LOCUS       NZ_ML123034            23315 bp    DNA     linear   CON 23-MAY-2024
DEFINITION  Streptomyces sp. ADI96-02 scaffold001, whole genome shotgun
            sequence.
ACCESSION   NZ_ML123034
VERSION     NZ_ML123034.1
KEYWORDS    WGS; RefSeq.
SOURCE      Streptomyces sp. ADI96-02
  ORGANISM  Streptomyces sp. ADI96-02
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Streptomyces spp. from the marine sponge Antho dichothoma: analyses
            of secondary metabolite biosynthesis gene clusters and some of their
            products
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6907715)
  AUTHORS   Guerrero-Garzon,J.F., Zehl,M., Urban,E., Schneider,O., Ruckert,C.,
            Busche,T., Kalinowski,J. and Zotchev,S.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-NOV-2018) CeBiTec, Bielefeld University, Sequenz 1,
            Bielefeld 33615, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Newbler v. 2.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 64.8x
            Sequencing Technology             :: Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_003846185.1-RS_2024_05_23
            Annotation Date                   :: 05/23/2024 03:48:04
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,089
            CDSs (total)                      :: 6,032
            Genes (coding)                    :: 5,843
            CDSs (with protein)               :: 5,843
            Genes (RNA)                       :: 57
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 189
            CDSs (without protein)            :: 189
            Pseudo Genes (ambiguous residues) :: 0 of 189
            Pseudo Genes (frameshifted)       :: 68 of 189
            Pseudo Genes (incomplete)         :: 155 of 189
            Pseudo Genes (internal stop)      :: 10 of 189
            Pseudo Genes (multiple problems)  :: 42 of 189
            CRISPR Arrays                     :: 2
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:00:53
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3765237
            Orig. end                         :: 3788552
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            ML123034.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Zotchev Lab, Department of
            Pharmacognosy, University of Vienna.
            Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
FEATURES             Location/Qualifiers
     region          1..23315
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="14"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23315
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23315
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13315](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13315
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(297..317)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.83"
                     /tool="antismash"
     misc_feature    419..434
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.17"
                     /tool="antismash"
     misc_feature    complement(637..650)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.61"
                     /tool="antismash"
     misc_feature    851..864
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            complement(1131..1769)
                     /locus_tag="EES43_RS16580"
                     /old_locus_tag="EES43_16385"
     CDS             complement(1131..1769)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018961871.1"
                     /locus_tag="EES43_RS16580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16385"
                     /product="ATP/GTP-binding protein"
                     /protein_id="WP_124269432.1"
                     /transl_table=11
                     /translation="MDSATSDRAALSATADNGLKIVVVGGFGVGKTTMVRSVSEIRPLN
                     TEETMTRAGEAVDHLDGVQAKTSTTVAFDFGRITLDARSVLYLFGAPGQERFWFLWDRL
                     FSGTLGAVVLVDTRRLADSWYAIDRLEHHGTPFIVACNDFGGPLHSEQQIREALDLSDD
                     VPLVECDARDRSSSKYVLITLVEHLHKLSAARSPRAALASARPTPEPAP"
     gene            complement(1750..2121)
                     /locus_tag="EES43_RS16585"
                     /old_locus_tag="EES43_16390"
     CDS             complement(1750..2121)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015610481.1"
                     /locus_tag="EES43_RS16585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16390"
                     /product="DUF742 domain-containing protein"
                     /protein_id="WP_124269433.1"
                     /transl_table=11
                     /translation="MTTPPRSRPGRDDDPDRLYTLTGGRSRSDSASFDLVTLVVAECDP
                     TPGMQSEHVAILRMCAGPTAVVEISATLGLPVSIVRIMLCDLLDTGRISARHPRTARVA
                     DRLPDPDILEQVLVGLRNL"
     gene            complement(2118..2555)
                     /locus_tag="EES43_RS16590"
                     /old_locus_tag="EES43_16395"
     CDS             complement(2118..2555)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018510830.1"
                     /locus_tag="EES43_RS16590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16395"
                     /product="roadblock/LC7 domain-containing protein"
                     /protein_id="WP_124269434.1"
                     /transl_table=11
                     /translation="MTATTDEKLNWLLEGLLDRTPGTRHALVLSRDGLKLCRTPELSVD
                     QADQLAAISAGIQSLSHGASIEFGDGTGGVRSAMAEFYGGVLFIVEAGAGAHLAVVADE
                     DSDVGLVGHNMSELVEQLGEHLVAPPRSPSATATAAETPAV"
     gene            complement(2552..4081)
                     /locus_tag="EES43_RS16595"
                     /old_locus_tag="EES43_16400"
     CDS             complement(2552..4081)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012379651.1"
                     /locus_tag="EES43_RS16595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16400"
                     /product="ATP-binding protein"
                     /protein_id="WP_124269435.1"
                     /transl_table=11
                     /translation="MRPSFRPTALALLISAAATGALTLWAVIAAPDSVRTPLAWGAGAA
                     AVVVSVCVAVAAHTLGTTRTLRARRAADAERFTAETSRMVSASSAEAQRFTAETARIKG
                     AASAETARLAAEARAESTRLTAEAAAERARLNAAVERLTARATRAETERSAAVAACANA
                     AGRMQALATSMLADLREMEHRHADESVLGDLLHLDHRTAQAGRLADSIAVLTGARSGRR
                     WAKPIVMESILRGAMGRIGSYQRVRLHSTSDVAIAGHAAEGVMHALAELLDNAANFSPP
                     TAEVHVYVEEVPAGIVITVEDSGLVMSEVQLRRAEKAVSAENQDLTNLSGTRLGLAVVG
                     RLARKHGLTVSFRPSARGGTGALMMLPQDLISRAATRVQGEAATTTPARQPAPAEPEPA
                     HAPAARPSATAEASRPAPGDGHQDSAGTAPDGSASEATGGVPAFGESGLPKRRRGRTLA
                     AAESRTGNAASGRAETDPGRTTTDPKVQAARFSTFSKAVRANTPLPEGNTR"
     CDS             4094..4306
                     /gene="allorf_3769331_3769543"
                     /locus_tag="allorf_3769331_3769543"
                     /protein_id="allorf_3769331_3769543"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MADGAGAGANQDSPSREWKIVTTGADNSCSSLGHYRRIGDQFGKF
                     WWAFMCDLPAFIRPHPKSSRGSTAS"
     CDS_motif       4094..4120
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MADGAGAGA"
                     /locus_tag="allorf_3769331_3769543_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       4121..4306
                     /prepeptide="core"
                     /locus_tag="allorf_3769331_3769543_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.30"
                     /molecular_weight="6673.4"
                     /monoisotopic_mass="6669.3"
                     /core_sequence="NQDSPSREWKIVTTGADNSCSSLGHYRRIGDQFGKFWWAFMCD
                     LPAFIRPHPKSSRGSTAS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MADGAGAGA"
                     /leader_location="[4093:4120](+)"
                     /alternative_weights="6691.4"
                     /alternative_weights="6709.4"
                     /alternative_weights="6727.4"
                     /alternative_weights="6745.4"
                     /alternative_weights="6763.5"
                     /alternative_weights="6781.5"
                     /alternative_weights="6799.5"
                     /alternative_weights="6817.5"
                     /alternative_weights="6835.5"
                     /alternative_weights="6853.6"
     misc_feature    4180..4195
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.01"
                     /tool="antismash"
     misc_feature    complement(4312..4326)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.25"
                     /tool="antismash"
     misc_feature    complement(4434..4445)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.32"
                     /tool="antismash"
     gene            4473..7193
                     /locus_tag="EES43_RS16600"
                     /old_locus_tag="EES43_16405"
     CDS             4473..7193
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018540362.1"
                     /locus_tag="EES43_RS16600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16405"
                     /product="FAD-binding and (Fe-S)-binding domain-containing
                     protein"
                     /protein_id="WP_241192667.1"
                     /transl_table=11
                     /translation="MDASNYRRVPLGVLAPRDADDIAAALAVCREHGVPVVARGGGTSI
                     AGQATGTGLVLDLTRHLSAVLDLDPAARTAVVQPGVVLDDLRAAAAPHGLTFGPDPSTH
                     SRCTLGGMIGNNACGSHSVAWGTTADNVTALSVVRYGGEALRLEQGGGDTPAGVRALVD
                     GNLAALRTGYPALPRRISGYALDALLPEHPGGPDPVRAFCGSEGTLAVVTEATVRLVEA
                     PPARALAVLGYADESAAAEAAPGLLPYGPLTVEGMAADLVRQPAGLPRGAAWLFVETGG
                     RTPTEARAHAERVLRAADALDAAVVTDPAGQRALWRIREDAAGTATRMPDGTEAWPGWE
                     DCAVPPARLGRYLRDFRALLAAHGLRGTPYGHFGDGCIHVRIDFDLLSGDGVARFRRFS
                     EEQADLVVAHGGSLSGEHGDGQARAELLPRMYGDELVALFGRFKDLWDPDGGLNPGVLA
                     RPARLDENLRFAVLPRRPVDAAFGYPHDGGDFAGAVRRCVGVAKCRTTEATGADVMCPS
                     FRATGEEAHSTRGRARLLHEMLAGEIVTDGWRSEEVRDALDLCLSCKGCRVDCPVGVDM
                     ATYKAEFLHHHYRGRLRPAAHYALGRLPRWLRLAAPFARPLNALARLRPVAALAKRLAG
                     ITPERTLPVLAAETFTRWLRRHSRRPASAGVVALWPDTFTEHLSPEVGRAAVRVLEDAT
                     GRAVRPAGPGVCCGLTYVSTGQLDAARAVMRRTLDRVRLPDGGPVVVLEPSCAATLRTD
                     LPELLPDDPRAGRLAAAVRTLAQYLEEYAPDWSPPRVDRPAAGQTHCHQHAVLGDAAER
                     RLRERMGLTGGLSGGCCGLAGNFGFEKGHWEVSVACAEERLLPALREAGPGTELLADGF
                     SCRTQIEQLAGRRARHLAEVIAERLPENAVTDRAR"
     gene            complement(7174..8058)
                     /locus_tag="EES43_RS16605"
                     /old_locus_tag="EES43_16410"
     CDS             complement(7174..8058)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003967204.1"
                     /locus_tag="EES43_RS16605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16410"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_124269437.1"
                     /transl_table=11
                     /translation="MTSGPSSGRPVELRHLRAFLAVADELNVTRAAARLRLTQPAVSRT
                     LAALERRLGVRLVDRSTHHLALTPEGVAFRDKAAFAIAAFDEALDSGRLRRWPLRLGHA
                     WSAFGPYTTPLLRTWQERHPHTPLELLRIDDRTAGLTRGEVDAALLRGPVDAPGLVTEV
                     LFIEKRVAAVTSDGPLAARASLSLADLAAGPVVLNTVSGTTTPGLWPPHARPTATLTVA
                     NTDDWLTAIAAGRGSGISAASTAVMHPHAGVAYVPLDDAPGVPVLLARRDGPGHPALPG
                     LAALAREIIARGR"
     CDS             8153..8215
                     /gene="allorf_3773390_3773452"
                     /locus_tag="allorf_3773390_3773452"
                     /protein_id="allorf_3773390_3773452"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNLPVRRAVPPAASPSCSPS"
     CDS_motif       8153..8191
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNLPVRRAVPPAA"
                     /locus_tag="allorf_3773390_3773452_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8192..8215
                     /prepeptide="core"
                     /locus_tag="allorf_3773390_3773452_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.10"
                     /molecular_weight="591.6"
                     /monoisotopic_mass="591.3"
                     /core_sequence="SPSCSPS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLPVRRAVPPAA"
                     /leader_location="[8152:8191](+)"
                     /alternative_weights="609.6"
                     /alternative_weights="627.7"
                     /alternative_weights="645.7"
     gene            8229..9227
                     /locus_tag="EES43_RS16610"
                     /old_locus_tag="EES43_16415"
     CDS             8229..9227
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1166: transporter,
                     EamA family"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018553153.1"
                     /locus_tag="EES43_RS16610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16415"
                     /product="EamA family transporter"
                     /protein_id="WP_124269438.1"
                     /transl_table=11
                     /translation="MNDQHSGAEPAAASVAVPEAATALEVSGAASGEPGASGLRARAGR
                     RAALGPVALVVAGGLSVQFGSAVAALLMPKAGALGVVTLRLAAAALILLVVCRPKLRGH
                     SRADWGTVAAFGVAMGGMNTLFYQALDRIPLGIAVTLEVLGPLALSVFASRRLVNVVWA
                     GLALVGVVLLGGGGLDRLDPVGAAYALGAGAMWAAYIVFSARTGRRFPQADGLALAMAV
                     AAVLSLPLGVIESGAKLTVPSTLALGAAVAVLSSVLPYTLELMALRRLPAPTFAVMMSL
                     EPAIAATAGFLILHQALSATDALAVALVIGASMGAVRSRSGRRSRSGRRRE"
     CDS             9247..9354
                     /gene="allorf_3774484_3774591"
                     /locus_tag="allorf_3774484_3774591"
                     /protein_id="allorf_3774484_3774591"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTGAVPRSRAGRLSGVCAACAHSAARAVSPLHAGR"
     CDS_motif       9247..9303
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTGAVPRSRAGRLSGVCAA"
                     /locus_tag="allorf_3774484_3774591_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9304..9354
                     /prepeptide="core"
                     /locus_tag="allorf_3774484_3774591_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-4.40"
                     /molecular_weight="1567.8"
                     /monoisotopic_mass="1566.8"
                     /core_sequence="CAHSAARAVSPLHAGR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTGAVPRSRAGRLSGVCAA"
                     /leader_location="[9246:9303](+)"
                     /alternative_weights="1585.8"
     misc_feature    complement(9409..9423)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 14.13"
                     /tool="antismash"
     gene            9422..9643
                     /locus_tag="EES43_RS16615"
                     /old_locus_tag="EES43_16420"
     CDS             9422..9643
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126649.1"
                     /locus_tag="EES43_RS16615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16420"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_006126649.1"
                     /transl_table=11
                     /translation="MNLVRAWKDPEYRATLSEAPANPAGLVELADDQLDGVAGGTTWAC
                     ATVTLTVTVCSPTGTLCGSCSMGTRGCC"
     CDS_motif       9422..9541
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MNLVRAWKDPEYRATLSEAPANPAGLVELADDQLDGVAGG"
                     /locus_tag="EES43_RS16615_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9542..9643
                     /prepeptide="core"
                     /locus_tag="EES43_RS16615_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.40"
                     /molecular_weight="3056.6"
                     /monoisotopic_mass="3054.4"
                     /core_sequence="TTWACATVTLTVTVCSPTGTLCGSCSMGTRGCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNLVRAWKDPEYRATLSEAPANPAGLVELADDQLDGVAGG"
                     /leader_location="[9421:9541](+)"
                     /alternative_weights="3074.6"
                     /alternative_weights="3092.6"
                     /alternative_weights="3110.6"
                     /alternative_weights="3128.7"
                     /alternative_weights="3146.7"
                     /alternative_weights="3164.7"
     gene            9669..9911
                     /locus_tag="EES43_RS16620"
                     /old_locus_tag="EES43_16425"
     CDS             9669..9911
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126650.1"
                     /locus_tag="EES43_RS16620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16425"
                     /product="mersacidin/lichenicidin family type 2
                     lantibiotic"
                     /protein_id="WP_124269439.1"
                     /transl_table=11
                     /translation="MFVDIVRSWKDADYRLSLGSEAPAHPSGEGLTAITDEELTEINGA
                     GSGVLGTLGCCSCLPWYSGWTVCGLACDPGKPCKN"
     gene            10001..13315
                     /locus_tag="EES43_RS16625"
                     /old_locus_tag="EES43_16430"
     CDS             10001..13315
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071701.1"
                     /locus_tag="EES43_RS16625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16430"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_241192457.1"
                     /sec_met_domain="DUF4135 (E-value: 3.4e-90, bitscore:
                     301.4, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.9e-53, bitscore:
                     180.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDDASEHPTVRPDGVHLPWHRAATLSERLGGTPSRSDPVRGEKR
                     LAMWRELAPLTGERATLDARLAPLGVDAAELTALLGESDDSLAARTADEPDWHRTFRRW
                     WAEGMATTDAARRLDPDMGLLEVIRPLVEGAVHELDALVEERVRASDDPVMADPGHILD
                     VVRATAPAADLLGHVQRTLVLELNIARVEERLGGETPEERFSSYVELLRSQGNALALWD
                     EYPVLARLVVNQLRFWIDTRVELIDALVADLPALRGGLLPSPGPRRLERLEFGAGDKHR
                     RGRSVAMVEFDTGTLVFKPRSLAMDTAFDGLLAWVNRQQPPHDLARIGVLERGGHGWVE
                     QVDTTATTDAAGGDRYAWRLGALTSLLYLLHATDFHFENVLAAGEHPVLVDLEALLHND
                     KTAAVVKIDGETDIAAVTLADSVQSVGILPNHLLVRGEDGTFGLDVSGLAGHGGQLTPM
                     PVPTWEDSGTDRMRLVKRRMEMDAERNHPMTADGEPIDLVGRVDAFVDGFTHVYRLLEA
                     GRDELLDPAGPLAAFGSVRTRLIARPTHIYGRLLLESTHPDFLRDGLDHARSLARLAGG
                     HVEMPESREAMVQDEVAELTLGDIPMFTVDAESGTLRGGFDGRPIGTRYPPLAAVRERL
                     AALGDADLAFQERVIRSCVAATAMGDSDARWPNWHRPRLDGAADPGDFAEEALRLARRL
                     GDLCVRDEHGLGWIGLDLVDEKYWQYAPAPIGLYTGTAGIAHALDAVAAVTGDEATGEL
                     ARAAFDQVAKRSVLIAETLASLAKKPGAAEFGIGAFGPFGGAVYALAHAAVRHDRPDYA
                     EAAAALLPAIDELVEEDPLLDVVSGSAGAILALLALEKARPAAGAARIAARCAERLLAT
                     RQECAEGWGWATPINPEAPLAGFSHGASGIAYALARLDAVAPRPEYGEAVRNALRYERT
                     VFDPELRTWRDLRPANLGGRTVMNAWCHGAPGIALARDAFQGLGTAADLADLVESDRHT
                     AVLAAVSTGLDLDPVSGLGNHSLCHGDVGNLLIIEASARADREPEVAGLLPRVWNTLLH
                     EGRENGWLCGVPKGVETPGLMTGLAGIAWGLARKAAPERVPDLLTLAAPAGPGGTP"
     gene            13312..13821
                     /locus_tag="EES43_RS16630"
                     /old_locus_tag="EES43_16435"
     CDS             13312..13821
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="EES43_RS16630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="EES43_16435"
                     /product="hypothetical protein"
                     /protein_id="WP_124269440.1"
                     /transl_table=11
                     /translation="MTGGPAPAAPPDGALADGVYRPSMVAAYRANPRGAARTGFHPERM
                     RPRWRWALAGALLLAATVAAGLVVRVPVGPTGTLAGADGRRGVLAFPGFSPPAKGSDVL
                     LRVDGRALEGRVEDFRAGQGGARVTMLLVELPDGVADGLEEGASVVLDQGTRPLLMDIW
                     DGRGDQ"
     gene            13818..15965
                     /locus_tag="EES43_RS16635"
                     /old_locus_tag="EES43_16440"
     CDS             13818..15965
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071703.1"
                     /locus_tag="EES43_RS16635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16440"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_241192458.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.7e-35, bitscore:
                     119.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATRRRVPVRLQSSSVECGVAALAMVLGHHGRATPVAELRDRMV
                     LSRDGASAAAIARQARELGMRVRAFRAEPEALRGLALPLIAHWGMNHFVVIERFTRRGV
                     DIVDPASGRRRITYAELDTSFTGVALELEPTDDLERRDAVEAGLWSFVRPFLPRSVSVV
                     SAVIGASAALTLLGLLPAFLTAYVVDRVLPGRSEGTLLILAAGLVAYTVSHALTTLARA
                     ELLLWLQTRMDWSMMGTFLRHLMSLPYKFFQLRTGGDLLVRVSSMTYVRDAVSSQLLAV
                     LLDVALLGVYLVVIGFTSMLFVGAILAVAAVQLAVMFASARTAQRLTERELQALGEAQS
                     TLLEAVTGAETVKSAGAEHVVVRRWSEKFTEQLESSVRRSRLDNAIDGVLGMLSTASPL
                     LMLVLGAYLVFSDALSLGTMLALIALAGAALAPVAQLGRGIKTFQTIRVHLDRLRDVID
                     EPPESLGQGEGKADLSEPITLSDVSFRYSGDGPEALSGISLTVRPGEKIAIVGASGSGK
                     STLARLILGLYDPTEGEITYGSTPLTELDLGHLRRQCGVVTQDADIFSGSVLTNIALVV
                     PDATLDEVVAAARLAAVHDDITRMPMGYETILGEGGNGLSGGQRQRVALARAVVHRPRV
                     LLLDEATSHLDATTEAVVHANLSELDCTRIVIAHRLSTVRDADRILVIDRGRIVEDGDH
                     GQLVARGGAYAALVGQQLVHD"
     gene            16018..16602
                     /locus_tag="EES43_RS16640"
                     /old_locus_tag="EES43_16445"
     CDS             16018..16602
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126654.1"
                     /locus_tag="EES43_RS16640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16445"
                     /product="multidrug transporter"
                     /protein_id="WP_241192459.1"
                     /transl_table=11
                     /translation="MTSTTRTRAALLKRLRTLTLLEAANIALIGWAVFAALGAPFSPAN
                     AAGYGLVAVLLIVGSAYWALKLRQLRTGARKPPLIGLFWWLRPLCALALAAGLAVLAVA
                     APGRPPSAWVPGLVLYGLALAEYVNYFHRQLMHDTRADWRRLLRTRRPRRSHLAEDLRT
                     HRDDRVRTSGPHGRARRRPARQPRETEERCS"
     gene            16599..17549
                     /locus_tag="EES43_RS16645"
                     /old_locus_tag="EES43_16450"
     CDS             16599..17549
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126655.1"
                     /locus_tag="EES43_RS16645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16450"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_124269441.1"
                     /transl_table=11
                     /translation="MTPPEAKGASAPAGGLPIEIAALSKRYRDTWAVEDLSFTVAPGRV
                     TGFLGPNGAGKTTTLRMLLGLTAPTSGTATVGGRRYRDLAQPLATVGAMLDESGAHRRR
                     TGRDHLRVQCAATGLPARRADEVLDRVGLLRAGRKRYEEYSLGMRQRLNLAQALLGDPP
                     VLVLDEPANGLDPEGIAWMRALLRNLAAEGRTVLVSSHLISEVEQTADDLVIISRGRLV
                     AEGSSREIAGRVRGEARVRVRSSRPAELAAALAAAGATVSPPAGDGLLIVGGLGTAAVA
                     AVAAGHGGELYELAEEAPDLEQAFLRLTQGKAEIR"
     gene            17549..18427
                     /locus_tag="EES43_RS16650"
                     /old_locus_tag="EES43_16455"
     CDS             17549..18427
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006126656.1"
                     /locus_tag="EES43_RS16650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16455"
                     /product="ABC transporter permease subunit"
                     /protein_id="WP_241192669.1"
                     /transl_table=11
                     /translation="MGLIGSELLKVRTLRTWWIAGLCMAVAAVLPALWNSWQAHTFMQP
                     FEDYLAGAVLTPREDMSAEQVGAMRDLWERQSAPDRIAAALYTSGQTAGLLLAGVLGVL
                     LVTNEYQYRTLTATFLAVPRRGRVIAAKLVAVLVCCAGLWLVATAGGLVVGGVFLASQG
                     AGPGLGDGDVAGAVLLNLAAYLVWGVFGFGLGALIRSQTAATVTAAVLYFLSSVVVAFA
                     FQAVHDLVLEEDWVLQAQVLLPGVASQIMTTPGELFSGAPAAWTGAVVLVAYGLLGGLT
                     GTLLLRRRDVT"
     gene            complement(18581..19543)
                     /locus_tag="EES43_RS16655"
                     /old_locus_tag="EES43_16460"
     CDS             complement(18581..19543)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010071705.1"
                     /locus_tag="EES43_RS16655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16460"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_241192460.1"
                     /transl_table=11
                     /translation="MIHTPRAGLPSGPAPHTAWPGPASAPPAAEAAPVRTADVLPEPFF
                     GVLGQLSVRGTTLSVTSPVRRAVLTACLLRFGQPIGIAEFSEILWDEPPVSATANLRSH
                     VTGLRRDLDEVEPGLGERVRTYRGGQCGYGLEIAAEEFDLPHFTAAVQRGRNWLLAGSH
                     EAAVGALEQAVGLWRGPFGQDLPPTRWFNAHIAGLNNIRFDAYQDLFTASVLAGRTSML
                     AYRIESVIAEAPYRQHLWELLAAVHCLHGDAVGTLSVVKRCQRLFAEDLGLDLPPGIEA
                     MRSAALNWDREEALRLVASRAQVAAERCQCRRPPRTLPS"
     CDS             complement(19845..19994)
                     /gene="allorf_3785082_3785231"
                     /locus_tag="allorf_3785082_3785231"
                     /protein_id="allorf_3785082_3785231"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MVFCERAGVRAARQGGAAGQGGADTGRCGGPPEQVGASSRTEAAN
                     PTSQ"
     CDS_motif       complement(19959..19994)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MVFCERAGVRAA"
                     /locus_tag="allorf_3785082_3785231_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(19845..19958)
                     /prepeptide="core"
                     /locus_tag="allorf_3785082_3785231_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.10"
                     /molecular_weight="3376.5"
                     /monoisotopic_mass="3374.6"
                     /core_sequence="RQGGAAGQGGADTGRCGGPPEQVGASSRTEAANPTSQ"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MVFCERAGVRAA"
                     /leader_location="[19958:19994](-)"
                     /alternative_weights="3394.5"
                     /alternative_weights="3412.5"
                     /alternative_weights="3430.5"
                     /alternative_weights="3448.6"
                     /alternative_weights="3466.6"
     misc_feature    20006..20015
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.02"
                     /tool="antismash"
     gene            20069..20953
                     /locus_tag="EES43_RS16660"
                     /old_locus_tag="EES43_16470"
     CDS             20069..20953
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020207461.1"
                     /locus_tag="EES43_RS16660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16470"
                     /product="TIGR03084 family metal-binding protein"
                     /protein_id="WP_124269443.1"
                     /transl_table=11
                     /translation="MSDAAAVIDDLREESAELEAMVRELAPERWNGPTPAAGWTLAHQI
                     AHLTWTDEVALLAATEPDRFGEEVAKALAAPDSFVDEAAGELVAALSPDALLARWRAGR
                     GRLDAVLREAPRGARIPWYGPPMSVASMATARLMETWAHGQDVADALGVARRPTARLRH
                     VARIGVRARDYAYAVRGIAAPEEEFRVELHTPHGETIAFGPTGAAQRVTGPLLDFCLLV
                     TQRAHRLDLAVTAEGREADQWLGIAQAFAGPPGPGRLPRGEWPERADRPEPGGRSEPGG
                     RSEHTERGERPGA"
     gene            20950..22674
                     /locus_tag="EES43_RS16665"
                     /old_locus_tag="EES43_16475"
     CDS             20950..22674
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007454021.1"
                     /locus_tag="EES43_RS16665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="EES43_16475"
                     /product="acyclic terpene utilization AtuA family protein"
                     /protein_id="WP_241192461.1"
                     /transl_table=11
                     /translation="MSGAPLRVGNASGFYGDRFDALREMLTGGPLDVLTGDYLAELTML
                     ILGRNRLKGPGRGYAATFLRQLEEGLGLAHERGVKIVVNAGGLDPAGLADAVRALAERV
                     GVPARVGHVEGDSLPVPDGFLTANAYLGGGGIAACLRAGADVVVTGRTTDAALVTGPAA
                     ARFGWGPDDLDALAGAVVAGHVLECGTQATGGNYAFFGEHDVRRPGFPVAEIHADGSCV
                     ITKHDGTGGVVDVGTVTAQLLYETDGARYAGPDATARLDTVRLTRLGPDRVRVDGVRGE
                     APPPTLKAGLTRLGGWRNEVVFVLTGLDVEAKARLVRAQFTDALERSGARGPAEVRWEL
                     ARTDHADAGTEERAAALLRLVVRDRDADAVGRAVSGAAVELALGSYPGFHVTAPPGPGA
                     PYGVFEARYVPAADVAHVAVRPDGSREAVDHPVRTRPLAPVDEPPLPEPYPAGPTRRAP
                     LGLIAGARSGDKGGDANVGVWVRDDDAWRWLAHELTVERFRELLPETAGLTVVRHVLPN
                     LRALNFTVRGLLGEGVAARARFDPQAKAVGEWLRSRWLPVPVPLLERAHAPSPEVTV"
     misc_feature    22849..22864
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.92"
                     /tool="antismash"
     misc_feature    complement(23123..23138)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.3"
                     /tool="antismash"
ORIGIN
        1 gtccacgtcc ggcagccggt ccaggagcac ttcgatcccg gtgcgggcga tgacctcggc
       61 ggtctcctgg gccgggaagg ggcagcggtg ctcgccgtgg ccgaaggaga ggaaggcgtt
      121 gttgccgccg gtcagcgccg aggcgtgggt gcgtatctgc ggatcgccgt tggcggcggc
      181 gatgccgagg atcagcaggt cgccggcgcg gacgtggcgt ccgccgaggt gggtgtcgcg
      241 ggcggcccag cggccggcca cgttctgggt gggggtgtcc tcccagagca cttcgttcat
      301 cgcctcggcg acgctgtgcc ggccaccgga gagcgaggcg gcgaaccggt cgtcggtgag
      361 catcaggcgc agtgagttgc cgatccagtc ggcggtcggc tggtgtccgg ccgccatcat
      421 gaccatgagg tcctgggcga tctcctcgtc ggtgaagccg ccctcggcgg tgagcatccg
      481 ggtggcgacg tcgtcgcccg gcgcggcgtg cttgtcggcg agcagctggg ccatggaggc
      541 ggcgagccgc cgctgtccgg cgagcgcccg ctcgcggccg tcgacgatgt cgttgatcgc
      601 gccgacgagg acgtgggtca tcgcgtcgtc gaagccgtag atccgggcca gcacgagggc
      661 ggggagcacc ttcgcgtact cggcgatgat ctcggtggcg cccttggtgc agaactggtc
      721 gatcagctcg tccgcgaact cctcggcgta gcgcttgagg gagaacgggt cgacgccctc
      781 cagcgcgtcg ctgatcatcc tggcgcggac gctgtggcgt tcgccgacgg tgtagaggat
      841 cgagggctgc ttgcgcccga tcatcggcag cagcggccag tcgtccggga tgcggtccca
      901 ctggttccac aggtcggagt cgcggctgaa gagggccggg tcgccggtga cctggtggag
      961 ttcgcggtag ccgaggacca gccaggcggg cacgtcgccg tccagcacga cgggggccac
     1021 ggccccgtgg tcgcgccgca ggtcgcggta gtgccgcacg gggtcgctct ggaagcgggg
     1081 cccggacagc gggacggagc cgtgggggac ggggcagccg gagacggcgt tcacggcgcg
     1141 ggctccgggg tcggtcgggc cgaggcgagg gccgcccgcg gcgaccgggc ggcggacagc
     1201 ttgtgcaggt gctcgacgag tgtgatgagc acgtacttgc tggaggaccg gtcgcgggcg
     1261 tcgcactcga cgagcggcac gtcgtccgag aggtccaggg cctcgcggat ctgctgctcg
     1321 gagtggagcg ggccgccgaa gtcgttgcag gcgacgatga acggcgtgcc gtggtgctcc
     1381 agccggtcga tcgcgtacca ggagtcggcg agccgccggg tgtcgacgag gacgaccgcg
     1441 ccgagcgtgc cggagaacag ccggtcccac aggaaccaga agcgctcctg gccgggagcg
     1501 ccgaagaggt agagcacgga ccgcgcgtcg agggtgatgc ggccgaagtc gaacgccacg
     1561 gtggtggacg tcttggcctg gacgccgtcg aggtggtcga cggcctcgcc cgcgcgggtc
     1621 atggtctcct ccgtgttgag cggacggatc tcgctcacgg atcggaccat ggtggtcttg
     1681 ccgaccccga agccgccgac gacaacgatc ttgagtccgt tgtcggccgt cgcgctcagg
     1741 gcggcgcggt cagaggttgc ggagtccaac gagcacctgt tccaggatgt cggggtcggg
     1801 gagccggtcc gcgacccggg ctgtacgggg gtggcgggcg ctgatccggc cggtgtcgag
     1861 caggtcgcac agcatgatgc ggacgatgct gaccggcagg ccgagggtgg ccgagatctc
     1921 gacgaccgcg gtcggtccgg cgcacatccg caggatcgcg acgtgctccg actgcatgcc
     1981 gggcgtcgga tcgcattcgg cgacgacgag cgtcaccagg tcgaaggagg cggagtcgga
     2041 ccggctgcgg cccccggtga gggtgtacag ccggtcggga tcgtcgtcgc ggcccggacg
     2101 ggagcggggc ggcgtcgtca tacggccggg gtttccgccg ccgtcgcggt cgcggagggc
     2161 gatcgcggcg gggcgacgag gtgttcgccg agctgttcga cgagctcgct catgttgtgg
     2221 ccgaccaggc cgacgtcgga gtcctcgtcg gcgacgacgg ccaggtgcgc gcccgcgccc
     2281 gcctcgacga tgaacagcac gccgccgtag aactcggcca tcgcggagcg tacgccgccg
     2341 gtgccgtcgc cgaactcgat ggacgcgccg tgcgacaggc tctggattcc ggcggagatc
     2401 gcggccagct ggtcggcctg gtcgacggac agctcgggcg tgcggcacag cttgaggccg
     2461 tcgcgggaca ggacgagcgc gtgccgggtg ccgggcgtgc ggtcgagcag cccctccagc
     2521 agccagttga gcttctcgtc ggtggtcgcg gtcatcgggt gttgccttcc gggagcgggg
     2581 tgttggctcg tacggccttg ctgaaggtgc tgaagcgggc tgcctggacc ttcgggtcgg
     2641 tggtggtgcg gcccgggtcg gtttcggctc ggccggaggc ggcgttgccg gtacgggact
     2701 cggcggcggc cagggtccgg ccgcggcggc gcttgggcag gccgctctcg ccgaacgcgg
     2761 gcacgccgcc ggtggcttcg gaggcgctgc cgtccggcgc tgtgccggcg gagtcctggt
     2821 ggccgtcgcc gggcgcgggc cgggacgcct cggcggtcgc ggagggccgc gcggccggtg
     2881 cgtgggcggg ctcgggctcg gcgggggcgg gctgccgcgc gggggtcgtg gtggccgcct
     2941 cgccctgcac acgggtcgcg gcgcgcgaga tgaggtcctg cgggagcatc atcagcgcgc
     3001 cggtgccgcc ccgggcggac ggccggaagg agacggtcag gccgtgcttg cgggccagcc
     3061 ggccgacgac ggcgaggccg agccgggtgc cggagaggtt ggtgaggtcc tggttctcgg
     3121 cggagacggc cttctcggcg cggcgcagct ggacctcgct catgacgagc ccgctgtcct
     3181 cgacggtgat gacgatgccg gccgggacct cctccacgta cacgtggacc tcggcggtgg
     3241 gcggcgagaa gttggccgcg ttgtccagga gttcggcgag cgcgtgcatg acgccctcgg
     3301 ccgcgtggcc cgcgatggcg acgtcgctcg tggagtgcag gcgcacccgc tggtagctgc
     3361 cgatgcggcc catcgcgccg cgcaggatcg actccatgac gatcggcttg gcccaacggc
     3421 gtccggagcg cgccccggtc agtacggcga tggagtcggc gagccggccc gcctgggcgg
     3481 tgcggtggtc caggtgcagc aggtcgccga ggacggactc gtccgcgtgc cggtgctcca
     3541 tctcgcgcag gtcggccagc atgctggtgg ccagggcctg catgcggccg gcggcgttgg
     3601 cgcaggcggc gacggcggcg gagcgctcgg tctcggcgcg ggtggcgcgg gcggtgagcc
     3661 gttcgacggc ggcgttcagc cgggcccgtt cggcggcggc ctcggcggtg agccgggtgg
     3721 actcggcgcg ggcctcggcc gcgagccgcg cggtctcggc ggaggcggcg cccttgatgc
     3781 gggcggtctc cgcggtgaag cgctgggcct cggcggagga ggccgagacc atgcgggagg
     3841 tctcggcggt gaaccgctcg gcgtcggcgg cccgccgggc gcgcagggtg cgggtggtcc
     3901 ccagggtgtg cgcggcgacg gcgacgcaca cgctcaccac gacggcggcg gcgcccgctc
     3961 cccaggccag cggggtcctc accgagtcgg gggccgcgat cacggcccac agggtcaggg
     4021 cgccggtggc ggctgccgag atcagcaagg cgagtgcggt gggccggaat gaggggcgca
     4081 atcggagtcc tcggtggcgg acggtgcggg ggcaggggcg aatcaggaca gtccgtcacg
     4141 agagtggaag atcgtgacaa ctggagctga taattcctgc tcaagtcttg gtcactatag
     4201 gagaattggc gatcagtttg ggaagttctg gtgggctttt atgtgtgact tgcccgcctt
     4261 catccgcccg catcccaaga gttcacgcgg ttcgacggca tcctgacgtc atggccgaac
     4321 accaccgacc gcgccccgga ccgcgtaccg gaaagcgacc cgccccgcgc accgggcctc
     4381 ccgccggacc ggaccccgcg ttcgtcccgg ccctgcgcgc cgccgtccgg ggcgagagcg
     4441 atttcggggc cgccgcgcgg gccctgctga cgatggacgc ctccaactac cgccgcgtac
     4501 cgctcggcgt cctcgccccg cgcgacgccg acgacatcgc cgccgctctg gccgtctgcc
     4561 gggagcacgg cgtcccggtc gtggcgcgcg gcggcggcac gtccatcgcc ggccaggcca
     4621 ccggcaccgg cctggtcctc gacctcaccc gccacctgag cgcggtcctc gacctggacc
     4681 cggccgcccg caccgccgtg gtccagcccg gcgtggtcct ggacgacctg cgggccgccg
     4741 ccgcaccgca cggactgacc ttcggcccgg acccctccac ccacagccgc tgcaccctcg
     4801 gcggcatgat cggcaacaac gcctgcggct cccactcggt cgcgtggggc accaccgcgg
     4861 acaacgtgac ggcgctgtcg gtcgtccggt acgggggcga ggcgctgcgc ctggaacagg
     4921 gcggcggcga caccccggcg ggcgtgcgcg ccctcgtgga cggcaacctc gcggcgctgc
     4981 gcaccggtta ccccgccctg ccgcgccgca tctccggcta cgcgctggac gccctgctgc
     5041 ccgagcaccc cggcggcccc gacccggtgc gggccttctg cggctccgag ggcaccctcg
     5101 ccgtggtcac cgaggcgacc gtgcgcctgg tcgaggcccc gcccgcccgc gccctggccg
     5161 tcctcggata cgccgacgag tccgccgccg ccgaagccgc ccccggcctc ctcccgtacg
     5221 gcccgctcac cgtcgagggc atggccgccg acctcgtacg ccaaccggcc gggctgccgc
     5281 gcggggccgc ctggctcttc gtcgagacgg gcggccggac cccgacggag gcgagggcgc
     5341 acgccgaacg cgtcctgcgc gccgccgacg ccctggacgc cgcggtggtc accgacccgg
     5401 ccgggcagcg ggccctgtgg cggatccgcg aggacgccgc cggcaccgcg acccggatgc
     5461 cggacggcac cgaggcgtgg cccggctggg aggactgcgc ggtgccgccc gcccggctcg
     5521 gccgctacct ccgcgacttc cgcgccctgc tcgccgcaca cggcctgcgc ggcaccccgt
     5581 acggccactt cggcgacggc tgcatccacg tgcgcatcga cttcgacctg ctgagcggcg
     5641 acggcgtggc ccgcttccgc cgcttctccg aggagcaggc ggacctcgtc gtcgcgcacg
     5701 gcggttcgct cagcggcgag cacggcgacg gccaggcacg ggcggagctg ctgccgcgca
     5761 tgtacgggga cgaactcgtc gccctcttcg gccggttcaa ggacctgtgg gacccggacg
     5821 gcggcctgaa ccccggcgtg ctcgcccgcc cggcccggct cgacgagaac ctgcgcttcg
     5881 cggtgctgcc gcgccgcccg gtggacgcgg ccttcggcta tccgcacgac ggcggcgact
     5941 tcgcgggcgc ggtccgccgc tgcgtcggcg tcgccaagtg ccgtacgacc gaggccaccg
     6001 gagccgacgt gatgtgcccg tccttccggg ctaccggcga ggaggcccac tcgacgcggg
     6061 gcagggcccg gctgctgcac gagatgctgg cgggcgagat cgtcacggac ggctggcgga
     6121 gcgaggaggt gcgggacgcg ctcgacctct gcctgtcctg caaggggtgc cgggtcgact
     6181 gcccggtggg cgtcgacatg gccacgtaca aggcggagtt cctgcaccac cactaccggg
     6241 gacggctgcg gcccgccgcg cactacgcgc tgggccgact cccccggtgg ctgcggctcg
     6301 ccgccccctt cgcccggccg ctgaacgcgc tggcccgcct ccgcccggtc gccgccctcg
     6361 cgaagcggct cgcgggcatc acgccggagc ggacgcttcc ggtcctggcc gccgagacgt
     6421 tcacgcggtg gctgcgccgg cactcccggc ggcccgcctc cgcgggggtg gtggccctgt
     6481 ggccggacac cttcaccgag catctgtcgc ccgaggtcgg ccgggcggcg gtccgggtgc
     6541 tggaggacgc gacgggccgc gcggtgcggc ccgccgggcc gggcgtgtgc tgcggcctca
     6601 cctatgtgtc gaccggccaa ctggacgcgg cccgcgcggt gatgcgccgc accctggacc
     6661 gcgtgcgcct cccggacggc gggccggtcg tcgtcctcga accgagctgc gccgccaccc
     6721 tccgcaccga cctgcccgaa ctgctccccg acgacccgcg cgccgggcgg ctcgccgccg
     6781 ccgtccggac cctggcccag tacctggagg agtacgcccc cgactggtcg ccgccgcgcg
     6841 tcgaccgccc ggccgccggc cagacgcact gccaccagca cgcggtgctc ggggacgcgg
     6901 cggagcgccg gctgcgcgag cggatggggc tgaccggcgg actgagcggc ggctgctgcg
     6961 gcctcgccgg gaacttcggc ttcgagaagg gccactggga ggtgtcggtc gcctgcgccg
     7021 aggagcggct gctgcccgcc ctgcgggagg ccgggcccgg gacggaactg ctcgcggacg
     7081 gcttctcctg ccgcacccag atcgagcagc tcgccggacg gcgggcccgg cacctcgcgg
     7141 aggtgatcgc ggaacggctg ccggagaacg ccgtcaccga ccgcgcgcga tgatctcgcg
     7201 ggccagggcg gccagccccg gcagcgccgg atggcccggc ccgtcgcggc gggccagcag
     7261 caccgggacg cccggggcgt cgtccagcgg cacgtaggcg accccggcgt gcgggtgcat
     7321 gacggcggtg gaggcggccg agatcccgct gccgcgccca gcggcgatgg cggtcagcca
     7381 gtcgtcggtg ttggcgacgg tgagcgtggc ggtgggccgg gcgtgcggcg gccacaggcc
     7441 gggggtcgtc gtgccggaga cggtgttcag gaccacgggg ccggcggcca ggtcggcgag
     7501 cgagagcgac gcgcgggccg ccagcgggcc gtccgaggtc accgccgcca ccctcttctc
     7561 gatgaacagc acctcggtga ccaggcccgg cgcgtccacc ggtccgcgca gcagcgccgc
     7621 gtccacctcg ccgcgggtga gcccggccgt gcggtcgtcg atccgcagga gttccagcgg
     7681 ggtgtgcggg tggcgctcct gccaggtgcg cagcagcggt gtggtgtacg ggccgaaggc
     7741 ggaccaggcg tgcccgagtc gcaggggcca ccggcgcagc cgcccggagt ccagcgcctc
     7801 gtcgaaggcg gcgatcgcga aggcggcctt gtcgcggaag gcgacgccct ccggggtgag
     7861 ggcgaggtgg tgggtggagc ggtcgacgag ccggacgccc aggcgccgtt ccagggcggc
     7921 gagggtgcgc gagacggccg gctgggtgag ccggagccgg gcggcggcac gggtgacgtt
     7981 cagctcgtcg gcgacggcga ggaaggcccg cagatggcgc agctcgaccg ggcggccgga
     8041 ggaaggtcct gaggtcatgc acgcggagca taacgggagc gcagtcggca tttcacggaa
     8101 ggcgcgacgg tctctacggt gaggagggag gcgtgcgcgg cggtgcggca tcgtgaacct
     8161 gccggtgcgc cgcgccgtcc cgcccgccgc ttccccgtcc tgttccccgt cctgacgaga
     8221 ggccacccgt gaacgaccag cacagcggcg cggaaccggc cgccgcatcc gtggccgtgc
     8281 ccgaggcggc gacggcgctc gaagtctccg gcgcggcctc cggcgagccg ggtgcgtccg
     8341 gcctccgggc ccgcgccgga cgccgggccg cgctggggcc ggtcgccctg gtggtggccg
     8401 gggggctgtc ggtccagttc ggctcggccg tcgccgcgct gctgatgccg aaggcgggcg
     8461 cgctgggcgt cgtcacgctg cggctggcgg cggcggcgct gatcctcctg gtcgtctgcc
     8521 gtccgaagct gcgcgggcac tcgcgggccg actggggcac ggtggccgcc ttcggcgtgg
     8581 cgatgggcgg catgaacacg ctcttctacc aggcgctgga ccgtatcccg ctgggcatcg
     8641 ccgtcaccct ggaggtgctg ggcccgctcg cgctctcggt gttcgcctcc cgccgcctgg
     8701 tcaacgtggt gtgggccggg ctcgcgctcg tcggggtggt gctgctcggt ggcggcggcc
     8761 tcgaccgcct cgacccggtc ggcgcggcct acgcgctggg ggcgggcgcg atgtgggccg
     8821 cgtacatcgt gttcagcgcg cgcaccggcc gccgcttccc gcaggcggac gggctggccc
     8881 tggcgatggc ggtcgcggcg gtcctctccc tgccgctggg cgtcatcgag tccggggcga
     8941 agctgaccgt gccctcgacg ctggcgctcg gcgcggcggt ggccgtgctc agctccgtcc
     9001 tcccgtacac cctggagctg atggccctgc gccgcctgcc cgcgcccacc ttcgccgtga
     9061 tgatgagcct ggagccggcc atcgcggcca cggcgggctt cctgatcctg catcaggcgc
     9121 tgtccgcgac ggacgcgctc gccgtcgccc tggtcatcgg ggcgagcatg ggcgcggtcc
     9181 gcagccggtc gggccgccgc agccggtcgg gccgccgccg ggagtgagcg gaccgccgcc
     9241 gcgcctttga ccggagccgt tccgcgcagc cgcgcggggc ggctctccgg cgtatgcgcg
     9301 gcctgtgcgc acagcgccgc ccgcgcggta tccccgctcc atgccggccg ctgaggatgg
     9361 cacccggaac ccggccccac cggccggatt cccatcccca gcgagaggag gtgacagaca
     9421 aatgaacctt gttcgcgcat ggaaggaccc ggagtaccgg gcgaccctca gcgaggctcc
     9481 cgccaacccg gccggtctcg tcgagctggc cgacgatcaa ctcgacggcg tcgcgggcgg
     9541 aaccacgtgg gcgtgcgcca cggtcacgct gaccgtcacg gtgtgctccc cgaccgggac
     9601 gctctgcggc agttgcagca tgggcacgcg cggctgttgt tgagcctgcc ggatacgtac
     9661 gaggagtgat gttcgtggac atagtccggt cctggaagga cgccgactac cggttgtccc
     9721 tcgggagtga ggcccccgcc catccgtcgg gcgagggtct caccgcaatc accgacgagg
     9781 agctgaccga gatcaacgga gcgggctccg gggttctcgg cactctcggg tgctgctcgt
     9841 gcctgccgtg gtactcgggc tggaccgttt gcggtctcgc ctgcgacccc ggcaagccct
     9901 gcaagaacta gcagcgtacc gaagaaacgg cgtgaccggc aggggcgggc gtccgcgcgc
     9961 ccccgccggt catgttcatg ccccaagaag gaagagcgga atgcctgacg acgcaagcga
    10021 gcaccccacc gtccggccgg acggggtcca cctcccgtgg caccgagccg ccacgctgag
    10081 cgagaggctc ggcgggactc cgtcgcggtc cgacccggtg cggggcgaga agcgcctggc
    10141 catgtggcgg gaactggcac cgctgaccgg cgagcgcgcc accctggacg cacggctggc
    10201 accgctgggc gtcgacgccg ccgaactgac cgccctgctc ggcgagagcg acgactccct
    10261 cgccgcccgc acggccgacg aacccgactg gcaccgcacg ttccgccgct ggtgggccga
    10321 gggcatggcc acgacggacg ccgcccgccg cctcgacccc gacatgggcc tcctggaagt
    10381 gatccgcccc ctcgtcgagg gcgccgtcca cgaactggac gcgctcgtcg aggaacgcgt
    10441 acgggccagt gacgaccccg tcatggccga ccccggacac atcctcgacg tggtccgcgc
    10501 gacagccccg gccgccgacc tgctcggcca cgtgcagcgc acgctggtcc tcgaactcaa
    10561 catcgcccgc gtcgaggagc gcctcggcgg cgagaccccc gaggagcgct tctcctccta
    10621 cgtcgagctg ctgcggtcac agggcaacgc cctcgccctg tgggacgagt acccggtcct
    10681 ggcccggctg gtggtgaacc agctccgctt ctggatcgac acgcgggtcg agctgatcga
    10741 cgccctcgtc gccgacctgc ccgcgctgcg cggcggcctg ctcccctccc ccggaccccg
    10801 gcggctcgaa cgcctggagt tcggcgcggg cgacaagcac cggcgcggcc ggtccgtcgc
    10861 catggtcgag ttcgacaccg gcaccctggt cttcaaaccc cgctcgctgg ccatggacac
    10921 cgcgttcgac gggctcctgg cctgggtcaa ccggcagcag cccccgcacg acctggcccg
    10981 gatcggcgtc ctggagcgcg gcggccacgg atgggtcgaa caggtcgaca ccaccgcgac
    11041 caccgacgcc gccggcggcg accgctacgc gtggcggctg ggcgcgctga cctcgctgct
    11101 ctacctcctg cacgccacgg acttccactt cgagaacgtg ctggccgccg gcgagcaccc
    11161 ggtcctcgtc gacctggagg cgctgctgca caacgacaag accgccgccg tcgtcaagat
    11221 cgacggggag acggacatcg cggcggtcac cctcgccgac tccgtccagt cggtgggcat
    11281 cctgcccaac cacctgctgg tgcgcggcga ggacggcacc ttcggcctgg acgtcagcgg
    11341 actggccgga cacggcggcc agctcacccc catgccggtg ccgacctggg aggacagcgg
    11401 caccgaccgc atgcggctgg tcaagcgccg gatggagatg gacgccgagc gcaaccaccc
    11461 gatgaccgcc gacggcgaac cgatcgacct ggtcggccgg gtcgacgcgt tcgtcgacgg
    11521 gttcacccac gtctaccggc tgctggaggc gggccgggac gaactgctcg acccggcggg
    11581 cccgctggcc gccttcggct ccgtgcggac ccggctcatc gcccggccca cgcacatcta
    11641 cggccgcctg ctgctggaga gcacccaccc cgacttcctg cgcgacggac tcgaccacgc
    11701 ccgctccctc gcccggctgg ccggcggcca cgtcgagatg ccggagtcgc gcgaggcgat
    11761 ggtccaggac gaggtcgccg agctgacgct cggagacatc cccatgttca ccgtcgacgc
    11821 ggagtccggg accctgcgcg gcggattcga cggccggccg atcggcaccc gctacccgcc
    11881 gctcgccgcc gtacgggaac gcctcgccgc cctcggggac gccgacctcg ccttccagga
    11941 gcgcgtcatc cgctcgtgcg tcgccgccac cgccatgggc gacagcgacg cgcgctggcc
    12001 caactggcac cgaccccgcc tggacggcgc cgccgacccg ggcgacttcg ccgaggaggc
    12061 cctgcggctg gcccgccggc tcggcgacct gtgcgtccgc gacgaacacg ggctcggctg
    12121 gatcggactg gacctggtcg acgagaagta ctggcagtac gcgcccgctc cgatcggcct
    12181 ctacaccgga acggccggca tcgcgcacgc cctggacgcc gtcgccgccg tcaccggtga
    12241 cgaggcgacc ggcgagctgg cgcgggccgc cttcgaccag gtggcgaagc gctcggtgct
    12301 catcgccgag acgctggcgt ccctggcgaa gaagccggga gccgccgagt tcggcatcgg
    12361 cgcgttcggc ccgttcggcg gcgcggtgta cgccctggcg cacgccgccg tacgccacga
    12421 ccgccccgac tacgccgagg cggccgccgc cctgctgccc gccatcgacg aactcgtcga
    12481 ggaggacccg ctcctggacg tcgtctccgg ctcggcgggc gcgatcctcg ccctcctcgc
    12541 gctggagaag gcccggcccg ccgccggagc ggcccggatc gcggcgcgct gcgccgagcg
    12601 cctgctcgcc acccggcagg agtgcgccga gggctggggc tgggccaccc ccatcaaccc
    12661 cgaggcgccg ctggccgggt tctcgcacgg ggcctccggc atcgcgtacg cgctcgcccg
    12721 gctcgacgcc gtcgccccgc gcccggagta cggcgaggcc gtccggaacg cgctgcggta
    12781 cgagcggacc gtcttcgacc cggagctgcg cacctggcgc gacctgcgcc ccgccaacct
    12841 cggcggacgc accgtcatga acgcctggtg ccacggggcc ccgggcatcg cgctggcccg
    12901 cgacgcgttc caggggctcg ggaccgccgc cgacctggcc gacctggtcg agagcgaccg
    12961 gcacaccgcc gtcctcgccg ccgtctcgac gggcctcgac ctcgacccgg tgtccgggct
    13021 gggcaaccac agcctgtgcc acggggacgt gggcaacctg ctcatcatcg aggcgagcgc
    13081 gcgagccgac cgggaacccg aggtcgccgg cctgctgccc cgggtgtgga acacgctcct
    13141 gcacgagggc cgggagaacg ggtggctgtg cggcgtcccg aagggggtgg agacgcccgg
    13201 cctgatgacc gggctggccg gcatcgcctg ggggctggcg cgcaaggccg cccccgagcg
    13261 ggtgccggac ctgctgaccc tggccgcccc cgccgggccg ggagggacgc cgtgaccggc
    13321 gggcccgcgc cggcggcccc gccggacggc gcgctcgcgg acggcgtcta ccggccgagc
    13381 atggtggcgg cctaccgcgc caacccgcgc ggcgcggccc gtaccggctt ccaccccgaa
    13441 cggatgcgcc cgcgctggcg gtgggccctg gccggggccc tgctgctcgc cgccacggtg
    13501 gcggcgggcc tcgtggtgcg ggtgccggtc gggccgaccg gcaccctggc cggggccgac
    13561 ggacgccggg gcgtgctcgc cttccccggc ttcagcccgc cggccaaggg cagcgacgtc
    13621 ctgctgcgcg tcgacggccg ggccctggag ggccgggtcg aggacttccg ggccgggcag
    13681 ggcggagccc gggtcaccat gctgctcgtc gaactccccg acggcgtcgc cgacgggctg
    13741 gaggagggcg cgagcgtcgt cctcgaccag ggcacccgcc cgctgctcat ggacatctgg
    13801 gacggaaggg gcgaccagtg accgcgacgc gccgcagggt gcccgtacgg ctccagtcca
    13861 gctcggtcga gtgcggcgtc gccgcgctcg ccatggtgct cggccaccac ggacgcgcca
    13921 ctcccgtcgc ggagctgcgg gaccggatgg tgctctcccg cgacggggcg agcgcggcgg
    13981 ccatcgcccg ccaggcgcgt gaactgggca tgagggtgcg ggccttccgc gcggagccgg
    14041 aggccctgcg ggggctcgcc ctgccgctga tcgcgcactg gggcatgaac cacttcgtcg
    14101 tcatcgagcg cttcacccgc cgaggcgtcg acatcgtcga cccggcgtcc gggcggcggc
    14161 gcatcacgta cgcggagctg gacacgtcct tcaccggggt ggcgctggag ctggagccga
    14221 ccgacgacct cgaacgccgc gacgccgtcg aggcggggct gtggtccttc gtccggccct
    14281 tcctgccccg ttccgtctcc gtcgtctccg ccgtcatcgg ggcctcggcc gcgctcacgc
    14341 tcctcggact gctcccggcc ttcctgacgg cgtacgtcgt cgaccgcgtc ctgcccggcc
    14401 gcagcgaggg caccctgctg atcctggcgg cgggcctcgt cgcgtacacc gtgagccacg
    14461 ccctgacgac gctggcgcgg gccgagctgc tgctgtggct ccagacccgc atggactggt
    14521 cgatgatggg cacgttcctg cgccatctga tgtccctgcc gtacaagttc ttccaactgc
    14581 gcaccggggg cgacctgctc gtacgggtgt cgagcatgac gtacgtccgc gacgccgtct
    14641 ccagccagct cctcgcggtc ctcctcgacg tcgccctgct gggcgtctac ctcgtggtga
    14701 tcggcttcac gtcgatgctc ttcgtcgggg cgatcctcgc cgtggcggcc gtccagctcg
    14761 ccgtcatgtt cgcctccgcg cggaccgcgc agcggctgac cgaacgcgaa ctccaggcgc
    14821 tcggcgaggc gcagagcacg ctcctggagg cggtgaccgg tgccgagacg gtcaagtcgg
    14881 ccggcgcgga gcacgtggtg gtgcgccggt ggtcggagaa gttcaccgag cagttggagt
    14941 cctccgtacg ccggagcaga ctggacaacg cgatcgacgg cgtcctcggc atgctgagca
    15001 ccgcctcgcc gctgctcatg ctggtgctcg gcgcgtacct cgtgttcagc gacgccctgt
    15061 cgctggggac gatgctcgcg ctcatcgcac tggccggggc cgcgctcgca ccggtcgccc
    15121 aactcgggcg cgggatcaag acgttccaga ccatccgggt ccacctcgac cggctgcgcg
    15181 acgtgatcga cgagccgccg gagtccctgg gccaggggga ggggaaggcg gacctgagcg
    15241 agccgatcac cctgagcgac gtcagcttcc gctactccgg ggacgggccg gaggcgctgt
    15301 cgggcatctc cctcaccgtc cgtccgggcg agaagatcgc catcgtcggc gcgagcggtt
    15361 cggggaagtc gaccctggcc cgcctcatcc tcggcctcta cgacccgacc gagggggaga
    15421 tcacctacgg ctccacgccg ttgaccgaac tggacctcgg ccacctgcgc cgccagtgcg
    15481 gtgtggtcac ccaggacgcg gacatcttca gcggctcggt gctgaccaac atcgcgctgg
    15541 tcgtgcccga cgccaccctg gacgaggtcg tggcggcggc ccgcctcgcc gcggtccacg
    15601 acgacatcac ccgtatgccg atggggtacg agacgatcct cggcgagggc ggcaacggcc
    15661 tctccggagg gcagcggcag cgcgtggcgc tggcccgcgc cgtcgtgcac cggccgaggg
    15721 tcctgctgct ggacgaggcc accagccacc tcgacgcgac caccgaggcg gtggtgcacg
    15781 cgaacctgtc ggagctcgac tgcacccgca tcgtcatcgc ccaccggctg agcaccgtgc
    15841 gcgacgccga ccgcatcctg gtgatcgacc gcggtcggat cgtcgaggac ggcgaccacg
    15901 ggcaactcgt cgcgcgcggc ggcgcgtacg cggccctcgt cggacagcaa ctggtccatg
    15961 actgacggat cgccgccaac ggccccgcgt tccggcgcgg gccgggatgc tgggagcgtg
    16021 acctcgacga cgcggacccg ggcggcgctc ctgaagcggc tgcgcacgct gaccctcctg
    16081 gaggcggcga acatcgccct gatcggctgg gcggtgttcg cggccctcgg cgcgcccttc
    16141 agcccggcga acgccgccgg ttacggactg gtcgccgtac tcctgatcgt cggctcggcg
    16201 tactgggcgc tgaagctgcg ccaactgcgc accggggcgc gcaagccgcc cctgatcggg
    16261 ctgttctggt ggctccggcc gctgtgcgcc ctcgccctgg cggccggcct cgcggtcctc
    16321 gccgtcgcgg cgccgggccg tccgccgtcc gcatgggtcc ccggcctggt gctgtacggg
    16381 ctggccctgg cggagtacgt caactacttc caccggcagc tgatgcacga cacccgggcg
    16441 gactggcgca ggctgctgcg cacccgccgc ccgcgcaggt cgcatctcgc ggaggacctg
    16501 cgcacacacc gcgatgaccg tgtacgaacc agcggccccc acggccgtgc ccggcggcgt
    16561 ccggcacggc agccgcgcga gaccgaggaa cggtgttcat gaccccaccg gaagcgaagg
    16621 gggcgtcggc cccggccggc ggcctgccca tcgagatcgc cgccctgtcg aagcggtacc
    16681 gcgacacctg ggcggtggag gacctgtcct tcacggtcgc gccgggacgc gtcaccggct
    16741 tcctcggccc gaacggggcc ggcaagacga cgacgctccg catgctcctc ggcctcaccg
    16801 ccccgacgtc cgggaccgcg accgtcggcg gacggcgcta ccgcgacctg gcgcagccgc
    16861 tcgcaaccgt cggggcgatg ctcgacgagt ccggcgcgca ccgcaggcgt acgggccgcg
    16921 accacctgcg cgtgcagtgc gcggcgacgg gacttccggc ccggcgggcc gacgaggtgc
    16981 tcgaccgcgt cggcctcctc cgggcgggga ggaaacgcta cgaggagtac tcgctgggca
    17041 tgcggcaacg gctcaacctg gcccaggcgc tgctcggcga tccgcccgtc ctggtcctcg
    17101 acgaaccggc caacggcctc gatccggagg gcatcgcctg gatgcgcgcc ctgctgcgga
    17161 acctggccgc cgagggccgc acggtgctcg tctccagcca cctcatctcc gaggtcgagc
    17221 agacggccga cgacctcgtg atcatcagcc ggggacggct ggtcgcggag gggtcgagcc
    17281 gcgagatcgc cgggcgggta cggggcgagg cccgggtgcg ggtgcgctcc tcccggcccg
    17341 cggagctggc ggcggcgctc gcggcggcgg gagcgacggt gtccccgccc gccggggacg
    17401 gcctcctgat cgtgggcggc ctcgggacgg ccgcggtggc cgccgtcgcc gccggacacg
    17461 gcggggaact gtacgaactg gccgaggaag cccccgatct ggagcaggcg ttcctgcggc
    17521 tgacgcaggg gaaggcggag atccggtgat gggactgatc ggcagcgaac tgctcaaggt
    17581 ccgtacgctg cgcacctggt ggatcgccgg gctctgcatg gccgtggcgg cggttctgcc
    17641 ggcgctgtgg aacagctggc aggcccacac cttcatgcag cccttcgagg attacctggc
    17701 gggcgcggtc ctgacccccc gcgaggacat gtcggccgag caggtcggtg cgatgcgcga
    17761 cctctgggag aggcagagcg ctcccgaccg catcgccgcc gctctctaca cctccgggca
    17821 gaccgccggg ctgctgctgg cgggcgtgct gggcgtcctg ctggtgacga acgagtacca
    17881 gtaccggacc ctgacggcca cattcctggc cgtgccccgc cggggccgcg tgatcgcggc
    17941 caagctcgtc gcggtgctgg tctgctgcgc cgggctgtgg ctggtggcga cggcgggcgg
    18001 gctcgtcgtc ggcggcgtct tcctcgcctc ccagggcgcc ggtcccgggc tgggcgacgg
    18061 cgacgtggcc ggcgcggtcc tgctgaacct ggccgcctac ctggtgtggg gcgtgttcgg
    18121 cttcgggctg ggggcgctca tccgcagcca gaccgccgcg accgtcaccg ccgccgtgct
    18181 gtacttcctg tcctcggtcg tcgtggcctt cgcgttccag gccgtccacg acctcgtcct
    18241 cgaagaggac tgggtgctcc aggcgcaggt gctgctgccc ggcgtcgcgt cccagatcat
    18301 gaccacgccc ggcgaactgt tctccggggc cccggccgcg tggacggggg ccgtggtgct
    18361 cgtcgcctac ggcctgctcg gcggcctcac cgggacgctg ctcctgcggc ggcgggacgt
    18421 gacctgagcc cggtgctccc tcggcggtcg gcgcggtccg gcggccccgc ggcccggaac
    18481 cgtgccgacg gaccgcccgg ccccgccgcc cggtccggct gccgcgcccg ccgccgcgcc
    18541 cgccgcccgt cccgcgccgc tcccgcaccg gcccgccgcg tcaggagggc agggtccgcg
    18601 ggggtcttcg gcactggcac cgctccgccg cgacctgcgc cctggacgcg acgagccgca
    18661 gcgcctcctc gcggtcccag ttgagcgccg cgctccgcat cgcctcgata ccgggcggca
    18721 gatcgagccc caggtcctcc gcgaacagcc gctggcagcg cttgaccacc gacagcgtgc
    18781 ccaccgcgtc gccgtgcagg cagtgcaccg ccgcgagcag ttcccacagg tgctgccggt
    18841 agggggcctc cgcgatgacg ctctcgatgc ggtaggccag catgctggtg cggccggcca
    18901 ggaccgaggc ggtgaagagg tcctgatagg cgtcgaaacg gatgttgttg agccccgcta
    18961 tgtgggcgtt gaaccaccgt gtgggcggga ggtcctgccc gaacggcccc ctccacaggc
    19021 ccacggcctg ctccagtgcg ccgaccgccg cctcgtggga gccggccaga agccagttcc
    19081 ggccacgttg gacggccgcg gtgaaatgcg gaaggtcgaa ctcctcggcc gcgatctcca
    19141 gtccgtatcc gcactggccg ccccggtagg tccgcacccg ctcaccgagc cccggctcga
    19201 cctcgtcgag gtccctgcgc agtcccgtga cgtggctgcg gaggttggcg gtggccgaca
    19261 ccgggggctc gtcccacagg atctcgctga actccgcgat gccgatgggc tggccgaagc
    19321 ggagcaggca cgcggtcagg acggcccgcc ggacgggcga ggtgacggac agggtggtgc
    19381 ctcggacgga cagctgcccg agcacgccga agaacggttc ggggaggacg tccgccgtgc
    19441 ggaccggcgc cgcctcggcg gccgggggcg cgctcgccgg tccgggccac gcggtgtggg
    19501 gggcggggcc ggagggaaga ccggcccgtg gggtgtggat caacaggagt ccccccgccg
    19561 gcacggcgtg aggggcgcgc cggtggtggg cggcgtcagc tccgcggccc gcttcccgtg
    19621 gtcgggcgag acagcgggaa gtgcggatcg tgtgatgacg tgcgaggtcc gcctgaagtg
    19681 cgtcatgtcg tctcctgctt ggtcagggca gggggaacgc acagctgtgt cccgcatccg
    19741 ttcccccgtt ggaactgcgc tcacgctgtc agagggaacg agatccggct agcaacaggg
    19801 tgtgattgac ctgaaccgga cggtcgggaa tcttccgatc cgttctactg ggaggtaggg
    19861 ttcgccgctt ccgttcgtga agacgcgccg acctgttcgg gcggcccgcc acaccgcccc
    19921 gtgtccgccc cgccctgccc tgccgcgccg ccctgccgcg cggcccggac gcccgcgcgc
    19981 tcgcagaaaa ccatgcaagc gcgcttgatt gtttaccggg ccgctgccat gctcctgggc
    20041 accacatccg gtcccgaggg gagcgcacgt gtccgatgcc gcagccgtga tcgatgatct
    20101 gcgcgaggag agcgccgaac tcgaagccat ggtcagggag ttggctccgg agcggtggaa
    20161 cgggccgacg cccgccgccg ggtggaccct cgcccaccag atcgcccacc tcacctggac
    20221 cgacgaggtc gcgctgctgg ccgccaccga gccggaccgg ttcggtgagg aggtcgccaa
    20281 ggcgctggcg gctcccgact cgttcgtcga cgaggccgcc ggggagctgg tcgcggccct
    20341 ctcgccggac gccctgctcg cccggtggcg cgccgggcgc gggcggctgg acgccgtgct
    20401 gcgcgaggct ccgcggggag cccgcatccc ctggtacggc ccgccgatga gcgtcgcctc
    20461 gatggccacc gcccggctca tggagacctg ggcgcacggc caggacgtcg ccgacgccct
    20521 cggcgtcgcc cgccgcccca cggcccggct gcggcacgtc gcccggatcg gcgtacgggc
    20581 gcgggactac gcgtacgcgg tgcgcgggat cgccgcgccc gaggaggagt tccgggtcga
    20641 gctgcacacc ccgcacggcg agacgatcgc gttcgggccg accggggccg cccagcgcgt
    20701 caccggcccg ctgctcgact tctgcctcct ggtcacccag cgcgcccacc gcctcgacct
    20761 cgccgtcacc gcggagggcc gcgaggcgga ccagtggctc ggcatcgccc aggcgttcgc
    20821 cgggccgccg ggaccgggcc gcctgccgcg cggcgaatgg cccgagcgcg ccgaccggcc
    20881 cgagccgggc gggcggtccg agccgggcgg gcggtccgag cacaccgagc gcggcgaacg
    20941 gcccggggcg tgagcggcgc gccgctgcgc gtcggcaacg cctccggctt ctacggcgac
    21001 cgcttcgacg ccttgcgcga gatgctgacc ggcggcccgc tcgacgtcct caccggcgac
    21061 tacctggccg aactgaccat gctcatcctc ggacgcaacc gcctgaaggg ccccggccgc
    21121 gggtacgccg ccaccttcct gcgccagctc gaagaggggc tggggctcgc ccacgagcgc
    21181 ggggtgaaga tcgtcgtcaa cgcgggcggc ctcgacccgg ccggactcgc cgacgccgta
    21241 agggcgttgg ccgagcgggt gggcgtgccg gcgcgggtcg gccatgtcga gggcgacagc
    21301 ctgccggtgc ccgacggctt cctcaccgcc aacgcctacc tcggcggcgg cgggatcgcc
    21361 gcctgcctgc gggccggggc cgatgtcgtc gtcaccggcc ggaccaccga cgcggccctg
    21421 gtcaccgggc ccgccgccgc ccgcttcggc tggggtcccg acgatctgga cgcgctcgcg
    21481 ggggccgtcg tcgccgggca cgtactggag tgcgggaccc aggcgaccgg cgggaactac
    21541 gccttcttcg gggagcacga cgtccgccgc cccggctttc cggtcgccga gatccacgcc
    21601 gacggctcgt gcgtcatcac caagcacgac ggcacgggcg gcgtggtcga cgtcgggacc
    21661 gtgaccgccc aactcctcta cgagaccgac ggagcccggt acgcgggccc cgatgcgacc
    21721 gcccgcctcg acaccgtacg gctgacccgg ctcggcccgg accgggtccg tgtcgacggg
    21781 gtgcgcggcg aggccccgcc gcccaccctc aaggccgggc tcacgcggct cggcggctgg
    21841 cgcaacgagg tcgtcttcgt cctcaccggc ctcgacgtcg aggccaaggc ccgcctggtg
    21901 cgggcccagt tcaccgacgc cctggagcgg agcggggcgc gagggcccgc cgaggtgcgc
    21961 tgggagctgg cccgtaccga ccacgccgac gccggcaccg aggaacgggc cgcggcgctg
    22021 ctccggctgg tcgtccgcga ccgggacgcc gacgcggtgg gccgggccgt ctcgggggcc
    22081 gccgtggaac tggccctcgg cagctacccc ggcttccacg tcaccgcccc gcccggaccg
    22141 ggcgcgccct acggcgtgtt cgaggcccgg tacgtgcccg cggcggacgt cgcgcacgtc
    22201 gcggtgcggc ccgacgggag ccgcgaggcc gtggaccacc ccgtccggac ccggccgctc
    22261 gcgcccgtgg acgagccgcc gctgcccgag ccgtaccccg ccgggcccac ccggcgcgcc
    22321 ccgctcgggc tgatcgcggg ggcccggagc ggcgacaagg gcggtgacgc caacgtcggc
    22381 gtatgggtgc gcgacgacga cgcgtggcgg tggctggccc acgagctgac cgtcgagcgg
    22441 ttccgcgaac tcctgccgga gaccgccgga ctgaccgtcg tccgccatgt cctgcccaac
    22501 ctccgcgccc tgaacttcac cgtgcgcggg ctgctcggcg agggcgtcgc cgcccgcgcc
    22561 cggttcgacc cgcaggccaa ggcggtgggg gagtggctgc gctcgcggtg gctgcccgtc
    22621 cccgtaccgc tgctggagcg agcccacgcc ccgtcgccgg aggtgaccgt atgaccgtcc
    22681 tgcccagcgc gctcgacacc gccggagccg agtacgcggc ccaccgcgcc gccatgctcg
    22741 gcaagctcgc cgcgctggag gccgaacacg cgcgggcgct cgcgggcggc ggcgagaagt
    22801 acaccgcccg ccaccgggcg cgcggcaagc tcccggcgcg cgagcgcgtc gagttgctgc
    22861 tcgaacccga caccccgttc ctggagctgt cgcccctggc cgcctggggc agcgactacg
    22921 cggtcggggc ctcgctcgtc accgggatcg gggtggtggc gggcgtggag tgcctgatca
    22981 cggccaacga cccgaccgtg cgcggcgggg cctcgaaccc gtggacgctg aagaagtcgc
    23041 tgcgggccaa cgagatcgcc ctcgccaacc ggctgccctg cgtcagcctg gtcgagtcgg
    23101 gcggggccga cctgccgtcc cagaaggaga tcttcattcc gggcggcgcg ctgttccgcg
    23161 acctcacccg gctctccgcc gccggaatcc ccaccgtcgc cgtcgtgttc ggcaactcca
    23221 ccgccggagg cgcgtacgtg cccggcatgt ccgaccacac cgtgatgatc aaggaccgct
    23281 ccaaggtctt cctcggcggg ccgccgctgg tgcgg
//
