAAFKGLRAQVAGGEAGFADLPLRTVVFGGDAFDVRDYRDWFAAPGPKPDLVNM YGITETTVHVTFGRVTEDDVRGTVRSPIGRPLTGQHGYVLDARGRLVPPGSTGELYVSG GGVARGYRNRPELTAERFLDDPFGAPGGRMYRTGDLVRVERDGRLGYVGRADHQVKIRG YRIEPGEIETVLRALSGVADAAVVARPERDGARLVAHVVTTEGRPLDAPALREGLRLQL PDHMVPALFVRHPRLPLTANGKVDRAALTAITPAAAARGGHVPPEGPVESVLAGVWAQV LGAEHVGRTDNFFDLGGDSILALRVVGLARQGGLALTIADVFRARTLADLAGAATEARE APEPVAPFTQLDPADADRLPEGLEDAYPLTMLQAGMLHEMLADPLHGAYHNVTDLKITV PEGFDRAAFQAAVDAAVAGHGILRTSVDLVSYREPLQLVHRGAHLPVGYTDLRGLPRED QRARLRRFVDEEFDHRFDLSAAPLVRIHLHHVTDTELRLVLTDCHVVLDGWSLTSLVAD LLELHRQAVAHRTAPRPPSAPAFAEYVALERAALHSEPSLDYWRGRLADLRPVSFARRA DADAGQQPLYEVRRSYADLAEPIGRLAREAGVPRRTVLIAAFHHTMSLFAQRDDSALGH SIGLVTNGRPEVPDADRMRGLFLNTVPFGVARPRGSWIDYLRDVFATEQEMLPHRRVPL VRIAQLRPTEPGLVDAVFNYVNFHRLTHDTWDDSLEIARTLFPLLVNASVNGFTLDADP DRVPPATAEQLADVLCAQLAAMVADPQARVTRPALTGPARTTVLEDWARGPELPSSPLL FHEHIAVHAARTPNAVAVEGCGETLTYGELVEQADELAQTLRGLGVGPETVVGICAERG CDLVRAAVGVLRSGGAFLPLDAQHPTERLEFMVRDSGMRVLLTQRPLAGTVPFDGPVLH LDAEPDAPLPAPAAAPTTGPVEADADTVAYIIYTSGSTGTPKGVAIPHRGLSNMLEGQR DLVGPLATDRVLQFASFGFDASVLELTWALANGGRLVTAPRQALRPGPDLAETLRGGRV TGAMLPPSALAVLGEDAFPDLRVLQVAGEACPAELADVWARGRRFQNVYGLTETTVWSV AADLSPGRGRPPIGSPIRNTRVHVLDDDLQPVPVGVPGEIHLGGRAVGRGYLGRPALTA AAYVPDPYGAPGERLCRTGDLGALRPDGTVEWLGRRDSQVKLRGFRIELGEIEHALRRL PEVRQAVVLHRTDLPGEPALVAYLVTDGSPGAEPRELRLALRSSLPGYMVPARFVVLDA MPVNTSGKIDKRALPLPPADRAESDIAYVAPATPAEKTLAEVWREVLGLSRIGVDDDFF RIGGSSLSTVRVSLMAAARGLTVSVGDLIEHPTIARLADHVTRTATAELPAAVTSRVRL RDGEGAPLWCVHPTGGSAAWFVPLARALPPGRPVHAFQARGLLGGVDPSTVAGIAANYV GEMAEGEGQGPHELLGWSMGANIALEMATQLHEGGHRVAPLVLIEPYLPNPAARARLTG VARELREALRMRDRLRSLPPSPRRDTAAAELTAALLGAGMSPTEASLVEDAPIEVWHSL LAALAAYEVRPYPGHVHLVVGSEAAGLPAGRTMPGLDVDYATYVERWRAVAGDGLTLHV SDGDHMSVLAGPRAANIARLLDSVATAPEEGR" aSDomain 46836..47723 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_Condensation_LCL.1 " /domain_subtypes="Condensation_LCL" /evalue="7.30E-103" /label="EES43_RS23610_Condensation_LCL.1" /locus_tag="EES43_RS23610" /protein_end="352" /protein_start="56" /score="335.6" /specificity="C activity: active" /specificity="Active site motif: HHIVSDG" /tool="antismash" /translation="ERLPLSAAQRRLYFLDRLDPGAATYLLPAAWRLAGPLDVPALRAA VAGLTARHEQLRVVFPEHDGTPHQRVLPAGDDVLDVVDLTGPADGDREALLAAAVRSAA TRPFDLARRPAFRATLVRAADDDHVLVLAMHHIVSDGWSLGLLVRDLGELYAARTAGRV ADLPELPLDYTDYALWQDRADHTAELAHWRTRLEGLTPLELPADHPRPDAPGGDGAAHT LTLPAALADELAELGRRTGATAYMIVLAAFQAALAFRSGQDDIAVGTVVANRERPEIEQ LVGFFVNTLVLRADL" aSModule 46836..49979 /complete /domains="nrpspksdomains_EES43_RS23610_Condensation_LCL.1" /domains="nrpspksdomains_EES43_RS23610_AMP-binding.1" /domains="nrpspksdomains_EES43_RS23610_PCP.1" /locus_tags="EES43_RS23610" /monomer_pairings="Thr -> Thr" /tool="antismash" /type="nrps" CDS_motif 46902..47018 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0001" /evalue="3.10E-14" /label="C2_LCL_024-062" /locus_tag="EES43_RS23610" /protein_end="117" /protein_start="78" /score="45.3" /tool="antismash" /translation="ATYLLPAAWRLAGPLDVPALRAAVAGLTARHEQLRVVFP" CDS_motif 47235..47300 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0002" /evalue="1.20E-11" /label="C3_LCL_132-143" /locus_tag="EES43_RS23610" /protein_end="211" /protein_start="189" /score="36.9" /tool="antismash" /translation="MHHIVSDGWSLGLLVRDLGELY" CDS_motif 47352..47381 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0003" /evalue="1.50E-02" /label="C4_LCL_164-176" /locus_tag="EES43_RS23610" /protein_end="238" /protein_start="228" /score="8.2" /tool="antismash" /translation="YTDYALWQDR" CDS_motif 47625..47714 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0004" /evalue="6.40E-17" /label="C5_LCL_267-296" /locus_tag="EES43_RS23610" /protein_end="349" /protein_start="319" /score="53.8" /tool="antismash" /translation="DIAVGTVVANRERPEIEQLVGFFVNTLVLR" CDS_motif 47763..47882 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0005" /evalue="1.40E-20" /label="C67_LCL_14fromHMM" /locus_tag="EES43_RS23610" /protein_end="405" /protein_start="365" /score="65.7" /tool="antismash" /translation="RESALDAFSHQTLPFEQVVDALSPERDLARNPLVQVLFTH" aSDomain 48231..49454 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_AMP-binding.1" /evalue="2.10E-106" /label="EES43_RS23610_AMP-binding.1" /locus_tag="EES43_RS23610" /protein_end="929" /protein_start="521" /score="347.9" /specificity="substrate consensus: Thr" /tool="antismash" /translation="AEHIARTPHAAAVSGSGRTLTYAELDAAASALARRMRAAGVAPGS LVGVCLERSPDLAVALLAVWRTGAGYLPLDPAHPHARRAFTVADAGIDWIVADAASRAA AEALPAGVIPLEADDDALRARDEAGAGGDLRPAPDDLAYVIYTSGSTGRPKGVEITHAN LAWLLDAADRHFDFGPSDVWTQVHSPAFDFSVWELWTPLTSGGRVVVLDADQVRDPAAV HRVLREEGVTVLNQTPAAFKGLRAQVAGGEAGFADLPLRTVVFGGDAFDVRDYRDWFAA PGPKPDLVNMYGITETTVHVTFGRVTEDDVRGTVRSPIGRPLTGQHGYVLDARGRLVPP GSTGELYVSGGGVARGYRNRPELTAERFLDDPFGAPGGRMYRTGDLVRVERDGRLGYVG RADHQVKIR" CDS_motif 48414..48455 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0006" /evalue="1.40E-03" /label="NRPS-A_a2" /locus_tag="EES43_RS23610" /protein_end="596" /protein_start="582" /score="12.2" /tool="antismash" /translation="LAVWRTGAGYLPLD" CDS_motif 48654..48713 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0007" /evalue="5.60E-10" /label="NRPS-A_a3" /locus_tag="EES43_RS23610" /protein_end="682" /protein_start="662" /score="31.1" /tool="antismash" /translation="AYVIYTSGSTGRPKGVEITH" CDS_motif 49245..49334 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0008" /evalue="1.80E-16" /label="NRPS-A_a6" /locus_tag="EES43_RS23610" /protein_end="889" /protein_start="859" /score="52.2" /tool="antismash" /translation="PPGSTGELYVSGGGVARGYRNRPELTAERF" CDS_motif 49419..49484 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0009" /evalue="1.40E-12" /label="NRPS-A_a8" /locus_tag="EES43_RS23610" /protein_end="939" /protein_start="917" /score="39.4" /tool="antismash" /translation="YVGRADHQVKIRGYRIEPGEIE" aSDomain 49779..49979 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_PCP.1" /evalue="5.20E-23" /label="EES43_RS23610_PCP.1" /locus_tag="EES43_RS23610" /protein_end="1104" /protein_start="1037" /score="73.0" /tool="antismash" /translation="ESVLAGVWAQVLGAEHVGRTDNFFDLGGDSILALRVVGLARQGGL ALTIADVFRARTLADLAGAATE" cand_cluster 50038..84826 /candidate_cluster_number="5" /contig_edge="False" /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))" /detection_rules="cds(LANC_like and DUF4135)" /kind="chemical_hybrid" /product="lanthipeptide-class-i" /product="lanthipeptide-class-ii" /protoclusters="4" /protoclusters="5" /tool="antismash" protocluster 50038..84826 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[60037:74826]" /cutoff="10000" /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="4" /tool="antismash" proto_core 60038..74826 /aStool="rule-based-clusters" /tool="antismash" /cutoff="10000" /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))" /neighbourhood="10000" /product="lanthipeptide-class-i" /protocluster_number="4" protocluster 50038..73145 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="False" /core_location="[60037:63145](-)" /cutoff="20000" /detection_rule="cds(LANC_like and DUF4135)" /neighbourhood="10000" /product="lanthipeptide-class-ii" /protocluster_number="5" /tool="antismash" proto_core complement(60038..63145) /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(LANC_like and DUF4135)" /neighbourhood="10000" /product="lanthipeptide-class-ii" /protocluster_number="5" aSDomain 50058..50963 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_Condensation_DCL.1 " /domain_subtypes="Condensation_DCL" /evalue="2.10E-54" /label="EES43_RS23610_Condensation_DCL.1" /locus_tag="EES43_RS23610" /protein_end="1432" /protein_start="1130" /score="176.6" /specificity="C activity: active" /specificity="Active site motif: CHVVLDG" /tool="antismash" /translation="EDAYPLTMLQAGMLHEMLADPLHGAYHNVTDLKITVPEGFDRAAF QAAVDAAVAGHGILRTSVDLVSYREPLQLVHRGAHLPVGYTDLRGLPREDQRARLRRFV DEEFDHRFDLSAAPLVRIHLHHVTDTELRLVLTDCHVVLDGWSLTSLVADLLELHRQAV AHRTAPRPPSAPAFAEYVALERAALHSEPSLDYWRGRLADLRPVSFARRADADAGQQPL YEVRRSYADLAEPIGRLAREAGVPRRTVLIAAFHHTMSLFAQRDDSALGHSIGLVTNGR PEVPDADRMRGLFLNTVPFGV" aSModule 50058..53936 /complete /domains="nrpspksdomains_EES43_RS23610_Condensation_DCL.1" /domains="nrpspksdomains_EES43_RS23610_AMP-binding.2" /domains="nrpspksdomains_EES43_RS23610_PCP.2" /domains="nrpspksdomains_EES43_RS23610_Thioesterase.1" /final_module /locus_tags="EES43_RS23610" /monomer_pairings="Val -> Val" /tool="antismash" /type="nrps" CDS_motif 50175..50243 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0010" /evalue="5.80E-05" /label="C2_LCL_024-062" /locus_tag="EES43_RS23610" /protein_end="1192" /protein_start="1169" /score="15.5" /tool="antismash" /translation="FDRAAFQAAVDAAVAGHGILRTS" CDS_motif 50475..50531 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0011" /evalue="6.70E-05" /label="C3_DCL_135-156" /locus_tag="EES43_RS23610" /protein_end="1288" /protein_start="1269" /score="15.5" /tool="antismash" /translation="HVVLDGWSLTSLVADLLEL" CDS_motif 50877..50957 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0012" /evalue="2.20E-07" /label="C5_DCL_263-294" /locus_tag="EES43_RS23610" /protein_end="1430" /protein_start="1403" /score="23.4" /tool="antismash" /translation="IGLVTNGRPEVPDADRMRGLFLNTVPF" aSDomain 51426..52595 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_AMP-binding.2" /evalue="2.70E-96" /label="EES43_RS23610_AMP-binding.2" /locus_tag="EES43_RS23610" /protein_end="1976" /protein_start="1586" /score="314.6" /specificity="substrate consensus: Val" /tool="antismash" /translation="HAARTPNAVAVEGCGETLTYGELVEQADELAQTLRGLGVGPETVV GICAERGCDLVRAAVGVLRSGGAFLPLDAQHPTERLEFMVRDSGMRVLLTQRPLAGTVP FDGPVLHLDAEPDAPLPAPAAAPTTGPVEADADTVAYIIYTSGSTGTPKGVAIPHRGLS NMLEGQRDLVGPLATDRVLQFASFGFDASVLELTWALANGGRLVTAPRQALRPGPDLAE TLRGGRVTGAMLPPSALAVLGEDAFPDLRVLQVAGEACPAELADVWARGRRFQNVYGLT ETTVWSVAADLSPGRGRPPIGSPIRNTRVHVLDDDLQPVPVGVPGEIHLGGRAVGRGYL GRPALTAAAYVPDPYGAPGERLCRTGDLGALRPDGTVEWLGRRDSQVKLR" CDS_motif 51606..51644 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0013" /evalue="4.70E-03" /label="NRPS-A_a2" /locus_tag="EES43_RS23610" /protein_end="1659" /protein_start="1646" /score="10.6" /tool="antismash" /translation="GVLRSGGAFLPLD" CDS_motif 51843..51902 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0014" /evalue="4.90E-10" /label="NRPS-A_a3" /locus_tag="EES43_RS23610" /protein_end="1745" /protein_start="1725" /score="31.3" /tool="antismash" /translation="AYIIYTSGSTGTPKGVAIPH" CDS_motif 52386..52472 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0015" /evalue="1.60E-12" /label="NRPS-A_a6" /locus_tag="EES43_RS23610" /protein_end="1935" /protein_start="1906" /score="39.6" /tool="antismash" /translation="PVGVPGEIHLGGRAVGRGYLGRPALTAAA" CDS_motif 52560..52625 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0016" /evalue="3.50E-11" /label="NRPS-A_a8" /locus_tag="EES43_RS23610" /protein_end="1986" /protein_start="1964" /score="35.1" /tool="antismash" /translation="WLGRRDSQVKLRGFRIELGEIE" aSDomain 52926..53129 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_PCP.2" /evalue="1.40E-21" /label="EES43_RS23610_PCP.2" /locus_tag="EES43_RS23610" /protein_end="2154" /protein_start="2086" /score="68.5" /tool="antismash" /translation="EKTLAEVWREVLGLSRIGVDDDFFRIGGSSLSTVRVSLMAAARGL TVSVGDLIEHPTIARLADHVTRT" aSDomain 53193..53936 /ASF="active site serine inconclusive" /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23610_Thioesterase.1" /evalue="1.70E-27" /label="EES43_RS23610_Thioesterase.1" /locus_tag="EES43_RS23610" /protein_end="2423" /protein_start="2175" /score="89.3" /tool="antismash" /translation="PLWCVHPTGGSAAWFVPLARALPPGRPVHAFQARGLLGGVDPSTV AGIAANYVGEMAEGEGQGPHELLGWSMGANIALEMATQLHEGGHRVAPLVLIEPYLPNP AARARLTGVARELREALRMRDRLRSLPPSPRRDTAAAELTAALLGAGMSPTEASLVEDA PIEVWHSLLAALAAYEVRPYPGHVHLVVGSEAAGLPAGRTMPGLDVDYATYVERWRAVA GDGLTLHVSDGDHMSVLAGPRAANIA" CDS_motif 53376..53444 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23610_0017" /evalue="1.40E-09" /label="NRPS-te1" /locus_tag="EES43_RS23610" /protein_end="2259" /protein_start="2236" /score="30.3" /tool="antismash" /translation="QGPHELLGWSMGANIALEMATQL" gene 53978..55216 /locus_tag="EES43_RS23615" /old_locus_tag="EES43_23235" CDS 53978..55216 /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1007: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004991550.1" /locus_tag="EES43_RS23615" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23235" /product="cytochrome P450" /protein_id="WP_124270574.1" /sec_met_domain="p450 (E-value: 3.6e-19, bitscore: 67.3, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MTTAPVLAPAFTERYLLSADLNADPYGYLDSLREHAPVHWSPMHH AWLVTGYDQVMRCLRHPAVSADRVRPLMDAVPQGAREDAERAFSVLSRWMVFNDPPQHR RLRQVFQEQFAARSVARYRTFSERATAALLARRSRPGEDGDLMADIAKPLPALVFARWL GVPQKDAPSFWYWNARVADLVLGTAQEESEYRASLQALVSLEDYLAGLVAERRAAPADD LISSVLGGGRVGRTVTEEEFTGLLTQMAFAGGETTSNLIANTVLALLERPDQLEAVRAD PTLVPGAVEETLRLDGPSKMSIRTAARDLDLDGHTVRAGERIFLVTAAANRDPERFAEP GRFDVRRTGATHLGFGFGAHFCIGAALARLVAVAVVGTVVRDYPALALRDPDGHAWQPS LLNRSLTALPVSY" gene 55310..56581 /locus_tag="EES43_RS23620" /old_locus_tag="EES43_23240" CDS 55310..56581 /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /GO_process="GO:0055085 - transmembrane transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1020: major facilitator transporter" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827427.1" /locus_tag="EES43_RS23620" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23240" /product="MFS transporter" /protein_id="WP_124270575.1" /transl_table=11 /translation="MATTLEDRAGPRLWTPARHRSFRLLWAGQSLSLLGDGFSVVAFSW ITLSLTGSTLTLGYVLAFQAVPRALLTLVGGSLTGTWSARTLMVASSWTRAALMAAVGL AGLSGDLTVWALCLAAAAFGTVDAFFQPARVSILPSVVEKDLLTPANALLGAGSRVAAV AGPAVGGVVIAMSDAPVAFLVDAVCFALCGLFVARVRTLPRPPAPPAAPADGAEAGKPA ATSLGARIREGVVYTWRDPRLRTIVVFDTAVNFCYAGPFTVGFATLADQVLRGGSATLG VLNGSLAGGAMLGTLAGGLMGGRPRVGLLIAGLAGWLAAGMALLGLVHSTPAVVLTVLA MGFAIGFQGVFGVSWIQRNIPEDVLSRVISVDMVLGYAAAPLSLIVCGALARTGTFAMF GGVALVLAVTGLAVLASRPVRAMR" gene complement(56652..59576) /locus_tag="EES43_RS31760" /old_locus_tag="EES43_23245" CDS complement(56652..59576) /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827428.1" /locus_tag="EES43_RS31760" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23245" /product="LuxR family transcriptional regulator" /protein_id="WP_124270576.1" /transl_table=11 /translation="MSSHALSLIGRDSQLFLLERALSDARRGQGGVVFLIGEAGVGKSR LAAEAVGTALAAGTRVLRGRSSTTGPAVPFRPLTEALLALFRSGQALDDLELGPYRPVL GRLIPDWDTGERDSSSMVILGEAVLRLLIASDRGQGQLLLLEDLHDADPETLGVLEYLV DNLENTPILLLATVRTDFSDALDLAQSARRRGVAGLVELPPLSREQTHGLIAAQLGTDA GRVPAPILERLWEDSAGSPYLVEELLQSMIGAGTLVQGSEGWRVVGDPRSDVPSTLARG ILRRIDRLGAEGLTLLSAAAVLGRRFPLTVLQRMTGVDDRSLLSHLHAGVAARLVIPDE PAPDWYSFRHSLTVEALFTQLTPGQRADLARRGAEAVRELHPDLPGEWCAQAAGLHAEA GDRSAAGRLFAEAGRRALAAGALGSAVTLLSRAESLLAPGADPQGRAEALEHLLPALAE SGDFARAFELAEHLHALDIAGLSPSRLAVLHTRLAKVAHTAGRWSDGNRQIARARQVLG AAPDEAASAAVDVTAAYLALDTPGADRTQHAEKLARSAADAAERHQLPAVACQAWELLA TVARERDPEESRAMLDQALATAEHHRLPLQRMYAATRKGGNAWLARGDTGELLAAREEA LRLGSVSIMHTVDGILVLDAVLRGSYDRAREAAAECLAVVRRLRLAPAVRYVLMARAAL EAHRGDRAAMEAAVASFAEWDGAGSQEEPLTLGMARAFCALMEEDRELARAELRAVTAL EEGNPSTYHLSGTHGIGLLLDVLAGDADRARHEEVSATAVGRMRWNRQFVLLADAVLLG REGRGARAAAAVEEALGEAEPYPAALHLGLRLISDAAHADGWGDPVAWLRRAEHHFHEQ DVLPVVNACRAALRRLGAPVHQHRTGTSGIPEELRALGVTVREFEVFGLLAERLGNKDI ADRLFISPRTAEKHIASLITKTGAANRADLCARSAAARRPGRGV" gene complement(59712..59927) /locus_tag="EES43_RS23630" /old_locus_tag="EES43_23250" CDS complement(59712..59927) /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827430.1" /locus_tag="EES43_RS23630" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23250" /product="hypothetical protein" /protein_id="WP_124270577.1" /transl_table=11 /translation="MDQNLTGTPSATAAALDGPAAPATGHDAAGGIALSGRNRACARVR VLAGMVLTSGIVITLTSLDTSVSSPQ" gene complement(60038..63145) /locus_tag="EES43_RS23635" /old_locus_tag="EES43_23255" CDS complement(60038..63145) /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: LANC_like" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: LANC_like" /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-ii: DUF4135" /gene_functions="biosynthetic-additional (smcogs) SMCOG1070: lanthionine synthetase C family protein" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014670273.1" /locus_tag="EES43_RS23635" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23255" /product="type 2 lantipeptide synthetase LanM family protein" /protein_id="WP_241192513.1" /sec_met_domain="DUF4135 (E-value: 4.2e-94, bitscore: 314.2, seeds: 79, tool: rule-based-clusters)" /sec_met_domain="LANC_like (E-value: 1.7e-11, bitscore: 42.0, seeds: 47, tool: rule-based-clusters)" /transl_table=11 /translation="MTDSASLRNPRSPRLPNAWWAPALSLAERVAAPGEPVAATAPARR TPWAAGDTEGFAARLAYLGIGADGLAALADEPAERLAGRAGVPDWARYVEEALASVGPR PARAPACGGEDTEVFVPVVAALAAPAAARLAERLAPLPEAERNVVGASFELWLGRRLAR LAARTLVRELDAARRAGRLDGRGPGERFASFVTATGGRAGLCALFTAYPVLARMLGRTA LDAADAVGEWGLRFHADRAELTASLFAGRDPGPLTRIELGRGDAHQGGRSVAVLGFADG SRAVYKPRSLEHHALLDDLAGWLNGAVSGLDLRTPRTVRRETYGWLEFIEHRWCGSVTE ADAFYRRQGALLALLYAVDGADMHYENVIACADQPVLVDAETLLHTGLPQATTAGADPA ADALHASVHRTCLLPHLLIGEHGALDISALGRADDGTHPSEGLRWEDTGLDTMRAVRGP VTSPGAENQPLPGGRSLTGADHRAALLEGFRTAYAAIAARGGELLAPDGPLETRGSAPA RIVVRATRLYATLLEESAHPSLLGDALARDAVFAVLWTESRHDPARQRLIEHETADLWR GDVPLFTHRPAGTEVGTADGTWLPDLLPVASLRAVRAKIGRMDGVDCHDQEWIVAATLA ALGADSPLDGPRSELVPAPVPAVASSPSRLLAAACGIADEIAARALSAGGRSNWLCLER FPSDHWAVLPMGAGLAQGYCGVALFLAEAGALAGAERYTTLAREAVRPLPALLKALAAD AEPCAAVGPGAYDGIGGILYTLVRLSRVLDPELRDCLPDALTALGHAVASCSDLSLAGG AAGALASAVAVHEATGDAGALRLADAVADALLRAPVPEGGPAGFAGGAAGIGWALLRYA ALRPERAGHAGAGRALLGPALAAASAAPDDLSWSTGLAGVLAAAADLPGGRARAASLTG RSAALASGADLSLGHGALGALETLTLLAGAGDPAASDALALRTGQALGTVEAQGHRCAT PDRVPSPGLLTGLSGIGYGLLRLAHPDRVPSALLLQHPRDRTPTDS" gene 63743..64354 /locus_tag="EES43_RS23640" /old_locus_tag="EES43_23260" CDS 63743..64354 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family DNA-binding response regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015580244.1" /locus_tag="EES43_RS23640" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23260" /product="response regulator transcription factor" /protein_id="WP_124270579.1" /transl_table=11 /translation="MAEIVSVSVVALDPVLEAGTRSALTACPDLLLARPEEARVAVLTV DRLDEAELDMLRTTRATPNRPAVVLVAGAFAPGDVLHALAAGARGLLPRREAATPRLSQ AVLAAARDDCTLPPDLLDQVLDTSGAARHGSGAGAGNGLSERERSVLRMVADGHETAEI AQRLAYSPRTVTTVVHDITHRFRLRNRAHAVAYALRAGLL" misc_feature 63749..63760 /note="TFBS match to CcpA, Catabolite control protein A, confidence: weak, score: 15.18" /tool="antismash" gene 64351..64995 /locus_tag="EES43_RS31525" /old_locus_tag="EES43_23265" CDS 64351..64995 /GO_function="GO:0003677 - DNA binding [Evidence IEA]" /GO_process="GO:0000160 - phosphorelay signal transduction system [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1197: autoinducer-binding transcriptional regulator," /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_018487437.1" /locus_tag="EES43_RS31525" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23265" /product="response regulator transcription factor" /protein_id="WP_241192514.1" /transl_table=11 /translation="MTATATALAAPLAATPQPLVHLVRSRGAERVHDLARRAGLTCTLG PADAARPAAEPRTVTIVVAEDAEEALRDARDAGPCVVVCDTVTRAGVRMALRAGAAVLR TADLTAENLAKAVRSAGNRQPGIPYPVLSHLLAAGPPRGRPAPDVSTLPLTARQTTVLR LMADGHGNADISRMLSCSEHTVKNVIYEVMARLQARNRAHAVAHAVRSGLI" gene complement(65053..65793) /locus_tag="EES43_RS23650" /old_locus_tag="EES43_23270" CDS complement(65053..65793) /EC_number="3.4.13.21" /GO_function="GO:0008233 - peptidase activity [Evidence IEA]" /GO_function="GO:0008236 - serine-type peptidase activity [Evidence IEA]" /GO_function="GO:0016805 - dipeptidase activity [Evidence IEA]" /GO_process="GO:0006508 - proteolysis [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004991562.1" /locus_tag="EES43_RS23650" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23270" /product="peptidase E" /protein_id="WP_124270580.1" /transl_table=11 /translation="MTAPQPTIVATSGGHRVGARARVLFDSLVHHAVDLSGVHGRRPRV LYLGTAVGDAEHVTARMHEAARYAGFDLTPLALFPMPNVEDVEATLLAHDVVWVMGGSV ANLLAVWRVHGLEGALRRAWRAGVVLSGVSAGSICWFQGGATDSYGPRLRPVTDALGFL PYGNGVHYDSDGGRRPLIHRLVADGTLPTTHCTDDGVGLVYRGTELVEAVTEIPGKGAY VVTREGDRAVEERVEPRRLPPPPD" gene complement(65917..66723) /locus_tag="EES43_RS23655" /old_locus_tag="EES43_23275" CDS complement(65917..66723) /GO_function="GO:0000287 - magnesium ion binding [Evidence IEA]" /GO_function="GO:0008897 - holo-[acyl-carrier-protein] synthase activity [Evidence IEA]" /NRPS_PKS="Domain: ACPS (167-226). E-value: 1.8e-07. Score: 22.9. Matches aSDomain: nrpspksdomains_EES43_RS23655_ACPS.1" /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1012: 4'-phosphopantetheinyl transferase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015031690.1" /locus_tag="EES43_RS23655" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23275" /product="4'-phosphopantetheinyl transferase superfamily protein" /protein_id="WP_124270581.1" /transl_table=11 /translation="MSEPGTGPDLLVAAHAPPAAARAAPVGYAPPGPLRPAPLDPALLW RRPDPVAPRPLSGPLELYLAHARPRDERLLLRAREILDAEERARAGAFRRDADRDVYVV AHTALRSVLGDLLGVRPDALPLMREPCAGCGGPHGRPALRGSGIHFSLSHSGDLVMMAL ARAPVGVDVERLAGVQAVLGAQSALHVAEVRELARLPEGERQAAFTRAWVRKEAYLKGL GTGLVRSPGLDYVGTGPVPAVPSPGWELRDVRVPAGYAAAVALRTP" aSDomain complement(66046..66222) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23655_ACPS.1" /evalue="1.80E-07" /label="EES43_RS23655_ACPS.1" /locus_tag="EES43_RS23655" /protein_end="226" /protein_start="167" /score="22.9" /tool="antismash" /translation="VGVDVERLAGVQAVLGAQSALHVAEVRELARLPEGERQAAFTRAW VRKEAYLKGLGTGL" gene complement(66716..66949) /locus_tag="EES43_RS23660" /old_locus_tag="EES43_23280" CDS complement(66716..66949) /codon_start=1 /gene_functions="biosynthetic-additional (smcogs) SMCOG1009: mbtH-like protein" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_009064956.1" /locus_tag="EES43_RS23660" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23280" /product="MbtH family NRPS accessory protein" /protein_id="WP_124272131.1" /transl_table=11 /translation="MTGTEAERAPAEAREEFLVVRNDEEQYSIWRADRDLPAGWYADGC RGARQECLDHIEEVWTDMRPLSLRRRLAGADV" gene 67225..69564 /locus_tag="EES43_RS23665" /old_locus_tag="EES43_23285" CDS 67225..69564 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_N" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015580239.1" /locus_tag="EES43_RS23665" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23285" /product="lantibiotic dehydratase" /protein_id="WP_124270582.1" /sec_met_domain="Lant_dehydr_N (E-value: 5.6e-46, bitscore: 155.3, seeds: 73, tool: rule-based-clusters)" /transl_table=11 /translation="MSDDHGNVLLPGGGWRLWEQFALRGPGFPADGVLHLAPAGLADAA DKFGPGSDLAGPEWDAFAEDVSRGAVRTAHQLQEIAALPRFQAALAWQNPAVLRTGIAP FLRWDPSTGRSSMPRQREELVAHYWQRFCVKNDTIGFFGPVGWGRWDLSTRGVESDPGD GFLAGSQVYFAGWAVDALVKVLAGDPELMRWIPPHRVSFVRVADGAVRVPGRPAQPIGA LAAAVLERCDGTRPVAAIAADLGIGADEAADTVRELASRRWVRWRLDVPADTHPDRALR RILERVPEGAARERALEQLSVLERGRDAVQAAGADAVALTAAIGALEADFAALTDTEAQ RTKGERTAPCRGLVYSDARRAATATVGSALLAELAPLELCLTAARWMTNRFAQGVRARL RTVHDRLRADGEAVDLGTMWLHTLPSPHPEAGDLIDAVQAEMRDRWTRVLDLPADARRV RLSSADLAEGVRAAFDEPGDGWSLARYVSPDVLVVAEDEQALESGDVDLVLGEMHCALN TMGASLFVHQHPDRDELLAETTRDFPGPRLLPMLAKELPLKWSSRSRPSLDRPQDHYVA LVDQTGDPHRPRTYASADVAVEDRDGRLHAVLPDGTAYDLLDAYANTLTQRVMDRFTLR PSGDHTPRITVDRMVVARETWNLPVADIDFAEEKSEAVRFVRARHWRDRHELPRFVFVV SPTEPRPFYVDFDSPVYLTILAKAIRRLARKDPAARLRVSEMLPTPEQAWLTDHEGSAY TSELRFVAVDRTVTDPAATGPATGEA" gene 69564..71123 /locus_tag="EES43_RS23670" /old_locus_tag="EES43_23290" CDS 69564..71123 /NRPS_PKS="Domain: AMP-binding (9-408). E-value: 1.2e-80. Score: 263.0. Matches aSDomain: nrpspksdomains_EES43_RS23670_AMP-binding.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) AMP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1002: AMP-dependent synthetase and ligase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_016827438.1" /locus_tag="EES43_RS23670" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23290" /product="amino acid adenylation domain-containing protein" /protein_id="WP_124270583.1" /sec_met_domain="AMP-binding (E-value: 5.5e-87, bitscore: 290.5, seeds: 400, tool: rule-based-clusters)" /transl_table=11 /translation="MRTVVDDILAHAERDPGRTALTTPDGDTSYAELAARVTALSRTLA ARGAGPETVCAVAAERGTDAVAAMAAVLGRGAAFLSLDTGQPRERLASFVRSGRAGLLL TTSALAARLDLPVPGPPVLLDRPVRQDPADRRPGPPAPVDPRSLAYVSHTSGSTGEPSA VLIEHRGLDAYLRDAAAVFGLGPATVALQIAPLGYDASIRDTFVPLLAGGRVVIVDRGA LLRPEEFTATVRRYGVNTLLSVTPSFLSHLAGARTGRDPLAGVTLVASSGESLRPFLTA GGRSLVPGALVNQYGPTECTMTTTRHSVPADPDPAADVVGRPGAGAVVRLLDADLAPVP DGTPGEVCIGGVGVGRGYSGRPARTAECFVPDPLGPPGARLYRTGDLARQSSEGLHYAG RRDRQVKIRGYRVDPAEVEGALLAHPAVTGAVVTSPTDADGRVHLVAHLTGDLSGTPDA ALRGHLVRLLPPHLMPRRFVRLDELPTTRGGKADRRTLAALGPAPARPAPDAVRPPLGT GR" aSDomain 69591..70787 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23670_AMP-binding.1" /evalue="1.20E-80" /label="EES43_RS23670_AMP-binding.1" /locus_tag="EES43_RS23670" /protein_end="408" /protein_start="9" /score="263.0" /specificity="substrate consensus: X" /tool="antismash" /translation="AHAERDPGRTALTTPDGDTSYAELAARVTALSRTLAARGAGPETV CAVAAERGTDAVAAMAAVLGRGAAFLSLDTGQPRERLASFVRSGRAGLLLTTSALAARL DLPVPGPPVLLDRPVRQDPADRRPGPPAPVDPRSLAYVSHTSGSTGEPSAVLIEHRGLD AYLRDAAAVFGLGPATVALQIAPLGYDASIRDTFVPLLAGGRVVIVDRGALLRPEEFTA TVRRYGVNTLLSVTPSFLSHLAGARTGRDPLAGVTLVASSGESLRPFLTAGGRSLVPGA LVNQYGPTECTMTTTRHSVPADPDPAADVVGRPGAGAVVRLLDADLAPVPDGTPGEVCI GGVGVGRGYSGRPARTAECFVPDPLGPPGARLYRTGDLARQSSEGLHYAGRRDRQVKIR " CDS_motif 70008..70067 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23670_0001" /evalue="5.80E-07" /label="NRPS-A_a3" /locus_tag="EES43_RS23670" /protein_end="168" /protein_start="148" /score="22.0" /tool="antismash" /translation="AYVSHTSGSTGEPSAVLIEH" CDS_motif 70443..70475 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23670_0002" /evalue="1.60E-03" /label="NRPS-A_a5" /locus_tag="EES43_RS23670" /protein_end="304" /protein_start="293" /score="11.0" /tool="antismash" /translation="QYGPTECTMTT" CDS_motif 70581..70670 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23670_0003" /evalue="6.50E-14" /label="NRPS-A_a6" /locus_tag="EES43_RS23670" /protein_end="369" /protein_start="339" /score="44.0" /tool="antismash" /translation="PDGTPGEVCIGGVGVGRGYSGRPARTAECF" CDS_motif 70752..70817 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_EES43_RS23670_0004" /evalue="7.10E-11" /label="NRPS-A_a8" /locus_tag="EES43_RS23670" /protein_end="418" /protein_start="396" /score="34.1" /tool="antismash" /translation="YAGRRDRQVKIRGYRVDPAEVE" gene 71120..72094 /locus_tag="EES43_RS23675" /old_locus_tag="EES43_23295" CDS 71120..72094 /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PALP" /gene_functions="biosynthetic-additional (smcogs) SMCOG1081: cysteine synthase" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014152233.1" /locus_tag="EES43_RS23675" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23295" /product="pyridoxal-phosphate dependent enzyme" /protein_id="WP_124270584.1" /sec_met_domain="PALP (E-value: 1.5e-69, bitscore: 233.1, seeds: 145, tool: rule-based-clusters)" /transl_table=11 /translation="MKAAALRPGPADLAAAADRIARHVVRTPLLAGPSARPGGPRILLK AEHLQNGGSFKTRGAANAVLALDAVRLVTGSSGNHGIALARLASSLGLRLTVVLAAGAV PAKAAAIRALGARTVHVSGGVAERDERARELAGRGDALLVPSSDHPLVIAGQGTVGAEV LADAPDTETLYVPTGGGGLLAGVCLAARHHPVRVVGVEPATTPRYARSLAAGRPLRLPP GSTVADGLRGQCPGTFTYPIVSDRVDDMIAVDDAEILAAAELLRRHGAEAEPSGAVALA GALRARRRERAVAVVSGGNTAARLHTLALTHALTGALTKEKTS" gene 72091..72363 /locus_tag="EES43_RS23680" /old_locus_tag="EES43_23300" CDS 72091..72363 /NRPS_PKS="Domain: ACP (18-85). E-value: 6e-20. Score: 63.3. Matches aSDomain: nrpspksdomains_EES43_RS23680_ACP.1" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_kind="biosynthetic-additional" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004991569.1" /locus_tag="EES43_RS23680" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23300" /product="acyl carrier protein" /protein_id="WP_124270585.1" /sec_met_domain="PP-binding (E-value: 2.7e-17, bitscore: 61.5, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MTPNTATATAATTATGTLDLLVGIFRDVLGLADLTADCDFYEAGG DSLTAFQITGRLQEALGAEIPVSLVFAYPTPADLAEVLDADYGRA" aSDomain 72145..72345 /ASF="found active site serine: True" /ASF="non-beta-branching ACP" /aSDomain="ACP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_EES43_RS23680_ACP.1" /evalue="6.00E-20" /label="EES43_RS23680_ACP.1" /locus_tag="EES43_RS23680" /protein_end="85" /protein_start="18" /score="63.3" /tool="antismash" /translation="DLLVGIFRDVLGLADLTADCDFYEAGGDSLTAFQITGRLQEALGA EIPVSLVFAYPTPADLAEVLDA" gene 72538..74826 /locus_tag="EES43_RS23685" /old_locus_tag="EES43_23310" CDS 72538..74826 /codon_start=1 /gene_functions="biosynthetic (rule-based-clusters) lanthipeptide-class-i: Lant_dehydr_N" /gene_kind="biosynthetic" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_004921201.1" /locus_tag="EES43_RS23685" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23310" /product="lantibiotic dehydratase" /protein_id="WP_124270586.1" /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-36, bitscore: 123.7, seeds: 73, tool: rule-based-clusters)" /transl_table=11 /translation="MTDDLVPSLGRWRLWEQFALRGPGFPADGVLRLAPPGLARAADKF APGDALDGPLWQDFAQVFAGASVETALTLQDIARTPAFREAVAWQNRPVLTSGIAPFLR WTPTAASRSSMPRQREELVAHYWQRFCVKNDTIGFFGPVGWGRWDGRADGVETDTGSGL TAATTVYWAGWAVDALARTLAADPALREWTAPRRIPFVGLDGRTVTVPGRRPVTVPADT AAVLARCDGVRPARRIAAELPDVDVTAVLEDLVARRWAVWRLEIPADTHPDRALRAWLE SVDADEPRRRGLAALDRLEEGRARVAAARGADALVAAMTALEEDFVDLTETPAVREKSA STAPCRALVYADTRRAATVRLGSAVHDALAPLRPLLDSAGWITSRLAETVEREALRVHA ALAAEGPVDLASFWFGCLPVLHGPARAAADGVQADFRARWQEILAVPADARDVRLRLAD IAEPVRRHFGTRGGGWTAARYMSPDVMIAADGADAVARGDFTLVLGELHLAANTLGASL FVHQHSDPAELVRLTDRDHPAPRLLPLIPKEHRARLSARIRNSLVRPGDHQVALADFTA DPARSRAVRSADALVELRDGALVVLLPDGSAYPAMDVFAHVLTTLAMDLFQILPESDHS PRVTVDRLVVARETWRFTAARAAFADEKDEARRFVGARRWRAEHGLPRFVFAVSPTESR PFYVDFDSPVYVTILAKALRRLARKDPEGRITFTEMLPTPEQTWLSDDEGRRYTSELRF VAYDEEAGS" misc_feature complement(74943..74956) /note="TFBS match to LexA_variant_2, Repressor of DNA damage response, confidence: weak, score: 17.48" /tool="antismash" gene 74984..78142 /locus_tag="EES43_RS31765" /old_locus_tag="EES43_23315" CDS 74984..78142 /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1041: transcriptional regulator, SARP family" /gene_kind="regulatory" /inference="COORDINATES: protein motif:HMM:NF013124.4" /locus_tag="EES43_RS31765" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23315" /product="BTAD domain-containing putative transcriptional regulator" /protein_id="WP_124270587.1" /transl_table=11 /translation="MRGEVGAGWRARLLGPVELWTGAESVLVTGRQGALLAGLLLSGNR VVSVDRLAESVWGEPLPRSPAARVRMLVSELRRTCAAAGSDLIRTQRPGYVLPLEAGQL DLTRFQDGVALAREAAAAGDPAAAVARFDEALGLWRGAPLEGAAGRFVPAEAARLEELR IGAVEERAEAMLALGRHVEVISELGPVVAGHPLREPAHSRLMLALYRGGRRAEALDVYR RLRERVVDELGLEPERELQRLHQRILTADTALDRPGPPPGGAPHAPYAARAPQAARPAA RAAPAAPATSAAPDEPDEPDEPEVPDEPEVPDQPEVPAEAQGPEVPVEPDGTPAGPGAS VSAADAREDTRTGALAAPVPRQLPAPPPLFVGRDHERAELDRVARDREPGGVAIAAISG VGGMGKTWLALQWAHDNLAHCPDGQLYVNLRGFDPANRPLPARAALRHFLGSLGVHPAV IPTEEEAQAGLYRSLVADRRLLVVLDDARDLAQIEPLLPGGSGCTVVITSRNRLAGLHT AHGARLIELGALSSAESRGLLTRRLGRARVEADPASVAALVEHSGGLPLATGVLAARAA LHPDFPLSVLADELRSPATRLDALRAGDLHTDLRAAFASSYQALDAAAARLFALSGLVP WPGLTPHTAAALAGVPVSRARLLLNHLESAHLVHQHRQGQYRTHDLVHLYAAERARGDL TAQDRHEALTRLVDALAGTACAGDRLLSPHRPLSTRMSPTTGPGEDPDAGEEFADAAAA WAWFEAEQPNLVAAQELAARLDRETAVLRLAWAMDPFHIRRCQHDLRIFLWRTALASAD RSGRRSTRAFAHWYLGYAYAQAGRTGDGVEHLELALSLFEQDGDRAGQAHTSHTLGYAW AVRGEPGRAIVHAENALRLQRALGDPVWEGNALSAVGWCHAKLARYEQARSSCERALEL FRRHADANGESAALDSLGYIAHRTGRYPQALEYYHRCLALRERLGNTYQGADTLVRVGD VQHEMGRPAAARDVWERALDLYRRQHRPAEAEGVREKIRSAARTSAAAVPTGCAAAADR RSPA" misc_feature 75086..75088 /note="tta leucine codon, possible target for bldA regulation" /tool="antismash" gene complement(78063..79358) /locus_tag="EES43_RS23695" /old_locus_tag="EES43_23320" CDS complement(78063..79358) /GO_function="GO:0004497 - monooxygenase activity [Evidence IEA]" /GO_function="GO:0005506 - iron ion binding [Evidence IEA]" /GO_function="GO:0016705 - oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Evidence IEA]" /GO_function="GO:0020037 - heme binding [Evidence IEA]" /codon_start=1 /gene_functions="biosynthetic-additional (rule-based-clusters) p450" /gene_functions="biosynthetic-additional (smcogs) SMCOG1034: cytochrome P450" /gene_kind="biosynthetic-additional" /inference="COORDINATES: protein motif:HMM:NF012296.4" /locus_tag="EES43_RS23695" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23320" /product="cytochrome P450" /protein_id="WP_124270588.1" /sec_met_domain="p450 (E-value: 5.4e-53, bitscore: 178.8, seeds: 50, tool: rule-based-clusters)" /transl_table=11 /translation="MKRASGPDRPPGPRGHWLFGNSEDYDRDRSGFLERCHREFGDVFS FDARTVVVSSPDQVHALLTRTNEDFLAENSPLAGPVDTERMADDAKLWTTTRRAGWQGL HRRVAQAHAERLHEIFLDTVGDGELDVLATMTDFFGRATADFCLGPDAAGVPEALAENV AAIDPLSRNSLQFPAWWPSRKVRRFTASRERLLALMTDLVRRRRSAGESPVQDLLGVLL APRDQELSDLQIERFLRGIMLAALGVPATALAWIVYELGERPDVLARLEAEAATADGTV PEMGALPYTEAFVKEVLRLWPPTWLIGRTVRRDTELDGWRLRTGDQVMFSMYRLHRDPR WWSEPDRLVPERWLDPHSTPVRHTYLPFGAGPRVCVGTQLGMMQLTLATFWLVGGMEIT RSEGAAVTPDFGGLLLPRNLSVRLRRKSSLRI" gene complement(79611..80711) /locus_tag="EES43_RS23700" /old_locus_tag="EES43_23325" CDS complement(79611..80711) /GO_function="GO:0019104 - DNA N-glycosylase activity [Evidence IEA]" /GO_process="GO:0036297 - interstrand cross-link repair [Evidence IEA]" /codon_start=1 /inference="COORDINATES: similar to AA sequence:RefSeq:WP_010060584.1" /locus_tag="EES43_RS23700" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23325" /product="crosslink repair DNA glycosylase YcaQ family protein" /protein_id="WP_124270589.1" /transl_table=11 /translation="MSDAGRIDVTREQVLAYRVAAQGLDRSLAAPEVLALGVQDTPYGS ARIALAARGASPDGLELVWSFRGAPHLHRRAGLPALAGALWPLDDADATARISTASIRE GARLGLAAFRATAEAFRAAVTEPTAKGEVSTAVSAAVEPSLTYWCATCGARHISGLLFQ QAALFGSVGVAAERGRTVLSPLAEPFPVPEAASGTAGLVRAYLRFLGPATPAEAAAFLG TKPAVVRAVWPDGLAEVAVDGRSAWLPESRLPELRAATSGDAVRLLPPGDPYLQARDRA LVVPERGRQKEVWRPIGGPGAVLAGSEVVGIWRARSHGAGGGGGTVEVTVTAFAPLPAA VRRSVEAEAGRVAAARGAEGARVRFA" gene complement(80907..81401) /locus_tag="EES43_RS23705" /old_locus_tag="EES43_23330" CDS complement(80907..81401) /GO_function="GO:0003700 - DNA-binding transcription factor activity [Evidence IEA]" /GO_process="GO:0006355 - regulation of DNA-templated transcription [Evidence IEA]" /codon_start=1 /gene_functions="regulatory (smcogs) SMCOG1135: MarR family transcriptional regulator" /gene_kind="regulatory" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_015612037.1" /locus_tag="EES43_RS23705" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23330" /product="MarR family winged helix-turn-helix transcriptional regulator" /protein_id="WP_124270590.1" /transl_table=11 /translation="MTATEPSRLTSPGRNPELRVSGRYFSRLARERPDIAMCRAATLAA RVIDEELAGRRLTASQHLVLKMLDDVGPCSQQELSEQLRIDRSVMVGCIDGLEGSGLVR RDRHPRDRRAYAVTLTAEAAAVLEAAEDSVPRLLDRTFGALTAAERRTLTRLMGKILDA D" misc_feature 81585..81603 /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: strong, score: 32.19" /tool="antismash" misc_feature complement(81590..81608) /note="TFBS match to DmdR1, Iron(II)-dependent repressor, confidence: weak, score: 24.27" /tool="antismash" gene 81639..82688 /locus_tag="EES43_RS23710" /old_locus_tag="EES43_23335" CDS 81639..82688 /GO_process="GO:0015891 - siderophore transport [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1033: iron compound ABC transporter, periplasmic" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012378643.1" /locus_tag="EES43_RS23710" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23335" /product="iron-siderophore ABC transporter substrate-binding protein" /protein_id="WP_124270591.1" /transl_table=11 /translation="MLGFTRVRRHTLAASATAAAFALVLVGCSSDGDGGKTGAKDAAGS GGAFPVSIKSSLGTATIDEKPERVVTLGQGSAETAIALGRTPVGIESYPWGSDKSGYLP WINEAVKKSGDELPQQFTGGEEIDFEAITELEPDVILAPWSGITQKQYDVLKDIAPTVA YPDQAWSTDWDQQIDIIGKALGRSEDADGLKTAIEKQLADAAATRPDYRDVTFSYIYNS GPGTLGVFKPEEQRVKMVSSLGLKVDPVVDTFKETPGTDSALIGLENAEKLKDSDIVFT FYTDAKNREEIEGQKLYGAIPAVKKGAVVAADDNSFVTASSIINPLTVPWTIERYLPII DKAVEAAGK" gene 82739..83776 /locus_tag="EES43_RS23715" /old_locus_tag="EES43_23340" CDS 82739..83776 /GO_component="GO:0016020 - membrane [Evidence IEA]" /GO_function="GO:0022857 - transmembrane transporter activity [Evidence IEA]" /codon_start=1 /gene_functions="transport (smcogs) SMCOG1011: transport system permease protein" /gene_kind="transport" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_012378642.1" /locus_tag="EES43_RS23715" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /old_locus_tag="EES43_23340" /product="iron chelate uptake ABC transporter family permease subunit" /protein_id="WP_124270592.1" /transl_table=11 /translation="MATTTAAPPSGAGASRAGAARSAALLLAGSAALALALCASVMFGS RGTSFGDVLDVLTGSAGPDVTVIVESRYPRTVLGVLAGVCLAVAGTLMQGVSRNPLAEP GLLGINAGASASIVAATAWFGASGATDTMWWALPGALLAGVLVHVIGSAGTGVGVVRLV LAGAVLTAVLTAFVQAVTLSKPRVFDSYRYWVVGALGGRDFDVFLCVLPFAATGLTLAL ALGPGLNALALGDATALGLGSHPARTRAGGLLAATLLSAAATAAVGPIAFVGLAVPHVV RALVGVDFRFQILFSALLGPTLLLLADVVGRVVMRPTELMVGVVTAFIGAPALLVAVRR MKGAS" ORIGIN 1 aagccccggc gaggtccgcg cgccgccgag gccgagacca ccgccctggt ctggctgcgc 61 gaggacatcg cccgcgacct cggcctcctg gacgacacca cgttccccga cgaggctcgt 121 gctgcctggg acgaccaggc cagggcggcg gccgacctcg ccaccgccga gaagaactac 181 tacgacgccc gcgcgaaggc ccgggagacc tggctcgacc tgagcgccga cgagcgggcc 241 gcgctcggcg gcgacggccg cccgaccgtc ctgccccggc cgatcgccgg gtccccggcc 301 gtcgccgcct gggaagccgc ccgcgacgac gtacgcctct ggcagcagcg ggtcgacggc 361 gccgccgccg accaccaccg cctccacctg gccgccaccc gcctcaccgc ccaccaccag 421 ggttcgggca cggtcccggt gaaggacgcg ccgcaggagt acgccgcacc ggactggcgc 481 tccgaggcgc cgaagcccca ccaggtcacc gggaccaccg ggaccgcccc gcgcaccctg 541 acctcgccgg acggccgcac ggtgcacgag gtgcacgaag tcccgcacga cggggcctcg 601 ttcttccacg cgctcctcgc gacggcccag gaccggggca ggctgccgta cctgctcgac 661 gccggcctcg cggaccggtt cacggccgac cccggcaacc cggaggtcac cgccgaggcc 721 gtcgacgccg cacgccaccg gctggcctgg gcgctggccg acgacggcaa cgaggacctg 781 ctcgacggtc tggccctgga tgcggcggac accttcaccc aggacgaact ggacgcggca 841 gggctggagc tgaccccggc ccagcaggcc gagttcgacg cgctgggccg cctcccgcag 901 accctttggc cgagcccgga acagcgggtg gccttggcca cggcagccct gtcccgcccg 961 ttcgccgccg agcccgcggc gacgacgccc gacaccgaaa gcccggcccc gcccgagcgc 1021 cgggccggtg accacggcgg agcggacctg ttgcccgcgc tcgcggcccg ggtcctcggc 1081 accccggtga cggtggtgac gggggagggg cggcagcaga tgttcctgcc gcgcggggcc 1141 gacccggcga ccgccgatcc ggccaccggc ccgctgctgt tcgcggcgga cggcttcttc 1201 tccgccgccc tggcgcccgg cgcgacgccc ccggtcacga ccgcgctccc gacgccggcg 1261 acgaccacgg cgacgggttc gacgcccgca ccctccggtg agagcacggc cccgggcacg 1321 accagcacca cgggcaccga cgggaagccg cccgcccatc gcagccacgc caccccgccc 1381 tggctgccgc ccgccgacgc caccggcccc cgctaccgtc tggaccgcga cgggttcctc 1441 accggacccg acggggccac cttcacccag ggcagcccgg caggccgggg caacggcttc 1501 ttcgccgcgc tctccaccgc cctgcaccac gcggccgatc agccggggcg cgaccggcca 1561 gaggcggcgc ggctccgagg acgggccagg gtgtcgcccg cccaactgat gcgcctcaac 1621 gggctccccg gcgaccgcgc cgagcacgag gcgctcttct cgcccccgcc gctcaaggtc 1681 cggccgggcg cgcccgcccc gagccggagc gcccttgacg gtcatctgcg ccgtcacctg 1741 gcggatgcgc cgtgggggcc ggaggccgac cgcgcggtgg ccgagtgggc cgccgccgcc 1801 accgggacga cggtgacgct ggtcgaggag aacggcgtcg tccacaccta ccccggtccg 1861 tcccccgacg cccctgtgct ccgcctccgc cgtcgcggcg gcgacttcgt acccctgctt 1921 ccgcgcaccc cggccccgtc cccggctccc gcgccggaga cgaaggaagc ggtcgagaca 1981 ccggaggagc cgaaggagtc cgcaccgaag actccggaac cgacggcggc cgaaacccct 2041 gaacccgagg cggcccagac gccggaaccg aagcgagccg aaacgcccga ggagaagcct 2101 ccggccccgg ccacgcccac ccctccgccg accacgcccg ccccgccgga gacgaccgcc 2161 gtcaacgaag cgccgctccc gccgcccgcg tccccgaccg gtagcgatca ccccgggttg 2221 cagggcgagg aggaggcgta cgaactcagc accctgtccg gcgctgagtc ccagccgcac 2281 gatcgcaccg actccgactc cgactcggag atcgagaccc ggcggggcga ggaccccgga 2341 gccgacaccc cggccccggc ggtgccccgt gacgccgggc tgaaccggtg gctcaccggc 2401 cagatcaccg aggacgacct gcctcccacc cacgacgcgc ccggccccgg ccccgaggag 2461 accgtgagca tcgcggagct gatcgaggcc ggcggcaccc cgacccaggg gcagcgcgcc 2521 gaggcgatgc tgcgcggcga cgaccggctg cccgccgccg ccctcacccc gctcgacctc 2581 acccgggtgc ggctgacccg ccccgggccg ccggcgcgga cgctggacac ggtggccgcc 2641 gccgtcgcgc ggcggctgtg gacgcagacc cgcgccgagc tcaccgccgc cgcgcccgaa 2701 gggctggacg ccgaccagat caccgacgcc tggtccacgg ccgtcgccct ggtgctgccg 2761 cgcgaaccgc atccggtgct cgccgacgtc cggcacgcca ccgacggcca ccgcgacgcg 2821 gtgcgccgcg tcgccgcgca cctcctcggg gcggcccccg ggaccgagga cgcggcccgg 2881 tccgccgtgg agctggccga caccctgcgc gccgggctcg gactgccacc gcgccggacg 2941 tcggccaccc ccgccccgcc gcccgcgcga accgccccgg taccgccccc cgccgtccag 3001 tcgcagcccg acgcggacct gcccgacctg gacatgccgg acgccggtcc ctcggccctg 3061 gacagcttcg acttcgacgc cctcggggag gtggacgcgt tcgacttctc cctcctcgac 3121 acgggcccgc ccgacgcgga ccagggcgac ctggagatga cggatgccga cgcggccccg 3181 cccgcccccg tcgcgctgga caccggcgcg gggcggccgg tgttcgcgac gcccgccgcc 3241 acccggccgt tgaccaccct gccgccgctc agcctcgtcc cgttcgcccc ccagcgcacc 3301 acccccgacg acggcgccga acaggaactg gaaaaactgg cccgccgggt ggcctcggcc 3361 gcactgcgca accgcctcaa caaggtgccg ccgccgcgcg tggacatcgc cggatacggc 3421 gccgatgcgc gcggggccgg caccgcccgc gaacgcgacc acgccgcccg ggaacggggg 3481 gtccggcgag cgctggcggt gcgcgagctg ttcgtcgcga agctgaccca ggcgctcgcc 3541 gatctccagg ccggcctgcc cgccgggcgg acccccatca gggcgaagga catcgccgtc 3601 accgcccagg gccgcgtccg ggtcccgacc cagggcgtca ccgtggcccc ggaccggtgg 3661 atcagcagcc cggacctcgg ccgccaggcc acgatcagca tcgcctcgcc cggacacgcg 3721 gccgcggtgg agaccctgga cgccctgcgc cgcatggacc gcaggcccgg ctccggcacg 3781 ctgcgctccg gaccgctgga cgtggacgcg gtgctgcgcc gggtgctcca tctggccccg 3841 acggtgttcg tcgaccccga gatgcgccgg gacctctaca cgatgaccga gcgggccctc 3901 gccgcgggcc gcgccaccag cctggccgcg ctcaccgcct tccacctgga ggaggagggc 3961 gtcctcgccg ccgaccgcgc gcggtacgtc tccgaccagg ggcaccgggt gccgggcctg 4021 aactggaccg gccccgacac cgccgacgcc aacatgttct tcgtggaccg gatcgacgcc 4081 gggcagccga acggccaggg acaggtcgat tcggcgccat ggatgttcga aacggcggtg 4141 tacccggtgc tggcagacgg cagccacgac cgggtggacg ccctgctgcc ggacggcagc 4201 acgtggcaac tggacgagga ggagttcgcc gaactggtcg cggccgacct ggcccgcaac 4261 ccgctgcccg cggacacccc gatcgtgctg gccgtgccga tggcgggcga ccgctacctc 4321 gacctgccgc gcatcctcgc cgaacgcacc ggccgcaccg tgtgggtgca cagcgggctg 4381 gcccagcgcc accccgaccc ggccgcgccg agcgccatcg ccgtcctgca ccgcgacgga 4441 ctgccggacg gcggctggct cccgcagtac ccggggctgg ccccggcgcc cggtggaccc 4501 gactggcacc gggacgtgct gacccagccc atcatcagca gcagcaccgg gcggcagatc 4561 gggcggtccc tgcacgtccc cgccgaactg gtcggcgagc gcgagacgtt cgccgacttc 4621 gaccagatga aggtgtacgt ccactacaac gccgccaccg gcacctacag cgccaagctg 4681 ccgctgaccg ctccgggccc gaaggggaag gcgtacttcc tcgccgggca cgggctgccg 4741 ggcaggctgg acctgcccct cgccggcggc ggctcccgca cggccggccg gcacgaggcg 4801 ggggagtggc tgcgcaggcg caagagcctg tcgtccctgc ccaaggacca ctggatcgac 4861 ctggtggtct gctactccgc cgccccgacc gacgacgccc tccaggacct gtcgcaggcc 4921 gggcactcct tcccggtgcc gttcgccgcg gacccgctca gcgacgacgc gctctccctc 4981 ggccagcacc tggcgaacgt caccggccgc agggtgcgga tgtcgtactc cgtccagggg 5041 gcggcccgct accaggacga agcgctgcgc ctgctcttct ccgacgcgcg gggccgccgc 5101 tggtggtggg agaccgcccg cccggagccc gacgaggcgg agctggaccg gatggcgggc 5161 gtggccgggt tcgagggcgg gccctcgacg gtcgcccggt ccgaactgct gcgcctggtg 5221 cgggccctga agctcgtcct ggggcaggac gtgcaggacg ccgacgactt cccggccctg 5281 ctgcgcgggg ccgccgcggt gggcagcatg tggttcgccg accccgccct ccagcccgcc 5341 ggccccttct cgccggagct gctgcgtcga gtgatcgccg cccacccgct cgccgccgcc 5401 ggggtggacc ggcagacgac cggtcgtgtc ctcgccgacg ccgcacgggc ctggacggac 5461 tcacggatcc cggtgagcgc gttcgtggac ctgccgacac cgctgtcggc ggccggatgg 5521 ctcggcgaca cggccgccgt ggacgatgcg gcggtcgccg ccctcggcct ctccgacccc 5581 gtccacgccg ccgcccatcg gccccggatg ttctgggcac gggtccgggc cgaggagacg 5641 ctggccggac cggacgggga cacgctcacc actcgtgcgc tgcggctgga cccggccgtc 5701 gacctcgacg acgctctgcg cgaccgcgcc cgctccgtgc tcacccgggg cttcgcggcg 5761 agccgggaca tgaccgaccc ggacgtcacg ggggcctatg ccgtggaggc cgcgggagcc 5821 ttcgactcca ccggggtgat ggtcggcatc agcggcggca ccgacggcgg gcgtgactgg 5881 cacgaccgct cgtccttcct gcccgatctg agccggttcc gtctgaagac cgggacgacg 5941 gacacggagc agaacgcgcc gtgggcgggc caggacgccg acggcaacgg tcggccgacc 6001 ccgtacctcg tccgcgcctc ggtcaacccg gaggacagcg cccacgtgga cgtggacctc 6061 ggcggtacgc ggcaccgggt cacgcccgcc gagttcgccg aactcctggc ggccgacccg 6121 gtgctgcggc gcaaggcgct caccaccccg gtcctgctgg ccctggaggg cctcgacgga 6181 tccaccaccg ccgtcgcgga cgccgtcgcc cagcggctcg gccgcagcgt gtggtggagc 6241 gcattcccga tgacgctctc cgccaagaac gtgggagatc tcgatgtgcc gaccctcggc 6301 gactccctgg cccggctggc gagcccgacg gtggctgacc tgcgggaggc ccgccccgcc 6361 gccccgtcca tggacgagga cgtcgcgcgc ccggtcgcac cgccgacaca ggccgccccg 6421 aacaccgccc cgccggtgcg gacggcgccc tcgccgcagc tgcccggggc cggggaggcg 6481 accaccgcac agacgacgcc ccggtcgccc gagcccgtac ggtcgccgga gcccggcccc 6541 gtaccggacc acgctccggc acggcagtcc ccctccaccg acgaggccgc ccccgcgacc 6601 gccgccgcgg cgagccgtac gcgaggcggg gcgcgttcgt ccgccgggga cccgatggtg 6661 ggcgtggagc tgacctcccc ggccccgata cccatcgctc cggtacccgg gcagccggtc 6721 cggccgctgc cgccgctgcc cgttcggacc ctggtcgcct acggacggga cgagacgagc 6781 ccgtccgtgc agggcgaaca gaccctcgcc cggctcgcgg cccaggccgc cgccaccggg 6841 ctccgcaact ggcgcgcggg cgccaccttg ccgcgcgtgg tgatcaccgg ctacggggcg 6901 gacgcactcc ccggcggagg cgcctccgga gcgcccgcga tccggcgggc caactccgcg 6961 cgcacccgct tcatcaggct gctgacgctg gaactggaac agctccagcg cgacgtgccc 7021 gcggacgagc cacggctgac cacgagtgac tacccgctcg tcgtcaaggc cctgccccag 7081 gttccgaccg actgggtggc ctccggcggg ctccagcacg tcagccgggc ccagctgggg 7141 cggcaggcga ccgtcggtct cacccaggcg gccgacgccc gggcggtgca gaagctggac 7201 accctgcgcc gccgcgaccg gtccctgcgc gaccgcccct tcgacgtgga cgccatcgcg 7261 cgccgcgtgc tgcacctgga accggacgcc gacgtggagc acgacgccag ggccgagctg 7321 ttcgccctgg tcgcccgggc gacggcagcg ggccgggcga ccggcgtgaa cgcactggcc 7381 gcgttccacc tctccgaact gggcgtcacc gcgccggacc gcgcgcacca cttcaccatc 7441 tccggacaac gggcagcggg cctgaactgg acccacgagg acgtggtcga actcgacccc 7501 acccgcagcc acgtcctgct gaagcccgac aaccggatga cggggctgtt cgcccccgtc 7561 ccctgggcga acggccccac cccttacgtg gtggccgccg agggcgggca ggaccgggtg 7621 gaggtgctgc tgccggacgg cacgacgcgc gagtcggcca tggacgagtt cgtggaactg 7681 gtcgcggccg acgtgacccg cgaggcactg cccccgggca cccccatcgt gctggccgta 7741 ccgttcgccg gggacggcga cctcgaagcc ctgcgcgtgc tcgccgaccg caccggcctg 7801 acggtctggg cccgcagcgg cgacgtcgac ctggagaccg tctccggccg ggccgccacc 7861 gtcaacgtcc tccgcagccc ggacgaccga caccccttcg gggactgggt ccccaccgtt 7921 cccggcctgg ggccggacct ggacgacgac gtgccggact ggcaccgcga cgtggtcagc 7981 cgcgccatca tcagcgcccg gaccggccgt cagatcgggc gcgcgtccta ccatcccgcc 8041 gagttcgcgg agttcttcga ggagcacgac cgccacctgg accggatgac gacctacgtc 8101 cactacaacc cggccaccga tcgggactcc gtggagtacg acctgccgcg tccgggaccg 8161 gaggaccgcg cctaccggct ggacatgcac ggctccccgg gccgcctggt gctggccctg 8221 cggaatggcg ccaaacgcag ggtcgacgag cgggaggcgg gcccctggct gcgccgccgc 8281 aagagcctga cgaccctgcc cgaggaccac tgggtcgacc tggtctcctg ctggagcggc 8341 tcgcccgtcg acagttcggt gcccgcgccg ggccgtcgta ccggcgcgtt ccccggaccg 8401 ttcgtccccg acccgttgcg gacggtgtcc atggcgcagc acgtggcgaa cgagacccgg 8461 cgctgggtgc ggctcgccca cagcccccag accaccgagg agagcaacgg ccgctaccgg 8521 cgtgtgctgt ggaccgacgc gcagggacgt gcacgggcct gggacctggc ccggcccgag 8581 ccggacgagg aggagctgga cgcgctggca caggccgcgg ggctgagcct cggcgacgac 8641 gaggtgtcgc gggaaatgcg cgacgccacg ctccgcctgg tgcgggcgct gcggacgacc 8701 ttcggcccgt acgtcgacga cgagccggac ttcggcgacc tgctgcgcgg cgtggcggcg 8761 ctggaccaca tgtggcggag cgatcccgag ctggaccagg ccggaccctt cacgctggac 8821 ctgctccggc gggtcgtcga cgcccatgcg ccggtcgcca ccggtgcgac gcgagcgagc 8881 acccgggcgg tgctcgccgc cgccgcacag cactgggcgc gggaccccga cagcggactc 8941 cagggcttcg tgcggctgcc cgccgtccgg agcaccgccg cgtggctcca ggagggcggc 9001 gtcgaggacg aggccgccgc cttactgcac ctcgacaccg acgaggtcgg cgaggcggag 9061 atgtcgcgga tgttctgggc ccgggtcaag gcggcggaga cgctcccgcg gcacgatgcg 9121 gacgccgccg tgtacgtcgg acgcctgctg cacctgccgc ccgtccagga accggccccc 9181 ggtgacgaac ggctcgacaa ggcgctggac gtgctcaccc gggccttcgc ggtgggccgt 9241 gcggcatccg acctcgatgt cgcggcggct ttcagcctgc tggacgaggg cgcgaacctc 9301 tacaccatga cgtacctgac gcagggcacc gccgacggca ccgggcggaa ctacaccggc 9361 gccatgccgc aggacgcgga gctgagccgg ttccgtaccc cggacgggct gcacgacacc 9421 ccgtgggtgc gcgacgcccg cggggagagc gcgccgcttt ccttcctggt gcaggtcgct 9481 ccggacgcgg acgacccgga cctgctggag ctgcggtgga agggggagac gtaccgggtg 9541 acgctgggcg agttctccga actcctcgcc cacgacccga tgctgatgaa gcgcgagctc 9601 tcgacccccg tcgtcctcgc cttcccgggc ccggccgccg accctgaggc caccgcccgc 9661 cggatcgccc agcgactggg ccgtggcgtg tggtggaccg gcttcccggc ggacctctcc 9721 ggcacggacg actccggcga acccgtgctc agcctgcacc ccacggccga cggcgactcc 9781 cccggccccg acccctggca gcaggcccgt cccgcgcagc ccgcctccgt acaggacgca 9841 ccgcgcacga tcccggctcc gctgccccgg accgccgggc gggacgaccg gaacgaacag 9901 cccgaagccg tcggggcgtc agcgccgccg ccggagccgg ctgccacggc ggaggccgtc 9961 ccgcccggga cgtcgggctt gcctccggag tcctcctcgc ccgcggtgac ggggcccgct 10021 gggaaggatg cgcggccctc ggagcccgca cggccggtgg acgttctttt ggcgccgccg 10081 gttcggcagg cggggaggga tgcgattgac aactggctgg agatctcggc gcgcggaggg 10141 ttgcgtcgct cttccgcgct gcgtgccgtc gatcaggcgg tgtcgcgtct tccgcgtgac 10201 gcggggcgtg atgaattgcg gagtgtgctg gtcagtgtga cggactggaa gagcggcaag 10261 agcccggaga gcacgcggtg ggaggctgtt tcacgtctgg aggcggcggt ccgcgacagg 10321 atggaccagc ttgctgctcc tcctgctccg ggtgtcttcg tccgggaccg atcggagcgc 10381 gcttctgctg gtccttcgcg gcgcgacgag ccgcctgccg cggtgccgcc gcgggtctcc 10441 gccgctccgg gatcggtgga ggtcgaggga tatgccccct ccagcgggtg ggaggtggaa 10501 ctgcacgggt atcggctggt gctgcctgcc gacgcctacc ccggtgagtt cggcgatcac 10561 aacggcgccg tcgttcagct gcccggcatc ctgaagatcg tgctggacca ggccgggggt 10621 gtgccgatcc tcgaaatcac ctcggaggcc gcccgtggcc tggtgcgggg acgtgcggac 10681 ggccgggccg aacggtccga ctcgctggcg ggcctctccg gtgtggtgga ccggctccgg 10741 aaggcgcggg acggagcgac ggtcaaggag accttcccgg agtcggcggg atacgaggtg 10801 gatccgctct cggaggatct gccgatcaag accaacgaag ccggcggggc cgccatgctg 10861 gtgcatcaca cggcgaccgc gccgacttcg caactcgtcc agttcatcga gtacgtcacc 10921 agccgtatgc ggcgggagtc caagccggtg cagctcgccc acgcggacgc gggcaacggt 10981 ctgcgtttcg gcgcctcggc ccgtcaggac ttcaccgact ggctcaaccg tcgccccgag 11041 cagtaccccg tgaacgcgat ggacgacaag gagttggagg gcgtactcgc gctcgggtac 11101 atccaggtcg cggccgctgt gcgaggagca cgcaacaggg ggatcctgcc gaaggacttc 11161 acggcggtgg cctcccgcca tccccttgcc gctcttcggg caagtctcgg tgaggcgcct 11221 cgcgcgtatc tcaaggacca ggaagaggca ctcaggaagc ttttcgtgag caccttcgag 11281 gacgagatcg acctgagggg ccggagcgta ctcgacctgc ggatcggttt gacggtcgga 11341 ccgtcgagcc cgacggtcca cgagtacctc gacaacctgc tcctggacga gccgcaacgg 11401 atcgtgaccc agcgccaggc tctgggaatg cagaccgagt tccccgcact ggattcccat 11461 cccgacggcc ggagtggtga agcacgcatc gtgcctcccg tcgtcgtcat ggaggctcgg 11521 gcgttggcct cgatgagaga gactctggag accctcaagc gcgacgccga cgacatcgcg 11581 gtcttctccc tcggcctgta caacgaggga agggcccttc acgggctgcg cccggtcggc 11641 tcgcccgtcg ccccgacgcg gcaccagccc ccccggttcg ctccgcctcc catgtcccgg 11701 ccctcaccac gaccggccgg cggtacggtg ccggccggcc cggccccggc tccgtcgccc 11761 gttccgctcc cgccggctct cgcgaagacg gcggcacgtc tgatcgcgat ggacgcgggg 11821 gcgcgtgcgc gggaactcac gtcgctggct ccgggggacc gagagctcct ggccgctgac 11881 ccggagttcg tggagcagtt gcggaccggc ctgtccgcgg acgacttcac ggcaacggcg 11941 gcgcggttgc tggtcgtcgt tcccgagggt gtggaacagc ccgtggctgc cagggaggaa 12001 gcggaggccc tggtcgcgga gatgctcgcc gacccgcaga tcgcggtcgc gctgctgacg 12061 cggggccgac ggatgatcgt cgttccccgg gaccggccgt tgacgtcact gcccgagttc 12121 gccgcgctcg cgaaacgccc cgagaccgac ggccggtcgc tggacacgga acgagggctc 12181 tacgccggcg gcctggtcgc cgtaggtgag gagaacctcc tgggtgagac caccgcggta 12241 ccgctcgccg atgtccagcc cgatggatac tccatcgccc gtcatgagtg ggcgcacgcg 12301 atcgagtcgg tcctgaacga ggaagaccgt ggatggatca ccgacgtgta ccggacgaag 12361 gtgaagaccg aggcgcaggc acaagggcag gcggaggagc aagcgcaggc gcggacgaag 12421 gcgggaggaa gagcggaagc gcaggccgag gcgagagcga gggcgcgggt gcaggccgct 12481 gtcgactcgg tcgtgcaatg gccggacggg cccggcccca actactcgtc gagcaaggcg 12541 cacgagtatt tcgcgcagct caccaacgcc tatctcggtg cgaacaccgg cagggacgcc 12601 gactcgcgcg gccggcgcaa caacggctcc gactgggtgg agcagcacga ccgggaactg 12661 cttccgctgc tgcgccggct ctacggcccc ggccggccct ccgacctcgg cagcggtgac 12721 aacccctacg ccctgacagg cttccgccaa ctctgggacc aggccgagcg cgagccggcc 12781 tcgcaggagc ccggatcaac ctccgatacg caggcggtcc gttcccacgg cggtccggat 12841 gtggtgtccg gggcggctgg acgtgttgcg ggtgacgcgt ctgatgaggc gatcctgttg 12901 gcccctccgc cgagtggttc gccgtccgct ccgccccctc ctacgttgat cgcgttcgat 12961 gctcagggtg agggaagaga gctcgcctgg tcggacgtcg agcagttgcc gtggtatccg 13021 gggcttccgc cggtacagcg tgagcggttg cttgcgacgg aggactacac accgctcgag 13081 aacgcgatgg acgggatgcg caatacggtg gtggctgccg tggacggcgg agcgggcgtg 13141 gaggacatcg aactcctcaa ggccctgttt cacctgcggg gaaatctcag tgctttcgat 13201 ccggtgatgc aggacctcat gcgccaggct gtggagagtg cggaagggcg ttcgcaacag 13261 ctgtcgttgg tgcgcggctc tgtcacggac ttcggccggc atgtggcata cacggacctg 13321 atcgttccgc accccggtcc gtgggcgatg gactccacgc ctcagggtct ggcggctgcg 13381 cttgagtatg tgctgggtga gcacagtacg gcgacggtcc tcacggacaa cgagacgctc 13441 ggccacagcc agtcggaaga actgcggcgc aacatcgaaa agatcaacgc actcaacgcg 13501 gacaggggcg agtacgtgcc gctggtcgtg aagagatccc cgctgtccgt cgtcatgaac 13561 gagaaaggca agcacaagac cgccgtgttg ggtgtgccgt tgcggctgcg ccatgcgccc 13621 tccttcttcc aggtgaccgt gacccgtgag ccgtgacgaa ctgccggagc actgggagga 13681 gaacgacggg tgtaggggcc ccgggccccc ctgcccggcc caccgcagcc ccggctaccg 13741 catcaggcac accctctgcc ccgaccccac gtcccccagt gaacgaggac acgatgactg 13801 agtcccgcgt cgagaccccc gcctccctcc tggacccccc accgccggag gaattcgtcc 13861 aggccgcccg gctggcgccc ggccactggc tccacctcac cgaccccgcc tggccggggg 13921 agggcgcgcc accggactgg gcggtggtcg ggcggtggcg ctccgacgcg gcgggcgaga 13981 tcgtcgagtg ggaggacaac gaggagtacc gcccgtcgcc ggaggccatg ggctggcccg 14041 aacccgccga cgacgtggac cgcgccatcc agctcgccac caccggctac gggccggccg 14101 aggatgtcac cgccgccctg gcccgcgccg aggtcgcggt cccggtcacg gcgagcggcg 14161 acccggtgag catgtccgcc cccgacggga cggccgtggt ccccgcctac acctcgcccc 14221 gctacctcca gggcctcgga caactgggct ccgtgaccct cccggtcgtg gacctgctca 14281 cccgtatccc ggccgaccac agcctgtgcc tcaacagctc ggccgcggtc agcatggtgc 14341 tgaccacgga gggcctggcc gacgtgctgg cggaggcggc gacgaagggg aggaaggcgg 14401 aggacacacc ggaggcggca gggcagccga accgctgaca caggacgcgt cgacgcgcgg 14461 acgggaccgt cgggcggccc gtaccgtcgc gccgcggggg tccgcgccga gcgcgggacg 14521 aacgagcacg gggcatgagc gatgtccgcc ccacgcggcg gggccgcgcg ggcgccctgc 14581 cgccgccttc cccgcccttt ccgtttcggg ccgacgtcga cggcgaggcc gacgtgccct 14641 ttcgggcagc cgcatcggat cgatcgggga ttccgtccct gcggtatgcg cgggttcagt 14701 cactttgcgc ggtcatccgt gacgagccgg ggttcctccg tgacgcggcg ggggcgcggt 14761 ccgcttacgc ggccccgcct gccgaagccg caccgcgccg gggcaacgat cttccagcgc 14821 ttgccatgcc ttgacatcgc ttgtcacgcg cagctcaata agcctcgcaa ggcggcgctc 14881 tgccgtccgg ttctccgcca cctcctcagc gtgctcgtca ccgggatttc tccaaccgcc 14941 ggagtgctcc atgaagttca tgctcacccc acgcagaagg acggccctcg ccctcgtcgg 15001 cgccgcgtcc ctgctgtggc ccgttctgtc gccggtcagc ccgccggcct ccgcgagcgc 15061 gggatcctac gacctgctgt acgaccccgg cccctcgcac aactgctggg gccgcatcgt 15121 cgacgacgac ccgaacaaga gtgatcccac gcgcgtcaac acctccggct gcggcccctt 15181 cgccgcggac aaggagttcc agcgcagcgt gaaccagccg gagaagtctc cgacgtggga 15241 catgggcacc ctggggtgga acaccgccga ctggggcagg actccgggct tctcgttctc 15301 ggcgcagacc gggtccaaga cggtgaacat gacgaacagc gcggccaaca gcgactgcgg 15361 cccgctgcgt gagaccaacg tgagctacac gtaccagaac tcccagttgc gatggggctc 15421 cgaccgcaag aagctgacgc tgggcgacgg gaacgtgaac gtctcctaca acgcgtcggt 15481 ccgccagtca gggtctttca cctgcccgga gaagcgggcg atcctcacca ccgacttcat 15541 cttcgacgat ctcaagaacc gtgaaacggc cctgatctcg gtcgtccact acgacgccca 15601 gaacgccttc acgggcccgg tcgccggaga cctggtgtgg aacacgctga accccgacgg 15661 caagtcgtgc caggccgggt acggctgccg cgtcatggtg aagagcccga cgggcatgct 15721 gggcgaagga cagaacgggc tggtcagcga caacatcagc gccctgttcg accagtacgc 15781 gcgctacctc aaccccggca acctgccgaa gtccaacttc tccttccggg gccttcagat 15841 cgtcagcagc aaccgcggaa cctccacgac ctcgtccgtg agcaaggtga gcgccaccct 15901 caccccgaac gggcccgtca ccacgacgct gaggaaccgc gacaagcagg ggaacctctg 15961 cctggacgtc aacaacaacc agcagacgtc tcccgccgac gcccagatct acacctgcaa 16021 cacgtcgtcc gcgcagcgat ggacggtagg accggacaac acgctgaggg cgaacggcct 16081 ctgcctggac gccgagggcg ccggcaccgc gaacggcacc gacgtgaacc tgtggacctg 16141 caacggcgga cagaaccaga aatgggtcct cggccgctac ggccaggtct acaaccccgt 16201 ctccggccgc tgcctggagg tcgcgggcgg gagcagccag agcggctact cggatctcca 16261 gctctacgac tgctggggcg gtgtgaacca gaagtggtgg acgccctacg gagacttcca 16321 cgaccagtga gtgccggccg ccccatgccg agcccgaccg ccccaccggc caccaccccg 16381 ccggtgtgag cgcgacccgg tcggcgaccg gttccgcgac cggttccgcc tccgtcctca 16441 ggacggtggc cagcgcctcc cggcccgtac agggcccggg aggcgctgcc gttcgcggtg 16501 accgtccgac ggccccgcga cgggtcctgt cagccgggcg tcggcggccc gccgtccgca 16561 tcgcgccggg ctaccaggcg gtacgcgttc gccagccgca gcggtccggc gaacggcctc 16621 acgaccaccc ggtccagcac ggccgccgcc agcagcagcg gcaccccggc gatcatcaca 16681 gcggtgcgca gcgcccgccg tccggccccc ggcggcgcgt ccagccacgg caggtcctcc 16741 cgcggcgcga ccgcgttcag ggccgaccac accgcggcca gcaggtcgac cggatcgtgc 16801 gcctcggcgt gctcctcggc caggacggtg aagccgcact cggccagccg ccggcgcagg 16861 ttgcccgccg ggaccaggtg caggtgctgc ggctggagcc acggcagcca ccagcggccc 16921 aacagccggg cgaaacggct ctccggatcc ggcacgtcga tcaccagcag accgcccgga 16981 cgcagcaccg cgtgtgcggc ctccaactcg cgctgcgggg aggtgcagtg ctccaggcaa 17041 tggaacatgc tcaccacgtc gtacgagccg ggctgccgcg cggccagttc gggcagcgaa 17101 ccccggtggc cccggcgcac ccggccggcc cgctcggcga gatcggcgcc gtcggtgcgg 17161 tcgatcccgt cgaaggccac cgccgggagc accgcgcggg ccgtctcgca gaagtggccg 17221 tggccggtgc cgacgtccag ccactcggcg gcgccgccca ggtgcggccg tacggactcc 17281 gcccgggaac ggtaggccgc ggcacgcccg tcgaacacgc cgccgagctt ctcctcgccg 17341 aggccgtcgt agaagtcccg gtagtagaag gcgagtccgc gctcgttcag ccgcgggttc 17401 tggaagacgt gcccgcaggc gtcgcagcgg tccagctcga aggcgcccgg cttgtgctgc 17461 aacaggtccg cggtgtgcag acgcccggtg agccggttcg agccgcacca ggggcacgca 17521 cgggcgcgcg gtgcgaagaa ggcgtcggtt ccctcggcca gttcctcccg gtaggcggcg 17581 cgcagcgcgg ccacccggag cgtacggtcc tcgcgggata cggcgttcac ttgtcctcca 17641 tccggccgtc ggccagccgt tccaggtgcc gggcggcggc cggggcgccg ccggcgtcgc 17701 ggaaggcccg cgcgatcgtg cgggccgccg cccgcgggtg gggttcgtcg aggacggtgt 17761 cgacggccgc gccgatcgcg tccgcgccgg accggccgaa gcggatccgc acgcccgcac 17821 cggcgtcggc cacctgcgcc gcgaccaccg gctggtcgtc gcggatgggc gcgaccacca 17881 gcgggacgcc gtgccacagc gcctcgcaca cggtgttgtg cccggcgtgg cagacgacgg 17941 cgtcggcccg ttcgagcagt tccagctggg ggatcgcggg cagggcgatg acgtcccgct 18001 cccggtccgg gccgccgggc gcggaaccgg cgagcgtgcc ctccgggtcg acgatgacgg 18061 cctgcacccg gtcggcacgg gcccgcagcg cctcggccgc ccggccgagg aagcgcgccc 18121 ccacgtccgt gttggcggtg cccagggtga ccaggaccag cctgcgcccg ggatcgagcc 18181 ggtcccaggg gaacgcggcg gggaagggac gggcggtcag cgacggcccg acccagcgca 18241 cccggtcgcc gccccgcgcg gccggacccg ccagctccgg tgtggtgaac gcgagcacca 18301 ggtgcgggga gaagcgcggg tcgccgcttc ccgccggatc accgatccgg gcgcgcagat 18361 cgcgcagcag cgcctcgttc caggcggcga cccggggcat ggtggccagg acgtccgcga 18421 actcggccga ggtcgtcgcc gacgtggccc acggcagccc gagatcctcg gcgacgagtg 18481 ccccggccat cgcctgctgg tcggcgacga ccacgtccgg ccggaatgcg gcgaccgcct 18541 gccgcacgcc cggggccatc gcctcggcca gcggcacgag gaacctctcc cacaggaagc 18601 gcagcgcctc cggcccgcgc acgtccgggg gccgtccggc gaccggcccc tcctcccagc 18661 ccagctccga tccgggcggc ggacacgggt ggacgacggc gtccggcccg gcgagacggc 18721 ggatgagcgc gggctcgccc gcccacgcca cccggtggcc gcgggaggcg agcacggcag 18781 ccacgccgac ggccgggttg atgtgtccga ccagcggcgg caccacgaac aggaagcggc 18841 tcaccggacg cccacccggt ccgccacggc cggacgggag tgccggccga cccagtccag 18901 gacgagatcg cgcacccgcc cgggagcctc caccaggacc gagtgctggt ggcccggcag 18961 cagttcggtc gtgcagtgcg gcagcagcga ccgcatgcgg ggcgcctgcg cggccaggtc 19021 ggagtcggcc ccgtagaggg cgaggaccgg gcagtcgatc gcgcggacgt cgtcgtcgcc 19081 catcaccgcg ctcgccggga tgtcccgggc gatcgtggtg tcgcggacga gctgcgcggc 19141 ggacttcgcc aaccgggcgg tgtggccgcc gtggtgggcg gctatccagt cgagggcggc 19201 gtcctcgttc acgctcatct cgtggcggac ccgccccagc agcccggcga gcttggccgc 19261 ccaggcgcca gtggccggtt ccgactcgat caccaccatg ccggccaccc gttccggccg 19321 gcgcagcgcg tagtcgaaag cgaccgtccc gccgtaggag ttgcccacca ggtgcaccgg 19381 gccgccgacg tcgagccggt ccaggagcgc gtccaggtcg tcggtgaacg ccccgagcgt 19441 gtagccgcgg tccggccgcc cgctgcggcc gtggccccgg tggtcgtaca tgaccacgtc 19501 cagaccggcc gccgcgaagg ccggggcgac ggtgaagtag tagctggcca ggctgtcggt 19561 gagcaggccg tggagcagga cgacggtggc gcccgccgcc gctccggggc cggcggcggg 19621 tgagggagcc aggcgttgga cgtgcagccg gacgtcgccg gtgtcgatga tcgccatggc 19681 tcagacccgc cccgctgcct tgaggcacag gcagacgtgc tcgacgagcc ggcccacgct 19741 gagttcgatg atctcgtcca gctccatgga ggacacgaac tcggcgaagt tgaccagtcg 19801 gccgtagcgc tcctccagca gacccgcgag cgtcaccagg tcgatgctct ccagttcgag 19861 gtcgcggccg aagcgggtct ccatcgtgat ctcggtgtcg tcgaggccgt agtcctccag 19921 cacctgttcg atcatggcgg tcagatcggc gaggaccgcc gcctcgtcgg cccgcacgga 19981 gccggtgggg tggggggtgg tcacgtctgg tccctctcgt catggatggc gcccggtccc 20041 ggctgttccg ggtccgggcc ggtggtccag gccacgatgt acgcgcgtgg gggcagcccg 20101 gggggattgg cgacctgttc gcagctcacc cggtacgtac gggcgggtgc tcccggccgc 20161 cgtacggtga ccgtcagccg gtccggttcc gcgcgggtca ccgcgaagtc gcgcggccgg 20221 ccgccgaatc cggtcccctc ggccttggcg gcggcctcct tcgccgccca gaagcgggtg 20281 aaccacaggg ctcgcggctc tccgcccgcc tgccgggccg ccagcagctc cccttcggcc 20341 gctgagagcg cggtggtgac ggtggcctcc tcgggctcgg cgatctcctc gatgtcgatg 20401 cccggcccgc ggaagccgtc ctccccgccg tccggccctc ggcgcagggc gatggcgaca 20461 ccggcctcgg cgcgatgggc caccgacacc gccggcggaa cgaactcccg gctgtggcgc 20521 ccggtgacgt ggggccggcc cgccgcgtcg ttgccgacga ggagttcggc ggggaagagc 20581 gggccctccc cttccgccca cagcagacgg cgtacggcgt ccttggccgc gatccggccg 20641 agcagccact ggcggcggcc acgcggcggc cgttcggcgt acgccgtgcg ctccgggtcg 20701 ctcagcgcgt tgcgcatgat cagctcccgc gaggcgaggt cgggccagcg ctcgaacacc 20761 agcgaccagc cgccgggccg gtgggtggag agggtgttgc gctccgggaa ccgctcgacg 20821 ggccgggtgt gcgggtcgtt gtcgaagcgg cggtcctgcc agcccgtgag ctgggcccac 20881 acccggccgg agacggtgag caccgcctcc gcctccagca ccgtgtccgt gagggacacg 20941 atccggatcg agcactccac gggtgtcccg gcggccggat gcggtccgaa gaagcgcatg 21001 tgccgcatcc gcaccgggaa gaccacggtc cgctcggtgt gcgtcgccat gatccagtag 21061 ccgagcacct gccccacgtt gtccagcagg gcgcccggcg cgggcggggt ggtcagcgtg 21121 gcgcgcacgt gccggtcgcc gatcgcggac agccgggtca tgccctggta ggccgggccg 21181 tggaacatcc accgctcgcg gtagacctgc tcggcggtgt gctcgggcac ccgttcggag 21241 cggggatcgg gaggttccgg cgcggcgggg gcccgcgggt gccgggccgc cagctccacc 21301 accccccggg cgtgcggccc gaacgacacc gcgacctggt ccggcccccg cggtgcgacc 21361 gtgacgggca cgtccacggg ctcggcggcc gtgacccacc ggtcgaagca cgcgtcgtgc 21421 accgccacgg ccacgctccc gggtacggcg cgctcggcag ccgccatcag atgcgccacg 21481 atggtggtgg cgggcaccac cggccaccgg tcggccacat cgggccagtc ggcgcgctgc 21541 gggaagaagc agtggtcgag caggtacggc atccggtccg cgccgacccg tacggtctcg 21601 tgccggacgt cggtgaggag cgcggcgggg gcggccggga gaggcgcggc ggaagaggcc 21661 gccacggtcg gcgcgggccc ggccggcgcg gacgtccgcg ccgcgaaccc ggcgcggtgc 21721 ggcctcggcg gccgtaccgt accgcccggc cggggcgctc ccgctgcggc gatcagcgtc 21781 gcggccgtct gcgcggtctc gcgcagcagg gccgacagct ccgccgccac cggcgacgcg 21841 gacgcggccg gcgcgagggc ggcggccgga tcgccggtcg gcgcggccac cggtcccaga 21901 cccggcggca ggtccaccag cgcgccgccc aggtcgaggc ggacccggcg cgctgccgtc 21961 ggagcagggg cgggaggggc cgagtacgcg ggcgcggcgg ccggggcggg cgcgtccaga 22021 acgcgggggt cggtctccgc cccggccgtc cacagcgcga cggccacccg ccgcagctgc 22081 gccaggccgc tgcggtgcgg ggagttggcg gcgacgacca ggtggtcccg tccggccatg 22141 gtgtcgccga cgagagagcc gagctgcccc ggcccggcct gtacgaaggc gcggaacccg 22201 gcctcgtaca tcgcctcgac cagggcccgg aagcggaccg gttcgaggag gtggcggacg 22261 aacagggcgc ggacggcggc ctcgtccgca gggaagggcg cggccgtggt ccccgaccag 22321 acggggacgt gcggggcgcg cagcggcatg cggtcggcgg cctcctggaa gggcccgagg 22381 cacggttcga gcatcggggt gtggaaaccg gaccggaacg gcaggacgcg tacgaggact 22441 ccctcggcgc gcagcaccgc cccgaacgcc tccacggcgt ccggcgggcc gcagaccatc 22501 gactggttcg gcgcgttgtc gtgggagagg acgacggagg ggtggccgcc gcccgccagg 22561 acgcgggtca cccgttccgc gtgggccccc acggcggcgt acgccaggtc cgcgccccgg 22621 acggtctcgg ggtcgagacc cgccatgaac gcgtcgacgg ccgactcctc gtacagtccg 22681 ccgacggcca tcgccgtcca ctcgccgacg ctgtgcccgg cgaccgcgtc gggcacgacg 22741 ccgatgcggc gcaggaccgt gtcgagcagc cggccgaccg cgacgacgcc gagcccgtgc 22801 cggccgaggc cgtcgccgac accctgctcc cggctgctcg accccggtgc cgccaacggt 22861 ggccggggca gcccgaagtg gtcggcgatg tcgtccacgt gcggcgcgaa ctccccttcc 22921 agccccggga agaggaacgc ggtccggccc ggcgccccgc cgccgacgag cgggcggggg 22981 ctgaaccaga cgtcgttgcg cccctgccac gcctcgccct tggcgacgac gcggcgggcc 23041 agcgcgagcc gcttgggcgt cgggccgacg atgcccagcc gaaccgggcc cgcaccggtg 23101 acccggccgg gcccggcgtc cgggccgggg ccctgggcgt ggtcgtccag caggacgccg 23161 agcgcctcgg gagtcgccgc gctcaggagc agcaccggtt cgccctccgc gaccgaggcc 23221 cggcgggccg ccgcggcgga gggcgtgacg gcgggagagg gacggcccgc ggcggcgggg 23281 gcctgttcca gtacgacgtg cgcgttgatg ccgccgaagc cgaacgcgtt cacggccgcc 23341 cggcgcggta cgcccggacc gctcacccag ggggccgccc ggtcgatcgg gcggaaacgg 23401 gtggcggcga gcgccggatg cgggtcctcg cagtgcagcg tgggcagcag ggtggcgtgg 23461 tggacggcga gggccgcctt gatcagcccc gcgacgccgg ccgccggcat cgcgtgcccg 23521 atcatggact tcaccgagcc gatcaccggc cggtccgccg ggtccgtgcc gttcggccga 23581 cgcggaccga acacctcgcg gagcgtggcc agttcggcgg cgtcaccggc cggggtggcg 23641 gtgccgtgcg cctccagcag cccgagcgag cccggtgcgg cgggatcgag gccggcggcc 23701 cgccacgccg cccggaccgc ccgggtctgc ccggcggggt cggggttgac cagacccgag 23761 gtgcggccgt cgctgctgac cccggtgccc cggatcaccg cgtagacgcg gtcgccgtcg 23821 cgttcggcgt cggcgaggcg cttgaggacc accacgccgg tgccctcgcc gatgaggatg 23881 ccgtcggcgt cgcggtggaa gggccggatg cgctcgctgg gggagagcgc gcgcaactgc 23941 gagaagacgc tccacagcgt gatgtcgtgg cagtggtgca cgcccccggc cagcatcacg 24001 tcgcagcggc cggcggcgag cgcggtcacc gcctggtcca cggcgagcag cgacgaggcg 24061 cacgcggcgt cgaccgtgta ggccgggccg cgcagatcga gccggttggc gacccgggac 24121 gcggccaggt tgggcaccag gccgatggcg tcctcgggcc ggtcgggccc cagccggtcg 24181 gtgaacgccg tccggatccg ctccagccgc tccgcgtcca ggtcgggcat gaggtcgccc 24241 agcgtgcgca ccagctgccg cgcggtgcgg acgcgctggt cgagccgcgc cagccccggc 24301 gtgaggtagc cgccgcgtcc caggacgatc ccgacccggt cgcggtcggg cagccggtcc 24361 gcgccgcccg cgtccgcgag ggcgctcgcg gcgacgtgca gcgcgatcag ctggtccggc 24421 tcggtgccgg gcaccgagtt cggcatgatg ccgaaccggg tgacgtcgac ctcggcgacg 24481 tcgtcgacga agccgccgcg ccggcagtac acccggtcgg ccgcggccgg ttccgaggcg 24541 ctgcccgggt ggtagtacgc gcggtcccac cggcccgggg gcgcctcgcc gatgacgtcg 24601 acgccggaac cgaggttgtg ccagtaggtc gccaggtcgg gggcgccggg cagcatcacc 24661 gccatgccgg tgatggcgac gggcgcgtgg gccgcgcccc cgtgtgcgga gagggacatc 24721 tcaccgctcc gaggcggtgt ggacgaccga gttgaccgtc tcctcgcccc aggcgagttc 24781 ccgcagcaga gccagggcgc cctcctcggg gtcgatgagg gtgactccgc gctgcgcgta 24841 gtggcgggcc agctccgggc cgaccatgcc ggtgtggctc gcggccgggg cccacgggcc 24901 ccagtggacg gtcagcgcgc gtcgcccggt gcgtgccgcc caggcggagc cgaggcggtc 24961 cagggcgtcg ttggccgccg cgtagtcggc ctggccgcga ttgccgagta cggccgcgat 25021 gctgccgaac agcagggcga aggaggggag ttcgggcaac tgctccaccg cgtcgagcaa 25081 tgccgcggcg ctctcggtct tggtgccgaa gacctgtccg aacgaggcgg gcgtcttctc 25141 ctccatcagc cggtcctcga tgatcccggc ggcgtgcacc actccgtcga tacggccgtg 25201 ctcggcgtgg atctccttga ccgcctggag cacggcgggc gcctcccggc agtccacact 25261 gcggtagccg acccggctgc ccgcggcgcg cagcgcctcc agcgtcgccg tgatctcccg 25321 ccgggccagg accaggtcgg cggcgcgggc cacctcggcg ggggagccgt agcggccggt 25381 gcccgcgagc acggcgcgca gggcggcccg gtcgcccgcg ccggcggtct ccggatcctc 25441 cggcccctcc ggcgccgggg tgcggccgag gagttcgatc cggcaccggg aggccgtcgc 25501 gagaacgccc acgcagtgcg cggtgatccc gcgagccccg ccgacgacga ccaccacgct 25561 gtcccggtcc aggcccaggg cggctgcctc ggccgcgccc tcgcccgcgg ggcccgcccc 25621 ggtgctgccg agcgcgccga gcggcgcggc ggtgagccgg ggcgcgaagc gcccggcgga 25681 ggtacgcagg acgacgggcg gggcggcgtc ggccaggagt tcggccgcca gcacctccgc 25741 cgcgccggcc ggcgacgcgt ccgcgcccag gtccaggccg acacagctca cgctcacgtc 25801 cgggtactca tgggcggcgg tccgcatcag cccgtccacc ccggcggacc ggaccccggc 25861 cgccgtacgg gccaggacca gccgacgcgg cccgcgccgc agggcgtccc gtacgaccgg 25921 gaagccggcc gggaggaacg gcgcgccctc ctccgcgagg gcggagagga ggacgacgcc 25981 gtccacggac ccgtccgcct cgctcagcgg gtggtcggcg gcgaggaggg ccgcttccgc 26041 gccgaggctg accagccggg cggacagctc cgccgccacc ccgcgcaacg cgccgtcgcc 26101 gtcgccgagc agcgcgtacc gcttgccggc gagcccgccc ggtccgggct ccggctccgg 26161 tccgggcagg gccacgggca gcatccggaa gcggcggggc gccgcgacga gcaggtccgc 26221 ctgcccttcc ggggctccgt ccggcgcggt caccggctcg ggggccgccg caggggcgtc 26281 cgccgaaccg ccgagggcgc gggccaccat ccagtgcgcg atcgccgagg cggtccgggc 26341 gcgggtcagc tcctccagct ccgcgtcctc cagggaggcc ggcgaggagc cgccggcagc 26401 gcccaggcgg cgggccagct caccggctat ctcggcccgc ttgatggagt cgacgctgag 26461 gtcggcctcc aggtcgaggt cgggctccac catgtccagg ggatagccgg tgcgctcgct 26521 gatcagctcc aggaccgcgc gcaggacccc ctcctcggtg aggaccgggg cgtcgacggg 26581 gccggcggcg ggcaccgggg cgggggcggt ggccggtggg gcggccggtg cggcgggaag 26641 gggcgccgcc gggagcggcg gcagcagcgc cggctggtac ggcggcgcag ggtgcccggc 26701 caggggcccg gcggccgggg cggccccgaa gtaggcgagc agcacgtcgc gttgagcgga 26761 gaccatgtcc cggctggtcc gcaggaactc ggcgatgagg gcgtccgccg caccgtccgg 26821 ggtctggccg gcatgcgtca caggggtctc cacgactcgt cgggccggcg cgagcgcgcc 26881 ggggaggggt tcgccggagg cggtgcggac gaggtgtccg tccacggtcc agccgggaag 26941 gcggggtgcg ggcgtccgct cggcgtcgat cgcgtcgcgg ccttggaaca tccaatccgt 27001 caccaccggc actccggcgg cggcgagtcg ggcgagcgcg tccaggaagc ccgggaggcc 27061 gctgtcggcc cgcggctcgc aggcgacgac gcggtgcggg cgctcgccca ggatgtcggc 27121 gacgaggcgg gtcaggacac ggccgggccc cacctcgacg aaggtgcgcg cgccggcctc 27181 gtacatcgcc tcgatctgcg ccacgaaacg caccggggag ccgatctggg ccgcgagttc 27241 gtcgcgtacg gcgtcgggat cggggctgta ggggcgggcg gtgcggttgg cccagacggg 27301 gaactccggt gcgcgcagcg gctgctgctc cagagtccgg cggaacgcgg gaccggcctc 27361 ggcgagcagc ggactgtgga aggcgcaggc gaccggcagc cgcgtcgcgc cgtggcccgc 27421 gtcgcgcagc agcttcagcg ccgcctcgac ggaggccgtc gggccggaga cgacgctctg 27481 ccggggagcg ttgtggttgg cgacgacgag cccccgtggc ggctgcccgt cgagcgcccg 27541 ctcgatctcc tcgggggtgg cggcgacggc ggccatcgcg ccgggatcgt cgccggccgc 27601 gccgaggacg gcccgggccc gcgcggcgct gaggccgggc agcgcgtccg ggtcgatgac 27661 gcccgcggcg cacagggcga ccagttcgcc gtagctgtgg ccggcggcca ggtccgggcg 27721 gacgccggag cgggtgagca ggccgtacgc ggcgagttcg acgatcccca gggcgggctg 27781 ggcggcccgg gtgtcggtca gggcctgccg ggcacgctcc cgcgcggcgt cgtcgaacgc 27841 ggcgggcggg tagagcgcct cgggcgcccg gccgtcgccg tcggccccca gcaggcggcc 27901 gagttcgggg aacgcggtga acaggtgcgc cgacatcccc gggcgctggc tgccctgccc 27961 cgggaacagg aaggcggtca gcccgggttc ggccgccggc cccgcgaggt gcaccccgtg 28021 cggcggaccg ccggccggcc ccgcgccggg ggcctggagg ccgggttcgg ccgtgccggt 28081 cgccccggac gggtcgggcg cgtcgagtgc gtcgagtgcg tccagggtgt gccggagccg 28141 tacgcacagc tcggccacat cgtgcgcgac gaaggcggcc tgtacggggc cctgggcgcg 28201 ccccgcgcgg tgcgaggccg tggcggccag atcacgcagc cgccaggggg cggcgcccga 28261 cccggccgcg gcggcgaggt cgagcagttc ggcggcggcg cggcgggccg ccgcgggccc 28321 ggcgccccgg aaggcgaaca gctcggcggg ccagctgtcc cgggcgtgga ccggcggcgg 28381 accgtcgccg ccgtgcgcgg agaggacgac gtggaagttg gtgccgccga agccgaacgc 28441 gctcagcccc gcgtgccgct gcccgggggc ggcgggccac ggcagcgcct cccggtggaa 28501 gacgaacggg ctctcgccct ccttccaggg cgagacgggc cgcttcaggt gcagtgtggg 28561 cgggcgtacg cccgtgtaca gcgcgagcgc ggtcttgatg aggccggcca gtccggcggc 28621 gcacttggtg tgcccgatct gcgacttcac cgaaccgagg acgcacgccc cgctggacgc 28681 gcccgcctcg gtgaacacct cggtgagcac accgagttcg gtacggtcgc cgacgacggt 28741 cccggtgccg tgggcctcca cgagcgagac ctgcgcgggg gagacgccgg cgttgcggta 28801 ggcgcgctcc agagcggcgc gctggccctc cggccgcggg gcggtcagcc cgagggaacg 28861 gccgtcgctg gaactgccga cccccttgat cacgccgtac acccggtccc cgtcgcgctc 28921 ggcgtccgcg aggcgcttga ggacgacgca cgcgacgccc tcgccgaggg cgatgccgtc 28981 ggcggtgtcg tcgaaggcgc gggagcggcc ggtgggggag agcgcgtgca cggaggtgaa 29041 cagggcgtag tcgttgatgc cgttgtggag gtcggcccct ccgcacagca tcagatcgct 29101 ggtccccatc accagttcct tgcaggcgac gtcgacggcg gccagcgacg aggcgcaggc 29161 ggcgtcgacg gtgtagttcg cgccccgcag gtcgaggcga ttggccaccc gtccggagac 29221 gacgttggcg agcatcccgg ggaaggtgtc ctcggtgagc cgcggcaact gctcgtccag 29281 ggcggcgggg acgtgtccgt agtaggaggg gagcacggcc cgcagggtgg cggcgttgga 29341 gaggtcgctg cccgcctcgg cgccgaagac gacaccggcc cgcgtacggt cgaagccccg 29401 gccctcctcc ccgtacccgg cgtcctccag ggcccgccgc gaggcttcca gggcgaggag 29461 ctgcacgggc tcgatgctgc ccagagaggt tggcgggatg ccgtagcgca gtgggtcgaa 29521 ggggatccgg gacaggaacc cgccccactt ggaggcgctg gccgcccccg gctcggcgga 29581 gtagtgcacg gccgggtccc agcgctccgg cggcacttcg gtgacggcgt cgtactggtc 29641 gaggacgtgc gcccagaagg aggccaggtc gggcgcctgc gggaacatgc aggccatgcc 29701 cacgatcgcc acgtccagcg gctcgggcgc acggtccttc gccgcgccgc ccgccgtacg 29761 ggccgctccg ggcgcgaggc gggggaggag gccggcggcg cggcggccga ggaagtcggc 29821 ggccccgtcg gtgacggagg cgtgcagctc ggccaccgtg gtggtcgccg agcgcagcac 29881 cgccacctcg cccgccatga acatcccctc ggcgtactgc cgggactcgt ccacggccgc 29941 gagaccgccg gcggcggtgc gctcgacgcc cttgctggcg atgcgcaggc ggccgacgtt 30001 gaggcgttcc agccgctccc agatctcgcg tcccgggacg ccctcggcgc gcagcccggc 30061 ctccaggtcg cggaagccgt cgctgaacgg gctggggacg cagcgggtgg cgtgtcccgg 30121 ggcggtgcgc agcagcgcgg tccgctcggc ggcgagcacc tgccgctgga agaggggctg 30181 tacggctccg cacgcgaccg cctcctcggt gaacaggtag gcggtgccca tcaggacgcc 30241 caccgcgcag ccgcgggcgg cgagcggggc ggcgagggcg gcgaccatgg ccgccgagcg 30301 cgcgtcgtgg acgccgccgg ccaggaacac ctcgacaccg gccgcgccgt ccggggcctg 30361 gtccgcccac gcgtcgatga cggccagttg ggcctcccag agcgggaagc tgttgcgcgg 30421 gccgacgtgt ccgccgcatt cggcgccctc gaagacgaac cgccgggcgc cctgctccag 30481 gtactggcgc agcaggccgg gcgagggcac gtgcaggaac gcccggatgc cgtcgtcctc 30541 cagggcccgg gcctgcgagg ggcggccccc ggcgatgatc acatgggtgg gccggtgggc 30601 gcgcacggcc tccagttggg cggtgcgggt ctcctcgggc gcgaagccga gcacgcccac 30661 gccccacgag cggccggcca gcgccgtgcc cgcctcggcg agcagggcgt gcgcctggtc 30721 gcgtccggcg agggccaggg ccaggaaggg cagggccccg ccgtcggcca ccgcgcgggc 30781 gaagtccgca ccgtcgctga cgcgggtcat ggggccctgg gcgatcggca gagcggtgcc 30841 cagagcgcgg ctcatggacg agtccgggcg caggatgtcc gcggcgccgt ccccctcgac 30901 ggcggccctg accgcgtcgg tgacggcgcg gacggcgccc gcggcgtcgc ggaagcggtc 30961 ggcgaaccgg gcggcgagga agccgtcctg gcccacgggc agcagccgct tctccgggtc 31021 ccggccgccg agcagggcgg ccacccgctc gccgtcgggg gagtcctcca ggggcgtcgc 31081 cccgggggcg cggcgttgca ggaaccggtg accggccagg acggtggtct cggagccgtc 31141 catcccgcgc aggacggcgg cgacggaggc ggggacggcg gattcggcca gcagcgcgag 31201 ctgggtgtcg agcaccacgc cggcggctcc gccgaccacg gcggcggcgg ccgagcccgg 31261 tgccatgcct ccgcaggccc acaccggcgg gccgtcgggg ccgaccgcgt cgaggagttg 31321 ctggagcagg acgaacgtcc cgagctcgcc gatccgcccg ccgcactcgc tgccgcgggc 31381 gatgaggccg tggacgccgg cgtcgagggc cgcgtgggcc tcgtccggac cggtcacctc 31441 ggccaggacg cggacgcccc ggggcagggc tccggcccgc cagggagctc cggcgccgag 31501 caccacggtg tgcggaagtc cctcgtcgcg gacgaggtcg tcgaggacta atcggcactg 31561 cggcccgaca cggaccccgt ggcggccggg gagccacctg cgcaggtcgt cccacgccgc 31621 acgggccgcg cggtccccgg aaccgaggtc caggaccccg agtccgccgc cgcgtgtgac 31681 ggccgccgcc agccgggcgt cgggttcgcc gaagggagtc aatccgatga ccaggtcagg 31741 gatgttctct gccgatgtca tatttctccg aatgtgcgat gcattgccgc tgggggattt 31801 cggccaagca aaagccgcag aaaggcacgc ggtcacgcgg acccggaaca ggaattccgg 31861 ccgtccggtg aacgaggcga aactagcggc aaggtagtga agggtcaacg ctgcgtcgcg 31921 ggttcgcacg cgaaacttga gcggtgtcag gggtcgcgcc gaagggcggg acattctggt 31981 aggcggtgtt cgccgcgcca cacgtcgtgg agtgtgaaag gccggaattc gacgccttgg 32041 agaggctcaa gagcgccgac agtactggcc agtaggggta ttgtcaggag cgccgccgct 32101 ccgactgctc ccggttctgt ccggttccgg cgttgcgcga cgccgctctt gcgcccacgg 32161 gcggtgtcgg cgtacgccgt acgggccccg tttcccgtgc cgccgcaggg gtcggccggc 32221 cggatcgtcg cgggtggcct ccgcctcgga agtggcgtac tccacaccct cgaacagggg 32281 cgttcgaccg cccggcgccg gcgcgggccc cgatgcggct ccccggaggg ccgccgcgcg 32341 ccccggcttc gcgtggcccg tgtccggtcc cggacgcggg ttggacgcgg cggcggaggg 32401 tggggcgggg ccgtgacgcc gttgcgcgtc acttgaagtg ctcatgctca atgagcagtt 32461 gggtctcgcg aaggctccgt cggagcggag tgcgcggggg tgtccgccgg cccgcccggc 32521 cgcctccgcc cgcagggatg ccccatggcc gccgcggtcc gccgcccgcc ggagaggggg 32581 tgtggggcgg gcgcattcga gatgtgggcc ccaccgcatg tttcccgctg gtaacttgcc 32641 ttttcccatc ctccggattt ccgccccggg cgggtccccg aacgaaagga ataacgtggg 32701 cacaaagatg tcgaaacgcc ggtcagccgt cttcgcattg gccgtcctgg tcgccggaac 32761 cgtggcggcg gccccgccgg ccggcgcacg cgcacaggct gggaaatgct caccgatcgg 32821 caccgccgga gcccccgacc tgccggccgg cggaaccgac ggattcgagg acctgcgacc 32881 cgccccggcc gacacacaat tacccgatca agttcacctc agggacacac ggggcacctt 32941 caaccgtgtg tggtcgttcg ccctggcgga cggcagcgtg tacaccaagc cggccgggct 33001 gagcggcggt tggcgcgtcg cccccgttcc ggactgcctc gacgggcgga tcaccgggat 33061 ctccgccgac gacgacgaac tcgtcgccgt cgacggcgaa ggccgggtct tcaccatgga 33121 ccacgccatg aacgagcccc gcctgtggaa ctggaccagc aggttcggcc cgcccatctg 33181 gctgggcagc ggcaccacgc tgccggacgc gacggtggac tggtcctggt cggtgatctc 33241 gccggccgag gacgtgcgct ggaccgacgc catcggcaag ccgcacgaga tcgagcccgc 33301 caaggtcagc cacgtctacg cgctctcggg cgacggaagc cggatcacct acctggaccc 33361 ctggctgccg agcgaccaca gctacgagct ccgcaccccg ctgggcgggc gcttccaggc 33421 ggcgagactg tcggccagcg gctccaccgt gttcgtgacc aaccgctacg gcgacctgta 33481 cacccggctc tacgacttcg acatgtccgg cggcaactcc gtcttcttcc gctactccta 33541 cgaggaccag agcggcctgc ccaccgcgcc gaacctgctc ctggagcgca tcgacccccg 33601 ttacgccgcc gtgcagctcc ccgcacagga ctgggtccgc cagccgaagg tgcccggcga 33661 gatgaccgac cgcatctcca tccacaagac cggcccccgc ccggacgcca gagagctgcg 33721 cgtggagggc gtgaaggacg gagcgacggg cctctggcgc aaggagatcc gcgcctccgc 33781 ctggtccttc acccccaccg ggcagccctt gcggggccga aagctcgaca acacgcccga 33841 ggaccgttcg acggacaccc tggccccgcc gtcgccccac tcgtacgcgg ggaacggcga 33901 cggctacagc gccgaggcgc ccggcttccg cacggccacc ggcgcgacgc cgctgaatct 33961 ccggttccgg agcggggcca cactgaagct gaccctgcag acggtggacc cgctgcggca 34021 gttctcccgt gccgacggcc tggacgacaa gccccgcgcg tacaacggcg cggtggaagt 34081 gccccaggaa ctgctggaca acctctccca gcagcccccg gaggtccgcg acttcgtgac 34141 cgacaccctg ggcgcccgac gcttcacgac gaccggcgtc gacgccagca cccgctcgct 34201 gcggatcgcc gccctcggcc tgaacctcgc cgcccgatag caccggcccg acacccccgc 34261 accgcgaccg ccccgaccgg ggccgggccg ggcccgcacg acggggcccg gcccgaccgg 34321 tgaggacggt gcgccgtcac gtacggcggt cgcggtgcgg ggtggggtgc cccgcgccct 34381 gtcccgaagg tcctcgacga cgcgcggctg tgtacttcgg acgcccgctg ccgccacgat 34441 cgggccaggt agtctcggac gcatcgtcat cgcggcccga cgggcttccg ctccgctccg 34501 gtggagtctc gaaggacacg cccccacccg cacgagtcac ttcgtgctgc ctgggggaag 34561 accttgttgt tccgtgcatc agccaagtcc gtggcggctg cggcgatgga cagctcgctg 34621 ttcctgcatc tcaccgagca gttctttcac atgcacggct accggcccac ggcctccgag 34681 agccgctcct gggaacgcag catcccggcg ctcatggacg tcctgaacga ggcggggctc 34741 ggggacgtcg aggtcatgct cgagtacgcg ctgccgctca acagcaagcg cgcggacgcc 34801 gtcctggcag gcgtgcaccc ggtgaccggc gagccgtcgt atgtcgtggt ggagctcaag 34861 cagtggagtc aggcggagcc ggaggaggac gaccccgccc tgtgccgcgt cgacagctat 34921 acgcatcccg tgctcacccc ggtcgagcag gtgcgcaggt actgcgagta cctcgtgaac 34981 ttcaacgggg ccctcgccgc ccatcccggt cggatcaacg gagtggccta cctccacaac 35041 gccgccgaat ccggcgtcgc cgcgctgcgt gagctcgcat tcgacgaaca cggaacgctg 35101 ttcacggccg agcgccgagg agcactcctc gaccatctgc gcaccaggct gagcaccgaa 35161 cacgccggcg cgtccgccgc cgacgaactt cttcggggaa ggcccgtccc ttccaggcaa 35221 ctgatggccg tcgccgccga cgaggtccgt gaccgtgagc agttcgttct gctcgaccag 35281 cagcaggtcg cctaccgcat ggtgctcaat gccgtcagcc gggccaaacg gtccgatcac 35341 aaggaggtcg tgatcgtcac ggggggaccc ggcacgggca agagcgtcat cgctctgtcc 35401 ttgctcggcg aactcttccg tcggggcgtc cccgctctgc acgccaccgg ttcccagtcc 35461 ttcacgaaga cgatgcgcaa ggtcgcggga gcgcgaaggc gtgaggtgca ggacctcttc 35521 aagtacttca acagcttcat gaccgcagag aagaacgctc tcgacgtcct gatctgcgac 35581 gaggcccacc gaatccgcga aacatccgcc aaccgctaca ccgctgccgt gcaccgcacc 35641 ggcaagcggc agatggagga actgatcgac gtcgcccgcg tgccggtctt cctcctcgac 35701 gagcatcagg tggtgcggcc cggagagatg ggcacggtgg ccgagatcga ggccgccgcc 35761 gcgaagaagg gactcgcgtg ccgtgtggtg ccgctcgaca gccagttccg ctgcggtggc 35821 agcggcgcct acctccgctg ggtcgtacga ctcctgggtc tcgagccggg aggtccggtc 35881 gtgtgggacc ccgacgaccg catgcggctc atggtcgctg acagtccgcg ggagatggaa 35941 gcgttcctgg aagggcgctt tgcccagggc tatggcgcgc ggctgtccgc aggctactgc 36001 tggccatggt cgaaggagcc caaaccgggt gacccgctcg tggcggacat cgtcatcggc 36061 gactgggccc gtccctggaa cctgagaggc gagcggtccg tctccggtgc gcccccgtcg 36121 gctctgtggg ctaccgaccc ggctggtttc ggccaggtgg ggtgcgtcta cacggcgcag 36181 ggcttcgagt acgactggtc gggagtgatc atcgggccgg atctgatctg gcgtggagac 36241 aggtggatca ccgatcgtgc gtcatccgag gatcccgtct tcaagaaggc cccgtcgggc 36301 gcggatgtcg accgcctgat ccgcaacacc tacaaggtct tgctgaccag aggaatgatc 36361 gggaccgtcg tctactccac cgatccggag acgcggcaga agctgcggga actggtgggg 36421 gcgacgcggg cgatcgtcac ggtctgacac cgcaaggcga cggagcggag cgcgggccgt 36481 cccgaagacg gcgtcggcac gactgtcacg gaccggcgag gtgcgcgcgt acgtgatgac 36541 agccctttgg cgggcggttg agagaccgag aggttcgccg cctatcctcc tgttgtgcag 36601 ttgcctcagg atccatcgaa cgtcgcccat gccctgttgg cggcctttcc gacccgtctc 36661 gccgatgatg tgcggaaagt tctggcggtc atgccggagc cccggatcgc accaatgatg 36721 cccttccagg tcgaggtgca gggagagacc ttcgccatcc cgtcgcgcat ttacaacgag 36781 gaaccgggcg ccgacgtgga gtgggacccg accggaaccc gccaggtgat tctgcactgc 36841 ctgtactccc ggcaccacga gggccatgtt cgccaacggc acctcgagca gcttgtggcg 36901 tcgggggagc cgtgggtggt cccgttcgtg gtgcagttgg ccggggaata tgtgctggag 36961 atccttgagg cgatcggccg gggccttccc gggctcgcga tccctggatc ggcccagcgc 37021 cgactctacg gagagttcat cgctcggaat ccagccttct tcgcgcgcac ggagcggcgc 37081 gtggtgagct actggtcctg ctactaccgc tggaagtacg gaacattcgg gacgtatccc 37141 ggatgcgtcc tgttggaagc gttccgcgct gctgtagtgg aacaggtggg cgcggagtgg 37201 ccgcggcaca cgccgccccc gctggcgaac gagagtgggg tacctgcctg aggtcgccca 37261 ccacgaccag gtgggcgtcg gcatcgatga cgagtcggtg atcggtggag cgcctcgcgg 37321 tcagcaagtc gctgaggcgg cgtgggctcg gtccggtgaa caggacatat ccatgtcgac 37381 taagacgccg tgaccacacc agccaggcca agatcatttc acccatgacc agtagttgtg 37441 ggacagccct taggatcgcc gtaccggttg cggcccgacg ggcttcccct gtggacatgc 37501 ccccacccgc acgagtcact cgtgccctgg ggaaaccacc ttgtccatgc tgctgctgcg 37561 gttgtcggcg aaagacctgc tcactctcga ttcacggcgc cgcatggtgc ctcacctggc 37621 cgcccgatgg gtgcacttcc gaggagagaa agcctcgctc ggtgaacgca cggcctgggc 37681 ggaaagcctc atcgagttgg cgagggacct ggtggccgcc gaccgcggca acgtggagat 37741 gatcgtcgag tgctcggcaa ccgtcgacga cccggaacgt tcggaccgga gtcgtcagat 37801 cgacgtggtc ctggcggggc gccacccggc ggacggcgac atctccgtcc agctcgtgga 37861 actgaaacgc tggtcgaccg tcacccgcgt ggagaaggcg accgccgacc tggtacacat 37921 tccgggaatc gacgacgtga agaggcatcc ggctctccaa ctgcgcgaat actatgaact 37981 cttcacgggc gccactggcc cactgcacgg cctgcggttc gaatgcggtg gattcaccta 38041 cctccacaac gccacggatg agtccgtacg acccctgctg ggcatcgacg ctccgaccgg 38101 ttcctatgcc cgcacctaca ccaaggacag caggaacaag ctccaggaag acctccgcca 38161 gcacttcacg gcggacgagc atccttccgc tgcggagatc ctgctgagcc gtatgaatct 38221 gcggaacacc ccgttgctcg acgccatgat caaatccaac ggcgaagaca cggtcttcac 38281 tctgcggggc cgtcagaaga gggtcgcgga cgacgtgctc gaggccgcag tgcacgtact 38341 ggacgaccct gcggcggacg ctctcgttca gaatccgcgc cgtgccgtct ttctcgtcac 38401 gggtggcgcg ggaacgggca agagcgctat cggcctccag ctcaaggccg agttcgaggc 38461 agccggtcgt acggtgatgt acgcgagcgg atcgcgagcc ttcaatggag cgatgcagga 38521 gcatgtgggg tacggagacc gtgagttcaa agagagcttc acctacttca gcaacttcgt 38581 cacccctcct gaagaaccgc tcgacgtact gatctgcgac gaggcgcacc ggctgagaga 38641 gcgttcgttc aaccggttct gggcttccga gaaacaaggg acgaaagctc agatcgacga 38701 gttgctggac gcgtcacggc tgacggtgtt ccttctggac gagagccagt ccttgcgccc 38761 caatgaggtg ggcaccgtgg acgtgatcaa ggatgcggcc ggccgccggg gggtggtggc 38821 gcgctcctac catctccagg agcagtaccg gtgcggaggg agcgacgcct acatccgctg 38881 ggtgcgtgac cttctgggtc tctcgggtgg acggccgggt ctctggacgc ccgacggcct 38941 gatgcacatc gaggtggtgg acaccccgga cgaactggag gacattctcc gcaccgagtt 39001 cgattccggg gcgtccgccc ggatggtagc cgggttctgc tggccctgga gccctcccga 39061 cgaggcgagg aagcttgtcg ccgacgttcg tatcggcgac tggcaccgcc cgtggaacgc 39121 gtcgagcgag tccttctgcg cggggggcga accgccgtcg aaaatctggt cggtgcatga 39181 tgccggcttc ggtcagatcg gctgcatcta cacggcgcag ggactcgaat gggactggtg 39241 cggagtgatc atgggcgacg acatggtctg gcgcaccgac aaatgggtgt tccggcgagg 39301 caagaagcgc aaggacaagg acaccggaac gcagcacgtc atcgagcccg gatccctcga 39361 cacggaggtg tgcaggaaga ccgggaccga cgacgaggcg ttcgcccgct gtatccgcaa 39421 cgcctatcac gtactgctga cccgtgccag ccgcgcgacg gttctctatt ccagtgacaa 39481 ggagacgcgg gactatctca ggtcgctggt gggcgatatc gagatccacg gtctccgccc 39541 gacctgggaa agccttccgc ccgaggcccg ggtgccgcac caagcgcgcc cggcgagggg 39601 aagcaggtcg cgcaacgccc ggaggaagaa ggccaagcag ctcaaggaga aagacgagtt 39661 gaagctgttc tgaccggttg aggagtgggg tggcgggctc tccgggcccg ccacccgcct 39721 gcttcagaag agcaggtgcg ctgccgccgc cacggccgcc accacgagat tggcgacgac 39781 accgacggcg acgtccatca ggaccttgcg gaaccagatg cgacgcgcag acgtgtactc 39841 gacagggttc atacgggacc actcctcggc ggtgagcagg aatggtgggg gacagcccac 39901 cgggcatccg ctcacacacc gcgtgaaacc atgcggtgat acaccagcca ttactcacat 39961 gccgcggaac ggcgcatgaa ctctgtacgc gtaccctccg ggaaggtgcg cagcgccgga 40021 aagcctaccc gacgcacgag ctgtcgcacc cgagtgcagg agcacggccc ttctgccgta 40081 cgcgcgtgaa ccgtccgccc gcaactctcg ccacgcagcc ccctccccgc cacgccccca 40141 ggccagttcg cgcagtgcgt gctgccgcca gtgctgcgtc ttcttcccta tggcctccac 40201 gcggtccccg gcaggctgct ggaaaacacc gcttggaggc tcacagtgac agcaggcgcg 40261 gcccccgaag gggctcggaa cggcggcgac acccttacgg catccttcgc gcagcggcgg 40321 ctgtggttcc tggatcagct cgccggcacc tccgccggct cgatgctgcc cctcgtcctg 40381 cgcatcaccg gcccgctcga cgaggcgcgc ctcgcgcggg ccctggacgg gatcgtggcg 40441 cggcacgagg tgctgcgcac ccggttcgcg gcggtcggcg gcgagcccgt gccggtcgtc 40501 gacccgcccg gcgggatcgc cctggagcgg gtcgaggccg aggggcccgc cgacctcttc 40561 gcgcgctgcc tcgggcggcc cgtcgacctc tccgtccagc atcccgtgcg ggccgccctc 40621 gcccgggtgg cgcccgacga gcaccttctg ctcgtcgagg tgcaccacat cgccgtcgac 40681 ggctggtcgt ggggcgtgct gctggaggaa ctggccgccg gctaccgggg cgagagcccc 40741 gccccgcccg ccacgcggta cgccgacctc gccgaagccc agaccgcgcg gctctccggg 40801 gcgcggatgg agcggctgct cgcctactgg cgcgaacggc tcgccggcct ggccccgctg 40861 gacctgcccg gcgaccggcc ccggccccgc gtgtgggacg gctccggcga cgtcgtccgc 40921 ttcaccctgc ccgccgacct cgtcgccggc gtcgacagcc tcgcccgcgg ccaccgcgcc 40981 acccggtaca tgctgctgct caccgtctac caggccctcc tcggccactg gaccggccgc 41041 accgacgtcg ccgtgtgcag caccatggcc gaccgcgccg gcgcgggggc cgcgaacgtc 41101 gtcggtccgc tggtcaacac cgtcgtcctg cgcaccgacc tctccggcgg gcccggcttc 41161 ggcgagctgc tggagcgggt gcgcacccgc gtccttcagg acctctcgca cgccgaagcg 41221 cccttcgagc gcgtggtggg agccgtcggc ggggagcgcg acctgtcccg ccatccgctg 41281 gcccaggcgt cgttcacgct gctcaactcc gcgctcaagc cggtgcggat gccgggcctg 41341 gacgtggagc tggtgcctcc gccgctcgcc gagacgcacc tggacgtctt cctcgacctg 41401 accctgcgga ccgacggcgg catcgccgcc atcctccagt acgccaccgc cctgttcgac 41461 cccgccacga tgcgggcctt cgccgacgcc tacaccgcgc tgctgcgggc cgtcgtcgcc 41521 gacccccgca ccccggtacg ggacctgctg cgcgccctgc ccgccaccgc cgcccgtacg 41581 ccggccctgc cgcgcgccga gtggagccgg tcgcccgacg tcccggccgt ccccgaccgc 41641 ccgctcggct tccgcggcga gcccggggcg accgcgctga tctgcggcga cgacagcgtc 41701 acgtacgccg gcctggacgg catgaccggc ggactggccc gtgccctggt cgacgccggg 41761 gccgggcccg gcagtccggt cggggtgctg ctgcggcgcg ggctctggtc ggtcgccgcc 41821 atcgagggcg tctggcgggc cggtggggcc tacgtaccgc tcgatcccga actgcccgcc 41881 gagcggctgc ggttcatggc ccaggaggcc ggtctggcct gtgtcgtcgc cgacgccgcc 41941 accgccgagg acgccgccgc gctggccccc gtgaccgtcc gcgtcgacat ggtcgccccc 42001 tcggcccacg gcccccggca cctccccgac ccgcgcgaac tggcccacgt catcttcacg 42061 tccggctcca ccgggcggcc gaaggccgtc ggcgtcgagc acgccgcgct cgcctcccat 42121 gtggcggcgt tccggcaccg gctcggcatc accgccgacg accgggtcct cgcgttcgcc 42181 tcgttctcct tcgacgcctc cctcgaccag gtcctgcccg cgctcacctc gggcgccacc 42241 gtcgtcgtcc gcccggacga gccgtggctg ccgacccgcg tccccgaagt cgtacggcag 42301 cacggcctca ccgtcgtcaa cgtcccgccc acctactggt ccgagctcac gctctcgctc 42361 ggccgccgcg aggcgtccgc cctcgcctcg ctgcgcctgc tcgtcctcgg cggcgaggcc 42421 gtgcccgccg acaccctcgc cgcctggcac gccgccgtgc ccggggtgcg ggtctgcaac 42481 gcctacgggc ccaccgagac gaccgtcacg gccaccaccc acgagaccga cggcccgccc 42541 ggcgggaccg tgccgatcgg gcggcccctg ggcggacggc gggtccacgt cgtcgacccg 42601 gacggcgaac cggtccccgt cggcgtgagc ggcgaactcc tcatcggcgg cacggaggtg 42661 gcgcgcggct acctccgcag gcccgccctg acggcggagc gcttcacccc cgacccggcc 42721 ggtccgcccg gcagccgcct ctaccgcacc ggcgacctgg tccgctggac gcccgccgga 42781 gagctggagt tcctcggccg ccgcgacgac caggtcaaga tccggggctt ccggatcgaa 42841 ctcggcgagg tcgagtcggt gctgcgcgcc tgccccgacg tcgccgccgc ggccgtacgg 42901 ccggaccggg ccaccggacg caccctcgtc ggctacgtgg tgcccgccgc acccgccggg 42961 gaagccgggc aggacaccgg cgcgggcgtc gagcgcgtcg ccctgcgcgc ctggtgcgca 43021 cgccagttgc cgcactacgc cgtcccctcc gagttcgtcg tcctggacgc gctgccggtc 43081 ggcgtcgggg gcaagctcga ccgctccgcg ctgcccgacc ccgcccacgc ccgctccggc 43141 tccgccaccg gctacgtggc gccgcgcgac gacaccgagc ggaccgtcgc cgacatctgg 43201 gccgacgtcc tcggcctgga gcggatcggc atcgacgaca gcttcttcga cctgggcggc 43261 cactcgctgc tcgccacgat ggccgtctcc cgggtcgccc agcacctggg acgcgacatc 43321 gagctgcgca ccgtcttcga gaaccccacc gtgcgcacct tcgccccgcg cgtcgccgcc 43381 gcccgcccct ccgccggagc cgacgcggtg gtccccgccg accggacgaa gccgctcccg 43441 ctgtccttcg cccaggaacg gctgtggttc ctggaccgca cctccgaccg gggcgacgcc 43501 tacctgctcc actacggctg gcggctgcgc ggcggcctgg accgcaccgc ctggcagcac 43561 gccctcgacg acctcgtcga gcggcacgag gtgctgcgca ccgcgctcgt cgagtccgac 43621 ggccggcccg tgcagcgggt ccgcgacgcc gtccccgtac cgctgcactg ggagcgggcc 43681 cccgacggcc cgagcgagcg ggagcgtctg gacgccgtac gcgaacgggc cgccgccctc 43741 gccacccgcc gcttcgacct gacccggacg ccgctgctgc gcgccggagt gtgggagctg 43801 gccgaggacg accacgtggc cgtcgtcgcc ctgcaccacg ccgtcaccga cggctggtcc 43861 aagggcgtgc tcgtcgacga gctggcccag cactaccggg cccgccgcga gggacgccgg 43921 gccgtgctgc cgccgctgga ggtgcagtac gccgactacg ccgtgtggca gcgcgaccgc 43981 gccgacagcg gagccctgga accgcaactc gcctactggg aggagacgtt ggacggcgcg 44041 gcggccctgg agctgcccac cgaccggtcg cggcccgcgg cgttcagcgg ccggggcggc 44101 gcggtcgagg tcgagctgcc cgccggactg gccgaccggg tcgacgcctt cgcccgtgag 44161 cggggagcca cccgcttcat ggtgctgctc gccgcggcgc agctcgtgct gtcccgctgg 44221 tcggggcaga gcgacgtgtg cgtgggcact ccggtcgccg gtcgcggccg ggtcgaactg 44281 gagccgctcg tcggcttctt cgtcaacacg gtcgtgctgc gcaccgacct ctccggccgc 44341 cccggcttcg cccgcctcct ggaccgggtg cgcgacggcg tcctcggcgc cttcgaccac 44401 caggaggtgc cgttcgagcg ggtcgtcgag cggttgcgcc cgccgcgcga cctctcgcgc 44461 aacccgttgt tccaggtcat ggtcgacgta caggactccc cggcggccgg gcccgccgtg 44521 cccggactgc gcgccgacgg cttcgccctg ccgtggggtt cggcgaagtt cgacctgacg 44581 gccacgttcc tggtcgctcc cggacggttc gccctcaacg tcgagtacgc ggccgacctg 44641 ttcgacccgg ggacggccac ccggttcgcc cgccacgtcg gacgggtgct gcgggccgtc 44701 ctggacgagc cgggccgccc ggtggacgag gccgctatga cgtccgccga ggagtacgcg 44761 cacctgctgg cgaccgccgg ctccgcgacc gccggctccg cgaccgggga gagcgccccc 44821 gcgccgggga ccgcgccgag gttcgcggtg agcggacgcc ccgccgacac cgccgtcgtg 44881 tgcgagggcg aggcggtcga ccacgccggg ctggacgccc tgaccggcgg actggcccgc 44941 ctgctggccg actccggcgc ggcgccccgg gacgcggtcg gcgtatgcct cgggcgcggc 45001 gtccggtcgg tggccgcgat gctcgccgtg tggcgggccg gcggcgtcta cgtcccgctg 45061 gacccccgcc tgcccgccga acggctcagg ttcatgctgg cggaggccgg ggtgcggtac 45121 gtcgtcaccg acgccgcctc ccacgacctg gtgtccgggc tgggcgcggt cacggtcccc 45181 gtcgagcggg cggcgccgga ccccgacggg ccccggcaca cccccgcgcc cggcgatctc 45241 gcctacgtca tcttcacctc cggctccacc ggcctgccca aggcggtcgg cgtggagcac 45301 cacgcgctcg acgcccatgc ggccaccgcc cgcgagcagt tcgccctcac ccgggacgac 45361 cgggtgctga ccttcgcctc cacctcgttc gacgcctcgc tggagcagat cctgcccgcg 45421 ctcggcgccg gggcggcggt cgtggtgcgg cccgacgaca tctggtccgt ggacgaactg 45481 gccgcccgcg tcgccgccga gggcgtgacc gtcatggaac tcaccccgtc ctactgggag 45541 gaggtcgtcg cccgcctgga caccctcgcg ccccggctgg ccggactgcg cctgctggtc 45601 accggcggcg aggcgctgcc cgccgacccg ctggagcgct ggttcgcgca cctgcccggc 45661 gtaccggtcc tcaacaccta cggcccgacc gaggcggtcg tctccgccac cgcccaccgc 45721 gtcgaacggg ccccggacgg gcacagagtg cccatcggca ggccgctcgg cggccggcgc 45781 gcctacgtgg tcgacgcgcg cgacgccctc gtaccggaag gcgtgcccgg cgaactcctg 45841 ctgggcgggc cggaactggc gcgcggctac ctcgggcggc cggcgctgac ggcggagcgc 45901 ttcgtccccg acccgttcgg gccgcccggc ggcaggctct accgcaccgg cgacgtcgta 45961 cgccgactgc cctccggcga gaccgagttc ctcggccgca acgacaccca ggccaagatc 46021 cgcggcttcc gggtcgaacc cggcgaggcg gaggccgtgc tgcgccgcca cccgggcgtg 46081 cgggccgccg ccgtgaccgt ccgcaccctg cacggcgacc cggcgctcgt cgcctacgcg 46141 gccggcgacg ccctccaggc cgacgccctg gaagcccact gccgcgccca cctgccccac 46201 tacctcgtcc cgtccgcctt cgtcctcctc gacgccctgc cgctcaccgt gcagggcaag 46261 ctggacaccg ccgccctgcc cgccccggac gctcccgcgc ccgtcgcctt cgtcgggccg 46321 cgcacccccg cggagagcgt cgtcgcgcag atctgggccg aggtgctgga cctgccgcgg 46381 gtcggcgtgc acgacgactt cttcgccctc ggcggccact ccctgcgggc cgtctccgtc 46441 gcctcccgcc tgcggaccgc cttcgactgc cccgtacagg tccgcgacct gttcgagcac 46501 ccgaccgtcg cgctgctcgc cgccgacgtg gagcgccgtc tgctggcgct gatctccgag 46561 atgtccgacg acgagatcgc cctgtccctg actgccgacc tctgagcccg gggtcaccac 46621 cgcacaccct tccctgactt ctccccagcg agaggacgga gttccccatg accacttccg 46681 acgtgcgtcc cgggcccctg gccccgaacg gcgaccagcc ccccgcccgc ggcgacggcg 46741 gcctgtcgcc cgctgcccgg cggctgctcc agcagcggct gagcggtgtc gccgcggcca 46801 cggccgacgg cccggtccgg gcggccgagc ggcccgagcg gctgccgctg tccgccgccc 46861 agcgccgcct gtacttcctc gaccggctcg accccggcgc cgcgacctat ctgctgcccg 46921 ccgcctggcg gctggccggg ccgctggacg tgccggccct gcgcgccgcc gtcgccggcc 46981 tcaccgcccg ccacgagcag ctgcgcgtgg tcttccccga gcacgacggg acgccccacc 47041 agcgcgtgct gcccgccggg gacgacgtcc tggacgtggt ggacctgacc ggccccgccg 47101 acggcgaccg cgaagcgctc ctggccgccg ccgtgcggag cgccgccacg cgccccttcg 47161 acctggcccg ccggcccgcc ttccgggcca ccctggtgcg cgccgccgac gacgaccacg 47221 tcctcgtcct cgccatgcac cacatcgtct ccgacgggtg gtccctcggc ctcctcgtcc 47281 gcgacctcgg cgagctgtac gcggcccgca ccgccggccg cgtagcggac cttcccgaac 47341 tgcccctgga ctacaccgac tacgccctgt ggcaggaccg tgccgaccac acggcggagc 47401 tggcgcactg gcgtacgcgg ctggaggggc tgacgcccct ggagctgccc gccgaccacc 47461 cccgcccgga cgccccgggc ggcgacgggg ccgcgcacac cctcaccctg ccggccgcgc 47521 tcgccgacga actggccgaa ctgggccgcc gcacgggcgc caccgcgtac atgatcgtgc 47581 tggccgcgtt ccaggccgcg ctcgccttcc gcagcggaca ggacgacatc gcggtgggca 47641 ccgtcgtcgc caaccgggag cgcccggaga tcgagcagct ggtcggcttc ttcgtcaaca 47701 ccctcgtgct ccgcgccgac ctgtccgacg accccacgcc cgcggccttc ctggcccgca 47761 ccagggagag cgccctggac gccttctccc accagacgct gcccttcgag caggtcgtcg 47821 acgcgctcag cccggagcgg gacctcgccc gcaacccgct ggtccaggtc ctgttcacgc 47881 actcctccgc cgaaccgggc ggcctcgccc tcggcggtgt gcacggcgtc ccgtaccgga 47941 tcgacctcac caccgcgaag ttcgacctgg cgctcgaact ccgcgacggc cacggccccg 48001 ccgagctggt cttcgtctac cgctcggacc tctacgacgc cgcgtccgtc agctccctcg 48061 cccagcacac cgtgacgttc ctggaagcgt tctgccgcac ccccgacacc ccgctcggca 48121 gcatcgaccc gctgaccgcc gaggaacgcg ccggactgct gggccccgac ggaccggcca 48181 acgccgggcc cccggccgca cccgccccgc gtaccgcgcc cgagcgcctg gccgagcaca 48241 tcgcccgcac cccgcacgcc gccgccgtca gcggctccgg ccgcaccctg acctacgccg 48301 aactcgacgc ggcggcctcg gcgctggccc gccggatgcg cgcggccggg gtcgcgccgg 48361 gctcgctcgt cggcgtctgc ctggagcgct cgcccgacct ggccgtcgcg ctgctcgccg 48421 tctggcggac cggcgcgggc taccttccgc tggacccggc ccacccgcac gcccgccgcg 48481 cgttcaccgt cgcggacgcc ggcatcgact ggatcgtggc cgacgcggcc tcccgggcgg 48541 cggccgaggc gctgcccgcg ggcgtcatcc cgctggaggc cgacgacgac gcactgcggg 48601 cgcgggacga ggccggggcg ggcggtgacc tccgcccggc cccggacgac ctcgcctacg 48661 tcatctacac ctccggttcc accggacggc ccaagggcgt cgaaatcacc cacgccaacc 48721 tcgcctggct gctggacgcc gccgaccgcc acttcgactt cggcccgtcg gacgtgtgga 48781 cgcaggtgca ctccccggcc ttcgacttct ccgtctggga gctgtggacg ccgctcacca 48841 gcggcggacg cgtcgtcgtg ctggacgccg accaggtgcg cgacccggcc gccgtgcacc 48901 gggtgctgcg cgaggagggc gtcaccgtcc tcaaccagac gcccgccgcc ttcaagggcc 48961 tgcgcgccca ggtggccggc ggcgaagccg gcttcgcgga cctgcccctg cggacggtgg 49021 tcttcggcgg cgacgcgttc gacgtacggg actaccgcga ctggttcgcc gcccccggcc 49081 ccaagcccga cctggtcaac atgtacggca tcacggagac caccgtgcac gtcaccttcg 49141 gccgcgtcac cgaggacgac gtgcgcggaa cggtccgctc gcccatcggc cgcccgctga 49201 ccggccagca cggctacgtc ctggacgccc ggggccgcct ggtcccaccg ggcagcaccg 49261 gcgagctgta cgtctccggc ggcggcgtcg cccgcggcta ccgcaaccgg ccggagctga 49321 ccgccgagcg cttcctcgac gacccgttcg gtgcgccggg cggccggatg taccgcaccg 49381 gagacctggt ccgggtcgag cgggacggcc ggctcggcta cgtcggccgc gccgaccacc 49441 aggtcaagat ccggggctac cgcatcgagc ccggcgagat cgagaccgtg ctgcgcgccc 49501 tgtccggcgt cgccgacgcc gccgtcgtcg cccgcccgga acgcgacggc gcgcgtctgg 49561 tcgcccacgt cgtcaccacc gagggccgcc cgctggacgc cccggcgctg cgcgagggcc 49621 tgcggctcca gctgcccgac cacatggtgc ccgccctctt cgtacgccac ccccggctgc 49681 cgctcaccgc caacggcaag gtcgaccgcg ccgccctgac cgccatcacc ccggccgcgg 49741 cggcccgcgg cgggcacgta ccgcccgagg ggccggtgga gagcgtcctc gccggcgtct 49801 gggcgcaggt gctcggagcc gaacacgtgg gccgcaccga caacttcttc gacctgggcg 49861 gcgactcgat cctggcgctg cgcgtggtcg gcctggcccg gcagggcggc ctcgccctca 49921 ccatcgccga cgtcttccgc gcccgcaccc tggccgacct cgccggggcc gcgaccgagg 49981 cgcgcgaggc ccccgagccc gtcgcgccct tcacgcagct ggaccccgcc gacgccgacc 50041 ggctgccgga gggcctggag gacgcctacc ccctgaccat gctccaggcg ggcatgctgc 50101 acgaaatgct cgccgacccg ctgcacggcg cgtaccacaa cgtgaccgac ctcaagatca 50161 ccgtcccgga gggcttcgac cgtgcggcgt tccaggccgc tgtggacgcg gccgtcgccg 50221 ggcacggcat cctgcgcacc tccgtcgacc tcgtctccta ccgcgaaccg ctgcaactcg 50281 tccaccgcgg cgcccacctg cccgtcggct acaccgacct gcgcggcctg ccccgcgagg 50341 accagcgggc ccggctgcgc cggttcgttg acgaggagtt cgaccaccgc ttcgacctgt 50401 cggccgcccc gctggtccgc atccacctcc accacgtcac cgacaccgaa ctgcgcctcg 50461 tcctcaccga ctgccatgtc gtgctcgacg gctggagcct gacctcgctc gtcgccgacc 50521 tgctcgaact ccaccggcag gccgtcgccc accgcaccgc gccgcgaccg ccgagcgccc 50581 cggccttcgc cgagtacgtg gccctggaac gggccgcgct gcacagcgaa ccgtcgctgg 50641 actactggcg cggacgcctc gccgacctgc gcccggtgag cttcgcccgg cgcgccgacg 50701 ccgacgccgg gcagcagccg ctgtacgagg tgcggcgctc ctacgcggac ctcgccgagc 50761 cgatcggccg gctggcccgc gaggcgggcg taccccggcg cacggtgctg atcgccgcgt 50821 tccaccacac catgagcctg ttcgcccagc gcgacgacag cgccctcggc cacagcatcg 50881 gcctggtcac caacggccgg cccgaggtgc cggacgcgga ccggatgcgc ggcctgttcc 50941 tcaacaccgt gcccttcggc gtcgcccggc cccgcggcag ctggatcgac tacctgcggg 51001 acgtcttcgc caccgagcag gagatgctgc cgcaccgccg cgtgcccctg gtccgcatcg 51061 cgcaactgcg cccgaccgaa cccggcctgg tcgacgccgt cttcaactac gtcaacttcc 51121 accggctcac gcacgacacc tgggacgact ccctggagat cgcccgcacc ctcttcccgc 51181 tgctggtcaa cgcgagcgtg aacggcttca cgctggacgc cgaccccgac cgggtcccgc 51241 ccgccaccgc cgaacagctc gccgacgtgc tgtgcgcgca actggccgcc atggtcgccg 51301 acccgcaggc ccgcgtcacc cggcccgcac tgaccggccc ggcgcgcacc accgtgctgg 51361 aggactgggc gcgcggcccc gaactgccct cctcgccgct cctgttccac gagcacatcg 51421 ccgtccacgc cgcccgcacc cccaacgcgg tggccgtcga gggctgcggc gaaacgctga 51481 cctacggcga actggtcgag caggcagatg agttggcgca gacgttgcgc ggcctcggcg 51541 tcggtccgga gacggtcgtc ggcatctgcg cggaacgcgg ctgcgacctg gtgcgcgccg 51601 ccgtcggcgt cctgcgctcg ggcggcgcgt tcctgccgct ggacgcccag caccccaccg 51661 agcgactgga gttcatggtc agggacagcg gtatgcgggt gctgctgacc cagcgcccgc 51721 tggcgggcac cgtacccttc gacggtccgg tgctccacct cgacgccgaa ccggacgcgc 51781 ccctgccggc ccccgccgcg gcaccgacca ccggtcccgt cgaagccgac gccgacaccg 51841 tcgcgtacat catctacacc tccggatcga ccggcacgcc caagggcgtg gcgatcccgc 51901 accgcggcct gtccaacatg ctggagggcc agcgcgacct ggtcggaccg ctcgccaccg 51961 accgggtgct ccagttcgcg tcgttcggct tcgacgcctc cgtgctggag ctcacctggg 52021 cgctcgccaa cggcggccgg ctggtgaccg ctccccggca ggcgctgcgc cccgggccgg 52081 acctggccga gaccctgcgc ggcgggcgcg tcaccggggc catgctcccg ccgagcgccc 52141 tcgcggtcct cggggaagac gccttccccg acctgcgcgt gctccaggtc gccggcgagg 52201 cctgcccggc ggagctggcc gacgtctggg cccggggccg ccgcttccag aacgtctacg 52261 gcctcaccga gaccaccgtc tggtcggtcg ccgccgacct cagccccggc cggggacggc 52321 cgcccatcgg cagcccgata cgcaacaccc gcgtccacgt cctggacgac gacctccagc 52381 ccgtccccgt cggcgtcccc ggcgagatcc acctcggcgg ccgggccgtc ggccgcggct 52441 acctcggacg ccccgccctg accgccgccg cctacgtccc cgacccctac ggggcccccg 52501 gcgagcggct gtgccgcacc ggcgacctcg gcgcgctccg gcccgacggc acggtggaat 52561 ggctcggacg ccgcgacagc caggtcaaac tgcgcggctt ccgcatcgag ctcggcgaga 52621 tcgagcacgc gctgcgccgg ctccccgagg tgcgccaggc cgtcgtgctg caccgcaccg 52681 acctcccggg cgaaccggcg ctcgtcgcct acctggtgac ggacggctca ccgggcgccg 52741 agccccggga gctgcgcctc gcgcttcgct cctcgctgcc cggctacatg gtccccgccc 52801 gcttcgtcgt cctggacgcg atgccggtca acaccagcgg caagatcgac aagcgggcgc 52861 tcccgctgcc gccggccgac cgcgccgaga gcgacatcgc ctacgtcgcc ccggccacgc 52921 ccgccgagaa gacgctggcc gaggtctggc gggaagtcct cggcctctcc cggatcggcg 52981 tcgacgacga cttcttccgc atcggcggca gctcgctgtc cacggtccgc gtctcgctga 53041 tggccgccgc ccgcggcctg accgtctccg tcggcgacct gatcgagcac cccaccatcg 53101 cccggctcgc cgaccacgtg acccgcaccg ccaccgccga actgcccgcc gccgtcacct 53161 cccgggtgcg gctgcgcgac ggcgagggag ccccgctgtg gtgcgtgcac cccaccggag 53221 gcagcgccgc ctggttcgtc ccgctcgcgc gggccctgcc gccgggccgg cccgtgcacg 53281 ccttccaggc gcgcggcctg ctcggcgggg tggacccgag caccgtggcc ggcatcgccg 53341 ccaactacgt cggcgagatg gccgagggcg aagggcaggg cccgcacgaa ctcctcggct 53401 ggtccatggg cgccaacatc gccctggaga tggccaccca actgcacgag ggcggccacc 53461 gcgtcgcccc gctcgtcctg atcgagccct acctgcccaa cccggccgcc cgcgcccggc 53521 tcaccggcgt ggcccgcgag ctgcgcgagg ccctgcggat gcgggaccgg ctgcgcagcc 53581 tgccgccgtc cccgcggcgc gacacggcgg cggccgagct caccgccgcg ctcctgggcg 53641 cgggcatgag ccccacggag gcgtcactcg tcgaggacgc cccgatcgag gtgtggcact 53701 cgctgctcgc cgccctcgcc gcgtacgagg tcaggcccta ccccggacac gtccacctcg 53761 tggtgggcag cgaggccgcc ggactgccgg ccggccgcac catgccgggc ctggacgtcg 53821 actacgcgac ctacgtcgag cgctggcgcg cggtggccgg agacgggctc accctccacg 53881 tcagcgacgg cgaccacatg tccgtactgg ccggtccgag agcggcgaac atcgcccggc 53941 tcctcgactc cgtcgccacc gcccccgagg agggccgatg accaccgccc ccgtactcgc 54001 ccccgcgttc accgagcgct acctgctctc cgccgacctc aacgccgacc cctacggcta 54061 cctcgactcc ctgcgcgagc acgctccggt ccactggagc ccgatgcacc acgcctggct 54121 cgtcaccggc tacgaccagg tcatgcggtg cctgcgccat cccgcggtct ccgcggaccg 54181 ggtgcgcccg ctgatggacg ccgtgccgca aggggcccgc gaggacgccg aacgcgcctt 54241 ctccgtgctg tcgcgctgga tggtcttcaa cgacccgccg cagcaccgca ggctgcgcca 54301 ggtcttccag gagcagttcg ccgcccggtc cgtggcccgc taccggacct tcagcgaacg 54361 cgccaccgcg gccctgctgg cccgccgctc ccgccccggc gaggacggcg acctgatggc 54421 cgacatcgcc aaaccgctcc cggcgctggt gttcgcccgc tggctcggcg tcccgcagaa 54481 ggacgccccg tcgttctggt actggaacgc ccgggtggcc gacctcgtgc tcggcaccgc 54541 ccaggaggag agcgagtacc gggcgtcgct ccaggcgctc gtcagcctgg aggactacct 54601 ggccggactc gtcgccgagc gccgcgccgc cccggcggac gacctgatca gctcggtgct 54661 cggcggcggc cgggtggggc gcacggtcac cgaggaggag ttcaccgggc tgctcaccca 54721 gatggcgttc gccggcggcg agaccaccag caacctcatc gccaacaccg tcctcgccct 54781 gctggagcga cccgaccagc tcgaagccgt ccgcgccgac cccacgctcg tgccgggcgc 54841 ggtcgaggag acgctgcggc tcgacggccc ctccaagatg tcgatccgca ccgccgcccg 54901 cgatctcgac ctggacgggc acaccgtccg cgcgggcgaa cgcatcttcc tggtgaccgc 54961 cgccgccaac cgcgaccccg aacgcttcgc cgaacccggc cggttcgacg tccggcgcac 55021 cggcgccacc cacctcgggt tcggcttcgg ggcccacttc tgcatcggcg cggcgctcgc 55081 ccgcctggtc gccgtcgccg tggtgggcac ggtggtccgc gactacccgg ccctcgccct 55141 gcgcgacccc gacgggcacg cctggcagcc ctccctgctc aaccggagcc tcaccgccct 55201 gcccgtgagc tactgaccgg cccgcgccgc ccggtcccca ccgcggcgtc cggcgcgccc 55261 cgcgcccgcc ggacgctgcc ccgcacccga tccgacgaaa ggctcaccga tggccaccac 55321 cctggaagac cgcgcgggcc cccggctgtg gacgcccgcc cgacaccgct ccttccggct 55381 gctgtgggcg gggcagtcgc tctccctgct cggcgacggc ttcagcgtcg tcgccttctc 55441 ctggatcacg ctcagcctca ccggctccac cctcaccctc ggctacgtcc tcgccttcca 55501 ggcggtgccc cgggccctgc tgaccctggt cggcggctcg ctcaccggga cctggtcggc 55561 ccgcacgctc atggtcgcct ccagctggac ccgcgccgcg ctgatggccg ccgtcggact 55621 cgccggtctg agcggcgacc tgacggtgtg ggccctgtgc ctggcggcgg ctgccttcgg 55681 caccgtcgac gccttcttcc agccggcccg cgtctcgatc ctgccctccg tcgtcgagaa 55741 ggacctgctc actccggcca acgcgctgct cggcgcgggg agccgggtcg ccgccgtcgc 55801 cgggcccgcc gtcggcggcg tggtcatcgc gatgagcgac gcgcccgtcg ccttcctcgt 55861 cgacgcggtc tgcttcgccc tgtgcggcct gttcgtcgcc cgcgtccgca ccctgccccg 55921 cccgccggct ccgcccgccg caccggccga cggcgcggag gcgggcaagc ccgccgccac 55981 gtcgctcggc gcccgcatcc gcgaaggcgt ggtctacacc tggcgcgacc cccggctgcg 56041 gaccatcgtc gtcttcgaca cggcggtcaa cttctgctac gccggaccct tcaccgtcgg 56101 cttcgccacc ctcgccgacc aggtgctgcg cggcggctcg gcgacgctcg gcgtgctcaa 56161 cggatcgctg gcaggcggcg cgatgctcgg cacgctcgcc ggcggactga tgggcggccg 56221 gccgcgcgtc ggcctgctca tcgccgggct ggccggctgg ctggccgccg ggatggccct 56281 cctcggcctg gtgcacagca ccccggccgt ggtgctgacc gtcctcgcca tgggcttcgc 56341 catcggcttc cagggcgtct tcggggtgag ctggatccag cgcaacatcc ccgaggacgt 56401 cctcagccgg gtcatctccg tcgacatggt cctcggctac gccgcggccc cgctctcgct 56461 catcgtgtgc ggggcgctgg ccaggaccgg aacgttcgcc atgttcggcg gagtggccct 56521 ggtgctcgcc gtcaccggcc tggccgtcct cgcctcccgg cccgtgcgcg ccatgcgctg 56581 aaccggcggc cgggggcggg cgctcccggc cgcggcccgt cgcggcggcg ggcggctcgg 56641 gcccgggcgg ctcagacccc gcggccgggc cgccgcgccg ccgccgaacg ggcgcacagg 56701 tcagcccggt tggccgcgcc ggtcttggtg atcagactgg cgatgtgctt ctcggccgta 56761 cgcggcgaga tgaacagccg gtccgcgatg tccttgttgc ccagccgctc ggcgagcagc 56821 ccgaagacct cgaactcccg gacggtgacg cccagggcgc gcagctcctc cggaatgccg 56881 ctggtgcccg tgcggtgctg gtgcaccgga gcgccgagcc ggcgcagcgc cgcccggcag 56941 gcgttcacga ccggaagcac gtcctgctcg tggaagtggt gctccgcccg gcgcagccac 57001 gccaccggat cgccccagcc gtccgcgtgc gccgcgtccg agatcagccg cagccccaga 57061 tggagcgcgg ccggatacgg ctccgcctcg cccagcgcct cctcgaccgc cgccgccgcc 57121 cgtgcgcccc gcccctcgcg gcccagcagg accgcgtccg cgagcagcac gaactggcgg 57181 ttccagcgca tccgccccac ggcggtggcc gagacctcct cgtgccgggc ccggtcggcg 57241 tccccggcca gcacgtccag cagcagcccg atcccgtgcg tgccgctgag gtggtacgtg 57301 ctcgggttgc cctcctccag cgcggtcacc gcccgcagtt ccgcacgggc cagctcgcgg 57361 tcctcctcca tcagggcgca gaaggcgcgg gccatgccca gcgtgagcgg ctcctcctgc 57421 gaccccgcgc cgtcccactc cgcgaacgag gccaccgccg cctccatcgc cgcccggtcg 57481 ccccggtgcg cctccagcgc cgcccgcgcc atcagcacat agcgcacggc cggggcgagc 57541 cgcaggcggc gcaccaccgc caggcactcc gccgcggcct cccgggcccg gtcgtaggag 57601 ccgcgcagca ccgcgtccag gacgaggatg ccgtccaccg tgtgcatgat gctcaccgaa 57661 ccgagccgca gcgcctcctc gcgggcggcc agcagctcgc ccgtgtcgcc gcgcgccagc 57721 caggcgttgc cgcccttgcg ggtggccgcg tacatccgct ggagcggcag ccggtggtgc 57781 tccgcggtcg ccagcgcctg gtcgagcatc gcccgggact cctccgggtc ccgctcgcgg 57841 gcgaccgtcg ccagcagctc ccacgcctgg caggccacgg ccggaagctg gtggcgctcc 57901 gccgcgtcgg ccgccgagcg ggccagcttc tcggcgtgct gggtgcggtc ggcccccggc 57961 gtgtccagcg ccagataggc cgcggtgacg tcgacggccg ccgaggccgc ctcgtccggg 58021 gccgcgccga gcacctggcg ggcgcgggcg atctgccggt tgccgtcgct ccaccgcccg 58081 gcggtgtgcg ccaccttggc cagccgggtg tgcaggacgg ccagccggga cgggctcagc 58141 ccggcgatgt ccagcgcgtg caggtgctcg gccagttcga aggcgcgtgc gaagtcgccg 58201 gactcggcga gggccggcag caggtgctcc agcgcctcgg cccggccctg cggatcggcg 58261 cccggcgcca gcaggctctc ggcccggctc agcagcgtca ccgcggagcc cagcgccccg 58321 gccgccagcg cccgtctgcc cgcctccgcg aacagccgtc ccgccgcgct gcggtcaccg 58381 gcctccgcgt gcagcccggc cgcctgcgcg caccattcgc cgggcaggtc ggggtgcagc 58441 tcccgcaccg cctccgcgcc ccgccgggcc aggtcggcgc gttgaccggg cgtcagctgg 58501 gtgaacagcg cctccacggt gagcgagtgc cggaaggagt accagtcggg cgcgggctcg 58561 tcggggatca ccagacgggc cgcgaccccg gcgtgcagat ggctgagcag gctccggtcg 58621 tcgacgccgg tcatccgctg gagcacggtc agcgggaagc gccgtccgag caccgccgcc 58681 gccgacagca gcgtcaggcc ctcggcgccc agccggtcga tccggcgcag gatgccccgg 58741 gccagcgtgg aggggacgtc ggagcgcgga tcgccgacca cccgccagcc ctcggagccc 58801 tggaccaggg tgccggcgcc gatcatcgac tggagcaact cctcgaccag gtacgggctg 58861 ccggcgctgt cctcccacag ccgctccagg atcggcgcgg gcacccggcc cgcgtcggtg 58921 ccgagctgcg cggcgatcag gccgtgcgtc tgctcgcggc tgagcggcgg gagttcgacc 58981 agcccggcca ccccgcgccg ccgggccgac tgcgccaggt ccagggcgtc gctgaagtcc 59041 gtgcggacgg tggcgagcag caggatcggc gtgttctcca ggttgtcgac gaggtattcg 59101 agcacgccca gggtctccgg gtcggcgtcg tgcaggtcct ccagcagcag gagctggccc 59161 tgcccccggt ccgaggcgat cagcaggcgc agcaccgcct cgcccaggat gaccatggaa 59221 ctgctgtccc gctcaccggt gtcccagtcg ggtatgagac gtccgaggac cggccggtac 59281 gggccgagct ccaggtcgtc cagcgcctgg ccgctgcgga acagcgccag cagcgcctcg 59341 gtgagcggcc ggaacggcac ggccgggccc gtggtgctgc tccggccccg caggacgcgc 59401 gtaccggcgg cgagcgccgt accgacggcc tcggccgcca gccgcgactt gccgaccccg 59461 gcctcgccga tcaggaagac gactccgccc tgcccccgtc tggcgtccga caacgcacgt 59521 tcgaggagga acagttggga gtcccgcccg atcaaggaga gcgcatggga actcatgaac 59581 gcagatctta atcggattgc cgggaatcgc agcaggtcgc ccgaatcccg tggcccgccc 59641 gcagcggggc gagcgggccc gcccgccgtc cgacggcccg ccccaccggc tcccggaacg 59701 gaccggggag gtcactgcgg ggaggagacc gaggtgtcca ggctcgtcag cgtgatgacg 59761 atgccgctgg tcagaaccat gcccgccagg actctgacgc gggcgcaggc gcggttgcgc 59821 ccgctcaggg cgatcccgcc cgcggcgtcg tgcccggtcg cgggggcggc cggaccgtcg 59881 agcgcggcgg cggtggcgga cggggtgccg gtgaggttct ggtccatggt ggtgagcccc 59941 ttctgatgag gtctgcgtgt gcccggagtc ggtgtgcggg tgccaggagc ggtggccgga 60001 gcggtcggac gacccgtgcc cggccggtgg gagagagtca ggagtcggtg ggcgtacggt 60061 cgcgggggtg ctggagtagg agtgcggacg gcacacggtc ggggtgcgcc aggcggagca 60121 gcccgtagcc gatgccggag agcccggtga gcaggccggg ggaggggacc cggtccgggg 60181 tggcgcagcg gtgtccctgc gcctcgacgg tcccgagcgc ctggccggtg cgcagggcca 60241 gggcgtcgga cgccgccggg tcgcccgcgc cggccagcag cgtcaacgtc tccagggcgc 60301 cgagcgcccc gtggcccagg ctcaggtcgg cccccgaggc gagggcggcc gagcgcccgg 60361 tcagggaagc ggcccgcgcc cgtccgccgg gcaggtccgc cgcggcggcc agcacaccgg 60421 ccagcccggt ggaccaggac aggtcgtcgg gcgcggccga ggccgcggcg agcgccgggc 60481 ccagcagagc ccgccccgcc ccggcgtgcc cggccctctc cggccgcagg gcggcgtagc 60541 gcagcagcgc ccagccgatg cccgccgcgc ccccggcgaa cccggcgggc ccgccctccg 60601 gcaccggagc ccgcagcagc gcgtccgcca cggcgtcggc cagccgcagc gccccggcgt 60661 cgccggtggc ctcgtggacg gcgaccgccg aggccagcgc cccggccgcg ccgcccgcca 60721 gggacaggtc cgagcaggac gcgacggcgt ggcccagcgc ggtcagcgcg tccggcaggc 60781 agtcccgcag ctcggggtcc agcacccgcg acagccgcac cagggtgtag aggatgccgc 60841 cgatcccgtc gtacgcgccg ggaccgaccg ccgcgcacgg ttcggcgtcc gccgccagcg 60901 ccttcagcag cgccggcagc gggcgtacgg cctcccgggc gagcgtcgtg taccgctcgg 60961 ccccggccag cgcgcccgcc tcggcgagga acagcgccac gccgcagtag ccctgcgcga 61021 gccccgcgcc catcggcagc acggcccagt ggtcggacgg aaagcgttcc aggcagagcc 61081 agttggatcg gccgccggcg ctcaacgccc gcgcggcgat ctcgtcggcg atgccgcagg 61141 ccgcggcgag cagccgtgag gggctggacg ccaccgcggg caccggagcc ggtaccagct 61201 ccgaacgggg gccgtccagt ggggagtcgg caccgagggc cgcgagcgtg gcggcgacga 61261 tccactcctg gtcgtggcag tcgaccccgt ccatccgccc gatcttggcg cgcaccgccc 61321 gcaggctcgc caccggcagc aggtccggca gccaggtccc gtccgccgtc ccgacctccg 61381 tgcctgcggg ccggtgcgtg aacagcggta cgtcaccgcg ccacaggtct gccgtctcgt 61441 gctcgatgag ccgctggcgc gccggatcgt gccgggactc cgtccacagg accgcgaaga 61501 ccgcgtcccg ggccagcgcg tcgccgagca gcgaggggtg ggcggactcc tccaggagcg 61561 tcgcgtagag ccgggtggcg cggaccacga tccgggccgg ggcggagccg cgggtctcca 61621 acgggccgtc gggggcgagg agttcaccgc cccgggcggc gatggccgcg tacgccgtgc 61681 ggaaaccctc cagcagcgcg gcgcggtggt cggccccggt cagggaacgg ccgccgggca 61741 gcggctggtt ctccgccccc gggctggtga ccggtccccg caccgcccgc atggtgtcca 61801 ggccggtgtc ctcccagcgc agcccctcgc tggggtgggt gccgtcgtcg gcgcggccga 61861 gcgcggagat gtccagcgcc ccgtgctcgc cgatcagcag gtgcggcagc aggcaggtgc 61921 ggtgcacgga ggcgtgcaga gcgtccgcgg ccgggtcggc cccggccgtc gtggcctgcg 61981 gcagaccggt gtgcagcagg gtctcggcgt ccaccagcac cggctggtcg gcgcaggcga 62041 tgacgttctc gtagtgcatg tccgcgccgt ccaccgcgta cagcagggcc agcagggcgc 62101 cctggcggcg gtagaaggcg tcggcctccg tcaccgagcc gcaccagcgg tgctcgatga 62161 actccagcca gccgtacgtc tcccggcgca ccgtgcgcgg tgtgcgcagg tccagcccgg 62221 acaccgcgcc gttgagccag ccggccagat cgtcgagcag cgcgtggtgt tccagcgacc 62281 gcggcttgta caccgcccgc gacccgtcgg cgaaaccgag gacggccacc gaccggccgc 62341 cctggtgggc gtcgccgcgg cccagctcga tcctggtcag cgggccgggg tcgcggcccg 62401 cgaagaggga ggcggtgagt tcggcgcggt ccgcgtggaa gcgcaggccc cactcgccga 62461 ccgcgtcggc cgcgtccagc gccgtacggc ccagcatccg ggccagcacc gggtaggcgg 62521 tgaacagggc gcacaggccc gcccggccgc cggtcgccgt gacgaaggag gcgaaccgct 62581 cacccggccc ccggccgtcc agccgcccgg cgcgtcgcgc cgcgtccagc tcgcgcacca 62641 gggtgcgggc cgccagccgg gccagccggc ggccgagcca cagctcgaac gacgccccca 62701 cgacgttccg ttcggcctcc ggcagcggcg ccagccgctc ggcgaggcgc gccgcggccg 62761 gggcggccag cgccgcaacg acgggcacga acacctccgt gtcctcgccg ccgcaggccg 62821 gagcccgcgc cgggcgggga ccgacggagg ccagcgcctc ctccacgtac cgcgcccagt 62881 ccgggacgcc ggctcgcccg gccagccgct cggccggctc gtcggccagg gccgccagtc 62941 cgtccgcgcc gatgccgagg tacgccagcc gcgccgcgaa gccctccgtg tcgccggccg 63001 cccagggggt gcggcgggcc ggggcggtcg cggccacggg ttcccccgga gcggcgacgc 63061 gctcggcgag ggagagggcc ggggcccacc aggcgttcgg caggcgcggg ctccgcgggt 63121 ttcggaggct ggcggaatca gtcacgagaa gaacgtccca gacccggtgg acccccacat 63181 ggggatgcga tccccatatt ctccccggac cccaccggca gggtggggcc cgcagtccgg 63241 cggggctccc gatccctgcc caacagccct gccacgcgag gaacatgcca gctcagccgc 63301 ggttccccgc agaccggcgg cacccgcgca gccgcaccgg gagccagggg ggaccgcccc 63361 cgccgaccct ccgctccggc tcccgcgacg ccccgcaccc ccgcccctac ccacccgagg 63421 cccccgccgg cccccatgcc gcacccggcg acccgcagaa ggcgtcacgg ccggacccgt 63481 ccggtgcggg tttccccgta cgtcccgcgt ggcggagccc cgcaccccgc gctgcccggc 63541 gggcccgcac cgcccgcgcg caccgccgcc gccccgtccc cgtacaccgc accgcacacc 63601 ggcgggggcg gcgggcgcgg gcggaggcaa aagtggggag cgagtacgga tgtccgccgc 63661 acggcgccga agaagacttc cgggcagaac gaccaggacg cccgctgtcc cctgaaccgg 63721 gcgatgatct tcggaggagc aggtggcaga aatcgtatcc gtcagcgtgg tcgccctgga 63781 cccggtgctg gaagccggca cccgcagcgc cctgacggcc tgtccggacc tgctgctggc 63841 gcggccggag gaggcgcggg tcgccgtcct caccgtcgac cggctggacg aggcggaact 63901 cgacatgctg cgcaccaccc gcgcgacccc gaaccgcccg gccgtcgtcc tggtcgccgg 63961 cgccttcgcc cccggcgacg tcctgcacgc cctggcggcc ggggcccgcg gcctgctgcc 64021 gcgccgcgag gccgccacgc cccggctctc gcaggccgtg ctcgccgccg cccgcgacga 64081 ctgcaccctc ccgccggacc tcctcgacca ggtgctcgac acctcgggcg cggcccggca 64141 cggctccggg gccggagcgg gcaacgggct gtccgagcgc gagcgttcgg tgctccggat 64201 ggtcgccgac gggcacgaga cggcggagat cgcccagcgc ctcgcctact ccccgcgcac 64261 ggtgacgacc gtcgtccacg acatcacgca ccggttccgc ctgcgcaacc gggcgcacgc 64321 cgtcgcctac gcactgagag caggactcct gtgaccgcca ccgccaccgc cctcgccgct 64381 ccgctcgccg cgactccgca gcccctggtc cacctggtcc gctcccgggg cgccgaacgc 64441 gtccacgacc tggcccgccg ggccggtctc acgtgcacgc tcggccccgc cgacgccgcc 64501 cgccccgccg ccgaaccccg caccgtcacc atcgtcgtcg ccgaggacgc cgaggaggcc 64561 ctgcgcgacg cacgggacgc cgggccctgc gtcgtcgtct gcgacaccgt cacccgggcg 64621 ggcgtgcgca tggcgctgcg cgccggagcg gccgtgctca ggaccgccga cctcaccgcc 64681 gagaacctgg cgaaggccgt ccgcagcgcg ggcaaccgcc agcccggcat cccctacccc 64741 gtcctctccc acctcctggc ggccggcccg ccccggggcc gccccgcccc ggacgtctcc 64801 acgctgccgc tcacggcacg ccagacgacg gtcctgcgcc tcatggcgga cgggcacggc 64861 aacgccgaca tctcccgcat gctctcctgc tccgagcaca cggtgaagaa cgtcatctac 64921 gaggtgatgg cccgtctcca ggcccgcaac cgggcgcacg cggtcgccca cgcggtgcgc 64981 tccgggctca tctgacgccg cccgcaccac gtgacggccc cggacacggt ccggggcctt 65041 cgtccgtcct gctcagtccg gcggaggcgg cagccggcgc ggctcgacgc gctcctccac 65101 ggcccggtcg ccctcacggg tgacgacgta ggcccccttg cccgggatct ccgtcacggc 65161 ctcgaccagc tcggtgcccc ggtagaccag gcccacgccg tcgtcggtgc agtgcgtggt 65221 gggcagggtg ccgtcggcca ccagccggtg gatcagcgga cgccgcccgc cgtccgagtc 65281 gtagtgcacg ccgttgccgt acgggaggaa gccgagcgcg tcggtgaccg ggcgcagccg 65341 gggcccgtag gagtccgtcg caccgccctg gaaccagcag atggagccgg cgctgacccc 65401 gctgagcacg acgcccgccc gccacgcgcg gcgcagcgcg ccctccagcc cgtggacccg 65461 ccacaccgcc agcagattgg ccaccgagcc gcccatcacc cagacgacgt cgtgcgccag 65521 gagcgtggcc tcgacgtcct ccacgttcgg catcgggaac agggcgagcg gcgtcaggtc 65581 gaaaccggcg taccgggccg cctcgtgcat ccgcgccgtg acgtgctccg cgtcgccgac 65641 cgccgtaccc aggtacagca cccgcgggcg acggccgtgc accccggaga ggtcgaccgc 65701 gtgatggacc agcgagtcga acagcacccg ggcgcgggct cccacccggt gcccgccgga 65761 cgtcgcgacg atggtcggct gcggtgcggt catgcgcgag atcgtaacgc gcgccccggc 65821 ccgcgcgacc acgggtgcgc gcaccgcccg cacccgccgg gcacgccgac ggggcccgcc 65881 gggaagccgg gccccgcaca gggcgtaccg cgccgttcac ggcgtccgca gggccacggc 65941 cgccgcgtac cccgccggga cgcgcacgtc ccgcagttcc cacccgggcg acgggacggc 66001 ggggaccggt ccggtgccga cgtagtcgag accggggctg cgcaccaggc cggtgcccag 66061 gcccttcagg tacgcctcct tgcggaccca ggcccgggtg aaggccgcct gccgttcgcc 66121 ctccggcagc cgcgccagct cgcggacctc cgcgacgtgc agcgcggact gcgcgccgag 66181 caccgcctgc acgcccgcca gccgctcgac gtccaccccg accggcgcgc gggccagcgc 66241 catcatcacc aggtccccgc tgtgggacag cgagaagtgg atccccgagc cccgcagcgc 66301 cggacggccg tgcggcccgc cgcagcccgc gcacggctcc cgcatcaggg gcagcgcgtc 66361 gggccggacg ccgagcaggt cgcccagcac gctgcgcagc gcggtgtgcg cgaccacgta 66421 cacgtcccgg tccgcgtccc gccggaacgc cccggcccgc gcccgctcct cggcgtccag 66481 gatctcccgg gcccgcagga gcaggcgctc gtcccggggc cgggcgtgcg ccaggtacag 66541 ctccagcggc cccgacagcg gacggggcgc gaccggatcc ggcctgcgcc acagcagcgc 66601 cgggtccagc ggggccggac gcagcgggcc gggcggcgcg taccccaccg gggccgcgcg 66661 cgcggcggcc ggcggggcgt gcgcggccac cagcagatcc ggacccgtgc ccggctcaga 66721 catcagcccc tgccaggcgc cggcgcagac tcagcggacg catgtccgtc cagacctcct 66781 cgatgtggtc gaggcactcc tgccgggcgc cgcggcaccc gtcggcgtac cagccggcgg 66841 gcaggtcgcg gtccgcccgc cagatcgagt actgctcctc gtcgttgcgc acgacgagga 66901 actcctcccg cgcctccgcc ggagcgcgct ccgcctccgt accggtcacg gtgctgtcgt 66961 tcgtcacggt ggaacctccc gcatggaatg gatcgacggg gccagcgtcc ccgggcccgg 67021 cggcgggcgg cagggacgaa cgcgctgacc cggcggcacg cgttgctgcc ggatcttctc 67081 tggtgacgcc gggggccggc gcgggaccgt actggacgtc cgcagacagc cgacgtcgtc 67141 cgaacggcgg cggggcggct gccgaccgcc ccgcccctgc cgaccgcacg gaacccggcg 67201 atccccctct ggaaggagtc ccgcatgtcg gacgaccacg gaaatgtcct gctgcccggc 67261 ggaggatggc ggctgtggga gcagttcgcg ctgcgcggac cgggcttccc cgccgacggc 67321 gtcctgcacc tggcccccgc cggactggcc gacgcggccg acaagttcgg ccccggcagc 67381 gacctcgccg gccccgagtg ggacgccttc gccgaggacg tctcccgggg tgccgtgcgc 67441 accgcgcacc agctccagga gatcgccgca ctgccgcgct tccaggccgc gctcgcctgg 67501 cagaaccccg ccgtcctgcg gaccgggatc gccccgttcc tgcggtggga cccgtccacc 67561 ggacgcagca gcatgccgcg ccagcgcgag gagctggtcg cccactactg gcagcggttc 67621 tgcgtcaaga acgacaccat cggcttcttc gggccggtcg gctggggccg ctgggacctg 67681 tccacccggg gcgtggagag cgacccgggc gacggcttcc tcgccggctc ccaggtctac 67741 ttcgccggct gggccgtcga cgccctcgtc aaggtgctgg ccggggaccc ggagctgatg 67801 cgctggatcc cgccgcaccg cgtgtcgttc gtccgcgtcg ccgacggcgc ggtacgggtc 67861 ccgggccgcc ccgcgcagcc gatcggagcg ctcgcggcgg ccgtactgga gcggtgcgac 67921 ggcacccgcc cggtcgccgc gatcgcggcg gacctcggca tcggcgcgga cgaggcggcc 67981 gacaccgtac gggagctggc ctcccgccgg tgggtgcggt ggcggctcga cgtgcccgcc 68041 gacacccacc ccgaccgggc cctgcgccgc atcctggagc gggtgcccga aggggccgcc 68101 cgcgaacggg ccctggagca gctgtccgta ctggagcggg gccgcgacgc cgtccaggcc 68161 gccggagccg acgcggtcgc gctgaccgcc gcgatcggcg cgctggaggc ggacttcgcc 68221 gcgctgaccg acaccgaggc ccagcgcacc aagggcgaac gcaccgcgcc ctgccgcggc 68281 ctggtctact ccgacgcccg ccgcgccgcc accgccaccg tcggctcggc gctcctcgcc 68341 gaactcgcgc cgctggagct gtgcctgacg gcggcccgct ggatgacgaa ccgcttcgcc 68401 cagggcgtcc gcgcccgcct gcgcaccgtc cacgaccgcc tgcgggccga cggcgaggcg 68461 gtggacctcg gcacgatgtg gctgcacacc ctgccctccc cgcacccgga ggcgggcgat 68521 ctcatcgacg ccgtccaggc cgagatgcgc gaccggtgga cccgcgtcct ggacctcccg 68581 gcggacgcgc gccgggtccg gctctcctcc gccgacctgg ccgagggcgt gcgcgccgcg 68641 ttcgacgaac cgggcgacgg gtggtcgctc gcccggtacg tgagccccga cgtcctcgtg 68701 gtcgccgagg acgagcaggc cctggagagc ggcgacgtcg acctggtgct gggcgagatg 68761 cactgcgccc tcaacacgat gggcgcctcc ctcttcgtcc accagcaccc cgaccgggac 68821 gaactcctcg cggagaccac ccgggacttc cccggccccc gcctgctgcc catgctggcc 68881 aaggagctgc cgctgaagtg gtcctcgcgc agccgcccgt ccctggaccg gccccaggac 68941 cactacgtcg ccctggtcga ccagaccggc gacccgcacc gcccccgcac gtacgcgagc 69001 gccgacgtcg ccgtcgagga ccgggacggc cggctgcacg ccgtcctgcc cgacggcacc 69061 gcctacgacc tgctcgacgc gtacgccaac accctcaccc agcgcgtcat ggaccgcttc 69121 accctgcgcc cgtccggcga ccacaccccg aggatcaccg tggaccggat ggtcgtggcc 69181 cgcgagacgt ggaacctccc ggtcgccgac atcgacttcg ccgaggagaa gtcggaggcg 69241 gtccgcttcg tccgggcccg ccactggcgc gaccggcacg agctgccgcg cttcgtcttc 69301 gtggtctccc cgaccgaacc ccggcccttc tacgtcgact tcgacagccc cgtctacctc 69361 accatcctcg ccaaggcgat ccgccggctc gcccgcaagg accccgccgc ccgcctgcgc 69421 gtcagcgaga tgctgcccac cccggagcag gcgtggctca ccgatcacga gggcagcgcc 69481 tacacctcgg aactgcgctt cgtcgccgtc gaccggaccg tcaccgaccc ggccgccacc 69541 gggcccgcca ccggggaggc gtgatgcgca ccgtcgtcga cgacatcctc gcccacgccg 69601 agcgggaccc cggccgcacc gccctgacca cgccggacgg cgacacgagc tacgccgaac 69661 tggccgcgcg cgtcacggcc ctgtcccgga cgctggccgc gcgcggcgcc ggacccgaga 69721 cggtgtgcgc ggtggccgcc gagcgcggca cggacgcggt ggccgccatg gccgccgtcc 69781 tgggccgcgg agccgccttc ctcagcctcg acaccggcca gccccgcgaa cgcctcgcct 69841 ccttcgtccg cagcggacgc gccgggctgc tcctgaccac gtccgccctc gccgcccgac 69901 tcgacctccc cgtccccgga ccgccggtgc tgctggaccg gccggtgcgc caggaccccg 69961 ccgaccgccg ccccggcccg cccgcaccgg tcgacccgcg ctcgctcgcc tacgtcagcc 70021 acacctcggg cagcaccgga gagccgagcg ccgtcctgat cgagcaccgc ggcctcgacg 70081 cctatctccg cgacgcggcg gccgtgttcg gcctcggacc cgccacggtc gccctccaga 70141 tcgcgccgct gggctacgac gcctccatcc gcgacacctt cgtgccgctg ctcgcgggcg 70201 gccgggtggt gatcgtggac cgcggcgccc tgctgcggcc cgaggagttc accgcgaccg 70261 tccgccgcta cggcgtgaac accctgctca gcgtcacgcc ctcgttcctc tcccacctgg 70321 ccggggcccg caccggccgg gacccgctgg ccggcgtcac cctggtggcg tccagcggcg 70381 agtccctgcg ccccttcctc accgccgggg gccgctccct cgtgccgggc gcgctggtca 70441 accagtacgg gcccaccgag tgcacgatga ccaccacccg ccactccgtg cccgcggacc 70501 cggacccggc cgccgacgtc gtcggccgcc ccggggccgg cgcggtcgtc cgcctgctcg 70561 acgcggacct cgcgcccgtg cccgacggca cgccgggcga ggtctgcatc gggggagtgg 70621 gcgtgggccg cggctacagc ggccggcccg cccgcaccgc ggagtgcttc gtcccggacc 70681 cgctcggccc gcccggcgcg cggctctacc gcaccggcga cctggcccgg cagagctccg 70741 agggcctgca ctacgccggc cgccgcgacc ggcaggtgaa gatccgcgga taccgcgtcg 70801 acccggcgga ggtggagggc gccctgctgg cgcaccccgc cgtcaccggc gccgtcgtca 70861 cctcgcccac cgacgcggac gggcgcgtgc acctggtcgc ccacctcacc ggcgacctct 70921 ccggcacgcc ggacgccgcg ctccgcggcc acctggtccg cctgctgccg ccgcacctga 70981 tgccgcgccg gttcgtccgc ctggacgaac tgcccaccac ccggggcggc aaggccgacc 71041 gccgcaccct ggccgccctc ggccccgccc cggcgcgccc cgcgcccgac gccgtccggc 71101 cgcccctcgg gaccgggcga tgaaggccgc cgccctgcgg ccgggccccg ccgacctcgc 71161 cgccgccgcc gaccgcatcg cccggcacgt ggtccgcacc ccgctgctgg ccggcccgag 71221 cgcccggccg ggcggaccgc gcatcctgct caaggccgaa cacctccaga acggcggctc 71281 gttcaagacg cgcggcgcgg ccaacgccgt cctcgccctg gacgccgtac gcctggtcac 71341 cggctcctcc ggcaaccacg gcatcgcgct ggcccggctc gcctcctcgc tcggactgcg 71401 cctgacggtg gtcctcgcgg ccggtgcggt cccggccaag gccgccgcca tccgggcgct 71461 cggcgcgagg accgtgcacg tgagcggcgg cgtcgccgaa cgggacgagc gggcccgcga 71521 actggccgga cggggcgacg ccctcctcgt accgtcctcc gaccatccgc tggtcatcgc 71581 cggacagggc accgtcggcg ccgaggtgct ggccgacgcc cccgacaccg agaccctcta 71641 cgtgcccacc ggcggcggcg gactgctcgc cggagtctgc ctcgccgccc ggcaccaccc 71701 ggtgcgcgtg gtcggcgtcg agcccgccac gaccccgcgc tacgcccgct ccctcgccgc 71761 cggccggccg ctgcgcctgc cgcccggctc caccgtggcg gacggactgc gcggccagtg 71821 cccgggaacc ttcacctacc cgatcgtcag cgaccgggtc gacgacatga tcgccgtcga 71881 cgacgccgag atcctggccg ccgccgaact gctgcgccgc cacggcgcgg aggccgaacc 71941 gagcggcgcg gtcgccctgg ccggcgcgct gcgcgcccgc cgccgcgaac gcgccgtggc 72001 cgtcgtctcg ggcggcaaca ccgccgcccg cctgcacacg ctcgccctca cccacgccct 72061 caccggcgca ctcaccaagg agaagacgtc atgaccccca acaccgccac cgccaccgcc 72121 gccaccaccg cgaccggcac cctcgacctc ctggtcggca tcttccgcga cgtgctcggc 72181 ctggccgacc tcaccgccga ctgcgatttc tacgaggcgg gcggcgactc gctcaccgcc 72241 ttccagatca ccggccggct ccaggaggcg ctgggggcgg agatcccggt ctcgctggtg 72301 ttcgcctacc ccacgcccgc cgacctggcg gaggtcctgg acgccgacta cggccgcgcc 72361 tgacaacgcc gtaccgccgt acgacgaagg gcgcgagggc gcgaggacgc ggctatgggg 72421 gccggcccgg ccccggaccg caccgcccgt cggcccgccc gccgcaccgc ccgcccgccg 72481 tgccgtgaca ccgccgcatc caccgtgaac gcgtgaacgc gtaaggagaa cgccgccatg 72541 accgacgacc tcgtgccgtc cctcggccgc tggaggctgt gggagcagtt cgccctgcgc 72601 ggaccgggct tccccgccga cggagtgctg aggctggccc cgcccggact ggcccgcgcc 72661 gccgacaagt tcgcccccgg cgacgcgctc gacgggccgc tgtggcagga cttcgcccag 72721 gtcttcgccg gggcgtccgt cgagaccgcc ctcaccctcc aggacatcgc ccgcaccccc 72781 gccttccgcg aggcggtcgc ctggcagaac cgcccggtgc tcacctccgg catcgccccc 72841 ttcctgcgct ggaccccgac cgccgcgagc cgcagcagca tgccgcgcca gcgcgaggag 72901 ctggtggccc actactggca gcggttctgc gtcaagaacg acaccatcgg cttcttcggc 72961 ccggtcggct ggggccgctg ggacggccgc gccgacggcg tcgagaccga caccggcagc 73021 ggcctgaccg ccgccaccac cgtctactgg gccggctggg ccgtcgacgc cctcgcccgc 73081 accctggccg ccgaccccgc cctgcgcgag tggaccgccc cgcgccgcat cccgttcgtc 73141 ggcctggacg gccgcaccgt cacggtgccc ggccgccgcc cggtgaccgt ccccgccgac 73201 accgccgcgg tgctcgcccg ctgcgacggg gtccggccgg cccggcggat cgccgccgag 73261 ctgcccgacg tcgacgtgac cgccgtcctg gaggacctgg tcgcccgccg ctgggcggtg 73321 tggcggctgg agatccccgc cgacacccac cccgaccgcg cgctgcgggc ctggctggaa 73381 tcggtggacg cagacgagcc gcgccgccgc ggactggccg cgctcgaccg gctggaggag 73441 ggccgcgccc gggtcgcggc ggcccggggc gccgacgcgc tcgtcgcggc gatgacggcc 73501 ctggaagagg acttcgtcga cctcaccgag accccggccg tacgggagaa gtccgcctcc 73561 accgccccgt gccgcgcgct ggtctacgcc gacacccgca gggccgccac ggtccggctc 73621 ggcagcgccg tgcacgacgc gctcgcgccg ctgcgcccgc tgctggacag cgccggctgg 73681 atcacctccc gcctcgccga aaccgtggag cgggaggcgc tgcgcgtgca cgccgccctc 73741 gcggccgagg gccccgtcga cctggcgtcc ttctggttcg ggtgcctgcc cgtgctgcac 73801 ggccccgcgc gcgcggcggc ggacggcgtc caggcggact tccgggcccg ctggcaggag 73861 atcctcgccg tcccggcgga cgcccgcgat gtccgcctcc gcctggcgga catcgcggaa 73921 ccggtccgcc ggcacttcgg cacgcgcggc ggaggctgga cggccgcccg ctacatgagc 73981 cccgacgtca tgatcgccgc cgacggcgcg gacgcggtcg cccgcggcga cttcaccctg 74041 gtcctcggcg aactccacct cgcggcgaac accctgggcg cctcgctctt cgtgcaccag 74101 cactccgacc cggccgagct tgtacgcctc accgaccgcg accacccggc accgcgcctg 74161 ctgccgctga tcccgaagga gcaccgcgca cggctctccg cccgtatccg caacagcctc 74221 gtgcgtcccg gcgaccacca ggtcgcgctg gccgacttca ccgcggaccc ggcgcggtcc 74281 cgcgcggtgc gcagcgcgga cgccctggtg gaactccgcg acggggcgct cgtggtgctg 74341 ctgcccgacg gctccgcgta tccggccatg gacgtgttcg cgcacgtgct gaccacgctg 74401 gcgatggatc tgttccagat cctcccggag tcggaccact cgccccgggt gacggtcgac 74461 cggctggtgg tggcccgcga gacctggcgg ttcaccgcgg cgcgggccgc gttcgccgac 74521 gagaaggacg aggcccggcg cttcgtcggg gcccgccgct ggcgggccga acacgggctg 74581 ccgcgcttcg tcttcgccgt atcgccgacc gagtcgcgcc ccttctacgt cgacttcgac 74641 agccccgtct acgtcaccat cctcgccaag gccctgcgcc ggctggcccg caaggacccg 74701 gagggccgga tcacgttcac cgagatgctg cccacgcccg agcagacctg gctgagcgac 74761 gacgagggcc gccgctacac ctccgaactg cgcttcgtgg cgtacgacga ggaggcgggc 74821 agctgagacc cgggcggctc cggccgcccg acggcaccca gggcgggcga ccgccgccac 74881 ggctccccgg gaggccgccc aggagtgagg agcgctccgg gtggggaggt ctgaaccgtc 74941 gacggatctt tgttcgacgt ggtcaggcga gggggagccg cagatgcgtg gggaagtcgg 75001 ggcggggtgg agagcccgtc tgctggggcc ggtggagctg tggaccgggg cggagagcgt 75061 cctggtgacc ggcagacagg gggcgttact ggccggactg ctgctgagcg gcaaccgcgt 75121 ggtctccgtg gaccggctgg ccgagtcggt gtggggcgag ccgctgccga ggtcgcccgc 75181 cgcgcgcgtg cggatgctgg tctccgagct gcgcaggacg tgcgcggcgg cgggctccga 75241 tctcatccgc acgcaacgac ccggttacgt cctgccgctg gaggccgggc agttggacct 75301 gacgcggttc caggacgggg tggcgctcgc ccgtgaggcc gccgccgcgg gcgatccggc 75361 cgccgcggtg gcccgcttcg acgaggcgct gggcctgtgg cggggcgcgc cgctggaggg 75421 ggccgccggc cgtttcgtcc cggcggaggc ggcccggctg gaggagctgc ggatcggggc 75481 ggtggaggag cgggccgagg ccatgctcgc gttgggccgg cacgtggagg tcatcagcga 75541 gctgggaccg gtcgtcgccg gccacccgct gcgcgagccc gcgcacagcc gcctcatgct 75601 cgccctgtac cgaggcggca ggcgggccga ggccctggac gtctaccggc ggctgcgtga 75661 acgcgtcgtg gacgagctgg gcctggagcc cgaacgcgaa ctccagcgac tgcaccagcg 75721 gatcctcacc gccgacaccg ccctggaccg gccgggaccg ccaccgggcg gcgcaccgca 75781 cgcaccgtac gcggcgcggg caccgcaggc ggcgcgcccg gccgcccgcg ccgctcctgc 75841 cgctccggcc acctctgccg ccccggacga gccggacgag ccggacgagc cggaagtccc 75901 ggacgagccg gaagtcccgg accagccgga agtcccggcc gaggcgcaag gcccggaagt 75961 cccggtcgag ccggacggca ccccggcagg accgggggcc tccgtctcgg cggccgacgc 76021 gcgggaggac acccgcaccg gcgcgctcgc cgcacccgtg ccgcgccaac tgcccgctcc 76081 accgcccctg ttcgtcggcc gcgaccacga acgcgccgaa ctcgaccggg tcgcccgcga 76141 ccgcgagccg ggcggcgtgg ccatcgccgc gatcagtggc gtcggcggca tggggaagac 76201 ctggctcgcc cttcagtggg cgcacgacaa cctcgcccac tgccccgacg gccagctcta 76261 cgtcaacctc cgcgggttcg acccggccaa ccgcccgctg cccgcgcggg cggcgctgcg 76321 ccacttcctc ggctccctcg gcgtgcatcc ggccgtcatc cccaccgagg aggaggccca 76381 ggccgggctc taccgctcgc tggtcgccga ccgccggctg ttggtcgtgc tggacgacgc 76441 ccgcgacctg gcgcagatcg agccgctgct gccgggcggt tccgggtgca ccgtcgtcat 76501 caccagccgc aaccggctcg ccgggctgca cacggcccac ggcgcccgcc tcatcgagct 76561 gggcgcgctg tcgagcgccg agtcccgggg gctgctgacc cgccgtctgg gccgggcgcg 76621 ggtcgaggcg gatccggcca gcgtggcggc gctggtcgag cacagcggcg ggctgcccct 76681 ggccaccggg gtgctcgcgg cgcgcgccgc cctgcatccc gacttcccgc tgtccgtcct 76741 agccgacgag ctgcggtccc ccgcgacccg gctcgacgcc ctgcgcgccg gcgatctgca 76801 caccgacctg cgggccgcct tcgcctcctc ctaccaggcg ctcgacgccg ccgccgcgcg 76861 gctgttcgcc ctgtcgggac tggtcccgtg gccgggcctc accccgcaca cggccgccgc 76921 cctcgcgggc gtgccggtct cccgggcccg actgctgctg aaccacctgg agagcgccca 76981 cctggtccac cagcaccgcc agggccagta ccgcacccac gatctcgtcc acctctacgc 77041 cgcggaacgc gcccggggcg acctgaccgc ccaggaccgg cacgaggcgc tgacccgcct 77101 ggtcgacgcc ctggccggca ccgcgtgcgc cggcgaccgg ctgctgtcgc cgcaccggcc 77161 gctgagcacc cgtatgtcgc ccaccaccgg accgggcgaa gacccggacg ccggtgagga 77221 gttcgcggac gcggcggcgg cctgggcctg gttcgaggcc gagcagccca acctcgtcgc 77281 cgcgcaggag ctggccgccc ggctcgaccg ggagaccgcc gtgctgcgcc tggcctgggc 77341 gatggacccc ttccacatcc gccggtgcca gcacgatctg cgcatcttcc tgtggcgtac 77401 cgccctggcc tcggccgacc gctccggccg ccgctccacc cgggccttcg cccactggta 77461 cctgggatac gcctacgcgc aggccgggcg gaccggcgac ggggtcgagc atctggagct 77521 cgccctgagc ctgttcgagc aggacgggga ccgggcaggg caggcgcaca ccagccacac 77581 gctgggctac gcctgggccg tacggggcga gccgggccgg gccatcgtcc acgcggagaa 77641 cgcgctgcgc ctccagcggg cactgggcga tccggtctgg gagggcaacg cgctcagcgc 77701 cgtcggctgg tgccacgcca agctggcccg ctacgagcag gcgcgctcct cctgcgagcg 77761 ggcgctggag ctcttccggc ggcacgccga cgccaacggc gagtccgccg ccctcgacag 77821 cctgggctac atcgcgcacc ggaccggacg gtatccgcag gcgctggagt actaccaccg 77881 ctgcctcgcg ctgcgcgaac ggctcggcaa cacctaccag ggcgcggaca ccctggtgcg 77941 cgtcggcgac gtccagcacg agatggggcg gcccgccgcc gcgcgggacg tctgggaacg 78001 ggccctggac ctctaccggc ggcagcaccg cccggcggag gccgagggcg tccgggagaa 78061 gatcagatcc gcagcgagga cttccgccgc agccgtaccg acaggttgcg cggcagcagc 78121 agaccgccga agtccggcgt gacggcggct ccttcgctcc gggtgatctc catgccgccg 78181 acgagccaga acgtcgccag cgtgagctgc atcatgccga gctgggtgcc gacgcagacg 78241 cgcggtccgg ctccgaaggg caggtaggtg tggcggaccg gcgtgctgtg cgggtcgagc 78301 caccgctcgg gcaccagccg gtccggctcc gaccaccagc gcggatcgcg gtgcagccgg 78361 tacatgctga acatgacctg gtcgccggtc cgcagccgcc atccgtccag ctccgtgtcc 78421 cggcgcacgg tccggccgat cagccaggtc ggcggccaga gccggagcac ctccttgacg 78481 aaggcctccg tgtacggcag cgcccccatc tccgggaccg tgccgtcggc ggtggccgcc 78541 tcggcctcca gcctggccag gacgtcgggg cgctcgccca gttcgtacac gatccaggcg 78601 agcgcggtgg cggggacgcc cagcgcggcc agcatgatcc cgcgcaggaa ccgttcgatc 78661 tggaggtcgg acagctcctg gtcgcgcggg gcgagcagca cgcccagcag gtcctggacg 78721 ggcgactccc cggccgaccg ccggcggcgc accagatcgg tcatgagggc cagcagccgc 78781 tcgcgcgacg cggtgaaccg gcggaccttg cgcgagggcc accaggccgg gaactggagc 78841 gagttgcgcg agagcgggtc gatggcggcc acgttctcgg ccagcgcctc cggcacgccc 78901 gccgcgtcgg ggccgaggca gaagtcggcc gtcgcccggc cgaagaagtc ggtcatggtg 78961 gcgagcacgt cgagctcgcc gtcgccgacg gtgtccagga agatctcgtg cagccgctcg 79021 gcgtgcgcct gtgccacgcg ccggtgcagc ccctgccagc ccgcgcggcg ggtcgtggtc 79081 cagagcttgg cgtcgtccgc catccgctcg gtgtccacgg ggcccgcgag cggggagttc 79141 tcggcgagga agtcctcgtt ggtccgggtg agcagcgcgt gcacctggtc cggtgaggac 79201 accacgacgg tgcgggcgtc gaaggagaag acgtcgccga attcacggtg acaccgttcc 79261 aggaacccgc ttcggtcgcg gtcgtagtcc tcgctgttgc cgaacagcca gtggccccgg 79321 ggccccggcg gtcggtccgg accagatgca cgcttcacgc ttgtgccccc tcggaccggt 79381 tagttgaaga tgttccagta ggtgtacatg ccacccatac gaacccggcc catcatgcgg 79441 acggctgcgt gtcggacgtg cctcatgtcg tacctccgta ggagcaggcg atcggtcagg 79501 aaccacgatc gtccatgggg cgcacgctct ccgcatgaaa tccgcatgcc cggcggcatg 79561 cggggccggg ccggggccac gcggaggccg cgaccgccgc acgccgggga tcacgcgaag 79621 cgcacccggg ccccctcggc gccccgggcg gcggcgaccc gtccggcctc tgcctccacc 79681 gaccggcgga cggcggcggg cagcggggcg aacgcggtca cggtcacctc gaccgtgccg 79741 ccaccgcctc ccgcgccgtg cgaccgcgcc cgccagatcc cgacgacctc cgagccggcc 79801 agcaccgcgc ccggcccgcc gatgggccgc cagacctcct tctgccggcc cctctccggg 79861 acgacgagcg cacggtcgcg cgcctggagg tacgggtcgc ccggcgggag cagccgcacg 79921 gcgtccccgc tcgtcgcggc ccgcagttcc ggcagccggg actccgggag ccaggcgctc 79981 ctcccgtcca ccgcgacctc ggccaggccg tccggccaca ccgcccggac caccgccggc 80041 ttcgtgccga ggaaggcggc ggcctcggcc ggggtggcgg gcccgaggaa ccgcaggtag 80101 gcccggacca gtccggccgt ccccgaggcc gcttccggca ccgggaacgg ctccgccaac 80161 ggcgacagca ccgtcctgcc ccgctccgcc gcgacgccca ccgaaccgaa gagcgcggcc 80221 tgctggaaga gcagcccgga gatgtgccgt gcgccgcacg tcgcgcacca gtacgtcagc 80281 gacggctcca ccgccgcgct caccgccgta ctgacctcgc ccttggccgt cggctcggtc 80341 accgccgccc ggaacgcctc ggcggtggcc cggaaggcgg ccagccccag ccgcgcgccc 80401 tccctgatcg aggcggtgct gatccgggcg gtcgcgtcgg cgtcgtcgag cggccacagc 80461 gccccggcca acgcgggcag ccccgcccgc cggtgcagat gaggcgcgcc ccggaacgac 80521 cagaccagct ccaggccgtc cggtgaggcc ccgcgcgcgg ccagggcgat ccgcgccgaa 80581 ccgtacgggg tgtcctggac gccgagcgcc aggacctccg gagcggccaa ggagcggtcg 80641 aggccctggg ccgcgacgcg gtaggccagg acctgttcac gggtcacgtc gatccggccg 80701 gcgtcgctca acggctgctc ccctcgcggg cgtggtgtcc gtacgctacc gccggggtcg 80761 gggaagaacg cggaacgccc gccgggagcg ccgcgcgccg gggacgcgga cgcggacgca 80821 cgcggcgacg gctccgcccg gcgacggccc cgcccggcga cggccccgcc cggctgtgaa 80881 caggccgccc ggccgccggc cccggatcag tccgcgtcga ggatcttgcc catcagccgc 80941 gtcagggtcc ggcgctcggc cgccgtgagc gcgccgaagg tccggtccag caggcgcgga 81001 acgctgtcct ccgccgcctc cagcacggcc gccgcctccg ccgtcaacgt caccgcgtag 81061 gccctgcggt cccgggggtg ccggtcgcgg cgcaccaggc cggagccctc caggccgtcg 81121 atgcatccca ccatcacgct gcggtcgatc cgcaactgct cgctcagctc ctgctgggag 81181 caggggccga cgtcgtcgag catcttcagc acgaggtgct gggacgcggt gaggcggcgg 81241 cccgccagtt cctcgtcgat cacgcgcgcg gccagcgtcg ccgcccggca catcgcgatg 81301 tcggggcgct cccgcgccag tctggagaag taccttccgc tgacccggag ttcggggttc 81361 cggccgggcg aggtgagtcg ggaaggctcc gttgcggtca tgactgctcc tcctgcggtc 81421 cgggacgacg agtcatccgg cggtgcgggg ccgtccggat ccagaacgtc ttccgccggc 81481 cagcctaagg gctgccccgc ggctaccggg ggtcgcgcgg cggcggccgg ggccgggacc 81541 tgcgcggggg cggagtgcgg ggccgtcgga cacctcggta cgttttagct taggcttacc 81601 taaccaaacc tgctcgtccc caaccacgag gaacacccat gctcggcttc acccgcgtgc 81661 gccgccacac cctcgccgct tcggccaccg ccgccgcctt cgcactcgtc ctggtcggct 81721 gctcctcgga cggcgacggc gggaagaccg gggcgaagga cgcggccggg agcgggggcg 81781 ccttcccggt ctccatcaag agctcgctcg gcaccgcgac gatcgacgag aagccggagc 81841 gcgtcgtcac gctcggacag ggctcggccg agacggcgat agccctcggc cggaccccgg 81901 tcggcatcga gagctacccg tggggaagcg acaagtccgg ttacctgccc tggatcaacg 81961 aggccgtgaa gaagtccggc gacgagctgc cccagcagtt cacgggcggc gaggagatcg 82021 acttcgaggc catcaccgag ctggagccgg acgtcatcct cgccccgtgg tccggcatca 82081 cgcagaagca gtacgacgtc ctcaaggaca tcgcccccac ggtcgcctac cccgaccagg 82141 cgtggagcac cgactgggac cagcagatcg acatcatcgg caaggccctc ggtcggagcg 82201 aggacgccga cggcctcaag accgccatcg agaagcagct cgccgacgcc gcggccaccc 82261 ggccggacta ccgggacgtc accttctcct acatctacaa ctccggcccc ggcaccctcg 82321 gcgtcttcaa gcccgaggag cagcgcgtca agatggtctc ctcgctcggc ctgaaggtcg 82381 acccggtcgt cgacaccttc aaggagaccc ccggcaccga ctccgccctc atcgggctgg 82441 agaacgccga gaagctcaag gacagcgaca tcgtcttcac cttctacacg gacgcgaaga 82501 accgcgagga gatcgagggc cagaagctgt acggcgcgat cccggccgtc aagaagggcg 82561 cggtcgtcgc cgccgacgac aactccttcg tcaccgcctc ctcgatcatc aacccgctca 82621 ccgtgccctg gacgatcgag cgctacctgc cgatcatcga caaggccgtc gaggccgccg 82681 gcaagtagcc ccggccgggc accccgacca ccgaggccac gaggcacact ccactcccat 82741 ggcaaccacc acagccgcac cgccgagcgg cgccggcgcc tcccgcgccg gcgccgcccg 82801 ctcggccgcc ctcctgctcg ccgggtcggc cgcgctggcc ctcgccctgt gcgcgagcgt 82861 catgttcggc agccgcggca cctcgttcgg cgacgtcctc gacgtcctca cgggcagcgc 82921 cggccccgac gtcaccgtca tcgtcgagag ccggtacccg aggaccgtcc tcggcgtcct 82981 cgccggcgtc tgcctcgcgg tcgccggcac cctcatgcag ggcgtctcgc gcaacccgct 83041 ggccgaaccg ggcctcctcg gcatcaacgc gggggcctcc gcgagcatcg tcgcggccac 83101 cgcctggttc ggcgcgtccg gcgccaccga caccatgtgg tgggcgctgc ccggggcgct 83161 gctggccggt gtgctcgtcc acgtgatcgg ctccgccggg acgggcgtcg gcgtggtgcg 83221 cctggtgctc gccggcgcgg tgctcaccgc cgtcctgacc gcgttcgtcc aggcggtgac 83281 cctcagcaag ccgcgggtct tcgacagcta ccgctactgg gtcgtcggag ccctcggcgg 83341 acgggacttc gacgtcttcc tctgcgtcct gcccttcgcc gccaccggcc tcaccctggc 83401 cctcgccctg ggccccggcc tcaacgcgct cgccctcggc gacgcgaccg cgctcggcct 83461 cggctcgcac cccgcgcgca cccgcgccgg cggcctgctc gccgccaccc tgctcagcgc 83521 cgccgcgacc gccgccgtcg gcccgatcgc cttcgtcggg ctcgccgtac cgcatgtcgt 83581 acgcgccctg gtcggcgtcg acttccggtt ccagatcctc ttctccgccc tgctgggccc 83641 caccctgctg ctcctggcgg acgtggtggg ccgggtcgtc atgcgcccca ccgaactcat 83701 ggtcggcgtc gtgaccgcct tcatcggcgc gcccgcgctg ctcgtcgccg tacgcaggat 83761 gaaaggggcc tcgtgaccgc cacccagcac accgcccgcc gccccgccgc gccccggggc 83821 tacctggtcg tcggccgcac cgtggcgata ccggtgcgcc gggcctcggt cctcgcgggc 83881 accgggctcc tcgtcctgct gctcgccgcc gccgcggcga ccctgaccct ggggcggctc 83941 ggcctcgacc ccgccgacct gcccgccgcc ctggcgggcg acgccgaggg caaggaccgc 84001 ttcgtcttca accggctgcg cggcccccgc ctgaccgtcg ccgtcgcgac cggcgcggcg 84061 ctcggcctct ccggcgcgct cttccagtcc gtgacccgca acccgctcgg cagccccgac 84121 gtcatcgggc tctccgccgg agcgggggcg ggcgcggccg tctgcgcgct gatgttcccc 84181 ggcgcggtcc cggtcgccgt cggcgcgctg atcggcgccc tcgccgccat ggccctggtg 84241 tacgtctcca ccggcaccgg cttccgcaac ccggcccggc tcgtcgtcgc cgggatcggg 84301 gtggccgcca tgggcgcggc cgtcacccag tacgtcgtct acgcgctgga acgcgacaag 84361 gcgtccgtcc tcaccgccta cgtcaacggc agcctcaccg cccgttcctg gaccgacgcc 84421 accaccatct ggctggtcct gctggcggtc gccccgctga ccgccctgat ctcgcggcgg 84481 ctggtcatcg gggagatggg cgacgacatc tccgaagggc tcggatccga gccgaagaag 84541 gccaagagcc tggccgtggt gctcgccatc gtgctctcgg cggcggccgt cagcgtcgcc 84601 ggcccgatcg ccttcatcgc cctgacggca ccccagatcg ccaagcgcct cacccgcgcg 84661 tccggcccgc acctgctgct ctccgcgctg accggcggac tcctgctggt gatcgcggac 84721 ctctgcgcgc agcacctgcc gctgtccgag gatctgccgg tcgggatcta caccatggcg 84781 atcggcggcg cctacctcgg caacctgctg atccgcgagt ggcgca //